TDR Targets

Basic information

Technical information

TDR Targets ID: 774041
Name: 10-ethyl-3,3,6,6-tetramethyl-9-(3-prop-2-ynox yphenyl)-4,5,7,9-tetrahydro-2H-acridine-1,8-d ione
MW: 431.567 | Formula: C28H33NO3
H donors: 0 H acceptors: 2 LogP: 4.57 Rotable bonds: 4
Rule of 5 violations (Lipinski): 1
SMILES: C#CCOc1cccc(c1)C1C2=C(CC(CC2=O)(C)C)N(C2=C1C(=O)CC(C2)(C)C)CC
InChi: 1S/C28H33NO3/c1-7-12-32-19-11-9-10-18(13-19)24-25-20(14-27(3,4)16-22(25)30)29(8-2)21-15-28(5,6)17-23(31)26(21)24/h1,9-11,13,24H,8,12,14-17H2,2-6H3
InChiKey: PKDBUMFGQCFBJW-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

10-ethyl-3,3,6,6-tetramethyl-9-(3-propargyloxyphenyl)-4,5,7,9-tetrahydro-2H-acridine-1,8-quinone
EU-0080193

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus multilocularis	survival motor neuron protein 1	0.0234	0.2638	0.2638
Onchocerca volvulus		0.0039	0.0331	0.2173
Trypanosoma cruzi	hypothetical protein, conserved	0.0039	0.0331	0.4962
Loa Loa (eye worm)	hypothetical protein	0.0756	0.8822	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0062	0.0605	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0016	0.0061	0.1069
Loa Loa (eye worm)	histone methyltransferase	0.0019	0.0088	0.003
Toxoplasma gondii	histone lysine methyltransferase SET1	0.0114	0.1215	0.1318
Brugia malayi	Cathepsin L-like precursor	0.0016	0.0061	0.0011
Trypanosoma cruzi	major cysteine proteinase, putative	0.0049	0.0447	0.7098
Toxoplasma gondii	LsmAD domain-containing protein	0.0025	0.0163	0.0116
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0039	0.0331	0.0331
Loa Loa (eye worm)	hypothetical protein	0.0055	0.0524	0.0529
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0062	0.0605	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0062	0.0605	1
Echinococcus multilocularis	mixed lineage leukemia protein mll	0.0015	0.0044	0.0044
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.005	0.0456	0.1543
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0016	0.0061	0.1069
Schistosoma mansoni	hypothetical protein	0.0067	0.0666	0.0666
Trypanosoma cruzi	PAB1-binding protein , putative	0.0025	0.0163	0.1873
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.005	0.0456	0.0456
Trypanosoma cruzi	hypothetical protein, conserved	0.0039	0.0331	0.4962
Entamoeba histolytica	cysteine proteinase, putative	0.0016	0.0061	0.5
Leishmania major	hypothetical protein, conserved	0.0039	0.0331	0.4962
Brugia malayi	Cathepsin L-like precursor	0.0016	0.0061	0.0011
Loa Loa (eye worm)	hypothetical protein	0.0039	0.0331	0.0308
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0016	0.0061	0.1069
Brugia malayi	Cathepsin L-like precursor	0.0016	0.0061	0.0011
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0099	0.1036	0.3789
Loa Loa (eye worm)	hypothetical protein	0.0055	0.0524	0.0529
Plasmodium vivax	ataxin-2 like protein, putative	0.0025	0.0163	0.3774
Schistosoma mansoni	hypothetical protein	0.0031	0.0237	0.0237
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.005	0.0456	0.0451
Brugia malayi	hypothetical protein	0.0025	0.0163	0.0406
Echinococcus granulosus	cathepsin l cysteine peptidase	0.0016	0.0061	0.0061
Echinococcus multilocularis	beta LACTamase domain containing family member	0.0039	0.0331	0.0331
Brugia malayi	F/Y-rich N-terminus family protein	0.0018	0.0085	0.0103
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0062	0.0605	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0016	0.0061	0.1069
Echinococcus granulosus	potassium voltage gated channel subfamily KQT	0.0055	0.0524	0.0524
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0062	0.0605	1
Brugia malayi	beta-lactamase family protein	0.0039	0.0331	0.1057
