Detailed information for compound 790904

Basic information

Technical information
  • TDR Targets ID: 790904
  • Name: N-(3-acetylphenyl)-1-(4-chlorophenyl)sulfonyl cyclopropane-1-carboxamide
  • MW: 377.842 | Formula: C18H16ClNO4S
  • H donors: 1 H acceptors: 4 LogP: 3.27 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: Clc1ccc(cc1)S(=O)(=O)C1(CC1)C(=O)Nc1cccc(c1)C(=O)C
  • InChi: 1S/C18H16ClNO4S/c1-12(21)13-3-2-4-15(11-13)20-17(22)18(9-10-18)25(23,24)16-7-5-14(19)6-8-16/h2-8,11H,9-10H2,1H3,(H,20,22)
  • InChiKey: OVMQBCPEKPKEOP-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N-(3-acetylphenyl)-1-(4-chlorophenyl)sulfonyl-cyclopropane-1-carboxamide
  • N-(3-acetylphenyl)-1-(4-chlorophenyl)sulfonyl-1-cyclopropanecarboxamide
  • 1-(4-chlorophenyl)sulfonyl-N-(3-ethanoylphenyl)cyclopropane-1-carboxamide
  • EU-0057693

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.0015 0.0036 0.0164
Brugia malayi Trypsin-like protease protein 5 0.0015 0.0036 0.0225
Onchocerca volvulus 0.0036 0.0305 0.3661
Leishmania major phosphoinositide-specific phospholipase C, putative 0.0019 0.0087 0.0951
Onchocerca volvulus Casein kinase II subunit beta homolog 0.0076 0.0816 1
Trypanosoma brucei Casein kinase II subunit beta, putative 0.0076 0.0816 1
Toxoplasma gondii microneme protein MIC4 0.0036 0.0305 0.0719
Toxoplasma gondii PAN domain-containing protein 0.0036 0.0305 0.0719
Onchocerca volvulus 0.0036 0.0305 0.3661
Trichomonas vaginalis hypothetical protein 0.0188 0.2256 1
Trichomonas vaginalis casein kinase II beta chain, putative 0.0022 0.013 0.0052
Trichomonas vaginalis casein kinase II beta chain, putative 0.0022 0.013 0.0052
Plasmodium falciparum cysteine repeat modular protein 1 0.0055 0.0555 0.2429
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0021 0.0119 0.0685
Brugia malayi PAN domain containing protein 0.0036 0.0305 0.1907
Plasmodium falciparum casein kinase II beta chain 0.0076 0.0816 0.3589
Leishmania major hypothetical protein, conserved 0.0055 0.0555 0.6767
Loa Loa (eye worm) hypothetical protein 0.0015 0.0036 0.0164
Onchocerca volvulus 0.0021 0.0119 0.1351
Brugia malayi AMP-binding enzyme family protein 0.0072 0.0773 0.4834
Brugia malayi Trypsin family protein 0.0015 0.0036 0.0225
Trypanosoma brucei acetyl-CoA synthetase, putative 0.0021 0.0119 0.1351
Toxoplasma gondii PAN domain-containing protein 0.0036 0.0305 0.0719
Loa Loa (eye worm) hypothetical protein 0.0014 0.0031 0.0132
Echinococcus granulosus enteropeptidase 0.0015 0.0036 0.0323
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0072 0.0773 0.3399
Loa Loa (eye worm) casein kinase II 0.0022 0.013 0.0755
Trypanosoma brucei phosphoinositide-specific phospholipase C 0.002 0.0101 0.113
Trichomonas vaginalis casein kinase II beta chain, putative 0.0022 0.013 0.0052
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0021 0.0119 0.1351
Mycobacterium ulcerans hypothetical protein 0.0015 0.0036 0.0116
Toxoplasma gondii ck2 beta subunit 0.0076 0.0816 0.1965
Mycobacterium tuberculosis NADH-dependent enoyl-[acyl-carrier-protein] reductase InhA (NADH-dependent enoyl-ACP reductase) 0.0188 0.2256 1
Brugia malayi Chymotrypsin-like protease CTRL-1 precursor 0.0015 0.0036 0.0225
Leishmania major phosphatidylinositol-specific phospholipase-like protein 0.0019 0.0087 0.0951
Loa Loa (eye worm) hypothetical protein 0.0072 0.0773 0.4802
Brugia malayi PAN domain containing protein 0.0036 0.0305 0.1907
Onchocerca volvulus 0.0015 0.0036 0.0323
Plasmodium vivax enoyl-acyl carrier protein reductase 0.0188 0.2256 1
