TDR Targets

Basic information

Technical information

TDR Targets ID: 763639
Name: methyl 2-[1-(4-methoxycarbonylphenyl)-3,9-dio xo-1H-chromeno[3,2-c]pyrrol-2-yl]-4-methyl-1, 3-thiazole-5-carboxylate
MW: 490.485 | Formula: C25H18N2O7S
H donors: 0 H acceptors: 5 LogP: 3.85 Rotable bonds: 6
Rule of 5 violations (Lipinski): 1
SMILES: COC(=O)c1ccc(cc1)C1N(c2sc(c(n2)C)C(=O)OC)C(=O)c2c1c(=O)c1c(o2)cccc1
InChi: 1S/C25H18N2O7S/c1-12-21(24(31)33-3)35-25(26-12)27-18(13-8-10-14(11-9-13)23(30)32-2)17-19(28)15-6-4-5-7-16(15)34-20(17)22(27)29/h4-11,18H,1-3H3
InChiKey: JMTITDAFMIJOAZ-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

methyl 2-[1-(4-methoxycarbonylphenyl)-3,9-dioxo-1H-chromeno[3,2-c]pyrrol-2-yl]-4-methyl-thiazole-5-carboxylate
2-[1-(4-methoxycarbonylphenyl)-3,9-dioxo-1H-chromeno[3,2-c]pyrrol-2-yl]-4-methyl-5-thiazolecarboxylic acid methyl ester
2-[1-(4-carbomethoxyphenyl)-3,9-diketo-1H-chromeno[3,2-c]pyrrol-2-yl]-4-methyl-thiazole-5-carboxylic acid methyl ester
NCGC00101315-01

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	thyroid hormone receptor, beta	Starlite/ChEMBL	No references
Homo sapiens	TAR DNA binding protein	Starlite/ChEMBL	No references

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Brugia malayi	TAR-binding protein	Get druggable targets OG5_132461	All targets in OG5_132461
Schistosoma japonicum	expressed protein	Get druggable targets OG5_134830	All targets in OG5_134830
Schistosoma mansoni	thyroid hormone receptor	Get druggable targets OG5_134830	All targets in OG5_134830
Brugia malayi	RNA recognition motif domain containing protein	Get druggable targets OG5_132461	All targets in OG5_132461
Schistosoma mansoni	tar DNA-binding protein	Get druggable targets OG5_132461	All targets in OG5_132461
Echinococcus granulosus	Mitotic checkpoint protein PRCC C terminal	Get druggable targets OG5_134830	All targets in OG5_134830
Schistosoma mansoni	thyroid hormone receptor	Get druggable targets OG5_134830	All targets in OG5_134830
Schistosoma mansoni	hypothetical protein	Get druggable targets OG5_134830	All targets in OG5_134830
Schistosoma japonicum	Thyroid hormone receptor alpha, putative	Get druggable targets OG5_134830	All targets in OG5_134830
Schistosoma japonicum	TAR DNA-binding protein 43, putative	Get druggable targets OG5_132461	All targets in OG5_132461
Echinococcus multilocularis	tar DNA binding protein	Get druggable targets OG5_132461	All targets in OG5_132461
Schistosoma mansoni	tar DNA-binding protein	Get druggable targets OG5_132461	All targets in OG5_132461
Schistosoma mansoni	tar DNA-binding protein	Get druggable targets OG5_132461	All targets in OG5_132461
Echinococcus multilocularis	thyroid hormone receptor alpha	Get druggable targets OG5_134830	All targets in OG5_134830
Echinococcus granulosus	tar DNA binding protein	Get druggable targets OG5_132461	All targets in OG5_132461
Schistosoma mansoni	tar DNA-binding protein	Get druggable targets OG5_132461	All targets in OG5_132461
Schistosoma japonicum	Thyroid hormone receptor alpha, putative	Get druggable targets OG5_134830	All targets in OG5_134830
Echinococcus multilocularis	Mitotic checkpoint protein PRCC, C terminal	Get druggable targets OG5_134830	All targets in OG5_134830
Brugia malayi	RNA binding protein	Get druggable targets OG5_132461	All targets in OG5_132461
Loa Loa (eye worm)	RNA binding protein	Get druggable targets OG5_132461	All targets in OG5_132461
