TDR Targets

Basic information

Technical information

TDR Targets ID: 763693
Name: 2-cyano-3-[2-(4-ethylphenoxy)-4-oxopyrido[1,2 -a]pyrimidin-3-yl]-N-(furan-2-ylmethyl)prop-2 -enamide
MW: 440.451 | Formula: C25H20N4O4
H donors: 1 H acceptors: 3 LogP: 2.89 Rotable bonds: 8
Rule of 5 violations (Lipinski): 1
SMILES: N#CC(=Cc1c(Oc2ccc(cc2)CC)nc2n(c1=O)cccc2)C(=O)NCc1ccco1
InChi: 1S/C25H20N4O4/c1-2-17-8-10-19(11-9-17)33-24-21(25(31)29-12-4-3-7-22(29)28-24)14-18(15-26)23(30)27-16-20-6-5-13-32-20/h3-14H,2,16H2,1H3,(H,27,30)/b18-14+
InChiKey: RRFFGEPEVFKLGX-NBVRZTHBSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

(E)-2-cyano-3-[2-(4-ethylphenoxy)-4-oxopyrido[1,2-a]pyrimidin-3-yl]-N-(furan-2-ylmethyl)prop-2-enamide
2-cyano-3-[2-(4-ethylphenoxy)-4-oxo-pyrido[1,2-a]pyrimidin-3-yl]-N-(2-furylmethyl)prop-2-enamide
(E)-2-cyano-3-[2-(4-ethylphenoxy)-4-oxo-pyrido[1,2-a]pyrimidin-3-yl]-N-(2-furylmethyl)prop-2-enamide
(E)-2-cyano-3-[2-(4-ethylphenoxy)-4-oxo-3-pyrido[1,2-a]pyrimidinyl]-N-(2-furylmethyl)prop-2-enamide
2-cyano-3-[2-(4-ethylphenoxy)-4-oxo-3-pyrido[1,2-a]pyrimidinyl]-N-(2-furylmethyl)prop-2-enamide
(E)-2-cyano-3-[2-(4-ethylphenoxy)-4-keto-pyrido[1,2-a]pyrimidin-3-yl]-N-(2-furylmethyl)acrylamide
2-cyano-3-[2-(4-ethylphenoxy)-4-keto-pyrido[1,2-a]pyrimidin-3-yl]-N-(2-furylmethyl)acrylamide
(E)-2-cyano-3-[2-(4-ethylphenoxy)-4-oxo-pyrido[1,2-a]pyrimidin-3-yl]-N-(furan-2-ylmethyl)prop-2-enamide
2-cyano-3-[2-(4-ethylphenoxy)-4-oxo-pyrido[1,2-a]pyrimidin-3-yl]-N-(furan-2-ylmethyl)prop-2-enamide
STOCK4S-33423

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0077	0.032
Trichomonas vaginalis	glucose transporter, putative	0.0067	0.0606	0.2185
Trichomonas vaginalis	conserved hypothetical protein	0.0019	0.0077	0.0279
Leishmania major	prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative	0.0076	0.0701	1
Toxoplasma gondii	cell-cycle-associated protein kinase MAPK, putative	0.0352	0.3724	0.5632
Mycobacterium tuberculosis	Probable conserved integral membrane transport protein	0.0031	0.0201	0.6328
Echinococcus multilocularis	histone lysine methyltransferase setb histone lysine methyltransferase eggless	0.0033	0.0232	0.061
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0201	0.0832
Trypanosoma brucei	oligopeptidase b	0.0013	0.0009	0.0126
Brugia malayi	Sugar transporter family protein	0.0031	0.0201	0.0832
Echinococcus granulosus	calcium dependent protein kinase	0.0062	0.0552	0.1449
Schistosoma mansoni	glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs)	0.0065	0.0582	0.1529
Trypanosoma cruzi	prolyl endopeptidase	0.0013	0.0009	0.0126
Trichomonas vaginalis	sugar transporter, putative	0.0031	0.0201	0.0726
Echinococcus granulosus	histone lysine methyltransferase setb	0.0033	0.0232	0.061
Brugia malayi	Serine protease Z688.6 precursor	0.0019	0.0077	0.032
Plasmodium falciparum	peptidase, putative	0.0013	0.0009	0.0009
Toxoplasma gondii	transporter, major facilitator family protein	0.0031	0.0201	0.0305
Schistosoma mansoni	prolyl oligopeptidase (S09 family)	0.0013	0.0009	0.0023
Echinococcus granulosus	solute carrier family 2 facilitated glucose	0.0218	0.2253	0.5919
Brugia malayi	Major Facilitator Superfamily protein	0.0031	0.0201	0.0832
Plasmodium vivax	sugar transporter, putative	0.0031	0.0201	0.0201
Trichomonas vaginalis	sugar transporter, putative	0.0031	0.0201	0.0726
Echinococcus granulosus	solute carrier family 2 facilitated glucose	0.0218	0.2253	0.5919
Entamoeba histolytica	exodeoxyribonuclease III, putative	0.0021	0.0097	0.1619
Mycobacterium leprae	Probable prolyl tRNA synthetase ProS	0.0065	0.0582	1
Mycobacterium tuberculosis	Lysyl-tRNA synthetase 2 LysX	0.0041	0.0318	1
Schistosoma mansoni	protein kinase	0.0067	0.0597	0.1568
Mycobacterium tuberculosis	Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI)	0.0021	0.0097	0.3036
Mycobacterium leprae	PROBABLE PROTEASE II PTRBB (OLIGOPEPTIDASE B)	0.0013	0.0009	0.0152
Trypanosoma cruzi	serine carboxypeptidase S28, putative	0.0019	0.0077	0.1105
Plasmodium vivax	hexose transporter	0.0218	0.2253	0.2253
Toxoplasma gondii	calcium-dependent protein kinase CDPK3	0.0067	0.0597	0.0903