Onchocerca volvulus 0.002 0.0101 0.113
Schistosoma mansoni cercarial elastase (S01 family) 0.0015 0.0036 0.0441
Toxoplasma gondii PAN domain-containing protein 0.0332 0.4112 1
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0021 0.0119 0.1351
Brugia malayi Trypsin family protein 0.0015 0.0036 0.0225
Schistosoma mansoni cercarial elastase (S01 family) 0.0015 0.0036 0.0441
Toxoplasma gondii PAN/Apple domain-containing protein 0.0036 0.0305 0.0719
Entamoeba histolytica casein kinase II regulatory subunit family protein 0.0076 0.0816 1
Onchocerca volvulus 0.0036 0.0305 0.3661
Brugia malayi PAN domain containing protein 0.0036 0.0305 0.1907
Trichomonas vaginalis casein kinase II beta chain, putative 0.0076 0.0816 0.3263
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0072 0.0773 0.3399
Mycobacterium tuberculosis Peptide synthetase MbtE (peptide synthase) 0.0021 0.0119 0.0485
Trichomonas vaginalis casein kinase II beta chain, putative 0.0022 0.013 0.0052
Trichomonas vaginalis casein kinase II beta chain, putative 0.0076 0.0816 0.3263
Entamoeba histolytica acyl-CoA synthetase, putative 0.0072 0.0773 0.947
Schistosoma mansoni hypothetical protein 0.0015 0.0036 0.0441
Loa Loa (eye worm) hypothetical protein 0.0072 0.0773 0.4802
Onchocerca volvulus 0.0036 0.0305 0.3661
Brugia malayi Trypsin family protein 0.0015 0.0036 0.0225
Brugia malayi PAN domain containing protein 0.0036 0.0305 0.1907
Onchocerca volvulus 0.002 0.0101 0.113
Brugia malayi AMP-binding enzyme family protein 0.0072 0.0773 0.4834
Trichomonas vaginalis casein kinase II beta chain, putative 0.0076 0.0816 0.3263
Onchocerca volvulus 0.0021 0.0119 0.1351
Brugia malayi Protein kinase domain containing protein 0.0055 0.0555 0.3472
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtE 0.0021 0.0119 0.0485
Echinococcus granulosus tissue type plasminogen activator 0.0055 0.0555 0.6767
Mycobacterium tuberculosis Probable medium chain fatty-acid-CoA ligase FadD14 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0021 0.0119 0.0485
Loa Loa (eye worm) PAN domain-containing protein 0.0036 0.0305 0.1856
Toxoplasma gondii microneme protein MIC17B 0.0036 0.0305 0.0719
Trypanosoma brucei long-chain-fatty-acid-CoA ligase, putative 0.0021 0.0119 0.1351
Echinococcus multilocularis transmembrane protease serine 3 0.0015 0.0036 0.0026
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0015 0.0036 0.0441
Toxoplasma gondii Acetyl-coenzyme A synthetase 2, putative 0.0021 0.0119 0.0265
Mycobacterium ulcerans acyl-CoA synthetase 0.0021 0.0119 0.0485
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0015 0.0036 0.0441
Schistosoma mansoni dihydropteridine reductase 0.0013 0.001 0.0121
Trypanosoma cruzi Casein kinase II subunit beta, putative 0.0076 0.0816 1
Echinococcus multilocularis Mastin 0.0015 0.0036 0.0026
Toxoplasma gondii microneme protein MIC17A 0.0036 0.0305 0.0719
Leishmania major 4-coumarate:coa ligase-like protein 0.0072 0.0773 0.947
Loa Loa (eye worm) hypothetical protein 0.0036 0.0305 0.1856
Mycobacterium ulcerans O-succinylbenzoic acid--CoA ligase 0.0021 0.0119 0.0485
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0021 0.0119 0.0485
Mycobacterium ulcerans acetyl-CoA synthetase 0.0021 0.0119 0.0485
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0054 0.0539 0.2356
Mycobacterium ulcerans acyl-CoA synthetase 0.0072 0.0773 0.3399
Schistosoma mansoni cercarial elastase (S01 family) 0.0015 0.0036 0.0441
Toxoplasma gondii calcium binding egf domain-containing protein 0.0014 0.0031 0.0051
