TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 316.287 | Formula: C11H12N2O7S
H donors: 4 H acceptors: 7 LogP: -1.11 Rotable bonds: 7
Rule of 5 violations (Lipinski): 1
SMILES: OC(=O)C[C@@H](C(=O)O)NC(=O)c1ccc(cc1)S(=O)(=O)N
InChi: 1S/C11H12N2O7S/c12-21(19,20)7-3-1-6(2-4-7)10(16)13-8(11(17)18)5-9(14)15/h1-4,8H,5H2,(H,13,16)(H,14,15)(H,17,18)(H2,12,19,20)/t8-/m0/s1
InChiKey: QQBJZBQHKVLMGW-QMMMGPOBSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	carbonic anhydrase II	Starlite/ChEMBL	References
Homo sapiens	carbonic anhydrase I	Starlite/ChEMBL	References
Bos taurus	Carbonic anhydrase IV	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Schistosoma mansoni	carbonic anhydrase II (carbonate dehydratase II)	Get druggable targets OG5_127628	All targets in OG5_127628
Leishmania mexicana	carbonic anhydrase-like protein	Get druggable targets OG5_127628	All targets in OG5_127628
Leishmania donovani	carbonic anhydrase-like protein	Get druggable targets OG5_127628	All targets in OG5_127628
Trypanosoma congolense	carbonic anhydrase-like protein	Get druggable targets OG5_127628	All targets in OG5_127628
Trypanosoma brucei	carbonic anhydrase-like protein	Get druggable targets OG5_127628	All targets in OG5_127628
Leishmania braziliensis	carbonic anhydrase-like protein	Get druggable targets OG5_127628	All targets in OG5_127628
Echinococcus multilocularis	carbonic anhydrase II	Get druggable targets OG5_127628	All targets in OG5_127628
Trypanosoma cruzi	carbonic anhydrase-like protein, putative	Get druggable targets OG5_127628	All targets in OG5_127628
Leishmania major	carbonic anhydrase-like protein	Get druggable targets OG5_127628	All targets in OG5_127628
Loa Loa (eye worm)	carbonic anhydrase 3	Get druggable targets OG5_127628	All targets in OG5_127628
Echinococcus granulosus	carbonic anhydrase II	Get druggable targets OG5_127628	All targets in OG5_127628
Schistosoma mansoni	carbonic anhydrase II (carbonate dehydratase II)	Get druggable targets OG5_127628	All targets in OG5_127628
Schistosoma japonicum	ko:K01672 carbonic anhydrase [EC4.2.1.1], putative	Get druggable targets OG5_127628	All targets in OG5_127628
Brugia malayi	Putative carbonic anhydrase 5 precursor	Get druggable targets OG5_127628	All targets in OG5_127628
Brugia malayi	Eukaryotic-type carbonic anhydrase family protein	Get druggable targets OG5_127628	All targets in OG5_127628
Trypanosoma cruzi	carbonic anhydrase-like protein, putative	Get druggable targets OG5_127628	All targets in OG5_127628
Loa Loa (eye worm)	eukaryotic-type carbonic anhydrase	Get druggable targets OG5_127628	All targets in OG5_127628
Leishmania infantum	carbonic anhydrase-like protein	Get druggable targets OG5_127628	All targets in OG5_127628
Trypanosoma congolense	carbonic anhydrase-like protein	Get druggable targets OG5_127628	All targets in OG5_127628
Trypanosoma brucei gambiense	carbonic anhydrase-like protein	Get druggable targets OG5_127628	All targets in OG5_127628

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Schistosoma japonicum	ko:K01672 carbonic anhydrase [EC4.2.1.1], putative	Carbonic anhydrase IV	312 aa	253 aa	26.9 %
Trypanosoma brucei	carbonic anhydrase-like protein	carbonic anhydrase I	261 aa	281 aa	25.3 %
Leishmania mexicana	carbonic anhydrase-like protein	Carbonic anhydrase IV	312 aa	287 aa	26.8 %
Leishmania infantum	carbonic anhydrase-like protein	Carbonic anhydrase IV	312 aa	277 aa	26.7 %
