TDR Targets

Basic information

Technical information

TDR Targets ID: 763593
Name: 2-(4,5-dimethyl-1,3-thiazol-2-yl)-1-phenyl-1H -chromeno[2,3-c]pyrrole-3,9-dione
MW: 388.439 | Formula: C22H16N2O3S
H donors: 0 H acceptors: 3 LogP: 4.21 Rotable bonds: 2
Rule of 5 violations (Lipinski): 1
SMILES: Cc1nc(sc1C)N1C(=O)c2c(C1c1ccccc1)c(=O)c1c(o2)cccc1
InChi: 1S/C22H16N2O3S/c1-12-13(2)28-22(23-12)24-18(14-8-4-3-5-9-14)17-19(25)15-10-6-7-11-16(15)27-20(17)21(24)26/h3-11,18H,1-2H3
InChiKey: VWQUGTUGRHFASZ-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

2-(4,5-dimethylthiazol-2-yl)-1-phenyl-1H-chromeno[2,3-c]pyrrole-3,9-dione
2-(4,5-dimethyl-2-thiazolyl)-1-phenyl-1H-chromeno[2,3-c]pyrrole-3,9-dione
2-(4,5-dimethylthiazol-2-yl)-1-phenyl-1H-chromeno[2,3-c]pyrrole-3,9-quinone
STOCK3S-90931

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Mycobacterium tuberculosis	Conserved protein	0.0084	0.053	0.1302
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0084	0.053	0.2311
Mycobacterium tuberculosis	Lysyl-tRNA synthetase 2 LysX	0.0062	0.037	0.0878
Trypanosoma cruzi	Aminoacyl-tRNA editing domain containing protein, putative	0.0016	0.0038	0.0504
Loa Loa (eye worm)	hypothetical protein	0.0046	0.0254	0.1106
Trichomonas vaginalis	conserved hypothetical protein	0.0046	0.0254	0.1106
Echinococcus granulosus	geminin	0.017	0.1149	0.3489
Trichomonas vaginalis	CAMK family protein kinase	0.01	0.0647	0.2819
Mycobacterium ulcerans	threonyl-tRNA synthetase	0.0018	0.0053	0.1006
Mycobacterium ulcerans	prolyl-tRNA synthetase	0.0035	0.0171	0.3233
Trichomonas vaginalis	conserved hypothetical protein	0.0016	0.0038	0.0165
Loa Loa (eye worm)	hypothetical protein	0.0098	0.0632	0.2755
Echinococcus granulosus	calcium dependent protein kinase	0.0094	0.0602	0.1828
Trichomonas vaginalis	sugar transporter, putative	0.0046	0.0254	0.1106
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0158	0.1066	0.4645
Loa Loa (eye worm)	hypothetical protein	0.0084	0.053	0.2311
Trypanosoma brucei	glucose transporter, putative	0.0102	0.0656	0.8747
Echinococcus multilocularis	geminin	0.017	0.1149	0.177
Loa Loa (eye worm)	beta-lactamase	0.0084	0.053	0.2311
Leishmania major	threonyl-tRNA synthetase, putative	0.0018	0.0053	0.0711
Echinococcus granulosus	solute carrier family 2 facilitated glucose	0.0328	0.2295	0.6966
Trichomonas vaginalis	sugar transporter, putative	0.0046	0.0254	0.1106
Trypanosoma brucei	glycyl-tRNA synthetase, putative	0.0018	0.0053	0.0711
Echinococcus multilocularis	solute carrier family 22	0.0046	0.0254	0.0391
Leishmania major	glucose transporter, lmgt3	0.0102	0.0656	0.8747
Trichomonas vaginalis	sugar transporter, putative	0.0046	0.0254	0.1106
Brugia malayi	probable proline-trna synthetase - fission yeast, putative	0.0018	0.0053	0.0192
Echinococcus granulosus	solute carrier family 22	0.0046	0.0254	0.077
Trypanosoma cruzi	hexose transporter	0.0102	0.0656	0.8747
Trypanosoma cruzi	cytochrome P450, putative	0.0012	0.001	0.0127
Mycobacterium tuberculosis	Probable esterase LipL	0.0084	0.053	0.1302
Loa Loa (eye worm)	hypothetical protein	0.0084	0.053	0.2311
Loa Loa (eye worm)	hypothetical protein	0.0046	0.0254	0.1106
Mycobacterium leprae	Probable lysyl-tRNA synthase LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase)	0.0062	0.037	0.5587
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0158	0.1066	0.4645
Plasmodium vivax	proline--tRNA ligase, putative	0.0115	0.075	0.075
Plasmodium vivax	calcium-dependent protein kinase 4, putative	0.01	0.0647	0.0647
Echinococcus granulosus	glycyl tRNA synthetase	0.0018	0.0053	0.0162