Plasmodium falciparum enoyl-acyl carrier reductase 0.0188 0.2256 1
Mycobacterium leprae POSSIBLE O-SUCCINYLBENZOIC ACID--CoA LIGASE MENE (OSB-CoA SYNTHETASE) (O-SUCCINYLBENZOATE-CoA SYNTHASE) 0.0021 0.0119 0.0485
Loa Loa (eye worm) hypothetical protein 0.0021 0.0119 0.0685
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative 0.0021 0.0119 0.1351
Leishmania major protein kinase ck2 regulatory subunit, putative 0.0076 0.0816 1
Plasmodium vivax casein kinase II beta chain, putative 0.0076 0.0816 0.3589
Leishmania major acetyl-CoA synthetase, putative 0.0021 0.0119 0.1351
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0054 0.0539 0.2356
Loa Loa (eye worm) Csnk2b protein 0.0076 0.0816 0.5071
Mycobacterium ulcerans acyl-CoA synthetase 0.0021 0.0119 0.0485
Loa Loa (eye worm) trypsin family protein 0.0015 0.0036 0.0164
Leishmania major acetyl-CoA synthetase, putative 0.0021 0.0119 0.1351
Trichomonas vaginalis casein kinase II beta chain, putative 0.0076 0.0816 0.3263
Brugia malayi Csnk2b protein 0.0076 0.0816 0.5101
Trichomonas vaginalis casein kinase II beta chain, putative 0.0022 0.013 0.0052
Trichomonas vaginalis casein kinase II beta chain, putative 0.0022 0.013 0.0052
Onchocerca volvulus 0.0036 0.0305 0.3661
Schistosoma mansoni cercarial elastase (S01 family) 0.0015 0.0036 0.0441
Mycobacterium ulcerans acyl-CoA synthetase 0.0021 0.0119 0.0485
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0021 0.0119 0.1351
Trypanosoma cruzi phosphoinositide-specific phospholipase C, putative 0.002 0.0101 0.113
Loa Loa (eye worm) hypothetical protein 0.0036 0.0305 0.1856
Mycobacterium tuberculosis PROBABLE FATTY-ACID-CoA LIGASE FADD18 (FRAGMENT) (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0018 0.0081 0.0317
Echinococcus granulosus laminin 0.0014 0.0031 0.0261
Mycobacterium tuberculosis Peptide synthetase MbtF (peptide synthase) 0.0021 0.0119 0.0485
Loa Loa (eye worm) hypothetical protein 0.0036 0.0305 0.1856
Onchocerca volvulus 0.0015 0.0036 0.0323
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0072 0.0773 0.3399
Chlamydia trachomatis enoyl-acyl-carrier protein reductase 0.0188 0.2256 1
Brugia malayi Phosphatidylinositol-specific phospholipase C, X domain containing protein 0.002 0.0101 0.0631
Schistosoma mansoni 3-oxoacyl-[ACP] reductase 0.0013 0.001 0.0121
Onchocerca volvulus 0.0072 0.0773 0.947
Plasmodium falciparum acyl-CoA synthetase 0.0054 0.0539 0.2356
Onchocerca volvulus 0.0036 0.0305 0.3661
Brugia malayi AMP-binding enzyme family protein 0.0021 0.0119 0.0743
Onchocerca volvulus 0.0015 0.0036 0.0323
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0015 0.0036 0.0441
Trichomonas vaginalis casein kinase II beta chain, putative 0.0022 0.013 0.0052
Trichomonas vaginalis casein kinase II beta chain, putative 0.0022 0.013 0.0052
Brugia malayi Phosphatidylinositol-specific phospholipase C, X domain containing protein 0.0019 0.0087 0.0541
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 0.0021 0.0119 0.0485
Echinococcus granulosus transmembrane protease serine 3 0.0015 0.0036 0.0323
Schistosoma mansoni cercarial elastase (S01 family) 0.0015 0.0036 0.0441
Onchocerca volvulus 0.0036 0.0305 0.3661
Plasmodium vivax phospholipase C-like, putative 0.0019 0.0087 0.0341
Brugia malayi PAN domain containing protein 0.0036 0.0305 0.1907
Brugia malayi AMP-binding enzyme family protein 0.0021 0.0119 0.0743
Toxoplasma gondii kringle domain-containing protein 0.0055 0.0555 0.133
Onchocerca volvulus 0.0036 0.0305 0.3661
Loa Loa (eye worm) hypothetical protein 0.0036 0.0305 0.1856