Brugia malayi	exodeoxyribonuclease III family protein	0.0021	0.0097	0.0399
Entamoeba histolytica	serine carboxypeptidase (S28) family protein	0.0019	0.0077	0.1298
Loa Loa (eye worm)	CAMK/CAMK2 protein kinase	0.0067	0.0597	0.2465
Trypanosoma cruzi	serine peptidase, clan SC, family S9A-like protein, putative	0.0013	0.0009	0.0126
Entamoeba histolytica	hypothetical protein, conserved	0.0013	0.0009	0.0149
Loa Loa (eye worm)	hypothetical protein	0.0067	0.0597	0.2465
Echinococcus granulosus	General substrate transporter	0.0187	0.1918	0.5038
Echinococcus multilocularis	solute carrier family 22	0.0031	0.0201	0.0529
Trichomonas vaginalis	Clan SC, family S28, unassigned serine peptidase	0.0019	0.0077	0.0279
Toxoplasma gondii	sugar transporter ST2	0.0031	0.0201	0.0305
Echinococcus granulosus	5'partial\|histone lysine N methyltransferase SETDB2	0.0032	0.0219	0.0575
Trichomonas vaginalis	sugar transporter, putative	0.0031	0.0201	0.0726
Trichomonas vaginalis	Clan SC, family S28, unassigned serine peptidase	0.0019	0.0077	0.0279
Chlamydia trachomatis	lysine--tRNA ligase	0.0049	0.0399	1
Echinococcus multilocularis	solute carrier family 2 facilitated glucose	0.0218	0.2253	0.5919
Plasmodium vivax	calcium-dependent protein kinase 3, putative	0.0067	0.0597	0.0597
Trypanosoma brucei	glucose transporter, putative	0.0067	0.0606	0.8651
Trichomonas vaginalis	glucose transporter, putative	0.0067	0.0606	0.2185
Entamoeba histolytica	prolyl-tRNA synthetase, putative	0.0065	0.0582	0.9752
Loa Loa (eye worm)	bifunctional aminoacyl-tRNA synthetase	0.0027	0.016	0.066
Echinococcus multilocularis	calcium:calmodulin dependent protein kinase type	0.0067	0.0597	0.1568
Schistosoma mansoni	acylaminoacyl-peptidase (S09 family)	0.0013	0.0009	0.0023
Trypanosoma brucei	THT1 - hexose transporter, putative	0.0067	0.0606	0.8651
Echinococcus multilocularis	calcium:calmodulin dependent protein kinase type	0.0067	0.0597	0.1568
Trichomonas vaginalis	glucose transporter, putative	0.0031	0.0201	0.0726
Giardia lamblia	Endonuclease/Exonuclease/phosphatase	0.0021	0.0097	0.166
Trichomonas vaginalis	sugar transporter, putative	0.0031	0.0201	0.0726
Trypanosoma brucei	bifunctional aminoacyl-tRNA synthetase, putative	0.0076	0.0701	1
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease, putative	0.0021	0.0097	0.1379
Schistosoma mansoni	protein kinase	0.0067	0.0597	0.1568
Trypanosoma cruzi	prolyl-tRNA synthetase, putative	0.0076	0.0701	1
Plasmodium vivax	mitogen-activated protein kinase 2, putative	0.0352	0.3724	0.3724
Toxoplasma gondii	protein kinase, putative	0.0615	0.6612	1
Trichomonas vaginalis	Clan SC, family S28, unassigned serine peptidase	0.0019	0.0077	0.0279
Onchocerca volvulus		0.0031	0.0201	0.0696
Giardia lamblia	Serine peptidase, putative	0.0019	0.0077	0.1331
Trichomonas vaginalis	sugar transporter, putative	0.0031	0.0201	0.0726
Brugia malayi	prolyl oligopeptidase family protein	0.0165	0.1672	0.6906
Onchocerca volvulus		0.0031	0.0201	0.0696
Chlamydia trachomatis	proline--tRNA ligase	0.0023	0.0119	0.2978
Plasmodium falciparum	mitogen-activated protein kinase 2	0.0352	0.3724	0.3724
Brugia malayi	Sugar transporter family protein	0.0218	0.2253	0.9306
Plasmodium vivax	calcium-dependent protein kinase 1, putative	0.0067	0.0597	0.0597
Brugia malayi	major facilitator superfamily protein	0.0031	0.0201	0.0832
Plasmodium falciparum	proline--tRNA ligase	0.0076	0.0701	0.0701
Trichomonas vaginalis	sugar transporter, putative	0.0031	0.0201	0.0726
Onchocerca volvulus		0.0031	0.0201	0.0696
Echinococcus granulosus	DNA apurinic or apyrimidinic site lyase	0.0021	0.0097	0.0254
Brugia malayi	Major Facilitator Superfamily protein	0.0031	0.0201	0.0832
Echinococcus multilocularis	synaptic vesicle 2 protein	0.0031	0.0201	0.0529
Brugia malayi	Serine protease Z688.6 precursor	0.0019	0.0077	0.032
Onchocerca volvulus	Dipeptidyl peptidase family member 1 homolog	0.0165	0.1672	0.6015
Loa Loa (eye worm)	hypothetical protein	0.0049	0.0399	0.1646
Trypanosoma cruzi	hexose transporter, putative	0.0031	0.0201	0.2874
Toxoplasma gondii	prolyl endopeptidase	0.0013	0.0009	0.0013
