TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 304.359 | Formula: C17H21FN2O2
H donors: 1 H acceptors: 2 LogP: 2.6 Rotable bonds: 4
Rule of 5 violations (Lipinski): 1
SMILES: OCC1CCCCN1Cc1nc(oc1C)c1ccc(cc1)F
InChi: 1S/C17H21FN2O2/c1-12-16(10-20-9-3-2-4-15(20)11-21)19-17(22-12)13-5-7-14(18)8-6-13/h5-8,15,21H,2-4,9-11H2,1H3
InChiKey: KNKNICLHXBDPNG-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Schistosoma mansoni	glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs)	0.0065	0.0595	0.2583
Trichomonas vaginalis	glucose transporter, putative	0.0067	0.0619	0.274
Toxoplasma gondii	threonyl-tRNA synthetase family protein	0.0012	0.0016	0.0023
Entamoeba histolytica	protein kinase, putative	0.0069	0.0642	0.4377
Trichomonas vaginalis	sugar transporter, putative	0.003	0.0216	0.0956
Brugia malayi	lysyl-tRNA synthetase	0.0048	0.0412	0.1769
Schistosoma mansoni	protein kinase	0.0069	0.0642	0.2792
Leishmania major	glucose transporter, lmgt1	0.0067	0.0619	0.428
Trichomonas vaginalis	conserved hypothetical protein	0.0067	0.0619	0.274
Toxoplasma gondii	exonuclease III APE	0.0019	0.0091	0.0137
Trichomonas vaginalis	sugar transporter, putative	0.003	0.0216	0.0956
Plasmodium vivax	hypothetical protein, conserved	0.0038	0.0293	0.0278
Echinococcus granulosus	calcium:calmodulin dependent protein kinase type	0.0069	0.0642	0.1217
Loa Loa (eye worm)	hypothetical protein	0.003	0.0216	0.0894
Trichomonas vaginalis	sugar transporter, putative	0.003	0.0216	0.0956
Leishmania major	glucose transporter, lmgt3	0.0067	0.0619	0.428
Trichomonas vaginalis	sugar transporter, putative	0.003	0.0216	0.0956
Trypanosoma cruzi	cdc2-related kinase 1	0.0143	0.1446	1
Trypanosoma cruzi	lysyl-tRNA synthetase, putative	0.0048	0.0412	0.2851
Toxoplasma gondii	sugar transporter ST2	0.003	0.0216	0.0326
Echinococcus multilocularis	calcium dependent protein kinase	0.0062	0.0565	0.1067
Trichomonas vaginalis	sugar transporter, putative	0.003	0.0216	0.0956
Schistosoma mansoni	sugar transporter	0.003	0.0216	0.0894
Echinococcus multilocularis	cyclin dependent kinase 5	0.0143	0.1446	0.278
Loa Loa (eye worm)	hypothetical protein	0.003	0.0216	0.0894
Leishmania major	myo-inositol/proton symporter (MIT)	0.003	0.0216	0.1494
Echinococcus granulosus	calcium:calmodulin dependent protein kinase type	0.0069	0.0642	0.1217
Trichomonas vaginalis	penicillin-binding protein, putative	0.0038	0.0293	0.1297
Mycobacterium tuberculosis	Probable threonyl-tRNA synthetase ThrS (threonine-tRNA synthetase)(ThrRS) (threonine-tRNA ligase)	0.0012	0.0016	0.0062
Trypanosoma cruzi	hypothetical protein, conserved	0.0038	0.0293	0.2025
Echinococcus multilocularis	beta LACTamase domain containing family member	0.0038	0.0293	0.0539
Mycobacterium tuberculosis	Possible conserved lipoprotein LpqK	0.0038	0.0293	0.1168
Mycobacterium leprae	Probable prolyl tRNA synthetase ProS	0.0065	0.0595	1
Schistosoma mansoni	glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs)	0.0065	0.0595	0.2583
Trichomonas vaginalis	D-aminoacylase, putative	0.0038	0.0293	0.1297
Plasmodium falciparum	calcium-dependent protein kinase 1	0.0069	0.0642	0.0627
Trichomonas vaginalis	sugar transporter, putative	0.003	0.0216	0.0956
Schistosoma mansoni	sugar transporter	0.003	0.0216	0.0894
Echinococcus granulosus	solute carrier family 2 facilitated glucose	0.0217	0.2258	0.4359
Schistosoma mansoni	protein kinase	0.0069	0.0642	0.2792
Plasmodium vivax	calcium-dependent protein kinase, putative	0.0069	0.0642	0.0627
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.005	0.0428	0.184
Trypanosoma cruzi	hexose transporter, putative	0.0037	0.0285	0.1969
