Detailed information for compound 75356

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 351.46 | Formula: C18H25NO4S
  • H donors: 2 H acceptors: 4 LogP: 3.14 Rotable bonds: 9
    Rule of 5 violations (Lipinski): 1
  • SMILES: OC(=O)CCC/C=C\C[C@H]1CCC[C@H]1NS(=O)(=O)c1ccccc1
  • InChi: 1S/C18H25NO4S/c20-18(21)14-7-2-1-4-9-15-10-8-13-17(15)19-24(22,23)16-11-5-3-6-12-16/h1,3-6,11-12,15,17,19H,2,7-10,13-14H2,(H,20,21)/b4-1-/t15-,17+/m0/s1
  • InChiKey: QIXPVYQKDOIRDE-PTZWAXEDSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens thromboxane A2 receptor Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus G protein coupled receptor 139 0.0011 0.0567 0.0567
Brugia malayi hypothetical protein 0.0011 0.0567 0.0852
Echinococcus multilocularis neuropeptide receptor 0.0011 0.0567 0.0567
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0011 0.0567 0.0567
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0011 0.0567 0.0567
Echinococcus granulosus neuropeptide Y receptor 0.0011 0.0567 0.0567
Schistosoma mansoni growth hormone secretagogue receptor 0.0011 0.0567 0.0567
Brugia malayi hypothetical protein 0.0011 0.0567 0.0852
Echinococcus granulosus expressed protein 0.001 0.0459 0.0459
Loa Loa (eye worm) hypothetical protein 0.0011 0.0567 0.0567
Echinococcus multilocularis rhodopsin orphan GPCR 0.0011 0.0567 0.0567
Trichomonas vaginalis ras-dva small GTPase, putative 0.0067 0.6651 1
Trichomonas vaginalis cyclin B, putative 0.0021 0.1635 0.1899
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0011 0.0567 0.0567
Onchocerca volvulus Bile acid receptor homolog 0.0011 0.0567 0.0002
Echinococcus multilocularis cyclins 0.0021 0.1635 0.1635
Brugia malayi hypothetical protein 0.0036 0.3285 0.4939
Echinococcus multilocularis neuropeptide s receptor 0.0011 0.0567 0.0567
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0011 0.0567 0.0567
Echinococcus multilocularis G2:mitotic specific cyclin B3 0.0021 0.1635 0.1635
Echinococcus multilocularis thyroid hormone receptor alpha 0.0011 0.0567 0.0567
Loa Loa (eye worm) steroid hormone receptor 0.0011 0.0567 0.0567
Brugia malayi Dopamine receptor protein 1 0.0011 0.0567 0.0852
Schistosoma mansoni axis inhibition protein axin 0.001 0.0459 0.0459
Schistosoma mansoni nuclear hormone receptor 0.0011 0.0567 0.0567
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0011 0.0567 0.0567
Echinococcus multilocularis neuropeptides capa receptor 0.0011 0.0567 0.0567
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0011 0.0567 0.0567
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0011 0.0567 0.0567
Schistosoma mansoni neuropeptide receptor 0.0011 0.0567 0.0567
Echinococcus granulosus rhodopsin orphan GPCR 0.0011 0.0567 0.0567
Schistosoma mansoni hypothetical protein 0.0011 0.0567 0.0567
Trichomonas vaginalis rheb, putative 0.0067 0.6651 1
Echinococcus granulosus neuropeptide Y receptor 0.0011 0.0567 0.0567
Trichomonas vaginalis ubiquitin, putative 0.0036 0.3285 0.4564
Echinococcus granulosus FTZ F1 alpha 0.0011 0.0567 0.0567
Echinococcus granulosus axis inhibition protein axin 0.001 0.0459 0.0459
Loa Loa (eye worm) hypothetical protein 0.0011 0.0567 0.0567
Echinococcus multilocularis sex peptide receptor 0.0011 0.0567 0.0567
Loa Loa (eye worm) hypothetical protein 0.0011 0.0567 0.0567
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0011 0.0567 0.0567
Brugia malayi putative neuropeptide receptor 0.0011 0.0567 0.0852
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0011 0.0567 0.0853
Trichomonas vaginalis conserved hypothetical protein 0.0036 0.3285 0.4564
Echinococcus multilocularis allatostatin A receptor 0.0011 0.0567 0.0567
Schistosoma mansoni neuropeptide F-like receptor 0.0011 0.0567 0.0567
Brugia malayi RE15519p 0.0011 0.0567 0.0852
Echinococcus granulosus hypothetical protein 0.0011 0.0567 0.0567
Entamoeba histolytica cyclin, putative 0.0021 0.1635 0.1899
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0011 0.0567 0.0002