Schistosoma japonicum	ko:K08362 nuclear receptor, subfamily 1, group A, member 2, putative	Get druggable targets OG5_134830	All targets in OG5_134830
Schistosoma mansoni	tar DNA-binding protein	Get druggable targets OG5_132461	All targets in OG5_132461
Loa Loa (eye worm)	TAR-binding protein	Get druggable targets OG5_132461	All targets in OG5_132461
Loa Loa (eye worm)	RNA recognition domain-containing protein domain-containing protein	Get druggable targets OG5_132461	All targets in OG5_132461
Schistosoma japonicum	TAR DNA-binding protein 43, putative	Get druggable targets OG5_132461	All targets in OG5_132461

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Brugia malayi	photoreceptor-specific nuclear receptor	thyroid hormone receptor, beta	461 aa	414 aa	24.6 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Toxoplasma gondii	cell-cycle-associated protein kinase MAPK, putative	0.0375	0.3734	0.5643
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0217	0.0929
Trypanosoma brucei	bifunctional aminoacyl-tRNA synthetase, putative	0.0081	0.0715	1
Echinococcus granulosus	calcium:calmodulin dependent protein kinase type	0.0071	0.0611	0.2677
Loa Loa (eye worm)	TAR-binding protein	0.0076	0.0667	0.2924
Brugia malayi	hypothetical protein	0.0033	0.0217	0.0929
Trypanosoma brucei	lysyl-tRNA synthetase, putative	0.0052	0.0414	0.5783
Onchocerca volvulus		0.0033	0.0217	1
Trypanosoma cruzi	hexose transporter, putative	0.0072	0.0621	0.868
Trichomonas vaginalis	sugar transporter, putative	0.0033	0.0217	0.0956
Trichomonas vaginalis	sugar transporter, putative	0.0033	0.0217	0.0956
Trypanosoma brucei	THT1 - hexose transporter, putative	0.0072	0.0621	0.868
Schistosoma mansoni	sugar transporter	0.0033	0.0217	0.0929
Plasmodium vivax	hexose transporter	0.0232	0.2266	0.2253
Trichomonas vaginalis	sugar transporter, putative	0.0033	0.0217	0.0956
Schistosoma mansoni	lysyl-tRNA synthetase	0.0052	0.0414	0.1801
Trichomonas vaginalis	sugar transporter, putative	0.0072	0.0621	0.274
Plasmodium vivax	proline--tRNA ligase, putative	0.0081	0.0715	0.0701
Trypanosoma cruzi	prolyl-tRNA synthetase, putative	0.0081	0.0715	1
Giardia lamblia	Lysyl-tRNA synthetase	0.0052	0.0414	0.6849
Loa Loa (eye worm)	bifunctional aminoacyl-tRNA synthetase	0.0029	0.0175	0.0745
Echinococcus granulosus	glutamyl tRNA synthetase cytoplasmic	0.007	0.0597	0.2612
Echinococcus multilocularis	calcium dependent protein kinase	0.0067	0.0566	0.2477
Schistosoma mansoni	protein kinase	0.0071	0.0611	0.2677
Trichomonas vaginalis	sugar transporter, putative	0.0033	0.0217	0.0956
Plasmodium falciparum	proline--tRNA ligase	0.0081	0.0715	0.0701
Trichomonas vaginalis	sugar transport protein, putative	0.0033	0.0217	0.0956
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0217	0.0929
Echinococcus multilocularis	solute carrier family 22	0.0033	0.0217	0.0929
Mycobacterium leprae	Probable lysyl-tRNA synthase LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase)	0.0044	0.0333	0.5587
Onchocerca volvulus		0.0033	0.0217	1
Echinococcus multilocularis	solute carrier family 2 facilitated glucose	0.0232	0.2266	1
Mycobacterium ulcerans	lysyl-tRNA synthetase	0.0052	0.0414	1
Schistosoma mansoni	nuclear transcription factor X-box binding 1 (nfx1)	0.0033	0.0217	0.0929
Trypanosoma cruzi	threonyl-tRNA synthetase, putative	0.0013	0.0016	0.0218
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0046	0.0355	0.1543
Loa Loa (eye worm)	hypothetical protein	0.0057	0.0463	0.2018
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0217	0.0929
Trichomonas vaginalis	prolyl-tRNA synthetase, putative	0.007	0.0597	0.2634
