Detailed information for compound 775789

Basic information

Technical information
  • TDR Targets ID: 775789
  • Name: 2-amino-4-(4-methylphenyl)-4H-benzo[h]chromen e-3-carbonitrile
  • MW: 312.365 | Formula: C21H16N2O
  • H donors: 1 H acceptors: 1 LogP: 4.91 Rotable bonds: 1
    Rule of 5 violations (Lipinski): 1
  • SMILES: N#CC1=C(N)Oc2c(C1c1ccc(cc1)C)ccc1c2cccc1
  • InChi: 1S/C21H16N2O/c1-13-6-8-15(9-7-13)19-17-11-10-14-4-2-3-5-16(14)20(17)24-21(23)18(19)12-22/h2-11,19H,23H2,1H3
  • InChiKey: VOWWIDJXXXPMDR-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 12X-0922

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni hypothetical protein 0.0063 0.0645 0.0645
Trypanosoma cruzi cysteine peptidase, putative 0.0079 0.0908 0.1367
Entamoeba histolytica cysteine proteinase, putative 0.0079 0.0908 1
Entamoeba histolytica cysteine protease, putative 0.0046 0.0368 0.4054
Onchocerca volvulus 0.0057 0.054 0.1131
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.042 0.6641 0.6641
Schistosoma mansoni lamin 0.0028 0.0061 0.0061
Brugia malayi Cathepsin L-like precursor 0.0079 0.0908 0.1367
Entamoeba histolytica cysteine protease, putative 0.0046 0.0368 0.4054
Loa Loa (eye worm) hypothetical protein 0.0248 0.3761 0.3761
Echinococcus granulosus cathepsin L cysteine proteinase 0.0079 0.0908 0.0908
Schistosoma mansoni hypothetical protein 0.0063 0.0645 0.0645
Leishmania major GTP-binding protein, putative 0.0043 0.0307 0.1473
Trichomonas vaginalis ran, putative 0.0043 0.0307 0.1495
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0079 0.0908 0.4419
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0043 0.0307 0.3383
Schistosoma mansoni cathepsin F (C01 family) 0.0057 0.054 0.054
Leishmania major importin beta-1 subunit, putative 0.0047 0.038 0.183
Entamoeba histolytica cysteine protease, putative 0.0046 0.0368 0.4054
Brugia malayi cathepsin B-like cysteine proteinase 0.042 0.6641 1
Onchocerca volvulus 0.0051 0.044 0.0923
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0079 0.0908 1
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.042 0.6641 0.6641
Trypanosoma cruzi cruzipain precursor, putative 0.0079 0.0908 0.1367
Echinococcus granulosus lamin dm0 0.0028 0.0061 0.0061
Echinococcus multilocularis lamin dm0 0.0028 0.0061 0.0061
Trypanosoma brucei importin beta-1 subunit, putative 0.0058 0.0564 0.273
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0039 0.0239 0.0359
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0079 0.0908 0.4419
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0043 0.0307 0.0462
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0079 0.0908 0.4419
Brugia malayi Papain family cysteine protease containing protein 0.0079 0.0908 0.1367
Loa Loa (eye worm) hypothetical protein 0.0057 0.054 0.054
Loa Loa (eye worm) hypothetical protein 0.0028 0.0061 0.0061
Schistosoma mansoni cathepsin F (C01 family) 0.0079 0.0908 0.0908
Schistosoma mansoni ran 0.0043 0.0307 0.0307
Echinococcus granulosus GPCR family 2 0.0063 0.0645 0.0645
Brugia malayi Calcium binding EGF domain containing protein 0.004 0.0259 0.039
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0048 0.0389 0.0389
Entamoeba histolytica cysteine proteinase, putative 0.0046 0.0368 0.4054
Trypanosoma cruzi cysteine peptidase (N-terminal), putative 0.0046 0.0368 0.0554
Schistosoma mansoni hypothetical protein 0.0352 0.5499 0.5499
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0079 0.0908 0.4419
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0079 0.0908 0.4419
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0079 0.0908 0.4405
Loa Loa (eye worm) hypothetical protein 0.042 0.6641 0.6641
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0039 0.0239 0.2629
Brugia malayi Calcitonin receptor-like protein seb-1 0.0199 0.2927 0.4409
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0063 0.0645 0.0972
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0079 0.0908 0.4405
Entamoeba histolytica cysteine proteinase 2 0.0046 0.0368 0.4054
Echinococcus granulosus cathepsin b 0.042 0.6641 0.6641
Leishmania major cysteine peptidase A (CPA) 0.0079 0.0908 0.4405
Brugia malayi Cathepsin L-like cysteine proteinase 0.0057 0.054 0.0813
Schistosoma mansoni ap endonuclease 0.0039 0.0239 0.0239
Entamoeba histolytica cysteine protease, putative 0.0046 0.0368 0.4054
