Detailed information for compound 759802

Basic information

Technical information
  • TDR Targets ID: 759802
  • Name: 4-(3-ethoxy-4-hydroxyphenyl)-N-(4-fluoropheny l)-6-methyl-2-sulfanylidene-3,4-dihydro-1H-py rimidine-5-carboxamide
  • MW: 401.455 | Formula: C20H20FN3O3S
  • H donors: 3 H acceptors: 2 LogP: 2.91 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCOc1cc(ccc1O)C1NC(=NC(=C1C(=O)Nc1ccc(cc1)F)C)S
  • InChi: 1S/C20H20FN3O3S/c1-3-27-16-10-12(4-9-15(16)25)18-17(11(2)22-20(28)24-18)19(26)23-14-7-5-13(21)6-8-14/h4-10,18,25H,3H2,1-2H3,(H,23,26)(H2,22,24,28)
  • InChiKey: FQKKJFGCOSKBJX-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 4-(3-ethoxy-4-hydroxy-phenyl)-N-(4-fluorophenyl)-6-methyl-2-thioxo-3,4-dihydro-1H-pyrimidine-5-carboxamide
  • 4-(3-ethoxy-4-hydroxyphenyl)-N-(4-fluorophenyl)-6-methyl-2-thioxo-3,4-dihydro-1H-pyrimidine-5-carboxamide
  • 4-(3-ethoxy-4-hydroxy-phenyl)-N-(4-fluorophenyl)-6-methyl-2-sulfanylidene-3,4-dihydro-1H-pyrimidine-5-carboxamide
  • Oprea1_178384
  • EU-0013972
  • STOCK3S-73846

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0046 0.0415 0.1823
Schistosoma mansoni glucose transport protein 0.0208 0.2274 1
Echinococcus multilocularis solute carrier family 22 0.0029 0.0228 0.0365
Toxoplasma gondii sugar transporter ST2 0.0029 0.0228 0.0327
Mycobacterium ulcerans esterase/lipase LipP 0.0038 0.0332 0.776
Onchocerca volvulus 0.0038 0.0332 1
Toxoplasma gondii calcium-dependent protein kinase CDPK2B 0.0064 0.0623 0.0925
Loa Loa (eye worm) glycyl-tRNA synthetase 0.0012 0.0027 0.0119
Trichomonas vaginalis penicillin-binding protein, putative 0.0038 0.0332 0.1417
Trichomonas vaginalis CAMK family protein kinase 0.0064 0.0622 0.2699
Trypanosoma brucei sugar transporter, putative 0.0029 0.0228 0.303
Trichomonas vaginalis conserved hypothetical protein 0.0208 0.2274 1
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0228 0.0956
Brugia malayi Calcium/calmodulin-dependent protein kinase type II alpha chain 0.0064 0.0622 0.2648
Loa Loa (eye worm) calcium/calmodulin-dependent protein kinase ID 0.0064 0.0622 0.2736
Loa Loa (eye worm) hypothetical protein 0.0062 0.0608 0.2671
Mycobacterium leprae conserved hypothetical protein 0.0038 0.0332 0.5379
Trichomonas vaginalis myo-inositol transporter, putative 0.0029 0.0228 0.0956
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0064 0.0622 0.1081
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0228 0.0956
Trypanosoma cruzi hexose transporter, putative 0.0065 0.0632 0.868
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.0046 0.0425 0.1826
Mycobacterium ulcerans sugar-transport integral membrane protein SugI 0.0029 0.0228 0.5239
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0038 0.0332 0.1194
Brugia malayi beta-lactamase 0.0038 0.0332 0.1357
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0228 0.0956
Loa Loa (eye worm) hypothetical protein 0.0064 0.0622 0.2736
Echinococcus multilocularis glutamyl tRNA synthetase cytoplasmic 0.0062 0.0608 0.1055
Echinococcus granulosus beta LACTamase domain containing family member 0.0038 0.0332 0.0554
Brugia malayi Bifunctional aminoacyl-tRNA synthetase 0.0062 0.0608 0.2583
Trypanosoma brucei cytochrome P450, putative 0.0013 0.0043 0.0442
Loa Loa (eye worm) hypothetical protein 0.0029 0.0228 0.1002
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0019 0.0112 0.1402
Mycobacterium tuberculosis Probable threonyl-tRNA synthetase ThrS (threonine-tRNA synthetase)(ThrRS) (threonine-tRNA ligase) 0.0012 0.0027 0.0058
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0046 0.0415 0.0704
Trichomonas vaginalis conserved hypothetical protein 0.0065 0.0632 0.274
Mycobacterium tuberculosis Probable hydrolase 0.0038 0.0332 0.1194
