Detailed information for compound 776757

Basic information

Technical information
  • TDR Targets ID: 776757
  • Name: 7-[(4-hydroxy-3-methoxyphenyl)-[(4-methylpyri din-2-yl)amino]methyl]quinolin-8-ol
  • MW: 387.431 | Formula: C23H21N3O3
  • H donors: 3 H acceptors: 4 LogP: 4.25 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1cc(ccc1O)C(c1ccc2c(c1O)nccc2)Nc1nccc(c1)C
  • InChi: 1S/C23H21N3O3/c1-14-9-11-24-20(12-14)26-21(16-6-8-18(27)19(13-16)29-2)17-7-5-15-4-3-10-25-22(15)23(17)28/h3-13,21,27-28H,1-2H3,(H,24,26)
  • InChiKey: HKVBLSRMZHSZFQ-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 7-[(4-hydroxy-3-methoxy-phenyl)-[(4-methyl-2-pyridyl)amino]methyl]quinolin-8-ol
  • 7-[(4-hydroxy-3-methoxyphenyl)-[(4-methyl-2-pyridyl)amino]methyl]-8-quinolinol
  • 7-[(4-hydroxy-3-methoxy-phenyl)-[(4-methylpyridin-2-yl)amino]methyl]quinolin-8-ol
  • Oprea1_335062

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi Nuclear hormone receptor family member nhr-19 0.002 0.0213 0.0345
Trypanosoma cruzi trypanothione reductase, putative 0.0017 0.0135 0.0186
Plasmodium vivax thioredoxin reductase, putative 0.0048 0.084 1
Mycobacterium ulcerans aldehyde dehydrogenase 0.0061 0.1134 0.1706
Trypanosoma brucei PAB1-binding protein , putative 0.0026 0.0336 0.2988
Brugia malayi Nuclear hormone receptor family member nhr-40 0.002 0.0213 0.0345
Loa Loa (eye worm) hypothetical protein 0.0019 0.0199 0.0322
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0109 0.222 0.8844
Brugia malayi hypothetical protein 0.0026 0.0336 0.0546
Loa Loa (eye worm) hypothetical protein 0.0094 0.188 0.305
Brugia malayi Nuclear hormone receptor family member nhr-31 0.002 0.0213 0.0345
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.0135 0.0186
Brugia malayi Nuclear hormone receptor-like 1 0.002 0.0213 0.0345
Echinococcus multilocularis regulator of G protein signaling 3 0.0019 0.0199 0.0199
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0017 0.0135 0.0056
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0041 0.0691 0.0922
Plasmodium falciparum ataxin-2 like protein, putative 0.0026 0.0336 0.2988
Echinococcus granulosus nuclear receptor 2DBD gamma 0.002 0.0213 0.0213
Echinococcus multilocularis beta adrenergic receptor kinase 0.002 0.0215 0.0215
Echinococcus granulosus thioredoxin glutathione reductase 0.0048 0.084 0.084
Schistosoma mansoni retinoid-x-receptor (RXR) 0.002 0.0213 0.0345
Brugia malayi nuclear receptor NHR-88 0.002 0.0213 0.0345
Loa Loa (eye worm) hypothetical protein 0.002 0.0213 0.0345
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0037 0.0585 0.9314
Schistosoma mansoni regulator of G protein signaling 0.0019 0.0199 0.0322
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0037 0.0585 0.6456
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0017 0.0135 0.0132
Brugia malayi Kinase associated domain 1 family protein 0.0094 0.188 0.305
Echinococcus multilocularis Regulator of G protein signaling 20 0.0019 0.0199 0.0199
Loa Loa (eye worm) RGS-3 protein 0.0019 0.0199 0.0322
Schistosoma mansoni nuclear hormone receptor 0.002 0.0213 0.0345
Brugia malayi PXA domain containing protein 0.0019 0.0199 0.0322
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0199 0.0105
Giardia lamblia Histone acetyltransferase GCN5 0.0038 0.0614 1
Plasmodium vivax ataxin-2 like protein, putative 0.0026 0.0336 0.2988
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0017 0.0135 0.022
Schistosoma mansoni serine/threonine protein kinase 0.002 0.0215 0.0349
Echinococcus multilocularis serine:threonine protein kinase MARK2 0.0095 0.1896 0.1896
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.002 0.0213 0.0345
Mycobacterium ulcerans glutaminase 0.0277 0.5993 1
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.002 0.0213 0.0213
Brugia malayi Nuclear hormone receptor family member nhr-1 0.002 0.0213 0.0345
Schistosoma mansoni glutaminase 0.0277 0.5993 0.972
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.002 0.0213 0.0213
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.0135 0.0186
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0199 0.0105
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.002 0.0213 0.0345
Trypanosoma cruzi PAB1-binding protein , putative 0.0026 0.0336 0.2988
Schistosoma mansoni coup transcription factor 0.002 0.0213 0.0345
