TDR Targets

Basic information

Technical information

TDR Targets ID: 783267
Name: N-(4-ethoxyphenyl)-7-methyl-5-oxo-[1,3]thiazo lo[3,2-a]pyrimidine-6-sulfonamide
MW: 365.427 | Formula: C15H15N3O4S2
H donors: 1 H acceptors: 3 LogP: 1.62 Rotable bonds: 5
Rule of 5 violations (Lipinski): 1
SMILES: CCOc1ccc(cc1)NS(=O)(=O)c1c(C)nc2n(c1=O)ccs2
InChi: 1S/C15H15N3O4S2/c1-3-22-12-6-4-11(5-7-12)17-24(20,21)13-10(2)16-15-18(14(13)19)8-9-23-15/h4-9,17H,3H2,1-2H3
InChiKey: ROUVWYPXBITHLI-UHFFFAOYSA-N

Network

Hover on a compound node to display the structore

Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

This is a work in progress. Come back soon to try this features!

Clustering layers

This is a work in progress. Come back soon to try this features!

Synonyms

N-(4-ethoxyphenyl)-7-methyl-5-oxo-thiazolo[3,2-a]pyrimidine-6-sulfonamide
N-(4-ethoxyphenyl)-7-methyl-5-oxo-6-thiazolo[3,2-a]pyrimidinesulfonamide
N-(4-ethoxyphenyl)-5-keto-7-methyl-thiazolo[3,2-a]pyrimidine-6-sulfonamide
ZINC06784620

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	TAR DNA binding protein	Starlite/ChEMBL	No references
Homo sapiens	ataxin 2	Starlite/ChEMBL	No references
Homo sapiens	SMAD family member 2	Starlite/ChEMBL	No references
Homo sapiens	K(lysine) acetyltransferase 2A	Starlite/ChEMBL	No references
Mus musculus	RAR-related orphan receptor gamma	Starlite/ChEMBL	No references