Echinococcus multilocularis	atpase aaa+ type core atpase aaa type core	0.0906	0.6491	1
Echinococcus granulosus	Threonyl tRNA synthetase C	0.0018	0.0053	0.0162
Trichomonas vaginalis	sugar transporter, putative	0.0046	0.0254	0.1106
Plasmodium vivax	threonine--tRNA ligase, putative	0.0018	0.0053	0.0053
Leishmania major	glucose transporter, lmgt1	0.0102	0.0656	0.8747
Trypanosoma brucei	hypothetical protein, conserved	0.0084	0.053	0.7067
Trichomonas vaginalis	conserved hypothetical protein	0.0046	0.0254	0.1106
Loa Loa (eye worm)	sugar transporter	0.0046	0.0254	0.1106
Trichomonas vaginalis	esterase, putative	0.0084	0.053	0.2311
Schistosoma mansoni	tar DNA-binding protein	0.0074	0.0457	0.1991
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0158	0.1066	0.4623
Toxoplasma gondii	protein kinase, putative	0.0925	0.663	1
Mycobacterium leprae	Probable threonyl-tRNA synthetase ThrS (threonine-tRNA synthetase) (ThrRS) (Threonine-tRNA ligase)	0.0018	0.0053	0.0262
Plasmodium vivax	glycine--tRNA ligase, putative	0.0018	0.0053	0.0053
Plasmodium vivax	calcium-dependent protein kinase, putative	0.01	0.0647	0.0647
Schistosoma mansoni	tar DNA-binding protein	0.0074	0.0457	0.1991
Leishmania major	hypothetical protein, conserved	0.0046	0.0254	0.3381
Trichomonas vaginalis	sugar transporter, putative	0.0046	0.0254	0.1106
Trypanosoma cruzi	hexose transporter, putative	0.0102	0.0656	0.8747
Mycobacterium tuberculosis	Possible penicillin-binding protein	0.0538	0.382	1
Echinococcus multilocularis	solute carrier family 2 facilitated glucose	0.0328	0.2295	0.3535
Echinococcus granulosus	calcium:calmodulin dependent protein kinase type	0.01	0.0647	0.1964
Loa Loa (eye worm)	RNA binding protein	0.0074	0.0457	0.1991
Echinococcus granulosus	neuropeptide receptor A26	0.0465	0.3294	1
Echinococcus multilocularis	solute carrier family 22	0.0046	0.0254	0.0391
Mycobacterium tuberculosis	Possible conserved lipoprotein LpqK	0.0084	0.053	0.1302
Mycobacterium tuberculosis	Conserved protein	0.0084	0.053	0.1302
Echinococcus multilocularis	solute carrier family 2 facilitated glucose	0.0328	0.2295	0.3535
Trichomonas vaginalis	sugar transporter, putative	0.0046	0.0254	0.1106
Trichomonas vaginalis	prolyl-tRNA synthetase, putative	0.0098	0.0632	0.2755
Schistosoma mansoni	lysyl-tRNA synthetase	0.0073	0.045	0.196
Loa Loa (eye worm)	hypothetical protein	0.0084	0.053	0.2311
Echinococcus multilocularis	beta LACTamase domain containing family member	0.0084	0.053	0.0817
Mycobacterium ulcerans	cytochrome P450 185A4 Cyp185A4	0.0012	0.001	0.0179
Plasmodium vivax	sugar transporter, putative	0.0046	0.0254	0.0254
Loa Loa (eye worm)	hypothetical protein	0.0046	0.0254	0.1106
Trypanosoma cruzi	Aminoacyl-tRNA editing domain containing protein, putative	0.0016	0.0038	0.0504
Trichomonas vaginalis	penicillin-binding protein, putative	0.0084	0.053	0.2311
Trypanosoma brucei	Aminoacyl-tRNA editing domain containing protein, putative	0.0016	0.0038	0.0504
Plasmodium vivax	lysine--tRNA ligase, putative	0.0073	0.045	0.045
Echinococcus granulosus	solute carrier family 2 facilitated glucose	0.0328	0.2295	0.6966
Trichomonas vaginalis	conserved hypothetical protein	0.0016	0.0038	0.0165
Trichomonas vaginalis	sugar transporter, putative	0.0046	0.0254	0.1106
Brugia malayi	Cam kinase protein 1	0.01	0.0647	0.279
Echinococcus multilocularis	calcium:calmodulin dependent protein kinase type	0.01	0.0647	0.0997
Mycobacterium leprae	Probable prolyl tRNA synthetase ProS	0.0098	0.0632	1
Trichomonas vaginalis	glucose transporter, putative	0.0102	0.0656	0.286
Chlamydia trachomatis	lysine--tRNA ligase	0.0073	0.045	1