Trichomonas vaginalis	conserved hypothetical protein	0.0067	0.0606	0.2185
Brugia malayi	Pre-SET motif family protein	0.0233	0.2421	1
Trichomonas vaginalis	Clan SC, family S28, unassigned serine peptidase	0.0019	0.0077	0.0279
Trypanosoma brucei	glucose transporter, putative	0.0067	0.0606	0.8651
Trichomonas vaginalis	CAMK family protein kinase	0.0067	0.0597	0.2151
Trypanosoma brucei	glucose transporter 1E	0.0067	0.0606	0.8651
Trypanosoma brucei	prolyl endopeptidase	0.0013	0.0009	0.0126
Mycobacterium tuberculosis	Lysyl-tRNA synthetase 1 LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase)	0.0041	0.0318	1
Trypanosoma cruzi	oligopeptidase b	0.0013	0.0009	0.0126
Trypanosoma cruzi	sugar transporter, putative	0.0031	0.0201	0.2874
Brugia malayi	prolyl oligopeptidase family protein	0.0013	0.0009	0.0037
Mycobacterium ulcerans	lysyl-tRNA synthetase	0.0049	0.0399	1
Loa Loa (eye worm)	hypothetical protein	0.0013	0.0009	0.0037
Echinococcus multilocularis	solute carrier family 2 facilitated glucose	0.0218	0.2253	0.5919
Trichomonas vaginalis	sugar transporter, putative	0.0031	0.0201	0.0726
Mycobacterium ulcerans	integral membrane transport protein	0.0031	0.0201	0.5052
Trypanosoma brucei	glucose transporter, putative	0.0067	0.0606	0.8651
Trypanosoma cruzi	dipeptidyl-peptidase 8-like serine peptidase	0.0055	0.0473	0.6752
Echinococcus granulosus	acylamino acid releasing enzyme	0.0013	0.0009	0.0023
Leishmania major	oligopeptidase B-like protein,serine peptidase, clan SC, family S9A-like protein	0.0013	0.0009	0.0126
Brugia malayi	lysyl-tRNA synthetase	0.0049	0.0399	0.1646
Echinococcus multilocularis	solute carrier family 22	0.0031	0.0201	0.0529
Schistosoma mansoni	sugar transporter	0.0031	0.0201	0.0529
Plasmodium falciparum	calcium-dependent protein kinase 5	0.0067	0.0597	0.0597
Echinococcus granulosus	glutamyl tRNA synthetase cytoplasmic	0.0065	0.0582	0.1529
Mycobacterium ulcerans	fusion protein of transposase for IS2606 and sialic acid-transport integral membrane protein NanT	0.0031	0.0201	0.5052
Trichomonas vaginalis	sugar transporter, putative	0.0031	0.0201	0.0726
Loa Loa (eye worm)	hypothetical protein	0.0042	0.033	0.1362
Trichomonas vaginalis	conserved hypothetical protein	0.0218	0.2253	0.8122
Trypanosoma brucei	glucose transporter, putative	0.0067	0.0606	0.8651
Trypanosoma brucei	glucose transporter, putative	0.0067	0.0606	0.8651
Trypanosoma cruzi	hypothetical protein, conserved	0.0013	0.0009	0.0127
Toxoplasma gondii	exonuclease III APE	0.0021	0.0097	0.0146
Schistosoma mansoni	sugar transporter	0.0031	0.0201	0.0529
Giardia lamblia	Lysyl-tRNA synthetase	0.0049	0.0399	0.6849
Treponema pallidum	prolyl-tRNA synthetase	0.0023	0.0119	1
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0201	0.0832
Echinococcus multilocularis	calcium:calmodulin dependent protein kinase type	0.0067	0.0597	0.1568
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0201	0.0832
Plasmodium vivax	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	0.0021	0.0097	0.0097
Plasmodium vivax	hypothetical protein, conserved	0.0013	0.0009	0.0009
Echinococcus multilocularis	calcium dependent protein kinase	0.0062	0.0552	0.1449
Loa Loa (eye worm)	hypothetical protein	0.0053	0.0448	0.1849
Toxoplasma gondii	serine carboxypeptidase s28 protein	0.0019	0.0077	0.0117
Loa Loa (eye worm)	prolyl oligopeptidase	0.0013	0.0009	0.0037
Trichomonas vaginalis	sugar transporter, putative	0.0067	0.0606	0.2185
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0033	0.0232	0.061
Entamoeba histolytica	dipeptidyl-peptidase, putative	0.0013	0.0009	0.0149
Trichomonas vaginalis	sugar transporter, putative	0.0067	0.0606	0.2185
Schistosoma mansoni	glucose transporter	0.0031	0.0201	0.0529
Schistosoma mansoni	glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs)	0.0065	0.0582	0.1529
Schistosoma mansoni	lysyl-tRNA synthetase	0.0049	0.0399	0.1047
Mycobacterium ulcerans	protease II (oligopeptidase B), PtrB	0.0013	0.0009	0.0222
Entamoeba histolytica	protein kinase, putative	0.0067	0.0597	1
Trypanosoma brucei	THT1 - hexose transporter, putative	0.0067	0.0606	0.8651
Toxoplasma gondii	facilitative glucose transporter GT1	0.0218	0.2253	0.3408