Echinococcus multilocularis	glycyl tRNA synthetase	0.0013	0.0016	0.0039
Echinococcus multilocularis	General substrate transporter	0.0199	0.193	0.8516
Trypanosoma cruzi	hexose transporter, putative	0.0039	0.0286	0.3994
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0046	0.0355	0.1543
Trichomonas vaginalis	sugar transporter, putative	0.0033	0.0217	0.0956
Echinococcus granulosus	solute carrier family 2 facilitated glucose	0.0232	0.2266	1
Echinococcus granulosus	calcium:calmodulin dependent protein kinase type	0.0071	0.0611	0.2677
Trypanosoma brucei	glucose transporter, putative	0.0072	0.0621	0.868
Leishmania major	threonyl-tRNA synthetase, putative	0.0013	0.0016	0.0218
Plasmodium falciparum	mitogen-activated protein kinase 2	0.0375	0.3734	0.3724
Echinococcus granulosus	Mitotic checkpoint protein PRCC C terminal	0.0152	0.1443	0.6359
Trichomonas vaginalis	sugar transporter, putative	0.0033	0.0217	0.0956
Echinococcus multilocularis	synaptic vesicle 2 protein	0.0033	0.0217	0.0929
Schistosoma mansoni	serine/threonine protein kinase	0.0071	0.0611	0.2677
Toxoplasma gondii	protein kinase, putative	0.0656	0.6617	1
Toxoplasma gondii	prolyl-tRNA synthetase (ProRS)	0.0081	0.0715	0.1081
Loa Loa (eye worm)	sugar transporter	0.0033	0.0217	0.0929
Plasmodium vivax	lysine--tRNA ligase, putative	0.0052	0.0414	0.0399
Brugia malayi	major facilitator superfamily protein	0.0033	0.0217	0.0929
Mycobacterium ulcerans	fusion protein of transposase for IS2606 and sialic acid-transport integral membrane protein NanT	0.0033	0.0217	0.5239
Trichomonas vaginalis	sugar transporter, putative	0.0033	0.0217	0.0956
Trypanosoma brucei	glucose transporter, putative	0.0072	0.0621	0.868
Brugia malayi	threonyl-tRNA synthetase, cytoplasmic	0.0013	0.0016	0.0039
Mycobacterium ulcerans	prolyl-tRNA synthetase	0.0025	0.0134	0.3243
Trichomonas vaginalis	sugar transporter, putative	0.0033	0.0217	0.0956
Schistosoma mansoni	protein kinase	0.0071	0.0611	0.2677
Plasmodium vivax	calcium-dependent protein kinase 3, putative	0.0071	0.0612	0.0597
Echinococcus multilocularis	calcium:calmodulin dependent protein kinase type	0.0071	0.0611	0.2677
Onchocerca volvulus		0.0033	0.0217	1
Echinococcus granulosus	calcium:calmodulin dependent protein kinase type 1	0.0071	0.0611	0.2677
Chlamydia trachomatis	lysine--tRNA ligase	0.0052	0.0414	1
Schistosoma mansoni	thyroid hormone receptor	0.0164	0.1568	0.6914
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0217	0.0929
Entamoeba histolytica	protein kinase, putative	0.0071	0.0611	1
Trichomonas vaginalis	conserved hypothetical protein	0.0033	0.0217	0.0956
Trichomonas vaginalis	conserved hypothetical protein	0.0033	0.0217	0.0956
Echinococcus multilocularis	thyroid hormone receptor alpha	0.0164	0.1568	0.6914
Trichomonas vaginalis	conserved hypothetical protein	0.0033	0.0217	0.0956
Leishmania major	hypothetical protein, conserved	0.0033	0.0217	0.303
Trichomonas vaginalis	CAMK family protein kinase	0.0071	0.0611	0.2699
Mycobacterium ulcerans	sugar-transport integral membrane protein SugI	0.0033	0.0217	0.5239
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0217	0.0929
Leishmania major	lysyl-tRNA synthetase, putative	0.0052	0.0414	0.5783
Echinococcus granulosus	Sugar transporter ERD6 protein	0.0033	0.0217	0.0929
Onchocerca volvulus		0.0033	0.0217	1
Plasmodium falciparum	calcium-dependent protein kinase 5	0.0071	0.0612	0.0597
Trichomonas vaginalis	sugar transporter, putative	0.0033	0.0217	0.0956
