TDR Targets

Basic information

Technical information

TDR Targets ID: 763635
Name: 2-(5-acetyl-4-methyl-1,3-thiazol-2-yl)-1-phen yl-1H-chromeno[2,3-c]pyrrole-3,9-dione
MW: 416.449 | Formula: C23H16N2O4S
H donors: 0 H acceptors: 4 LogP: 3.83 Rotable bonds: 3
Rule of 5 violations (Lipinski): 1
SMILES: CC(=O)c1sc(nc1C)N1C(=O)c2c(C1c1ccccc1)c(=O)c1c(o2)cccc1
InChi: 1S/C23H16N2O4S/c1-12-21(13(2)26)30-23(24-12)25-18(14-8-4-3-5-9-14)17-19(27)15-10-6-7-11-16(15)29-20(17)22(25)28/h3-11,18H,1-2H3
InChiKey: YCSCOYMJJFAKMA-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

2-(5-acetyl-4-methyl-thiazol-2-yl)-1-phenyl-1H-chromeno[2,3-c]pyrrole-3,9-dione
2-(5-acetyl-4-methyl-2-thiazolyl)-1-phenyl-1H-chromeno[2,3-c]pyrrole-3,9-dione
2-(5-acetyl-4-methyl-thiazol-2-yl)-1-phenyl-1H-chromeno[2,3-c]pyrrole-3,9-quinone
2-(5-ethanoyl-4-methyl-1,3-thiazol-2-yl)-1-phenyl-1H-chromeno[2,3-c]pyrrole-3,9-dione

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0201	0.0894
Trichomonas vaginalis	sugar transporter, putative	0.0031	0.0201	0.0894
Onchocerca volvulus	Sodium\/hydrogen exchanger homolog	0.0143	0.1436	1
Echinococcus granulosus	sodium:hydrogen exchanger 7	0.0027	0.0165	0.0733
Plasmodium falciparum	mitogen-activated protein kinase 2	0.0351	0.3724	0.3724
Schistosoma mansoni	serine/threonine protein kinase	0.0067	0.0597	0.2648
Plasmodium falciparum	calcium-dependent protein kinase 3	0.0067	0.0597	0.0597
Trichomonas vaginalis	conserved hypothetical protein	0.0217	0.2253	1
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0201	0.0894
Wolbachia endosymbiont of Brugia malayi	Kef-type K+ transport system, membrane component	0.0027	0.0165	0.82
Echinococcus multilocularis	lysyl tRNA synthetase	0.0049	0.0399	0.1769
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0201	0.0894
Echinococcus multilocularis	General substrate transporter	0.0187	0.1918	0.851
Loa Loa (eye worm)	sodium-hydrogen exchanger NHE1	0.0027	0.0165	0.0733
Loa Loa (eye worm)	hypothetical protein	0.0065	0.0582	0.2583
Mycobacterium tuberculosis	Probable dicarboxylic acid transport integral membrane protein KgtP (dicarboxylate transporter)	0.0031	0.0201	0.6328
Mycobacterium leprae	Probable prolyl tRNA synthetase ProS	0.0065	0.0582	1
Trypanosoma cruzi	lysyl-tRNA synthetase, putative	0.0049	0.0399	0.5689
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0165	0.0733
Leishmania major	myo-inositol/proton symporter (MIT)	0.0031	0.0201	0.2874
Trypanosoma brucei	lysyl-tRNA synthetase, putative	0.0049	0.0399	0.5689
Echinococcus granulosus	solute carrier family 2 facilitated glucose	0.0217	0.2253	1
Echinococcus multilocularis	solute carrier family 22	0.0031	0.0201	0.0894
Leishmania major	Na/H antiporter-like protein	0.0027	0.0165	0.2357
Schistosoma mansoni	protein kinase	0.0067	0.0597	0.2648
Trichomonas vaginalis	sugar transporter, putative	0.0031	0.0201	0.0894
Trypanosoma brucei	sugar transporter, putative	0.0031	0.0201	0.2874
Schistosoma mansoni	nuclear transcription factor X-box binding 1 (nfx1)	0.0031	0.0201	0.0894
Leishmania major	lysyl-tRNA synthetase, putative	0.0049	0.0399	0.5689
