TDR Targets

Basic information

Technical information

TDR Targets ID: 763654
Name: (E)-3-[2-(4-tert-butylphenoxy)-4-oxopyrido[1, 2-a]pyrimidin-3-yl]-2-cyano-N-(furan-2-ylmeth yl)prop-2-enamide
MW: 468.504 | Formula: C27H24N4O4
H donors: 1 H acceptors: 3 LogP: 3.77 Rotable bonds: 8
Rule of 5 violations (Lipinski): 1
SMILES: N#CC(=Cc1c(Oc2ccc(cc2)C(C)(C)C)nc2n(c1=O)cccc2)C(=O)NCc1ccco1
InChi: 1S/C27H24N4O4/c1-27(2,3)19-9-11-20(12-10-19)35-25-22(26(33)31-13-5-4-8-23(31)30-25)15-18(16-28)24(32)29-17-21-7-6-14-34-21/h4-15H,17H2,1-3H3,(H,29,32)/b18-15+
InChiKey: DYUGQKMOYXYQGE-OBGWFSINSA-N

Network

Hover on a compound node to display the structore

Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

This is a work in progress. Come back soon to try this features!

Clustering layers

This is a work in progress. Come back soon to try this features!

Synonyms

3-[2-(4-tert-butylphenoxy)-4-oxopyrido[1,2-a]pyrimidin-3-yl]-2-cyano-N-(furan-2-ylmethyl)prop-2-enamide
(E)-3-[2-(4-tert-butylphenoxy)-4-oxo-pyrido[1,2-a]pyrimidin-3-yl]-2-cyano-N-(2-furylmethyl)prop-2-enamide
3-[2-(4-tert-butylphenoxy)-4-oxo-pyrido[1,2-a]pyrimidin-3-yl]-2-cyano-N-(2-furylmethyl)prop-2-enamide
3-[2-(4-tert-butylphenoxy)-4-oxo-3-pyrido[1,2-a]pyrimidinyl]-2-cyano-N-(2-furylmethyl)prop-2-enamide
(E)-3-[2-(4-tert-butylphenoxy)-4-oxo-3-pyrido[1,2-a]pyrimidinyl]-2-cyano-N-(2-furylmethyl)prop-2-enamide
3-[2-(4-tert-butylphenoxy)-4-keto-pyrido[1,2-a]pyrimidin-3-yl]-2-cyano-N-(2-furylmethyl)acrylamide
(E)-3-[2-(4-tert-butylphenoxy)-4-keto-pyrido[1,2-a]pyrimidin-3-yl]-2-cyano-N-(2-furylmethyl)acrylamide
3-[2-(4-tert-butylphenoxy)-4-oxo-pyrido[1,2-a]pyrimidin-3-yl]-2-cyano-N-(furan-2-ylmethyl)prop-2-enamide
(E)-3-[2-(4-tert-butylphenoxy)-4-oxo-pyrido[1,2-a]pyrimidin-3-yl]-2-cyano-N-(furan-2-ylmethyl)prop-2-enamide
STOCK4S-34760

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus granulosus	solute carrier family 22	0.0031	0.0201	0.0529
Echinococcus granulosus	Sugar transporter ERD6 protein	0.0031	0.0201	0.0529
Treponema pallidum	exodeoxyribonuclease (exoA)	0.0021	0.0097	0.814
Trypanosoma cruzi	hexose transporter	0.0067	0.0606	0.8651
Mycobacterium tuberculosis	Probable dicarboxylic acid transport integral membrane protein KgtP (dicarboxylate transporter)	0.0031	0.0201	0.6328
Trichomonas vaginalis	Clan SC, family S28, unassigned serine peptidase	0.0019	0.0077	0.0279
Echinococcus granulosus	solute carrier family 22	0.0031	0.0201	0.0529
Echinococcus granulosus	solute carrier family 2 facilitated glucose	0.0218	0.2253	0.5919
Trichomonas vaginalis	Clan SC, family S28, unassigned serine peptidase	0.0019	0.0077	0.0279
Plasmodium falciparum	lysine--tRNA ligase	0.0049	0.0399	0.0399
Echinococcus granulosus	Lysosomal Pro X carboxypeptidase	0.0359	0.3807	1
Trichomonas vaginalis	ap endonuclease, putative	0.0021	0.0097	0.0348
Toxoplasma gondii	prolyl-tRNA synthetase (ProRS)	0.0076	0.0701	0.106
Plasmodium falciparum	calcium-dependent protein kinase 4	0.0067	0.0597	0.0597
Entamoeba histolytica	protein kinase, putative	0.0067	0.0597	1
Trichomonas vaginalis	sugar transporter, putative	0.0031	0.0201	0.0726
Trichomonas vaginalis	sugar transporter, putative	0.0031	0.0201	0.0726
Echinococcus granulosus	lysyl tRNA synthetase	0.0049	0.0399	0.1047
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0033	0.0232	0.061
Plasmodium vivax	calcium-dependent protein kinase, putative	0.0067	0.0597	0.0597
Mycobacterium tuberculosis	Probable protease II PtrBb [second part] (oligopeptidase B)	0.0013	0.0009	0.0278
Entamoeba histolytica	dipeptidyl-peptidase, putative	0.0013	0.0009	0.0149
Brugia malayi	Serine carboxypeptidase S28 family protein	0.0019	0.0077	0.032
Trichomonas vaginalis	sugar transporter, putative	0.0067	0.0606	0.2185
Echinococcus multilocularis	General substrate transporter	0.0187	0.1918	0.5038
Echinococcus granulosus	solute carrier family 22	0.0031	0.0201	0.0529
Onchocerca volvulus		0.0031	0.0201	0.0696
Trichomonas vaginalis	sugar transporter, putative	0.0031	0.0201	0.0726
Schistosoma mansoni	hypothetical protein	0.0036	0.0263	0.0691
Trypanosoma brucei	serine peptidase, clan SC, family S9A-like protein	0.0013	0.0009	0.0126