Onchocerca volvulus		0.0033	0.0217	1
Trichomonas vaginalis	conserved hypothetical protein	0.0072	0.0621	0.274
Toxoplasma gondii	lysine-tRNA ligase	0.0052	0.0414	0.0625
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0217	0.0929
Brugia malayi	RNA recognition motif domain containing protein	0.0076	0.0667	0.2924
Chlamydia trachomatis	proline--tRNA ligase	0.0025	0.0134	0.2978
Schistosoma mansoni	tar DNA-binding protein	0.0076	0.0667	0.2924
Echinococcus multilocularis	solute carrier family 22	0.0033	0.0217	0.0929
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0217	0.0929
Onchocerca volvulus		0.0033	0.0217	1
Toxoplasma gondii	sugar transporter ST2	0.0033	0.0217	0.0327
Trypanosoma brucei	glucose transporter, putative	0.0072	0.0621	0.868
Loa Loa (eye worm)	hypothetical protein	0.007	0.0597	0.2612
Echinococcus multilocularis	calcium:calmodulin dependent protein kinase type	0.0071	0.0611	0.2677
Plasmodium falciparum	calcium-dependent protein kinase 4	0.0071	0.0612	0.0597
Trypanosoma cruzi	threonyl-tRNA synthetase, putative	0.0013	0.0016	0.0218
Echinococcus granulosus	General substrate transporter	0.0199	0.193	0.8516
Trichomonas vaginalis	glucose transporter, putative	0.0072	0.0621	0.274
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0217	0.0929
Plasmodium vivax	CDK-related protein kinase 6, putative	0.0985	1	1
Onchocerca volvulus		0.0033	0.0217	1
Schistosoma mansoni	glucose transporter	0.0033	0.0217	0.0929
Schistosoma mansoni	thyroid hormone receptor	0.0164	0.1568	0.6914
Loa Loa (eye worm)	major facilitator superfamily transporter	0.0033	0.0217	0.0929
Loa Loa (eye worm)	sugar transporter	0.0232	0.2266	1
Trypanosoma cruzi	sugar transporter, putative	0.0033	0.0217	0.303
Plasmodium vivax	sugar transporter, putative	0.0033	0.0217	0.0201
Trichomonas vaginalis	sugar transporter, putative	0.0033	0.0217	0.0956
Echinococcus multilocularis	calcium:calmodulin dependent protein kinase type	0.0071	0.0611	0.2677
Echinococcus granulosus	calcium dependent protein kinase	0.0067	0.0566	0.2477
Mycobacterium tuberculosis	Probable conserved integral membrane transport protein	0.0033	0.0217	0.6499
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0217	0.0929
Trichomonas vaginalis	sugar transporter, putative	0.0033	0.0217	0.0956
Trichomonas vaginalis	sugar transporter, putative	0.0033	0.0217	0.0956
Leishmania major	myo-inositol/proton symporter (MIT)	0.0033	0.0217	0.303
Echinococcus granulosus	solute carrier family 2 facilitated glucose	0.0232	0.2266	1
Echinococcus multilocularis	lysyl tRNA synthetase	0.0052	0.0414	0.1801
Toxoplasma gondii	transporter, major facilitator family protein	0.0033	0.0217	0.0327
Plasmodium vivax	mitogen-activated protein kinase 2, putative	0.0375	0.3734	0.3724
Echinococcus multilocularis	Sugar transporter ERD6 protein	0.0033	0.0217	0.0929
Mycobacterium tuberculosis	Lysyl-tRNA synthetase 2 LysX	0.0044	0.0333	1
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0046	0.0355	0.1543
Brugia malayi	probable proline-trna synthetase - fission yeast, putative	0.0013	0.0016	0.0039
Schistosoma mansoni	sugar transporter	0.0033	0.0217	0.0929
Trichomonas vaginalis	sugar transporter, putative	0.0033	0.0217	0.0956
Brugia malayi	Major Facilitator Superfamily protein	0.0033	0.0217	0.0929
Echinococcus multilocularis	Threonyl tRNA synthetase, C	0.0013	0.0016	0.0039
Schistosoma mansoni	glucose transport protein	0.0232	0.2266	1
Trichomonas vaginalis	sugar transporter, putative	0.0033	0.0217	0.0956
Loa Loa (eye worm)	glycyl-tRNA synthetase	0.0013	0.0016	0.0039
