Detailed information for compound 739613

Basic information

Technical information
  • TDR Targets ID: 739613
  • Name: 2-[ethyl-(4-methylphenyl)sulfonylamino]acetic acid
  • MW: 257.306 | Formula: C11H15NO4S
  • H donors: 1 H acceptors: 4 LogP: 1.4 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCN(S(=O)(=O)c1ccc(cc1)C)CC(=O)O
  • InChi: 1S/C11H15NO4S/c1-3-12(8-11(13)14)17(15,16)10-6-4-9(2)5-7-10/h4-7H,3,8H2,1-2H3,(H,13,14)
  • InChiKey: VLAUMFPAOAEZFL-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 2-[ethyl-(4-methylphenyl)sulfonyl-amino]acetic acid
  • 2-[ethyl-(4-methylphenyl)sulfonyl-amino]ethanoic acid
  • CBKinase1_008810
  • CBKinase1_021210

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni inositol monophosphatase 0.0039 0.0348 0.0864
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0013 0.0033 0.0013
Brugia malayi Inositol-1 0.0039 0.0348 0.0554
Loa Loa (eye worm) hypothetical protein 0.0333 0.3924 0.6865
Trypanosoma cruzi importin beta-1 subunit, putative 0.0024 0.0163 0.2043
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0074 0.0778 0.1226
Schistosoma mansoni alpha-glucosidase 0.0141 0.1589 0.3948
Mycobacterium tuberculosis Conserved protein 0.0074 0.0778 0.1226
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0045 0.0419 0.0996
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0017 0.0076 0.0923
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0039 0.0348 1
Trypanosoma cruzi PAB1-binding protein , putative 0.0027 0.0198 0.2497
Brugia malayi hypothetical protein 0.0017 0.0084 0.0089
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0139 0.1564 0.2732
Schistosoma mansoni blooms syndrome DNA helicase 0.0011 0.0005 0.0012
Mycobacterium ulcerans hypothetical protein 0.0074 0.0778 0.2167
Loa Loa (eye worm) hypothetical protein 0.0062 0.0624 0.1084
Loa Loa (eye worm) hypothetical protein 0.0074 0.0778 0.1354
Echinococcus multilocularis inositol monophosphatase 1 0.0039 0.0348 0.0328
Echinococcus granulosus snurportin 1 0.0311 0.3654 0.9071
Loa Loa (eye worm) ATP-dependent DNA helicase 0.0021 0.0129 0.0218
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative 0.0021 0.0129 0.1203
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0429 0.509 0.8908
Trichomonas vaginalis ap endonuclease, putative 0.0018 0.0099 0.0101
Trichomonas vaginalis D-aminoacylase, putative 0.0074 0.0778 0.1278
Toxoplasma gondii HEAT repeat-containing protein 0.0029 0.023 0.0586
Echinococcus granulosus ATP dependent DNA helicase Q1 0.0021 0.0129 0.0272
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0017 0.0076 0.014
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0164 0.1867 0.3262
Loa Loa (eye worm) hypothetical protein 0.0017 0.0076 0.0125
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0039 0.0348 0.0533
Onchocerca volvulus 0.0062 0.0624 0.1011
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0074 0.0778 0.1311
Mycobacterium tuberculosis Probable hydrolase 0.0074 0.0778 0.1226
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0018 0.0099 0.1216
Loa Loa (eye worm) hypothetical protein 0.0074 0.0778 0.1354
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0018 0.0099 0.2843
Loa Loa (eye worm) beta-lactamase 0.0074 0.0778 0.1354
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0024 0.0163 0.0212
Echinococcus granulosus histone lysine methyltransferase setb 0.0062 0.0624 0.1506
Schistosoma mansoni survival motor neuron protein 0.005 0.0478 0.1187
Trypanosoma brucei glucosidase, putative 0.0036 0.0318 0.3759
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0039 0.0348 1
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0074 0.0778 0.1354
Loa Loa (eye worm) hypothetical protein 0.0074 0.0778 0.1354
Trichomonas vaginalis DNA helicase recq, putative 0.0021 0.0129 0.0154
Brugia malayi hypothetical protein 0.0243 0.2828 0.4921
Trypanosoma cruzi hypothetical protein, conserved 0.0074 0.0778 1
Schistosoma mansoni inositol monophosphatase 0.0039 0.0348 0.0864
Echinococcus multilocularis ATP dependent DNA helicase Q5 0.0021 0.0129 0.0109
Brugia malayi jmjC domain containing protein 0.0017 0.0076 0.0076