Mycobacterium tuberculosis	Possible penicillin-binding protein	0.025	0.2828	1
Plasmodium falciparum	ataxin-2 like protein, putative	0.0025	0.0163	1
Entamoeba histolytica	cysteine proteinase, putative	0.0016	0.0061	0.5
Echinococcus granulosus	beta LACTamase domain containing family member	0.0039	0.0331	0.0331
Brugia malayi	hypothetical protein	0.0121	0.1303	0.4825
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0016	0.0061	0.1069
Mycobacterium leprae	Probable lipase LipE	0.0039	0.0331	0.5
Onchocerca volvulus	Huntingtin homolog	0.0121	0.1303	1
Trichomonas vaginalis	D-aminoacylase, putative	0.0039	0.0331	1
Schistosoma mansoni	hypothetical protein	0.0335	0.3837	0.3837
Echinococcus granulosus	potassium channel KvQLT family member kqt 1	0.0123	0.1327	0.1327
Schistosoma mansoni	hypothetical protein	0.0031	0.0237	0.0237
Trypanosoma brucei	hypothetical protein, conserved	0.0039	0.0331	0.3802
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0016	0.0061	0.1069
Echinococcus multilocularis	histone lysine N methyltransferase MLL3	0.0015	0.0044	0.0044
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.005	0.0456	0.0456
Loa Loa (eye worm)	hypothetical protein	0.0039	0.0331	0.0308
Loa Loa (eye worm)	hypothetical protein	0.0039	0.0331	0.0308
Schistosoma mansoni	hypothetical protein	0.0335	0.3837	0.3837
Trypanosoma cruzi	cruzipain precursor, putative	0.0062	0.0605	1
Plasmodium vivax	hypothetical protein, conserved	0.0039	0.0331	1
Echinococcus granulosus	histone lysine N methyltransferase MLL3	0.0019	0.0088	0.0088
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0016	0.0061	0.1069
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0016	0.0061	0.1069
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.005	0.0456	0.0456
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0016	0.0061	0.1069
Entamoeba histolytica	cysteine protease, putative	0.0016	0.0061	0.5
Brugia malayi	Cathepsin L-like precursor	0.0016	0.0061	0.0011
Leishmania major	cathepsin L-like protease	0.0062	0.0605	1
Brugia malayi	Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative	0.0039	0.0331	0.1057
Echinococcus granulosus	cathepsin L cysteine proteinase	0.0016	0.0061	0.0061
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0015	0.0044	0.0044
Echinococcus granulosus	GPCR family 2	0.0031	0.0237	0.0237
Echinococcus granulosus	geminin	0.0335	0.3837	0.3837
Loa Loa (eye worm)	hypothetical protein	0.0039	0.0331	0.0308
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0237	0.0201
Brugia malayi	Papain family cysteine protease containing protein	0.0016	0.0061	0.0011
Schistosoma mansoni	cathepsin F (C01 family)	0.0016	0.0061	0.0061
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0031	0.0237	0.0237
Echinococcus multilocularis	histone lysine N methyltransferase MLL3	0.0019	0.0088	0.0088
Loa Loa (eye worm)	hypothetical protein	0.0067	0.0666	0.0691
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0039	0.0331	0.0331
Schistosoma mansoni	hypothetical protein	0.0048	0.0433	0.0433
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0062	0.0605	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0016	0.0061	0.1069
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.005	0.0456	0.0456
Schistosoma mansoni	cathepsin F (C01 family)	0.0016	0.0061	0.0061
Loa Loa (eye worm)	hypothetical protein	0.0121	0.1303	0.1418
Mycobacterium leprae	conserved hypothetical protein	0.0039	0.0331	0.5
Onchocerca volvulus		0.0048	0.0433	0.2992
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0016	0.0061	0.1069
Echinococcus multilocularis	geminin	0.0335	0.3837	0.3837
Schistosoma mansoni	hypothetical protein	0.0031	0.0237	0.0237