Trypanosoma brucei	myo-inositol/proton symporter (MIT)	0.0033	0.0217	0.303
Trypanosoma brucei	glucose transporter, putative	0.0072	0.0621	0.868
Leishmania major	glucose transporter/membrane transporter D2, putative	0.0072	0.0621	0.868
Schistosoma mansoni	protein kinase	0.0071	0.0611	0.2677
Trichomonas vaginalis	sugar transporter, putative	0.0033	0.0217	0.0956
Leishmania major	glucose transporter, lmgt1	0.0072	0.0621	0.868
Loa Loa (eye worm)	hypothetical protein	0.0013	0.0016	0.0039
Mycobacterium ulcerans	threonyl-tRNA synthetase	0.0013	0.0016	0.0377
Onchocerca volvulus		0.0033	0.0217	1
Trichomonas vaginalis	threonyl-tRNA synthetase, putative	0.0013	0.0016	0.0069
Plasmodium falciparum	hexose transporter	0.0232	0.2266	0.2253
Trichomonas vaginalis	sugar transporter, putative	0.0033	0.0217	0.0956
Echinococcus granulosus	glycyl tRNA synthetase	0.0013	0.0016	0.0039
Echinococcus granulosus	solute carrier family 2 facilitated glucose	0.0232	0.2266	1
Brugia malayi	Bifunctional aminoacyl-tRNA synthetase	0.007	0.0597	0.2612
Loa Loa (eye worm)	RNA binding protein	0.0076	0.0667	0.2924
Trichomonas vaginalis	lysyl-tRNA synthetase, putative	0.0045	0.0348	0.1536
Echinococcus granulosus	Threonyl tRNA synthetase C	0.0013	0.0016	0.0039
Schistosoma mansoni	glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs)	0.007	0.0597	0.2612
Loa Loa (eye worm)	hypothetical protein	0.0071	0.0611	0.2677
Trypanosoma cruzi	hexose transporter, putative	0.0033	0.0217	0.303
Trichomonas vaginalis	sugar transporter, putative	0.0033	0.0217	0.0956
Trichomonas vaginalis	sugar transporter, putative	0.0033	0.0217	0.0956
Onchocerca volvulus		0.0033	0.0217	1
Wolbachia endosymbiont of Brugia malayi	major facilitator superfamily permease	0.0033	0.0217	1
Trichomonas vaginalis	sugar transporter, putative	0.0033	0.0217	0.0956
Plasmodium falciparum	calcium-dependent protein kinase 1	0.0071	0.0612	0.0597
Schistosoma mansoni	tar DNA-binding protein	0.0076	0.0667	0.2924
Echinococcus multilocularis	solute carrier family 2 facilitated glucose	0.0232	0.2266	1
Trichomonas vaginalis	sugar transporter, putative	0.0033	0.0217	0.0956
Loa Loa (eye worm)	calcium/calmodulin-dependent protein kinase ID	0.0071	0.0611	0.2677
Echinococcus multilocularis	calcium:calmodulin dependent protein kinase type	0.0071	0.0611	0.2677
Brugia malayi	Calcium/calmodulin-dependent protein kinase type II alpha chain	0.0071	0.0611	0.2677
Schistosoma mansoni	hypothetical protein	0.0152	0.1443	0.6359
Trypanosoma brucei	glucose transporter, putative	0.0072	0.0621	0.868
Plasmodium falciparum	calcium-dependent protein kinase 3	0.0071	0.0612	0.0597
Leishmania major	glucose transporter, lmgt2	0.0072	0.0621	0.868
Loa Loa (eye worm)	hypothetical protein	0.007	0.0597	0.2612
Mycobacterium leprae	Probable threonyl-tRNA synthetase ThrS (threonine-tRNA synthetase) (ThrRS) (Threonine-tRNA ligase)	0.0013	0.0016	0.0262
Echinococcus multilocularis	Mitotic checkpoint protein PRCC, C terminal	0.0152	0.1443	0.6359
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0217	0.0929
Trichomonas vaginalis	sugar transporter, putative	0.0033	0.0217	0.0956
Mycobacterium ulcerans	sugar transporter	0.0033	0.0217	0.5239
Toxoplasma gondii	sugar transporter ST3	0.0033	0.0217	0.0327
Schistosoma mansoni	lysyl-tRNA synthetase	0.0052	0.0414	0.1801
Trichomonas vaginalis	conserved hypothetical protein	0.0232	0.2266	1
Trypanosoma cruzi	hexose transporter	0.0072	0.0621	0.868
Entamoeba histolytica	protein kinase, putative	0.0071	0.0611	1