Echinococcus granulosus neuropeptide receptor 0.0011 0.0567 0.0567
Loa Loa (eye worm) G-protein coupled receptor 0.0011 0.0567 0.0567
Echinococcus multilocularis expressed protein 0.001 0.0459 0.0459
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0011 0.0567 0.0567
Echinococcus multilocularis axis inhibition protein axin 0.001 0.0459 0.0459
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0011 0.0567 0.0567
Entamoeba histolytica ras-1, putative 0.0067 0.6651 1
Brugia malayi Ras-related protein R-Ras2 0.0067 0.6651 1
Echinococcus granulosus cyclins 0.0021 0.1635 0.1635
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.1635 0.1899
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0011 0.0567 0.0567
Echinococcus multilocularis somatostatin receptor 0.0011 0.0567 0.0567
Loa Loa (eye worm) hypothetical protein 0.0011 0.0567 0.0567
Brugia malayi Steroid receptor seven-up type 2 0.0011 0.0567 0.0853
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0011 0.0567 0.0567
Schistosoma mansoni adenoreceptor 0.0011 0.0567 0.0567
Echinococcus multilocularis g protein coupled receptor 0.0011 0.0567 0.0567
Loa Loa (eye worm) hypothetical protein 0.0011 0.0567 0.0567
Brugia malayi Tachykinin-like peptides receptor 99D 0.0011 0.0567 0.0852
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0011 0.0567 0.0567
Loa Loa (eye worm) hypothetical protein 0.0011 0.0567 0.0567
Brugia malayi hypothetical protein 0.0011 0.0567 0.0852
Loa Loa (eye worm) hypothetical protein 0.0011 0.0567 0.0567
Trichomonas vaginalis conserved hypothetical protein 0.0059 0.5714 0.8486
Schistosoma mansoni hypothetical protein 0.0011 0.0567 0.0567
Echinococcus granulosus alpha 1A adrenergic receptor 0.0011 0.0567 0.0567
Echinococcus granulosus sex peptide receptor 0.0011 0.0567 0.0567
Echinococcus granulosus rhodopsin orphan GPCR 0.0011 0.0567 0.0567
Trichomonas vaginalis cyclin B, putative 0.0021 0.1635 0.1899
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0011 0.0567 0.0567
Echinococcus multilocularis g protein coupled receptor 0.0011 0.0567 0.0567
Echinococcus multilocularis fmrfamide receptor 0.0011 0.0567 0.0567
Loa Loa (eye worm) AGC/GRK/BARK protein kinase 0.0098 1 1
Echinococcus granulosus cyclins 0.0021 0.1635 0.1635
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0011 0.0567 0.0567
Loa Loa (eye worm) hypothetical protein 0.0011 0.0567 0.0567
Loa Loa (eye worm) hypothetical protein 0.0011 0.0567 0.0567
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0011 0.0567 0.0567
Echinococcus granulosus neuropeptides capa receptor 0.0011 0.0567 0.0567
Brugia malayi PXA domain containing protein 0.001 0.0459 0.069
Loa Loa (eye worm) hypothetical protein 0.0011 0.0567 0.0567
Brugia malayi Cyclin, N-terminal domain containing protein 0.0021 0.1635 0.2458
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0011 0.0567 0.0853
Loa Loa (eye worm) hypothetical protein 0.0011 0.0567 0.0567
Echinococcus granulosus Small ubiquitin modifier 2 0.0059 0.5714 0.5714
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0011 0.0567 0.0852
Echinococcus granulosus 7tm_1 domain containing protein 0.0011 0.0567 0.0567
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0011 0.0567 0.0567
Trichomonas vaginalis cyclins, putative 0.0021 0.1635 0.1899
Onchocerca volvulus 0.0036 0.3285 1
Trichomonas vaginalis GTP-binding protein rit, putative 0.0067 0.6651 1
Schistosoma mansoni thyroid hormone receptor 0.0011 0.0567 0.0567
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0011 0.0567 0.0567
Brugia malayi PXA domain containing protein 0.001 0.0459 0.069
Loa Loa (eye worm) hypothetical protein 0.0011 0.0567 0.0567
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0011 0.0567 0.0567
Brugia malayi GnHR receptor homolog 0.0011 0.0567 0.0852
Schistosoma mansoni steroid hormone receptor ad4bp 0.0011 0.0567 0.0567
Loa Loa (eye worm) hypothetical protein 0.0011 0.0567 0.0567