Leishmania major	threonyl-tRNA synthetase, putative	0.0012	0.0016	0.0108
Brugia malayi	Sugar transporter family protein	0.003	0.0216	0.0894
Trichomonas vaginalis	sugar transporter, putative	0.003	0.0216	0.0956
Mycobacterium tuberculosis	Probable lipase LipD	0.0038	0.0293	0.1168
Mycobacterium ulcerans	hypothetical protein	0.0038	0.0293	0.7103
Entamoeba histolytica	cell division protein kinase 2, putative	0.0143	0.1446	1
Trypanosoma brucei	glucose transporter, putative	0.0067	0.0619	0.428
Toxoplasma gondii	sugar transporter ST3	0.003	0.0216	0.0326
Trichomonas vaginalis	conserved hypothetical protein	0.003	0.0216	0.0956
Loa Loa (eye worm)	beta-LACTamase domain containing family member	0.0038	0.0293	0.1236
Leishmania major	prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative	0.0076	0.0713	0.493
Trypanosoma brucei	cdc2-related kinase 3	0.0143	0.1446	1
Trypanosoma brucei	THT1 - hexose transporter, putative	0.0067	0.0619	0.428
Trichomonas vaginalis	sugar transporter, putative	0.003	0.0216	0.0956
Trichomonas vaginalis	sugar transporter, putative	0.003	0.0216	0.0956
Trypanosoma brucei	glucose transporter, putative	0.0067	0.0619	0.428
Echinococcus multilocularis	solute carrier family 22	0.003	0.0216	0.039
Trypanosoma brucei	glucose transporter 2A	0.0067	0.0619	0.428
Trichomonas vaginalis	sugar transporter, putative	0.003	0.0216	0.0956
Loa Loa (eye worm)	exodeoxyribonuclease III family protein	0.0019	0.0091	0.0336
Schistosoma mansoni	hypothetical protein	0.0176	0.1806	0.7981
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0038	0.0293	0.1236
Echinococcus multilocularis	synaptic vesicle 2 protein	0.003	0.0216	0.039
Mycobacterium ulcerans	sugar transporter	0.003	0.0216	0.5239
Trichomonas vaginalis	conserved hypothetical protein	0.003	0.0216	0.0956
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0293	0.1236
Trypanosoma cruzi	glucose transporter, putative	0.003	0.0216	0.1494
Echinococcus granulosus	cyclin dependent kinase 5	0.0143	0.1446	0.278
Brugia malayi	Major Facilitator Superfamily protein	0.003	0.0216	0.0894
Mycobacterium leprae	Possible lysyl-tRNA synthetase 2 LysX	0.0048	0.0412	0.6932
Loa Loa (eye worm)	hypothetical protein	0.003	0.0216	0.0894
Trichomonas vaginalis	CMGC family protein kinase	0.0143	0.1446	0.6403
Loa Loa (eye worm)	hypothetical protein	0.003	0.0216	0.0894
Echinococcus multilocularis	Sugar transporter ERD6 protein	0.003	0.0216	0.039
Trypanosoma brucei	lysyl-tRNA synthetase, putative	0.0048	0.0412	0.2851
Trypanosoma cruzi	hexose transporter, putative	0.0067	0.0619	0.428
Loa Loa (eye worm)	hypothetical protein	0.003	0.0216	0.0894
Mycobacterium tuberculosis	Conserved protein	0.0038	0.0293	0.1168
Echinococcus multilocularis	calcium:calmodulin dependent protein kinase type	0.0069	0.0642	0.1217
Trypanosoma cruzi	hexose transporter	0.0067	0.0619	0.428
Loa Loa (eye worm)	hypothetical protein	0.0065	0.0595	0.2583
Trypanosoma cruzi	sugar transporter, putative	0.003	0.0216	0.1494
Entamoeba histolytica	hypothetical protein	0.0048	0.0412	0.2774
Trichomonas vaginalis	sugar transporter, putative	0.003	0.0216	0.0956
Echinococcus multilocularis	lysyl tRNA synthetase	0.0048	0.0412	0.0771
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0293	0.1236
Echinococcus granulosus	cyclin dependent kinase	0.0143	0.1446	0.278
Trichomonas vaginalis	sugar transporter, putative	0.003	0.0216	0.0956
Trypanosoma brucei	glucose transporter, putative	0.0067	0.0619	0.428
Echinococcus granulosus	cyclin dependent kinase 1	0.0143	0.1446	0.278
Mycobacterium tuberculosis	Lysyl-tRNA synthetase 1 LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase)	0.0041	0.0332	0.1325
Brugia malayi	Sugar transporter family protein	0.0217	0.2258	1