Plasmodium falciparum	major facilitator superfamily domain-containing protein, putative	0.0031	0.0201	0.0201
Echinococcus multilocularis	sodium:hydrogen exchanger 2 (nhe2)	0.0143	0.1436	0.6373
Toxoplasma gondii	protein kinase, putative	0.0614	0.6612	1
Leishmania major	glucose transporter/membrane transporter D2, putative	0.0067	0.0606	0.8651
Mycobacterium ulcerans	lysyl-tRNA synthetase	0.0049	0.0399	1
Trichomonas vaginalis	myo-inositol transporter, putative	0.0031	0.0201	0.0894
Loa Loa (eye worm)	sugar transporter	0.0217	0.2253	1
Trypanosoma brucei	myo-inositol/proton symporter (MIT)	0.0031	0.0201	0.2874
Schistosoma mansoni	protein kinase	0.0067	0.0597	0.2648
Trichomonas vaginalis	sugar transporter, putative	0.0031	0.0201	0.0894
Trichomonas vaginalis	sugar transporter, putative	0.0031	0.0201	0.0894
Plasmodium vivax	calcium-dependent protein kinase 3, putative	0.0067	0.0597	0.0597
Brugia malayi	Major Facilitator Superfamily protein	0.0031	0.0201	0.0894
Plasmodium vivax	lysine--tRNA ligase, putative	0.0049	0.0399	0.0399
Echinococcus granulosus	solute carrier family 22	0.0031	0.0201	0.0894
Echinococcus granulosus	sodium:hydrogen exchanger 2 (nhe2)	0.0116	0.1137	0.5044
Leishmania major	glucose transporter, lmgt2	0.0067	0.0606	0.8651
Echinococcus granulosus	sodium:hydrogen exchanger	0.0143	0.1436	0.6373
Onchocerca volvulus		0.0031	0.0201	0.0285
Plasmodium vivax	mitogen-activated protein kinase 2, putative	0.0351	0.3724	0.3724
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0201	0.0894
Echinococcus multilocularis	Sugar transporter ERD6 protein	0.0031	0.0201	0.0894
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0201	0.0894
Trichomonas vaginalis	sugar transporter, putative	0.0031	0.0201	0.0894
Loa Loa (eye worm)	sodium/hydrogen exchanger 3 family protein	0.0143	0.1436	0.6373
Trichomonas vaginalis	glucose transporter, putative	0.0031	0.0201	0.0894
Echinococcus multilocularis	calcium:calmodulin dependent protein kinase type	0.0067	0.0597	0.2648
Echinococcus granulosus	glutamyl tRNA synthetase cytoplasmic	0.0065	0.0582	0.2583
Trichomonas vaginalis	conserved hypothetical protein	0.0067	0.0606	0.269
Plasmodium vivax	sodium/hydrogen exchanger 1, putative	0.0027	0.0165	0.0165
Brugia malayi	bifunctional aminoacyl-tRNA synthetase	0.0065	0.0582	0.2583
Echinococcus granulosus	sodium:hydrogen exchanger	0.0143	0.1436	0.6373
Brugia malayi	sodium/hydrogen exchanger 3 family protein	0.0143	0.1436	0.6373
Trichomonas vaginalis	sugar transporter, putative	0.0067	0.0606	0.269
Echinococcus granulosus	solute carrier family 2 facilitated glucose	0.0217	0.2253	1
Giardia lamblia	Hexose transporter	0.0031	0.0201	0.1402
Trichomonas vaginalis	sugar transporter, putative	0.0031	0.0201	0.0894
Schistosoma mansoni	sugar transporter	0.0031	0.0201	0.0894
Trichomonas vaginalis	sugar transport protein, putative	0.0031	0.0201	0.0894
Mycobacterium ulcerans	fusion protein of transposase for IS2606 and sialic acid-transport integral membrane protein NanT	0.0031	0.0201	0.5052
Entamoeba histolytica	prolyl-tRNA synthetase, putative	0.0065	0.0582	0.9752