Echinococcus granulosus neuropeptide receptor A26 0.0011 0.0567 0.0567
Brugia malayi hypothetical protein 0.0011 0.0567 0.0852
Loa Loa (eye worm) hypothetical protein 0.0011 0.0567 0.0567
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.001 0.0459 0.0459
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0011 0.0567 0.0567
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0011 0.0567 0.0567
Schistosoma mansoni hypothetical protein 0.0011 0.0567 0.0567
Schistosoma mansoni neuropeptide f receptor 76f 0.0011 0.0567 0.0567
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0011 0.0567 0.0567
Schistosoma mansoni cyclin B 0.0021 0.1635 0.1635
Echinococcus granulosus biogenic amine 5HT receptor 0.0011 0.0567 0.0567
Brugia malayi Ubiquitin-like protein SMT3 0.0059 0.5714 0.8591
Schistosoma mansoni serine/threonine protein kinase 0.0098 1 1
Loa Loa (eye worm) hypothetical protein 0.0011 0.0567 0.0567
Echinococcus granulosus ecdysone induced protein 78C 0.0011 0.0567 0.0567
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0011 0.0567 0.0567
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0011 0.0567 0.0567
Brugia malayi hypothetical protein 0.0011 0.0567 0.0852
Loa Loa (eye worm) hypothetical protein 0.0011 0.0567 0.0567
Trichomonas vaginalis cyclins, putative 0.0021 0.1635 0.1899
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0011 0.0567 0.0567
Schistosoma mansoni biogenic amine (5HT) receptor 0.0011 0.0567 0.0567
Trypanosoma cruzi small ubiquitin protein, putative 0.0059 0.5714 1
Schistosoma mansoni biogenic amine receptor 0.0011 0.0567 0.0567
Brugia malayi photoreceptor-specific nuclear receptor 0.0011 0.0567 0.0853
Echinococcus multilocularis cyclins 0.0021 0.1635 0.1635
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0011 0.0567 0.0567
Loa Loa (eye worm) neuropeptide F receptor 0.0011 0.0567 0.0567
Loa Loa (eye worm) hypothetical protein 0.0011 0.0567 0.0567
Brugia malayi neuropeptide F receptor 0.0011 0.0567 0.0852
Echinococcus granulosus biogenic amine 5HT receptor 0.0011 0.0567 0.0567
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0011 0.0567 0.0567
Loa Loa (eye worm) hypothetical protein 0.0011 0.0567 0.0567
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.001 0.0459 0.0459
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0011 0.0567 0.0567
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0011 0.0567 0.0567
Echinococcus granulosus regulator of G protein signaling 7 0.001 0.0459 0.0459
Trichomonas vaginalis cyclin B, putative 0.0021 0.1635 0.1899
Loa Loa (eye worm) hypothetical protein 0.0011 0.0567 0.0567
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0011 0.0567 0.0567
Loa Loa (eye worm) hypothetical protein 0.0011 0.0567 0.0567
Schistosoma mansoni amine GPCR 0.0011 0.0567 0.0567
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0011 0.0567 0.0567
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0011 0.0567 0.0852
Brugia malayi hypothetical protein 0.0011 0.0567 0.0852
Echinococcus multilocularis ubiquitin 0.0036 0.3285 0.3285
Schistosoma mansoni regulator of G protein signaling 0.001 0.0459 0.0459
Loa Loa (eye worm) SMO-1 protein 0.0059 0.5714 0.5714
Schistosoma mansoni regulator of G protein signaling 0.001 0.0459 0.0459
Entamoeba histolytica Ras family GTPase 0.0067 0.6651 1
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0011 0.0567 0.0567
Onchocerca volvulus 0.0021 0.1635 0.393
Loa Loa (eye worm) hypothetical protein 0.0011 0.0567 0.0567
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0011 0.0567 0.0567
Echinococcus granulosus cyclin B3 1 0.0021 0.1635 0.1635
Trichomonas vaginalis cyclin D, putative 0.0021 0.1635 0.1899
Echinococcus multilocularis rhodopsin orphan GPCR 0.0011 0.0567 0.0567
Trichomonas vaginalis ral, putative 0.0067 0.6651 1
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0011 0.0567 0.0567
Echinococcus multilocularis orexin receptor type 2 0.0011 0.0567 0.0567