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0079 0.0908 1
Loa Loa (eye worm) hypothetical protein 0.0309 0.477 0.477
Loa Loa (eye worm) hypothetical protein 0.004 0.0259 0.0259
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0079 0.0908 0.4419
Schistosoma mansoni hypothetical protein 0.0051 0.044 0.044
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0039 0.0239 0.0239
Onchocerca volvulus 0.0079 0.0908 0.1903
Onchocerca volvulus 0.0079 0.0908 0.1903
Trichomonas vaginalis ap endonuclease, putative 0.0039 0.0239 0.1162
Plasmodium vivax unspecified product 0.0046 0.0368 0.4054
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0079 0.0908 0.4419
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0079 0.0908 0.4405
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0051 0.044 0.0663
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0046 0.0368 0.0368
Entamoeba histolytica cysteine protease, putative 0.0046 0.0368 0.4054
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0079 0.0908 0.4419
Entamoeba histolytica Ran family GTPase 0.0043 0.0307 0.3383
Schistosoma mansoni intermediate filament proteins 0.0028 0.0061 0.0061
Entamoeba histolytica cysteine proteinase, putative 0.0079 0.0908 1
Echinococcus multilocularis cathepsin L cysteine protease 0.0079 0.0908 0.0908
Trypanosoma brucei importin beta-1 subunit, putative 0.0058 0.0564 0.273
Echinococcus granulosus geminin 0.0352 0.5499 0.5499
Entamoeba histolytica cysteine proteinase, putative 0.0046 0.0368 0.4054
Loa Loa (eye worm) ctsf protein 0.0079 0.0908 0.0908
Echinococcus multilocularis laminin 0.004 0.0259 0.0259
Brugia malayi Importin beta-1 subunit 0.0058 0.0564 0.085
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0039 0.0239 0.5
Brugia malayi Cathepsin L-like precursor 0.0079 0.0908 0.1367
Entamoeba histolytica cysteine proteinase 1, putative 0.0046 0.0368 0.4054
Onchocerca volvulus Arrow homolog 0.004 0.0259 0.0543
Leishmania major cathepsin L-like protease 0.0079 0.0908 0.4405
Loa Loa (eye worm) hypothetical protein 0.0057 0.054 0.054
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0079 0.0908 0.4419
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0079 0.0908 0.4405
Onchocerca volvulus Cathepsin L homolog 0.0079 0.0908 0.1903
Trypanosoma cruzi cysteine proteinase, putative 0.0046 0.0368 0.0554
Giardia lamblia Cathepsin B precursor 0.0147 0.2054 1
Toxoplasma gondii exonuclease III APE 0.0039 0.0239 0.1162
Loa Loa (eye worm) cathepsin B 0.0147 0.2054 0.2054
Loa Loa (eye worm) low-density lipoprotein receptor repeat class B containing protein 0.004 0.0259 0.0259
Echinococcus multilocularis cathepsin b 0.042 0.6641 0.6641
Plasmodium vivax vivapain-2 0.0079 0.0908 1
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.062 1 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0079 0.0908 0.4405
Entamoeba histolytica cysteine protease, putative 0.0046 0.0368 0.4054
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0039 0.0239 0.0359
Echinococcus multilocularis snurportin 1 0.062 1 1
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0043 0.0307 0.0462
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0048 0.0389 0.0389
Echinococcus granulosus cathepsin l1 0.0057 0.054 0.054
Treponema pallidum exodeoxyribonuclease (exoA) 0.0039 0.0239 0.5
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0063 0.0645 0.0645
Leishmania major cathepsin L-like protease 0.0079 0.0908 0.4405
Brugia malayi Latrophilin receptor protein 2 0.0063 0.0645 0.0972
Brugia malayi cathepsin L-like precursor 0.0057 0.054 0.0813
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0043 0.0307 0.1495
Schistosoma mansoni ap endonuclease 0.0039 0.0239 0.0239
Toxoplasma gondii calcium binding egf domain-containing protein 0.004 0.0259 0.126
Echinococcus multilocularis GPCR, family 2 0.0063 0.0645 0.0645
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0047 0.038 0.185
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0063 0.0645 0.0645
Schistosoma mansoni hypothetical protein 0.0063 0.0645 0.0645
Brugia malayi hypothetical protein 0.0309 0.477 0.7183
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0079 0.0908 0.0908
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0199 0.2927 0.2927
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0005 0.0008
Echinococcus multilocularis cathepsin L 0.0046 0.0368 0.0368
