TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 424.533 | Formula: C25H32N2O4
H donors: 0 H acceptors: 2 LogP: 3.97 Rotable bonds: 9
Rule of 5 violations (Lipinski): 1
SMILES: CCOC(=O)C1(CCN(CC1)C(=O)c1ccc(cc1)N(C)C)Cc1ccc(cc1)OC
InChi: 1S/C25H32N2O4/c1-5-31-24(29)25(18-19-6-12-22(30-4)13-7-19)14-16-27(17-15-25)23(28)20-8-10-21(11-9-20)26(2)3/h6-13H,5,14-18H2,1-4H3
InChiKey: ZMUFZNXKPUNZAS-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Schistosoma mansoni	glucose transporter	0.0031	0.0204	0.0894
Trichomonas vaginalis	sugar transport protein, putative	0.0031	0.0204	0.0894
Echinococcus multilocularis	COUP TF:Svp nuclear hormone receptor	0.0021	0.01	0.0202
Loa Loa (eye worm)	hypothetical protein	0.02	0.2061	0.9137
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0021	0.01	0.0443
Trichomonas vaginalis	lysyl-tRNA synthetase, putative	0.0043	0.0335	0.1477
Onchocerca volvulus		0.0031	0.0204	0.053
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0035	0.0254	0.1115
Loa Loa (eye worm)	bifunctional aminoacyl-tRNA synthetase	0.0027	0.0162	0.0719
Trypanosoma cruzi	hexose transporter	0.0068	0.0609	0.8656
Plasmodium falciparum	hexose transporter	0.0218	0.2255	0.2253
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-1	0.0021	0.01	0.0443
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0039	0.0173
Toxoplasma gondii	calcium-dependent protein kinase CDPK3	0.0067	0.06	0.0903
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0021	0.01	0.0202
Schistosoma mansoni	protein kinase	0.0067	0.0599	0.2648
Trypanosoma brucei	threonyl-tRNA synthetase, putative	0.0012	0.0003	0.0037
Brugia malayi	Nuclear hormone receptor-like 1	0.0021	0.01	0.0443
Echinococcus granulosus	calcium:calmodulin dependent protein kinase type	0.0067	0.0599	0.1239
Loa Loa (eye worm)	hypothetical protein	0.0021	0.01	0.0443
Trichomonas vaginalis	CAMK family protein kinase	0.0067	0.0599	0.2648
Echinococcus granulosus	calcium:calmodulin dependent protein kinase type 1	0.0067	0.0599	0.1239
Schistosoma mansoni	glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs)	0.0065	0.0584	0.2583
Trypanosoma brucei	calcium/calmodulin-dependent protein kinase, putative	0.0067	0.0599	0.8523
Brugia malayi	Cam kinase protein 1	0.0067	0.0599	0.2657
Trypanosoma brucei	THT1 - hexose transporter, putative	0.0068	0.0609	0.8656
Onchocerca volvulus	Bile acid receptor homolog	0.02	0.2061	1
Giardia lamblia	Hexose transporter	0.0031	0.0204	0.346
Loa Loa (eye worm)	glycyl-tRNA synthetase	0.0012	0.0003	0.0011
Trichomonas vaginalis	D-aminoacylase, putative	0.0035	0.0254	0.1115
Onchocerca volvulus		0.0031	0.0204	0.053
Brugia malayi	Major Facilitator Superfamily protein	0.0031	0.0204	0.0904
Echinococcus multilocularis	neuropeptide receptor A26	0.0452	0.482	1
Plasmodium falciparum	proline--tRNA ligase	0.0076	0.0703	0.0701
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0021	0.01	0.0202
Echinococcus granulosus	calcium:calmodulin dependent protein kinase type	0.0067	0.0599	0.1239
Brugia malayi	nuclear receptor NHR-88	0.0021	0.01	0.0443
Toxoplasma gondii	sugar transporter ST1	0.0031	0.0204	0.0305
Trichomonas vaginalis	conserved hypothetical protein	0.0031	0.0204	0.0894
Echinococcus granulosus	solute carrier family 2 facilitated glucose	0.0218	0.2255	0.4677
Trichomonas vaginalis	sugar transporter, putative	0.0031	0.0204	0.0894
Schistosoma mansoni	nuclear transcription factor X-box binding 1 (nfx1)	0.0031	0.0204	0.0894
Trichomonas vaginalis	sugar transporter, putative	0.0031	0.0204	0.0894
Schistosoma mansoni	glucose transport protein	0.0218	0.2255	1
Trichomonas vaginalis	sugar transporter, putative	0.0031	0.0204	0.0894
Trypanosoma brucei	hypothetical protein, conserved	0.0035	0.0254	0.361
Trypanosoma brucei	glucose transporter, putative	0.0068	0.0609	0.8656