Brugia malayi neuropeptide F receptor 0.0011 0.0567 0.0852
Echinococcus multilocularis rhodopsin orphan GPCR 0.0011 0.0567 0.0567
Echinococcus granulosus tachykinin peptides receptor 99D 0.0011 0.0567 0.0567
Echinococcus multilocularis fmrfamide receptor 0.0011 0.0567 0.0567
Brugia malayi ecdysteroid receptor 0.0011 0.0567 0.0853
Echinococcus multilocularis regulator of G protein signaling 3 0.001 0.0459 0.0459
Echinococcus multilocularis axis inhibition protein axin 0.001 0.0459 0.0459
Echinococcus multilocularis Regulator of G protein signaling 20 0.001 0.0459 0.0459
Brugia malayi Cyclin, N-terminal domain containing protein 0.0021 0.1635 0.2458
Loa Loa (eye worm) hypothetical protein 0.0011 0.0567 0.0567
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0011 0.0567 0.0852
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0011 0.0567 0.0567
Entamoeba histolytica Ras family GTPase 0.0067 0.6651 1
Echinococcus multilocularis beta adrenergic receptor kinase 0.0098 1 1
Echinococcus multilocularis cyclins 0.0021 0.1635 0.1635
Echinococcus granulosus rhodopsin orphan GPCR 0.0011 0.0567 0.0567
Loa Loa (eye worm) hypothetical protein 0.0011 0.0567 0.0567
Loa Loa (eye worm) hypothetical protein 0.001 0.0459 0.0459
Loa Loa (eye worm) hypothetical protein 0.0011 0.0567 0.0567
Brugia malayi Cyclin, N-terminal domain containing protein 0.0021 0.1635 0.2458
Entamoeba histolytica cyclin family protein 0.0021 0.1635 0.1899
Schistosoma mansoni myosin xvIII 0.0011 0.0567 0.0567
Brugia malayi nuclear receptor NHR-88 0.0011 0.0567 0.0853
Brugia malayi Serotonin receptor 0.0011 0.0567 0.0852
Echinococcus granulosus tm gpcr rhodopsin 0.0011 0.0567 0.0567
Echinococcus granulosus g-protein coupled receptor 0.0011 0.0567 0.0567
Echinococcus multilocularis cyclins 0.0021 0.1635 0.1635
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0011 0.0567 0.0853
Echinococcus multilocularis neuropeptide FF receptor 2 0.0011 0.0567 0.0567
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0011 0.0567 0.0853
Loa Loa (eye worm) hypothetical protein 0.0011 0.0567 0.0567
Loa Loa (eye worm) PXA domain-containing protein 0.001 0.0459 0.0459
Loa Loa (eye worm) hypothetical protein 0.0011 0.0567 0.0567
Loa Loa (eye worm) melatonin receptor type 1A 0.0011 0.0567 0.0567
Loa Loa (eye worm) hypothetical protein 0.0011 0.0567 0.0567
Brugia malayi Serotonin receptor 0.0011 0.0567 0.0852
Schistosoma mansoni cyclin B3 0.0021 0.1635 0.1635
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0011 0.0567 0.0567
Echinococcus multilocularis regulator of G protein signaling 7 0.001 0.0459 0.0459
Echinococcus granulosus ras gtpase 0.0067 0.6651 0.6651
Brugia malayi Dopamine receptor protein 2 0.0011 0.0567 0.0852
Loa Loa (eye worm) TYRA-2 protein 0.0011 0.0567 0.0567
Echinococcus granulosus cyclin b3 0.0021 0.1635 0.1635
Loa Loa (eye worm) hypothetical protein 0.0021 0.1635 0.1635
Schistosoma mansoni neuropeptide receptor 0.0011 0.0567 0.0567
Echinococcus granulosus neuropeptide receptor 0.0011 0.0567 0.0567
Loa Loa (eye worm) hypothetical protein 0.0011 0.0567 0.0567
Brugia malayi Ras protein let-60 0.0067 0.6651 1
Loa Loa (eye worm) hypothetical protein 0.0011 0.0567 0.0567
Echinococcus multilocularis A kinase anchor protein 10, mitochondrial 0.001 0.0459 0.0459
Trichomonas vaginalis cyclin B, putative 0.0021 0.1635 0.1899
Echinococcus granulosus regulator of G protein signaling 7 0.001 0.0459 0.0459
Schistosoma mansoni retinoic acid receptor RXR 0.0011 0.0567 0.0567
Echinococcus multilocularis neuropeptide Y receptor 0.0011 0.0567 0.0567
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0011 0.0567 0.0567
Schistosoma mansoni hypothetical protein 0.0011 0.0567 0.0567
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0011 0.0567 0.0567
Plasmodium vivax small ubiquitin-related modifier, putative 0.0059 0.5714 0.5
Echinococcus granulosus G2:mitotic specific cyclin B3 0.0021 0.1635 0.1635