Trichomonas vaginalis ap endonuclease, putative 0.0018 0.0099 0.0101
Trypanosoma brucei importin beta-1 subunit, putative 0.0029 0.023 0.2568
Trypanosoma cruzi hypothetical protein, conserved 0.0074 0.0778 1
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0039 0.0348 0.4436
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0021 0.0129 0.1606
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.0045 0.0419 0.0679
Leishmania major hypothetical protein, conserved 0.0074 0.0778 1
Schistosoma mansoni phd/f-box containing protein 0.0017 0.0076 0.0189
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0074 0.0778 0.1226
Brugia malayi beta-lactamase 0.0074 0.0778 0.1311
Schistosoma mansoni hypothetical protein 0.0342 0.4026 1
Echinococcus multilocularis phd:f box containing protein 0.0017 0.0076 0.0056
Trichomonas vaginalis set domain proteins, putative 0.0489 0.581 1
Toxoplasma gondii histone lysine demethylase JMJD6a 0.0017 0.0076 0.0194
Brugia malayi follicle stimulating hormone receptor 0.0481 0.5713 1
Mycobacterium tuberculosis Probable lipase LipE 0.0074 0.0778 0.1226
Echinococcus multilocularis ATP dependent DNA helicase Q1 0.0021 0.0129 0.0109
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0017 0.0076 0.0923
Loa Loa (eye worm) hypothetical protein 0.0039 0.0347 0.06
Echinococcus multilocularis jumonji domain containing 1A 0.0017 0.0076 0.0056
Leishmania major hypothetical protein, conserved 0.0017 0.0076 0.0486
Echinococcus multilocularis geminin 0.0342 0.4026 0.4014
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0062 0.0624 0.0605
Toxoplasma gondii hypothetical protein 0.0333 0.3924 1
Leishmania major alpha glucosidase II subunit, putative 0.0036 0.0318 0.3759
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0139 0.1564 0.3854
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0475 0.5638 1
Schistosoma mansoni alpha-glucosidase 0.0141 0.1589 0.3948
Loa Loa (eye worm) hypothetical protein 0.0074 0.0778 0.1354
Brugia malayi exodeoxyribonuclease III family protein 0.0018 0.0099 0.0116
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0318 0.4046
Brugia malayi Glycosyl hydrolases family 31 protein 0.0164 0.1867 0.3228
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0481 0.5713 1
Echinococcus multilocularis lysosomal alpha glucosidase 0.0164 0.1867 0.185
Brugia malayi glutaminase DH11.1 0.0276 0.3231 0.563
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0139 0.1564 0.1547
Brugia malayi Glycosyl hydrolases family 31 protein 0.0036 0.0318 0.0501
Brugia malayi beta-lactamase family protein 0.0074 0.0778 0.1311
Brugia malayi jmjC domain containing protein 0.0017 0.0076 0.0076
Onchocerca volvulus 0.0074 0.0778 0.1278
Loa Loa (eye worm) hypothetical protein 0.0017 0.0076 0.0125
Echinococcus granulosus survival motor neuron protein 1 0.0243 0.2828 0.7009
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0018 0.0099 0.1271
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0036 0.0318 0.9133
Brugia malayi jmjC domain containing protein 0.0017 0.0076 0.0076
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0024 0.0163 0.0212
Echinococcus granulosus jumonji domain containing 1A 0.0017 0.0076 0.014
Loa Loa (eye worm) hypothetical protein 0.0021 0.0129 0.0218
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0018 0.0099 0.0165
Brugia malayi jmjC domain containing protein 0.0017 0.0076 0.0076
Echinococcus multilocularis voltage gated potassium channel 0.0013 0.0033 0.0013
Schistosoma mansoni ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related 0.0017 0.0076 0.0189
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0062 0.0624 0.1589
Plasmodium falciparum importin beta, putative 0.0029 0.023 1
Schistosoma mansoni voltage-gated potassium channel 0.0049 0.0469 0.1165
Entamoeba histolytica recQ family DNA helicase 0.0011 0.0005 0.0141
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0021 0.0129 0.0329
Schistosoma mansoni hypothetical protein 0.0012 0.002 0.005
Treponema pallidum exodeoxyribonuclease (exoA) 0.0018 0.0099 1
Brugia malayi Pre-SET motif family protein 0.0429 0.509 0.8902