Giardia lamblia	Prolyl-tRNA synthetase	0.0065	0.0584	1
Loa Loa (eye worm)	hypothetical protein	0.0065	0.0584	0.2591
Echinococcus granulosus	calcium dependent protein kinase	0.0063	0.0554	0.1145
Loa Loa (eye worm)	nuclear Hormone Receptor family member	0.0021	0.01	0.0443
Leishmania major	myo-inositol/proton symporter (MIT)	0.0031	0.0204	0.29
Brugia malayi	Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative	0.0035	0.0254	0.1125
Brugia malayi	photoreceptor-specific nuclear receptor	0.0021	0.01	0.0443
Schistosoma mansoni	thyroid hormone receptor	0.0021	0.01	0.0432
Onchocerca volvulus	Putative transporter	0.0031	0.0204	0.053
Leishmania major	threonyl-tRNA synthetase, putative	0.0012	0.0003	0.0037
Echinococcus granulosus	solute carrier family 2 facilitated glucose	0.0218	0.2255	0.4677
Mycobacterium ulcerans	lysyl-tRNA synthetase	0.0049	0.0401	1
Schistosoma mansoni	FTZ-F1 nuclear receptor-like protein	0.0021	0.01	0.0432
Plasmodium falciparum	lysine--tRNA ligase	0.0049	0.0401	0.0399
Trichomonas vaginalis	D-aminoacylase, putative	0.0035	0.0254	0.1115
Trichomonas vaginalis	conserved hypothetical protein	0.0068	0.0609	0.269
Echinococcus multilocularis	solute carrier family 22	0.0031	0.0204	0.0418
Loa Loa (eye worm)	hypothetical protein	0.0021	0.01	0.0443
Trypanosoma brucei	THT1 - hexose transporter, putative	0.0068	0.0609	0.8656
Echinococcus multilocularis	calcium:calmodulin dependent protein kinase type	0.0067	0.0599	0.1239
Onchocerca volvulus		0.0031	0.0204	0.053
Loa Loa (eye worm)	hypothetical protein	0.0021	0.01	0.0443
Echinococcus multilocularis	nuclear receptor subfamily 1 group D	0.0016	0.0039	0.0076
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0254	0.1125
Trypanosoma cruzi	hexose transporter, putative	0.0068	0.0609	0.8656
Trichomonas vaginalis	sugar transporter, putative	0.0068	0.0609	0.269
Echinococcus multilocularis	solute carrier family 2 facilitated glucose	0.0218	0.2255	0.4677
Chlamydia trachomatis	proline--tRNA ligase	0.0023	0.0121	0.2978
Loa Loa (eye worm)	threonyl-tRNA synthetase	0.0012	0.0003	0.0011
Plasmodium vivax	calcium-dependent protein kinase 4, putative	0.0067	0.06	0.0597
Brugia malayi	Major Facilitator Superfamily protein	0.0031	0.0204	0.0904
Onchocerca volvulus		0.0035	0.0254	0.0785
Trichomonas vaginalis	sugar transporter, putative	0.0031	0.0204	0.0894
Loa Loa (eye worm)	nuclear hormone receptor-like 1	0.0016	0.0039	0.0173
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0254	0.1125
Echinococcus multilocularis	solute carrier family 22	0.0031	0.0204	0.0418
Echinococcus multilocularis	solute carrier family 22	0.0031	0.0204	0.0418
Brugia malayi	Bifunctional aminoacyl-tRNA synthetase	0.0065	0.0584	0.2591
Echinococcus granulosus	synaptic vesicle 2 protein	0.0031	0.0204	0.0418
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0021	0.01	0.0443
Echinococcus multilocularis	FTZ F1 nuclear receptor protein	0.0021	0.01	0.0202
Trichomonas vaginalis	myo-inositol transporter, putative	0.0031	0.0204	0.0894
Trypanosoma cruzi	hexose transporter, putative	0.0068	0.0609	0.8656
Toxoplasma gondii	prolyl-tRNA synthetase (ProRS)	0.0076	0.0703	0.106
Echinococcus multilocularis	solute carrier family 2 facilitated glucose	0.0218	0.2255	0.4677
Plasmodium falciparum	mitogen-activated protein kinase 2	0.0352	0.3726	0.3724
Mycobacterium tuberculosis	Probable conserved integral membrane transport protein	0.0031	0.0204	0.0865
Loa Loa (eye worm)	beta-LACTamase domain containing family member	0.0035	0.0254	0.1125
Brugia malayi	major facilitator superfamily protein	0.0031	0.0204	0.0904
Schistosoma mansoni	hypothetical protein	0.0165	0.1673	0.7413
Trichomonas vaginalis	sugar transporter, putative	0.0031	0.0204	0.0894
Echinococcus multilocularis	FTZ F1 alpha	0.0021	0.01	0.0202
Trichomonas vaginalis	sugar transporter, putative	0.0031	0.0204	0.0894