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Candida albicans	bromodomain protein similar to S. cerevisiae GCN5 (YGR252W) histone acetyltransferase	Get druggable targets OG5_127781	All targets in OG5_127781
Schistosoma japonicum	TAR DNA-binding protein 43, putative	Get druggable targets OG5_132461	All targets in OG5_132461
Echinococcus multilocularis	tar DNA binding protein	Get druggable targets OG5_132461	All targets in OG5_132461
Plasmodium berghei	histone acetyltransferase GCN5, putative	Get druggable targets OG5_127781	All targets in OG5_127781
Giardia lamblia	Histone acetyltransferase GCN5	Get druggable targets OG5_127781	All targets in OG5_127781
Loa Loa (eye worm)	acetyltransferase	Get druggable targets OG5_127781	All targets in OG5_127781
Brugia malayi	RNA binding protein	Get druggable targets OG5_132461	All targets in OG5_132461
Loa Loa (eye worm)	RNA recognition domain-containing protein domain-containing protein	Get druggable targets OG5_132461	All targets in OG5_132461
Schistosoma mansoni	tar DNA-binding protein	Get druggable targets OG5_132461	All targets in OG5_132461
Theileria parva	histone acetyltransferase Gcn5, putative	Get druggable targets OG5_127781	All targets in OG5_127781
Loa Loa (eye worm)	MH2 domain-containing protein	Get druggable targets OG5_131716	All targets in OG5_131716
Babesia bovis	histone acetyltransferase	Get druggable targets OG5_127781	All targets in OG5_127781
Schistosoma mansoni	tar DNA-binding protein	Get druggable targets OG5_132461	All targets in OG5_132461
Plasmodium falciparum	histone acetyltransferase GCN5	Get druggable targets OG5_127781	All targets in OG5_127781
Loa Loa (eye worm)	TAR-binding protein	Get druggable targets OG5_132461	All targets in OG5_132461
Brugia malayi	acetyltransferase, GNAT family protein	Get druggable targets OG5_127781	All targets in OG5_127781
Loa Loa (eye worm)	transcription factor SMAD2	Get druggable targets OG5_131716	All targets in OG5_131716
Candida albicans	bromodomain protein similar to S. cerevisiae GCN5 (YGR252W) histone acetyltransferase	Get druggable targets OG5_127781	All targets in OG5_127781
Schistosoma japonicum	TAR DNA-binding protein 43, putative	Get druggable targets OG5_132461	All targets in OG5_132461
Toxoplasma gondii	histone lysine acetyltransferase GCN5-B	Get druggable targets OG5_127781	All targets in OG5_127781
Trichomonas vaginalis	cat eye syndrome critical region protein 2, cscr2, putative	Get druggable targets OG5_127781	All targets in OG5_127781
Echinococcus granulosus	histone acetyltransferase KAT2B	Get druggable targets OG5_127781	All targets in OG5_127781
Schistosoma mansoni	tar DNA-binding protein	Get druggable targets OG5_132461	All targets in OG5_132461
Neospora caninum	hypothetical protein	Get druggable targets OG5_127781	All targets in OG5_127781
Echinococcus multilocularis	gcn5proteinral control of amino acid synthesis	Get druggable targets OG5_127781	All targets in OG5_127781
Schistosoma mansoni	gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2	Get druggable targets OG5_127781	All targets in OG5_127781
Echinococcus granulosus	tar DNA binding protein	Get druggable targets OG5_132461	All targets in OG5_132461
Neospora caninum	Bromodomain containing protein, related	Get druggable targets OG5_127781	All targets in OG5_127781
Schistosoma mansoni	tar DNA-binding protein	Get druggable targets OG5_132461	All targets in OG5_132461
Loa Loa (eye worm)	RNA binding protein	Get druggable targets OG5_132461	All targets in OG5_132461
Schistosoma mansoni	tar DNA-binding protein	Get druggable targets OG5_132461	All targets in OG5_132461
Toxoplasma gondii	histone lysine acetyltransferase GCN5-A	Get druggable targets OG5_127781	All targets in OG5_127781
Echinococcus granulosus	histone acetyltransferase KAT2B	Get druggable targets OG5_127781	All targets in OG5_127781
Entamoeba histolytica	acetyltransferase, GNAT family	Get druggable targets OG5_127781	All targets in OG5_127781
Trichomonas vaginalis	bromodomain-containing protein, putative	Get druggable targets OG5_127781	All targets in OG5_127781
Cryptosporidium hominis	histone acetyltransferase	Get druggable targets OG5_127781	All targets in OG5_127781
Schistosoma japonicum	ko:K06062 p300/CBP-associated factor, putative	Get druggable targets OG5_127781	All targets in OG5_127781
Plasmodium yoelii	histone acetyltransferase GCN5-related	Get druggable targets OG5_127781	All targets in OG5_127781
Plasmodium vivax	histone acetyltransferase GCN5, putative	Get druggable targets OG5_127781	All targets in OG5_127781
Cryptosporidium parvum	GCN5 like acetylase + bromodomain	Get druggable targets OG5_127781	All targets in OG5_127781
Plasmodium knowlesi	histone acetyltransferase GCN5, putative	Get druggable targets OG5_127781	All targets in OG5_127781
Brugia malayi	MH2 domain containing protein	Get druggable targets OG5_131716	All targets in OG5_131716
Brugia malayi	RNA recognition motif domain containing protein	Get druggable targets OG5_132461	All targets in OG5_132461
Brugia malayi	TAR-binding protein	Get druggable targets OG5_132461	All targets in OG5_132461