Brugia malayi	Cam kinase protein 1	0.0067	0.0597	0.2648
Trypanosoma cruzi	sodium/hydrogen exchanger, putative	0.0027	0.0165	0.2357
Trichomonas vaginalis	sugar transporter, putative	0.0031	0.0201	0.0894
Trichomonas vaginalis	sugar transporter, putative	0.0031	0.0201	0.0894
Echinococcus multilocularis	solute carrier family 2 facilitated glucose	0.0217	0.2253	1
Loa Loa (eye worm)	hypothetical protein	0.0143	0.1436	0.6373
Mycobacterium ulcerans	integral membrane transport protein	0.0031	0.0201	0.5052
Leishmania major	hypothetical protein, conserved	0.0031	0.0201	0.2874
Loa Loa (eye worm)	major facilitator superfamily transporter	0.0031	0.0201	0.0894
Plasmodium vivax	CDK-related protein kinase 6, putative	0.0922	1	1
Onchocerca volvulus		0.0031	0.0201	0.0285
Echinococcus granulosus	General substrate transporter	0.0187	0.1918	0.851
Trypanosoma cruzi	prolyl-tRNA synthetase, putative	0.0076	0.0701	1
Loa Loa (eye worm)	sugar transporter	0.0031	0.0201	0.0894
Toxoplasma gondii	sodium/hydrogen exchanger NHE2	0.0027	0.0165	0.025
Toxoplasma gondii	Na+/H+ exchanger NHE1	0.0027	0.0165	0.025
Trypanosoma brucei	glucose transporter 2A	0.0067	0.0606	0.8651
Leishmania major	protein kinase, putative	0.0067	0.0597	0.8517
Trichomonas vaginalis	sugar transporter, putative	0.0031	0.0201	0.0894
Schistosoma mansoni	protein kinase	0.0067	0.0597	0.2648
Schistosoma mansoni	sugar transporter	0.0031	0.0201	0.0894
Trypanosoma brucei	bifunctional aminoacyl-tRNA synthetase, putative	0.0076	0.0701	1
Brugia malayi	major facilitator superfamily protein	0.0031	0.0201	0.0894
Echinococcus multilocularis	sodium:hydrogen exchanger 7	0.0027	0.0165	0.0733
Schistosoma mansoni	glucose transport protein	0.0217	0.2253	1
Echinococcus multilocularis	mitochondrial sodium:hydrogen exchanger 9B2	0.0027	0.0165	0.0733
Brugia malayi	Major Facilitator Superfamily protein	0.0031	0.0201	0.0894
Trichomonas vaginalis	sugar transporter, putative	0.0031	0.0201	0.0894
Echinococcus multilocularis	synaptic vesicle 2 protein	0.0031	0.0201	0.0894
Schistosoma mansoni	sodium/hydrogen exchanger 3 (nhe3)	0.0027	0.0165	0.0733
Mycobacterium leprae	Probable lysyl-tRNA synthase LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase)	0.0041	0.0318	0.5469
Trypanosoma cruzi	hexose transporter, putative	0.0037	0.027	0.386
Onchocerca volvulus		0.0031	0.0201	0.0285
Brugia malayi	Major Facilitator Superfamily protein	0.0031	0.0201	0.0894
Toxoplasma gondii	cell-cycle-associated protein kinase MAPK, putative	0.0351	0.3724	0.5632
Toxoplasma gondii	lysine-tRNA ligase	0.0049	0.0399	0.0603
Plasmodium falciparum	calcium-dependent protein kinase 5	0.0067	0.0597	0.0597
Brugia malayi	Sugar transporter family protein	0.0031	0.0201	0.0894
Brugia malayi	major facilitator superfamily protein	0.0031	0.0201	0.0894
Giardia lamblia	Sugar-proton symporter	0.0031	0.0201	0.1402
Trichomonas vaginalis	sugar transporter, putative	0.0031	0.0201	0.0894
Echinococcus multilocularis	sodium:hydrogen exchanger	0.0143	0.1436	0.6373
Echinococcus multilocularis	solute carrier family 22	0.0031	0.0201	0.0894
Trichomonas vaginalis	sugar transporter, putative	0.0031	0.0201	0.0894