Plasmodium vivax	hypothetical protein, conserved	0.0084	0.053	0.053
Loa Loa (eye worm)	hypothetical protein	0.0046	0.0254	0.1106
Trichomonas vaginalis	sugar transporter, putative	0.0046	0.0254	0.1106
Trypanosoma brucei	bifunctional aminoacyl-tRNA synthetase, putative	0.0115	0.075	1
Onchocerca volvulus		0.0084	0.053	1
Toxoplasma gondii	prolyl-tRNA synthetase (ProRS)	0.0115	0.075	0.1132
Echinococcus granulosus	beta LACTamase domain containing family member	0.0084	0.053	0.161
Loa Loa (eye worm)	TAR-binding protein	0.0074	0.0457	0.1991
Trypanosoma brucei	glucose transporter, putative	0.0102	0.0656	0.8747
Loa Loa (eye worm)	cytochrome P450 family protein	0.0012	0.001	0.0041
Mycobacterium ulcerans	lysyl-tRNA synthetase	0.0073	0.045	0.8484
Giardia lamblia	Sugar-proton symporter	0.0046	0.0254	0.346
Trichomonas vaginalis	sugar transporter, putative	0.0046	0.0254	0.1106
Toxoplasma gondii	glycyl-tRNA synthetase	0.0018	0.0053	0.008
Trichomonas vaginalis	sugar transporter, putative	0.0046	0.0254	0.1106
Mycobacterium ulcerans	lysyl-tRNA synthetase	0.0073	0.045	0.8484
Plasmodium falciparum	calcium-dependent protein kinase 4	0.01	0.0647	0.0647
Trichomonas vaginalis	D-aminoacylase, putative	0.0084	0.053	0.2311
Trypanosoma cruzi	hypothetical protein, conserved	0.0016	0.0038	0.0504
Wolbachia endosymbiont of Brugia malayi	prolyl-tRNA synthetase	0.0018	0.0053	0.2103
Mycobacterium ulcerans	hypothetical protein	0.0084	0.053	1
Schistosoma mansoni	tar DNA-binding protein	0.0074	0.0457	0.1991
Toxoplasma gondii	calcium-dependent protein kinase CDPK2B	0.01	0.0647	0.0976
Trichomonas vaginalis	sugar transporter, putative	0.0046	0.0254	0.1106
Mycobacterium ulcerans	integral membrane transport protein	0.0046	0.0254	0.4784
Trichomonas vaginalis	sugar transporter, putative	0.0046	0.0254	0.1106
Brugia malayi	hypothetical protein	0.0046	0.0254	0.1069
Schistosoma mansoni	glucose transport protein	0.0328	0.2295	1
Entamoeba histolytica	hypothetical protein	0.0073	0.045	0.6953
Echinococcus multilocularis	calcium:calmodulin dependent protein kinase type	0.01	0.0647	0.0997
Brugia malayi	glycyl-tRNA synthetase	0.0018	0.0053	0.0192
Schistosoma mansoni	glucose transport protein	0.0328	0.2295	1
Brugia malayi	beta-lactamase	0.0084	0.053	0.2279
Echinococcus granulosus	solute carrier family 22	0.0046	0.0254	0.077
Entamoeba histolytica	protein kinase, putative	0.01	0.0647	1
Plasmodium falciparum	calcium-dependent protein kinase 3	0.01	0.0647	0.0647
Echinococcus multilocularis	calcium:calmodulin dependent protein kinase type	0.01	0.0647	0.0997
Schistosoma mansoni	serine/threonine protein kinase	0.01	0.0647	0.2819
Trichomonas vaginalis	sugar transporter, putative	0.0046	0.0254	0.1106
Loa Loa (eye worm)	hypothetical protein	0.008	0.0499	0.2173
Mycobacterium tuberculosis	Probable lipase LipD	0.0084	0.053	0.1302
Trichomonas vaginalis	sugar transporter, putative	0.0046	0.0254	0.1106
Trypanosoma brucei	glucose transporter, putative	0.0102	0.0656	0.8747
Trichomonas vaginalis	sugar transport protein, putative	0.0046	0.0254	0.1106
Treponema pallidum	threonyl-tRNA synthetase	0.0018	0.0053	0.3113
Trypanosoma brucei	glucose transporter 2A	0.0102	0.0656	0.8747
Entamoeba histolytica	protein kinase, putative	0.01	0.0647	1
Echinococcus multilocularis	solute carrier family 22	0.0046	0.0254	0.0391
Trypanosoma brucei	glucose transporter, putative	0.0102	0.0656	0.8747
Loa Loa (eye worm)	CYP4Cod1	0.0012	0.001	0.0041
Loa Loa (eye worm)	hypothetical protein	0.0046	0.0254	0.1106
Trichomonas vaginalis	sugar transporter, putative	0.0046	0.0254	0.1106
Echinococcus multilocularis	tar DNA binding protein	0.0074	0.0457	0.0704
