TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 349.531 | Formula: C20H31NO2S
H donors: 0 H acceptors: 1 LogP: 4.12 Rotable bonds: 10
Rule of 5 violations (Lipinski): 1
SMILES: CSCCCN1CCC(CC1)(CCc1ccccc1)C(=O)OCC
InChi: 1S/C20H31NO2S/c1-3-23-19(22)20(11-10-18-8-5-4-6-9-18)12-15-21(16-13-20)14-7-17-24-2/h4-6,8-9H,3,7,10-17H2,1-2H3
InChiKey: XLVXUGLSZOFQMY-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Schistosoma mansoni	serine/threonine protein kinase	0.0067	0.06	0.2648
Giardia lamblia	Prolyl-tRNA synthetase	0.0066	0.0585	1
Loa Loa (eye worm)	bifunctional aminoacyl-tRNA synthetase	0.0027	0.0163	0.0389
Trypanosoma cruzi	hexose transporter, putative	0.0031	0.0205	0.2908
Mycobacterium ulcerans	fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE	0.0035	0.0252	0.6281
Schistosoma mansoni	nuclear hormone receptor	0.0042	0.0326	0.1431
Echinococcus multilocularis	FTZ F1 nuclear receptor protein	0.0042	0.0326	0.0673
Mycobacterium ulcerans	lysyl-tRNA synthetase	0.0049	0.0402	1
Trypanosoma cruzi	hexose transporter, putative	0.0068	0.0609	0.8657
Schistosoma mansoni	ecdysone-induced protein 78c (dr-78)	0.0031	0.0205	0.0897
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0042	0.0326	0.0673
Trypanosoma brucei	glucose transporter, putative	0.0068	0.0609	0.8657
Brugia malayi	Nuclear hormone receptor family member nhr-31	0.0042	0.0326	0.0777
Schistosoma mansoni	retinoic acid receptor RXR	0.0042	0.0326	0.1431
Brugia malayi	Nuclear hormone receptor-like 1	0.0031	0.0205	0.049
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0042	0.0326	0.0777
Trypanosoma brucei	glucose transporter, putative	0.0068	0.0609	0.8657
Trypanosoma cruzi	sugar transporter, putative	0.0031	0.0205	0.2908
Trypanosoma brucei	glucose transporter 1E	0.0068	0.0609	0.8657
Plasmodium vivax	lysine--tRNA ligase, putative	0.0049	0.0402	0.0399
Loa Loa (eye worm)	threonyl-tRNA synthetase	0.0012	0.0003	0.0008
Echinococcus granulosus	Sugar transporter ERD6 protein	0.0031	0.0205	0.042
Schistosoma mansoni	sugar transporter	0.0031	0.0205	0.0894
Trichomonas vaginalis	sugar transporter, putative	0.0031	0.0205	0.0894
Loa Loa (eye worm)	steroid hormone receptor	0.0042	0.0326	0.0777
Entamoeba histolytica	prolyl-tRNA synthetase, putative	0.0066	0.0585	0.9752
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0252	0.0602
Trichomonas vaginalis	sugar transporter, putative	0.0031	0.0205	0.0894
Onchocerca volvulus		0.0035	0.0252	0.012
Echinococcus multilocularis	solute carrier family 2 facilitated glucose	0.0218	0.2256	0.4703
Toxoplasma gondii	sugar transporter ST1	0.0031	0.0205	0.0305
Echinococcus granulosus	solute carrier family 22	0.0031	0.0205	0.042
Entamoeba histolytica	protein kinase, putative	0.0067	0.06	1
Schistosoma mansoni	Tr4/Tr2 (homologue)	0.0042	0.0326	0.1431
Brugia malayi	Nuclear hormone receptor family member nhr-1	0.0042	0.0326	0.0777
Plasmodium falciparum	calcium-dependent protein kinase 2	0.0067	0.06	0.0597
Loa Loa (eye worm)	hypothetical protein	0.0042	0.0326	0.0777
Echinococcus granulosus	solute carrier family 22	0.0031	0.0205	0.042
Mycobacterium leprae	conserved hypothetical protein	0.0035	0.0252	0.4281
Brugia malayi	Sugar transporter family protein	0.0218	0.2256	0.5384
Mycobacterium leprae	Possible lysyl-tRNA synthetase 2 LysX	0.0049	0.0402	0.6849
Plasmodium vivax	calcium-dependent protein kinase 4, putative	0.0067	0.06	0.0597
Loa Loa (eye worm)	beta-LACTamase domain containing family member	0.0035	0.0252	0.0602
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0042	0.0326	0.1431
Echinococcus multilocularis	solute carrier family 22	0.0031	0.0205	0.042
Brugia malayi	glycyl-tRNA synthetase	0.0012	0.0003	0.0008
Echinococcus granulosus	glutamyl tRNA synthetase cytoplasmic	0.0066	0.0585	0.1215