Entamoeba histolytica	hypothetical protein	0.0036	0.0263	0.4407
Echinococcus multilocularis	dipeptidyl aminopeptidaseprotein	0.0165	0.1672	0.4393
Schistosoma mansoni	protein kinase	0.0067	0.0597	0.1568
Trypanosoma cruzi	serine peptidase, Clan SC, Family S9B	0.0055	0.0473	0.6752
Schistosoma mansoni	subfamily S9B unassigned peptidase (S09 family)	0.0165	0.1672	0.4393
Schistosoma mansoni	sugar transporter	0.0031	0.0201	0.0529
Brugia malayi	prolyl oligopeptidase family protein	0.0055	0.0473	0.1954
Loa Loa (eye worm)	hypothetical protein	0.0065	0.0582	0.2404
Trichomonas vaginalis	Clan SC, family S28, unassigned serine peptidase	0.0019	0.0077	0.0279
Trypanosoma cruzi	oligopeptidase b	0.0013	0.0009	0.0126
Wolbachia endosymbiont of Brugia malayi	exonuclease III	0.0021	0.0097	0.4797
Schistosoma mansoni	glucose transport protein	0.0218	0.2253	0.5919
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0036	0.0263	0.0691
Loa Loa (eye worm)	exodeoxyribonuclease III family protein	0.0021	0.0097	0.0399
Trichomonas vaginalis	lysyl-tRNA synthetase, putative	0.0043	0.0333	0.12
Trichomonas vaginalis	myo-inositol transporter, putative	0.0031	0.0201	0.0726
Trichomonas vaginalis	set domain proteins, putative	0.0265	0.2775	1
Plasmodium falciparum	calcium-dependent protein kinase 3	0.0067	0.0597	0.0597
Echinococcus multilocularis	Lysosomal Pro X carboxypeptidase	0.0359	0.3807	1
Schistosoma mansoni	hypothetical protein	0.0218	0.2253	0.5919
Schistosoma mansoni	nuclear transcription factor X-box binding 1 (nfx1)	0.0031	0.0201	0.0529
Echinococcus granulosus	calcium:calmodulin dependent protein kinase type	0.0067	0.0597	0.1568
Trichomonas vaginalis	sugar transporter, putative	0.0031	0.0201	0.0726
Onchocerca volvulus		0.0031	0.0201	0.0696
Echinococcus granulosus	solute carrier family 2 facilitated glucose	0.0218	0.2253	0.5919
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0077	0.032
Trichomonas vaginalis	sugar transporter, putative	0.0031	0.0201	0.0726
Onchocerca volvulus		0.0019	0.0077	0.0248
Mycobacterium ulcerans	lysyl-tRNA synthetase	0.0049	0.0399	1
Trichomonas vaginalis	Clan SC, family S28, unassigned serine peptidase	0.0019	0.0077	0.0279
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0201	0.0832
Leishmania major	oligopeptidase b	0.0013	0.0009	0.0126
Schistosoma mansoni	sugar transporter	0.0031	0.0201	0.0529
Trypanosoma brucei	prolyl oligopeptidase, putative	0.0013	0.0009	0.0126
Brugia malayi	hypothetical protein	0.0042	0.033	0.1362
Trypanosoma brucei	serine peptidase, Clan SC, Family S9B	0.0055	0.0473	0.6752
Trichomonas vaginalis	sugar transporter, putative	0.0031	0.0201	0.0726
Leishmania major	dipeptidyl-peptidase 8-like serine peptidase, putative,serine peptidase, Clan SC, Family S9B	0.0055	0.0473	0.6752
Schistosoma mansoni	prolyl oligopeptidase (S09 family)	0.0013	0.0009	0.0023
Trypanosoma cruzi	oligopeptidase B-like protein, putative	0.0013	0.0009	0.0126
Brugia malayi	hypothetical protein	0.0031	0.0201	0.0832
Onchocerca volvulus		0.0031	0.0201	0.0696
Onchocerca volvulus		0.0033	0.0232	0.0808
Entamoeba histolytica	prolyl oligopeptidase family protein	0.0013	0.0009	0.0149
Plasmodium falciparum	calcium-dependent protein kinase 2	0.0067	0.0597	0.0597
Echinococcus multilocularis	Lysosomal Pro X carboxypeptidase	0.0019	0.0077	0.0203
Trypanosoma brucei	apurinic/apyrimidinic endonuclease, putative	0.0021	0.0097	0.1379
Trichomonas vaginalis	Clan SC, family S28, unassigned serine peptidase	0.0019	0.0077	0.0279
Leishmania major	glucose transporter/membrane transporter D2, putative	0.0067	0.0606	0.8651
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0077	0.032
Trichomonas vaginalis	prolylcarboxypeptidase, putative	0.0019	0.0077	0.0279
Plasmodium falciparum	protein kinase 7	0.0615	0.6612	0.6612
Echinococcus granulosus	dipeptidyl aminopeptidaseprotein	0.0165	0.1672	0.4393
Trichomonas vaginalis	sugar transporter, putative	0.0031	0.0201	0.0726
Echinococcus multilocularis	lysyl tRNA synthetase	0.0049	0.0399	0.1047
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0201	0.0832
Entamoeba histolytica	hypothetical protein	0.0049	0.0399	0.6679