Leishmania major glucose transporter/membrane transporter D2, putative 0.0065 0.0632 0.868
Trichomonas vaginalis conserved hypothetical protein 0.0029 0.0228 0.0956
Loa Loa (eye worm) hypothetical protein 0.0038 0.0332 0.146
Mycobacterium tuberculosis Probable dicarboxylic acid transport integral membrane protein KgtP (dicarboxylate transporter) 0.0029 0.0228 0.0806
Trypanosoma brucei glucose transporter, putative 0.0065 0.0632 0.868
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0046 0.0415 0.0704
Loa Loa (eye worm) hypothetical protein 0.0038 0.0332 0.146
Echinococcus granulosus lysyl tRNA synthetase 0.0046 0.0425 0.0722
Loa Loa (eye worm) hypothetical protein 0.0062 0.0608 0.2671
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0245 0.2698 1
Trypanosoma cruzi cytochrome P450, putative 0.0013 0.0043 0.0442
Brugia malayi Major Facilitator Superfamily protein 0.0029 0.0228 0.0894
Brugia malayi Major Facilitator Superfamily protein 0.0029 0.0228 0.0894
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0228 0.0956
Loa Loa (eye worm) sugar transporter 0.0029 0.0228 0.1002
Leishmania major threonyl-tRNA synthetase, putative 0.0012 0.0027 0.0218
Trypanosoma cruzi sugar transporter, putative 0.0029 0.0228 0.303
Trichomonas vaginalis conserved hypothetical protein 0.0029 0.0228 0.0956
Schistosoma mansoni glucose transport protein 0.0208 0.2274 1
Trypanosoma brucei THT1 - hexose transporter, putative 0.0065 0.0632 0.868
Loa Loa (eye worm) hypothetical protein 0.0029 0.0228 0.1002
Echinococcus multilocularis solute carrier family 2, facilitated glucose 0.0208 0.2274 0.4083
Mycobacterium ulcerans integral membrane transport protein 0.0029 0.0228 0.5239
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0228 0.0956
Trichomonas vaginalis penicillin-binding protein, putative 0.0038 0.0332 0.1417
Plasmodium vivax CDK-related protein kinase 6, putative 0.0883 1 1
Plasmodium falciparum hexose transporter 0.0208 0.2274 0.2253
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0228 0.0956
Echinococcus multilocularis solute carrier family 22 0.0029 0.0228 0.0365
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0208 0.2274 0.4083
Chlamydia trachomatis proline--tRNA ligase 0.0022 0.0146 0.2978
Mycobacterium leprae Probable lipase LipE 0.0038 0.0332 0.5379
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0019 0.0112 0.1402
Loa Loa (eye worm) hypothetical protein 0.0029 0.0228 0.1002
Leishmania major protein kinase, putative 0.0064 0.0622 0.855
Giardia lamblia Sugar-proton symporter 0.0029 0.0228 0.346
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0228 0.0956
Trichomonas vaginalis D-aminoacylase, putative 0.0038 0.0332 0.1417
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0228 0.0956
Trypanosoma brucei glucose transporter, putative 0.0065 0.0632 0.868
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 1 0.0064 0.0622 0.1081
Mycobacterium tuberculosis Probable conserved integral membrane transport protein 0.0029 0.0228 0.0806
Schistosoma mansoni protein kinase 0.0064 0.0622 0.2648
Trichomonas vaginalis threonyl-tRNA synthetase, putative 0.0012 0.0027 0.0069
Echinococcus granulosus neuropeptide s receptor 0.0493 0.5531 1
Mycobacterium ulcerans fusion protein of transposase for IS2606 and sialic acid-transport integral membrane protein NanT 0.0029 0.0228 0.5239
Toxoplasma gondii glycyl-tRNA synthetase 0.0012 0.0027 0.0024
Toxoplasma gondii lysine-tRNA ligase 0.0046 0.0425 0.0625
Trypanosoma cruzi threonyl-tRNA synthetase, putative 0.0012 0.0027 0.0218
Loa Loa (eye worm) hypothetical protein 0.0029 0.0228 0.1002
Trypanosoma cruzi threonyl-tRNA synthetase, putative 0.0012 0.0027 0.0218
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0019 0.0112 0.0491
Echinococcus multilocularis synaptic vesicle 2 protein 0.0029 0.0228 0.0365