Loa Loa (eye worm)	hypothetical protein	0.0067	0.06	0.1432
Loa Loa (eye worm)	calcium/calmodulin-dependent protein kinase ID	0.0067	0.06	0.1432
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0205	0.049
Entamoeba histolytica	protein kinase, putative	0.0067	0.06	1
Trichomonas vaginalis	sugar transporter, putative	0.0031	0.0205	0.0894
Toxoplasma gondii	calcium-dependent protein kinase CDPK3	0.0067	0.06	0.0903
Trypanosoma brucei	glucose transporter, putative	0.0068	0.0609	0.8657
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0205	0.0488
Loa Loa (eye worm)	glycyl-tRNA synthetase	0.0012	0.0003	0.0008
Toxoplasma gondii	ABC1 family protein	0.0035	0.0252	0.0377
Echinococcus granulosus	Nuclear hormone receptor family member nhr 41	0.0042	0.0326	0.0673
Brugia malayi	hypothetical protein	0.0031	0.0205	0.049
Plasmodium vivax	calcium-dependent protein kinase, putative	0.0067	0.06	0.0597
Mycobacterium ulcerans	sugar transporter	0.0031	0.0205	0.5093
Mycobacterium ulcerans	beta-lactamase	0.0035	0.0252	0.6281
Echinococcus multilocularis	synaptic vesicle 2 protein	0.0031	0.0205	0.042
Loa Loa (eye worm)	hypothetical protein	0.0042	0.0326	0.0777
Echinococcus granulosus	solute carrier family 2 facilitated glucose	0.0218	0.2256	0.4703
Brugia malayi	Sugar transporter family protein	0.0031	0.0205	0.0488
Brugia malayi	hypothetical protein	0.0031	0.0205	0.0488
Echinococcus granulosus	FTZ F1 nuclear receptor protein	0.0042	0.0326	0.0673
Loa Loa (eye worm)	hypothetical protein	0.0042	0.0326	0.0777
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0042	0.0326	0.0673
Mycobacterium tuberculosis	Probable esterase LipL	0.0035	0.0252	0.1076
Mycobacterium ulcerans	threonyl-tRNA synthetase	0.0012	0.0003	0.0083
Onchocerca volvulus		0.0035	0.0252	0.012
Trichomonas vaginalis	sugar transporter, putative	0.0031	0.0205	0.0894
Trichomonas vaginalis	sugar transporter, putative	0.0031	0.0205	0.0894
Loa Loa (eye worm)	nuclear hormone receptor-like 1	0.0031	0.0205	0.049
Loa Loa (eye worm)	nuclear Hormone Receptor family member	0.0042	0.0326	0.0777
Trichomonas vaginalis	sugar transporter, putative	0.0031	0.0205	0.0894
Trichomonas vaginalis	D-aminoacylase, putative	0.0035	0.0252	0.1106
Echinococcus granulosus	neuropeptide receptor A26	0.045	0.4793	1
Mycobacterium leprae	Probable lipase LipE	0.0035	0.0252	0.4281
Trichomonas vaginalis	myo-inositol transporter, putative	0.0031	0.0205	0.0894
Leishmania major	hypothetical protein, conserved	0.0035	0.0252	0.3586
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0205	0.0488
Schistosoma mansoni	thyroid hormone receptor	0.0042	0.0326	0.1431
Trypanosoma cruzi	hypothetical protein, conserved	0.0035	0.0252	0.3586
Loa Loa (eye worm)	major facilitator superfamily transporter	0.0031	0.0205	0.0488
Trichomonas vaginalis	sugar transporter, putative	0.0031	0.0205	0.0894
Toxoplasma gondii	cell-cycle-associated protein kinase MAPK, putative	0.0353	0.3726	0.5632
Schistosoma mansoni	lysyl-tRNA synthetase	0.0049	0.0402	0.1769
Plasmodium falciparum	calcium-dependent protein kinase 5	0.0067	0.06	0.0597
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0205	0.0488
Plasmodium vivax	hexose transporter	0.0218	0.2256	0.2253
Brugia malayi	threonyl-tRNA synthetase, cytoplasmic	0.0012	0.0003	0.0008
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-49	0.0042	0.0326	0.0777
Mycobacterium tuberculosis	Conserved protein	0.0035	0.0252	0.1076
Echinococcus multilocularis	ecdysone induced protein 78C	0.0042	0.0326	0.0673
Plasmodium vivax	CDK-related protein kinase 6, putative	0.0927	1	1
Brugia malayi	hypothetical protein	0.0031	0.0205	0.0488
Mycobacterium tuberculosis	Probable lipase LipD	0.0035	0.0252	0.1076
Plasmodium falciparum	mitogen-activated protein kinase 2	0.0353	0.3726	0.3724