Toxoplasma gondii	protein kinase, putative	0.0616	0.6613	1
Plasmodium vivax	mitogen-activated protein kinase 2, putative	0.0352	0.3726	0.3724
Trypanosoma brucei	glucose transporter, putative	0.0068	0.0609	0.8656
Trichomonas vaginalis	glucose transporter, putative	0.0068	0.0609	0.269
Brugia malayi	Nuclear hormone receptor family member nhr-49	0.0021	0.01	0.0443
Leishmania major	prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative	0.0076	0.0703	1
Brugia malayi	hypothetical protein	0.0016	0.0039	0.0173
Mycobacterium ulcerans	sugar transporter	0.0031	0.0204	0.5084
Leishmania major	glucose transporter, lmgt3	0.0068	0.0609	0.8656
Brugia malayi	steroid hormone receptor	0.0021	0.01	0.0443
Echinococcus multilocularis	solute carrier family 2, facilitated glucose	0.0218	0.2255	0.4677
Trichomonas vaginalis	prolyl-tRNA synthetase, putative	0.0065	0.0584	0.2583
Echinococcus granulosus	solute carrier family 22	0.0031	0.0204	0.0418
Trichomonas vaginalis	sugar transporter, putative	0.0031	0.0204	0.0894
Mycobacterium leprae	Probable lipase LipE	0.0035	0.0254	0.4317
Leishmania major	lysyl-tRNA synthetase, putative	0.0049	0.0401	0.5705
Schistosoma mansoni	thyroid hormone receptor	0.0021	0.01	0.0432
Echinococcus granulosus	General substrate transporter	0.0187	0.192	0.398
Onchocerca volvulus		0.0031	0.0204	0.053
Plasmodium vivax	sugar transporter, putative	0.0031	0.0204	0.0201
Trichomonas vaginalis	sugar transporter, putative	0.0031	0.0204	0.0894
Loa Loa (eye worm)	calcium/calmodulin-dependent protein kinase ID	0.0067	0.0599	0.2657
Toxoplasma gondii	ABC1 family protein	0.0035	0.0254	0.038
Trypanosoma cruzi	threonyl-tRNA synthetase, putative	0.0012	0.0003	0.0037
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0204	0.0904
Mycobacterium tuberculosis	Probable hydrolase	0.0035	0.0254	0.1079
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0254	0.1125
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0204	0.0904
Onchocerca volvulus		0.0031	0.0204	0.053
Mycobacterium tuberculosis	Probable lipase LipE	0.0035	0.0254	0.1079
Plasmodium falciparum	calcium-dependent protein kinase 2	0.0067	0.06	0.0597
Plasmodium vivax	calcium-dependent protein kinase, putative	0.0067	0.06	0.0597
Loa Loa (eye worm)	sugar transporter	0.0218	0.2255	1
Trichomonas vaginalis	sugar transporter, putative	0.0031	0.0204	0.0894
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0039	0.0173
Echinococcus multilocularis	solute carrier family 22	0.0031	0.0204	0.0418
Leishmania major	glucose transporter, lmgt1	0.0068	0.0609	0.8656
Mycobacterium ulcerans	glycyl-tRNA synthetase	0.0012	0.0003	0.0065
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0021	0.01	0.0443
Trichomonas vaginalis	sugar transporter, putative	0.0031	0.0204	0.0894
Mycobacterium tuberculosis	Conserved protein	0.0035	0.0254	0.1079
Onchocerca volvulus		0.0031	0.0204	0.053
Mycobacterium tuberculosis	Conserved protein	0.0035	0.0254	0.1079
Trypanosoma brucei	bifunctional aminoacyl-tRNA synthetase, putative	0.0076	0.0703	1
Trichomonas vaginalis	sugar transporter, putative	0.0031	0.0204	0.0894
Trichomonas vaginalis	sugar transporter, putative	0.0031	0.0204	0.0894
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0021	0.01	0.0432
Trypanosoma cruzi	threonyl-tRNA synthetase, putative	0.0012	0.0003	0.0037
Loa Loa (eye worm)	hypothetical protein	0.0067	0.0599	0.2657
Trypanosoma cruzi	glucose transporter, putative	0.0031	0.0204	0.29
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0039	0.0173
Mycobacterium ulcerans	prolyl-tRNA synthetase	0.0023	0.0121	0.3023
Schistosoma mansoni	coup transcription factor	0.0021	0.01	0.0432
Mycobacterium ulcerans	lysyl-tRNA synthetase	0.0049	0.0401	1
Loa Loa (eye worm)	hypothetical protein	0.0053	0.045	0.1996
Giardia lamblia	Sugar-proton symporter	0.0031	0.0204	0.346