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0079 0.0908 0.4419
Echinococcus granulosus cathepsin l1 0.0079 0.0908 0.0908
Echinococcus granulosus cysteine protease 0.0046 0.0368 0.0368
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0046 0.0368 0.0368
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0079 0.0908 0.4419
Echinococcus granulosus GTP binding nuclear protein Ran 0.0043 0.0307 0.0307
Onchocerca volvulus Cathepsin F homolog 0.0079 0.0908 0.1903
Entamoeba histolytica cysteine protease, putative 0.0046 0.0368 0.4054
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0079 0.0908 0.0908
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0039 0.0239 0.0239
Brugia malayi Cathepsin L-like precursor 0.0079 0.0908 0.1367
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0039 0.0239 0.2629
Echinococcus granulosus intermediate filament protein 0.0028 0.0061 0.0061
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0048 0.0389 0.0389
Brugia malayi RNA, U transporter 1 0.0165 0.2362 0.3558
Entamoeba histolytica cysteine protease, putative 0.0046 0.0368 0.4054
Brugia malayi Fibulin-1 precursor 0.004 0.0259 0.039
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0043 0.0307 0.0307
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0079 0.0908 0.4419
Schistosoma mansoni lamin 0.0028 0.0061 0.0061
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0079 0.0908 0.4419
Echinococcus granulosus laminin 0.004 0.0259 0.0259
Trypanosoma brucei cysteine peptidase C (CPC) 0.0147 0.2054 1
Trypanosoma cruzi importin beta-1 subunit, putative 0.0047 0.038 0.0572
Giardia lamblia Cathepsin B precursor 0.0147 0.2054 1
Leishmania major cathepsin L-like protease 0.0079 0.0908 0.4405
Trypanosoma cruzi cysteine peptidase, putative 0.0046 0.0368 0.0554
Onchocerca volvulus Cathepsin L homolog 0.0079 0.0908 0.1903
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0079 0.0908 0.4419
Echinococcus granulosus cathepsin l cysteine peptidase 0.0079 0.0908 0.0908
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0039 0.0239 0.5
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0046 0.0368 0.1791
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0079 0.0908 0.4419
Plasmodium vivax vivapain-2 0.0079 0.0908 1
Plasmodium falciparum cysteine proteinase falcipain 3 0.0079 0.0908 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0057 0.054 0.2627
Loa Loa (eye worm) hypothetical protein 0.0057 0.054 0.054
Onchocerca volvulus 0.0079 0.0908 0.1903
Echinococcus granulosus cathepsin L 0.0046 0.0368 0.0368
Entamoeba histolytica cysteine protease, putative 0.0046 0.0368 0.4054
Loa Loa (eye worm) hypothetical protein 0.004 0.0259 0.0259
Trypanosoma cruzi cysteine peptidase, putative 0.0079 0.0908 0.1367
Schistosoma mansoni hypothetical protein 0.0136 0.1871 0.1871
Plasmodium falciparum cysteine proteinase falcipain 1 0.0046 0.0368 0.4054
Schistosoma mansoni subfamily M12A unassigned peptidase (M12 family) 0.004 0.0259 0.0259
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0039 0.0239 0.1162
Trypanosoma cruzi cysteine peptidase, putative 0.0079 0.0908 0.1367
Echinococcus multilocularis cathepsin L cysteine protease 0.0079 0.0908 0.0908
Entamoeba histolytica cysteine proteinase, putative 0.0046 0.0368 0.4054
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0048 0.0389 0.0586
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0147 0.2054 0.2054
Echinococcus granulosus cathepsin b 0.042 0.6641 0.6641
Toxoplasma gondii cathepsin CPL 0.0079 0.0908 0.4419
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0079 0.0908 0.4419
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0079 0.0908 0.4405
Toxoplasma gondii LsmAD domain-containing protein 0.0025 0.0005 0.0025
Toxoplasma gondii cathepsin B 0.0147 0.2054 1
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0043 0.0307 0.1495
Echinococcus granulosus importin subunit beta 1 0.0058 0.0564 0.0564
Onchocerca volvulus 0.0079 0.0908 0.1903
Schistosoma mansoni SmCB2 peptidase (C01 family) 0.042 0.6641 0.6641
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0039 0.0239 0.2629
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0039 0.0239 0.5
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0079 0.0908 0.4419
Echinococcus multilocularis musashi 0.0028 0.0061 0.0061