Echinococcus multilocularis	acylamino acid releasing enzyme	0.0013	0.0009	0.0023
Schistosoma mansoni	glucose transport protein	0.0218	0.2253	0.5919
Trypanosoma cruzi	hypothetical protein, conserved	0.0013	0.0009	0.0127
Trypanosoma cruzi	putative prolyl carboxypeptidase, putative	0.0019	0.0077	0.1105
Leishmania major	glucose transporter, lmgt3	0.0067	0.0606	0.8651
Trypanosoma cruzi	glucose transporter, putative	0.0031	0.0201	0.2874
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0201	0.0832
Echinococcus multilocularis	solute carrier family 2, facilitated glucose	0.0218	0.2253	0.5919
Onchocerca volvulus		0.0031	0.0201	0.0696
Brugia malayi	hypothetical protein	0.0031	0.0201	0.0832
Trichomonas vaginalis	sugar transporter, putative	0.0031	0.0201	0.0726
Trypanosoma cruzi	hexose transporter, putative	0.0067	0.0606	0.8651
Entamoeba histolytica	hypothetical protein	0.0036	0.0263	0.4407
Trichomonas vaginalis	sugar transporter, putative	0.0031	0.0201	0.0726
Loa Loa (eye worm)	hypothetical protein	0.0013	0.0009	0.0037
Plasmodium vivax	SET domain protein, putative	0.0033	0.0232	0.0232
Onchocerca volvulus		0.0031	0.0201	0.0696
Leishmania major	glucose transporter, lmgt2	0.0067	0.0606	0.8651
Loa Loa (eye worm)	calcium/calmodulin-dependent protein kinase ID	0.0067	0.0597	0.2465
Loa Loa (eye worm)	hypothetical protein	0.0065	0.0582	0.2404
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0201	0.0832
Plasmodium falciparum	calcium-dependent protein kinase 1	0.0067	0.0597	0.0597
Leishmania major	myo-inositol/proton symporter (MIT)	0.0031	0.0201	0.2874
Trichomonas vaginalis	conserved hypothetical protein	0.0031	0.0201	0.0726
Brugia malayi	Pre-SET motif family protein	0.0033	0.0232	0.0959
Loa Loa (eye worm)	hypothetical protein	0.0013	0.0009	0.0037
Trypanosoma brucei	glucose transporter, putative	0.0067	0.0606	0.8651
Echinococcus multilocularis	Dipeptidyl peptidase 9	0.0055	0.0473	0.1243
Trypanosoma cruzi	hexose transporter, putative	0.0067	0.0606	0.8651
Brugia malayi	Bifunctional aminoacyl-tRNA synthetase	0.0065	0.0582	0.2404
Trichomonas vaginalis	sugar transporter, putative	0.0031	0.0201	0.0726
Echinococcus granulosus	prolyl endopeptidase	0.0013	0.0009	0.0023
Trichomonas vaginalis	lysosomal pro-X carboxypeptidase, putative	0.0019	0.0077	0.0279
Trichomonas vaginalis	Clan SC, family S28, unassigned serine peptidase	0.0019	0.0077	0.0279
Mycobacterium leprae	Possible lysyl-tRNA synthetase 2 LysX	0.0049	0.0399	0.6849
Toxoplasma gondii	hypothetical protein	0.0013	0.0009	0.0013
Trichomonas vaginalis	sugar transporter, putative	0.0031	0.0201	0.0726
Giardia lamblia	Prolyl-tRNA synthetase	0.0065	0.0582	1
Trichomonas vaginalis	Clan SC, family S28, unassigned serine peptidase	0.0019	0.0077	0.0279
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0201	0.0832
Schistosoma mansoni	ap endonuclease	0.0021	0.0097	0.0254
Toxoplasma gondii	sugar transporter ST3	0.0031	0.0201	0.0305
Wolbachia endosymbiont of Brugia malayi	major facilitator superfamily permease	0.0031	0.0201	1
Echinococcus multilocularis	prolyl endopeptidase	0.0013	0.0009	0.0023
Trichomonas vaginalis	sugar transporter, putative	0.0031	0.0201	0.0726
Toxoplasma gondii	calcium-dependent protein kinase CDPK2B	0.0067	0.0597	0.0903
Toxoplasma gondii	lysine-tRNA ligase	0.0049	0.0399	0.0603
Schistosoma mansoni	serine/threonine protein kinase	0.0067	0.0597	0.1568
Brugia malayi	Cam kinase protein 1	0.0067	0.0597	0.2465
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0033	0.0232	0.061
Trichomonas vaginalis	sugar transporter, putative	0.0031	0.0201	0.0726
Toxoplasma gondii	dipeptidyl peptidase iv (dpp iv) n-terminal region domain-containing protein	0.0055	0.0473	0.0716
Echinococcus multilocularis	calcium:calmodulin dependent protein kinase type	0.0067	0.0597	0.1568
Entamoeba histolytica	prolyl oligopeptidase family protein	0.0013	0.0009	0.0149
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0201	0.0832
Trichomonas vaginalis	sugar transporter, putative	0.0031	0.0201	0.0726
Onchocerca volvulus		0.0031	0.0201	0.0696
Mycobacterium ulcerans	sugar transporter	0.0031	0.0201	0.5052