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0016	0.0061	0.1069
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0016	0.0061	0.1069
Echinococcus granulosus	cpg binding protein	0.0064	0.062	0.062
Loa Loa (eye worm)	hypothetical protein	0.0039	0.0331	0.0308
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0062	0.0605	1
Echinococcus granulosus	cathepsin l1	0.0016	0.0061	0.0061
Brugia malayi	Cathepsin L-like precursor	0.0016	0.0061	0.0011
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0016	0.0061	0.1069
Brugia malayi	Voltage-gated potassium channel, KCNQ (Kv7-like) alpha-subunit. C. elegans kqt-1 ortholog	0.0123	0.1327	0.4918
Trichomonas vaginalis	penicillin-binding protein, putative	0.0039	0.0331	1
Echinococcus granulosus	histone lysine N methyltransferase MLL3	0.0015	0.0044	0.0044
Brugia malayi	beta-lactamase family protein	0.0039	0.0331	0.1057
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0016	0.0061	0.1069
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0031	0.0237	0.0237
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0016	0.0061	0.1069
Trichomonas vaginalis	penicillin-binding protein, putative	0.0039	0.0331	1
Echinococcus multilocularis	cathepsin L cysteine protease	0.0016	0.0061	0.0061
Mycobacterium tuberculosis	Probable epoxide hydrolase EphA (epoxide hydratase) (arene-oxide hydratase)	0.0163	0.1797	0.5871
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.005	0.0456	0.0456
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0062	0.0605	1
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0031	0.0237	0.0237
Plasmodium falciparum	ataxin-2 like protein, putative	0.0025	0.0163	1
Schistosoma mansoni	microtubule-associated protein tau	0.0674	0.7842	0.7842
Loa Loa (eye worm)	voltage-gated potassium channel	0.0121	0.1302	0.1417
Brugia malayi	hypothetical protein	0.0234	0.2638	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0016	0.0061	0.1069
Loa Loa (eye worm)	inward rectifying k channel family protein 1	0.0756	0.8822	1
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0099	0.1036	0.3789
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0062	0.0605	1
Loa Loa (eye worm)	hypothetical protein	0.0039	0.0331	0.0308
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0016	0.0061	0.1069
Loa Loa (eye worm)	beta-lactamase	0.0039	0.0331	0.0308
Loa Loa (eye worm)	CXXC zinc finger family protein	0.006	0.0579	0.0591
Trypanosoma cruzi	cysteine peptidase, putative	0.0062	0.0605	1
Echinococcus multilocularis	cathepsin L cysteine protease	0.0016	0.0061	0.0061
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0016	0.0061	0.1069
Onchocerca volvulus	Huntingtin homolog	0.0121	0.1303	1
Schistosoma mansoni	survival motor neuron protein	0.0048	0.0433	0.0433
Toxoplasma gondii	hypothetical protein	0.0756	0.8822	1
Onchocerca volvulus		0.0039	0.0331	0.2173
Loa Loa (eye worm)	hypothetical protein	0.0099	0.1036	0.1113
Echinococcus multilocularis	potassium voltage gated channel subfamily KQT	0.0123	0.1327	0.1327
Schistosoma mansoni	cpg binding protein	0.0064	0.062	0.062
Echinococcus multilocularis	microtubule associated protein 2	0.0674	0.7842	0.7842
Schistosoma mansoni	hypothetical protein	0.0856	1	1
Leishmania major	cathepsin L-like protease	0.0062	0.0605	1
Loa Loa (eye worm)	hypothetical protein	0.0756	0.8822	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0016	0.0061	0.1069
Echinococcus multilocularis	cysteine protease	0.0016	0.0061	0.0061
Brugia malayi	beta-lactamase	0.0039	0.0331	0.1057
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0031	0.0237	0.0694
Loa Loa (eye worm)	beta-LACTamase domain containing family member	0.0039	0.0331	0.0308
Trichomonas vaginalis	D-aminoacylase, putative	0.0039	0.0331	1