Schistosoma mansoni biogenic amine (5HT) receptor 0.0011 0.0567 0.0567
Brugia malayi hypothetical protein 0.0011 0.0567 0.0852
Toxoplasma gondii small ubiquitin family modifier, putative 0.0059 0.5714 1
Brugia malayi Melatonin receptor type 1A 0.0011 0.0567 0.0852
Loa Loa (eye worm) G-protein coupled receptor 0.0011 0.0567 0.0567
Trichomonas vaginalis dexras1, putative 0.0067 0.6651 1
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0011 0.0567 0.0567
Echinococcus multilocularis cyclin B 0.0021 0.1635 0.1635
Echinococcus granulosus cyclins 0.0021 0.1635 0.1635
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0011 0.0567 0.0567
Brugia malayi A-kinase anchor protein 10, precursor 0.001 0.0459 0.069
Brugia malayi Regulator of G protein signaling domain containing protein 0.001 0.0459 0.069
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0011 0.0567 0.0567
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0011 0.0567 0.0567
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0011 0.0567 0.0567
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0011 0.0567 0.0567
Loa Loa (eye worm) hypothetical protein 0.0011 0.0567 0.0567
Echinococcus multilocularis serotonin receptor 0.0011 0.0567 0.0567
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0011 0.0567 0.0567
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0011 0.0567 0.0853
Trichomonas vaginalis cyclin B3, putative 0.0021 0.1635 0.1899
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0011 0.0567 0.0567
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0011 0.0567 0.0567
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0011 0.0567 0.0567
Echinococcus granulosus neuropeptide FF receptor 2 0.0011 0.0567 0.0567
Loa Loa (eye worm) hypothetical protein 0.001 0.0459 0.0459
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0011 0.0567 0.0567
Trypanosoma brucei small ubiquitin-related modifier 0.0059 0.5714 1
Schistosoma mansoni cyclins 0.0021 0.1635 0.1635
Schistosoma mansoni amine GPCR 0.0011 0.0567 0.0567
Echinococcus granulosus Regulator of G protein signaling 20 0.001 0.0459 0.0459
Brugia malayi Nuclear hormone receptor-like 1 0.0011 0.0567 0.0853
Echinococcus granulosus 7TM GPCR rhodopsin 0.0011 0.0567 0.0567
Loa Loa (eye worm) hypothetical protein 0.0021 0.1635 0.1635
Schistosoma mansoni biogenic amine receptor 0.0011 0.0567 0.0567
Echinococcus multilocularis dro:myosuppressin receptor 0.0011 0.0567 0.0567
Trichomonas vaginalis cyclins, putative 0.0021 0.1635 0.1899
Brugia malayi hypothetical protein 0.0011 0.0567 0.0852
Loa Loa (eye worm) hypothetical protein 0.0011 0.0567 0.0567
Echinococcus granulosus rhodopsin orphan GPCR 0.0011 0.0567 0.0567
Loa Loa (eye worm) cyclin domain-containing protein 0.0021 0.1635 0.1635
Brugia malayi regulator of G-protein signaling rgs-7 0.001 0.0459 0.069
Schistosoma mansoni biogenic amine receptor 0.0011 0.0567 0.0567
Echinococcus multilocularis neuropeptides capa receptor 0.0011 0.0567 0.0567
Schistosoma mansoni z-protein (S1r protein) 0.001 0.0459 0.0459
Schistosoma mansoni regulator of G protein signaling 3 rgs3 0.001 0.0459 0.0459
Schistosoma mansoni ubiquitin-like protein sumo/smt3-related 0.0059 0.5714 0.5714
Brugia malayi hypothetical protein 0.001 0.0459 0.069
Echinococcus granulosus dro:myosuppressin receptor 0.0011 0.0567 0.0567
Echinococcus granulosus somatostatin receptor 0.0011 0.0567 0.0567
Loa Loa (eye worm) AGC/GRK/GRK protein kinase 0.0011 0.0544 0.0544
Echinococcus granulosus G protein coupled receptor kinase 1 0.0088 0.8906 0.8906
Brugia malayi ORL1-like opioid receptor 0.0011 0.0567 0.0852
Loa Loa (eye worm) hypothetical protein 0.0011 0.0567 0.0567
Schistosoma mansoni serine/threonine protein kinase 0.0098 1 1
Brugia malayi regulator of G-protein signaling egl-10 0.001 0.0459 0.069
Schistosoma mansoni regulator of G protein signaling 0.001 0.0459 0.0459
Schistosoma mansoni thyroid hormone receptor 0.0011 0.0567 0.0567