Loa Loa (eye worm)	hypothetical protein	Carbonic anhydrase IV	312 aa	268 aa	25.4 %
Brugia malayi	Carbonic anhydrase like protein 2 precursor	carbonic anhydrase II	260 aa	259 aa	32.0 %
Onchocerca volvulus		Carbonic anhydrase IV	312 aa	252 aa	23.4 %
Echinococcus multilocularis	carbonic anhydrase	Carbonic anhydrase IV	312 aa	259 aa	30.1 %
Trypanosoma cruzi	carbonic anhydrase-like protein, putative	Carbonic anhydrase IV	312 aa	264 aa	25.4 %
Brugia malayi	Carbonic anhydrase like protein 2 precursor	Carbonic anhydrase IV	312 aa	268 aa	24.6 %
Schistosoma mansoni	carbonic anhydrase-related	Carbonic anhydrase IV	312 aa	264 aa	24.2 %
Echinococcus granulosus	carbonic anhydrase	Carbonic anhydrase IV	312 aa	304 aa	29.6 %
Schistosoma mansoni	carbonic anhydrase-related	Carbonic anhydrase IV	312 aa	265 aa	26.0 %
Leishmania braziliensis	carbonic anhydrase-like protein	Carbonic anhydrase IV	312 aa	277 aa	25.6 %
Schistosoma japonicum	ko:K01672 carbonic anhydrase [EC4.2.1.1], putative	Carbonic anhydrase IV	312 aa	322 aa	28.3 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Trichomonas vaginalis	CMGC family protein kinase	0.099	0.4244	1
Wolbachia endosymbiont of Brugia malayi	ribonuclease HI	0.0613	0.2587	1
Echinococcus granulosus	RNA directed DNA polymerase reverse transcriptase	0.0052	0.0121	0.0243
Echinococcus multilocularis	mitogen activated protein kinase	0.099	0.4244	1
Brugia malayi	hypothetical protein	0.0035	0.0046	0.0109
Plasmodium vivax	glutathione reductase, putative	0.0083	0.0257	1
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.0029	0.0018	0.0043
Leishmania major	2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein	0.0029	0.0018	0.0043
Trypanosoma brucei	carbonic anhydrase-like protein	0.0214	0.0834	0.0834
Mycobacterium tuberculosis	Probable oxidoreductase	0.021	0.0817	1
Trichomonas vaginalis	reverse transcriptases, putative	0.0052	0.0121	0.0243
Trypanosoma cruzi	mitogen activated protein kinase 2, putative	0.099	0.4244	1
Trichomonas vaginalis	NeSL-1_NeSL reverse transcriptases, putative	0.0052	0.0121	0.0243
Plasmodium falciparum	carbonic anhydrase	0.0101	0.0334	1
Trypanosoma brucei	dihydrolipoyl dehydrogenase	0.0029	0.0018	0.0018
Schistosoma mansoni	protein kinase	0.0052	0.0121	0.0103
Brugia malayi	Pao retrotransposon peptidase family protein	0.0052	0.0121	0.0285
Brugia malayi	Zinc knuckle family protein	0.0052	0.0121	0.0285
Giardia lamblia	Reverse transcriptase/endonuclease	0.0052	0.0121	0.0243
Trichomonas vaginalis	reverse transcriptases, putative	0.0052	0.0121	0.0243
Trypanosoma brucei	ingi protein (ORF1)	0.0666	0.2816	0.2816
Trypanosoma brucei	trypanothione reductase	0.0083	0.0257	0.0257
Toxoplasma gondii	hypothetical protein	0.0101	0.0334	0.0788
Brugia malayi	dihydrolipoyl dehydrogenase, mitochondrial precursor, putative	0.0029	0.0018	0.0043
Schistosoma mansoni	phosphoglucomutase	0.0613	0.2587	0.2574
Loa Loa (eye worm)	eukaryotic-type carbonic anhydrase	0.0214	0.0834	0.1964
Echinococcus multilocularis	carbonic anhydrase	0.0101	0.0334	0.0748
Trypanosoma brucei	hypothetical protein, conserved	0.0666	0.2816	0.2816
Echinococcus multilocularis	RNA directed DNA polymerase (reverse transcriptase)	0.0052	0.0121	0.0243
Echinococcus granulosus	carbonic anhydrase	0.0101	0.0334	0.0748
Schistosoma mansoni	hypothetical protein	0.0165	0.0618	0.0601
Trypanosoma brucei	RNA helicase, putative	0.2301	1	1
Chlamydia trachomatis	dihydrolipoyl dehydrogenase	0.0029	0.0018	0.5