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Brugia malayi	MH2 domain containing protein	SMAD family member 2	467 aa	405 aa	31.6 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Loa Loa (eye worm)	RNA binding protein	0.0076	0.1183	0.102
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0037	0.0356	0.0178
Schistosoma mansoni	jumonji/arid domain-containing protein	0.0034	0.0305	0.0126
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0356	0.0178
Plasmodium falciparum	ATP-dependent 6-phosphofructokinase	0.003	0.0215	0.0854
Schistosoma mansoni	tar DNA-binding protein	0.0076	0.1183	0.102
Echinococcus multilocularis	gcn5proteinral control of amino acid synthesis	0.0175	0.3234	0.3109
Trichomonas vaginalis	D-aminoacylase, putative	0.0037	0.0356	0.0266
Schistosoma mansoni	tar DNA-binding protein	0.0076	0.1183	0.102
Entamoeba histolytica	acetyltransferase, GNAT family	0.0047	0.0573	0.0677
Loa Loa (eye worm)	beta-LACTamase domain containing family member	0.0037	0.0356	0.0178
Trypanosoma brucei	hypothetical protein, conserved	0.0037	0.0356	0.0783
Loa Loa (eye worm)	jmjC domain-containing protein	0.0034	0.0305	0.0126
Brugia malayi	beta-lactamase family protein	0.0037	0.0356	0.0356
Brugia malayi	beta-lactamase	0.0037	0.0356	0.0356
Giardia lamblia	Histone acetyltransferase GCN5	0.0047	0.0573	0.0735
Loa Loa (eye worm)	6-phosphofructokinase	0.0111	0.19	0.175
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0281	0.0102
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0045	0.0533	0.0358
Echinococcus granulosus	Transcription factor JmjC domain containing protein	0.0093	0.1524	0.1368
Onchocerca volvulus		0.0037	0.0356	0.0178
Leishmania major	hypothetical protein, conserved	0.0037	0.0356	0.0783
Toxoplasma gondii	6-phosphofructokinase	0.003	0.0215	0.0695
Loa Loa (eye worm)	phosphofructokinase	0.0111	0.19	0.175
Plasmodium falciparum	ataxin-2 like protein, putative	0.003	0.0225	0.1104
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0356	0.0178
Onchocerca volvulus		0.0154	0.28	0.2668
Echinococcus multilocularis	6 phosphofructokinase	0.0111	0.19	0.175
Onchocerca volvulus		0.0037	0.0356	0.0178
Echinococcus multilocularis	Transcription factor, JmjC domain containing protein	0.0093	0.1524	0.1368
Plasmodium vivax	ataxin-2 like protein, putative	0.003	0.0225	0.0899
Brugia malayi	hypothetical protein	0.0154	0.28	0.28
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0045	0.0533	0.0533
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0284	0.5509	1
Giardia lamblia	Pyrophosphate-fructose 6-phosphate 1-phosphotransferase alpha subunit	0.003	0.0215	0.0063
Trichomonas vaginalis	phosphofructokinase, putative	0.0111	0.19	0.3183
Onchocerca volvulus		0.0037	0.0356	0.0178
Brugia malayi	Bromodomain containing protein	0.0033	0.0271	0.0271
Schistosoma mansoni	tar DNA-binding protein	0.0076	0.1183	0.102
Echinococcus multilocularis	jumonji domain containing protein	0.0039	0.0412	0.0235
Loa Loa (eye worm)	hypothetical protein	0.003	0.0225	0.0044
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0045	0.0533	0.0358
Mycobacterium leprae	Probable fructose bisphosphate aldolase Fba	0.0139	0.2482	1
Echinococcus granulosus	histone acetyltransferase KAT2B	0.0051	0.0662	0.049
Plasmodium vivax	histone acetyltransferase GCN5, putative	0.0051	0.0662	1
Schistosoma mansoni	tar DNA-binding protein	0.0076	0.1183	0.102
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0356	0.0178
Brugia malayi	latrophilin 2 splice variant baaae	0.0033	0.0281	0.0281
Schistosoma mansoni	tar DNA-binding protein	0.0076	0.1183	0.102
Loa Loa (eye worm)	MH2 domain-containing protein	0.0144	0.2592	0.2455
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0356	0.0178
Brugia malayi	beta-lactamase family protein	0.0037	0.0356	0.0356
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0045	0.0533	0.0358
Toxoplasma gondii	histone lysine acetyltransferase GCN5-B	0.0051	0.0662	1
Loa Loa (eye worm)	acetyltransferase	0.0175	0.3234	0.3109
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0045	0.0533	0.0358
Trichomonas vaginalis	bromodomain-containing protein, putative	0.0051	0.0662	0.0845
Plasmodium falciparum	ATP-dependent 6-phosphofructokinase	0.003	0.0215	0.0854
Brugia malayi	hypothetical protein	0.003	0.0225	0.0225
Schistosoma mansoni	vesicular acetylcholine transporter	0.05	1	1