Trichomonas vaginalis	glucose transporter, putative	0.0046	0.0254	0.1106
Echinococcus granulosus	solute carrier family 2 facilitated glucose	0.0328	0.2295	0.6966
Echinococcus multilocularis	Sugar transporter ERD6 protein	0.0046	0.0254	0.0391
Schistosoma mansoni	sugar transporter	0.0046	0.0254	0.1106
Trypanosoma brucei	threonyl-tRNA synthetase, putative	0.0018	0.0053	0.0711
Trypanosoma cruzi	threonyl-tRNA synthetase, putative	0.0018	0.0053	0.0711
Trichomonas vaginalis	sugar transporter, putative	0.0046	0.0254	0.1106
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0053	0.0233
Mycobacterium tuberculosis	Probable conserved lipoprotein	0.0084	0.053	0.1302
Toxoplasma gondii	ABC1 family protein	0.0084	0.053	0.08
Echinococcus granulosus	Sugar transporter ERD6 protein	0.0046	0.0254	0.077
Trichomonas vaginalis	lysyl-tRNA synthetase, putative	0.0073	0.045	0.196
Mycobacterium tuberculosis	Probable threonyl-tRNA synthetase ThrS (threonine-tRNA synthetase)(ThrRS) (threonine-tRNA ligase)	0.0018	0.0053	0.0041
Plasmodium vivax	mitogen-activated protein kinase 2, putative	0.0529	0.3758	0.3758
Loa Loa (eye worm)	major facilitator superfamily transporter	0.0046	0.0254	0.1106
Trichomonas vaginalis	D-aminoacylase, putative	0.0084	0.053	0.2311
Plasmodium falciparum	threonine--tRNA ligase	0.0018	0.0053	0.0053
Trichomonas vaginalis	conserved hypothetical protein	0.0016	0.0038	0.0165
Echinococcus multilocularis	neuropeptide receptor A26	0.0465	0.3294	0.5075
Loa Loa (eye worm)	hypothetical protein	0.0046	0.0254	0.1106
Wolbachia endosymbiont of Brugia malayi	threonyl-tRNA synthetase	0.0018	0.0053	0.2103
Brugia malayi	major facilitator superfamily protein	0.0046	0.0254	0.1069
Toxoplasma gondii	lysine-tRNA ligase	0.0073	0.045	0.0679
Schistosoma mansoni	sugar transporter	0.0046	0.0254	0.1106
Trichomonas vaginalis	sugar transporter, putative	0.0046	0.0254	0.1106
Schistosoma mansoni	protein kinase	0.01	0.0647	0.2819
Echinococcus multilocularis	calcium dependent protein kinase	0.0094	0.0602	0.0927
Toxoplasma gondii	transporter, major facilitator family protein	0.0046	0.0254	0.0383
Loa Loa (eye worm)	hypothetical protein	0.0046	0.0254	0.1106
Echinococcus granulosus	neuropeptide s receptor	0.0465	0.3294	1
Schistosoma mansoni	sugar transporter	0.0046	0.0254	0.1106
Loa Loa (eye worm)	hypothetical protein	0.0046	0.0254	0.1106
Brugia malayi	lysyl-tRNA synthetase	0.0073	0.045	0.1927
Toxoplasma gondii	facilitative glucose transporter GT1	0.0328	0.2295	0.3461
Plasmodium vivax	CDK-related protein kinase 6, putative	0.139	1	1
Mycobacterium tuberculosis	Probable hydrolase	0.0084	0.053	0.1302
Schistosoma mansoni	glucose transport protein	0.0328	0.2295	1
Trypanosoma brucei	glucose transporter 1E	0.0102	0.0656	0.8747
Trypanosoma cruzi	lysyl-tRNA synthetase, putative	0.0073	0.045	0.5996
Toxoplasma gondii	calcium-dependent protein kinase CDPK3	0.01	0.0647	0.0976
Trypanosoma cruzi	cytochrome P450, putative	0.0012	0.001	0.0127
Trypanosoma cruzi	threonyl-tRNA synthetase, putative	0.0018	0.0053	0.0711
Echinococcus multilocularis	calcium:calmodulin dependent protein kinase type	0.01	0.0647	0.0997
Plasmodium falciparum	hexose transporter	0.0328	0.2295	0.2295
Leishmania major	hypothetical protein, conserved	0.0016	0.0038	0.0504
Trypanosoma brucei	glucose transporter, putative	0.0102	0.0656	0.8747
Trypanosoma cruzi	glucose transporter, putative	0.0046	0.0254	0.3381
Loa Loa (eye worm)	glycyl-tRNA synthetase	0.0018	0.0053	0.0233
Leishmania major	hypothetical protein, conserved	0.0084	0.053	0.7067
Brugia malayi	RNA binding protein	0.0074	0.0457	0.1957