Trypanosoma brucei	THT1 - hexose transporter, putative	0.0067	0.0606	0.8651
Onchocerca volvulus		0.0031	0.0201	0.0285
Echinococcus granulosus	sodium:hydrogen exchanger 2 nhe2	0.0143	0.1436	0.6373
Loa Loa (eye worm)	hypothetical protein	0.0049	0.0399	0.1769
Plasmodium falciparum	calcium-dependent protein kinase 1	0.0067	0.0597	0.0597
Trypanosoma cruzi	hexose transporter, putative	0.0031	0.0201	0.2874
Brugia malayi	Calcium/calmodulin-dependent protein kinase type II alpha chain	0.0067	0.0597	0.2648
Trypanosoma cruzi	hexose transporter, putative	0.0067	0.0606	0.8651
Echinococcus multilocularis	calcium:calmodulin dependent protein kinase type	0.0067	0.0597	0.2648
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0201	0.0894
Trypanosoma cruzi	Na/H antiporter-like protein, putative	0.0027	0.0165	0.2357
Mycobacterium ulcerans	membrane transporter	0.0027	0.0165	0.4143
Trypanosoma cruzi	hexose transporter, putative	0.0067	0.0606	0.8651
Entamoeba histolytica	protein kinase, putative	0.0067	0.0597	1
Giardia lamblia	Prolyl-tRNA synthetase	0.0065	0.0582	0.4053
Echinococcus granulosus	calcium:calmodulin dependent protein kinase type	0.0067	0.0597	0.2648
Trichomonas vaginalis	sugar transporter, putative	0.0031	0.0201	0.0894
Onchocerca volvulus		0.0031	0.0201	0.0285
Trichomonas vaginalis	sugar transporter, putative	0.0031	0.0201	0.0894
Echinococcus granulosus	sodium:hydrogen exchanger 2 nhe2	0.0143	0.1436	0.6373
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0201	0.0894
Mycobacterium ulcerans	ion antiporter, NhaP	0.0027	0.0165	0.4143
Echinococcus multilocularis	sodium:hydrogen exchanger 2 (nhe2)	0.0116	0.1137	0.5044
Trypanosoma cruzi	prolyl-tRNA synthetase, putative	0.0076	0.0701	1
Schistosoma mansoni	lysyl-tRNA synthetase	0.0049	0.0399	0.1769
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0201	0.0894
Onchocerca volvulus	Putative transporter	0.0031	0.0201	0.0285
Trichomonas vaginalis	conserved hypothetical protein	0.0031	0.0201	0.0894
Mycobacterium tuberculosis	Probable conserved integral membrane transport protein YjcE	0.0027	0.0165	0.5189
Onchocerca volvulus		0.0031	0.0201	0.0285
Trichomonas vaginalis	glucose transporter, putative	0.0067	0.0606	0.269
Trichomonas vaginalis	sugar transporter, putative	0.0031	0.0201	0.0894
Giardia lamblia	Lysyl-tRNA synthetase	0.0049	0.0399	0.2776
Echinococcus granulosus	solute carrier family 2 facilitated glucose	0.0217	0.2253	1
Plasmodium falciparum	protein kinase 7	0.0614	0.6612	0.6612
Echinococcus multilocularis	sodium:hydrogen exchanger 2 (nhe2)	0.0143	0.1436	0.6373
Leishmania major	prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative	0.0076	0.0701	1
Echinococcus granulosus	sodium:hydrogen exchanger 2 nhe2	0.0143	0.1436	0.6373
Onchocerca volvulus		0.0031	0.0201	0.0285
Onchocerca volvulus		0.0031	0.0201	0.0285
Plasmodium vivax	calcium-dependent protein kinase 4, putative	0.0067	0.0597	0.0597
Trypanosoma cruzi	sodium/hydrogen exchanger, putative	0.0027	0.0165	0.2357
Echinococcus multilocularis	sodium:hydrogen exchanger	0.0143	0.1436	0.6373