Entamoeba histolytica	serine carboxypeptidase (S28) family protein	0.0019	0.0077	0.1298
Onchocerca volvulus		0.0031	0.0201	0.0696
Onchocerca volvulus		0.0265	0.2775	1
Trichomonas vaginalis	Clan SC, family S28, unassigned serine peptidase	0.0019	0.0077	0.0279
Entamoeba histolytica	serine carboxypeptidase (S28) family protein	0.0019	0.0077	0.1298
Trichomonas vaginalis	sugar transporter, putative	0.0031	0.0201	0.0726
Brugia malayi	prolyl oligopeptidase family protein	0.0013	0.0009	0.0037
Plasmodium falciparum	hexose transporter	0.0218	0.2253	0.2253
Brugia malayi	Calcium/calmodulin-dependent protein kinase type II alpha chain	0.0067	0.0597	0.2465
Schistosoma mansoni	histone-lysine n-methyltransferase suv9	0.0033	0.0232	0.061
Plasmodium vivax	CDK-related protein kinase 6, putative	0.0923	1	1
Echinococcus multilocularis	solute carrier family 2 facilitated glucose	0.0218	0.2253	0.5919
Trichomonas vaginalis	sugar transporter, putative	0.0031	0.0201	0.0726
Schistosoma mansoni	prolyl oligopeptidase (S09 family)	0.0013	0.0009	0.0023
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0201	0.0832
Trichomonas vaginalis	Clan SC, family S33, methylesterase-like serine peptidase	0.0013	0.0009	0.0032
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0201	0.0832
Trichomonas vaginalis	sugar transporter, putative	0.0031	0.0201	0.0726
Loa Loa (eye worm)	pre-SET domain-containing protein family protein	0.0233	0.2421	1
Trichomonas vaginalis	conserved hypothetical protein	0.0031	0.0201	0.0726
Trichomonas vaginalis	sugar transporter, putative	0.0031	0.0201	0.0726
Loa Loa (eye worm)	sugar transporter	0.0218	0.2253	0.9306
Schistosoma mansoni	ap endonuclease	0.0021	0.0097	0.0254
Mycobacterium ulcerans	exodeoxyribonuclease III protein XthA	0.0021	0.0097	0.2424
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0232	0.0959
Plasmodium vivax	calcium-dependent protein kinase 4, putative	0.0067	0.0597	0.0597
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0201	0.0832
Mycobacterium tuberculosis	Probable peptidase	0.0013	0.0009	0.0278
Giardia lamblia	Alanyl dipeptidyl peptidase	0.0013	0.0009	0.0152
Brugia malayi	hypothetical protein	0.0031	0.0201	0.0832
Leishmania major	glucose transporter, lmgt1	0.0067	0.0606	0.8651
Trichomonas vaginalis	prolylcarboxypeptidase, putative	0.0019	0.0077	0.0279
Leishmania major	protein kinase, putative	0.0067	0.0597	0.8517
Trichomonas vaginalis	conserved hypothetical protein	0.0031	0.0201	0.0726
Trypanosoma brucei	glucose transporter, putative	0.0067	0.0606	0.8651
Onchocerca volvulus		0.0031	0.0201	0.0696
Entamoeba histolytica	hypothetical protein	0.0036	0.0263	0.4407
Trichomonas vaginalis	lysyl-tRNA synthetase, putative	0.0049	0.0399	0.1437
Schistosoma mansoni	family S28 unassigned peptidase (S28 family)	0.0359	0.3807	1
Trypanosoma brucei	myo-inositol/proton symporter (MIT)	0.0031	0.0201	0.2874
Echinococcus granulosus	Lysosomal Pro X carboxypeptidase	0.0019	0.0077	0.0203
Trichomonas vaginalis	sugar transporter, putative	0.0031	0.0201	0.0726
Mycobacterium ulcerans	prolyl-tRNA synthetase	0.0023	0.0119	0.2978
Mycobacterium leprae	Probable lysyl-tRNA synthase LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase)	0.0041	0.0318	0.5469
Trypanosoma cruzi	hexose transporter, putative	0.0037	0.027	0.386
Trichomonas vaginalis	conserved hypothetical protein	0.0019	0.0077	0.0279
Leishmania major	hypothetical protein, conserved	0.0031	0.0201	0.2874
Giardia lamblia	Thymus-specific serine protease precursor	0.0019	0.0077	0.1331
Trypanosoma cruzi	serine carboxypeptidase S28, putative	0.0019	0.0077	0.1105
Mycobacterium ulcerans	sugar-transport integral membrane protein SugI	0.0031	0.0201	0.5052
Giardia lamblia	Alanyl dipeptidyl peptidase	0.0013	0.0009	0.0152
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0201	0.0832
Echinococcus multilocularis	histone lysine methyltransferase setb histone lysine methyltransferase eggless	0.0033	0.0232	0.061
Trypanosoma brucei	oligopeptidase b	0.0013	0.0009	0.0126
Brugia malayi	Sugar transporter family protein	0.0031	0.0201	0.0832
Trichomonas vaginalis	conserved hypothetical protein	0.0019	0.0077	0.0279
Trichomonas vaginalis	glucose transporter, putative	0.0067	0.0606	0.2185