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0011 0.002 0.002
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.002 0.0213 0.0345
Brugia malayi nuclear hormone receptor 0.002 0.0213 0.0345
Loa Loa (eye worm) hypothetical protein 0.002 0.0213 0.0345
Echinococcus multilocularis serine:threonine protein kinase MARK2 0.0095 0.1896 0.1896
Plasmodium falciparum ataxin-2 like protein, putative 0.0026 0.0336 0.2988
Toxoplasma gondii LsmAD domain-containing protein 0.0026 0.0336 0.2118
Brugia malayi ecdysteroid receptor 0.002 0.0213 0.0345
Schistosoma mansoni serine/threonine protein kinase 0.002 0.0215 0.0349
Brugia malayi PXA domain containing protein 0.0019 0.0199 0.0322
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.002 0.0213 0.0345
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0061 0.1134 1
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0122 0.0122
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.0135 0.0186
Loa Loa (eye worm) glutaminase 2 0.0277 0.5993 0.972
Treponema pallidum exodeoxyribonuclease (exoA) 0.0037 0.0585 1
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0122 0.2495 1
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0037 0.0585 0.9405
Loa Loa (eye worm) hypothetical protein 0.0026 0.0336 0.0546
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0109 0.222 0.8844
Schistosoma mansoni aldehyde dehydrogenase 0.0061 0.1134 0.184
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0017 0.0135 0.0132
Brugia malayi steroid hormone receptor 0.002 0.0213 0.0345
Brugia malayi regulator of G-protein signaling egl-10 0.0019 0.0199 0.0322
Loa Loa (eye worm) glutaminase 0.0277 0.5993 0.972
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.002 0.0213 0.0345
Loa Loa (eye worm) AGC/GRK/BARK protein kinase 0.002 0.0215 0.0349
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0012 0.0036 0.0059
Echinococcus multilocularis A kinase anchor protein 10, mitochondrial 0.0019 0.0199 0.0199
Brugia malayi photoreceptor-specific nuclear receptor 0.002 0.0213 0.0345
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0019 0.0199 0.0322
Plasmodium falciparum glutathione reductase 0.0017 0.0135 0.0186
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0017 0.0135 0.0135
Echinococcus multilocularis isocitrate dehydrogenase 0.0016 0.0122 0.0122
Echinococcus granulosus retinoic acid receptor rxr beta a 0.002 0.0213 0.0213
Schistosoma mansoni thyroid hormone receptor 0.002 0.0213 0.0345
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0037 0.0585 0.1953
Loa Loa (eye worm) glutathione reductase 0.0048 0.084 0.1362
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0037 0.0585 0.0949
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0017 0.0135 0.0132
Schistosoma mansoni aldehyde dehydrogenase 0.0061 0.1134 0.184
Schistosoma mansoni steroid hormone receptor ad4bp 0.002 0.0213 0.0345
Trichomonas vaginalis ap endonuclease, putative 0.0037 0.0585 0.0746
Echinococcus multilocularis hypothetical protein 0.0094 0.188 0.188
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.002 0.0213 0.0213
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0017 0.0135 0.0186
Brugia malayi acetyltransferase, GNAT family protein 0.0141 0.2922 0.474
Echinococcus granulosus maternal embryonic leucine zipper kinase 0.0191 0.4047 0.4047
Loa Loa (eye worm) hypothetical protein 0.002 0.0213 0.0345
Loa Loa (eye worm) G protein signaling regulator EGL-10 0.0019 0.0199 0.0322
Trichomonas vaginalis glutaminase, putative 0.0277 0.5993 0.9714
Echinococcus granulosus regulator of G protein signaling 7 0.0019 0.0199 0.0199
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0037 0.0585 0.0585
Plasmodium falciparum thioredoxin reductase 0.0017 0.0135 0.0186
Brugia malayi Regulator of G protein signaling domain containing protein 0.0019 0.0199 0.0322
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0061 0.1134 0.1134
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.002 0.0213 0.0345
Schistosoma mansoni RAR-like nuclear receptor 0.002 0.0213 0.0345
Brugia malayi Nuclear hormone receptor family member nhr-41 0.002 0.0213 0.0345
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0122 0.2495 1
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.002 0.0213 0.0213