Echinococcus multilocularis	solute carrier family 2, facilitated glucose	0.0217	0.2253	1
Echinococcus granulosus	solute carrier family 2 facilitated glucose	0.0217	0.2253	1
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0165	0.0733
Onchocerca volvulus		0.0031	0.0201	0.0285
Schistosoma mansoni	sodium/hydrogen exchanger 2 (nhe2)	0.0143	0.1436	0.6373
Toxoplasma gondii	sugar transporter ST3	0.0031	0.0201	0.0305
Trichomonas vaginalis	sugar transporter, putative	0.0031	0.0201	0.0894
Trichomonas vaginalis	lysyl-tRNA synthetase, putative	0.0049	0.0399	0.1769
Loa Loa (eye worm)	sodium/hydrogen exchanger	0.0143	0.1436	0.6373
Trichomonas vaginalis	sugar transporter, putative	0.0031	0.0201	0.0894
Trichomonas vaginalis	sugar transporter, putative	0.0031	0.0201	0.0894
Brugia malayi	Sugar transporter family protein	0.0031	0.0201	0.0894
Toxoplasma gondii	sodium/hydrogen exchanger 3 protein	0.0027	0.0165	0.025
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0201	0.0894
Trypanosoma brucei	glucose transporter 1E	0.0067	0.0606	0.8651
Schistosoma mansoni	glucose transport protein	0.0217	0.2253	1
Trichomonas vaginalis	sugar transporter, putative	0.0067	0.0606	0.269
Echinococcus granulosus	solute carrier family 22	0.0031	0.0201	0.0894
Plasmodium vivax	sugar transporter, putative	0.0031	0.0201	0.0201
Mycobacterium tuberculosis	Lysyl-tRNA synthetase 2 LysX	0.0041	0.0318	1
Trypanosoma brucei	glucose transporter, putative	0.0067	0.0606	0.8651
Plasmodium falciparum	calcium-dependent protein kinase 4	0.0067	0.0597	0.0597
Schistosoma mansoni	glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs)	0.0065	0.0582	0.2583
Trichomonas vaginalis	conserved hypothetical protein	0.0031	0.0201	0.0894
Onchocerca volvulus		0.0031	0.0201	0.0285
Echinococcus granulosus	calcium:calmodulin dependent protein kinase type	0.0067	0.0597	0.2648
Echinococcus multilocularis	solute carrier family 2 facilitated glucose	0.0217	0.2253	1
Entamoeba histolytica	hypothetical protein	0.0049	0.0399	0.6679
Trichomonas vaginalis	lysyl-tRNA synthetase, putative	0.0043	0.0333	0.1477
Echinococcus granulosus	synaptic vesicle 2 protein	0.0031	0.0201	0.0894
Trichomonas vaginalis	sugar transporter, putative	0.0031	0.0201	0.0894
Trypanosoma cruzi	hexose transporter, putative	0.0067	0.0606	0.8651
Toxoplasma gondii	Na+/H+ exchanger NHE3	0.0027	0.0165	0.025
Echinococcus granulosus	calcium:calmodulin dependent protein kinase type	0.0067	0.0597	0.2648
Echinococcus multilocularis	solute carrier family 22	0.0031	0.0201	0.0894
Schistosoma mansoni	lysyl-tRNA synthetase	0.0049	0.0399	0.1769
Mycobacterium ulcerans	prolyl-tRNA synthetase	0.0023	0.0119	0.2978
Trypanosoma brucei	glucose transporter, putative	0.0067	0.0606	0.8651
Echinococcus granulosus	calcium:calmodulin dependent protein kinase type 1	0.0067	0.0597	0.2648
Plasmodium vivax	hexose transporter	0.0217	0.2253	0.2253
Toxoplasma gondii	transporter, major facilitator family protein	0.0031	0.0201	0.0305
Schistosoma mansoni	hypothetical protein	0.0217	0.2253	1
Loa Loa (eye worm)	NHE-3	0.0143	0.1436	0.6373
Trypanosoma brucei	glucose transporter, putative	0.0067	0.0606	0.8651