Loa Loa (eye worm) hypothetical protein 0.004 0.0259 0.0259
Trypanosoma cruzi cysteine protease, putative 0.0046 0.0368 0.0554
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0039 0.0239 0.1139
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0079 0.0908 0.4405
Loa Loa (eye worm) hypothetical protein 0.0028 0.0052 0.0052
Trypanosoma cruzi cysteine proteinase, putative 0.0046 0.0368 0.0554
Leishmania major cathepsin L-like protease 0.0079 0.0908 0.4405
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0079 0.0908 0.4419
Loa Loa (eye worm) latrophilin receptor protein 2 0.0063 0.0645 0.0645
Brugia malayi latrophilin 2 splice variant baaae 0.0136 0.1871 0.2818
Brugia malayi Papain family cysteine protease containing protein 0.0046 0.0368 0.0554
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0043 0.0307 0.3383
Plasmodium vivax vivapain-1 0.0046 0.0368 0.4054
Echinococcus multilocularis fibrillin 1 0.004 0.0259 0.0259
Brugia malayi intermediate filament protein 0.0028 0.0061 0.0091
Schistosoma mansoni egf-like domain protein 0.004 0.0259 0.0259
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0048 0.0389 0.0389
Echinococcus granulosus Tolloid protein 1 0.004 0.0259 0.0259
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0048 0.0389 0.0389
Plasmodium vivax vivapain-3 0.0046 0.0368 0.4054
Loa Loa (eye worm) hypothetical protein 0.0058 0.0564 0.0564
Entamoeba histolytica cysteine proteinase, putative 0.0057 0.054 0.5946
Brugia malayi exodeoxyribonuclease III family protein 0.0039 0.0239 0.0359
Brugia malayi Cathepsin L-like precursor 0.0079 0.0908 0.1367
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0057 0.054 0.2627
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.042 0.6641 0.6641
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0063 0.0645 0.0645
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0079 0.0908 0.0908
Entamoeba histolytica cysteine proteinase, putative 0.0046 0.0368 0.4054
Brugia malayi Cathepsin L-like precursor 0.0079 0.0908 0.1367
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0079 0.0908 0.4419
Brugia malayi hypothetical protein 0.0025 0.0005 0.0008
Schistosoma mansoni survival motor neuron protein 0.0051 0.044 0.044
Onchocerca volvulus 0.0028 0.0061 0.0127
Echinococcus granulosus survival motor neuron protein 1 0.0248 0.3761 0.3761
Entamoeba histolytica cysteine protease, putative 0.0046 0.0368 0.4054
Brugia malayi Low-density lipoprotein receptor repeat class B containing protein 0.004 0.0259 0.039
Echinococcus multilocularis importin subunit beta 1 0.0058 0.0564 0.0564
Loa Loa (eye worm) bone morphogenetic protein 1b 0.004 0.0259 0.0259
Echinococcus multilocularis cysteine protease 0.0079 0.0908 0.0908
Brugia malayi hypothetical protein 0.0248 0.3761 0.5664
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0043 0.0307 0.0462
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.042 0.6641 1
Onchocerca volvulus 0.0079 0.0908 0.1903
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0079 0.0908 0.4419
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0079 0.0908 0.4405
Loa Loa (eye worm) hypothetical protein 0.0136 0.1871 0.1871
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0079 0.0908 0.4405
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0046 0.0368 0.1791
Schistosoma mansoni cathepsin F (C01 family) 0.0079 0.0908 0.0908
Schistosoma mansoni hypothetical protein 0.0063 0.0645 0.0645
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0063 0.0645 0.0645
Loa Loa (eye worm) hypothetical protein 0.0063 0.0645 0.0645
Trichomonas vaginalis importin beta-1, putative 0.0047 0.038 0.185
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0039 0.0239 0.1139
Entamoeba histolytica cysteine protease, putative 0.0046 0.0368 0.4054
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0046 0.0368 0.0368
Echinococcus multilocularis survival motor neuron protein 1 0.0248 0.3761 0.3761
Echinococcus multilocularis geminin 0.0352 0.5499 0.5499
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0079 0.0908 0.0908
Entamoeba histolytica cysteine protease, putative 0.0046 0.0368 0.4054
Loa Loa (eye worm) fibroinase 0.0079 0.0908 0.0908
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0048 0.0389 0.0389
Echinococcus granulosus lamin 0.0028 0.0061 0.0061
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0079 0.0908 0.4419