Entamoeba histolytica	exodeoxyribonuclease III, putative	0.0019	0.0091	0.0528
Loa Loa (eye worm)	CMGC/CDK/CDC2 protein kinase	0.0143	0.1446	0.6378
Trypanosoma brucei	THT1 - hexose transporter, putative	0.0067	0.0619	0.428
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.005	0.0428	0.0802
Trichomonas vaginalis	CMGC family protein kinase	0.0143	0.1446	0.6403
Trichomonas vaginalis	sugar transporter, putative	0.003	0.0216	0.0956
Mycobacterium ulcerans	sugar-transport integral membrane protein SugI	0.003	0.0216	0.5239
Trichomonas vaginalis	sugar transporter, putative	0.003	0.0216	0.0956
Echinococcus granulosus	solute carrier family 2 facilitated glucose	0.0217	0.2258	0.4359
Trichomonas vaginalis	sugar transporter, putative	0.003	0.0216	0.0956
Echinococcus multilocularis	solute carrier family 2, facilitated glucose	0.0217	0.2258	0.4359
Trichomonas vaginalis	sugar transporter, putative	0.003	0.0216	0.0956
Brugia malayi	hypothetical protein	0.003	0.0216	0.0894
Brugia malayi	Cytochrome P450 family protein	0.0013	0.0022	0.003
Trichomonas vaginalis	sugar transporter, putative	0.003	0.0216	0.0956
Chlamydia trachomatis	lysine--tRNA ligase	0.0048	0.0412	1
Brugia malayi	Cytochrome P450 family protein	0.0013	0.0022	0.003
Echinococcus multilocularis	solute carrier family 22	0.003	0.0216	0.039
Trichomonas vaginalis	conserved hypothetical protein	0.0067	0.0619	0.274
Echinococcus granulosus	calcium:calmodulin dependent protein kinase type	0.0069	0.0642	0.1217
Brugia malayi	major facilitator superfamily protein	0.003	0.0216	0.0894
Trichomonas vaginalis	lysyl-tRNA synthetase, putative	0.0048	0.0412	0.1826
Toxoplasma gondii	transporter, major facilitator family protein	0.003	0.0216	0.0326
Brugia malayi	hypothetical protein	0.003	0.0216	0.0894
Plasmodium falciparum	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	0.0019	0.0091	0.0076
Plasmodium falciparum	calcium-dependent protein kinase 3	0.0069	0.0642	0.0627
Giardia lamblia	Endonuclease/Exonuclease/phosphatase	0.0019	0.0091	0.0528
Trypanosoma cruzi	cdc2-related kinase 3	0.0143	0.1446	1
Echinococcus granulosus	neuropeptide s receptor	0.0482	0.516	1
Echinococcus granulosus	calcium:calmodulin dependent protein kinase type 1	0.0069	0.0642	0.1217
Mycobacterium ulcerans	cytochrome P450 185A4 Cyp185A4	0.0013	0.0022	0.054
Trichomonas vaginalis	CAMK family protein kinase	0.0069	0.0642	0.2841
Entamoeba histolytica	protein kinase, putative	0.0069	0.0642	0.4377
Trichomonas vaginalis	conserved hypothetical protein	0.003	0.0216	0.0956
Echinococcus granulosus	General substrate transporter	0.0186	0.1924	0.371
Leishmania major	cell division protein kinase 2,cdc2-related kinase	0.0143	0.1446	1
Schistosoma mansoni	protein kinase	0.0069	0.0642	0.2792
Plasmodium falciparum	calcium-dependent protein kinase 2	0.0069	0.0642	0.0627
Trypanosoma brucei	glucose transporter, putative	0.0067	0.0619	0.428
Schistosoma mansoni	lysyl-tRNA synthetase	0.0048	0.0412	0.1769
Brugia malayi	Sugar transporter family protein	0.003	0.0216	0.0894
Trypanosoma brucei	apurinic/apyrimidinic endonuclease, putative	0.0019	0.0091	0.0629
Echinococcus granulosus	glutamyl tRNA synthetase cytoplasmic	0.0065	0.0595	0.1126
Brugia malayi	beta-lactamase family protein	0.0038	0.0293	0.1236
Echinococcus granulosus	geminin	0.0176	0.1806	0.3479
Echinococcus granulosus	solute carrier family 22	0.003	0.0216	0.039
Wolbachia endosymbiont of Brugia malayi	major facilitator superfamily permease	0.003	0.0216	1
Giardia lamblia	Hexose transporter	0.003	0.0216	0.1401
Toxoplasma gondii	calcium-dependent protein kinase CDPK3	0.0069	0.0642	0.0969