Echinococcus multilocularis regulator of G protein signaling 0.0019 0.0199 0.0199
Echinococcus multilocularis axis inhibition protein axin 0.0019 0.0199 0.0199
Onchocerca volvulus Bile acid receptor homolog 0.002 0.0213 0.5
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.002 0.0213 0.0345
Loa Loa (eye worm) isocitrate dehydrogenase 0.0016 0.0122 0.0198
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0016 0.0122 0.0122
Echinococcus granulosus ecdysone induced protein 78C 0.002 0.0213 0.0213
Echinococcus multilocularis ecdysone induced protein 78C 0.002 0.0213 0.0213
Echinococcus multilocularis regulator of G protein signaling 7 0.0019 0.0199 0.0199
Brugia malayi Thioredoxin reductase 0.0048 0.084 0.1362
Loa Loa (eye worm) acetyltransferase 0.0141 0.2922 0.474
Schistosoma mansoni hypothetical protein 0.0094 0.188 0.305
Trypanosoma cruzi trypanothione reductase, putative 0.0048 0.084 1
Schistosoma mansoni regulator of G protein signaling 3 rgs3 0.0019 0.0199 0.0322
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0017 0.0135 0.5
Schistosoma mansoni regulator of G protein signaling 0.0019 0.0199 0.0322
Brugia malayi hypothetical protein 0.0017 0.0133 0.0215
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0141 0.2922 0.474
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.0135 0.0186
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.002 0.0213 0.0345
Echinococcus granulosus neuropeptide receptor A26 0.0456 1 1
Trypanosoma cruzi PAB1-binding protein , putative 0.0026 0.0336 0.2988
Entamoeba histolytica acetyltransferase, GNAT family 0.0038 0.0614 1
Echinococcus multilocularis thyroid hormone receptor alpha 0.002 0.0213 0.0213
Echinococcus granulosus axis inhibition protein axin 0.0019 0.0199 0.0199
Echinococcus multilocularis thioredoxin glutathione reductase 0.0048 0.084 0.084
Schistosoma mansoni Tr4/Tr2 (homologue) 0.002 0.0213 0.0345
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0011 0.002 0.002
Echinococcus granulosus serine:threonine protein kinase MARK2 0.0095 0.1896 0.1896
Echinococcus granulosus regulator of G protein signaling 3 0.0019 0.0199 0.0199
Loa Loa (eye worm) PXA domain-containing protein 0.0019 0.0199 0.0322
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.002 0.0213 0.0213
Trypanosoma brucei trypanothione reductase 0.0048 0.084 1
Echinococcus granulosus histone acetyltransferase KAT2B 0.0041 0.0691 0.0691
Schistosoma mansoni z-protein (S1r protein) 0.0019 0.0199 0.0322
Schistosoma mansoni regulator of G protein signaling 0.0019 0.0199 0.0322
Loa Loa (eye worm) AGC/GRK/GRK protein kinase 0.002 0.0215 0.0349
Brugia malayi Nuclear hormone receptor family member nhr-49 0.002 0.0213 0.0345
Brugia malayi Isocitrate dehydrogenase 0.0016 0.0122 0.0198
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.002 0.0213 0.5
Loa Loa (eye worm) steroid hormone receptor 0.002 0.0213 0.0345
Schistosoma mansoni serine/threonine protein kinase 0.002 0.0215 0.0349
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0122 0.0122
Brugia malayi glutaminase DH11.1 0.0277 0.5993 0.972
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.002 0.0213 0.0345
Echinococcus granulosus calcium activated potassium channel 0.0095 0.1896 0.1896
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0037 0.0585 0.0768
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0017 0.0135 0.0186
Loa Loa (eye worm) hypothetical protein 0.002 0.0213 0.0345
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.002 0.0213 0.0345
Toxoplasma gondii thioredoxin reductase 0.0048 0.084 0.7088
Onchocerca volvulus Protein ultraspiracle homolog 0.002 0.0213 0.5
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0016 0.0122 0.0122
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.0135 0.0186
Schistosoma mansoni serine/threonine protein kinase 0.0095 0.1896 0.3076
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0041 0.0691 0.5622
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0037 0.0585 0.4576
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0037 0.0585 1
Onchocerca volvulus 0.002 0.0213 0.5
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0019 0.0199 0.0322
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0061 0.1134 0.4267
Brugia malayi Nuclear hormone receptor family member nhr-14 0.002 0.0213 0.0345
