TDR Targets

Basic information

Technical information

TDR Targets ID: 757627
Name: 3-[2-(1,3-benzodioxol-5-yl)-2-oxoethyl]-3-hyd roxy-1-propan-2-ylindol-2-one
MW: 353.369 | Formula: C20H19NO5
H donors: 1 H acceptors: 3 LogP: 2.7 Rotable bonds: 4
Rule of 5 violations (Lipinski): 1
SMILES: CC(N1c2ccccc2C(C1=O)(O)CC(=O)c1ccc2c(c1)OCO2)C
InChi: 1S/C20H19NO5/c1-12(2)21-15-6-4-3-5-14(15)20(24,19(21)23)10-16(22)13-7-8-17-18(9-13)26-11-25-17/h3-9,12,24H,10-11H2,1-2H3
InChiKey: YFJCUBSAFFXYBK-UHFFFAOYSA-N

Network

Hover on a compound node to display the structore

Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

This is a work in progress. Come back soon to try this features!

Clustering layers

This is a work in progress. Come back soon to try this features!

Synonyms

3-[2-(1,3-benzodioxol-5-yl)-2-oxo-ethyl]-3-hydroxy-1-isopropyl-indolin-2-one
3-[2-(1,3-benzodioxol-5-yl)-2-oxoethyl]-3-hydroxy-1-isopropyl-2-indolinone
3-[2-(1,3-benzodioxol-5-yl)-2-keto-ethyl]-3-hydroxy-1-isopropyl-oxindole
3-[2-(1,3-benzodioxol-5-yl)-2-oxo-ethyl]-3-hydroxy-1-propan-2-yl-indol-2-one
STK214543