Trypanosoma brucei	calcium/calmodulin-dependent protein kinase, putative	0.0071	0.0611	0.855
Brugia malayi	hypothetical protein	0.0033	0.0217	0.0929
Brugia malayi	Sugar transporter family protein	0.0232	0.2266	1
Plasmodium vivax	calcium-dependent protein kinase 4, putative	0.0071	0.0612	0.0597
Trypanosoma brucei	glucose transporter, putative	0.0072	0.0621	0.868
Onchocerca volvulus		0.0033	0.0217	1
Trichomonas vaginalis	glucose transporter, putative	0.0033	0.0217	0.0956
Trichomonas vaginalis	sugar transporter, putative	0.0033	0.0217	0.0956
Echinococcus granulosus	solute carrier family 22	0.0033	0.0217	0.0929
Leishmania major	prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative	0.0081	0.0715	1
Loa Loa (eye worm)	hypothetical protein	0.0052	0.0414	0.1801
Trichomonas vaginalis	sugar transporter, putative	0.0033	0.0217	0.0956
Trypanosoma cruzi	prolyl-tRNA synthetase, putative	0.0081	0.0715	1
Trichomonas vaginalis	sugar transporter, putative	0.0033	0.0217	0.0956
Onchocerca volvulus		0.0033	0.0217	1
Toxoplasma gondii	glycyl-tRNA synthetase	0.0013	0.0016	0.0024
Echinococcus multilocularis	solute carrier family 2 facilitated glucose	0.0232	0.2266	1
Toxoplasma gondii	facilitative glucose transporter GT1	0.0232	0.2266	0.3424
Schistosoma mansoni	glycyl-tRNA synthetase	0.0013	0.0016	0.0039
Brugia malayi	RNA binding protein	0.0076	0.0667	0.2924
Trypanosoma brucei	glucose transporter, putative	0.0072	0.0621	0.868
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0217	0.0929
Onchocerca volvulus		0.0033	0.0217	1
Echinococcus granulosus	tar DNA binding protein	0.0076	0.0667	0.2924
Trichomonas vaginalis	conserved hypothetical protein	0.0072	0.0621	0.274
Loa Loa (eye worm)	RNA recognition domain-containing protein domain-containing protein	0.0076	0.0667	0.2924
Plasmodium falciparum	protein kinase 7	0.0656	0.6617	0.6612
Echinococcus granulosus	solute carrier family 2 facilitated glucose	0.0232	0.2266	1
Schistosoma mansoni	glucose transport protein	0.0232	0.2266	1
Leishmania major	glucose transporter, lmgt3	0.0072	0.0621	0.868
Trypanosoma brucei	glucose transporter 2A	0.0072	0.0621	0.868
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0046	0.0355	0.1543
Echinococcus multilocularis	solute carrier family 22	0.0033	0.0217	0.0929
Trypanosoma cruzi	hexose transporter, putative	0.0072	0.0621	0.868
Trichomonas vaginalis	conserved hypothetical protein	0.0033	0.0217	0.0956
Echinococcus multilocularis	glutamyl tRNA synthetase cytoplasmic	0.007	0.0597	0.2612
Trypanosoma cruzi	glucose transporter, putative	0.0033	0.0217	0.303
Echinococcus granulosus	solute carrier family 22	0.0033	0.0217	0.0929
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0046	0.0355	0.1543
Brugia malayi	lysyl-tRNA synthetase	0.0052	0.0414	0.1801
Schistosoma mansoni	glucose transport protein	0.0232	0.2266	1
Trichomonas vaginalis	sugar transporter, putative	0.0072	0.0621	0.274
Echinococcus granulosus	solute carrier family 22	0.0033	0.0217	0.0929
Onchocerca volvulus		0.0033	0.0217	1
Trypanosoma cruzi	lysyl-tRNA synthetase, putative	0.0052	0.0414	0.5783
Plasmodium vivax	calcium-dependent protein kinase, putative	0.0071	0.0612	0.0597
Trypanosoma brucei	glucose transporter 1E	0.0072	0.0621	0.868
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0046	0.0355	0.1543
Brugia malayi	hypothetical protein	0.0033	0.0217	0.0929
Brugia malayi	Cam kinase protein 1	0.0071	0.0611	0.2677
Echinococcus granulosus	lysyl tRNA synthetase	0.0052	0.0414	0.1801