Mycobacterium tuberculosis	Probable conserved lipoprotein	0.0035	0.0252	0.1076
Giardia lamblia	Hexose transporter	0.0031	0.0205	0.346
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0042	0.0326	0.0777
Echinococcus granulosus	solute carrier family 2 facilitated glucose	0.0218	0.2256	0.4703
Trichomonas vaginalis	sugar transporter, putative	0.0068	0.0609	0.269
Mycobacterium tuberculosis	Lysyl-tRNA synthetase 1 LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase)	0.0041	0.0322	0.1375
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0205	0.0488
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-41	0.0042	0.0326	0.0777
Echinococcus multilocularis	COUP TF:Svp nuclear hormone receptor	0.0042	0.0326	0.0673
Trichomonas vaginalis	conserved hypothetical protein	0.0031	0.0205	0.0894
Plasmodium vivax	calcium-dependent protein kinase 3, putative	0.0067	0.06	0.0597
Trichomonas vaginalis	sugar transporter, putative	0.0031	0.0205	0.0894
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0205	0.0488
Echinococcus multilocularis	General substrate transporter	0.0188	0.192	0.4003
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0205	0.0488
Echinococcus granulosus	synaptic vesicle 2 protein	0.0031	0.0205	0.042
Trypanosoma cruzi	lysyl-tRNA synthetase, putative	0.0049	0.0402	0.5709
Echinococcus multilocularis	calcium dependent protein kinase	0.0063	0.0555	0.1151
Trichomonas vaginalis	sugar transporter, putative	0.0031	0.0205	0.0894
Echinococcus granulosus	geminin	0.0164	0.1663	0.3466
Trichomonas vaginalis	sugar transporter, putative	0.0068	0.0609	0.269
Trypanosoma cruzi	glucose transporter, putative	0.0031	0.0205	0.2908
Trypanosoma brucei	lysyl-tRNA synthetase, putative	0.0049	0.0402	0.5709
Schistosoma mansoni	hypothetical protein	0.0164	0.1663	0.7369
Trichomonas vaginalis	sugar transporter, putative	0.0031	0.0205	0.0894
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0205	0.0488
Echinococcus multilocularis	solute carrier family 2 facilitated glucose	0.0218	0.2256	0.4703
Trichomonas vaginalis	glucose transporter, putative	0.0031	0.0205	0.0894
Echinococcus granulosus	ecdysone induced protein 78C	0.0042	0.0326	0.0673
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0205	0.0488
Trichomonas vaginalis	sugar transporter, putative	0.0031	0.0205	0.0894
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0031	0.0205	0.0897
Mycobacterium ulcerans	esterase/lipase LipP	0.0035	0.0252	0.6281
Plasmodium vivax	calcium-dependent protein kinase 1, putative	0.0067	0.06	0.0597
Chlamydia trachomatis	lysine--tRNA ligase	0.0049	0.0402	1
Mycobacterium tuberculosis	Probable esterase/lipase LipP	0.0035	0.0252	0.1076
Loa Loa (eye worm)	major facilitator superfamily transporter	0.0031	0.0205	0.0488
Leishmania major	glucose transporter/membrane transporter D2, putative	0.0068	0.0609	0.8657
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-40	0.0042	0.0326	0.0777
Trichomonas vaginalis	sugar transporter, putative	0.0031	0.0205	0.0894
Echinococcus multilocularis	neuropeptide s receptor	0.045	0.4793	1
Trypanosoma brucei	glucose transporter, putative	0.0068	0.0609	0.8657
Trypanosoma cruzi	prolyl-tRNA synthetase, putative	0.0076	0.0704	1
Echinococcus granulosus	calcium:calmodulin dependent protein kinase type	0.0067	0.06	0.1246
Mycobacterium tuberculosis	Lysyl-tRNA synthetase 2 LysX	0.0041	0.0322	0.1375
Echinococcus multilocularis	solute carrier family 22	0.0031	0.0205	0.042
Trichomonas vaginalis	sugar transporter, putative	0.0031	0.0205	0.0894
Trichomonas vaginalis	sugar transporter, putative	0.0031	0.0205	0.0894
Brugia malayi	nuclear hormone receptor	0.0042	0.0326	0.0777
Brugia malayi	Major Facilitator Superfamily protein	0.0031	0.0205	0.0488
Schistosoma mansoni	protein kinase	0.0067	0.06	0.2648