Toxoplasma gondii	lysine-tRNA ligase	0.0049	0.0401	0.0603
Trichomonas vaginalis	sugar transporter, putative	0.0031	0.0204	0.0894
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0204	0.0904
Plasmodium falciparum	calcium-dependent protein kinase 4	0.0067	0.06	0.0597
Loa Loa (eye worm)	major facilitator superfamily transporter	0.0031	0.0204	0.0904
Echinococcus granulosus	glutamyl tRNA synthetase cytoplasmic	0.0065	0.0584	0.1208
Echinococcus multilocularis	lysyl tRNA synthetase	0.0049	0.0401	0.0827
Schistosoma mansoni	ecdysone-induced protein 78c (dr-78)	0.0016	0.0039	0.0161
Echinococcus multilocularis	calcium:calmodulin dependent protein kinase type	0.0067	0.0599	0.1239
Mycobacterium ulcerans	fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE	0.0035	0.0254	0.6328
Brugia malayi	Nuclear hormone receptor-like 1	0.0016	0.0039	0.0173
Schistosoma mansoni	sugar transporter	0.0031	0.0204	0.0894
Loa Loa (eye worm)	CAMK/CAMK2 protein kinase	0.0067	0.0599	0.2657
Loa Loa (eye worm)	hypothetical protein	0.0021	0.01	0.0443
Onchocerca volvulus		0.0031	0.0204	0.053
Brugia malayi	Steroid receptor seven-up type 2	0.0021	0.01	0.0443
Trichomonas vaginalis	D-aminoacylase, putative	0.0035	0.0254	0.1115
Mycobacterium tuberculosis	Probable esterase/lipase LipP	0.0035	0.0254	0.1079
Brugia malayi	hypothetical protein	0.0031	0.0204	0.0904
Loa Loa (eye worm)	beta-lactamase	0.0035	0.0254	0.1125
Trypanosoma cruzi	lysyl-tRNA synthetase, putative	0.0049	0.0401	0.5705
Schistosoma mansoni	protein kinase	0.0067	0.0599	0.2648
Loa Loa (eye worm)	major facilitator superfamily transporter	0.0031	0.0204	0.0904
Leishmania major	prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative	0.0076	0.0703	1
Schistosoma mansoni	nuclear receptor 2DBD-gamma	0.0021	0.01	0.0432
Schistosoma mansoni	glucose transport protein	0.0218	0.2255	1
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0254	0.1125
Trypanosoma brucei	glucose transporter, putative	0.0068	0.0609	0.8656
Entamoeba histolytica	prolyl-tRNA synthetase, putative	0.0065	0.0584	0.9752
Trichomonas vaginalis	sugar transporter, putative	0.0031	0.0204	0.0894
Trypanosoma brucei	glucose transporter, putative	0.0068	0.0609	0.8656
Mycobacterium tuberculosis	Probable lipase LipD	0.0035	0.0254	0.1079
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0204	0.0904
Trypanosoma brucei	glucose transporter 1E	0.0068	0.0609	0.8656
Brugia malayi	Sugar transporter family protein	0.0031	0.0204	0.0904
Trypanosoma brucei	glycyl-tRNA synthetase, putative	0.0012	0.0003	0.0037
Trichomonas vaginalis	sugar transporter, putative	0.0031	0.0204	0.0894
Trichomonas vaginalis	sugar transporter, putative	0.0031	0.0204	0.0894
Toxoplasma gondii	sugar transporter ST2	0.0031	0.0204	0.0305
Onchocerca volvulus		0.0031	0.0204	0.053
Schistosoma mansoni	lysyl-tRNA synthetase	0.0049	0.0401	0.1769
Echinococcus multilocularis	beta LACTamase domain containing family member	0.0035	0.0254	0.0522
Echinococcus granulosus	solute carrier family 22	0.0031	0.0204	0.0418
Trypanosoma brucei	glucose transporter, putative	0.0068	0.0609	0.8656
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0204	0.0904
Onchocerca volvulus		0.0031	0.0204	0.053
Trypanosoma brucei	myo-inositol/proton symporter (MIT)	0.0031	0.0204	0.29
Echinococcus granulosus	FTZ F1 alpha	0.0021	0.01	0.0202
Trichomonas vaginalis	lysyl-tRNA synthetase, putative	0.0049	0.0401	0.1769
Leishmania major	hypothetical protein, conserved	0.0031	0.0204	0.29
Trichomonas vaginalis	conserved hypothetical protein	0.0031	0.0204	0.0894
Brugia malayi	Nuclear hormone receptor family member nhr-40	0.0021	0.01	0.0443
Loa Loa (eye worm)	hypothetical protein	0.0049	0.0401	0.1778
Wolbachia endosymbiont of Brugia malayi	major facilitator superfamily permease	0.0031	0.0204	1
Trypanosoma brucei	sugar transporter, putative	0.0031	0.0204	0.29