Entamoeba histolytica	hypothetical protein	0.0036	0.0263	0.4407
Loa Loa (eye worm)	major facilitator superfamily transporter	0.0031	0.0201	0.0832
Toxoplasma gondii	acylaminoacyl-peptidase, putative	0.0013	0.0009	0.0013
Giardia lamblia	Hexose transporter	0.0031	0.0201	0.346
Trichomonas vaginalis	conserved hypothetical protein	0.0067	0.0606	0.2185
Onchocerca volvulus		0.0031	0.0201	0.0696
Trichomonas vaginalis	sugar transporter, putative	0.0031	0.0201	0.0726
Leishmania major	lysyl-tRNA synthetase, putative	0.0049	0.0399	0.5689
Echinococcus multilocularis	Sugar transporter ERD6 protein	0.0031	0.0201	0.0529
Trypanosoma cruzi	lysyl-tRNA synthetase, putative	0.0049	0.0399	0.5689
Loa Loa (eye worm)	major facilitator superfamily transporter	0.0031	0.0201	0.0832
Trichomonas vaginalis	conserved hypothetical protein	0.0013	0.0009	0.0032
Entamoeba histolytica	prolyl oligopeptidase family protein	0.0013	0.0009	0.0149
Trichomonas vaginalis	sugar transporter, putative	0.0031	0.0201	0.0726
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0201	0.0832
Onchocerca volvulus		0.0031	0.0201	0.0696
Trypanosoma brucei	calcium/calmodulin-dependent protein kinase, putative	0.0067	0.0597	0.8517
Trichomonas vaginalis	Clan SC, family S9, acylaminoacyl-peptidase-like serine peptidase	0.0013	0.0009	0.0032
Plasmodium vivax	lysine--tRNA ligase, putative	0.0049	0.0399	0.0399
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease	0.0021	0.0097	0.1379
Leishmania major	apurinic/apyrimidinic endonuclease-redox protein	0.0021	0.0097	0.1379
Trypanosoma brucei	glucose transporter, putative	0.0067	0.0606	0.8651
Leishmania major	prolyl oligopeptidase, putative,serine peptidase clan SC, family S9A, putative	0.0013	0.0009	0.0126
Brugia malayi	Major Facilitator Superfamily protein	0.0031	0.0201	0.0832
Plasmodium vivax	proline--tRNA ligase, putative	0.0076	0.0701	0.0701
Brugia malayi	hypothetical protein	0.0036	0.0263	0.1086
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0201	0.0832
Loa Loa (eye worm)	prolyl oligopeptidase	0.0165	0.1672	0.6906
Loa Loa (eye worm)	sugar transporter	0.0031	0.0201	0.0832
Onchocerca volvulus	Putative transporter	0.0031	0.0201	0.0696
Echinococcus granulosus	Dipeptidyl peptidase 9	0.0055	0.0473	0.1243
Trichomonas vaginalis	sugar transporter, putative	0.0031	0.0201	0.0726
Schistosoma mansoni	lysosomal Pro-Xaa carboxypeptidase (S28 family)	0.0019	0.0077	0.0203
Trichomonas vaginalis	sugar transporter, putative	0.0031	0.0201	0.0726
Schistosoma mansoni	dipeptidyl-peptidase 9 (S09 family)	0.0055	0.0473	0.1243
Echinococcus multilocularis	DNA (apurinic or apyrimidinic site) lyase	0.0021	0.0097	0.0254
Onchocerca volvulus		0.0031	0.0201	0.0696
Trichomonas vaginalis	prolyl-tRNA synthetase, putative	0.0065	0.0582	0.2098
Trichomonas vaginalis	sugar transporter, putative	0.0031	0.0201	0.0726
Toxoplasma gondii	calcium-dependent protein kinase CDPK2A	0.0067	0.0597	0.0903
Trypanosoma brucei	THT1 - hexose transporter, putative	0.0067	0.0606	0.8651
Trichomonas vaginalis	sugar transporter, putative	0.0031	0.0201	0.0726
Echinococcus multilocularis	solute carrier family 22	0.0031	0.0201	0.0529
Leishmania major	prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative	0.0076	0.0701	1
Brugia malayi	bifunctional aminoacyl-tRNA synthetase	0.0065	0.0582	0.2404
Plasmodium falciparum	major facilitator superfamily domain-containing protein, putative	0.0031	0.0201	0.0201
Plasmodium falciparum	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	0.0021	0.0097	0.0097
Brugia malayi	prolyl oligopeptidase family protein	0.0013	0.0009	0.0037
Echinococcus granulosus	synaptic vesicle 2 protein	0.0031	0.0201	0.0529
Trichomonas vaginalis	sugar transporter, putative	0.0031	0.0201	0.0726
Schistosoma mansoni	glucose transport protein	0.0218	0.2253	0.5919
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0077	0.032
Trypanosoma cruzi	prolyl-tRNA synthetase, putative	0.0076	0.0701	1
Echinococcus granulosus	calcium:calmodulin dependent protein kinase type	0.0067	0.0597	0.1568
Onchocerca volvulus		0.0031	0.0201	0.0696