Trichomonas vaginalis	sugar transporter, putative	0.0031	0.0205	0.0894
Leishmania major	prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative	0.0076	0.0704	1
Echinococcus multilocularis	Nuclear hormone receptor family member nhr 41	0.0042	0.0326	0.0673
Echinococcus granulosus	beta LACTamase domain containing family member	0.0035	0.0252	0.052
Brugia malayi	photoreceptor-specific nuclear receptor	0.0042	0.0326	0.0777
Plasmodium falciparum	protein kinase 7	0.0617	0.6613	0.6612
Trichomonas vaginalis	sugar transporter, putative	0.0031	0.0205	0.0894
Echinococcus granulosus	calcium:calmodulin dependent protein kinase type 1	0.0067	0.06	0.1246
Trichomonas vaginalis	sugar transporter, putative	0.0031	0.0205	0.0894
Echinococcus multilocularis	neuropeptide receptor A26	0.045	0.4793	1
Leishmania major	glucose transporter, lmgt3	0.0068	0.0609	0.8657
Leishmania major	myo-inositol/proton symporter (MIT)	0.0031	0.0205	0.2908
Schistosoma mansoni	glucose transport protein	0.0218	0.2256	1
Echinococcus granulosus	calcium:calmodulin dependent protein kinase type	0.0067	0.06	0.1246
Brugia malayi	steroid hormone receptor	0.0042	0.0326	0.0777
Mycobacterium ulcerans	integral membrane transport protein	0.0031	0.0205	0.5093
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0205	0.049
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0042	0.0326	0.0673
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0042	0.0326	0.0777
Plasmodium falciparum	hexose transporter	0.0218	0.2256	0.2253
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0042	0.0326	0.0777
Brugia malayi	ecdysteroid receptor	0.0395	0.419	1
Brugia malayi	lysyl-tRNA synthetase	0.0049	0.0402	0.0959
Echinococcus granulosus	COUP TF:Svp nuclear hormone receptor	0.0042	0.0326	0.0673
Brugia malayi	major facilitator superfamily protein	0.0031	0.0205	0.0488
Loa Loa (eye worm)	hypothetical protein	0.0049	0.0402	0.0959
Schistosoma mansoni	RAR-like nuclear receptor	0.0042	0.0326	0.1431
Mycobacterium ulcerans	prolyl-tRNA synthetase	0.0023	0.0122	0.3036
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0205	0.049
Onchocerca volvulus	Steroid hormone receptor family member cnr14 homolog	0.0042	0.0326	0.0303
Schistosoma mansoni	sugar transporter	0.0031	0.0205	0.0894
Echinococcus granulosus	solute carrier family 22	0.0031	0.0205	0.042
Echinococcus multilocularis	solute carrier family 2, facilitated glucose	0.0218	0.2256	0.4703
Brugia malayi	Steroid receptor seven-up type 2	0.0042	0.0326	0.0777
Trypanosoma brucei	myo-inositol/proton symporter (MIT)	0.0031	0.0205	0.2908
Echinococcus granulosus	solute carrier family 22	0.0031	0.0205	0.042
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0252	0.0602
Leishmania major	threonyl-tRNA synthetase, putative	0.0012	0.0003	0.0047
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0252	0.0602
Echinococcus granulosus	FTZ F1 alpha	0.0042	0.0326	0.0673
Toxoplasma gondii	facilitative glucose transporter GT1	0.0218	0.2256	0.3408
Schistosoma mansoni	protein kinase	0.0067	0.06	0.2648
Brugia malayi	Calcium/calmodulin-dependent protein kinase type II alpha chain	0.0067	0.06	0.1432
Mycobacterium tuberculosis	Probable conserved integral membrane transport protein	0.0031	0.0205	0.087
Trypanosoma brucei	glycyl-tRNA synthetase, putative	0.0012	0.0003	0.0047
Trypanosoma brucei	calcium/calmodulin-dependent protein kinase, putative	0.0067	0.06	0.8524
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0205	0.0488
Loa Loa (eye worm)	hypothetical protein	0.0042	0.0326	0.0777
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0042	0.0326	0.0673
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0252	0.0602
Brugia malayi	Nuclear hormone receptor family member nhr-41	0.0042	0.0326	0.0777