Echinococcus granulosus	jumonji domain containing protein	0.0039	0.0412	0.0235
Brugia malayi	RNA binding protein	0.0076	0.1183	0.1183
Plasmodium falciparum	ataxin-2 like protein, putative	0.003	0.0225	0.1104
Loa Loa (eye worm)	TAR-binding protein	0.0076	0.1183	0.102
Toxoplasma gondii	phosphofructokinase PFKII	0.003	0.0215	0.0695
Brugia malayi	jmjC domain containing protein	0.0034	0.0305	0.0305
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0284	0.5509	1
Plasmodium vivax	hypothetical protein, conserved	0.0037	0.0356	0.3627
Trichomonas vaginalis	cat eye syndrome critical region protein 2, cscr2, putative	0.0051	0.0662	0.0845
Entamoeba histolytica	fructose-1,6-bisphosphate aldolase, putative	0.0284	0.5509	1
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0356	0.0178
Loa Loa (eye worm)	hypothetical protein	0.0048	0.06	0.0427
Echinococcus granulosus	tar DNA binding protein	0.0076	0.1183	0.102
Echinococcus granulosus	vesicular acetylcholine transporter	0.05	1	1
Onchocerca volvulus	Vesicular acetylcholine transporter homolog	0.05	1	1
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0284	0.5509	1
Mycobacterium tuberculosis	Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase)	0.0111	0.19	0.3747
Toxoplasma gondii	ABC1 family protein	0.0037	0.0356	0.3627
Trichomonas vaginalis	phosphofructokinase, putative	0.0111	0.19	0.3183
Trichomonas vaginalis	penicillin-binding protein, putative	0.0037	0.0356	0.0266
Schistosoma mansoni	6-phosphofructokinase	0.0111	0.19	0.175
Schistosoma mansoni	jumonji/arid domain-containing protein	0.0034	0.0305	0.0126
Brugia malayi	PHD-finger family protein	0.0028	0.0181	0.0181
Leishmania major	ATP-dependent phosphofructokinase	0.0111	0.19	1
Trichomonas vaginalis	phosphofructokinase, putative	0.0111	0.19	0.3183
Echinococcus granulosus	histone acetyltransferase KAT2B	0.017	0.3132	0.3005
Mycobacterium tuberculosis	Probable fructose-bisphosphate aldolase Fba	0.0139	0.2482	0.5159
Brugia malayi	RNA recognition motif domain containing protein	0.0076	0.1183	0.1183
Brugia malayi	Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative	0.0037	0.0356	0.0356
Echinococcus multilocularis	geminin	0.0165	0.3022	0.2893
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0045	0.0533	0.0358
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0356	0.0178
Echinococcus granulosus	peregrin	0.0033	0.0271	0.0091
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0284	0.5509	1
Entamoeba histolytica	phosphofructokinase, putative	0.0111	0.19	0.3183
Echinococcus granulosus	6 phosphofructokinase	0.0111	0.19	0.175
Entamoeba histolytica	phosphofructokinase, putative	0.0111	0.19	0.3183
Schistosoma mansoni	hypothetical protein	0.0033	0.0281	0.0102
Brugia malayi	6-phosphofructokinase	0.0111	0.19	0.19
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0045	0.0533	0.0358
Schistosoma mansoni	6-phosphofructokinase	0.0111	0.19	0.175
Brugia malayi	acetyltransferase, GNAT family protein	0.0175	0.3234	0.3234
Schistosoma mansoni	gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2	0.0175	0.3234	0.3109
Echinococcus multilocularis	peregrin	0.0033	0.0271	0.0091
Plasmodium falciparum	histone acetyltransferase GCN5	0.0047	0.0573	1
Treponema pallidum	fructose-bisphosphate aldolase	0.0284	0.5509	1
Mycobacterium tuberculosis	Possible penicillin-binding protein	0.0235	0.4477	1
Echinococcus granulosus	geminin	0.0165	0.3022	0.2893
Echinococcus granulosus	lysine specific demethylase 5A	0.0034	0.0305	0.0126
Brugia malayi	jmjC domain containing protein	0.0093	0.1524	0.1524
Mycobacterium leprae	PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE)	0.0111	0.19	0.7262
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0045	0.0533	0.0358
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0284	0.5509	1
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0284	0.5509	1
Loa Loa (eye worm)	hypothetical protein	0.0154	0.28	0.2668
Loa Loa (eye worm)	jmjC domain-containing protein	0.0059	0.081	0.064
Toxoplasma gondii	phosphofructokinase domain-containing protein	0.003	0.0215	0.0695
Trichomonas vaginalis	D-aminoacylase, putative	0.0037	0.0356	0.0266
Loa Loa (eye worm)	beta-lactamase	0.0037	0.0356	0.0178
Entamoeba histolytica	phosphofructokinase, putative	0.0111	0.19	0.3183
Chlamydia trachomatis	fructose-6-phosphate phosphotransferase	0.003	0.0215	0.5