Trichomonas vaginalis	sugar transporter, putative	0.0031	0.0201	0.0894
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0201	0.0894
Schistosoma mansoni	glucose transporter	0.0031	0.0201	0.0894
Trichomonas vaginalis	sugar transporter, putative	0.0031	0.0201	0.0894
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0201	0.0894
Trichomonas vaginalis	sugar transporter, putative	0.0031	0.0201	0.0894
Plasmodium falciparum	calcium-dependent protein kinase 2	0.0067	0.0597	0.0597
Loa Loa (eye worm)	hypothetical protein	0.0065	0.0582	0.2583
Entamoeba histolytica	sodium/proton antiporter, putative	0.0027	0.0165	0.2767
Mycobacterium tuberculosis	Lysyl-tRNA synthetase 1 LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase)	0.0041	0.0318	1
Onchocerca volvulus	Sodium\/hydrogen exchanger homolog	0.0143	0.1436	1
Loa Loa (eye worm)	hypothetical protein	0.0067	0.0597	0.2648
Entamoeba histolytica	sodium/proton antiporter, putative	0.0027	0.0165	0.2767
Brugia malayi	Sugar transporter family protein	0.0217	0.2253	1
Brugia malayi	sodium/hydrogen exchanger 3 family protein	0.0027	0.0165	0.0733
Schistosoma mansoni	hypothetical protein	0.0027	0.0165	0.0733
Plasmodium falciparum	hexose transporter	0.0217	0.2253	0.2253
Trichomonas vaginalis	sugar transporter, putative	0.0031	0.0201	0.0894
Leishmania major	glucose transporter, lmgt1	0.0067	0.0606	0.8651
Trypanosoma cruzi	hexose transporter	0.0067	0.0606	0.8651
Trypanosoma cruzi	Na/H antiporter-like protein, putative	0.0027	0.0165	0.2357
Trypanosoma brucei	glucose transporter, putative	0.0067	0.0606	0.8651
Echinococcus multilocularis	solute carrier family 2 facilitated glucose	0.0217	0.2253	1
Mycobacterium leprae	Possible lysyl-tRNA synthetase 2 LysX	0.0049	0.0399	0.6849
Trichomonas vaginalis	sugar transporter, putative	0.0031	0.0201	0.0894
Brugia malayi	hypothetical protein	0.0031	0.0201	0.0894
Brugia malayi	hypothetical protein	0.0031	0.0201	0.0894
Onchocerca volvulus	Sodium\/hydrogen exchanger homolog	0.0143	0.1436	1
Trypanosoma cruzi	sugar transporter, putative	0.0031	0.0201	0.2874
Brugia malayi	hypothetical protein	0.0027	0.0165	0.0733
Trichomonas vaginalis	conserved hypothetical protein	0.0067	0.0606	0.269
Trypanosoma brucei	glucose transporter, putative	0.0067	0.0606	0.8651
Trypanosoma brucei	glucose transporter, putative	0.0067	0.0606	0.8651
Trypanosoma brucei	THT1 - hexose transporter, putative	0.0067	0.0606	0.8651
Loa Loa (eye worm)	hypothetical protein	0.0143	0.1436	0.6373
Echinococcus multilocularis	calcium:calmodulin dependent protein kinase type	0.0067	0.0597	0.2648
Trichomonas vaginalis	CAMK family protein kinase	0.0067	0.0597	0.2648
Trypanosoma brucei	calcium/calmodulin-dependent protein kinase, putative	0.0067	0.0597	0.8517
Trichomonas vaginalis	sugar transporter, putative	0.0031	0.0201	0.0894
Mycobacterium tuberculosis	Probable conserved integral membrane transport protein	0.0031	0.0201	0.6328
Loa Loa (eye worm)	hypothetical protein	0.0143	0.1436	0.6373
Trichomonas vaginalis	sugar transporter, putative	0.0031	0.0201	0.0894