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-14	0.0042	0.0326	0.0777
Trichomonas vaginalis	D-aminoacylase, putative	0.0035	0.0252	0.1106
Trichomonas vaginalis	conserved hypothetical protein	0.0031	0.0205	0.0894
Schistosoma mansoni	nuclear receptor 2DBD-gamma	0.0042	0.0326	0.1431
Echinococcus multilocularis	calcium:calmodulin dependent protein kinase type	0.0067	0.06	0.1246
Toxoplasma gondii	sugar transporter ST3	0.0031	0.0205	0.0305
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0035	0.0252	0.1106
Trichomonas vaginalis	conserved hypothetical protein	0.0068	0.0609	0.269
Trichomonas vaginalis	sugar transporter, putative	0.0031	0.0205	0.0894
Plasmodium falciparum	major facilitator superfamily domain-containing protein, putative	0.0031	0.0205	0.0201
Schistosoma mansoni	nuclear hormone receptor nor-1/nor-2	0.0042	0.0326	0.1431
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0035	0.0252	0.1106
Schistosoma mansoni	coup transcription factor	0.0042	0.0326	0.1431
Plasmodium vivax	proline--tRNA ligase, putative	0.0076	0.0704	0.0701
Echinococcus multilocularis	solute carrier family 22	0.0031	0.0205	0.042
Trichomonas vaginalis	lysyl-tRNA synthetase, putative	0.0049	0.0402	0.1769
Brugia malayi	Major Facilitator Superfamily protein	0.0031	0.0205	0.0488
Brugia malayi	beta-lactamase	0.0035	0.0252	0.0602
Plasmodium falciparum	calcium-dependent protein kinase 3	0.0067	0.06	0.0597
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0252	0.0602
Brugia malayi	probable proline-trna synthetase - fission yeast, putative	0.0012	0.0003	0.0008
Trichomonas vaginalis	sugar transport protein, putative	0.0031	0.0205	0.0894
Trichomonas vaginalis	sugar transporter, putative	0.0031	0.0205	0.0894
Loa Loa (eye worm)	hypothetical protein	0.0053	0.0451	0.1076
Toxoplasma gondii	lysine-tRNA ligase	0.0049	0.0402	0.0603
Echinococcus multilocularis	calcium:calmodulin dependent protein kinase type	0.0067	0.06	0.1246
Brugia malayi	nuclear receptor NHR-88	0.0042	0.0326	0.0777
Trypanosoma brucei	threonyl-tRNA synthetase, putative	0.0012	0.0003	0.0047
Wolbachia endosymbiont of Brugia malayi	major facilitator superfamily permease	0.0031	0.0205	1
Plasmodium falciparum	calcium-dependent protein kinase 1	0.0067	0.06	0.0597
Giardia lamblia	Sugar-proton symporter	0.0031	0.0205	0.346
Brugia malayi	Bifunctional aminoacyl-tRNA synthetase	0.0066	0.0585	0.1396
Mycobacterium ulcerans	lysyl-tRNA synthetase	0.0049	0.0402	1
Trypanosoma cruzi	prolyl-tRNA synthetase, putative	0.0076	0.0704	1
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0205	0.0488
Loa Loa (eye worm)	sugar transporter	0.0218	0.2256	0.5384
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0042	0.0326	0.0777
Trypanosoma brucei	THT1 - hexose transporter, putative	0.0068	0.0609	0.8657
Brugia malayi	hypothetical protein	0.0031	0.0205	0.0488
Loa Loa (eye worm)	hypothetical protein	0.0066	0.0585	0.1396
Trypanosoma brucei	glucose transporter, putative	0.0068	0.0609	0.8657
Brugia malayi	Nuclear hormone receptor family member nhr-40	0.0042	0.0326	0.0777
Trichomonas vaginalis	sugar transporter, putative	0.0031	0.0205	0.0894
Echinococcus multilocularis	thyroid hormone receptor alpha	0.0042	0.0326	0.0673
Echinococcus granulosus	hepatocyte nuclear factor 4 alpha	0.0042	0.0326	0.0673
Trypanosoma brucei	hypothetical protein, conserved	0.0035	0.0252	0.3586
Onchocerca volvulus	Protein ultraspiracle homolog	0.0042	0.0326	0.0303
Plasmodium falciparum	lysine--tRNA ligase	0.0049	0.0402	0.0399
Toxoplasma gondii	calcium-dependent protein kinase CDPK2A	0.0067	0.06	0.0903
Mycobacterium ulcerans	hypothetical protein	0.0035	0.0252	0.6281
Brugia malayi	Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative	0.0035	0.0252	0.0602