Toxoplasma gondii	glycyl-tRNA synthetase	0.0012	0.0016	0.0023
Toxoplasma gondii	calcium-dependent protein kinase CDPK2B	0.0069	0.0642	0.0969
Echinococcus granulosus	solute carrier family 2 facilitated glucose	0.0217	0.2258	0.4359
Brugia malayi	exodeoxyribonuclease III family protein	0.0019	0.0091	0.0336
Trichomonas vaginalis	sugar transporter, putative	0.003	0.0216	0.0956
Plasmodium falciparum	proline--tRNA ligase	0.0076	0.0713	0.0698
Echinococcus multilocularis	solute carrier family 2 facilitated glucose	0.0217	0.2258	0.4359
Loa Loa (eye worm)	calcium/calmodulin-dependent protein kinase ID	0.0069	0.0642	0.2792
Plasmodium falciparum	protein kinase 5	0.0143	0.1446	0.1433
Mycobacterium ulcerans	prolyl-tRNA synthetase	0.0023	0.0134	0.3243
Loa Loa (eye worm)	hypothetical protein	0.003	0.0216	0.0894
Loa Loa (eye worm)	hypothetical protein	0.003	0.0216	0.0894
Mycobacterium tuberculosis	Probable lipase LipE	0.0038	0.0293	0.1168
Schistosoma mansoni	hypothetical protein	0.0176	0.1806	0.7981
Wolbachia endosymbiont of Brugia malayi	exonuclease III	0.0019	0.0091	0.3765
Trypanosoma cruzi	hexose transporter, putative	0.0067	0.0619	0.428
Mycobacterium leprae	Probable lysyl-tRNA synthase LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase)	0.0041	0.0332	0.5587
Leishmania major	hypothetical protein, conserved	0.003	0.0216	0.1494
Trichomonas vaginalis	sugar transporter, putative	0.003	0.0216	0.0956
Loa Loa (eye worm)	hypothetical protein	0.003	0.0216	0.0894
Loa Loa (eye worm)	beta-lactamase	0.0038	0.0293	0.1236
Loa Loa (eye worm)	CMGC/CDK/CDC2 protein kinase	0.0143	0.1446	0.6378
Trichomonas vaginalis	sugar transporter, putative	0.003	0.0216	0.0956
Plasmodium vivax	hexose transporter	0.0217	0.2258	0.2246
Toxoplasma gondii	cell-cycle-associated protein kinase MAPK, putative	0.0353	0.3754	0.5664
Loa Loa (eye worm)	CMGC/CDK/CDK5 protein kinase	0.0143	0.1446	0.6378
Trypanosoma cruzi	cdc2-related kinase 1	0.0143	0.1446	1
Schistosoma mansoni	nuclear transcription factor X-box binding 1 (nfx1)	0.003	0.0216	0.0894
Treponema pallidum	prolyl-tRNA synthetase	0.0023	0.0134	1
Giardia lamblia	Sugar-proton symporter	0.003	0.0216	0.1401
Trypanosoma cruzi	hexose transporter, putative	0.003	0.0216	0.1494
Trichomonas vaginalis	sugar transporter, putative	0.003	0.0216	0.0956
Schistosoma mansoni	serine/threonine protein kinase	0.0143	0.1446	0.6378
Toxoplasma gondii	cell-cycle-associated protein kinase CDK, putative	0.0143	0.1446	0.2182
Giardia lamblia	Kinase, CMGC CDK	0.0143	0.1446	1
Toxoplasma gondii	protein kinase, putative	0.0616	0.6628	1
Plasmodium vivax	mitogen-activated protein kinase 2, putative	0.0353	0.3754	0.3744
Mycobacterium tuberculosis	Probable esterase LipL	0.0038	0.0293	0.1168
Trichomonas vaginalis	sugar transporter, putative	0.003	0.0216	0.0956
Mycobacterium ulcerans	esterase/lipase LipP	0.0038	0.0293	0.7103
Trichomonas vaginalis	sugar transporter, putative	0.003	0.0216	0.0956
Schistosoma mansoni	hypothetical protein	0.0217	0.2258	1
Leishmania major	prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative	0.0076	0.0713	0.493
Leishmania major	cell division related protein kinase 2,cdc2-related kinase	0.0143	0.1446	1
Trypanosoma brucei	glucose transporter, putative	0.0067	0.0619	0.428
Loa Loa (eye worm)	hypothetical protein	0.003	0.0216	0.0894
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0038	0.0293	0.1236
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.005	0.0428	0.184
Echinococcus granulosus	calcium dependent protein kinase	0.0062	0.0565	0.1067
Mycobacterium leprae	conserved hypothetical protein	0.0038	0.0293	0.4924
Trypanosoma cruzi	prolyl-tRNA synthetase, putative	0.0076	0.0713	0.493