Mycobacterium ulcerans	potassium/proton antiporter	0.0027	0.0165	0.4143
Schistosoma mansoni	glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs)	0.0065	0.0582	0.2583
Mycobacterium leprae	probable conserved integral membrane transport protein	0.0027	0.0165	0.2838
Trichomonas vaginalis	prolyl-tRNA synthetase, putative	0.0065	0.0582	0.2583
Trypanosoma brucei	glucose transporter, putative	0.0067	0.0606	0.8651
Plasmodium vivax	calcium-dependent protein kinase, putative	0.0067	0.0597	0.0597
Onchocerca volvulus		0.0031	0.0201	0.0285
Loa Loa (eye worm)	calcium/calmodulin-dependent protein kinase ID	0.0067	0.0597	0.2648
Trichomonas vaginalis	sugar transporter, putative	0.0031	0.0201	0.0894
Trichomonas vaginalis	sugar transporter, putative	0.0031	0.0201	0.0894
Chlamydia trachomatis	proline--tRNA ligase	0.0023	0.0119	0.2978
Echinococcus granulosus	solute carrier family 22	0.0031	0.0201	0.0894
Echinococcus multilocularis	sodium:hydrogen exchanger 2 (nhe2)	0.0143	0.1436	0.6373
Trichomonas vaginalis	sugar transporter, putative	0.0067	0.0606	0.269
Onchocerca volvulus		0.0031	0.0201	0.0285
Echinococcus multilocularis	solute carrier family 22	0.0031	0.0201	0.0894
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0201	0.0894
Plasmodium falciparum	proline--tRNA ligase	0.0076	0.0701	0.0701
Toxoplasma gondii	calcium-dependent protein kinase CDPK3	0.0067	0.0597	0.0903
Loa Loa (eye worm)	bifunctional aminoacyl-tRNA synthetase	0.0027	0.016	0.0709
Plasmodium vivax	proline--tRNA ligase, putative	0.0076	0.0701	0.0701
Schistosoma mansoni	sodium/hydrogen exchanger	0.0143	0.1436	0.6373
Toxoplasma gondii	facilitative glucose transporter GT1	0.0217	0.2253	0.3408
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0201	0.0894
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0201	0.0894
Trichomonas vaginalis	sugar transporter, putative	0.0031	0.0201	0.0894
Echinococcus granulosus	calcium dependent protein kinase	0.0062	0.0552	0.2448
Echinococcus granulosus	lysyl tRNA synthetase	0.0049	0.0399	0.1769
Toxoplasma gondii	calcium-dependent protein kinase CDPK2B	0.0067	0.0597	0.0903
Trichomonas vaginalis	sugar transporter, putative	0.0031	0.0201	0.0894
Mycobacterium ulcerans	sugar-transport integral membrane protein SugI	0.0031	0.0201	0.5052
Echinococcus granulosus	Sugar transporter ERD6 protein	0.0031	0.0201	0.0894
Toxoplasma gondii	prolyl-tRNA synthetase (ProRS)	0.0076	0.0701	0.106
Echinococcus granulosus	solute carrier family 22	0.0031	0.0201	0.0894
Schistosoma mansoni	sugar transporter	0.0031	0.0201	0.0894
Brugia malayi	Bifunctional aminoacyl-tRNA synthetase	0.0065	0.0582	0.2583
Brugia malayi	hypothetical protein	0.0031	0.0201	0.0894
Trichomonas vaginalis	conserved hypothetical protein	0.0031	0.0201	0.0894
Trichomonas vaginalis	sugar transporter, putative	0.0031	0.0201	0.0894
Mycobacterium ulcerans	sugar transporter	0.0031	0.0201	0.5052
Plasmodium falciparum	sodium/hydrogen exchanger, Na+, H+ antiporter	0.0027	0.0165	0.0165
Trichomonas vaginalis	sugar transporter, putative	0.0031	0.0201	0.0894
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0201	0.0894