Schistosoma mansoni	lysyl-tRNA synthetase	0.0049	0.0402	0.1769
Toxoplasma gondii	transporter, major facilitator family protein	0.0031	0.0205	0.0305
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-1	0.0042	0.0326	0.0777
Mycobacterium tuberculosis	Probable lipase LipE	0.0035	0.0252	0.1076
Trypanosoma brucei	glucose transporter, putative	0.0068	0.0609	0.8657
Mycobacterium tuberculosis	Possible conserved lipoprotein LpqK	0.0035	0.0252	0.1076
Brugia malayi	Nuclear hormone receptor-like 1	0.0042	0.0326	0.0777
Trichomonas vaginalis	glucose transporter, putative	0.0068	0.0609	0.269
Onchocerca volvulus		0.0035	0.0252	0.012
Schistosoma mansoni	sugar transporter	0.0031	0.0205	0.0894
Schistosoma mansoni	photoreceptor-specific nuclear receptor related	0.0042	0.0326	0.1431
Mycobacterium tuberculosis	Probable dicarboxylic acid transport integral membrane protein KgtP (dicarboxylate transporter)	0.0031	0.0205	0.087
Mycobacterium ulcerans	sugar-transport integral membrane protein SugI	0.0031	0.0205	0.5093
Loa Loa (eye worm)	sugar transporter	0.0031	0.0205	0.0488
Mycobacterium ulcerans	lipase LipD	0.0035	0.0252	0.6281
Echinococcus multilocularis	geminin	0.0164	0.1663	0.3466
Brugia malayi	hypothetical protein	0.0031	0.0205	0.049
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0205	0.0488
Echinococcus granulosus	lysyl tRNA synthetase	0.0049	0.0402	0.0832
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0205	0.049
Trichomonas vaginalis	sugar transporter, putative	0.0031	0.0205	0.0894
Echinococcus multilocularis	solute carrier family 22	0.0031	0.0205	0.042
Leishmania major	lysyl-tRNA synthetase, putative	0.0049	0.0402	0.5709
Schistosoma mansoni	glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs)	0.0066	0.0585	0.2583
Trypanosoma brucei	THT1 - hexose transporter, putative	0.0068	0.0609	0.8657
Leishmania major	glucose transporter, lmgt1	0.0068	0.0609	0.8657
Schistosoma mansoni	thyroid hormone receptor	0.0042	0.0326	0.1431
Trichomonas vaginalis	sugar transporter, putative	0.0031	0.0205	0.0894
Trichomonas vaginalis	penicillin-binding protein, putative	0.0035	0.0252	0.1106
Mycobacterium leprae	Probable prolyl tRNA synthetase ProS	0.0066	0.0585	1
Toxoplasma gondii	prolyl-tRNA synthetase (ProRS)	0.0076	0.0704	0.106
Brugia malayi	Nuclear hormone receptor family member nhr-3	0.0042	0.0326	0.0777
Schistosoma mansoni	FTZ-F1 nuclear receptor-like protein	0.0042	0.0326	0.1431
Trichomonas vaginalis	D-aminoacylase, putative	0.0035	0.0252	0.1106
Plasmodium vivax	sugar transporter, putative	0.0031	0.0205	0.0201
Chlamydia trachomatis	proline--tRNA ligase	0.0023	0.0122	0.2978
Trypanosoma cruzi	hexose transporter, putative	0.0068	0.0609	0.8657
Trichomonas vaginalis	sugar transporter, putative	0.0031	0.0205	0.0894
Echinococcus granulosus	nuclear receptor subfamily 1 group D	0.0031	0.0205	0.0422
Echinococcus granulosus	solute carrier family 2 facilitated glucose	0.0218	0.2256	0.4703
Trypanosoma cruzi	threonyl-tRNA synthetase, putative	0.0012	0.0003	0.0047
Schistosoma mansoni	protein kinase	0.0067	0.06	0.2648
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0205	0.0488
Loa Loa (eye worm)	CAMK/CAMK2 protein kinase	0.0067	0.06	0.1432
Trichomonas vaginalis	sugar transporter, putative	0.0031	0.0205	0.0894
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0205	0.0488
Trichomonas vaginalis	sugar transporter, putative	0.0031	0.0205	0.0894
Mycobacterium leprae	Probable lysyl-tRNA synthase LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase)	0.0041	0.0322	0.5469
Schistosoma mansoni	glucose transport protein	0.0218	0.2256	1
Trichomonas vaginalis	sugar transporter, putative	0.0031	0.0205	0.0894
Trichomonas vaginalis	lysyl-tRNA synthetase, putative	0.0043	0.0336	0.1477