Trichomonas vaginalis	conserved hypothetical protein	0.003	0.0216	0.0956
Loa Loa (eye worm)	hypothetical protein	0.0136	0.1368	0.6032
Onchocerca volvulus		0.0038	0.0293	1
Echinococcus granulosus	beta LACTamase domain containing family member	0.0038	0.0293	0.0539
Leishmania major	glucose transporter/membrane transporter D2, putative	0.0067	0.0619	0.428
Trypanosoma cruzi	threonyl-tRNA synthetase, putative	0.0012	0.0016	0.0108
Brugia malayi	bifunctional aminoacyl-tRNA synthetase	0.0065	0.0595	0.2583
Schistosoma mansoni	glucose transport protein	0.0217	0.2258	1
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.005	0.0428	0.0802
Brugia malayi	Major Facilitator Superfamily protein	0.003	0.0216	0.0894
Trypanosoma brucei	glycyl-tRNA synthetase, putative	0.0012	0.0016	0.0108
Plasmodium falciparum	calcium-dependent protein kinase 4	0.0069	0.0642	0.0627
Trypanosoma brucei	cdc2-related kinase 1	0.0143	0.1446	1
Trypanosoma cruzi	cytochrome P450, putative	0.0013	0.0022	0.0154
Plasmodium vivax	calcium-dependent protein kinase 4, putative	0.0069	0.0642	0.0627
Echinococcus multilocularis	calcium:calmodulin dependent protein kinase type	0.0069	0.0642	0.1217
Leishmania major	protein kinase, putative	0.0069	0.0642	0.4437
Trichomonas vaginalis	glucose transporter, putative	0.003	0.0216	0.0956
Toxoplasma gondii	lysine-tRNA ligase	0.0048	0.0412	0.0622
Brugia malayi	beta-lactamase	0.0038	0.0293	0.1236
Schistosoma mansoni	serine/threonine protein kinase	0.0069	0.0642	0.2792
Trichomonas vaginalis	sugar transporter, putative	0.0067	0.0619	0.274
Echinococcus multilocularis	solute carrier family 2 facilitated glucose	0.0217	0.2258	0.4359
Loa Loa (eye worm)	hypothetical protein	0.003	0.0216	0.0894
Echinococcus multilocularis	solute carrier family 22	0.003	0.0216	0.039
Mycobacterium ulcerans	lysyl-tRNA synthetase	0.0048	0.0412	1
Mycobacterium tuberculosis	Lysyl-tRNA synthetase 2 LysX	0.0041	0.0332	0.1325
Brugia malayi	Cam kinase protein 1	0.0069	0.0642	0.2792
Echinococcus multilocularis	calcium:calmodulin dependent protein kinase type	0.0069	0.0642	0.1217
Trichomonas vaginalis	D-aminoacylase, putative	0.0038	0.0293	0.1297
Trichomonas vaginalis	ap endonuclease, putative	0.0019	0.0091	0.0403
Mycobacterium ulcerans	fusion protein of transposase for IS2606 and sialic acid-transport integral membrane protein NanT	0.003	0.0216	0.5239
Plasmodium falciparum	hexose transporter	0.0217	0.2258	0.2246
Trypanosoma cruzi	hypothetical protein, conserved	0.0038	0.0293	0.2025
Toxoplasma gondii	ABC1 family protein	0.0038	0.0293	0.0442
Trichomonas vaginalis	sugar transporter, putative	0.003	0.0216	0.0956
Trypanosoma brucei	glucose transporter 1E	0.0067	0.0619	0.428
Onchocerca volvulus		0.0038	0.0293	1
Trichomonas vaginalis	sugar transporter, putative	0.003	0.0216	0.0956
Leishmania major	apurinic/apyrimidinic endonuclease-redox protein	0.0019	0.0091	0.0629
Schistosoma mansoni	ap endonuclease	0.0019	0.0091	0.0336
Trichomonas vaginalis	prolyl-tRNA synthetase, putative	0.0065	0.0595	0.2634
Plasmodium vivax	protein kinase Crk2	0.0143	0.1446	0.1433
Trichomonas vaginalis	sugar transporter, putative	0.003	0.0216	0.0956
Schistosoma mansoni	serine/threonine protein kinase	0.0143	0.1446	0.6378
Giardia lamblia	Lysyl-tRNA synthetase	0.0048	0.0412	0.2774
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0293	0.1236
Plasmodium falciparum	major facilitator superfamily domain-containing protein, putative	0.003	0.0216	0.0201
Trypanosoma cruzi	cdc2-related kinase 3	0.0143	0.1446	1
Giardia lamblia	Prolyl-tRNA synthetase	0.0065	0.0595	0.4049
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0293	0.1236