Echinococcus multilocularis	geminin	0.0165	0.1673	0.3467
Treponema pallidum	prolyl-tRNA synthetase	0.0023	0.0121	1
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0204	0.0904
Brugia malayi	bifunctional aminoacyl-tRNA synthetase	0.0065	0.0584	0.2591
Trypanosoma cruzi	prolyl-tRNA synthetase, putative	0.0076	0.0703	1
Mycobacterium ulcerans	beta-lactamase	0.0035	0.0254	0.6328
Trichomonas vaginalis	sugar transporter, putative	0.0031	0.0204	0.0894
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0204	0.0904
Schistosoma mansoni	sugar transporter	0.0031	0.0204	0.0894
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-40	0.0021	0.01	0.0443
Mycobacterium leprae	Probable prolyl tRNA synthetase ProS	0.0065	0.0584	1
Trichomonas vaginalis	sugar transporter, putative	0.0068	0.0609	0.269
Trichomonas vaginalis	sugar transporter, putative	0.0031	0.0204	0.0894
Leishmania major	glucose transporter, lmgt2	0.0068	0.0609	0.8656
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-14	0.0021	0.01	0.0443
Echinococcus multilocularis	calcium:calmodulin dependent protein kinase type	0.0067	0.0599	0.1239
Schistosoma mansoni	nuclear hormone receptor nor-1/nor-2	0.0021	0.01	0.0432
Trypanosoma cruzi	sugar transporter, putative	0.0031	0.0204	0.29
Echinococcus multilocularis	General substrate transporter	0.0187	0.192	0.398
Brugia malayi	Major Facilitator Superfamily protein	0.0031	0.0204	0.0904
Trichomonas vaginalis	esterase, putative	0.0035	0.0254	0.1115
Trichomonas vaginalis	sugar transporter, putative	0.0031	0.0204	0.0894
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0021	0.01	0.0202
Trichomonas vaginalis	penicillin-binding protein, putative	0.0035	0.0254	0.1115
Schistosoma mansoni	hypothetical protein	0.0165	0.1673	0.7413
Trichomonas vaginalis	glucose transporter, putative	0.0068	0.0609	0.269
Trichomonas vaginalis	sugar transporter, putative	0.0031	0.0204	0.0894
Brugia malayi	lysyl-tRNA synthetase	0.0049	0.0401	0.1778
Echinococcus granulosus	geminin	0.0165	0.1673	0.3467
Schistosoma mansoni	photoreceptor-specific nuclear receptor related	0.0021	0.01	0.0432
Brugia malayi	threonyl-tRNA synthetase, cytoplasmic	0.0012	0.0003	0.0011
Chlamydia trachomatis	lysine--tRNA ligase	0.0049	0.0401	1
Echinococcus multilocularis	calcium dependent protein kinase	0.0063	0.0554	0.1145
Echinococcus multilocularis	hepatocyte nuclear factor 4 alpha	0.0021	0.01	0.0202
Toxoplasma gondii	sugar transporter ST3	0.0031	0.0204	0.0305
Echinococcus multilocularis	Nuclear hormone receptor family member nhr 41	0.0021	0.01	0.0202
Brugia malayi	hypothetical protein	0.0031	0.0204	0.0904
Trichomonas vaginalis	conserved hypothetical protein	0.0031	0.0204	0.0894
Schistosoma mansoni	protein kinase	0.0067	0.0599	0.2648
Toxoplasma gondii	transporter, major facilitator family protein	0.0031	0.0204	0.0305
Schistosoma mansoni	Tr4/Tr2 (homologue)	0.0021	0.01	0.0432
Echinococcus granulosus	solute carrier family 2 facilitated glucose	0.0218	0.2255	0.4677
Echinococcus multilocularis	thyroid hormone receptor alpha	0.0021	0.01	0.0202
Onchocerca volvulus		0.0035	0.0254	0.0785
Brugia malayi	nuclear hormone receptor	0.0021	0.01	0.0443
Echinococcus multilocularis	neuropeptide s receptor	0.0452	0.482	1
Schistosoma mansoni	serine/threonine protein kinase	0.0067	0.0599	0.2648
Trypanosoma brucei	glucose transporter, putative	0.0068	0.0609	0.8656
Trypanosoma cruzi	prolyl-tRNA synthetase, putative	0.0076	0.0703	1
Trichomonas vaginalis	sugar transporter, putative	0.0031	0.0204	0.0894
Plasmodium vivax	lysine--tRNA ligase, putative	0.0049	0.0401	0.0399
Onchocerca volvulus		0.0031	0.0204	0.053
Trichomonas vaginalis	conserved hypothetical protein	0.0068	0.0609	0.269
Schistosoma mansoni	steroid hormone receptor ad4bp	0.0021	0.01	0.0432
Mycobacterium tuberculosis	Conserved protein	0.0035	0.0254	0.1079