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0228 0.0956
Treponema pallidum prolyl-tRNA synthetase 0.0022 0.0146 1
Brugia malayi beta-lactamase family protein 0.0038 0.0332 0.1357
Loa Loa (eye worm) hypothetical protein 0.0038 0.0332 0.146
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0064 0.0622 0.1081
Mycobacterium ulcerans sugar transporter 0.0029 0.0228 0.5239
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0228 0.0956
Brugia malayi hypothetical protein 0.0029 0.0228 0.0894
Toxoplasma gondii exonuclease III APE 0.0019 0.0112 0.0152
Brugia malayi Cytochrome P450 family protein 0.0013 0.0043 0.0071
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.0041 0.0359 0.1536
Trypanosoma cruzi glucose transporter, putative 0.0029 0.0228 0.303
Mycobacterium ulcerans threonyl-tRNA synthetase 0.0012 0.0027 0.0377
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0208 0.2274 0.4083
Trypanosoma brucei bifunctional aminoacyl-tRNA synthetase, putative 0.0073 0.0726 1
Trichomonas vaginalis sugar transporter, putative 0.0065 0.0632 0.274
Plasmodium vivax calcium-dependent protein kinase, putative 0.0064 0.0623 0.0597
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0228 0.0956
Echinococcus multilocularis neuropeptide s receptor 0.0493 0.5531 1
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0019 0.0112 0.2425
Mycobacterium tuberculosis Probable esterase LipL 0.0038 0.0332 0.1194
Plasmodium falciparum calcium-dependent protein kinase 4 0.0064 0.0623 0.0597
Echinococcus granulosus solute carrier family 22 0.0029 0.0228 0.0365
Leishmania major lysyl-tRNA synthetase, putative 0.0046 0.0425 0.5783
Schistosoma mansoni hypothetical protein 0.0182 0.1972 0.8653
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0228 0.0956
Brugia malayi Sugar transporter family protein 0.0029 0.0228 0.0894
Toxoplasma gondii threonyl-tRNA synthetase family protein 0.0012 0.0027 0.0024
Schistosoma mansoni serine/threonine protein kinase 0.0064 0.0622 0.2648
Echinococcus multilocularis beta LACTamase domain containing family member 0.0038 0.0332 0.0554
Loa Loa (eye worm) beta-lactamase 0.0038 0.0332 0.146
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0228 0.0956
Trypanosoma cruzi lysyl-tRNA synthetase, putative 0.0046 0.0425 0.5783
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0073 0.0726 1
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0228 0.0956
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0073 0.0726 1
Trypanosoma brucei glucose transporter, putative 0.0065 0.0632 0.868
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0019 0.0112 0.0154
Schistosoma mansoni lysyl-tRNA synthetase 0.0046 0.0425 0.1769
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.0415 0.1724
Toxoplasma gondii cell-cycle-associated protein kinase MAPK, putative 0.0336 0.3741 0.5643
Mycobacterium ulcerans lipase LipD 0.0038 0.0332 0.776
Schistosoma mansoni glucose transport protein 0.0208 0.2274 1
Leishmania major hypothetical protein, conserved 0.0038 0.0332 0.4488
Mycobacterium tuberculosis Conserved protein 0.0038 0.0332 0.1194
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0019 0.0112 0.1402
Toxoplasma gondii sugar transporter ST3 0.0029 0.0228 0.0327
Toxoplasma gondii ABC1 family protein 0.0038 0.0332 0.0485
Plasmodium falciparum calcium-dependent protein kinase 5 0.0064 0.0623 0.0597
Echinococcus granulosus neuropeptide receptor A26 0.0493 0.5531 1
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0064 0.0622 0.1081
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0228 0.0956
Schistosoma mansoni hypothetical protein 0.0182 0.1972 0.8653
Echinococcus multilocularis Sugar transporter ERD6 protein 0.0029 0.0228 0.0365
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0228 0.0956