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0131	0.024	0.024
Wolbachia endosymbiont of Brugia malayi	2,3,4,5-tetrahydropyridine-2,6-carboxylate N-succinyltransferase	0.0074	0.012	1
Entamoeba histolytica	carbonic anhydrase, putative	0.1522	0.3141	1
Entamoeba histolytica	hypothetical protein	0.0111	0.0198	0.0463
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0051	0.0051
Plasmodium vivax	sulfate transporter, putative	0.0034	0.0038	0.2875
Trypanosoma brucei	hypothetical protein, conserved	0.0042	0.0055	0.0055
Echinococcus multilocularis	atpase aaa+ type core atpase aaa type core	0.2624	0.544	0.544
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0032	0.0032
Mycobacterium tuberculosis	Probable lipase LipE	0.0041	0.0051	0.0242
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0048	0.0066	0.0066
Trypanosoma cruzi	PAB1-binding protein , putative	0.0079	0.0131	0.0131
Schistosoma mansoni	carbonic anhydrase II (carbonate dehydratase II)	0.481	1	1
Leishmania major	hypothetical protein, conserved	0.0042	0.0055	0.0055
Echinococcus granulosus	5'partial\|histone lysine N methyltransferase SETDB2	0.003	0.0029	0.0029
Schistosoma mansoni	histone-lysine n-methyltransferase suv9	0.0031	0.0032	0.0032
Mycobacterium ulcerans	transferase	0.0071	0.0115	0.0237
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0051	0.0051
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0131	0.024	0.024
Mycobacterium ulcerans	hypothetical protein	0.0041	0.0051	0.0041
Schistosoma mansoni	carbonic anhydrase-related	0.1811	0.3744	0.3744
Loa Loa (eye worm)	transcription factor SMAD2	0.0122	0.0221	0.0221
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0414	0.083	0.083
Schistosoma mansoni	carbonic anhydrase	0.1522	0.3141	0.3141
Entamoeba histolytica	ankyrin, putative	0.0074	0.012	0.0213
Echinococcus granulosus	beta LACTamase domain containing family member	0.0041	0.0051	0.0051
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0048	0.0066	0.0066
Mycobacterium ulcerans	lipase LipD	0.0041	0.0051	0.0041
Chlamydia trachomatis	sulfate transporter	0.0034	0.0038	0.5
Echinococcus multilocularis	histone lysine N methyltransferase SETMAR	0.0031	0.0032	0.0032
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0025	0.0025
Brugia malayi	Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative	0.0041	0.0051	0.0051
Entamoeba histolytica	acetyltransferase, putative	0.0074	0.012	0.0213
Brugia malayi	latrophilin 2 splice variant baaae	0.0283	0.0557	0.0557
Mycobacterium tuberculosis	Conserved protein	0.0041	0.0051	0.0242
Plasmodium falciparum	inorganic anion exchanger, inorganic anion antiporter	0.0034	0.0038	0.01
Trypanosoma brucei	Sulfate transporter N-terminal domain with GLY motif/Sulfate transporter family, putative	0.0034	0.0038	0.0038
Schistosoma mansoni	lamin	0.0028	0.0025	0.0025
Schistosoma mansoni	hypothetical protein	0.0131	0.024	0.024
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0048	0.0066	0.0066
Plasmodium vivax	ataxin-2 like protein, putative	0.0079	0.0131	1
Schistosoma mansoni	hypothetical protein	0.1811	0.3744	0.3744
Schistosoma mansoni	transcription factor LCR-F1	0.0111	0.0198	0.0198
Brugia malayi	Carbonic anhydrase like protein 2 precursor	0.1811	0.3744	0.3744
Echinococcus multilocularis	musashi	0.0028	0.0025	0.0025
Mycobacterium tuberculosis	Probable serine acetyltransferase CysE (sat)	0.0074	0.012	0.0574
Loa Loa (eye worm)	hypothetical protein	0.1811	0.3744	0.3744
Mycobacterium leprae	Probable transmembrane transport protein	0.0248	0.0483	0.14
Loa Loa (eye worm)	hypothetical protein	0.3054	0.6338	0.6338
Brugia malayi	hypothetical protein	0.0111	0.0198	0.0198
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0111	0.0198	0.0198
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0131	0.024	0.024