Schistosoma mansoni	nuclear hormone receptor	0.0021	0.01	0.0432
Onchocerca volvulus		0.0035	0.0254	0.0785
Echinococcus granulosus	solute carrier family 22	0.0031	0.0204	0.0418
Brugia malayi	Calcium/calmodulin-dependent protein kinase type II alpha chain	0.0067	0.0599	0.2657
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0021	0.01	0.0443
Trichomonas vaginalis	sugar transporter, putative	0.0031	0.0204	0.0894
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0021	0.01	0.0443
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0021	0.01	0.0202
Plasmodium falciparum	protein kinase 7	0.0616	0.6613	0.6612
Toxoplasma gondii	calcium-dependent protein kinase CDPK2B	0.0067	0.06	0.0903
Brugia malayi	Nuclear hormone receptor family member nhr-41	0.0021	0.01	0.0443
Plasmodium vivax	proline--tRNA ligase, putative	0.0076	0.0703	0.0701
Mycobacterium leprae	Probable lysyl-tRNA synthase LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase)	0.0041	0.0321	0.5469
Onchocerca volvulus		0.0031	0.0204	0.053
Plasmodium vivax	hypothetical protein, conserved	0.0035	0.0254	0.0251
Trichomonas vaginalis	penicillin-binding protein, putative	0.0035	0.0254	0.1115
Trichomonas vaginalis	sugar transporter, putative	0.0031	0.0204	0.0894
Mycobacterium tuberculosis	Probable esterase LipL	0.0035	0.0254	0.1079
Trichomonas vaginalis	conserved hypothetical protein	0.0218	0.2255	1
Mycobacterium ulcerans	esterase/lipase LipP	0.0035	0.0254	0.6328
Toxoplasma gondii	cell-cycle-associated protein kinase MAPK, putative	0.0352	0.3726	0.5632
Leishmania major	glucose transporter/membrane transporter D2, putative	0.0068	0.0609	0.8656
Brugia malayi	ecdysteroid receptor	0.02	0.2061	0.9137
Trichomonas vaginalis	sugar transporter, putative	0.0031	0.0204	0.0894
Echinococcus granulosus	neuropeptide receptor A26	0.0452	0.482	1
Entamoeba histolytica	protein kinase, putative	0.0067	0.0599	1
Mycobacterium ulcerans	hypothetical protein	0.0035	0.0254	0.6328
Echinococcus granulosus	Sugar transporter ERD6 protein	0.0031	0.0204	0.0418
Loa Loa (eye worm)	steroid hormone receptor	0.0021	0.01	0.0443
Mycobacterium tuberculosis	Lysyl-tRNA synthetase 1 LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase)	0.0041	0.0321	0.1366
Echinococcus granulosus	hepatocyte nuclear factor 4 alpha	0.0021	0.01	0.0202
Echinococcus granulosus	COUP TF:Svp nuclear hormone receptor	0.0021	0.01	0.0202
Trichomonas vaginalis	sugar transporter, putative	0.0031	0.0204	0.0894
Plasmodium vivax	hexose transporter	0.0218	0.2255	0.2253
Plasmodium falciparum	major facilitator superfamily domain-containing protein, putative	0.0031	0.0204	0.0201
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-41	0.0021	0.01	0.0443
Trichomonas vaginalis	sugar transporter, putative	0.0031	0.0204	0.0894
Brugia malayi	Nuclear hormone receptor-like 1	0.0016	0.0039	0.0173
Echinococcus granulosus	lysyl tRNA synthetase	0.0049	0.0401	0.0827
Brugia malayi	beta-lactamase family protein	0.0035	0.0254	0.1125
Trichomonas vaginalis	glucose transporter, putative	0.0031	0.0204	0.0894
Onchocerca volvulus		0.0031	0.0204	0.053
Schistosoma mansoni	lysyl-tRNA synthetase	0.0049	0.0401	0.1769
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0003	0.0011
Brugia malayi	hypothetical protein	0.0016	0.0039	0.0173
Mycobacterium ulcerans	threonyl-tRNA synthetase	0.0012	0.0003	0.0065
Echinococcus multilocularis	Sugar transporter ERD6 protein	0.0031	0.0204	0.0418
Leishmania major	hypothetical protein, conserved	0.0035	0.0254	0.361
Trichomonas vaginalis	sugar transporter, putative	0.0031	0.0204	0.0894
Giardia lamblia	Lysyl-tRNA synthetase	0.0049	0.0401	0.6849
Trypanosoma cruzi	hexose transporter, putative	0.0068	0.0609	0.8656
Plasmodium falciparum	calcium-dependent protein kinase 1	0.0067	0.06	0.0597