Echinococcus multilocularis	glutamyl tRNA synthetase cytoplasmic	0.0065	0.0582	0.1529
Trypanosoma brucei	glucose transporter 2A	0.0067	0.0606	0.8651
Trichomonas vaginalis	sugar transport protein, putative	0.0031	0.0201	0.0726
Trichomonas vaginalis	sugar transporter, putative	0.0031	0.0201	0.0726
Trypanosoma cruzi	hexose transporter, putative	0.0067	0.0606	0.8651
Trypanosoma brucei	sugar transporter, putative	0.0031	0.0201	0.2874
Trypanosoma brucei	lysyl-tRNA synthetase, putative	0.0049	0.0399	0.5689
Schistosoma mansoni	lysyl-tRNA synthetase	0.0049	0.0399	0.1047
Brugia malayi	major facilitator superfamily protein	0.0031	0.0201	0.0832
Schistosoma mansoni	transcription factor LCR-F1	0.0036	0.0263	0.0691
Trichomonas vaginalis	ap endonuclease, putative	0.0021	0.0097	0.0348
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0036	0.0263	0.0691
Echinococcus granulosus	solute carrier family 22	0.0031	0.0201	0.0529
Echinococcus multilocularis	histone lysine N methyltransferase SETMAR	0.0033	0.0232	0.061
Trypanosoma brucei	Dipeptidyl-peptidase 8-like, putative	0.0055	0.0473	0.6752
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0201	0.0832
Onchocerca volvulus		0.0031	0.0201	0.0696
Trichomonas vaginalis	conserved hypothetical protein	0.0031	0.0201	0.0726
Echinococcus granulosus	calcium:calmodulin dependent protein kinase type 1	0.0067	0.0597	0.1568
Echinococcus multilocularis	solute carrier family 22	0.0031	0.0201	0.0529
Echinococcus granulosus	calcium:calmodulin dependent protein kinase type	0.0067	0.0597	0.1568
Toxoplasma gondii	histone lysine methyltransferase SET/SUV39	0.0033	0.0232	0.0351
Toxoplasma gondii	sugar transporter ST1	0.0031	0.0201	0.0305
Trichomonas vaginalis	conserved hypothetical protein	0.0031	0.0201	0.0726
Giardia lamblia	Sugar-proton symporter	0.0031	0.0201	0.346
Trypanosoma brucei	Alpha/beta hydrolase domain-containing protein	0.0013	0.0009	0.0126
Brugia malayi	Sugar transporter family protein	0.0031	0.0201	0.0832
Echinococcus granulosus	solute carrier family 2 facilitated glucose	0.0218	0.2253	0.5919
Echinococcus granulosus	solute carrier family 22	0.0031	0.0201	0.0529
Trichomonas vaginalis	Clan SC, family S28, unassigned serine peptidase	0.0019	0.0077	0.0279
Plasmodium falciparum	lysine--tRNA ligase	0.0049	0.0399	0.0399
Trichomonas vaginalis	Clan SC, family S28, unassigned serine peptidase	0.0019	0.0077	0.0279
Echinococcus granulosus	Sugar transporter ERD6 protein	0.0031	0.0201	0.0529
Treponema pallidum	exodeoxyribonuclease (exoA)	0.0021	0.0097	0.814
Echinococcus granulosus	solute carrier family 22	0.0031	0.0201	0.0529
Trypanosoma cruzi	hexose transporter	0.0067	0.0606	0.8651
Mycobacterium tuberculosis	Probable dicarboxylic acid transport integral membrane protein KgtP (dicarboxylate transporter)	0.0031	0.0201	0.6328
Trichomonas vaginalis	sugar transporter, putative	0.0031	0.0201	0.0726
Echinococcus granulosus	lysyl tRNA synthetase	0.0049	0.0399	0.1047
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0033	0.0232	0.061
Plasmodium vivax	calcium-dependent protein kinase, putative	0.0067	0.0597	0.0597
Mycobacterium tuberculosis	Probable protease II PtrBb [second part] (oligopeptidase B)	0.0013	0.0009	0.0278
Echinococcus granulosus	Lysosomal Pro X carboxypeptidase	0.0359	0.3807	1
Trichomonas vaginalis	ap endonuclease, putative	0.0021	0.0097	0.0348
Trichomonas vaginalis	sugar transporter, putative	0.0031	0.0201	0.0726
Toxoplasma gondii	prolyl-tRNA synthetase (ProRS)	0.0076	0.0701	0.106
Entamoeba histolytica	protein kinase, putative	0.0067	0.0597	1
Plasmodium falciparum	calcium-dependent protein kinase 4	0.0067	0.0597	0.0597
Trichomonas vaginalis	sugar transporter, putative	0.0031	0.0201	0.0726
Trypanosoma brucei	serine peptidase, clan SC, family S9A-like protein	0.0013	0.0009	0.0126
Schistosoma mansoni	hypothetical protein	0.0036	0.0263	0.0691
Entamoeba histolytica	hypothetical protein	0.0036	0.0263	0.4407
Entamoeba histolytica	dipeptidyl-peptidase, putative	0.0013	0.0009	0.0149
Trichomonas vaginalis	sugar transporter, putative	0.0067	0.0606	0.2185
Brugia malayi	Serine carboxypeptidase S28 family protein	0.0019	0.0077	0.032