Trichomonas vaginalis	sugar transporter, putative	0.0033	0.0217	0.0956
Leishmania major	protein kinase, putative	0.0071	0.0611	0.855
Toxoplasma gondii	calcium-dependent protein kinase CDPK2A	0.0071	0.0612	0.0925
Trichomonas vaginalis	sugar transporter, putative	0.0033	0.0217	0.0956
Entamoeba histolytica	hypothetical protein	0.0052	0.0414	0.6679
Giardia lamblia	Prolyl-tRNA synthetase	0.007	0.0597	1
Loa Loa (eye worm)	threonyl-tRNA synthetase	0.0013	0.0016	0.0039
Plasmodium falciparum	lysine--tRNA ligase	0.0052	0.0414	0.0399
Brugia malayi	glycyl-tRNA synthetase	0.0013	0.0016	0.0039
Toxoplasma gondii	sugar transporter ST1	0.0033	0.0217	0.0327
Toxoplasma gondii	calcium-dependent protein kinase CDPK3	0.0071	0.0612	0.0925
Brugia malayi	Sugar transporter family protein	0.0033	0.0217	0.0929
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0046	0.0355	0.1543
Trypanosoma brucei	glucose transporter, putative	0.0072	0.0621	0.868
Trichomonas vaginalis	sugar transporter, putative	0.0033	0.0217	0.0956
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0217	0.0929
Echinococcus multilocularis	tar DNA binding protein	0.0076	0.0667	0.2924
Brugia malayi	Sugar transporter family protein	0.0033	0.0217	0.0929
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0217	0.0929
Mycobacterium tuberculosis	Probable dicarboxylic acid transport integral membrane protein KgtP (dicarboxylate transporter)	0.0033	0.0217	0.6499
Trichomonas vaginalis	sugar transporter, putative	0.0033	0.0217	0.0956
Toxoplasma gondii	calcium-dependent protein kinase CDPK2B	0.0071	0.0612	0.0925
Trypanosoma brucei	threonyl-tRNA synthetase, putative	0.0013	0.0016	0.0218
Echinococcus granulosus	calcium:calmodulin dependent protein kinase type	0.0071	0.0611	0.2677
Onchocerca volvulus	Putative transporter	0.0033	0.0217	1
Schistosoma mansoni	sugar transporter	0.0033	0.0217	0.0929
Mycobacterium leprae	Possible lysyl-tRNA synthetase 2 LysX	0.0052	0.0414	0.6932
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0046	0.0355	0.1543
Onchocerca volvulus		0.0033	0.0217	1
Schistosoma mansoni	hypothetical protein	0.0232	0.2266	1
Loa Loa (eye worm)	CAMK/CAMK2 protein kinase	0.0071	0.0611	0.2677
Trypanosoma cruzi	hexose transporter, putative	0.0072	0.0621	0.868
Mycobacterium tuberculosis	Lysyl-tRNA synthetase 1 LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase)	0.0044	0.0333	1
Echinococcus granulosus	solute carrier family 22	0.0033	0.0217	0.0929
Mycobacterium tuberculosis	Probable threonyl-tRNA synthetase ThrS (threonine-tRNA synthetase)(ThrRS) (threonine-tRNA ligase)	0.0013	0.0016	0.0468
Onchocerca volvulus		0.0033	0.0217	1
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0217	0.0929
Brugia malayi	bifunctional aminoacyl-tRNA synthetase	0.007	0.0597	0.2612
Brugia malayi	TAR-binding protein	0.0076	0.0667	0.2924
Brugia malayi	Major Facilitator Superfamily protein	0.0033	0.0217	0.0929
Plasmodium falciparum	major facilitator superfamily domain-containing protein, putative	0.0033	0.0217	0.0201
Trichomonas vaginalis	sugar transporter, putative	0.0033	0.0217	0.0956
Mycobacterium leprae	Probable prolyl tRNA synthetase ProS	0.007	0.0597	1
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0217	0.0929
Trypanosoma brucei	THT1 - hexose transporter, putative	0.0072	0.0621	0.868
Trypanosoma brucei	THT1 - hexose transporter, putative	0.0072	0.0621	0.868
Entamoeba histolytica	prolyl-tRNA synthetase, putative	0.007	0.0597	0.9752
Toxoplasma gondii	threonyl-tRNA synthetase family protein	0.0013	0.0016	0.0024