Schistosoma mansoni egf-like domain protein 0.0014 0.0031 0.0379
Loa Loa (eye worm) hypothetical protein 0.0054 0.0539 0.3329
Onchocerca volvulus Casein kinase II subunit beta homolog 0.0076 0.0816 1
Brugia malayi Kringle domain containing protein 0.0055 0.0555 0.3472
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0072 0.0773 0.3399
Toxoplasma gondii calcium binding egf domain-containing protein 0.0014 0.0031 0.0051
Echinococcus multilocularis laminin 0.0014 0.0031 0.0021
Echinococcus granulosus acetyl coenzyme A synthetase cytoplasmic 0.0021 0.0119 0.1351
Mycobacterium ulcerans bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ACP synthetase 0.0021 0.0119 0.0485
Schistosoma mansoni casein kinase II beta subunit 0.0076 0.0816 1
Echinococcus granulosus casein kinase ii subunit beta 0.0076 0.0816 1
Schistosoma mansoni cercarial elastase (S01 family) 0.0015 0.0036 0.0441
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) 0.0021 0.0119 0.0485
Loa Loa (eye worm) hypothetical protein 0.0014 0.0031 0.0132
Giardia lamblia Casein kinase II beta chain 0.0076 0.0816 1
Mycobacterium ulcerans acyl-CoA synthetase 0.0021 0.0119 0.0485
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtF 0.0021 0.0119 0.0485
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0021 0.0119 0.0485
Trichomonas vaginalis protein kinase ck2-beta, putative 0.0022 0.013 0.0052
Brugia malayi PAN domain containing protein 0.0036 0.0305 0.1907
Entamoeba histolytica casein kinase II regulatory subunit family protein 0.0076 0.0816 1
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0072 0.0773 0.3399
Toxoplasma gondii subtilisin SUB12 0.0036 0.0305 0.0719
Wolbachia endosymbiont of Brugia malayi enoyl-ACP reductase 0.0188 0.2256 1
Toxoplasma gondii PAN domain-containing protein 0.0036 0.0305 0.0719
Echinococcus multilocularis acetyl coenzyme A synthetase, cytoplasmic 0.0021 0.0119 0.0109
Schistosoma mansoni subfamily M12A unassigned peptidase (M12 family) 0.0014 0.0031 0.0379
Loa Loa (eye worm) PAN domain-containing protein 0.0036 0.0305 0.1856
Trichomonas vaginalis casein kinase II beta chain, putative 0.0022 0.013 0.0052
Trichomonas vaginalis casein kinase II beta chain, putative 0.0076 0.0816 0.3263
Plasmodium vivax casein kinase II beta chain, putative 0.0076 0.0816 0.3589
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0051 0.0501 0.2188
Mycobacterium ulcerans hypothetical protein 0.0072 0.0773 0.3399
Schistosoma mansoni hypothetical protein 0.0015 0.0036 0.0441
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0054 0.0539 0.2356
Entamoeba histolytica casein kinase II regulatory subunit family protein 0.0076 0.0816 1
Trichomonas vaginalis casein kinase II beta chain, putative 0.0022 0.013 0.0052
Leishmania major long-chain-fatty-acid-CoA ligase, putative 0.0021 0.0119 0.1351
Schistosoma mansoni cercarial elastase (S01 family) 0.0015 0.0036 0.0441
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD22 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) 0.0021 0.0119 0.0485
Loa Loa (eye worm) hypothetical protein 0.0014 0.0031 0.0132
Trichomonas vaginalis casein kinase II beta chain, putative 0.0076 0.0816 0.3263
Schistosoma mansoni cercarial elastase (S01 family) 0.0015 0.0036 0.0441
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0072 0.0773 0.3399
Toxoplasma gondii hypothetical protein 0.0036 0.0305 0.0719
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0021 0.0119 0.1351
Echinococcus granulosus subfamily S1A unassigned peptidase S01 family 0.0015 0.0036 0.0323