Echinococcus granulosus	solute carrier family 22	0.0031	0.0201	0.0529
Echinococcus multilocularis	General substrate transporter	0.0187	0.1918	0.5038
Onchocerca volvulus		0.0031	0.0201	0.0696
Loa Loa (eye worm)	hypothetical protein	0.0065	0.0582	0.2404
Brugia malayi	prolyl oligopeptidase family protein	0.0055	0.0473	0.1954
Trypanosoma cruzi	oligopeptidase b	0.0013	0.0009	0.0126
Trichomonas vaginalis	Clan SC, family S28, unassigned serine peptidase	0.0019	0.0077	0.0279
Wolbachia endosymbiont of Brugia malayi	exonuclease III	0.0021	0.0097	0.4797
Schistosoma mansoni	protein kinase	0.0067	0.0597	0.1568
Echinococcus multilocularis	dipeptidyl aminopeptidaseprotein	0.0165	0.1672	0.4393
Schistosoma mansoni	subfamily S9B unassigned peptidase (S09 family)	0.0165	0.1672	0.4393
Trypanosoma cruzi	serine peptidase, Clan SC, Family S9B	0.0055	0.0473	0.6752
Schistosoma mansoni	sugar transporter	0.0031	0.0201	0.0529
Plasmodium falciparum	calcium-dependent protein kinase 3	0.0067	0.0597	0.0597
Echinococcus multilocularis	Lysosomal Pro X carboxypeptidase	0.0359	0.3807	1
Echinococcus granulosus	calcium:calmodulin dependent protein kinase type	0.0067	0.0597	0.1568
Schistosoma mansoni	nuclear transcription factor X-box binding 1 (nfx1)	0.0031	0.0201	0.0529
Schistosoma mansoni	hypothetical protein	0.0218	0.2253	0.5919
Onchocerca volvulus		0.0031	0.0201	0.0696
Trichomonas vaginalis	sugar transporter, putative	0.0031	0.0201	0.0726
Schistosoma mansoni	glucose transport protein	0.0218	0.2253	0.5919
Loa Loa (eye worm)	exodeoxyribonuclease III family protein	0.0021	0.0097	0.0399
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0036	0.0263	0.0691
Trichomonas vaginalis	lysyl-tRNA synthetase, putative	0.0043	0.0333	0.12
Trichomonas vaginalis	set domain proteins, putative	0.0265	0.2775	1
Trichomonas vaginalis	myo-inositol transporter, putative	0.0031	0.0201	0.0726
Brugia malayi	hypothetical protein	0.0042	0.033	0.1362
Trypanosoma brucei	serine peptidase, Clan SC, Family S9B	0.0055	0.0473	0.6752
Trypanosoma cruzi	oligopeptidase B-like protein, putative	0.0013	0.0009	0.0126
Schistosoma mansoni	prolyl oligopeptidase (S09 family)	0.0013	0.0009	0.0023
Leishmania major	dipeptidyl-peptidase 8-like serine peptidase, putative,serine peptidase, Clan SC, Family S9B	0.0055	0.0473	0.6752
Trichomonas vaginalis	sugar transporter, putative	0.0031	0.0201	0.0726
Brugia malayi	hypothetical protein	0.0031	0.0201	0.0832
Echinococcus granulosus	solute carrier family 2 facilitated glucose	0.0218	0.2253	0.5919
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0077	0.032
Trichomonas vaginalis	sugar transporter, putative	0.0031	0.0201	0.0726
Trichomonas vaginalis	Clan SC, family S28, unassigned serine peptidase	0.0019	0.0077	0.0279
Onchocerca volvulus		0.0019	0.0077	0.0248
Mycobacterium ulcerans	lysyl-tRNA synthetase	0.0049	0.0399	1
Leishmania major	oligopeptidase b	0.0013	0.0009	0.0126
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0201	0.0832
Trypanosoma brucei	prolyl oligopeptidase, putative	0.0013	0.0009	0.0126
Schistosoma mansoni	sugar transporter	0.0031	0.0201	0.0529
Trypanosoma brucei	apurinic/apyrimidinic endonuclease, putative	0.0021	0.0097	0.1379
Trichomonas vaginalis	Clan SC, family S28, unassigned serine peptidase	0.0019	0.0077	0.0279
Onchocerca volvulus		0.0033	0.0232	0.0808
Onchocerca volvulus		0.0031	0.0201	0.0696
Entamoeba histolytica	prolyl oligopeptidase family protein	0.0013	0.0009	0.0149
Echinococcus multilocularis	Lysosomal Pro X carboxypeptidase	0.0019	0.0077	0.0203
Plasmodium falciparum	calcium-dependent protein kinase 2	0.0067	0.0597	0.0597
Echinococcus granulosus	dipeptidyl aminopeptidaseprotein	0.0165	0.1672	0.4393
Trichomonas vaginalis	sugar transporter, putative	0.0031	0.0201	0.0726
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0201	0.0832
Echinococcus multilocularis	lysyl tRNA synthetase	0.0049	0.0399	0.1047
Leishmania major	glucose transporter/membrane transporter D2, putative	0.0067	0.0606	0.8651
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0077	0.032
Trichomonas vaginalis	prolylcarboxypeptidase, putative	0.0019	0.0077	0.0279