Loa Loa (eye worm)	cytochrome P450 family protein	0.0013	0.0022	0.003
Echinococcus multilocularis	cyclin dependent kinase 1	0.0143	0.1446	0.278
Trichomonas vaginalis	sugar transporter, putative	0.0067	0.0619	0.274
Leishmania major	lysyl-tRNA synthetase, putative	0.0048	0.0412	0.2851
Trichomonas vaginalis	esterase, putative	0.0038	0.0293	0.1297
Trypanosoma brucei	hypothetical protein, conserved	0.0038	0.0293	0.2025
Trichomonas vaginalis	sugar transporter, putative	0.003	0.0216	0.0956
Trypanosoma brucei	threonyl-tRNA synthetase, putative	0.0012	0.0016	0.0108
Trypanosoma brucei	glucose transporter, putative	0.0067	0.0619	0.428
Plasmodium vivax	calcium-dependent protein kinase 3, putative	0.0069	0.0642	0.0627
Echinococcus granulosus	5'partial\|cyclin dependent kinase 1	0.0143	0.1446	0.278
Echinococcus granulosus	solute carrier family 2 facilitated glucose	0.0217	0.2258	0.4359
Mycobacterium tuberculosis	Conserved protein	0.0038	0.0293	0.1168
Mycobacterium ulcerans	threonyl-tRNA synthetase	0.0012	0.0016	0.0377
Loa Loa (eye worm)	sugar transporter	0.0217	0.2258	1
Loa Loa (eye worm)	hypothetical protein	0.003	0.0216	0.0894
Mycobacterium tuberculosis	Conserved protein	0.0038	0.0293	0.1168
Trichomonas vaginalis	sugar transporter, putative	0.003	0.0216	0.0956
Plasmodium vivax	CDK-related protein kinase 6, putative	0.0923	1	1
Plasmodium vivax	lysine--tRNA ligase, putative	0.0048	0.0412	0.0397
Leishmania major	hypothetical protein, conserved	0.0038	0.0293	0.2025
Mycobacterium ulcerans	fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE	0.0038	0.0293	0.7103
Schistosoma mansoni	glucose transport protein	0.0217	0.2258	1
Mycobacterium leprae	Probable threonyl-tRNA synthetase ThrS (threonine-tRNA synthetase) (ThrRS) (Threonine-tRNA ligase)	0.0012	0.0016	0.0262
Plasmodium falciparum	calcium-dependent protein kinase 5	0.0069	0.0642	0.0627
Trichomonas vaginalis	glucose transporter, putative	0.0067	0.0619	0.274
Mycobacterium tuberculosis	Possible penicillin-binding protein	0.024	0.2508	1
Loa Loa (eye worm)	CYP4Cod1	0.0013	0.0022	0.003
Trichomonas vaginalis	sugar transporter, putative	0.003	0.0216	0.0956
Trypanosoma brucei	myo-inositol/proton symporter (MIT)	0.003	0.0216	0.1494
Mycobacterium ulcerans	beta-lactamase	0.0038	0.0293	0.7103
Loa Loa (eye worm)	major facilitator superfamily transporter	0.003	0.0216	0.0894
Echinococcus multilocularis	solute carrier family 22	0.003	0.0216	0.039
Plasmodium vivax	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	0.0019	0.0091	0.0076
Brugia malayi	Major Facilitator Superfamily protein	0.003	0.0216	0.0894
Echinococcus multilocularis	neuropeptide s receptor	0.0482	0.516	1
Mycobacterium tuberculosis	Probable esterase/lipase LipP	0.0038	0.0293	0.1168
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease, putative	0.0019	0.0091	0.0629
Echinococcus multilocularis	glutamyl tRNA synthetase cytoplasmic	0.0065	0.0595	0.1126
Mycobacterium ulcerans	exodeoxyribonuclease III protein XthA	0.0019	0.0091	0.2208
Plasmodium vivax	sugar transporter, putative	0.003	0.0216	0.0201
Echinococcus multilocularis	DNA (apurinic or apyrimidinic site) lyase	0.0019	0.0091	0.0147
Brugia malayi	beta-lactamase family protein	0.0038	0.0293	0.1236
Mycobacterium tuberculosis	Probable conserved lipoprotein	0.0038	0.0293	0.1168
Mycobacterium tuberculosis	Probable hydrolase	0.0038	0.0293	0.1168
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.005	0.0428	0.0802
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.005	0.0428	0.184
Trichomonas vaginalis	sugar transporter, putative	0.003	0.0216	0.0956
Schistosoma mansoni	sugar transporter	0.003	0.0216	0.0894