Schistosoma mansoni	glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs)	0.0065	0.0584	0.2583
Schistosoma mansoni	RAR-like nuclear receptor	0.0021	0.01	0.0432
Trichomonas vaginalis	sugar transporter, putative	0.0031	0.0204	0.0894
Brugia malayi	nuclear receptor RXR	0.0016	0.0039	0.0173
Mycobacterium leprae	Possible lysyl-tRNA synthetase 2 LysX	0.0049	0.0401	0.6849
Brugia malayi	Nuclear hormone receptor family member nhr-31	0.0021	0.01	0.0443
Echinococcus granulosus	FTZ F1 nuclear receptor protein	0.0021	0.01	0.0202
Trichomonas vaginalis	sugar transporter, putative	0.0031	0.0204	0.0894
Echinococcus multilocularis	glutamyl tRNA synthetase cytoplasmic	0.0065	0.0584	0.1208
Onchocerca volvulus		0.0031	0.0204	0.053
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-31	0.0021	0.01	0.0443
Onchocerca volvulus		0.0031	0.0204	0.053
Echinococcus granulosus	Nuclear hormone receptor family member nhr 41	0.0021	0.01	0.0202
Trypanosoma cruzi	hexose transporter, putative	0.0037	0.0273	0.3882
Mycobacterium ulcerans	lipase LipD	0.0035	0.0254	0.6328
Trichomonas vaginalis	sugar transporter, putative	0.0068	0.0609	0.269
Brugia malayi	Sugar transporter family protein	0.0031	0.0204	0.0904
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0254	0.1125
Trypanosoma brucei	glucose transporter 2A	0.0068	0.0609	0.8656
Mycobacterium tuberculosis	Probable conserved lipoprotein	0.0035	0.0254	0.1079
Trichomonas vaginalis	sugar transporter, putative	0.0031	0.0204	0.0894
Trypanosoma brucei	glucose transporter, putative	0.0068	0.0609	0.8656
Brugia malayi	Sugar transporter family protein	0.0218	0.2255	1
Trypanosoma brucei	lysyl-tRNA synthetase, putative	0.0049	0.0401	0.5705
Brugia malayi	probable proline-trna synthetase - fission yeast, putative	0.0012	0.0003	0.0011
Toxoplasma gondii	facilitative glucose transporter GT1	0.0218	0.2255	0.3408
Trichomonas vaginalis	sugar transporter, putative	0.0031	0.0204	0.0894
Brugia malayi	hypothetical protein	0.0031	0.0204	0.0904
Loa Loa (eye worm)	hypothetical protein	0.0021	0.01	0.0443
Entamoeba histolytica	protein kinase, putative	0.0067	0.0599	1
Brugia malayi	beta-lactamase family protein	0.0035	0.0254	0.1125
Mycobacterium leprae	conserved hypothetical protein	0.0035	0.0254	0.4317
Brugia malayi	beta-lactamase	0.0035	0.0254	0.1125
Plasmodium vivax	calcium-dependent protein kinase 3, putative	0.0067	0.06	0.0597
Echinococcus granulosus	solute carrier family 22	0.0031	0.0204	0.0418
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0204	0.0904
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0035	0.0254	0.1115
Trichomonas vaginalis	conserved hypothetical protein	0.0031	0.0204	0.0894
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0039	0.0173
Loa Loa (eye worm)	hypothetical protein	0.0065	0.0584	0.2591
Plasmodium falciparum	calcium-dependent protein kinase 3	0.0067	0.06	0.0597
Plasmodium vivax	calcium-dependent protein kinase 1, putative	0.0067	0.06	0.0597
Leishmania major	protein kinase, putative	0.0067	0.0599	0.8523
Trichomonas vaginalis	sugar transporter, putative	0.0031	0.0204	0.0894
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0204	0.0904
Trichomonas vaginalis	conserved hypothetical protein	0.0031	0.0204	0.0894
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0254	0.1125
Echinococcus granulosus	solute carrier family 2 facilitated glucose	0.0218	0.2255	0.4677
Trichomonas vaginalis	sugar transporter, putative	0.0031	0.0204	0.0894
Echinococcus multilocularis	calcium:calmodulin dependent protein kinase type	0.0067	0.0599	0.1239
Schistosoma mansoni	sugar transporter	0.0031	0.0204	0.0894
Brugia malayi	Nuclear hormone receptor family member nhr-1	0.0021	0.01	0.0443
Toxoplasma gondii	calcium-dependent protein kinase CDPK2A	0.0067	0.06	0.0903
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0039	0.0173