Loa Loa (eye worm) hypothetical protein 0.0054 0.0539 0.3329
Loa Loa (eye worm) hypothetical protein 0.0019 0.0087 0.0482
Leishmania major 4-coumarate:coa ligase-like protein 0.0072 0.0773 0.947
Loa Loa (eye worm) hypothetical protein 0.0036 0.0305 0.1856
Echinococcus granulosus Mastin 0.0015 0.0036 0.0323
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0015 0.0036 0.0441
Leishmania major 4-coumarate:coa ligase-like protein 0.0072 0.0773 0.947
Loa Loa (eye worm) low-density lipoprotein receptor repeat class B containing protein 0.0014 0.0031 0.0132
Schistosoma mansoni cercarial elastase (S01 family) 0.0015 0.0036 0.0441
Toxoplasma gondii microneme protein, putative 0.0036 0.0305 0.0719
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0072 0.0773 0.3399
Echinococcus multilocularis subfamily S1A unassigned peptidase (S01 family) 0.0015 0.0036 0.0026
Loa Loa (eye worm) multiple epidermal growth factor-like domains 6 0.0014 0.0031 0.0132
Onchocerca volvulus 0.0036 0.0305 0.3661
Toxoplasma gondii AMP-binding enzyme domain-containing protein 0.0021 0.0119 0.0265
Entamoeba histolytica casein kinase II regulatory subunit family protein 0.0022 0.013 0.1489
Echinococcus granulosus 1-Phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta-4 0.002 0.0101 0.113
Schistosoma mansoni phospholipase C beta 0.0019 0.0087 0.1061
Echinococcus multilocularis enteropeptidase 0.0015 0.0036 0.0026
Plasmodium falciparum phosphoinositide-specific phospholipase C 0.0019 0.0087 0.0341
Plasmodium vivax cysteine repeat modular protein 1, putative 0.0055 0.0555 0.2429
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0072 0.0773 0.3399
Echinococcus multilocularis 1 phosphatidylinositol 4,5 bisphosphate 0.002 0.0101 0.0091
Entamoeba histolytica acyl-coA synthetase, putative 0.0072 0.0773 0.947
Echinococcus multilocularis fibrillin 1 0.0014 0.0031 0.0021
Echinococcus multilocularis tissue type plasminogen activator 0.0055 0.0555 0.0546
Mycobacterium ulcerans acyl-CoA synthetase 0.0072 0.0773 0.3399
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0021 0.0119 0.0485
Toxoplasma gondii phosphoinositide phospholipase PIPLC 0.002 0.0101 0.0222
Trypanosoma cruzi hypothetical protein, conserved 0.0055 0.0555 0.6767
Mycobacterium leprae NADH-DEPENDENT ENOYL-[ACYL-CARRIER-PROTEIN] REDUCTASE INHA (NADH-DEPENDENT ENOYL-ACP REDUCTASE) 0.0188 0.2256 1
Schistosoma mansoni cercarial elastase (S01 family) 0.0015 0.0036 0.0441
Loa Loa (eye worm) hypothetical protein 0.0054 0.0539 0.3329
Echinococcus granulosus glycoprotein Antigen 5 0.0015 0.0036 0.0323
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0021 0.0119 0.0685
Echinococcus multilocularis glycoprotein Antigen 5 0.0015 0.0036 0.0026
Loa Loa (eye worm) hypothetical protein 0.002 0.0101 0.0573
Toxoplasma gondii propionate-CoA ligase 0.0021 0.0119 0.0265
Onchocerca volvulus 0.0036 0.0305 0.3661
Loa Loa (eye worm) PAN domain-containing protein 0.0036 0.0305 0.1856
Loa Loa (eye worm) Plcb4 protein 0.0019 0.0087 0.0482
Mycobacterium ulcerans acyl-CoA synthetase 0.0021 0.0119 0.0485
Echinococcus multilocularis casein kinase ii subunit beta 0.0076 0.0816 0.0807
Brugia malayi hypothetical protein 0.0015 0.0036 0.0225
Leishmania major phospholipase c-like protein 0.002 0.0101 0.113
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0021 0.0119 0.0743
Trichomonas vaginalis casein kinase II beta chain, putative 0.0076 0.0816 0.3263
Plasmodium falciparum casein kinase II beta chain 0.0076 0.0816 0.3589
Toxoplasma gondii hypothetical protein 0.0036 0.0305 0.0719