Echinococcus multilocularis	beta LACTamase domain containing family member	0.0035	0.0252	0.052
Brugia malayi	Nuclear hormone receptor family member nhr-14	0.0042	0.0326	0.0777
Echinococcus multilocularis	glutamyl tRNA synthetase cytoplasmic	0.0066	0.0585	0.1215
Echinococcus granulosus	calcium:calmodulin dependent protein kinase type	0.0067	0.06	0.1246
Echinococcus multilocularis	calcium:calmodulin dependent protein kinase type	0.0067	0.06	0.1246
Trichomonas vaginalis	conserved hypothetical protein	0.0068	0.0609	0.269
Trichomonas vaginalis	conserved hypothetical protein	0.0218	0.2256	1
Echinococcus multilocularis	Sugar transporter ERD6 protein	0.0031	0.0205	0.042
Brugia malayi	Cam kinase protein 1	0.0067	0.06	0.1432
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0205	0.0488
Echinococcus multilocularis	calcium:calmodulin dependent protein kinase type	0.0067	0.06	0.1246
Plasmodium falciparum	calcium-dependent protein kinase 4	0.0067	0.06	0.0597
Echinococcus granulosus	neuropeptide s receptor	0.045	0.4793	1
Leishmania major	prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative	0.0076	0.0704	1
Trichomonas vaginalis	conserved hypothetical protein	0.0031	0.0205	0.0894
Leishmania major	protein kinase, putative	0.0067	0.06	0.8524
Trichomonas vaginalis	sugar transporter, putative	0.0031	0.0205	0.0894
Mycobacterium tuberculosis	Conserved protein	0.0035	0.0252	0.1076
Trypanosoma cruzi	hypothetical protein, conserved	0.0035	0.0252	0.3586
Schistosoma mansoni	steroid hormone receptor ad4bp	0.0042	0.0326	0.1431
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0205	0.049
Loa Loa (eye worm)	hypothetical protein	0.0066	0.0585	0.1396
Echinococcus granulosus	calcium dependent protein kinase	0.0063	0.0555	0.1151
Schistosoma mansoni	glucose transporter	0.0031	0.0205	0.0894
Echinococcus multilocularis	nuclear receptor subfamily 1 group D	0.0031	0.0205	0.0422
Trichomonas vaginalis	sugar transporter, putative	0.0031	0.0205	0.0894
Brugia malayi	Nuclear hormone receptor family member nhr-49	0.0042	0.0326	0.0777
Schistosoma mansoni	nuclear transcription factor X-box binding 1 (nfx1)	0.0031	0.0205	0.0894
Plasmodium vivax	hypothetical protein, conserved	0.0035	0.0252	0.0249
Trichomonas vaginalis	sugar transporter, putative	0.0031	0.0205	0.0894
Echinococcus granulosus	solute carrier family 2 facilitated glucose	0.0218	0.2256	0.4703
Brugia malayi	nuclear receptor RXR	0.0031	0.0205	0.049
Toxoplasma gondii	sugar transporter ST2	0.0031	0.0205	0.0305
Echinococcus multilocularis	solute carrier family 2 facilitated glucose	0.0218	0.2256	0.4703
Leishmania major	hypothetical protein, conserved	0.0031	0.0205	0.2908
Brugia malayi	Nuclear hormone receptor-like 1	0.0031	0.0205	0.049
Echinococcus multilocularis	FTZ F1 alpha	0.0042	0.0326	0.0673
Trypanosoma brucei	glucose transporter, putative	0.0068	0.0609	0.8657
Trichomonas vaginalis	prolyl-tRNA synthetase, putative	0.0066	0.0585	0.2583
Trichomonas vaginalis	sugar transporter, putative	0.0031	0.0205	0.0894
Trichomonas vaginalis	glucose transporter, putative	0.0068	0.0609	0.269
Toxoplasma gondii	calcium-dependent protein kinase CDPK2B	0.0067	0.06	0.0903
Trypanosoma brucei	sugar transporter, putative	0.0031	0.0205	0.2908
Brugia malayi	beta-lactamase family protein	0.0035	0.0252	0.0602
Mycobacterium ulcerans	glycyl-tRNA synthetase	0.0012	0.0003	0.0083
Loa Loa (eye worm)	hypothetical protein	0.0042	0.0326	0.0777
Schistosoma mansoni	hypothetical protein	0.0218	0.2256	1
Echinococcus multilocularis	lysyl tRNA synthetase	0.0049	0.0402	0.0832
Treponema pallidum	prolyl-tRNA synthetase	0.0023	0.0122	1
Entamoeba histolytica	hypothetical protein	0.0049	0.0402	0.6679
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0252	0.0602
Trypanosoma cruzi	hexose transporter, putative	0.0068	0.0609	0.8657