Treponema pallidum	prolyl-tRNA synthetase	0.0025	0.0134	1
Schistosoma mansoni	glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs)	0.007	0.0597	0.2612
Trichomonas vaginalis	sugar transporter, putative	0.0033	0.0217	0.0956
Schistosoma mansoni	sugar transporter	0.0033	0.0217	0.0929
Leishmania major	prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative	0.0081	0.0715	1
Trichomonas vaginalis	sugar transporter, putative	0.0033	0.0217	0.0956
Echinococcus granulosus	synaptic vesicle 2 protein	0.0033	0.0217	0.0929
Trichomonas vaginalis	glucose transporter, putative	0.0072	0.0621	0.274
Echinococcus multilocularis	solute carrier family 22	0.0033	0.0217	0.0929
Trichomonas vaginalis	conserved hypothetical protein	0.0033	0.0217	0.0956
Trypanosoma brucei	glycyl-tRNA synthetase, putative	0.0013	0.0016	0.0218
Mycobacterium ulcerans	integral membrane transport protein	0.0033	0.0217	0.5239
Trichomonas vaginalis	myo-inositol transporter, putative	0.0033	0.0217	0.0956
Trypanosoma brucei	sugar transporter, putative	0.0033	0.0217	0.303
Trichomonas vaginalis	sugar transporter, putative	0.0033	0.0217	0.0956
Mycobacterium ulcerans	lysyl-tRNA synthetase	0.0052	0.0414	1
Brugia malayi	Major Facilitator Superfamily protein	0.0033	0.0217	0.0929
Giardia lamblia	Sugar-proton symporter	0.0033	0.0217	0.346
Brugia malayi	major facilitator superfamily protein	0.0033	0.0217	0.0929
Schistosoma mansoni	tar DNA-binding protein	0.0076	0.0667	0.2924
Onchocerca volvulus		0.0033	0.0217	1
Giardia lamblia	Hexose transporter	0.0033	0.0217	0.346
Plasmodium falciparum	calcium-dependent protein kinase 2	0.0071	0.0612	0.0597
Trichomonas vaginalis	lysyl-tRNA synthetase, putative	0.0052	0.0414	0.1826
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0046	0.0355	0.1543
Trichomonas vaginalis	sugar transporter, putative	0.0033	0.0217	0.0956
Trichomonas vaginalis	sugar transporter, putative	0.0033	0.0217	0.0956
Loa Loa (eye worm)	major facilitator superfamily transporter	0.0033	0.0217	0.0929
Echinococcus multilocularis	solute carrier family 2, facilitated glucose	0.0232	0.2266	1
Schistosoma mansoni	tar DNA-binding protein	0.0076	0.0667	0.2924
Trichomonas vaginalis	sugar transporter, putative	0.0072	0.0621	0.274
Mycobacterium ulcerans	glycyl-tRNA synthetase	0.0013	0.0016	0.0377
Plasmodium vivax	calcium-dependent protein kinase 1, putative	0.0071	0.0612	0.0597
Schistosoma mansoni	tar DNA-binding protein	0.0076	0.0667	0.2924
Trichomonas vaginalis	sugar transporter, putative	0.0033	0.0217	0.0956

Activities

Activity type	Activity value	Assay description	Source	Reference
Potency (functional)	= 0.1 um	PUBCHEM_BIOASSAY: Total Fluorescence Counterscreen for Inhibitors of the Interaction of Thyroid Hormone Receptor and Steroid Receptor Coregulator 2. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	6.3096 uM	PubChem BioAssay. qHTS of TDP-43 Inhibitors. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	31.6228 uM	PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404]	ChEMBL.	No reference
Potency (functional)	39.8107 uM	PubChem BioAssay. qHTS of PTHR Inhibitors: Primary Screen. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	89.1251 uM	PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623]	ChEMBL.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1358760
Search by Saint Jude

Bibliographic References

No literature references available for this target.

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Detailed information for compound 763639