Trichomonas vaginalis	sugar transporter, putative	0.0031	0.0201	0.0894
Leishmania major	prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative	0.0076	0.0701	1
Schistosoma mansoni	sugar transporter	0.0031	0.0201	0.0894
Entamoeba histolytica	protein kinase, putative	0.0067	0.0597	1
Onchocerca volvulus		0.0031	0.0201	0.0285
Loa Loa (eye worm)	hypothetical protein	0.0053	0.0448	0.1987
Brugia malayi	Sodium/hydrogen exchanger 8	0.0027	0.0165	0.0733
Leishmania major	hypothetical protein, conserved	0.0027	0.0165	0.2357
Echinococcus multilocularis	glutamyl tRNA synthetase cytoplasmic	0.0065	0.0582	0.2583
Echinococcus multilocularis	calcium dependent protein kinase	0.0062	0.0552	0.2448
Treponema pallidum	prolyl-tRNA synthetase	0.0023	0.0119	1
Mycobacterium tuberculosis	Probable conserved integral membrane transport protein	0.0027	0.0165	0.5189
Trichomonas vaginalis	glucose transporter, putative	0.0067	0.0606	0.269
Onchocerca volvulus		0.0031	0.0201	0.0285
Echinococcus multilocularis	calcium:calmodulin dependent protein kinase type	0.0067	0.0597	0.2648
Toxoplasma gondii	calcium-dependent protein kinase CDPK2A	0.0067	0.0597	0.0903
Brugia malayi	lysyl-tRNA synthetase	0.0049	0.0399	0.1769
Schistosoma mansoni	hypothetical protein	0.0027	0.0165	0.0733
Trichomonas vaginalis	conserved hypothetical protein	0.0031	0.0201	0.0894
Trypanosoma cruzi	glucose transporter, putative	0.0031	0.0201	0.2874
Schistosoma mansoni	glucose transport protein	0.0217	0.2253	1
Leishmania major	glucose transporter, lmgt3	0.0067	0.0606	0.8651
Plasmodium vivax	calcium-dependent protein kinase 1, putative	0.0067	0.0597	0.0597
Trichomonas vaginalis	sugar transporter, putative	0.0031	0.0201	0.0894
Plasmodium falciparum	lysine--tRNA ligase	0.0049	0.0399	0.0399
Trichomonas vaginalis	conserved hypothetical protein	0.0031	0.0201	0.0894
Mycobacterium ulcerans	lysyl-tRNA synthetase	0.0049	0.0399	1
Onchocerca volvulus		0.0031	0.0201	0.0285
Loa Loa (eye worm)	CAMK/CAMK2 protein kinase	0.0067	0.0597	0.2648
Schistosoma mansoni	Slc9a7 protein	0.0027	0.0165	0.0733
Trypanosoma brucei	THT1 - hexose transporter, putative	0.0067	0.0606	0.8651
Trichomonas vaginalis	sugar transporter, putative	0.0031	0.0201	0.0894
Loa Loa (eye worm)	major facilitator superfamily transporter	0.0031	0.0201	0.0894
Onchocerca volvulus		0.0031	0.0201	0.0285
Toxoplasma gondii	sugar transporter ST1	0.0031	0.0201	0.0305
Giardia lamblia	Sodium/hydrogen exchanger 3	0.0143	0.1436	1
Wolbachia endosymbiont of Brugia malayi	major facilitator superfamily permease	0.0031	0.0201	1
Toxoplasma gondii	sugar transporter ST2	0.0031	0.0201	0.0305
Trypanosoma brucei	glucose transporter, putative	0.0067	0.0606	0.8651
Echinococcus granulosus	mitochondrial sodium:hydrogen exchanger 9B2	0.0027	0.0165	0.0733
Chlamydia trachomatis	lysine--tRNA ligase	0.0049	0.0399	1

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

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Bibliographic References

No literature references available for this target.

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Detailed information for compound 763635