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0228 0.0956
Brugia malayi Sugar transporter family protein 0.0208 0.2274 1
Chlamydia trachomatis lysine--tRNA ligase 0.0046 0.0425 1
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0046 0.0415 0.0704
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0228 0.0956
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0228 0.0956
Trichomonas vaginalis esterase, putative 0.0038 0.0332 0.1417
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.0415 0.1724
Plasmodium vivax calcium-dependent protein kinase 4, putative 0.0064 0.0623 0.0597
Loa Loa (eye worm) cytochrome P450 family protein 0.0013 0.0043 0.019
Loa Loa (eye worm) hypothetical protein 0.0038 0.0332 0.146
Toxoplasma gondii transporter, major facilitator family protein 0.0029 0.0228 0.0327
Trypanosoma cruzi cytochrome P450, putative 0.0013 0.0043 0.0442
Mycobacterium ulcerans prolyl-tRNA synthetase 0.0022 0.0146 0.3243
Leishmania major cytochrome p450-like protein 0.0013 0.0043 0.0442
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0064 0.0622 0.1081
Plasmodium falciparum protein kinase 7 0.0588 0.6621 0.6612
Loa Loa (eye worm) CYP4Cod1 0.0013 0.0043 0.019
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0038 0.0332 0.1357
Schistosoma mansoni nuclear transcription factor X-box binding 1 (nfx1) 0.0029 0.0228 0.0894
Plasmodium vivax lysine--tRNA ligase, putative 0.0046 0.0425 0.0399
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0073 0.0726 1
Trypanosoma brucei lysyl-tRNA synthetase, putative 0.0046 0.0425 0.5783
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.0415 0.1724
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0112 0.0443
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0064 0.0622 0.1081
Loa Loa (eye worm) hypothetical protein 0.0029 0.0228 0.1002
Schistosoma mansoni sugar transporter 0.0029 0.0228 0.0894
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0228 0.0956
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0046 0.0425 1
Loa Loa (eye worm) bifunctional aminoacyl-tRNA synthetase 0.0026 0.0186 0.082
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0062 0.0608 0.2583
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0046 0.0425 1
Trichomonas vaginalis glucose transporter, putative 0.0029 0.0228 0.0956
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0062 0.0608 0.2583
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0038 0.0332 0.776
Loa Loa (eye worm) CAMK/CAMK2 protein kinase 0.0064 0.0622 0.2736
Loa Loa (eye worm) hypothetical protein 0.0029 0.0228 0.1002
Plasmodium falciparum lysine--tRNA ligase 0.0046 0.0425 0.0399
Mycobacterium leprae Probable lysyl-tRNA synthase LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase) 0.0039 0.0345 0.5587
Mycobacterium ulcerans hypothetical protein 0.0038 0.0332 0.776
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0038 0.0332 0.1357
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0228 0.0956
Schistosoma mansoni protein kinase 0.0064 0.0622 0.2648
Giardia lamblia Hexose transporter 0.0029 0.0228 0.346
Toxoplasma gondii calcium-dependent protein kinase CDPK2A 0.0064 0.0623 0.0925
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0208 0.2274 0.4083
Plasmodium falciparum calcium-dependent protein kinase 3 0.0064 0.0623 0.0597
Loa Loa (eye worm) hypothetical protein 0.0029 0.0228 0.1002
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0038 0.0332 0.1194
Trypanosoma brucei glucose transporter 1E 0.0065 0.0632 0.868
Trypanosoma brucei hypothetical protein, conserved 0.0038 0.0332 0.4488
Echinococcus granulosus solute carrier family 22 0.0029 0.0228 0.0365
Schistosoma mansoni ap endonuclease 0.0019 0.0112 0.0376