Loa Loa (eye worm)	hypothetical protein	0.0101	0.0334	0.0788
Echinococcus multilocularis	telomerase reverse transcriptase subunit	0.0052	0.0121	0.0243
Echinococcus granulosus	carbonic anhydrase II	0.0214	0.0834	0.1929
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.0029	0.0018	0.0043
Brugia malayi	Pao retrotransposon peptidase family protein	0.0052	0.0121	0.0285
Brugia malayi	Eukaryotic-type carbonic anhydrase family protein	0.0214	0.0834	0.1964
Plasmodium falciparum	dihydrolipoyl dehydrogenase, mitochondrial	0.0029	0.0018	0.055
Mycobacterium tuberculosis	Probable reductase	0.0189	0.0724	0.8837
Schistosoma mansoni	phosphoglucomutase	0.0613	0.2587	0.2574
Loa Loa (eye worm)	carbonic anhydrase 3	0.0214	0.0834	0.1964
Trichomonas vaginalis	CMGC family protein kinase	0.099	0.4244	1
Plasmodium falciparum	glutathione reductase	0.0029	0.0018	0.055
Brugia malayi	Pao retrotransposon peptidase family protein	0.0052	0.0121	0.0285
Leishmania major	trypanothione reductase	0.0083	0.0257	0.0605
Brugia malayi	Pao retrotransposon peptidase family protein	0.0052	0.0121	0.0285
Mycobacterium ulcerans	flavoprotein disulfide reductase	0.0029	0.0018	0.5
Trypanosoma cruzi	mitogen-activated protein kinase 11, putative	0.099	0.4244	1
Trypanosoma cruzi	dihydrolipoyl dehydrogenase, putative	0.0029	0.0018	0.0043
Echinococcus multilocularis	RNA directed DNA polymerase (reverse transcriptase)	0.0052	0.0121	0.0243
Echinococcus multilocularis	RNA directed DNA polymerase (reverse transcriptase)	0.0052	0.0121	0.0243
Loa Loa (eye worm)	hypothetical protein	0.0101	0.0334	0.0788
Trypanosoma brucei	SLACS reverse transcriptase, putative	0.0052	0.0121	0.0121
Schistosoma mansoni	hypothetical protein	0.0165	0.0618	0.0601
Echinococcus granulosus	KRAB A domain containing protein	0.0052	0.0121	0.0243
Trypanosoma cruzi	trypanothione reductase, putative	0.0083	0.0257	0.0605
Echinococcus granulosus	mitogen activated protein kinase	0.099	0.4244	1
Mycobacterium tuberculosis	Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB	0.0189	0.0724	0.8837
Trypanosoma cruzi	mitogen-activated protein kinase 11, putative	0.099	0.4244	1
Brugia malayi	glutathione reductase	0.0083	0.0257	0.0605
Brugia malayi	Pao retrotransposon peptidase family protein	0.0052	0.0121	0.0285
Echinococcus multilocularis	carbonic anhydrase II	0.0214	0.0834	0.1929
Schistosoma mansoni	scy1(yeast) protein kinase-like	0.0052	0.0121	0.0103
Trypanosoma brucei	protein kinase, putative	0.099	0.4244	0.4244
Schistosoma mansoni	carbonic anhydrase-related	0.0101	0.0334	0.0317
Echinococcus multilocularis	carbonic anhydrase	0.0101	0.0334	0.0748
Echinococcus granulosus	geminin	0.0165	0.0618	0.1419
Brugia malayi	MAP kinase sur-1	0.099	0.4244	1
Echinococcus granulosus	ribonuclease H1	0.0613	0.2587	0.608
Onchocerca volvulus	Ribonuclease H1 homolog	0.0613	0.2587	1
Echinococcus granulosus	carbonic anhydrase	0.0101	0.0334	0.0748
Brugia malayi	Pao retrotransposon peptidase family protein	0.0052	0.0121	0.0285
Leishmania major	dihydrolipoamide dehydrogenase, putative	0.0029	0.0018	0.0043
Echinococcus granulosus	carbonic anhydrase	0.0101	0.0334	0.0748
Plasmodium vivax	dihydrolipoyl dehydrogenase, apicoplast, putative	0.0029	0.0018	0.0716
Brugia malayi	hypothetical protein	0.0052	0.0121	0.0285
Echinococcus granulosus	RNA directed DNA polymerase reverse transcriptase	0.0052	0.0121	0.0243
Entamoeba histolytica	hypothetical protein	0.0035	0.0046	0.5