Echinococcus multilocularis ras gtpase 0.0067 0.6651 0.6651
Echinococcus granulosus rhodopsin orphan GPCR 0.0011 0.0567 0.0567
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0011 0.0567 0.0567
Loa Loa (eye worm) hypothetical protein 0.0011 0.0567 0.0567
Echinococcus multilocularis regulator of G protein signaling 7 0.001 0.0459 0.0459
Loa Loa (eye worm) hypothetical protein 0.0011 0.0567 0.0567
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0011 0.0567 0.0853
Echinococcus granulosus ubiquitin 0.0036 0.3285 0.3285
Schistosoma mansoni coup transcription factor 0.0011 0.0567 0.0567
Loa Loa (eye worm) hypothetical protein 0.001 0.0459 0.0459
Brugia malayi Probable G protein-coupled receptor kinase F19C6.1, putative 0.0011 0.0544 0.0819
Echinococcus granulosus tm gpcr rhodopsin 0.0011 0.0567 0.0567
Schistosoma mansoni amine GPCR 0.0011 0.0567 0.0567
Echinococcus granulosus allatostatin A receptor 0.0011 0.0567 0.0567
Echinococcus multilocularis g protein coupled receptor 0.0011 0.0567 0.0567
Echinococcus multilocularis rhodopsin orphan GPCR 0.0011 0.0567 0.0567
Echinococcus granulosus neuropeptides capa receptor 0.0011 0.0567 0.0567
Brugia malayi steroid hormone receptor 0.0011 0.0567 0.0853
Schistosoma mansoni amine GPCR 0.0011 0.0567 0.0567
Plasmodium falciparum small ubiquitin-related modifier 0.0059 0.5714 1
Brugia malayi hypothetical protein 0.0011 0.0567 0.0852
Echinococcus granulosus rhodopsin orphan GPCR 0.0011 0.0567 0.0567
Loa Loa (eye worm) hypothetical protein 0.0011 0.0567 0.0567
Loa Loa (eye worm) hypothetical protein 0.0011 0.0567 0.0567
Echinococcus multilocularis regulator of G protein signaling 3 0.001 0.0459 0.0459
Echinococcus granulosus cyclins 0.0021 0.1635 0.1635
Echinococcus multilocularis FTZ F1 alpha 0.0011 0.0567 0.0567
Echinococcus multilocularis G protein coupled receptor 139 0.0011 0.0567 0.0567
Giardia lamblia Sentrin 0.0059 0.5714 1
Loa Loa (eye worm) neuropeptide F receptor 0.0011 0.0567 0.0567
Echinococcus multilocularis cyclins 0.0021 0.1635 0.1635
Echinococcus granulosus fmrfamide receptor 0.0011 0.0567 0.0567
Brugia malayi AKH receptor 0.0011 0.0567 0.0852
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0011 0.0567 0.0567
Loa Loa (eye worm) Ras protein let-60 0.0067 0.6651 0.6651
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0011 0.0567 0.0853
Loa Loa (eye worm) hypothetical protein 0.0011 0.0567 0.0567
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0011 0.0567 0.0853
Trichomonas vaginalis rap1 and, putative 0.0067 0.6651 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0011 0.0567 0.0567
Schistosoma mansoni axis inhibition protein axin 0.001 0.0459 0.0459
Loa Loa (eye worm) hypothetical protein 0.0011 0.0567 0.0567
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0011 0.0567 0.0853
Schistosoma mansoni neuropeptide receptor 0.0011 0.0567 0.0567
Loa Loa (eye worm) hypothetical protein 0.0011 0.0567 0.0567
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0011 0.0567 0.0567
Schistosoma mansoni neuropeptide receptor 0.0011 0.0567 0.0567
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0011 0.0567 0.0567
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0011 0.0567 0.0567
Echinococcus multilocularis g-protein coupled receptor 0.0011 0.0567 0.0567
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0011 0.0567 0.0567
Loa Loa (eye worm) hypothetical protein 0.001 0.0459 0.0459
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0011 0.0567 0.0567
Trichomonas vaginalis cyclins, putative 0.0021 0.1635 0.1899
Echinococcus multilocularis G protein coupled receptor kinase 1 0.0088 0.8906 0.8906
Leishmania major small ubiquitin protein, putative 0.0059 0.5714 1
Echinococcus granulosus regulator of G protein signaling 3 0.001 0.0459 0.0459
Schistosoma mansoni regulator of G protein signaling 0.001 0.0459 0.0459
Schistosoma mansoni opsin-like receptor 0.0011 0.0567 0.0567