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0019 0.0112 0.1402
Mycobacterium tuberculosis Lysyl-tRNA synthetase 1 LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase) 0.0039 0.0345 0.124
Leishmania major myo-inositol/proton symporter (MIT) 0.0029 0.0228 0.303
Leishmania major glucose transporter, lmgt2 0.0065 0.0632 0.868
Brugia malayi hypothetical protein 0.0029 0.0228 0.0894
Trypanosoma brucei calcium/calmodulin-dependent protein kinase, putative 0.0064 0.0622 0.855
Mycobacterium tuberculosis Probable lipase LipE 0.0038 0.0332 0.1194
Echinococcus multilocularis solute carrier family 22 0.0029 0.0228 0.0365
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0228 0.0956
Treponema pallidum exodeoxyribonuclease (exoA) 0.0019 0.0112 0.7147
Loa Loa (eye worm) hypothetical protein 0.0046 0.0425 0.1867
Brugia malayi hypothetical protein 0.0029 0.0228 0.0894
Entamoeba histolytica hypothetical protein 0.0046 0.0425 0.6679
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0228 0.0956
Echinococcus granulosus General substrate transporter 0.0179 0.194 0.3475
Loa Loa (eye worm) hypothetical protein 0.0029 0.0228 0.1002
Brugia malayi Major Facilitator Superfamily protein 0.0029 0.0228 0.0894
Echinococcus multilocularis solute carrier family 22 0.0029 0.0228 0.0365
Wolbachia endosymbiont of Brugia malayi major facilitator superfamily permease 0.0029 0.0228 1
Loa Loa (eye worm) hypothetical protein 0.0051 0.0474 0.2082
Plasmodium vivax proline--tRNA ligase, putative 0.0073 0.0726 0.0701
Trypanosoma cruzi hexose transporter, putative 0.0035 0.0297 0.3994
Plasmodium vivax hypothetical protein, conserved 0.0038 0.0332 0.0306
Schistosoma mansoni ap endonuclease 0.0019 0.0112 0.0376
Schistosoma mansoni glucose transporter 0.0029 0.0228 0.0894
Trypanosoma brucei THT1 - hexose transporter, putative 0.0065 0.0632 0.868
Brugia malayi beta-lactamase family protein 0.0038 0.0332 0.1357
Trypanosoma cruzi hexose transporter 0.0065 0.0632 0.868
Trichomonas vaginalis prolyl-tRNA synthetase, putative 0.0062 0.0608 0.2634
Mycobacterium tuberculosis Lysyl-tRNA synthetase 2 LysX 0.0039 0.0345 0.124
Mycobacterium leprae Possible lysyl-tRNA synthetase 2 LysX 0.0046 0.0425 0.6932
Toxoplasma gondii calcium-dependent protein kinase CDPK3 0.0064 0.0623 0.0925
Loa Loa (eye worm) hypothetical protein 0.0029 0.0228 0.1002
Trichomonas vaginalis D-aminoacylase, putative 0.0038 0.0332 0.1417
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0112 0.0443
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0038 0.0332 0.146
Trypanosoma brucei myo-inositol/proton symporter (MIT) 0.0029 0.0228 0.303
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0228 0.0956
Entamoeba histolytica prolyl-tRNA synthetase, putative 0.0062 0.0608 0.9752
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0228 0.0956
Trypanosoma brucei glucose transporter, putative 0.0065 0.0632 0.868
Trichomonas vaginalis D-aminoacylase, putative 0.0038 0.0332 0.1417
Trichomonas vaginalis sugar transporter, putative 0.0065 0.0632 0.274
Mycobacterium ulcerans glycyl-tRNA synthetase 0.0012 0.0027 0.0377
Plasmodium vivax hexose transporter 0.0208 0.2274 0.2253
Plasmodium falciparum proline--tRNA ligase 0.0073 0.0726 0.0701
Trichomonas vaginalis conserved hypothetical protein 0.0029 0.0228 0.0956
Loa Loa (eye worm) hypothetical protein 0.0029 0.0228 0.1002
Plasmodium falciparum major facilitator superfamily domain-containing protein, putative 0.0029 0.0228 0.0201
Brugia malayi major facilitator superfamily protein 0.0029 0.0228 0.0894
Trypanosoma cruzi hypothetical protein, conserved 0.0038 0.0332 0.4488
Loa Loa (eye worm) hypothetical protein 0.0029 0.0228 0.1002
Trypanosoma brucei glucose transporter, putative 0.0065 0.0632 0.868
Trypanosoma brucei glucose transporter 2A 0.0065 0.0632 0.868