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0077	0.032
Toxoplasma gondii	cell-cycle-associated protein kinase MAPK, putative	0.0352	0.3724	0.5632
Leishmania major	prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative	0.0076	0.0701	1
Mycobacterium tuberculosis	Probable conserved integral membrane transport protein	0.0031	0.0201	0.6328
Trichomonas vaginalis	sugar transporter, putative	0.0031	0.0201	0.0726
Echinococcus granulosus	solute carrier family 2 facilitated glucose	0.0218	0.2253	0.5919
Plasmodium vivax	sugar transporter, putative	0.0031	0.0201	0.0201
Brugia malayi	Major Facilitator Superfamily protein	0.0031	0.0201	0.0832
Entamoeba histolytica	exodeoxyribonuclease III, putative	0.0021	0.0097	0.1619
Echinococcus granulosus	solute carrier family 2 facilitated glucose	0.0218	0.2253	0.5919
Schistosoma mansoni	protein kinase	0.0067	0.0597	0.1568
Mycobacterium tuberculosis	Lysyl-tRNA synthetase 2 LysX	0.0041	0.0318	1
Mycobacterium leprae	Probable prolyl tRNA synthetase ProS	0.0065	0.0582	1
Mycobacterium tuberculosis	Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI)	0.0021	0.0097	0.3036
Echinococcus granulosus	calcium dependent protein kinase	0.0062	0.0552	0.1449
Schistosoma mansoni	glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs)	0.0065	0.0582	0.1529
Trichomonas vaginalis	sugar transporter, putative	0.0031	0.0201	0.0726
Trypanosoma cruzi	prolyl endopeptidase	0.0013	0.0009	0.0126
Schistosoma mansoni	prolyl oligopeptidase (S09 family)	0.0013	0.0009	0.0023
Toxoplasma gondii	transporter, major facilitator family protein	0.0031	0.0201	0.0305
Brugia malayi	Serine protease Z688.6 precursor	0.0019	0.0077	0.032
Echinococcus granulosus	histone lysine methyltransferase setb	0.0033	0.0232	0.061
Plasmodium falciparum	peptidase, putative	0.0013	0.0009	0.0009
Toxoplasma gondii	sugar transporter ST2	0.0031	0.0201	0.0305
Trichomonas vaginalis	Clan SC, family S28, unassigned serine peptidase	0.0019	0.0077	0.0279
Echinococcus multilocularis	solute carrier family 22	0.0031	0.0201	0.0529
Echinococcus granulosus	General substrate transporter	0.0187	0.1918	0.5038
Trichomonas vaginalis	sugar transporter, putative	0.0031	0.0201	0.0726
Echinococcus granulosus	5'partial\|histone lysine N methyltransferase SETDB2	0.0032	0.0219	0.0575
Trichomonas vaginalis	Clan SC, family S28, unassigned serine peptidase	0.0019	0.0077	0.0279
Chlamydia trachomatis	lysine--tRNA ligase	0.0049	0.0399	1
Mycobacterium leprae	PROBABLE PROTEASE II PTRBB (OLIGOPEPTIDASE B)	0.0013	0.0009	0.0152
Brugia malayi	exodeoxyribonuclease III family protein	0.0021	0.0097	0.0399
Toxoplasma gondii	calcium-dependent protein kinase CDPK3	0.0067	0.0597	0.0903
Trypanosoma cruzi	serine carboxypeptidase S28, putative	0.0019	0.0077	0.1105
Plasmodium vivax	hexose transporter	0.0218	0.2253	0.2253
Trypanosoma cruzi	serine peptidase, clan SC, family S9A-like protein, putative	0.0013	0.0009	0.0126
Loa Loa (eye worm)	CAMK/CAMK2 protein kinase	0.0067	0.0597	0.2465
Entamoeba histolytica	serine carboxypeptidase (S28) family protein	0.0019	0.0077	0.1298
Entamoeba histolytica	hypothetical protein, conserved	0.0013	0.0009	0.0149
Loa Loa (eye worm)	hypothetical protein	0.0067	0.0597	0.2465
Schistosoma mansoni	acylaminoacyl-peptidase (S09 family)	0.0013	0.0009	0.0023
Echinococcus multilocularis	calcium:calmodulin dependent protein kinase type	0.0067	0.0597	0.1568
Trypanosoma brucei	THT1 - hexose transporter, putative	0.0067	0.0606	0.8651
Echinococcus multilocularis	calcium:calmodulin dependent protein kinase type	0.0067	0.0597	0.1568
Plasmodium vivax	calcium-dependent protein kinase 3, putative	0.0067	0.0597	0.0597
Echinococcus multilocularis	solute carrier family 2 facilitated glucose	0.0218	0.2253	0.5919
Entamoeba histolytica	prolyl-tRNA synthetase, putative	0.0065	0.0582	0.9752
Trichomonas vaginalis	glucose transporter, putative	0.0067	0.0606	0.2185
Trypanosoma brucei	glucose transporter, putative	0.0067	0.0606	0.8651
Loa Loa (eye worm)	bifunctional aminoacyl-tRNA synthetase	0.0027	0.016	0.066
Giardia lamblia	Serine peptidase, putative	0.0019	0.0077	0.1331