Echinococcus multilocularis	solute carrier family 22	0.0046	0.0254	0.0391
Entamoeba histolytica	glycyl-tRNA synthetase, putative	0.0018	0.0053	0.0825
Echinococcus multilocularis	General substrate transporter	0.0281	0.1961	0.3021
Mycobacterium tuberculosis	Lysyl-tRNA synthetase 1 LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase)	0.0062	0.037	0.0878
Trypanosoma cruzi	sugar transporter, putative	0.0046	0.0254	0.3381
Mycobacterium tuberculosis	Probable dicarboxylic acid transport integral membrane protein KgtP (dicarboxylate transporter)	0.0046	0.0254	0.0571
Echinococcus granulosus	calcium:calmodulin dependent protein kinase type	0.01	0.0647	0.1964
Leishmania major	glucose transporter, lmgt2	0.0102	0.0656	0.8747
Brugia malayi	Bifunctional aminoacyl-tRNA synthetase	0.0098	0.0632	0.2725
Echinococcus granulosus	General substrate transporter	0.0281	0.1961	0.5953
Trypanosoma cruzi	hexose transporter, putative	0.0102	0.0656	0.8747
Loa Loa (eye worm)	calcium/calmodulin-dependent protein kinase ID	0.01	0.0647	0.2819
Leishmania major	protein kinase, putative	0.01	0.0647	0.8623
Loa Loa (eye worm)	cytochrome P450 family protein	0.0012	0.001	0.0041
Echinococcus granulosus	calcium:calmodulin dependent protein kinase type 1	0.01	0.0647	0.1964
Schistosoma mansoni	glucose transporter	0.0046	0.0254	0.1106
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0158	0.1066	0.3236
Plasmodium falciparum	mitogen-activated protein kinase 2	0.0529	0.3758	0.3758
Plasmodium falciparum	calcium-dependent protein kinase 2	0.01	0.0647	0.0647
Brugia malayi	threonyl-tRNA synthetase, cytoplasmic	0.0018	0.0053	0.0192
Loa Loa (eye worm)	threonyl-tRNA synthetase	0.0018	0.0053	0.0233
Trichomonas vaginalis	sugar transporter, putative	0.0046	0.0254	0.1106
Mycobacterium leprae	Probable lipase LipE	0.0084	0.053	0.8284
Loa Loa (eye worm)	hypothetical protein	0.0046	0.0254	0.1106
Mycobacterium ulcerans	hypothetical protein	0.0016	0.0038	0.0713
Brugia malayi	TAR-binding protein	0.0074	0.0457	0.1957
Trichomonas vaginalis	threonyl-tRNA synthetase, putative	0.0018	0.0053	0.0233
Trypanosoma brucei	cytochrome P450, putative	0.0012	0.001	0.0127
Trichomonas vaginalis	sugar transporter, putative	0.0046	0.0254	0.1106
Brugia malayi	hypothetical protein	0.0046	0.0254	0.1069
Plasmodium falciparum	calcium-dependent protein kinase 5	0.01	0.0647	0.0647
Echinococcus granulosus	glutamyl tRNA synthetase cytoplasmic	0.0098	0.0632	0.1919
Trichomonas vaginalis	sugar transporter, putative	0.0046	0.0254	0.1106
Brugia malayi	bifunctional aminoacyl-tRNA synthetase	0.0098	0.0632	0.2725
Plasmodium falciparum	proline--tRNA ligase	0.0115	0.075	0.075
Mycobacterium leprae	conserved hypothetical protein	0.0084	0.053	0.8284
Trichomonas vaginalis	conserved hypothetical protein	0.0328	0.2295	1
Trichomonas vaginalis	conserved hypothetical protein	0.0046	0.0254	0.1106
Trichomonas vaginalis	sugar transporter, putative	0.0046	0.0254	0.1106
Toxoplasma gondii	sugar transporter ST3	0.0046	0.0254	0.0383
Echinococcus multilocularis	solute carrier family 2, facilitated glucose	0.0328	0.2295	0.3535
Trichomonas vaginalis	sugar transporter, putative	0.0046	0.0254	0.1106
Mycobacterium ulcerans	fusion protein of transposase for IS2606 and sialic acid-transport integral membrane protein NanT	0.0046	0.0254	0.4784
Mycobacterium tuberculosis	Conserved protein	0.0084	0.053	0.1302
Trichomonas vaginalis	sugar transporter, putative	0.0102	0.0656	0.286
Leishmania major	cytochrome p450-like protein	0.0012	0.001	0.0127
Loa Loa (eye worm)	hypothetical protein	0.01	0.0647	0.2819