Echinococcus granulosus synaptic vesicle 2 protein 0.0029 0.0228 0.0365
Echinococcus granulosus Sugar transporter ERD6 protein 0.0029 0.0228 0.0365
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0038 0.0332 0.1357
Toxoplasma gondii sugar transporter ST1 0.0029 0.0228 0.0327
Trypanosoma cruzi hexose transporter, putative 0.0029 0.0228 0.303
Schistosoma mansoni lysyl-tRNA synthetase 0.0046 0.0425 0.1769
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0228 0.0956
Schistosoma mansoni sugar transporter 0.0029 0.0228 0.0894
Mycobacterium tuberculosis Probable lipase LipD 0.0038 0.0332 0.1194
Echinococcus granulosus solute carrier family 22 0.0029 0.0228 0.0365
Loa Loa (eye worm) hypothetical protein 0.0012 0.0027 0.0119
Plasmodium falciparum calcium-dependent protein kinase 2 0.0064 0.0623 0.0597
Trypanosoma brucei threonyl-tRNA synthetase, putative 0.0012 0.0027 0.0218
Echinococcus multilocularis neuropeptide receptor A26 0.0493 0.5531 1
Trichomonas vaginalis glucose transporter, putative 0.0065 0.0632 0.274
Loa Loa (eye worm) hypothetical protein 0.0038 0.0332 0.146
Leishmania major glucose transporter, lmgt3 0.0065 0.0632 0.868
Echinococcus granulosus calcium dependent protein kinase 0.006 0.0577 0.0999
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0019 0.0112 0.0373
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0228 0.0956
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0228 0.0956
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0228 0.0956
Toxoplasma gondii facilitative glucose transporter GT1 0.0208 0.2274 0.3424
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0112 0.0085
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0208 0.2274 0.4083
Loa Loa (eye worm) hypothetical protein 0.0029 0.0228 0.1002
Brugia malayi Sugar transporter family protein 0.0029 0.0228 0.0894
Onchocerca volvulus 0.0038 0.0332 1
Brugia malayi exodeoxyribonuclease III family protein 0.0019 0.0112 0.0376
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0046 0.0415 0.0704
Echinococcus granulosus glutamyl tRNA synthetase cytoplasmic 0.0062 0.0608 0.1055
Loa Loa (eye worm) major facilitator superfamily transporter 0.0029 0.0228 0.1002
Loa Loa (eye worm) hypothetical protein 0.0038 0.0332 0.146
Brugia malayi lysyl-tRNA synthetase 0.0046 0.0425 0.1769
Loa Loa (eye worm) threonyl-tRNA synthetase 0.0012 0.0027 0.0119
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0228 0.0956
Echinococcus granulosus geminin 0.0182 0.1972 0.3533
Brugia malayi Cytochrome P450 family protein 0.0013 0.0043 0.0071
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0228 0.0956
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0064 0.0622 0.1081
Loa Loa (eye worm) cytochrome P450 family protein 0.0013 0.0043 0.019
Entamoeba histolytica protein kinase, putative 0.0064 0.0622 1
Trypanosoma cruzi hexose transporter, putative 0.0065 0.0632 0.868
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0019 0.0112 0.0154
Schistosoma mansoni hypothetical protein 0.0208 0.2274 1
Brugia malayi Cam kinase protein 1 0.0064 0.0622 0.2648
Plasmodium vivax calcium-dependent protein kinase 3, putative 0.0064 0.0623 0.0597
Giardia lamblia Prolyl-tRNA synthetase 0.0062 0.0608 1
Trichomonas vaginalis conserved hypothetical protein 0.0029 0.0228 0.0956
Trypanosoma brucei glucose transporter, putative 0.0065 0.0632 0.868
Echinococcus multilocularis geminin 0.0182 0.1972 0.3533
Mycobacterium leprae Probable prolyl tRNA synthetase ProS 0.0062 0.0608 1
Entamoeba histolytica protein kinase, putative 0.0064 0.0622 1
Plasmodium falciparum calcium-dependent protein kinase 1 0.0064 0.0623 0.0597
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0228 0.0956
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0073 0.0726 1