Echinococcus granulosus	retinoic acid receptor rxr beta a	0.0021	0.01	0.0202
Trypanosoma brucei	glucose transporter, putative	0.0068	0.0609	0.8656
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0204	0.0904
Mycobacterium tuberculosis	Possible conserved lipoprotein LpqK	0.0035	0.0254	0.1079
Trichomonas vaginalis	sugar transporter, putative	0.0031	0.0204	0.0894
Plasmodium falciparum	calcium-dependent protein kinase 5	0.0067	0.06	0.0597
Trichomonas vaginalis	sugar transporter, putative	0.0031	0.0204	0.0894
Mycobacterium tuberculosis	Lysyl-tRNA synthetase 2 LysX	0.0041	0.0321	0.1366
Loa Loa (eye worm)	hypothetical protein	0.0021	0.01	0.0443
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0204	0.0904
Echinococcus granulosus	neuropeptide s receptor	0.0452	0.482	1
Mycobacterium tuberculosis	Probable dicarboxylic acid transport integral membrane protein KgtP (dicarboxylate transporter)	0.0031	0.0204	0.0865
Echinococcus granulosus	beta LACTamase domain containing family member	0.0035	0.0254	0.0522
Trypanosoma cruzi	hypothetical protein, conserved	0.0035	0.0254	0.361
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0204	0.0904
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0204	0.0904
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0016	0.0039	0.0161
Loa Loa (eye worm)	sugar transporter	0.0031	0.0204	0.0904
Echinococcus granulosus	ecdysone induced protein 78C	0.0021	0.01	0.0202
Schistosoma mansoni	retinoic acid receptor RXR	0.0021	0.01	0.0432
Brugia malayi	Nuclear hormone receptor family member nhr-3	0.0021	0.01	0.0443
Echinococcus granulosus	calcium:calmodulin dependent protein kinase type	0.0067	0.0599	0.1239
Entamoeba histolytica	hypothetical protein	0.0049	0.0401	0.6679
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0021	0.01	0.0443
Onchocerca volvulus		0.0031	0.0204	0.053
Echinococcus multilocularis	ecdysone induced protein 78C	0.0021	0.01	0.0202
Brugia malayi	major facilitator superfamily protein	0.0031	0.0204	0.0904
Trypanosoma cruzi	hexose transporter, putative	0.0031	0.0204	0.29
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0204	0.0904
Mycobacterium ulcerans	fusion protein of transposase for IS2606 and sialic acid-transport integral membrane protein NanT	0.0031	0.0204	0.5084
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-49	0.0021	0.01	0.0443
Brugia malayi	Nuclear hormone receptor family member nhr-14	0.0021	0.01	0.0443
Mycobacterium tuberculosis	Possible penicillin-binding protein	0.0225	0.2331	1
Loa Loa (eye worm)	hypothetical protein	0.0021	0.01	0.0443
Onchocerca volvulus		0.0031	0.0204	0.053
Schistosoma mansoni	glucose transport protein	0.0218	0.2255	1
Trypanosoma brucei	THT1 - hexose transporter, putative	0.0068	0.0609	0.8656
Echinococcus granulosus	nuclear receptor subfamily 1 group D	0.0016	0.0039	0.0076
Schistosoma mansoni	hypothetical protein	0.0218	0.2255	1
Mycobacterium ulcerans	sugar-transport integral membrane protein SugI	0.0031	0.0204	0.5084
Mycobacterium ulcerans	integral membrane transport protein	0.0031	0.0204	0.5084
Trypanosoma cruzi	hypothetical protein, conserved	0.0035	0.0254	0.361
Plasmodium vivax	CDK-related protein kinase 6, putative	0.0926	1	1
Schistosoma mansoni	sugar transporter	0.0031	0.0204	0.0894
Brugia malayi	glycyl-tRNA synthetase	0.0012	0.0003	0.0011
Echinococcus multilocularis	synaptic vesicle 2 protein	0.0031	0.0204	0.0418
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0204	0.0904
Echinococcus multilocularis	solute carrier family 2 facilitated glucose	0.0218	0.2255	0.4677

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

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Bibliographic References

No literature references available for this target.

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Detailed information for compound 763710