Echinococcus granulosus axis inhibition protein axin 0.0019 0.0199 0.0199
Trichomonas vaginalis CAMK family protein kinase 0.0191 0.4047 0.6487
Brugia malayi regulator of G-protein signaling rgs-7 0.0019 0.0199 0.0322
Brugia malayi hypothetical protein 0.0019 0.0199 0.0322
Loa Loa (eye worm) CAMK/CAMKL/MELK protein kinase 0.0285 0.6165 1
Mycobacterium ulcerans aldehyde dehydrogenase 0.0061 0.1134 0.1706
Plasmodium falciparum glutathione reductase 0.0048 0.084 1
Schistosoma mansoni axis inhibition protein axin 0.0019 0.0199 0.0322
Loa Loa (eye worm) hypothetical protein 0.0019 0.0199 0.0322
Mycobacterium tuberculosis Probable reductase 0.0109 0.222 0.8844
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.002 0.0213 0.0213
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0017 0.0135 0.0186
Leishmania major hypothetical protein, conserved 0.0026 0.0336 0.2118
Plasmodium falciparum histone acetyltransferase GCN5 0.0038 0.0614 0.6853
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0037 0.0585 0.6456
Echinococcus granulosus Regulator of G protein signaling 20 0.0019 0.0199 0.0199
Trichomonas vaginalis ap endonuclease, putative 0.0037 0.0585 0.0746
Loa Loa (eye worm) hypothetical protein 0.002 0.0213 0.0345
Brugia malayi Regulator of G protein signaling domain containing protein 0.0019 0.0199 0.0322
Mycobacterium ulcerans aldehyde dehydrogenase 0.0061 0.1134 0.1706
Schistosoma mansoni ap endonuclease 0.0037 0.0585 0.0949
Loa Loa (eye worm) hypothetical protein 0.0019 0.0199 0.0322
Trichomonas vaginalis bromodomain-containing protein, putative 0.0041 0.0691 0.0922
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0122 0.2495 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.002 0.0213 0.0345
Loa Loa (eye worm) hypothetical protein 0.002 0.0213 0.0345
Schistosoma mansoni regulator of G protein signaling 0.0019 0.0199 0.0322
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0017 0.0135 0.0186
Brugia malayi Nuclear hormone receptor family member nhr-3 0.002 0.0213 0.0345
Echinococcus multilocularis FTZ F1 alpha 0.002 0.0213 0.0213
Echinococcus multilocularis axis inhibition protein axin 0.0019 0.0199 0.0199
Loa Loa (eye worm) hypothetical protein 0.002 0.0213 0.0345
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0048 0.084 0.3025
Echinococcus granulosus FTZ F1 alpha 0.002 0.0213 0.0213
Brugia malayi A-kinase anchor protein 10, precursor 0.0019 0.0199 0.0322
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0041 0.0691 0.7932
Loa Loa (eye worm) hypothetical protein 0.0019 0.0199 0.0322
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0037 0.0585 0.6456
Schistosoma mansoni ap endonuclease 0.0037 0.0585 0.0949
Echinococcus multilocularis regulator of G protein signaling 7 0.0019 0.0199 0.0199
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0017 0.0135 0.0186
Brugia malayi Protein kinase domain containing protein 0.0285 0.6165 1
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0017 0.0135 0.0186
Echinococcus multilocularis neuropeptide s receptor 0.0456 1 1
Brugia malayi glutathione reductase 0.0048 0.084 0.1362
Echinococcus granulosus expressed protein 0.0379 0.827 0.827
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.0135 0.0186
Echinococcus multilocularis maternal embryonic leucine zipper kinase 0.0191 0.4047 0.4047
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.002 0.0213 0.0345
Schistosoma mansoni hypothetical protein 0.0011 0.002 0.0032
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.002 0.0213 0.0213
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0199 0.0105
Trichomonas vaginalis CAMK family protein kinase 0.0285 0.6165 1
Loa Loa (eye worm) hypothetical protein 0.0019 0.0199 0.0322
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0037 0.0585 0.6456
Echinococcus granulosus A kinase anchor protein 10 mitochondrial 0.0019 0.0199 0.0199
Echinococcus multilocularis expressed protein 0.0379 0.827 0.827
Schistosoma mansoni serine/threonine protein kinase 0.0095 0.1896 0.3076
Echinococcus multilocularis calcium activated potassium channel 0.0095 0.1896 0.1896
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0037 0.0585 0.0585
Echinococcus multilocularis neuropeptide receptor A26 0.0456 1 1
Echinococcus granulosus serine:threonine protein kinase MARK2 0.0095 0.1896 0.1896