Schistosoma mansoni hypothetical protein 0.0055 0.0555 0.6807
Loa Loa (eye worm) PAN domain-containing protein 0.0036 0.0305 0.1856
Brugia malayi PAN domain containing protein 0.0036 0.0305 0.1907
Mycobacterium tuberculosis Fatty-acid-CoA synthetase FadD17 (fatty-acid-CoA synthase) (fatty-acid-CoA ligase) 0.0021 0.0119 0.0485
Trichomonas vaginalis casein kinase II beta chain, putative 0.0076 0.0816 0.3263
Mycobacterium leprae POSSIBLE FATTY-ACID-CoA LIGASE FADD10 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0021 0.0119 0.0485
Trichomonas vaginalis casein kinase II beta chain, putative 0.0076 0.0816 0.3263
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase 0.0021 0.0119 0.0485
Onchocerca volvulus 0.0021 0.0119 0.1351
Brugia malayi PAN domain containing protein 0.0036 0.0305 0.1907
Loa Loa (eye worm) hypothetical protein 0.0036 0.0305 0.1856
Loa Loa (eye worm) hypothetical protein 0.0015 0.0036 0.0164
Plasmodium vivax acyl-CoA synthetase, putative 0.0054 0.0539 0.2356
Trichomonas vaginalis casein kinase II beta chain, putative 0.0022 0.013 0.0052
Loa Loa (eye worm) hypothetical protein 0.0054 0.0539 0.3329
Trichomonas vaginalis casein kinase II beta chain, putative 0.0076 0.0816 0.3263
Brugia malayi Calcium binding EGF domain containing protein 0.0014 0.0031 0.0193
Loa Loa (eye worm) bone morphogenetic protein 1b 0.0014 0.0031 0.0132
Brugia malayi AMP-binding enzyme family protein 0.0021 0.0119 0.0743
Mycobacterium ulcerans enoyl-(acyl carrier protein) reductase 0.0188 0.2256 1
Echinococcus granulosus Peptidase S1 S6 chymotrypsin Hap 0.0015 0.0036 0.0323
Loa Loa (eye worm) variant SH3 domain-containing protein 0.0137 0.16 1
Brugia malayi PAN domain containing protein 0.0036 0.0305 0.1907
Trichomonas vaginalis casein kinase II beta chain, putative 0.0022 0.013 0.0052
Brugia malayi PAN domain containing protein 0.0036 0.0305 0.1907
Loa Loa (eye worm) hypothetical protein 0.0021 0.0119 0.0685
Onchocerca volvulus 0.0015 0.0036 0.0323
Plasmodium vivax acetyl-CoA synthetase, putative 0.0021 0.0119 0.0485
Trichomonas vaginalis casein kinase II beta chain, putative 0.0076 0.0816 0.3263
Onchocerca volvulus 0.0015 0.0036 0.0323
Echinococcus multilocularis Peptidase S1 S6, chymotrypsin Hap 0.0015 0.0036 0.0026
Loa Loa (eye worm) hypothetical protein 0.0055 0.0555 0.3431
Onchocerca volvulus 0.0021 0.0119 0.1351
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD10 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0021 0.0119 0.0485
Toxoplasma gondii casein kinase ii regulatory subunit protein 0.0076 0.0816 0.1965
Onchocerca volvulus Arrow homolog 0.0014 0.0031 0.0261
Trichomonas vaginalis casein kinase II beta chain, putative 0.0076 0.0816 0.3263
Brugia malayi casein kinase II, putaitve 0.0022 0.013 0.0812
Trichomonas vaginalis casein kinase II beta chain, putative 0.0076 0.0816 0.3263
Loa Loa (eye worm) hypothetical protein 0.0054 0.0539 0.3329
Toxoplasma gondii microneme protein MIC17C 0.0036 0.0305 0.0719
Loa Loa (eye worm) hypothetical protein 0.0072 0.0773 0.4802
Mycobacterium ulcerans peptide synthetase Nrp (peptide synthase) 0.0021 0.0119 0.0485
Trichomonas vaginalis casein kinase II beta chain, putative 0.0076 0.0816 0.3263
Loa Loa (eye worm) PAN domain-containing protein 0.0036 0.0305 0.1856
Loa Loa (eye worm) hypothetical protein 0.0014 0.0031 0.0132
Echinococcus granulosus Tolloid protein 1 0.0014 0.0031 0.0261
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0051 0.0501 0.2188