Plasmodium vivax	SET domain protein, putative	0.0031	0.0032	0.2425
Echinococcus multilocularis	Ataxin 2, N terminal,domain containing protein	0.0035	0.004	0.004
Echinococcus granulosus	GPCR family 2	0.0131	0.024	0.024
Trypanosoma cruzi	hypothetical protein, conserved	0.0041	0.0051	0.0051
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0041	0.0051	0.0051
Schistosoma mansoni	hypothetical protein	0.0283	0.0557	0.0557
Loa Loa (eye worm)	eukaryotic-type carbonic anhydrase	0.1811	0.3744	0.3744
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0051	0.0051
Brugia malayi	intermediate filament protein	0.0028	0.0025	0.0025
Wolbachia endosymbiont of Brugia malayi	N-acetylglucosamine-1-phosphate uridyltransferase	0.0074	0.012	1
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0031	0.0032	0.0032
Trypanosoma brucei	hypothetical protein, conserved	0.0041	0.0051	0.0051
Schistosoma mansoni	carbonic anhydrase-related	0.1811	0.3744	0.3744
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0414	0.083	0.083
Trichomonas vaginalis	maltose O-acetyltransferase, putative	0.0071	0.0115	0.0197
Mycobacterium ulcerans	carbonic anhydrase	0.1592	0.3288	1
Loa Loa (eye worm)	beta-lactamase	0.0041	0.0051	0.0051
Schistosoma mansoni	hypothetical protein	0.0035	0.004	0.004
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0111	0.0198	0.0198
Brugia malayi	Pre-SET motif family protein	0.0031	0.0032	0.0032
Trypanosoma cruzi	PAB1-binding protein , putative	0.0079	0.0131	0.0131
Trypanosoma cruzi	hypothetical protein, conserved	0.0041	0.0051	0.0051
Schistosoma mansoni	hypothetical protein	0.0131	0.024	0.024
Trypanosoma cruzi	hypothetical protein, conserved	0.0042	0.0055	0.0055
Loa Loa (eye worm)	beta-LACTamase domain containing family member	0.0041	0.0051	0.0051
Onchocerca volvulus	Putative sulfate transporter	0.0215	0.0414	0.8445
Mycobacterium tuberculosis	Probable esterase/lipase LipP	0.0041	0.0051	0.0242
Mycobacterium leprae	CARBONIC ANHYDRASE (CARBONATE DEHYDRATASE) (CARBONIC DEHYDRATASE)	0.1522	0.3141	1
Toxoplasma gondii	histone lysine methyltransferase SET/SUV39	0.0031	0.0032	0.0085
Schistosoma mansoni	hypothetical protein	0.0131	0.024	0.024
Mycobacterium ulcerans	fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE	0.0041	0.0051	0.0041
Entamoeba histolytica	hypothetical protein	0.0111	0.0198	0.0463
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0041	0.0051	0.0051
Schistosoma mansoni	hypothetical protein	0.0131	0.024	0.024
Plasmodium falciparum	ataxin-2 like protein, putative	0.0079	0.0131	0.0349
Brugia malayi	beta-lactamase family protein	0.0041	0.0051	0.0051
Trypanosoma cruzi	Sulfate transporter N-terminal domain with GLY motif/Sulfate transporter family, putative	0.0034	0.0038	0.0038
Loa Loa (eye worm)	hypothetical protein	0.0414	0.083	0.083
Trypanosoma brucei	carbonic anhydrase-like protein	0.481	1	1
Leishmania major	hypothetical protein, conserved	0.0079	0.0131	0.0131
Schistosoma mansoni	lamin	0.0028	0.0025	0.0025
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0024	0.0024
Plasmodium falciparum	ataxin-2 like protein, putative	0.0079	0.0131	0.0349
Schistosoma mansoni	carbonic anhydrase	0.1811	0.3744	0.3744
Loa Loa (eye worm)	intermediate filament protein	0.0028	0.0025	0.0025
Schistosoma mansoni	hypothetical protein	0.0875	0.1792	0.1792
Echinococcus granulosus	lamin dm0	0.0028	0.0025	0.0025
Loa Loa (eye worm)	hypothetical protein	0.0283	0.0557	0.0557
Brugia malayi	Latrophilin receptor protein 2	0.0131	0.024	0.024
Echinococcus granulosus	dynactin 5 p25	0.0074	0.012	0.012
Leishmania major	hypothetical protein, conserved	0.0041	0.0051	0.0051
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0131	0.024	0.024
Mycobacterium tuberculosis	Probable conserved lipoprotein	0.0041	0.0051	0.0242