Echinococcus granulosus	microtubule associated protein 2	0.0674	0.7842	0.7842
Loa Loa (eye worm)	hypothetical protein	0.0234	0.2638	0.2942
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0016	0.0061	0.1069
Echinococcus multilocularis	potassium voltage gated channel subfamily KQT	0.0055	0.0524	0.0524
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.005	0.0456	0.0456
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0031	0.0237	0.0237
Echinococcus multilocularis	cysteine protease	0.0016	0.0061	0.0061
Schistosoma mansoni	hypothetical protein	0.0031	0.0237	0.0237
Trichomonas vaginalis	D-aminoacylase, putative	0.0039	0.0331	1
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0031	0.0237	0.0201
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0099	0.1036	0.1113
Toxoplasma gondii	ABC1 family protein	0.0039	0.0331	0.0308
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0016	0.0061	0.1069
Onchocerca volvulus		0.0039	0.0331	0.2173
Loa Loa (eye worm)	hypothetical protein	0.0121	0.1303	0.1418
Brugia malayi	Iron-sulfur cluster assembly accessory protein	0.0048	0.0433	0.1451
Schistosoma mansoni	cpg binding protein	0.0064	0.062	0.062
Trichomonas vaginalis	esterase, putative	0.0039	0.0331	1
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.005	0.0456	0.0456
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0016	0.0061	0.1069
Echinococcus granulosus	mixed lineage leukemia protein mll	0.0015	0.0044	0.0044
Schistosoma mansoni	cpg binding protein	0.006	0.0579	0.0579
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0062	0.0605	1
Schistosoma mansoni	voltage-gated potassium channel KCNQ	0.0123	0.1327	0.1327
Loa Loa (eye worm)	potassium voltage-gated channel subfamily Q member 5	0.0055	0.0524	0.0529
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0062	0.0605	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0016	0.0061	0.1069
Echinococcus granulosus	survival motor neuron protein 1	0.0234	0.2638	0.2638
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0016	0.0061	0.0061
Trypanosoma cruzi	cysteine peptidase, putative	0.0062	0.0605	1
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0016	0.0061	0.0061
Echinococcus multilocularis	dnaJ subfamily B	0.0856	1	1
Brugia malayi	latrophilin 2 splice variant baaae	0.0067	0.0666	0.2356
Trypanosoma cruzi	cysteine peptidase, clan CA, family C1, cathepsin L-like, putative	0.0057	0.0541	0.8824
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0127	0.1377	0.1377
Mycobacterium ulcerans	epoxide hydrolase EphA	0.0163	0.1797	1
Trypanosoma cruzi	PAB1-binding protein , putative	0.0025	0.0163	0.1873
Echinococcus multilocularis	cpg binding protein	0.0064	0.062	0.062
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0163	0.0116
Brugia malayi	Latrophilin receptor protein 2	0.0031	0.0237	0.0694
Loa Loa (eye worm)	hypothetical protein	0.0756	0.8822	1
Brugia malayi	Cathepsin L-like precursor	0.0016	0.0061	0.0011
Leishmania major	hypothetical protein, conserved	0.0025	0.0163	0.1873
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0016	0.0061	0.1069
Echinococcus multilocularis	GPCR, family 2	0.0031	0.0237	0.0237
Brugia malayi	CXXC zinc finger family protein	0.006	0.0579	0.2018
Leishmania major	cathepsin L-like protease	0.0062	0.0605	1
Onchocerca volvulus		0.006	0.0579	0.417
Trypanosoma cruzi	cysteine peptidase, putative	0.0062	0.0605	1

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

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Bibliographic References

No literature references available for this target.

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Detailed information for compound 774041