Trichomonas vaginalis	conserved hypothetical protein	0.0217	0.2258	1
Echinococcus granulosus	solute carrier family 22	0.003	0.0216	0.039
Loa Loa (eye worm)	hypothetical protein	0.0048	0.0412	0.1769
Trypanosoma brucei	sugar transporter, putative	0.003	0.0216	0.1494
Trichomonas vaginalis	conserved hypothetical protein	0.003	0.0216	0.0956
Trypanosoma brucei	calcium/calmodulin-dependent protein kinase, putative	0.0069	0.0642	0.4437
Trichomonas vaginalis	sugar transporter, putative	0.003	0.0216	0.0956
Echinococcus granulosus	lysyl tRNA synthetase	0.0048	0.0412	0.0771
Trypanosoma brucei	cytochrome P450, putative	0.0013	0.0022	0.0154
Loa Loa (eye worm)	major facilitator superfamily transporter	0.003	0.0216	0.0894
Brugia malayi	cell division control protein 2 homolog	0.0143	0.1446	0.6378
Loa Loa (eye worm)	CAMK/CAMK2 protein kinase	0.0069	0.0642	0.2792
Chlamydia trachomatis	proline--tRNA ligase	0.0023	0.0134	0.2978
Brugia malayi	hypothetical protein	0.003	0.0216	0.0894
Loa Loa (eye worm)	hypothetical protein	0.0069	0.0642	0.2792
Onchocerca volvulus		0.0038	0.0293	1
Plasmodium vivax	calcium-dependent protein kinase 1, putative	0.0069	0.0642	0.0627
Entamoeba histolytica	cell division protein kinase 2, putative	0.0143	0.1446	1
Trichomonas vaginalis	CMGC family protein kinase	0.0143	0.1446	0.6403
Echinococcus granulosus	neuropeptide receptor A26	0.0482	0.516	1
Trichomonas vaginalis	sugar transport protein, putative	0.003	0.0216	0.0956
Plasmodium falciparum	lysine--tRNA ligase	0.0048	0.0412	0.0397
Trypanosoma brucei	bifunctional aminoacyl-tRNA synthetase, putative	0.0076	0.0713	0.493
Trypanosoma cruzi	cytochrome P450, putative	0.0013	0.0022	0.0154
Loa Loa (eye worm)	hypothetical protein	0.003	0.0216	0.0894
Trypanosoma cruzi	hexose transporter, putative	0.0067	0.0619	0.428
Toxoplasma gondii	prolyl-tRNA synthetase (ProRS)	0.0076	0.0713	0.1076
Brugia malayi	Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative	0.0038	0.0293	0.1236
Toxoplasma gondii	sugar transporter ST1	0.003	0.0216	0.0326
Loa Loa (eye worm)	sugar transporter	0.003	0.0216	0.0894
Loa Loa (eye worm)	hypothetical protein	0.003	0.0216	0.0894
Entamoeba histolytica	prolyl-tRNA synthetase, putative	0.0065	0.0595	0.4049
Trichomonas vaginalis	sugar transporter, putative	0.003	0.0216	0.0956
Schistosoma mansoni	glucose transport protein	0.0217	0.2258	1
Mycobacterium tuberculosis	Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI)	0.0019	0.0091	0.0363
Brugia malayi	major facilitator superfamily protein	0.003	0.0216	0.0894
Giardia lamblia	Kinase, CMGC CDK	0.0143	0.1446	1
Trypanosoma brucei	THT1 - hexose transporter, putative	0.0067	0.0619	0.428
Schistosoma mansoni	glucose transporter	0.003	0.0216	0.0894
Echinococcus multilocularis	cyclin dependent kinase 1	0.0143	0.1446	0.278
Echinococcus multilocularis	cyclin dependent kinase	0.0143	0.1446	0.278
Trichomonas vaginalis	sugar transporter, putative	0.003	0.0216	0.0956
Trypanosoma brucei	glucose transporter, putative	0.0067	0.0619	0.428
Trichomonas vaginalis	sugar transporter, putative	0.0067	0.0619	0.274
Schistosoma mansoni	ap endonuclease	0.0019	0.0091	0.0336
Mycobacterium ulcerans	integral membrane transport protein	0.003	0.0216	0.5239
Echinococcus multilocularis	geminin	0.0176	0.1806	0.3479
Loa Loa (eye worm)	hypothetical protein	0.003	0.0216	0.0894
Mycobacterium ulcerans	glycyl-tRNA synthetase	0.0012	0.0016	0.0377
Echinococcus multilocularis	calcium:calmodulin dependent protein kinase type	0.0069	0.0642	0.1217
Treponema pallidum	exodeoxyribonuclease (exoA)	0.0019	0.0091	0.6388
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.005	0.0428	0.184