Echinococcus multilocularis lysine specific demethylase 6a 0.0017 0.0076 0.0056
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0039 0.0348 0.4168
Onchocerca volvulus 0.005 0.0478 0.0759
Trichomonas vaginalis penicillin-binding protein, putative 0.0074 0.0778 0.1278
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0074 0.0778 0.1932
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0074 0.0778 0.1226
Trichomonas vaginalis D-aminoacylase, putative 0.0074 0.0778 0.1278
Echinococcus granulosus neutral alpha glucosidase AB 0.0036 0.0318 0.0742
Echinococcus granulosus phd:f box containing protein 0.0017 0.0076 0.014
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0139 0.1564 0.3885
Trichomonas vaginalis sucrase-isomaltase, putative 0.0036 0.0318 0.0481
Echinococcus granulosus bloom syndrome protein 0.0021 0.0129 0.0272
Echinococcus multilocularis snurportin 1 0.0311 0.3654 0.3641
Echinococcus granulosus beta LACTamase domain containing family member 0.0074 0.0778 0.1891
Loa Loa (eye worm) hypothetical protein 0.0014 0.004 0.0062
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0139 0.1564 0.3885
Mycobacterium leprae Probable lipase LipE 0.0074 0.0778 1
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0039 0.0348 0.4168
Mycobacterium ulcerans glutaminase 0.0276 0.3231 1
Brugia malayi Bloom's syndrome protein homolog 0.0021 0.0129 0.0169
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0139 0.1564 0.1547
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0018 0.0099 0.0079
Trypanosoma brucei importin beta-1 subunit, putative 0.0029 0.023 0.2568
Echinococcus multilocularis survival motor neuron protein 1 0.0243 0.2828 0.2814
Loa Loa (eye worm) jmjC domain-containing protein 0.0062 0.0627 0.109
Loa Loa (eye worm) hypothetical protein 0.0027 0.0198 0.0338
Schistosoma mansoni ap endonuclease 0.0018 0.0099 0.0246
Schistosoma mansoni protein phosphatase 2C 0.0017 0.0076 0.0189
Schistosoma mansoni jumonji domain containing protein 0.0062 0.0627 0.1558
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0013 0.0033 0.0032
Echinococcus multilocularis lysosomal alpha glucosidase 0.0164 0.1867 0.185
Toxoplasma gondii histone lysine demethylase JMJC1/KDM5D/JARID1D 0.0017 0.0076 0.0194
Toxoplasma gondii ABC1 family protein 0.0074 0.0778 0.1982
Trypanosoma brucei JmjC domain, hydroxylase, putative 0.0017 0.0076 0.0486
Echinococcus granulosus importin subunit beta 1 0.0029 0.023 0.0523
Mycobacterium tuberculosis Probable lipase LipD 0.0074 0.0778 0.1226
Brugia malayi Pre-SET motif family protein 0.0062 0.0624 0.1039
Mycobacterium leprae conserved hypothetical protein 0.0074 0.0778 1
Echinococcus granulosus lysine specific demethylase 5A 0.0062 0.0627 0.1515
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0035 0.0298 0.036
Loa Loa (eye worm) hypothetical protein 0.0243 0.2828 0.4946
Schistosoma mansoni DNA helicase recq1 0.0021 0.0129 0.0321
Echinococcus multilocularis importin subunit beta 1 0.0029 0.023 0.021
Trichomonas vaginalis alpha-glucosidase, putative 0.0036 0.0318 0.0481
Plasmodium vivax JmjC domain containing protein 0.0017 0.0076 0.098
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0039 0.0348 0.0533
Trichomonas vaginalis DNA helicase recq1, putative 0.0021 0.0129 0.0154
Schistosoma mansoni phosphatidylserine receptor 0.0017 0.0076 0.0189
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0074 0.0778 0.2167
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0062 0.0624 0.0605
Mycobacterium ulcerans esterase/lipase LipP 0.0074 0.0778 0.2167
Plasmodium falciparum ataxin-2 like protein, putative 0.0027 0.0198 0.7924
Echinococcus granulosus inositol monophosphatase 1 0.0039 0.0348 0.0817
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0036 0.0318 0.0481
Schistosoma mansoni ap endonuclease 0.0018 0.0099 0.0246
Schistosoma mansoni jumonji/arid domain-containing protein 0.0062 0.0627 0.1558
Echinococcus multilocularis lysine specific demethylase 5A 0.0062 0.0627 0.0608
Echinococcus granulosus lysine specific demethylase 6a 0.0017 0.0076 0.014
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0039 0.0348 0.4436
Trichomonas vaginalis alpha-glucosidase, putative 0.0036 0.0318 0.0481