Echinococcus multilocularis	carbonic anhydrase	0.1811	0.3744	0.3744
Mycobacterium tuberculosis	Probable lipase LipD	0.0041	0.0051	0.0242
Toxoplasma gondii	inorganic anion transporter, sulfate permease (SulP) family protein	0.0034	0.0038	0.01
Mycobacterium tuberculosis	Conserved protein	0.0041	0.0051	0.0242
Trypanosoma cruzi	carbonic anhydrase-like protein, putative	0.481	1	1
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0048	0.0066	0.0066
Toxoplasma gondii	ABC1 family protein	0.0041	0.0051	0.0136
Mycobacterium tuberculosis	Possible penicillin-binding protein	0.0259	0.0507	0.2416
Echinococcus multilocularis	lamin dm0	0.0028	0.0025	0.0025
Brugia malayi	Pax transcription factor protein 2	0.0247	0.0481	0.0481
Mycobacterium tuberculosis	Probable conserved transmembrane protein	0.0248	0.0483	0.2303
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.0243	0.0474	0.0474
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0048	0.0066	0.0066
Brugia malayi	Eukaryotic-type carbonic anhydrase family protein	0.1811	0.3744	0.3744
Echinococcus multilocularis	beta LACTamase domain containing family member	0.0041	0.0051	0.0051
Schistosoma mansoni	hypothetical protein	0.0875	0.1792	0.1792
Mycobacterium tuberculosis	Probable esterase LipL	0.0041	0.0051	0.0242
Brugia malayi	Pre-SET motif family protein	0.0219	0.0423	0.0423
Echinococcus granulosus	carbonic anhydrase	0.1811	0.3744	0.3744
Echinococcus multilocularis	geminin	0.0875	0.1792	0.1792
Brugia malayi	follicle stimulating hormone receptor	0.0243	0.0474	0.0474
Mycobacterium tuberculosis	Probable hydrolase	0.0041	0.0051	0.0242
Echinococcus granulosus	carbonic anhydrase	0.1811	0.3744	0.3744
Leishmania major	carbonic anhydrase family protein, putative	0.1522	0.3141	0.3141
Loa Loa (eye worm)	hypothetical protein	0.1811	0.3744	0.3744
Loa Loa (eye worm)	pre-SET domain-containing protein family protein	0.0219	0.0423	0.0423
Mycobacterium ulcerans	carbonic anhydrase	0.1522	0.3141	0.9547
Loa Loa (eye worm)	eukaryotic-type carbonic anhydrase	0.481	1	1
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0051	0.0051
Onchocerca volvulus		0.0249	0.0486	1
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0131	0.024	0.024
Echinococcus granulosus	Ataxin 2 N terminaldomain containing protein	0.0035	0.004	0.004
Mycobacterium leprae	PROBABLE TRANSFERASE	0.0071	0.0115	0.0206
Echinococcus multilocularis	carbonic anhydrase	0.1811	0.3744	0.3744
Trichomonas vaginalis	conserved hypothetical protein	0.0071	0.0115	0.0197
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0031	0.0032	0.0032
Echinococcus granulosus	histone lysine methyltransferase setb	0.0031	0.0032	0.0032
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0131	0.024	0.024
Toxoplasma gondii	LsmAD domain-containing protein	0.0079	0.0131	0.0349
Mycobacterium tuberculosis	Beta-carbonic anhydrase	0.1022	0.2099	1
Mycobacterium ulcerans	hypothetical protein	0.0042	0.0055	0.0053
Echinococcus granulosus	intermediate filament protein	0.0028	0.0025	0.0025
Brugia malayi	beta-lactamase family protein	0.0041	0.0051	0.0051
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0048	0.0066	0.0066
Onchocerca volvulus		0.0215	0.0414	0.8445
Loa Loa (eye worm)	hypothetical protein	0.0131	0.024	0.024
Echinococcus multilocularis	carbonic anhydrase	0.1811	0.3744	0.3744
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0048	0.0066	0.0066
Trypanosoma brucei	PAB1-binding protein , putative	0.0079	0.0131	0.0131
Onchocerca volvulus		0.0071	0.0115	0.1938
Mycobacterium ulcerans	esterase/lipase LipP	0.0041	0.0051	0.0041
Brugia malayi	Intermediate filament tail domain containing protein	0.0028	0.0025	0.0025
Loa Loa (eye worm)	carbonic anhydrase 3	0.481	1	1