Echinococcus multilocularis rhodopsin orphan GPCR 0.0011 0.0567 0.0567
Echinococcus multilocularis neuropeptide Y receptor 0.0011 0.0567 0.0567
Schistosoma mansoni amine GPCR 0.0011 0.0567 0.0567
Loa Loa (eye worm) hypothetical protein 0.0011 0.0567 0.0567
Echinococcus multilocularis ecdysone induced protein 78C 0.0011 0.0567 0.0567
Brugia malayi nuclear hormone receptor 0.0011 0.0567 0.0853
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0011 0.0567 0.0567
Echinococcus multilocularis regulator of G protein signaling 0.001 0.0459 0.0459
Echinococcus multilocularis neuropeptide receptor 0.0011 0.0567 0.0567
Onchocerca volvulus 0.0011 0.0567 0.0002
Echinococcus granulosus A kinase anchor protein 10 mitochondrial 0.001 0.0459 0.0459
Entamoeba histolytica ubiquitin like protein 0.0059 0.5714 0.8486
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0011 0.0567 0.0567
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0011 0.0567 0.0853
Loa Loa (eye worm) hypothetical protein 0.0011 0.0567 0.0567
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0011 0.0567 0.0567
Echinococcus granulosus g protein coupled receptor 0.0011 0.0567 0.0567
Schistosoma mansoni regulator of G protein signaling 0.001 0.0459 0.0459
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0011 0.0567 0.0567
Loa Loa (eye worm) hypothetical protein 0.0011 0.0567 0.0567
Echinococcus granulosus regulator of G protein signaling 3 0.001 0.0459 0.0459
Echinococcus multilocularis cyclins 0.0021 0.1635 0.1635
Loa Loa (eye worm) hypothetical protein 0.001 0.0459 0.0459
Echinococcus multilocularis G-protein coupled receptor, putative 0.0011 0.0567 0.0567
Echinococcus multilocularis cyclin b3 0.0021 0.1635 0.1635
Loa Loa (eye worm) hypothetical protein 0.0011 0.0567 0.0567
Brugia malayi Regulator of G protein signaling domain containing protein 0.001 0.0459 0.069
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0011 0.0567 0.0567
Echinococcus multilocularis neuropeptide receptor A26 0.0011 0.0567 0.0567
Echinococcus granulosus serotonin receptor 0.0011 0.0567 0.0567
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0011 0.0567 0.0567
Brugia malayi Dopamine receptor 0.0011 0.0567 0.0852
Echinococcus granulosus g protein coupled receptor 0.0011 0.0567 0.0567
Loa Loa (eye worm) RGS-3 protein 0.001 0.0459 0.0459
Echinococcus multilocularis rhodopsin orphan GPCR 0.0011 0.0567 0.0567
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0011 0.0567 0.0567
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0011 0.0567 0.0567
Trichomonas vaginalis cyclin A, putative 0.0021 0.1635 0.1899
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0011 0.0567 0.0853
Echinococcus granulosus cyclins 0.0021 0.1635 0.1635
Loa Loa (eye worm) hypothetical protein 0.0011 0.0567 0.0567
Brugia malayi G protein-coupled receptor F59B2.13 0.0011 0.0567 0.0852
Brugia malayi putative neuropeptide receptor NPR1 0.0011 0.0567 0.0852
Echinococcus granulosus peptide allatostatin:somatostatin 0.0011 0.0567 0.0567
Loa Loa (eye worm) hypothetical protein 0.0011 0.0567 0.0567
Schistosoma mansoni opsin-like receptor 0.0011 0.0567 0.0567
Schistosoma mansoni serine/threonine protein kinase 0.0011 0.0544 0.0544
Brugia malayi follicle stimulating hormone receptor 0.0011 0.0567 0.0852
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0011 0.0567 0.0567
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0011 0.0567 0.0853
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0011 0.0567 0.0852
Schistosoma mansoni opsin-like receptor 0.0011 0.0567 0.0567
Brugia malayi G-protein coupled receptor 0.0011 0.0567 0.0852
Trichomonas vaginalis cyclin B, putative 0.0021 0.1635 0.1899
Trichomonas vaginalis cyclins, putative 0.0021 0.1635 0.1899
Loa Loa (eye worm) hypothetical protein 0.0036 0.3285 0.3285
Trichomonas vaginalis cyclin D, putative 0.0021 0.1635 0.1899
Loa Loa (eye worm) hypothetical protein 0.0011 0.0567 0.0567