Plasmodium falciparum	glutathione reductase	0.0083	0.0257	0.7679
Brugia malayi	Pao retrotransposon peptidase family protein	0.0052	0.0121	0.0285
Schistosoma mansoni	serine/threonine protein kinase	0.0061	0.016	0.0142
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.0029	0.0018	0.0043
Toxoplasma gondii	NADPH-glutathione reductase	0.0029	0.0018	0.0043
Brugia malayi	reverse transcriptase	0.0052	0.0121	0.0285
Schistosoma mansoni	phosphoglucomutase	0.0613	0.2587	0.2574
Entamoeba histolytica	hypothetical protein	0.0035	0.0046	0.5
Leishmania major	mitogen activated protein kinase, putative,map kinase, putative	0.099	0.4244	1
Brugia malayi	hypothetical protein	0.0052	0.0121	0.0285
Loa Loa (eye worm)	eukaryotic-type carbonic anhydrase	0.0101	0.0334	0.0788
Entamoeba histolytica	hypothetical protein	0.0035	0.0046	0.5
Brugia malayi	Pao retrotransposon peptidase family protein	0.0052	0.0121	0.0285
Echinococcus granulosus	mitogen activated protein kinase 3	0.099	0.4244	1
Trypanosoma cruzi	carbonic anhydrase-like protein, putative	0.0214	0.0834	0.1964
Schistosoma mansoni	carbonic anhydrase	0.0101	0.0334	0.0317
Toxoplasma gondii	ribonuclease HI protein	0.0613	0.2587	0.6097
Mycobacterium ulcerans	dihydrolipoamide dehydrogenase	0.0029	0.0018	0.5
Giardia lamblia	Kinase, CMGC MAPK	0.099	0.4244	1
Echinococcus granulosus	RNA directed DNA polymerase reverse transcriptase	0.0052	0.0121	0.0243
Toxoplasma gondii	thioredoxin reductase	0.0083	0.0257	0.0605
Echinococcus multilocularis	ribonuclease H1	0.0613	0.2587	0.608
Trypanosoma brucei	ribonuclease H1	0.0613	0.2587	0.2587
Brugia malayi	RNase H family protein	0.0613	0.2587	0.6097
Schistosoma mansoni	carbonic anhydrase II (carbonate dehydratase II)	0.0214	0.0834	0.0817
Plasmodium falciparum	thioredoxin reductase	0.0083	0.0257	0.7679
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.0029	0.0018	0.0043
Brugia malayi	Pao retrotransposon peptidase family protein	0.0052	0.0121	0.0285
Toxoplasma gondii	pyruvate dehydrogenase complex subunit PDH-E3II	0.0029	0.0018	0.0043
Echinococcus multilocularis	RNA directed DNA polymerase (reverse transcriptase)	0.0052	0.0121	0.0243
Echinococcus multilocularis	RNA directed DNA polymerase (reverse transcriptase)	0.0052	0.0121	0.0243
Brugia malayi	hypothetical protein	0.0052	0.0121	0.0285
Brugia malayi	Carbonic anhydrase like protein 2 precursor	0.0101	0.0334	0.0788
Trypanosoma cruzi	ribonuclease H1, putative	0.0613	0.2587	0.6097
Echinococcus multilocularis	thioredoxin glutathione reductase	0.0084	0.0259	0.0569
Trypanosoma brucei	dihydrolipoamide dehydrogenase	0.0029	0.0018	0.0018
Mycobacterium tuberculosis	Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras	0.021	0.0817	1
Trichomonas vaginalis	CMGC family protein kinase	0.099	0.4244	1
Echinococcus granulosus	RNA directed DNA polymerase	0.0052	0.0121	0.0243
Brugia malayi	Thioredoxin reductase	0.0083	0.0257	0.0605
Plasmodium falciparum	thioredoxin reductase	0.0029	0.0018	0.055
Brugia malayi	Zinc knuckle family protein	0.0052	0.0121	0.0285
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0035	0.0046	0.0066
Trypanosoma brucei	dihydrolipoamide dehydrogenase, point mutation	0.0029	0.0018	0.0018
Brugia malayi	reverse transcriptase	0.0052	0.0121	0.0285
Loa Loa (eye worm)	thioredoxin reductase	0.0083	0.0257	0.0605
Brugia malayi	Pao retrotransposon peptidase family protein	0.0052	0.0121	0.0285