Loa Loa (eye worm)	hypothetical protein	0.0042	0.0326	0.0777
Trichomonas vaginalis	CAMK family protein kinase	0.0067	0.06	0.2648
Brugia malayi	major facilitator superfamily protein	0.0031	0.0205	0.0488
Echinococcus granulosus	retinoic acid receptor rxr beta a	0.0042	0.0326	0.0673
Trypanosoma cruzi	hexose transporter, putative	0.0037	0.0274	0.3889
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0003	0.0008
Onchocerca volvulus		0.0042	0.0326	0.0303
Loa Loa (eye worm)	beta-lactamase	0.0035	0.0252	0.0602
Mycobacterium tuberculosis	Probable hydrolase	0.0035	0.0252	0.1076
Brugia malayi	bifunctional aminoacyl-tRNA synthetase	0.0066	0.0585	0.1396
Trypanosoma cruzi	hexose transporter	0.0068	0.0609	0.8657
Leishmania major	glucose transporter, lmgt2	0.0068	0.0609	0.8657
Mycobacterium tuberculosis	Possible penicillin-binding protein	0.0224	0.2318	1
Trichomonas vaginalis	sugar transporter, putative	0.0031	0.0205	0.0894
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-31	0.0042	0.0326	0.0777
Trichomonas vaginalis	sugar transporter, putative	0.0031	0.0205	0.0894
Loa Loa (eye worm)	hypothetical protein	0.0042	0.0326	0.0777
Onchocerca volvulus	Bile acid receptor homolog	0.0395	0.419	1
Toxoplasma gondii	protein kinase, putative	0.0617	0.6613	1
Trypanosoma brucei	glucose transporter, putative	0.0068	0.0609	0.8657
Trypanosoma brucei	glucose transporter 2A	0.0068	0.0609	0.8657
Trichomonas vaginalis	conserved hypothetical protein	0.0031	0.0205	0.0894
Trypanosoma brucei	bifunctional aminoacyl-tRNA synthetase, putative	0.0076	0.0704	1
Trichomonas vaginalis	sugar transporter, putative	0.0031	0.0205	0.0894
Trichomonas vaginalis	penicillin-binding protein, putative	0.0035	0.0252	0.1106
Trichomonas vaginalis	sugar transporter, putative	0.0031	0.0205	0.0894
Trichomonas vaginalis	sugar transporter, putative	0.0068	0.0609	0.269
Brugia malayi	Sugar transporter family protein	0.0031	0.0205	0.0488
Plasmodium falciparum	proline--tRNA ligase	0.0076	0.0704	0.0701
Loa Loa (eye worm)	hypothetical protein	0.0395	0.419	1
Schistosoma mansoni	glucose transport protein	0.0218	0.2256	1
Brugia malayi	Major Facilitator Superfamily protein	0.0031	0.0205	0.0488
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0042	0.0326	0.0777
Schistosoma mansoni	hypothetical protein	0.0164	0.1663	0.7369
Mycobacterium tuberculosis	Conserved protein	0.0035	0.0252	0.1076
Trichomonas vaginalis	conserved hypothetical protein	0.0031	0.0205	0.0894
Mycobacterium ulcerans	fusion protein of transposase for IS2606 and sialic acid-transport integral membrane protein NanT	0.0031	0.0205	0.5093
Echinococcus multilocularis	hepatocyte nuclear factor 4 alpha	0.0042	0.0326	0.0673
Giardia lamblia	Lysyl-tRNA synthetase	0.0049	0.0402	0.6849
Echinococcus granulosus	General substrate transporter	0.0188	0.192	0.4003
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0205	0.0488
Trichomonas vaginalis	esterase, putative	0.0035	0.0252	0.1106
Schistosoma mansoni	sugar transporter	0.0031	0.0205	0.0894
Trypanosoma cruzi	threonyl-tRNA synthetase, putative	0.0012	0.0003	0.0047
Brugia malayi	beta-lactamase family protein	0.0035	0.0252	0.0602
Trichomonas vaginalis	sugar transporter, putative	0.0031	0.0205	0.0894
Trypanosoma brucei	THT1 - hexose transporter, putative	0.0068	0.0609	0.8657
Schistosoma mansoni	glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs)	0.0066	0.0585	0.2583
Plasmodium vivax	mitogen-activated protein kinase 2, putative	0.0353	0.3726	0.3724

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

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Bibliographic References

No literature references available for this target.

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Detailed information for compound 763714