Brugia malayi beta-lactamase family protein 0.0074 0.0778 0.1311
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0021 0.0129 0.0329
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0021 0.0129 0.0169
Brugia malayi RNA, U transporter 1 0.0083 0.0882 0.1495
Entamoeba histolytica hypothetical protein 0.0024 0.0163 0.4682
Plasmodium falciparum ATP-dependent DNA helicase Q1 0.0021 0.0129 0.3441
Brugia malayi jmjC domain containing protein 0.0062 0.0627 0.1046
Brugia malayi Glycosyl hydrolases family 31 protein 0.0014 0.004 0.0013
Brugia malayi hypothetical protein 0.0027 0.0198 0.029
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0045 0.0419 0.04
Loa Loa (eye worm) hypothetical protein 0.0333 0.3924 0.6865
Schistosoma mansoni importin beta-1 0.0029 0.023 0.0571
Schistosoma mansoni alpha glucosidase 0.0036 0.0318 0.0789
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0139 0.1564 0.2695
Brugia malayi jmjC domain containing protein 0.0062 0.0627 0.1046
Trypanosoma cruzi PAB1-binding protein , putative 0.0027 0.0198 0.2497
Schistosoma mansoni hypothetical protein 0.0342 0.4026 1
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0042 0.0383 0.0595
Loa Loa (eye worm) hypothetical protein 0.0017 0.0076 0.0125
Schistosoma mansoni jumonji domain containing protein 0.0017 0.0076 0.0189
Trichomonas vaginalis alpha-glucosidase, putative 0.0036 0.0318 0.0481
Schistosoma mansoni voltage-gated potassium channel 0.0049 0.0469 0.1165
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0139 0.1564 0.3854
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0062 0.0627 0.1515
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0039 0.0348 0.0795
Trichomonas vaginalis maltase-glucoamylase, putative 0.0036 0.0318 0.0481
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0062 0.0627 0.0608
Leishmania major hypothetical protein, conserved 0.0027 0.0198 0.2136
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0017 0.0076 0.0056
Plasmodium vivax ataxin-2 like protein, putative 0.0027 0.0198 0.2544
Loa Loa (eye worm) hypothetical protein 0.0029 0.023 0.0394
Entamoeba histolytica recQ family helicase, putative 0.0021 0.0129 0.3711
Mycobacterium tuberculosis Probable esterase LipL 0.0074 0.0778 0.1226
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative 0.0011 0.0005 0.0063
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0062 0.0624 0.1549
Echinococcus granulosus lysosomal alpha glucosidase 0.0164 0.1867 0.4609
Onchocerca volvulus 0.0074 0.0778 0.1278
Loa Loa (eye worm) inward rectifying k channel family protein 1 0.0333 0.3924 0.6865
Trichomonas vaginalis glutaminase, putative 0.0276 0.3231 0.5531
Schistosoma mansoni jumonji/arid domain-containing protein 0.0062 0.0627 0.1558
Plasmodium vivax importin-beta 2, putative 0.0029 0.023 0.2954
Leishmania major importin beta-1 subunit, putative 0.0024 0.0163 0.1661
Loa Loa (eye worm) hypothetical protein 0.0333 0.3924 0.6865
Onchocerca volvulus 0.0074 0.0778 0.1278
Echinococcus granulosus JmjC domain containing protein 4 0.0017 0.0076 0.014
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0011 0.0005 0.0013
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0036 0.0318 0.9133
Echinococcus multilocularis bloom syndrome protein 0.0021 0.0129 0.0109
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0036 0.0318 0.0481
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0062 0.0624 0.1549
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0059 0.0596 0.1437
Schistosoma mansoni DNA helicase recq5 0.0021 0.0129 0.0321
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0014 0.004 0.1161
Trypanosoma cruzi glycosyl hydrolase-like protein, putative 0.0014 0.004 0.0459
Loa Loa (eye worm) hypothetical protein 0.0011 0.0005 0.00000000018292
Trypanosoma brucei PAB1-binding protein , putative 0.0027 0.0198 0.2136
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0062 0.0624 0.1549
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0074 0.0778 0.1932
Plasmodium vivax hypothetical protein, conserved 0.0074 0.0778 1
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0036 0.0318 0.0809