Giardia lamblia	Reverse transcriptase/endonuclease, putative	0.0052	0.0121	0.0243
Trichomonas vaginalis	reverse transcriptase [C. elegans], putative	0.0052	0.0121	0.0243
Loa Loa (eye worm)	hypothetical protein	0.0101	0.0334	0.0788
Brugia malayi	Carbonic anhydrase like protein 2 precursor	0.0101	0.0334	0.0788
Loa Loa (eye worm)	glutathione reductase	0.0083	0.0257	0.0605
Mycobacterium ulcerans	dihydrolipoamide dehydrogenase, LpdB	0.0029	0.0018	0.5
Trichomonas vaginalis	CMGC family protein kinase	0.099	0.4244	1
Entamoeba histolytica	hypothetical protein	0.0035	0.0046	0.5
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.0029	0.0018	0.0043
Giardia lamblia	Reverse transcriptase/endonuclease, putative	0.0052	0.0121	0.0243
Brugia malayi	Eukaryotic-type carbonic anhydrase family protein	0.0101	0.0334	0.0788
Mycobacterium tuberculosis	NADPH-dependent mycothiol reductase Mtr	0.0083	0.0257	0.2985
Trypanosoma cruzi	ribonuclease H1, putative	0.0613	0.2587	0.6097
Brugia malayi	Pao retrotransposon peptidase family protein	0.0052	0.0121	0.0285
Echinococcus multilocularis	geminin	0.0165	0.0618	0.1419
Echinococcus granulosus	thioredoxin glutathione reductase	0.0084	0.0259	0.0569
Brugia malayi	Eukaryotic-type carbonic anhydrase family protein	0.0101	0.0334	0.0788
Trypanosoma brucei	unspecified product	0.0666	0.2816	0.2816
Brugia malayi	Pao retrotransposon peptidase family protein	0.0052	0.0121	0.0285
Echinococcus multilocularis	RNA directed DNA polymerase (reverse transcriptase)	0.0052	0.0121	0.0243
Brugia malayi	Putative carbonic anhydrase 5 precursor	0.0214	0.0834	0.1964
Schistosoma mansoni	carbonic anhydrase II (carbonate dehydratase II)	0.0214	0.0834	0.0817
Mycobacterium tuberculosis	Possible maturase	0.0052	0.0121	0.1285
Loa Loa (eye worm)	CMGC/MAPK/ERK1 protein kinase	0.099	0.4244	1
Leishmania major	ribonuclease H1, putative	0.0613	0.2587	0.6097
Schistosoma mansoni	carbonic anhydrase-related	0.0101	0.0334	0.0317
Mycobacterium tuberculosis	Probable dehydrogenase	0.0189	0.0724	0.8837
Brugia malayi	RNase H family protein	0.0613	0.2587	0.6097
Trypanosoma cruzi	mitogen activated protein kinase 4, putative	0.099	0.4244	1
Schistosoma mansoni	hypothetical protein	0.0035	0.0046	0.0028
Trypanosoma brucei	Endonuclease-reverse transcriptase/Reverse transcriptase (RNA-dependent DNA polymerase), putative	0.0052	0.0121	0.0121
Giardia lamblia	Ribonuclease H	0.0613	0.2587	0.608
Trypanosoma cruzi	hypothetical protein, conserved	0.0052	0.0121	0.0285
Echinococcus multilocularis	RNA directed DNA polymerase (reverse transcriptase)	0.0052	0.0121	0.0243
Plasmodium falciparum	dihydrolipoyl dehydrogenase, apicoplast	0.0029	0.0018	0.055
Brugia malayi	Eukaryotic-type carbonic anhydrase family protein	0.0101	0.0334	0.0788
Trypanosoma brucei	ingi protein (ORF1)	0.0666	0.2816	0.2816
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0035	0.0046	0.0066
Trypanosoma cruzi	carbonic anhydrase-like protein, putative	0.0214	0.0834	0.1964
Giardia lamblia	Reverse transcriptase/endonuclease, putative	0.0052	0.0121	0.0243
Mycobacterium tuberculosis	Probable membrane NADH dehydrogenase NdhA	0.0189	0.0724	0.8837
Mycobacterium tuberculosis	NAD(P)H quinone reductase LpdA	0.021	0.0817	1
Schistosoma mansoni	hypothetical protein	0.0052	0.0121	0.0103
Brugia malayi	Pao retrotransposon peptidase family protein	0.0052	0.0121	0.0285
Trypanosoma cruzi	trypanothione reductase, putative	0.0029	0.0018	0.0043
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.0029	0.0018	0.0043