Loa Loa (eye worm)	cytochrome P450 family protein	0.0013	0.0022	0.003
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0293	0.1236
Mycobacterium ulcerans	lysyl-tRNA synthetase	0.0048	0.0412	1
Mycobacterium leprae	Probable lipase LipE	0.0038	0.0293	0.4924
Leishmania major	cytochrome p450-like protein	0.0013	0.0022	0.0154
Trichomonas vaginalis	sugar transporter, putative	0.003	0.0216	0.0956
Echinococcus granulosus	DNA apurinic or apyrimidinic site lyase	0.0019	0.0091	0.0147
Echinococcus multilocularis	solute carrier family 2 facilitated glucose	0.0217	0.2258	0.4359
Mycobacterium ulcerans	lipase LipD	0.0038	0.0293	0.7103
Trichomonas vaginalis	ap endonuclease, putative	0.0019	0.0091	0.0403
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease	0.0019	0.0091	0.0629
Brugia malayi	Bifunctional aminoacyl-tRNA synthetase	0.0065	0.0595	0.2583
Trypanosoma cruzi	threonyl-tRNA synthetase, putative	0.0012	0.0016	0.0108
Trichomonas vaginalis	D-aminoacylase, putative	0.0038	0.0293	0.1297
Trypanosoma brucei	glucose transporter, putative	0.0067	0.0619	0.428
Schistosoma mansoni	sugar transporter	0.003	0.0216	0.0894
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.005	0.0428	0.184
Leishmania major	glucose transporter, lmgt2	0.0067	0.0619	0.428
Trichomonas vaginalis	lysyl-tRNA synthetase, putative	0.0042	0.0347	0.1536
Plasmodium falciparum	mitogen-activated protein kinase 2	0.0353	0.3754	0.3744
Toxoplasma gondii	facilitative glucose transporter GT1	0.0217	0.2258	0.3407
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.005	0.0428	0.0802
Loa Loa (eye worm)	hypothetical protein	0.0053	0.0461	0.1987
Trichomonas vaginalis	myo-inositol transporter, putative	0.003	0.0216	0.0956
Trichomonas vaginalis	penicillin-binding protein, putative	0.0038	0.0293	0.1297
Mycobacterium tuberculosis	Probable conserved integral membrane transport protein	0.003	0.0216	0.0861
Brugia malayi	Calcium/calmodulin-dependent protein kinase type II alpha chain	0.0069	0.0642	0.2792
Plasmodium vivax	proline--tRNA ligase, putative	0.0076	0.0713	0.0698
Echinococcus granulosus	synaptic vesicle 2 protein	0.003	0.0216	0.039
Echinococcus multilocularis	General substrate transporter	0.0186	0.1924	0.371
Echinococcus multilocularis	neuropeptide receptor A26	0.0482	0.516	1
Toxoplasma gondii	calcium-dependent protein kinase CDPK2A	0.0069	0.0642	0.0969
Echinococcus granulosus	solute carrier family 22	0.003	0.0216	0.039
Plasmodium falciparum	protein kinase 7	0.0616	0.6628	0.6623
Echinococcus granulosus	solute carrier family 22	0.003	0.0216	0.039
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0293	0.1236
Loa Loa (eye worm)	hypothetical protein	0.0065	0.0595	0.2583
Loa Loa (eye worm)	hypothetical protein	0.003	0.0216	0.0894
Brugia malayi	Protein kinase domain containing protein	0.0143	0.1446	0.6378
Echinococcus granulosus	Sugar transporter ERD6 protein	0.003	0.0216	0.039
Trypanosoma cruzi	prolyl-tRNA synthetase, putative	0.0076	0.0713	0.493
Schistosoma mansoni	lysyl-tRNA synthetase	0.0048	0.0412	0.1769
Mycobacterium tuberculosis	Probable dicarboxylic acid transport integral membrane protein KgtP (dicarboxylate transporter)	0.003	0.0216	0.0861
Trichomonas vaginalis	threonyl-tRNA synthetase, putative	0.0012	0.0016	0.0069
Loa Loa (eye worm)	bifunctional aminoacyl-tRNA synthetase	0.0027	0.0175	0.0709
Trichomonas vaginalis	sugar transporter, putative	0.003	0.0216	0.0956

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

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Bibliographic References

No literature references available for this target.

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Detailed information for compound 763800