Toxoplasma gondii	LsmAD domain-containing protein	0.003	0.0225	0.0899
Loa Loa (eye worm)	6-phosphofructokinase	0.0111	0.19	0.175
Chlamydia trachomatis	fructose-6-phosphate phosphotransferase	0.003	0.0215	0.5
Loa Loa (eye worm)	hypothetical protein	0.0049	0.0603	0.0429
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0284	0.5509	1
Trypanosoma cruzi	ATP-dependent 6-phosphofructokinase, glycosomal	0.0111	0.19	1
Mycobacterium ulcerans	6-phosphofructokinase	0.0111	0.19	0.7262
Trichomonas vaginalis	D-aminoacylase, putative	0.0037	0.0356	0.0266
Mycobacterium ulcerans	fructose-bisphosphate aldolase	0.0139	0.2482	1
Brugia malayi	6-phosphofructokinase	0.0111	0.19	0.19
Trypanosoma cruzi	hypothetical protein, conserved	0.0037	0.0356	0.0783
Loa Loa (eye worm)	vesicular acetylcholine transporter unc-17	0.05	1	1
Schistosoma mansoni	jumonji domain containing protein	0.0074	0.1127	0.0963
Echinococcus multilocularis	vesicular acetylcholine transporter	0.05	1	1
Schistosoma mansoni	hypothetical protein	0.0165	0.3022	0.2893
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0048	0.06	0.0427
Plasmodium vivax	6-phosphofructokinase, putative	0.003	0.0215	0.0695
Echinococcus multilocularis	beta LACTamase domain containing family member	0.0037	0.0356	0.0178
Trichomonas vaginalis	phosphofructokinase, putative	0.0111	0.19	0.3183
Echinococcus multilocularis	tar DNA binding protein	0.0076	0.1183	0.102
Loa Loa (eye worm)	transcription factor SMAD2	0.0144	0.2592	0.2455
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0048	0.06	0.06
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0037	0.0356	0.0178
Brugia malayi	phosphofructokinase	0.0111	0.19	0.19
Echinococcus granulosus	beta LACTamase domain containing family member	0.0037	0.0356	0.0178
Giardia lamblia	Fructose-bisphosphate aldolase	0.0284	0.5509	1
Trichomonas vaginalis	penicillin-binding protein, putative	0.0037	0.0356	0.0266
Brugia malayi	MH2 domain containing protein	0.0144	0.2592	0.2592
Brugia malayi	TAR-binding protein	0.0076	0.1183	0.1183
Entamoeba histolytica	fructose-1,6-bisphosphate aldolase, putative	0.0284	0.5509	1
Treponema pallidum	diphosphate--fructose-6-phosphate 1-phosphotransferase	0.0111	0.19	0.3183
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0284	0.5509	1
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0045	0.0533	0.0358
Trichomonas vaginalis	esterase, putative	0.0037	0.0356	0.0266
Echinococcus multilocularis	lysine specific demethylase 5A	0.0034	0.0305	0.0126
Plasmodium vivax	6-phosphofructokinase, putative	0.003	0.0215	0.0695
Schistosoma mansoni	hypothetical protein	0.0165	0.3022	0.2893
Trypanosoma cruzi	hypothetical protein, conserved	0.0037	0.0356	0.0783
Toxoplasma gondii	histone lysine acetyltransferase GCN5-A	0.0051	0.0662	1
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0048	0.06	0.06
Loa Loa (eye worm)	RNA recognition domain-containing protein domain-containing protein	0.0076	0.1183	0.102
Trypanosoma brucei	ATP-dependent 6-phosphofructokinase, glycosomal	0.0111	0.19	1

Activities

Activity type	Activity value	Assay description	Source	Reference
Potency (functional)	0.3696 uM	PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850]	ChEMBL.	No reference
Potency (functional)	0.631 uM	PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of GCN5L2. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504398]	ChEMBL.	No reference
Potency (functional)	1 uM	PubChem BioAssay. qHTS for Inhibitors of ATXN expression. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	11.2202 uM	PubChem BioAssay. qHTS of TDP-43 Inhibitors. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	= 19.9526 um	PUBCHEM_BIOASSAY: qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	19.9526 uM	PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860]	ChEMBL.	No reference
Potency (functional)	28.1838 uM	PubChem BioAssay. qHTS Assay for Activators of ClpP. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	31.6228 uM	PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b: Cytotox Counterscreen. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588855, AID588860]	ChEMBL.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name	Source	Reference	Is orphan
Plasmodium falciparum	ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1368135
Search by Saint Jude

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 783267