Mycobacterium leprae	DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE	0.021	0.0817	1
Trypanosoma brucei	retrotransposon hot spot protein 4 (RHS4), interrupted	0.0666	0.2816	0.2816
Schistosoma mansoni	hypothetical protein	0.0052	0.0121	0.0103
Echinococcus multilocularis	RNA directed DNA polymerase	0.0052	0.0121	0.0243
Echinococcus multilocularis	RNA directed DNA polymerase (reverse transcriptase)	0.0052	0.0121	0.0243
Mycobacterium tuberculosis	Putative ferredoxin reductase	0.0189	0.0724	0.8837
Toxoplasma gondii	CMGC kinase, MAPK family (ERK) MAPK-1	0.099	0.4244	1
Treponema pallidum	ribonuclease H (rnhA)	0.0613	0.2587	1
Plasmodium vivax	dihydrolipoyl dehydrogenase, mitochondrial, putative	0.0029	0.0018	0.0716
Echinococcus granulosus	RNA directed DNA polymerase reverse transcriptase	0.0052	0.0121	0.0243
Leishmania major	mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440	0.099	0.4244	1
Brugia malayi	Pao retrotransposon peptidase family protein	0.0052	0.0121	0.0285
Leishmania major	carbonic anhydrase-like protein	0.0214	0.0834	0.1964
Schistosoma mansoni	serine/threonine protein kinase	0.099	0.4244	0.4233
Brugia malayi	hypothetical protein	0.0052	0.0121	0.0285
Leishmania major	dihydrolipoamide dehydrogenase, putative	0.0029	0.0018	0.0043
Echinococcus multilocularis	carbonic anhydrase	0.0101	0.0334	0.0748
Schistosoma mansoni	carbonic anhydrase-related	0.0101	0.0334	0.0317
Echinococcus multilocularis	mitogen activated protein kinase 3	0.099	0.4244	1
Leishmania major	acetoin dehydrogenase e3 component-like protein	0.0029	0.0018	0.0043
Plasmodium vivax	thioredoxin reductase, putative	0.0083	0.0257	1
Trypanosoma brucei	dihydrolipoamide dehydrogenase	0.0029	0.0018	0.0018
Trypanosoma brucei	mitogen activated protein kinase 4, putative	0.099	0.4244	0.4244
Brugia malayi	RNase H family protein	0.0613	0.2587	0.6097
Giardia lamblia	Reverse transcriptase/endonuclease, putative	0.0052	0.0121	0.0243
Trypanosoma cruzi	dihydrolipoyl dehydrogenase, putative	0.0029	0.0018	0.0043
Schistosoma mansoni	hypothetical protein	0.0101	0.0334	0.0317
Mycobacterium tuberculosis	Probable NADH dehydrogenase Ndh	0.0189	0.0724	0.8837
Trichomonas vaginalis	ribonuclease H1, putative	0.0613	0.2587	0.608
Echinococcus multilocularis	RNA directed DNA polymerase (reverse transcriptase)	0.0052	0.0121	0.0243
Schistosoma mansoni	transcription factor LCR-F1	0.0035	0.0046	0.0028
Trypanosoma brucei	SLACS retrotransposable element (part), putative	0.0052	0.0121	0.0121
Brugia malayi	reverse transcriptase	0.0052	0.0121	0.0285

Activities

Activity type	Activity value	Assay description	Source	Reference
Ki (binding)	= 73 nM	Binding affinity against human carbonic anhydrase II (hCA -II)	ChEMBL.	11425561
Ki (binding)	= 73 nM	Binding affinity against human carbonic anhydrase II (hCA -II)	ChEMBL.	11425561
Ki (binding)	= 150 nM	Compound was evaluated for binding affinity against bovine carbonic anhydrase IV (bCA IV)	ChEMBL.	11425561
Ki (binding)	= 150 nM	Compound was evaluated for binding affinity against bovine carbonic anhydrase IV (bCA IV)	ChEMBL.	11425561
Ki (binding)	= 425 nM	Binding affinity against human carbonic anhydrase I (hCA I)	ChEMBL.	11425561
Ki (binding)	= 425 nM	Binding affinity against human carbonic anhydrase I (hCA I)	ChEMBL.	11425561

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL50921

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 74133