Onchocerca volvulus		0.0031	0.0201	0.0696
Trichomonas vaginalis	Clan SC, family S28, unassigned serine peptidase	0.0019	0.0077	0.0279
Chlamydia trachomatis	proline--tRNA ligase	0.0023	0.0119	0.2978
Trichomonas vaginalis	sugar transporter, putative	0.0031	0.0201	0.0726
Onchocerca volvulus		0.0031	0.0201	0.0696
Brugia malayi	prolyl oligopeptidase family protein	0.0165	0.1672	0.6906
Plasmodium vivax	calcium-dependent protein kinase 1, putative	0.0067	0.0597	0.0597
Brugia malayi	major facilitator superfamily protein	0.0031	0.0201	0.0832
Plasmodium falciparum	proline--tRNA ligase	0.0076	0.0701	0.0701
Brugia malayi	Sugar transporter family protein	0.0218	0.2253	0.9306
Plasmodium falciparum	mitogen-activated protein kinase 2	0.0352	0.3724	0.3724
Trichomonas vaginalis	glucose transporter, putative	0.0031	0.0201	0.0726
Giardia lamblia	Endonuclease/Exonuclease/phosphatase	0.0021	0.0097	0.166
Trichomonas vaginalis	sugar transporter, putative	0.0031	0.0201	0.0726
Schistosoma mansoni	protein kinase	0.0067	0.0597	0.1568
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease, putative	0.0021	0.0097	0.1379
Trypanosoma brucei	bifunctional aminoacyl-tRNA synthetase, putative	0.0076	0.0701	1
Toxoplasma gondii	protein kinase, putative	0.0615	0.6612	1
Plasmodium vivax	mitogen-activated protein kinase 2, putative	0.0352	0.3724	0.3724
Trypanosoma cruzi	prolyl-tRNA synthetase, putative	0.0076	0.0701	1
Trypanosoma cruzi	hexose transporter, putative	0.0031	0.0201	0.2874
Toxoplasma gondii	prolyl endopeptidase	0.0013	0.0009	0.0013
Trichomonas vaginalis	conserved hypothetical protein	0.0067	0.0606	0.2185
Brugia malayi	Pre-SET motif family protein	0.0233	0.2421	1
Trypanosoma brucei	glucose transporter, putative	0.0067	0.0606	0.8651
Trichomonas vaginalis	Clan SC, family S28, unassigned serine peptidase	0.0019	0.0077	0.0279
Echinococcus granulosus	DNA apurinic or apyrimidinic site lyase	0.0021	0.0097	0.0254
Onchocerca volvulus		0.0031	0.0201	0.0696
Trichomonas vaginalis	sugar transporter, putative	0.0031	0.0201	0.0726
Echinococcus multilocularis	synaptic vesicle 2 protein	0.0031	0.0201	0.0529
Brugia malayi	Major Facilitator Superfamily protein	0.0031	0.0201	0.0832
Loa Loa (eye worm)	hypothetical protein	0.0049	0.0399	0.1646
Brugia malayi	Serine protease Z688.6 precursor	0.0019	0.0077	0.032
Onchocerca volvulus	Dipeptidyl peptidase family member 1 homolog	0.0165	0.1672	0.6015
Loa Loa (eye worm)	hypothetical protein	0.0013	0.0009	0.0037
Mycobacterium ulcerans	lysyl-tRNA synthetase	0.0049	0.0399	1
Echinococcus multilocularis	solute carrier family 2 facilitated glucose	0.0218	0.2253	0.5919
Trypanosoma cruzi	dipeptidyl-peptidase 8-like serine peptidase	0.0055	0.0473	0.6752
Mycobacterium ulcerans	integral membrane transport protein	0.0031	0.0201	0.5052
Trichomonas vaginalis	sugar transporter, putative	0.0031	0.0201	0.0726
Trypanosoma brucei	glucose transporter, putative	0.0067	0.0606	0.8651
Echinococcus granulosus	acylamino acid releasing enzyme	0.0013	0.0009	0.0023
Trichomonas vaginalis	CAMK family protein kinase	0.0067	0.0597	0.2151
Trypanosoma brucei	glucose transporter 1E	0.0067	0.0606	0.8651
Trypanosoma brucei	prolyl endopeptidase	0.0013	0.0009	0.0126
Trypanosoma cruzi	oligopeptidase b	0.0013	0.0009	0.0126
Mycobacterium tuberculosis	Lysyl-tRNA synthetase 1 LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase)	0.0041	0.0318	1
Brugia malayi	prolyl oligopeptidase family protein	0.0013	0.0009	0.0037
Trypanosoma cruzi	sugar transporter, putative	0.0031	0.0201	0.2874
Trypanosoma brucei	glucose transporter, putative	0.0067	0.0606	0.8651
Trichomonas vaginalis	conserved hypothetical protein	0.0218	0.2253	0.8122
Trypanosoma brucei	glucose transporter, putative	0.0067	0.0606	0.8651
Toxoplasma gondii	exonuclease III APE	0.0021	0.0097	0.0146
Trypanosoma cruzi	hypothetical protein, conserved	0.0013	0.0009	0.0127
Echinococcus multilocularis	solute carrier family 22	0.0031	0.0201	0.0529
Brugia malayi	lysyl-tRNA synthetase	0.0049	0.0399	0.1646
Leishmania major	oligopeptidase B-like protein,serine peptidase, clan SC, family S9A-like protein	0.0013	0.0009	0.0126
Plasmodium falciparum	calcium-dependent protein kinase 5	0.0067	0.0597	0.0597