Mycobacterium tuberculosis	Probable conserved integral membrane transport protein	0.0046	0.0254	0.0571
Echinococcus multilocularis	lysyl tRNA synthetase	0.0073	0.045	0.0693
Trypanosoma cruzi	hexose transporter, putative	0.0102	0.0656	0.8747
Mycobacterium ulcerans	fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE	0.0084	0.053	1
Loa Loa (eye worm)	sugar transporter	0.0328	0.2295	1
Trichomonas vaginalis	penicillin-binding protein, putative	0.0084	0.053	0.2311
Echinococcus granulosus	synaptic vesicle 2 protein	0.0046	0.0254	0.077
Brugia malayi	Sugar transporter family protein	0.0046	0.0254	0.1069
Mycobacterium tuberculosis	Probable lipase LipE	0.0084	0.053	0.1302
Schistosoma mansoni	glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs)	0.0098	0.0632	0.2755
Trichomonas vaginalis	conserved hypothetical protein	0.0102	0.0656	0.286
Toxoplasma gondii	sugar transporter ST2	0.0046	0.0254	0.0383
Trypanosoma cruzi	hexose transporter, putative	0.0056	0.0322	0.4296
Mycobacterium ulcerans	beta-lactamase	0.0084	0.053	1
Trichomonas vaginalis	sugar transporter, putative	0.0046	0.0254	0.1106
Trichomonas vaginalis	glucose transporter, putative	0.0102	0.0656	0.286
Schistosoma mansoni	hypothetical protein	0.0328	0.2295	1
Trichomonas vaginalis	sugar transporter, putative	0.0102	0.0656	0.286
Trypanosoma cruzi	prolyl-tRNA synthetase, putative	0.0115	0.075	1
Plasmodium falciparum	protein kinase 7	0.0925	0.663	0.663
Toxoplasma gondii	cell-cycle-associated protein kinase MAPK, putative	0.0529	0.3758	0.5667
Entamoeba histolytica	threonyl-tRNA synthetase, putative	0.0018	0.0053	0.0825
Trypanosoma cruzi	prolyl-tRNA synthetase, putative	0.0115	0.075	1
Trypanosoma brucei	THT1 - hexose transporter, putative	0.0102	0.0656	0.8747
Echinococcus granulosus	lysyl tRNA synthetase	0.0073	0.045	0.1366
Chlamydia trachomatis	threonine--tRNA ligase	0.0018	0.0053	0.1186
Schistosoma mansoni	lysyl-tRNA synthetase	0.0073	0.045	0.196
Echinococcus multilocularis	neuropeptide s receptor	0.0465	0.3294	0.5075
Echinococcus multilocularis	solute carrier family 2 facilitated glucose	0.0328	0.2295	0.3535
Trichomonas vaginalis	sugar transporter, putative	0.0046	0.0254	0.1106
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0158	0.1066	0.4645
Leishmania major	glucose transporter/membrane transporter D2, putative	0.0102	0.0656	0.8747
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0158	0.1066	0.3236
Mycobacterium ulcerans	sugar transporter	0.0046	0.0254	0.4784
Giardia lamblia	Lysyl-tRNA synthetase	0.0073	0.045	0.6849
Plasmodium falciparum	major facilitator superfamily domain-containing protein, putative	0.0046	0.0254	0.0254
Echinococcus multilocularis	glycyl tRNA synthetase	0.0018	0.0053	0.0082
Loa Loa (eye worm)	hypothetical protein	0.0046	0.0254	0.1106
Echinococcus multilocularis	Threonyl tRNA synthetase, C	0.0018	0.0053	0.0082
Schistosoma mansoni	hypothetical protein	0.017	0.1149	0.5008
Leishmania major	hypothetical protein, conserved	0.0016	0.0038	0.0504
Trypanosoma cruzi	hypothetical protein, conserved	0.0084	0.053	0.7067
Trichomonas vaginalis	sugar transporter, putative	0.0046	0.0254	0.1106
Trichomonas vaginalis	sugar transporter, putative	0.0046	0.0254	0.1106
Schistosoma mansoni	tar DNA-binding protein	0.0074	0.0457	0.1991
Brugia malayi	Major Facilitator Superfamily protein	0.0046	0.0254	0.1069
Loa Loa (eye worm)	hypothetical protein	0.0046	0.0254	0.1106
Mycobacterium ulcerans	glycyl-tRNA synthetase	0.0018	0.0053	0.1006
Trichomonas vaginalis	sugar transporter, putative	0.0102	0.0656	0.286
Echinococcus granulosus	solute carrier family 2 facilitated glucose	0.0328	0.2295	0.6966