Echinococcus granulosus histone acetyltransferase KAT2B 0.0137 0.2833 0.2833
Schistosoma mansoni serine/threonine protein kinase 0.0095 0.1896 0.3076
Brugia malayi Nuclear hormone receptor family member nhr-19 0.002 0.0213 0.0345
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0109 0.222 0.8844
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0017 0.0135 0.0132
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0041 0.0691 0.5622
Toxoplasma gondii exonuclease III APE 0.0037 0.0585 0.4576
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.002 0.0213 0.0213
Schistosoma mansoni thyroid hormone receptor 0.002 0.0213 0.0345
Schistosoma mansoni regulator of G protein signaling 0.0019 0.0199 0.0322
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0017 0.0135 0.0132
Mycobacterium tuberculosis Probable oxidoreductase 0.0122 0.2495 1
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0199 0.0105
Echinococcus multilocularis regulator of G protein signaling 3 0.0019 0.0199 0.0199
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0017 0.0135 0.0186
Brugia malayi Nuclear hormone receptor family member nhr-25 0.002 0.0213 0.0345
Echinococcus granulosus regulator of G protein signaling 3 0.0019 0.0199 0.0199
Brugia malayi Steroid receptor seven-up type 2 0.002 0.0213 0.0345
Echinococcus granulosus beta-adrenergic receptor kinase 0.002 0.0215 0.0215
Echinococcus granulosus nuclear receptor 2DBD gamma 0.002 0.0213 0.0213
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0012 0.0036 0.0059
Loa Loa (eye worm) hypothetical protein 0.0019 0.0199 0.0322
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0017 0.0135 0.0186
Brugia malayi isocitrate dehydrogenase 0.0016 0.0122 0.0198
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0017 0.0135 0.022
Trichomonas vaginalis regulator of G protein signaling 5, rgs5, putative 0.0019 0.0199 0.0105
Loa Loa (eye worm) hypothetical protein 0.002 0.0213 0.0345
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0122 0.0122
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0199 0.0105
Schistosoma mansoni serine/threonine kinase 0.0285 0.6165 1
Loa Loa (eye worm) thioredoxin reductase 0.0048 0.084 0.1362
Plasmodium falciparum thioredoxin reductase 0.0048 0.084 1
Toxoplasma gondii aldehyde dehydrogenase 0.0061 0.1134 1
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.002 0.0213 0.0213
Schistosoma mansoni hypothetical protein 0.0094 0.188 0.305
Brugia malayi Nuclear hormone receptor family member nhr-25 0.002 0.0213 0.0345
Toxoplasma gondii NADPH-glutathione reductase 0.0017 0.0135 0.0132
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.002 0.0213 0.0345
Echinococcus granulosus regulator of G protein signaling 7 0.0019 0.0199 0.0199
Trichomonas vaginalis CAMK family protein kinase 0.0191 0.4047 0.6487
Leishmania major trypanothione reductase 0.0048 0.084 0.7088
Schistosoma mansoni serine/threonine protein kinase 0.0095 0.1896 0.3076
Plasmodium vivax glutathione reductase, putative 0.0048 0.084 1
Brugia malayi hypothetical protein 0.0019 0.0199 0.0322
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.002 0.0213 0.0213
Schistosoma mansoni serine/threonine protein kinase 0.0095 0.1896 0.3076
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0141 0.2922 0.2922
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0061 0.1134 0.1134
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0017 0.0135 0.0135
Brugia malayi Probable G protein-coupled receptor kinase F19C6.1, putative 0.002 0.0215 0.0349
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0109 0.222 0.8844
Schistosoma mansoni axis inhibition protein axin 0.0019 0.0199 0.0322
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0037 0.0585 0.6456
Schistosoma mansoni retinoic acid receptor RXR 0.002 0.0213 0.0345
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0017 0.0135 0.0186
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0199 0.0105
Mycobacterium tuberculosis Probable dehydrogenase 0.0109 0.222 0.8844
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0017 0.0135 0.0186
Brugia malayi exodeoxyribonuclease III family protein 0.0037 0.0585 0.0949
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0016 0.0122 0.0198

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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