Echinococcus multilocularis Small ubiquitin modifier 2 0.0059 0.5714 0.5714
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0011 0.0567 0.0852
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0011 0.0567 0.0567
Loa Loa (eye worm) hypothetical protein 0.0011 0.0567 0.0567
Entamoeba histolytica hypothetical protein 0.0036 0.3285 0.4564
Entamoeba histolytica cyclin, putative 0.0021 0.1635 0.1899
Echinococcus granulosus rhodopsin orphan GPCR 0.0011 0.0567 0.0567
Echinococcus granulosus cyclin B 0.0021 0.1635 0.1635
Echinococcus granulosus neuropeptide s receptor 0.0011 0.0567 0.0567
Entamoeba histolytica cyclin family protein 0.0021 0.1635 0.1899
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0011 0.0567 0.0567
Loa Loa (eye worm) hypothetical protein 0.0067 0.6651 0.6651
Echinococcus multilocularis cyclin B3 1 0.0021 0.1635 0.1635
Trypanosoma cruzi small ubiquitin protein, putative 0.0059 0.5714 1
Loa Loa (eye worm) hypothetical protein 0.0011 0.0567 0.0567
Schistosoma mansoni histamine h1 receptor 0.0011 0.0567 0.0567
Schistosoma mansoni neuropeptide F-like receptor 0.0011 0.0567 0.0567
Schistosoma mansoni alpha-1 adrenergic receptor 0.0011 0.0567 0.0567
Loa Loa (eye worm) hypothetical protein 0.0011 0.0567 0.0567
Loa Loa (eye worm) hypothetical protein 0.0011 0.0567 0.0567
Schistosoma mansoni RAR-like nuclear receptor 0.0011 0.0567 0.0567
Loa Loa (eye worm) hypothetical protein 0.001 0.0459 0.0459
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0011 0.0567 0.0567
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0011 0.0567 0.0567
Echinococcus multilocularis serotonin receptor 0.0011 0.0567 0.0567
Brugia malayi sulfakinin receptor protein 0.0011 0.0567 0.0852
Echinococcus granulosus tm gpcr rhodopsin 0.0011 0.0567 0.0567
Brugia malayi G protein-coupled receptor 0.0011 0.0567 0.0852
Echinococcus granulosus axis inhibition protein axin 0.001 0.0459 0.0459
Echinococcus granulosus g protein coupled receptor 0.0011 0.0567 0.0567
Loa Loa (eye worm) G protein signaling regulator EGL-10 0.001 0.0459 0.0459
Onchocerca volvulus Protein ultraspiracle homolog 0.0011 0.0567 0.0002
Echinococcus multilocularis cyclins 0.0021 0.1635 0.1635
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0011 0.0567 0.0567
Brugia malayi hypothetical protein 0.001 0.0459 0.069
Brugia malayi hypothetical protein 0.0011 0.0567 0.0852
Brugia malayi larval opioid receptor 0.0011 0.0567 0.0852
Loa Loa (eye worm) hypothetical protein 0.0011 0.0567 0.0567
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0011 0.0567 0.0567
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0011 0.0567 0.0567
Echinococcus granulosus orexin receptor type 2 0.0011 0.0567 0.0567
Loa Loa (eye worm) hypothetical protein 0.0011 0.0567 0.0567
Brugia malayi G-protein coupled receptor 0.0011 0.0567 0.0852
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0011 0.0567 0.0853
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0011 0.0567 0.0567
Loa Loa (eye worm) hypothetical protein 0.0011 0.0567 0.0567
Echinococcus multilocularis rhodopsin orphan GPCR 0.0011 0.0567 0.0567

Activities

Activity type Activity value Assay description Source Reference
IC50 (functional) = 250 nM Tested for concentration of the compound required for antagonism of U-46,619-Induced Human Platelet Aggregaion ChEMBL. No reference
IC50 (functional) = 250 nM Tested for concentration of the compound required for antagonism of U-46,619-Induced Human Platelet Aggregaion ChEMBL. No reference
Kd (binding) = 36 nM Tested for binding affinity against platelet TXA2 receptor in washed human platelets using [125I]-BOP as radioligand ChEMBL. No reference
Kd (binding) = 36 nM Tested for binding affinity against platelet TXA2 receptor in washed human platelets using [125I]-BOP as radioligand ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Homo sapiens ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.