Plasmodium falciparum	protein kinase 7	0.0615	0.6612	0.6612
Trypanosoma cruzi	glucose transporter, putative	0.0031	0.0201	0.2874
Leishmania major	glucose transporter, lmgt3	0.0067	0.0606	0.8651
Trypanosoma cruzi	putative prolyl carboxypeptidase, putative	0.0019	0.0077	0.1105
Onchocerca volvulus		0.0031	0.0201	0.0696
Echinococcus multilocularis	solute carrier family 2, facilitated glucose	0.0218	0.2253	0.5919
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0201	0.0832
Brugia malayi	hypothetical protein	0.0031	0.0201	0.0832
Trichomonas vaginalis	sugar transporter, putative	0.0031	0.0201	0.0726
Entamoeba histolytica	hypothetical protein	0.0036	0.0263	0.4407
Trypanosoma cruzi	hexose transporter, putative	0.0067	0.0606	0.8651
Trichomonas vaginalis	sugar transporter, putative	0.0031	0.0201	0.0726
Entamoeba histolytica	hypothetical protein	0.0049	0.0399	0.6679
Schistosoma mansoni	glucose transport protein	0.0218	0.2253	0.5919
Echinococcus multilocularis	acylamino acid releasing enzyme	0.0013	0.0009	0.0023
Trypanosoma cruzi	hypothetical protein, conserved	0.0013	0.0009	0.0127
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0201	0.0832
Plasmodium falciparum	calcium-dependent protein kinase 1	0.0067	0.0597	0.0597
Loa Loa (eye worm)	hypothetical protein	0.0013	0.0009	0.0037
Onchocerca volvulus		0.0031	0.0201	0.0696
Plasmodium vivax	SET domain protein, putative	0.0033	0.0232	0.0232
Loa Loa (eye worm)	calcium/calmodulin-dependent protein kinase ID	0.0067	0.0597	0.2465
Leishmania major	glucose transporter, lmgt2	0.0067	0.0606	0.8651
Loa Loa (eye worm)	hypothetical protein	0.0065	0.0582	0.2404
Brugia malayi	Bifunctional aminoacyl-tRNA synthetase	0.0065	0.0582	0.2404
Trypanosoma cruzi	hexose transporter, putative	0.0067	0.0606	0.8651
Trichomonas vaginalis	sugar transporter, putative	0.0031	0.0201	0.0726
Echinococcus granulosus	prolyl endopeptidase	0.0013	0.0009	0.0023
Trichomonas vaginalis	conserved hypothetical protein	0.0031	0.0201	0.0726
Brugia malayi	Pre-SET motif family protein	0.0033	0.0232	0.0959
Leishmania major	myo-inositol/proton symporter (MIT)	0.0031	0.0201	0.2874
Loa Loa (eye worm)	hypothetical protein	0.0013	0.0009	0.0037
Trypanosoma brucei	glucose transporter, putative	0.0067	0.0606	0.8651
Echinococcus multilocularis	Dipeptidyl peptidase 9	0.0055	0.0473	0.1243
Wolbachia endosymbiont of Brugia malayi	major facilitator superfamily permease	0.0031	0.0201	1
Toxoplasma gondii	sugar transporter ST3	0.0031	0.0201	0.0305
Toxoplasma gondii	calcium-dependent protein kinase CDPK2B	0.0067	0.0597	0.0903
Trichomonas vaginalis	sugar transporter, putative	0.0031	0.0201	0.0726
Toxoplasma gondii	lysine-tRNA ligase	0.0049	0.0399	0.0603
Echinococcus multilocularis	prolyl endopeptidase	0.0013	0.0009	0.0023
Schistosoma mansoni	serine/threonine protein kinase	0.0067	0.0597	0.1568
Trichomonas vaginalis	sugar transporter, putative	0.0031	0.0201	0.0726
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0033	0.0232	0.061
Brugia malayi	Cam kinase protein 1	0.0067	0.0597	0.2465
Trichomonas vaginalis	lysosomal pro-X carboxypeptidase, putative	0.0019	0.0077	0.0279
Trichomonas vaginalis	Clan SC, family S28, unassigned serine peptidase	0.0019	0.0077	0.0279
Toxoplasma gondii	hypothetical protein	0.0013	0.0009	0.0013
Mycobacterium leprae	Possible lysyl-tRNA synthetase 2 LysX	0.0049	0.0399	0.6849
Trichomonas vaginalis	Clan SC, family S28, unassigned serine peptidase	0.0019	0.0077	0.0279
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0201	0.0832
Trichomonas vaginalis	sugar transporter, putative	0.0031	0.0201	0.0726
Giardia lamblia	Prolyl-tRNA synthetase	0.0065	0.0582	1
Schistosoma mansoni	ap endonuclease	0.0021	0.0097	0.0254
Trichomonas vaginalis	sugar transporter, putative	0.0031	0.0201	0.0726
Onchocerca volvulus		0.0031	0.0201	0.0696
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0201	0.0832
Onchocerca volvulus		0.0031	0.0201	0.0696
Entamoeba histolytica	serine carboxypeptidase (S28) family protein	0.0019	0.0077	0.1298
Mycobacterium ulcerans	sugar transporter	0.0031	0.0201	0.5052
Onchocerca volvulus		0.0265	0.2775	1