Echinococcus multilocularis	lamin	0.0028	0.0025	0.0025
Onchocerca volvulus		0.0041	0.0051	0.0555
Loa Loa (eye worm)	pax transcription factor protein 2	0.0247	0.0481	0.0481
Trypanosoma cruzi	carbonic anhydrase-like protein, putative	0.481	1	1
Echinococcus multilocularis	carbonic anhydrase II	0.481	1	1
Brugia malayi	Carbonic anhydrase like protein 2 precursor	0.1811	0.3744	0.3744
Mycobacterium ulcerans	beta-lactamase	0.0041	0.0051	0.0041
Brugia malayi	hypothetical protein	0.0079	0.0131	0.0131
Brugia malayi	Putative carbonic anhydrase 5 precursor	0.481	1	1
Mycobacterium tuberculosis	Possible siderophore-binding protein	0.0042	0.0055	0.026
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0048	0.0066	0.0066
Onchocerca volvulus		0.0247	0.0481	0.9894
Loa Loa (eye worm)	hypothetical protein	0.0079	0.0131	0.0131
Onchocerca volvulus		0.0031	0.0032	0.0137
Brugia malayi	MH2 domain containing protein	0.0122	0.0221	0.0221
Leishmania major	carbonic anhydrase-like protein	0.481	1	1
Echinococcus granulosus	geminin	0.0875	0.1792	0.1792
Trichomonas vaginalis	conserved hypothetical protein	0.1592	0.3288	1
Mycobacterium tuberculosis	Beta-carbonic anhydrase CanB	0.0952	0.1952	0.9299
Trichomonas vaginalis	conserved hypothetical protein	0.1592	0.3288	1
Brugia malayi	Eukaryotic-type carbonic anhydrase family protein	0.1811	0.3744	0.3744
Entamoeba histolytica	hypothetical protein	0.0111	0.0198	0.0463
Echinococcus granulosus	carbonic anhydrase II	0.481	1	1
Loa Loa (eye worm)	MH2 domain-containing protein	0.0122	0.0221	0.0221
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0051	0.0051
Plasmodium falciparum	carbonic anhydrase	0.1811	0.3744	1
Trichomonas vaginalis	set domain proteins, putative	0.0249	0.0486	0.1343
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0051	0.0051
Trypanosoma cruzi	hypothetical protein, conserved	0.0042	0.0055	0.0055
Echinococcus multilocularis	GPCR, family 2	0.0131	0.024	0.024
Mycobacterium tuberculosis	Probable transmembrane carbonic anhydrase (carbonate dehydratase) (carbonic dehydratase)	0.0818	0.1672	0.7966
Schistosoma mansoni	carbonic anhydrase-related	0.1811	0.3744	0.3744
Entamoeba histolytica	hypothetical protein	0.0111	0.0198	0.0463
Plasmodium vivax	hypothetical protein, conserved	0.0041	0.0051	0.3895
Onchocerca volvulus		0.0041	0.0051	0.0555
Toxoplasma gondii	hypothetical protein	0.1811	0.3744	1
Echinococcus granulosus	carbonic anhydrase	0.1811	0.3744	0.3744
Schistosoma mansoni	carbonic anhydrase II (carbonate dehydratase II)	0.481	1	1
Echinococcus granulosus	lamin	0.0028	0.0025	0.0025
Mycobacterium tuberculosis	Conserved protein	0.0041	0.0051	0.0242
Echinococcus multilocularis	histone lysine methyltransferase setb histone lysine methyltransferase eggless	0.0031	0.0032	0.0032
Schistosoma mansoni	intermediate filament proteins	0.0028	0.0025	0.0025
Schistosoma mansoni	hypothetical protein	0.0111	0.0198	0.0198
Brugia malayi	Eukaryotic-type carbonic anhydrase family protein	0.1811	0.3744	0.3744
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0031	0.0032	0.0032
Onchocerca volvulus		0.0041	0.0051	0.0555
Brugia malayi	beta-lactamase	0.0041	0.0051	0.0051
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0414	0.083	0.083
Trypanosoma cruzi	Sulfate transporter N-terminal domain with GLY motif/Sulfate transporter family, putative	0.0034	0.0038	0.0038
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0048	0.0066	0.0066
Brugia malayi	hypothetical protein	0.0051	0.0072	0.0072
Mycobacterium tuberculosis	Possible conserved lipoprotein LpqK	0.0041	0.0051	0.0242
Loa Loa (eye worm)	intermediate filament tail domain-containing protein	0.0028	0.0025	0.0025

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Search by Saint Jude

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 757627