Loa Loa (eye worm) hypothetical protein 0.0074 0.0778 0.1354
Mycobacterium tuberculosis Conserved protein 0.0074 0.0778 0.1226
Loa Loa (eye worm) jmjC domain-containing protein 0.0017 0.0076 0.0125
Loa Loa (eye worm) jmjC domain-containing protein 0.0017 0.0076 0.0125
Schistosoma mansoni hypothetical protein 0.0311 0.3654 0.9076
Trichomonas vaginalis esterase, putative 0.0074 0.0778 0.1278
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0039 0.0348 0.0886
Loa Loa (eye worm) inositol-1 0.0039 0.0348 0.0601
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.0021 0.0129 0.1203
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0018 0.0099 0.1474
Echinococcus granulosus geminin 0.0342 0.4026 1
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0311 0.3654 0.6393
Echinococcus granulosus ATP dependent DNA helicase Q5 0.0021 0.0129 0.0272
Trichomonas vaginalis penicillin-binding protein, putative 0.0074 0.0778 0.1278
Trichomonas vaginalis alpha-glucosidase, putative 0.0036 0.0318 0.0481
Trichomonas vaginalis alpha-glucosidase, putative 0.0036 0.0318 0.0481
Schistosoma mansoni glutaminase 0.0276 0.3231 0.8025
Plasmodium falciparum ataxin-2 like protein, putative 0.0027 0.0198 0.7924
Loa Loa (eye worm) hypothetical protein 0.0074 0.0778 0.1354
Trypanosoma cruzi glycosyl hydrolase-like protein, putative 0.0014 0.004 0.0459
Trichomonas vaginalis DNA helicase recq, putative 0.0021 0.0129 0.0154
Loa Loa (eye worm) RecQ helicase 0.0021 0.0129 0.0218
Toxoplasma gondii LsmAD domain-containing protein 0.0027 0.0198 0.0504
Trichomonas vaginalis inositol monophosphatase, putative 0.0039 0.0348 0.0533
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.0045 0.0419 0.0726
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0036 0.0318 0.0548
Loa Loa (eye worm) hypothetical protein 0.0013 0.0033 0.005
Brugia malayi Importin beta-1 subunit 0.0029 0.023 0.0346
Schistosoma mansoni voltage-gated potassium channel 0.0013 0.0033 0.0083
Trichomonas vaginalis D-aminoacylase, putative 0.0074 0.0778 0.1278
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0021 0.0129 0.0169
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0018 0.0099 0.1216
Echinococcus granulosus voltage gated potassium channel 0.0013 0.0033 0.0032
Onchocerca volvulus 0.0095 0.1027 0.1711
Echinococcus multilocularis beta LACTamase domain containing family member 0.0074 0.0778 0.0759
Loa Loa (eye worm) glutaminase 2 0.0276 0.3231 0.5652
Loa Loa (eye worm) jmjC domain-containing protein 0.0017 0.0076 0.0125
Echinococcus multilocularis neutral alpha glucosidase AB 0.0036 0.0318 0.0298
Onchocerca volvulus 0.0489 0.581 1
Giardia lamblia Sgs1 DNA helicase, putative 0.0021 0.0129 1
Echinococcus multilocularis JmjC domain containing protein 4 0.0017 0.0076 0.0056
Loa Loa (eye worm) glutaminase 0.0276 0.3231 0.5652
Plasmodium vivax SET domain protein, putative 0.0062 0.0624 0.8018
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0018 0.0099 0.0196
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0062 0.0624 0.1549
Mycobacterium tuberculosis Conserved protein 0.0074 0.0778 0.1226
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0139 0.1564 0.3885
Mycobacterium ulcerans lipase LipD 0.0074 0.0778 0.2167
Trichomonas vaginalis importin beta-1, putative 0.0024 0.0163 0.0212
Toxoplasma gondii exonuclease III APE 0.0018 0.0099 0.0252
Mycobacterium ulcerans beta-lactamase 0.0074 0.0778 0.2167
Trypanosoma brucei hypothetical protein, conserved 0.0074 0.0778 1
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0018 0.0099 0.0793
Schistosoma mansoni hypothetical protein 0.005 0.0478 0.1187
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0318 0.4046
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0018 0.0099 0.0793
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0021 0.0129 0.3441
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0042 0.0383 0.0595
Schistosoma mansoni voltage-gated potassium channel 0.0013 0.0033 0.0083
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.005 0.0478 0.0783

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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