Entamoeba histolytica	serine carboxypeptidase (S28) family protein	0.0019	0.0077	0.1298
Trichomonas vaginalis	Clan SC, family S28, unassigned serine peptidase	0.0019	0.0077	0.0279
Toxoplasma gondii	dipeptidyl peptidase iv (dpp iv) n-terminal region domain-containing protein	0.0055	0.0473	0.0716
Echinococcus multilocularis	calcium:calmodulin dependent protein kinase type	0.0067	0.0597	0.1568
Entamoeba histolytica	prolyl oligopeptidase family protein	0.0013	0.0009	0.0149
Plasmodium vivax	CDK-related protein kinase 6, putative	0.0923	1	1
Schistosoma mansoni	histone-lysine n-methyltransferase suv9	0.0033	0.0232	0.061
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0201	0.0832
Trichomonas vaginalis	sugar transporter, putative	0.0031	0.0201	0.0726
Echinococcus multilocularis	solute carrier family 2 facilitated glucose	0.0218	0.2253	0.5919
Schistosoma mansoni	prolyl oligopeptidase (S09 family)	0.0013	0.0009	0.0023
Loa Loa (eye worm)	pre-SET domain-containing protein family protein	0.0233	0.2421	1
Trichomonas vaginalis	sugar transporter, putative	0.0031	0.0201	0.0726
Trichomonas vaginalis	Clan SC, family S33, methylesterase-like serine peptidase	0.0013	0.0009	0.0032
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0201	0.0832
Trichomonas vaginalis	conserved hypothetical protein	0.0031	0.0201	0.0726
Brugia malayi	Calcium/calmodulin-dependent protein kinase type II alpha chain	0.0067	0.0597	0.2465
Plasmodium falciparum	hexose transporter	0.0218	0.2253	0.2253
Brugia malayi	prolyl oligopeptidase family protein	0.0013	0.0009	0.0037
Trichomonas vaginalis	sugar transporter, putative	0.0031	0.0201	0.0726
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0201	0.0832
Giardia lamblia	Alanyl dipeptidyl peptidase	0.0013	0.0009	0.0152
Plasmodium vivax	calcium-dependent protein kinase 4, putative	0.0067	0.0597	0.0597
Mycobacterium tuberculosis	Probable peptidase	0.0013	0.0009	0.0278
Leishmania major	protein kinase, putative	0.0067	0.0597	0.8517
Trichomonas vaginalis	prolylcarboxypeptidase, putative	0.0019	0.0077	0.0279
Leishmania major	glucose transporter, lmgt1	0.0067	0.0606	0.8651
Brugia malayi	hypothetical protein	0.0031	0.0201	0.0832
Onchocerca volvulus		0.0031	0.0201	0.0696
Trypanosoma brucei	glucose transporter, putative	0.0067	0.0606	0.8651
Trichomonas vaginalis	conserved hypothetical protein	0.0031	0.0201	0.0726
Entamoeba histolytica	hypothetical protein	0.0036	0.0263	0.4407
Trichomonas vaginalis	sugar transporter, putative	0.0031	0.0201	0.0726
Schistosoma mansoni	ap endonuclease	0.0021	0.0097	0.0254
Loa Loa (eye worm)	sugar transporter	0.0218	0.2253	0.9306
Mycobacterium ulcerans	exodeoxyribonuclease III protein XthA	0.0021	0.0097	0.2424
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0232	0.0959
Trichomonas vaginalis	sugar transporter, putative	0.0031	0.0201	0.0726
Trypanosoma cruzi	hexose transporter, putative	0.0037	0.027	0.386
Mycobacterium leprae	Probable lysyl-tRNA synthase LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase)	0.0041	0.0318	0.5469
Mycobacterium ulcerans	prolyl-tRNA synthetase	0.0023	0.0119	0.2978
Trypanosoma cruzi	serine carboxypeptidase S28, putative	0.0019	0.0077	0.1105
Giardia lamblia	Thymus-specific serine protease precursor	0.0019	0.0077	0.1331
Trichomonas vaginalis	conserved hypothetical protein	0.0019	0.0077	0.0279
Leishmania major	hypothetical protein, conserved	0.0031	0.0201	0.2874
Giardia lamblia	Alanyl dipeptidyl peptidase	0.0013	0.0009	0.0152
Mycobacterium ulcerans	sugar-transport integral membrane protein SugI	0.0031	0.0201	0.5052
Trichomonas vaginalis	lysyl-tRNA synthetase, putative	0.0049	0.0399	0.1437
Trypanosoma brucei	myo-inositol/proton symporter (MIT)	0.0031	0.0201	0.2874
Schistosoma mansoni	family S28 unassigned peptidase (S28 family)	0.0359	0.3807	1
Echinococcus granulosus	Lysosomal Pro X carboxypeptidase	0.0019	0.0077	0.0203

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

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Bibliographic References

No literature references available for this target.

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Detailed information for compound 763693