Schistosoma mansoni	sugar transporter	0.0031	0.0201	0.0529
Echinococcus granulosus	glutamyl tRNA synthetase cytoplasmic	0.0065	0.0582	0.1529
Loa Loa (eye worm)	hypothetical protein	0.0042	0.033	0.1362
Trichomonas vaginalis	sugar transporter, putative	0.0031	0.0201	0.0726
Mycobacterium ulcerans	fusion protein of transposase for IS2606 and sialic acid-transport integral membrane protein NanT	0.0031	0.0201	0.5052
Plasmodium vivax	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	0.0021	0.0097	0.0097
Plasmodium vivax	hypothetical protein, conserved	0.0013	0.0009	0.0009
Echinococcus multilocularis	calcium dependent protein kinase	0.0062	0.0552	0.1449
Loa Loa (eye worm)	hypothetical protein	0.0053	0.0448	0.1849
Toxoplasma gondii	serine carboxypeptidase s28 protein	0.0019	0.0077	0.0117
Schistosoma mansoni	sugar transporter	0.0031	0.0201	0.0529
Treponema pallidum	prolyl-tRNA synthetase	0.0023	0.0119	1
Giardia lamblia	Lysyl-tRNA synthetase	0.0049	0.0399	0.6849
Echinococcus multilocularis	calcium:calmodulin dependent protein kinase type	0.0067	0.0597	0.1568
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0201	0.0832
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0201	0.0832
Schistosoma mansoni	glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs)	0.0065	0.0582	0.1529
Schistosoma mansoni	lysyl-tRNA synthetase	0.0049	0.0399	0.1047
Mycobacterium ulcerans	protease II (oligopeptidase B), PtrB	0.0013	0.0009	0.0222
Loa Loa (eye worm)	prolyl oligopeptidase	0.0013	0.0009	0.0037
Trichomonas vaginalis	sugar transporter, putative	0.0067	0.0606	0.2185
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0033	0.0232	0.061
Entamoeba histolytica	dipeptidyl-peptidase, putative	0.0013	0.0009	0.0149
Schistosoma mansoni	glucose transporter	0.0031	0.0201	0.0529
Trichomonas vaginalis	sugar transporter, putative	0.0067	0.0606	0.2185
Trichomonas vaginalis	conserved hypothetical protein	0.0067	0.0606	0.2185
Onchocerca volvulus		0.0031	0.0201	0.0696
Trypanosoma cruzi	lysyl-tRNA synthetase, putative	0.0049	0.0399	0.5689
Echinococcus multilocularis	Sugar transporter ERD6 protein	0.0031	0.0201	0.0529
Leishmania major	lysyl-tRNA synthetase, putative	0.0049	0.0399	0.5689
Trichomonas vaginalis	sugar transporter, putative	0.0031	0.0201	0.0726
Trichomonas vaginalis	conserved hypothetical protein	0.0013	0.0009	0.0032
Loa Loa (eye worm)	major facilitator superfamily transporter	0.0031	0.0201	0.0832
Trypanosoma brucei	THT1 - hexose transporter, putative	0.0067	0.0606	0.8651
Entamoeba histolytica	protein kinase, putative	0.0067	0.0597	1
Toxoplasma gondii	facilitative glucose transporter GT1	0.0218	0.2253	0.3408
Loa Loa (eye worm)	major facilitator superfamily transporter	0.0031	0.0201	0.0832
Entamoeba histolytica	hypothetical protein	0.0036	0.0263	0.4407
Toxoplasma gondii	acylaminoacyl-peptidase, putative	0.0013	0.0009	0.0013
Giardia lamblia	Hexose transporter	0.0031	0.0201	0.346
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease	0.0021	0.0097	0.1379
Leishmania major	apurinic/apyrimidinic endonuclease-redox protein	0.0021	0.0097	0.1379
Plasmodium vivax	lysine--tRNA ligase, putative	0.0049	0.0399	0.0399
Brugia malayi	Major Facilitator Superfamily protein	0.0031	0.0201	0.0832
Leishmania major	prolyl oligopeptidase, putative,serine peptidase clan SC, family S9A, putative	0.0013	0.0009	0.0126
Trypanosoma brucei	glucose transporter, putative	0.0067	0.0606	0.8651
Brugia malayi	hypothetical protein	0.0036	0.0263	0.1086
Plasmodium vivax	proline--tRNA ligase, putative	0.0076	0.0701	0.0701
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0201	0.0832
Trichomonas vaginalis	sugar transporter, putative	0.0031	0.0201	0.0726
Entamoeba histolytica	prolyl oligopeptidase family protein	0.0013	0.0009	0.0149
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0201	0.0832
Onchocerca volvulus		0.0031	0.0201	0.0696
Trypanosoma brucei	calcium/calmodulin-dependent protein kinase, putative	0.0067	0.0597	0.8517
Trichomonas vaginalis	Clan SC, family S9, acylaminoacyl-peptidase-like serine peptidase	0.0013	0.0009	0.0032
Echinococcus granulosus	Dipeptidyl peptidase 9	0.0055	0.0473	0.1243