Mycobacterium ulcerans phenyloxazoline synthase MbtB 0.0021 0.0119 0.0485
Loa Loa (eye worm) TK/ROR protein kinase 0.0055 0.0555 0.3431
Trypanosoma cruzi Casein kinase II subunit beta, putative 0.0076 0.0816 1
Brugia malayi Fibulin-1 precursor 0.0014 0.0031 0.0193
Brugia malayi 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta 4 0.0019 0.0087 0.0541
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD1 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0021 0.0119 0.0485
Onchocerca volvulus 0.0015 0.0036 0.0323
Brugia malayi AMP-binding enzyme family protein 0.0072 0.0773 0.4834
Toxoplasma gondii 1,3(4)-beta-glucanase 0.0036 0.0305 0.0719
Mycobacterium ulcerans acyl-CoA synthetase 0.0021 0.0119 0.0485
Trichomonas vaginalis casein kinase II beta chain, putative 0.0076 0.0816 0.3263
Entamoeba histolytica casein kinase II regulatory subunit family protein 0.0022 0.013 0.1489
Brugia malayi Trypsin family protein 0.0015 0.0036 0.0225
Loa Loa (eye worm) hypothetical protein 0.0015 0.0036 0.0164
Toxoplasma gondii PAN domain-containing protein 0.0332 0.4112 1
Onchocerca volvulus 0.0036 0.0305 0.3661
Toxoplasma gondii PAN domain-containing protein 0.0036 0.0305 0.0719
Loa Loa (eye worm) hypothetical protein 0.002 0.0101 0.0573
Mycobacterium ulcerans acyl-CoA synthetase 0.0072 0.0773 0.3399
Loa Loa (eye worm) hypothetical protein 0.0015 0.0036 0.0164
Brugia malayi Variant SH3 domain containing protein 0.0137 0.16 1
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0013 0.001 0.0062
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0051 0.0501 0.2188
Echinococcus multilocularis Tolloid protein 1 0.0014 0.0031 0.0021
Mycobacterium ulcerans long-chain-acyl-CoA synthetase 0.0021 0.0119 0.0485
Loa Loa (eye worm) phosphatidylinositol-specific phospholipase C 0.002 0.0101 0.0573
Loa Loa (eye worm) hypothetical protein 0.0015 0.0036 0.0164
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0013 0.001 0.0062
Schistosoma mansoni cercarial elastase (S01 family) 0.0015 0.0036 0.0441
Schistosoma mansoni acetyl-CoA synthetase 0.0021 0.0119 0.1456
Brugia malayi AMP-binding enzyme family protein 0.0021 0.0119 0.0743
Loa Loa (eye worm) hypothetical protein 0.0036 0.0305 0.1856
Plasmodium falciparum acetyl-CoA synthetase, putative 0.0021 0.0119 0.0485
Schistosoma mansoni aminopeptidase PILS (M01 family) 0.0015 0.0036 0.0441
Brugia malayi Low-density lipoprotein receptor repeat class B containing protein 0.0014 0.0031 0.0193
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0015 0.0036 0.0441
Trichomonas vaginalis casein kinase II beta chain, putative 0.0022 0.013 0.0052
Loa Loa (eye worm) hypothetical protein 0.0014 0.0031 0.0132
Brugia malayi acetyl-Coenzyme A synthetase 2 0.0021 0.0119 0.0743
Loa Loa (eye worm) oxidoreductase 0.0021 0.0119 0.0685
Onchocerca volvulus 0.0055 0.0555 0.6767
Mycobacterium ulcerans acyl-CoA synthetase 0.0021 0.0119 0.0485
Mycobacterium ulcerans acyl-CoA synthetase 0.0021 0.0119 0.0485
Entamoeba histolytica acyl-CoA synthetase, putative 0.0072 0.0773 0.947
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0015 0.0036 0.0441
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0051 0.0501 0.2188
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0015 0.0036 0.0441
Loa Loa (eye worm) hypothetical protein 0.0015 0.0036 0.0164
Trichomonas vaginalis protein kinase ck2-beta, putative 0.0022 0.013 0.0052
Toxoplasma gondii enoyl-acyl carrier reductase ENR 0.0188 0.2256 0.5476

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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