Trypanosoma brucei	calcium/calmodulin-dependent protein kinase, putative	0.01	0.0647	0.8623
Loa Loa (eye worm)	hypothetical protein	0.0046	0.0254	0.1106
Echinococcus granulosus	solute carrier family 22	0.0046	0.0254	0.077
Brugia malayi	beta-lactamase family protein	0.0084	0.053	0.2279
Echinococcus multilocularis	synaptic vesicle 2 protein	0.0046	0.0254	0.0391
Brugia malayi	Sugar transporter family protein	0.0328	0.2295	1
Plasmodium vivax	calcium-dependent protein kinase 1, putative	0.01	0.0647	0.0647
Trypanosoma brucei	THT1 - hexose transporter, putative	0.0102	0.0656	0.8747
Brugia malayi	RNA recognition motif domain containing protein	0.0074	0.0457	0.1957
Plasmodium falciparum	lysine--tRNA ligase	0.0073	0.045	0.045
Onchocerca volvulus		0.0084	0.053	1
Loa Loa (eye worm)	hypothetical protein	0.0084	0.053	0.2311
Trichomonas vaginalis	sugar transporter, putative	0.0046	0.0254	0.1106
Schistosoma mansoni	protein kinase	0.01	0.0647	0.2819
Trichomonas vaginalis	sugar transporter, putative	0.0046	0.0254	0.1106
Schistosoma mansoni	protein kinase	0.01	0.0647	0.2819
Mycobacterium ulcerans	sugar-transport integral membrane protein SugI	0.0046	0.0254	0.4784
Trypanosoma brucei	myo-inositol/proton symporter (MIT)	0.0046	0.0254	0.3381
Leishmania major	lysyl-tRNA synthetase, putative	0.0073	0.045	0.5996
Brugia malayi	major facilitator superfamily protein	0.0046	0.0254	0.1069
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0158	0.1066	0.1642
Onchocerca volvulus		0.0084	0.053	1
Trichomonas vaginalis	conserved hypothetical protein	0.0102	0.0656	0.286
Loa Loa (eye worm)	hypothetical protein	0.0046	0.0254	0.1106
Trichomonas vaginalis	D-aminoacylase, putative	0.0084	0.053	0.2311
Trichomonas vaginalis	sugar transporter, putative	0.0046	0.0254	0.1106
Chlamydia trachomatis	proline--tRNA ligase	0.0035	0.0171	0.3811
Brugia malayi	Sugar transporter family protein	0.0046	0.0254	0.1069
Loa Loa (eye worm)	hypothetical protein	0.0046	0.0254	0.1106
Loa Loa (eye worm)	CAMK/CAMK2 protein kinase	0.01	0.0647	0.2819
Trichomonas vaginalis	sugar transporter, putative	0.0046	0.0254	0.1106
Loa Loa (eye worm)	beta-LACTamase domain containing family member	0.0084	0.053	0.2311
Trichomonas vaginalis	sugar transporter, putative	0.0046	0.0254	0.1106
Toxoplasma gondii	YbaK/proline-tRNA ligase associated domain-containing protein	0.0016	0.0038	0.0057
Mycobacterium ulcerans	lipase LipD	0.0084	0.053	1
Echinococcus multilocularis	glutamyl tRNA synthetase cytoplasmic	0.0098	0.0632	0.0974
Trichomonas vaginalis	myo-inositol transporter, putative	0.0046	0.0254	0.1106
Brugia malayi	Calcium/calmodulin-dependent protein kinase type II alpha chain	0.01	0.0647	0.279
Toxoplasma gondii	sugar transporter ST1	0.0046	0.0254	0.0383
Echinococcus granulosus	calcium:calmodulin dependent protein kinase type	0.01	0.0647	0.1964
Echinococcus granulosus	tar DNA binding protein	0.0074	0.0457	0.1387
Trypanosoma cruzi	hypothetical protein, conserved	0.0084	0.053	0.7067
Plasmodium falciparum	calcium-dependent protein kinase 1	0.01	0.0647	0.0647
Leishmania major	prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative	0.0115	0.075	1
Loa Loa (eye worm)	RNA recognition domain-containing protein domain-containing protein	0.0074	0.0457	0.1991
Trypanosoma brucei	glucose transporter, putative	0.0102	0.0656	0.8747
Trichomonas vaginalis	sugar transporter, putative	0.0046	0.0254	0.1106
Toxoplasma gondii	calcium-dependent protein kinase CDPK2A	0.01	0.0647	0.0976
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0158	0.1066	0.1642
Plasmodium vivax	hexose transporter	0.0328	0.2295	0.2295