Trichomonas vaginalis	sugar transporter, putative	0.0031	0.0201	0.0726
Schistosoma mansoni	lysosomal Pro-Xaa carboxypeptidase (S28 family)	0.0019	0.0077	0.0203
Trichomonas vaginalis	sugar transporter, putative	0.0031	0.0201	0.0726
Schistosoma mansoni	dipeptidyl-peptidase 9 (S09 family)	0.0055	0.0473	0.1243
Echinococcus multilocularis	DNA (apurinic or apyrimidinic site) lyase	0.0021	0.0097	0.0254
Onchocerca volvulus		0.0031	0.0201	0.0696
Loa Loa (eye worm)	prolyl oligopeptidase	0.0165	0.1672	0.6906
Loa Loa (eye worm)	sugar transporter	0.0031	0.0201	0.0832
Onchocerca volvulus	Putative transporter	0.0031	0.0201	0.0696
Brugia malayi	bifunctional aminoacyl-tRNA synthetase	0.0065	0.0582	0.2404
Leishmania major	prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative	0.0076	0.0701	1
Trichomonas vaginalis	sugar transporter, putative	0.0031	0.0201	0.0726
Echinococcus multilocularis	solute carrier family 22	0.0031	0.0201	0.0529
Plasmodium falciparum	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	0.0021	0.0097	0.0097
Plasmodium falciparum	major facilitator superfamily domain-containing protein, putative	0.0031	0.0201	0.0201
Brugia malayi	prolyl oligopeptidase family protein	0.0013	0.0009	0.0037
Trichomonas vaginalis	sugar transporter, putative	0.0031	0.0201	0.0726
Echinococcus granulosus	synaptic vesicle 2 protein	0.0031	0.0201	0.0529
Trichomonas vaginalis	prolyl-tRNA synthetase, putative	0.0065	0.0582	0.2098
Trichomonas vaginalis	sugar transporter, putative	0.0031	0.0201	0.0726
Toxoplasma gondii	calcium-dependent protein kinase CDPK2A	0.0067	0.0597	0.0903
Trypanosoma brucei	THT1 - hexose transporter, putative	0.0067	0.0606	0.8651
Trichomonas vaginalis	sugar transporter, putative	0.0031	0.0201	0.0726
Trypanosoma brucei	lysyl-tRNA synthetase, putative	0.0049	0.0399	0.5689
Schistosoma mansoni	lysyl-tRNA synthetase	0.0049	0.0399	0.1047
Trypanosoma brucei	sugar transporter, putative	0.0031	0.0201	0.2874
Trypanosoma cruzi	hexose transporter, putative	0.0067	0.0606	0.8651
Trichomonas vaginalis	ap endonuclease, putative	0.0021	0.0097	0.0348
Schistosoma mansoni	transcription factor LCR-F1	0.0036	0.0263	0.0691
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0036	0.0263	0.0691
Brugia malayi	major facilitator superfamily protein	0.0031	0.0201	0.0832
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0077	0.032
Schistosoma mansoni	glucose transport protein	0.0218	0.2253	0.5919
Trypanosoma cruzi	prolyl-tRNA synthetase, putative	0.0076	0.0701	1
Echinococcus multilocularis	glutamyl tRNA synthetase cytoplasmic	0.0065	0.0582	0.1529
Onchocerca volvulus		0.0031	0.0201	0.0696
Echinococcus granulosus	calcium:calmodulin dependent protein kinase type	0.0067	0.0597	0.1568
Trichomonas vaginalis	sugar transport protein, putative	0.0031	0.0201	0.0726
Trypanosoma brucei	glucose transporter 2A	0.0067	0.0606	0.8651
Toxoplasma gondii	histone lysine methyltransferase SET/SUV39	0.0033	0.0232	0.0351
Echinococcus multilocularis	solute carrier family 22	0.0031	0.0201	0.0529
Echinococcus granulosus	calcium:calmodulin dependent protein kinase type	0.0067	0.0597	0.1568
Trichomonas vaginalis	conserved hypothetical protein	0.0031	0.0201	0.0726
Giardia lamblia	Sugar-proton symporter	0.0031	0.0201	0.346
Toxoplasma gondii	sugar transporter ST1	0.0031	0.0201	0.0305
Trypanosoma brucei	Alpha/beta hydrolase domain-containing protein	0.0013	0.0009	0.0126
Brugia malayi	Sugar transporter family protein	0.0031	0.0201	0.0832
Echinococcus multilocularis	histone lysine N methyltransferase SETMAR	0.0033	0.0232	0.061
Echinococcus granulosus	solute carrier family 22	0.0031	0.0201	0.0529
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0201	0.0832
Trypanosoma brucei	Dipeptidyl-peptidase 8-like, putative	0.0055	0.0473	0.6752
Trichomonas vaginalis	conserved hypothetical protein	0.0031	0.0201	0.0726
Echinococcus granulosus	calcium:calmodulin dependent protein kinase type 1	0.0067	0.0597	0.1568
Onchocerca volvulus		0.0031	0.0201	0.0696

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Search by Saint Jude

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 763654