Echinococcus granulosus solute carrier family 22 0.0029 0.0228 0.0365
Onchocerca volvulus 0.0038 0.0332 1
Trichomonas vaginalis conserved hypothetical protein 0.0029 0.0228 0.0956
Trichomonas vaginalis sugar transporter, putative 0.0065 0.0632 0.274
Toxoplasma gondii prolyl-tRNA synthetase (ProRS) 0.0073 0.0726 0.1081
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0208 0.2274 0.4083
Plasmodium falciparum mitogen-activated protein kinase 2 0.0336 0.3741 0.3724
Schistosoma mansoni sugar transporter 0.0029 0.0228 0.0894
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0013 0.0043 0.0765
Trypanosoma brucei glycyl-tRNA synthetase, putative 0.0012 0.0027 0.0218
Trypanosoma brucei glucose transporter, putative 0.0065 0.0632 0.868
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0019 0.0112 0.1421
Trichomonas vaginalis conserved hypothetical protein 0.0065 0.0632 0.274
Plasmodium vivax mitogen-activated protein kinase 2, putative 0.0336 0.3741 0.3724
Toxoplasma gondii protein kinase, putative 0.0588 0.6621 1
Trichomonas vaginalis glucose transporter, putative 0.0065 0.0632 0.274
Trichomonas vaginalis sugar transport protein, putative 0.0029 0.0228 0.0956
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0019 0.0112 0.1458
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0228 0.0956
Brugia malayi bifunctional aminoacyl-tRNA synthetase 0.0062 0.0608 0.2583
Loa Loa (eye worm) sugar transporter 0.0208 0.2274 1
Leishmania major glucose transporter, lmgt1 0.0065 0.0632 0.868
Mycobacterium leprae Probable threonyl-tRNA synthetase ThrS (threonine-tRNA synthetase) (ThrRS) (Threonine-tRNA ligase) 0.0012 0.0027 0.0262
Schistosoma mansoni sugar transporter 0.0029 0.0228 0.0894
Loa Loa (eye worm) hypothetical protein 0.0029 0.0228 0.1002
Brugia malayi major facilitator superfamily protein 0.0029 0.0228 0.0894
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0046 0.0415 0.1724
Echinococcus multilocularis General substrate transporter 0.0179 0.194 0.3475
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0019 0.0112 0.4212
Plasmodium vivax sugar transporter, putative 0.0029 0.0228 0.0201
Mycobacterium tuberculosis Conserved protein 0.0038 0.0332 0.1194
Giardia lamblia Lysyl-tRNA synthetase 0.0046 0.0425 0.6849
Trypanosoma brucei glucose transporter, putative 0.0065 0.0632 0.868
Mycobacterium ulcerans beta-lactamase 0.0038 0.0332 0.776
Loa Loa (eye worm) major facilitator superfamily transporter 0.0029 0.0228 0.1002
Echinococcus multilocularis lysyl tRNA synthetase 0.0046 0.0425 0.0722
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0208 0.2274 0.4083
Trypanosoma cruzi hypothetical protein, conserved 0.0038 0.0332 0.4488
Leishmania major hypothetical protein, conserved 0.0029 0.0228 0.303
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0064 0.0622 0.1081
Trypanosoma cruzi hexose transporter, putative 0.0065 0.0632 0.868
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0112 0.0085
Schistosoma mansoni protein kinase 0.0064 0.0622 0.2648
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0208 0.2274 0.4083
Trypanosoma brucei THT1 - hexose transporter, putative 0.0065 0.0632 0.868
Echinococcus multilocularis calcium dependent protein kinase 0.006 0.0577 0.0999
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0038 0.0332 0.1194
Loa Loa (eye worm) hypothetical protein 0.0029 0.0228 0.1002
Loa Loa (eye worm) hypothetical protein 0.0029 0.0228 0.1002
Mycobacterium tuberculosis Conserved protein 0.0038 0.0332 0.1194
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0228 0.0956
Plasmodium vivax calcium-dependent protein kinase 1, putative 0.0064 0.0623 0.0597
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0228 0.0956

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.