Toxoplasma gondii	threonyl-tRNA synthetase family protein	0.0018	0.0053	0.008
Wolbachia endosymbiont of Brugia malayi	major facilitator superfamily permease	0.0046	0.0254	1
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0084	0.053	0.2311
Brugia malayi	Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative	0.0084	0.053	0.2279
Schistosoma mansoni	glycyl-tRNA synthetase	0.0018	0.0053	0.0233
Plasmodium vivax	calcium-dependent protein kinase 3, putative	0.01	0.0647	0.0647
Trichomonas vaginalis	sugar transporter, putative	0.0046	0.0254	0.1106
Mycobacterium ulcerans	esterase/lipase LipP	0.0084	0.053	1
Loa Loa (eye worm)	hypothetical protein	0.0084	0.053	0.2311
Mycobacterium leprae	Possible lysyl-tRNA synthetase 2 LysX	0.0073	0.045	0.6932
Loa Loa (eye worm)	major facilitator superfamily transporter	0.0046	0.0254	0.1106
Leishmania major	prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative	0.0115	0.075	1
Schistosoma mansoni	nuclear transcription factor X-box binding 1 (nfx1)	0.0046	0.0254	0.1106
Brugia malayi	beta-lactamase family protein	0.0084	0.053	0.2279
Brugia malayi	hypothetical protein	0.0046	0.0254	0.1069
Trichomonas vaginalis	sugar transporter, putative	0.0046	0.0254	0.1106
Mycobacterium tuberculosis	Probable esterase/lipase LipP	0.0084	0.053	0.1302
Leishmania major	myo-inositol/proton symporter (MIT)	0.0046	0.0254	0.3381
Giardia lamblia	Hexose transporter	0.0046	0.0254	0.346
Trichomonas vaginalis	sugar transporter, putative	0.0046	0.0254	0.1106
Trichomonas vaginalis	lysyl-tRNA synthetase, putative	0.0064	0.0385	0.1676
Loa Loa (eye worm)	hypothetical protein	0.0084	0.053	0.2311
Trypanosoma brucei	glucose transporter, putative	0.0102	0.0656	0.8747
Brugia malayi	Major Facilitator Superfamily protein	0.0046	0.0254	0.1069
Brugia malayi	Major Facilitator Superfamily protein	0.0046	0.0254	0.1069
Schistosoma mansoni	hypothetical protein	0.017	0.1149	0.5008
Trypanosoma brucei	sugar transporter, putative	0.0046	0.0254	0.3381
Trypanosoma cruzi	hexose transporter, putative	0.0046	0.0254	0.3381
Trichomonas vaginalis	conserved hypothetical protein	0.0046	0.0254	0.1106
Treponema pallidum	prolyl-tRNA synthetase	0.0035	0.0171	1
Giardia lamblia	Prolyl-tRNA synthetase	0.0098	0.0632	1
Trypanosoma cruzi	hypothetical protein, conserved	0.0016	0.0038	0.0504
Trichomonas vaginalis	conserved hypothetical protein	0.0046	0.0254	0.1106
Entamoeba histolytica	prolyl-tRNA synthetase, putative	0.0098	0.0632	0.9772
Trypanosoma brucei	THT1 - hexose transporter, putative	0.0102	0.0656	0.8747
Loa Loa (eye worm)	hypothetical protein	0.0073	0.045	0.196
Trypanosoma brucei	glucose transporter, putative	0.0102	0.0656	0.8747
Schistosoma mansoni	glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs)	0.0098	0.0632	0.2755
Echinococcus granulosus	solute carrier family 22	0.0046	0.0254	0.077
Loa Loa (eye worm)	hypothetical protein	0.0046	0.0254	0.1106
Schistosoma mansoni	sugar transporter	0.0046	0.0254	0.1106
Loa Loa (eye worm)	bifunctional aminoacyl-tRNA synthetase	0.004	0.0212	0.0925
Trypanosoma brucei	lysyl-tRNA synthetase, putative	0.0073	0.045	0.5996
Schistosoma mansoni	tar DNA-binding protein	0.0074	0.0457	0.1991
Loa Loa (eye worm)	hypothetical protein	0.0098	0.0632	0.2755
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0158	0.1066	0.4645

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

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Bibliographic References

No literature references available for this target.

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Detailed information for compound 763593