Onchocerca volvulus 0.0079 0.0908 0.1903
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0199 0.2927 0.4409
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0039 0.0239 0.0239
Giardia lamblia Cathepsin B precursor 0.0147 0.2054 1
Loa Loa (eye worm) hypothetical protein 0.0025 0.0005 0.0005
Onchocerca volvulus 0.0309 0.477 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0079 0.0908 0.4405
Schistosoma mansoni hypothetical protein 0.062 1 1
Echinococcus multilocularis cysteine protease 0.0079 0.0908 0.0908
Loa Loa (eye worm) hypothetical protein 0.004 0.0259 0.0259
Echinococcus multilocularis cathepsin b 0.042 0.6641 0.6641
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0005 0.0008
Schistosoma mansoni importin beta-1 0.0058 0.0564 0.0564
Leishmania major cathepsin L-like protease 0.0079 0.0908 0.4405
Plasmodium vivax ataxin-2 like protein, putative 0.0025 0.0005 0.0057
Loa Loa (eye worm) cysteine protease 0.0079 0.0908 0.0908
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0005 0.0057
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0079 0.0908 0.4419
Leishmania major cathepsin L-like protease 0.0079 0.0908 0.4405
Loa Loa (eye worm) hypothetical protein 0.004 0.0259 0.0259
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0048 0.0389 0.0389
Entamoeba histolytica cysteine protease, putative 0.0079 0.0908 1
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0048 0.0389 0.0389
Brugia malayi Cathepsin L-like precursor 0.0057 0.054 0.0813
Toxoplasma gondii HEAT repeat-containing protein 0.0058 0.0564 0.2748
Brugia malayi Cathepsin L-like precursor 0.0057 0.054 0.0813
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0028 0.0061 0.0061
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0147 0.2054 1
Loa Loa (eye worm) multiple epidermal growth factor-like domains 6 0.004 0.0259 0.0259
Onchocerca volvulus 0.0079 0.0908 0.1903
Echinococcus multilocularis Tolloid protein 1 0.004 0.0259 0.0259
Leishmania major cathepsin L-like protease 0.0079 0.0908 0.4405
Brugia malayi Intermediate filament tail domain containing protein 0.0028 0.0061 0.0091
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0043 0.0307 0.0307
Leishmania major cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like 0.0147 0.2054 1
Schistosoma mansoni ran 0.0043 0.0307 0.0307
Trichomonas vaginalis ap endonuclease, putative 0.0039 0.0239 0.1162
Loa Loa (eye worm) intermediate filament protein 0.0028 0.0061 0.0061
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0046 0.0368 0.1771
Brugia malayi Cathepsin L-like precursor 0.0079 0.0908 0.1367
Loa Loa (eye worm) hypothetical protein 0.0199 0.2927 0.2927
Echinococcus multilocularis lamin 0.0028 0.0061 0.0061
Trypanosoma cruzi cysteine peptidase, putative 0.0079 0.0908 0.1367
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0046 0.0368 0.1771
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0079 0.0908 0.4405
Plasmodium falciparum importin beta, putative 0.0058 0.0564 0.622
Plasmodium vivax importin-beta 2, putative 0.0058 0.0564 0.622
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0043 0.0307 0.1473
Brugia malayi Papain family cysteine protease containing protein 0.0046 0.0368 0.0554
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0047 0.038 0.185
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0079 0.0908 0.4419
Schistosoma mansoni hypothetical protein 0.0352 0.5499 0.5499
Entamoeba histolytica hypothetical protein 0.0047 0.038 0.4187
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0005 0.0057
Loa Loa (eye worm) hypothetical protein 0.0079 0.0908 0.0908
Entamoeba histolytica cysteine protease, putative 0.0046 0.0368 0.4054
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0079 0.0908 0.4419
Echinococcus granulosus cathepsin L cysteine protease 0.0046 0.0368 0.0368
Onchocerca volvulus 0.0028 0.0061 0.0127
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0057 0.054 0.0813
Toxoplasma gondii calcium binding egf domain-containing protein 0.004 0.0259 0.126
Leishmania major cathepsin L-like protease 0.0079 0.0908 0.4405
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0079 0.0908 0.4419
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0147 0.2054 0.3093

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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