Detailed information for compound 796213

Basic information

Technical information
  • TDR Targets ID: 796213
  • Name: 2-(5-bromo-6-nitro-1,3-dioxoisoindol-2-yl)ace tic acid
  • MW: 329.06 | Formula: C10H5BrN2O6
  • H donors: 1 H acceptors: 6 LogP: 1.01 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: OC(=O)CN1C(=O)c2c(C1=O)cc(c(c2)Br)[N+](=O)[O-]
  • InChi: 1S/C10H5BrN2O6/c11-6-1-4-5(2-7(6)13(18)19)10(17)12(9(4)16)3-8(14)15/h1-2H,3H2,(H,14,15)
  • InChiKey: OONXJWMFLGYWJJ-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 2-(5-bromo-6-nitro-1,3-dioxo-isoindolin-2-yl)acetic acid
  • 2-(5-bromo-6-nitro-1,3-dioxo-2-isoindolinyl)acetic acid
  • 2-(5-bromo-1,3-diketo-6-nitro-isoindolin-2-yl)acetic acid
  • 2-(5-bromo-6-nitro-1,3-dioxo-isoindol-2-yl)ethanoic acid
  • Oprea1_392196

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0033 0.0045 0.0039
Echinococcus granulosus lamin dm0 0.0029 0.0037 0.0036
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0076 0.0148 1
Schistosoma mansoni microtubule-associated protein tau 0.4239 1 1
Loa Loa (eye worm) MH2 domain-containing protein 0.0131 0.0278 0.2597
Loa Loa (eye worm) latrophilin receptor protein 2 0.0016 0.0005 0.005
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) 0.0076 0.0148 0.0291
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0028 0.0753
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0345 0.0785 0.1638
Loa Loa (eye worm) hypothetical protein 0.0034 0.0049 0.0458
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.003 0.0413
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.0054 0.0827
Mycobacterium tuberculosis Transcriptional regulatory repressor protein (TetR-family) EthR 0.2016 0.474 1
Schistosoma mansoni tar DNA-binding protein 0.0064 0.0119 0.0114
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.003 0.0415
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0047 0.0079 0.2569
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0345 0.0785 0.1635
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0136 0.029 0.0592
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0016 0.0005 0.0004
Echinococcus multilocularis peptidase Clp (S14 family) 0.005 0.0086 0.0085
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0311 0.0703 0.1462
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0049 0.0084 0.0082
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0049 0.0084 0.0078
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.0127 0.0269 0.0267
Schistosoma mansoni transcription factor LCR-F1 0.011 0.0229 0.0223
Plasmodium vivax SET domain protein, putative 0.0033 0.0045 0.064
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0016 0.0005 0.0004
Entamoeba histolytica hypothetical protein 0.011 0.0229 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0039 0.006 0.0932
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0049 0.0084 0.2719
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0047 0.0079 0.2569
Brugia malayi Calcitonin receptor-like protein seb-1 0.005 0.0087 0.0767
Schistosoma mansoni lamin 0.0029 0.0037 0.0032
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.003 0.0415
Loa Loa (eye worm) RNA binding protein 0.0064 0.0119 0.111
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.003 0.0413
Loa Loa (eye worm) TAR-binding protein 0.0064 0.0119 0.111
Mycobacterium leprae Probable transcriptional regulatory repressor protein (TetR-family) EthR 0.202 0.4749 1
Echinococcus multilocularis lamin 0.0029 0.0037 0.0036
Schistosoma mansoni thyroid hormone receptor 0.0137 0.0293 0.0287
Entamoeba histolytica hypothetical protein 0.011 0.0229 1
Echinococcus granulosus thioredoxin glutathione reductase 0.0137 0.0291 0.029
Leishmania major trypanothione reductase 0.0136 0.029 1
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0026 0.003 0.0071
Onchocerca volvulus 0.0095 0.0193 0.2876
Loa Loa (eye worm) hypothetical protein 0.0029 0.0036 0.0336
Plasmodium vivax thioredoxin reductase, putative 0.0136 0.029 1
Echinococcus granulosus survival motor neuron protein 1 0.0467 0.1072 0.1071
Echinococcus multilocularis thioredoxin glutathione reductase 0.0137 0.0291 0.029
Loa Loa (eye worm) phosphatidylinositol 3 0.0049 0.0084 0.078
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0064 0.0119 0.111
Schistosoma mansoni tar DNA-binding protein 0.0064 0.0119 0.0114
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0047 0.0079 0.2569
Plasmodium falciparum glutathione reductase 0.0047 0.0079 0.1963
Entamoeba histolytica hypothetical protein 0.011 0.0229 1
Brugia malayi RNA binding protein 0.0064 0.0119 0.1069
Echinococcus multilocularis lamin dm0 0.0029 0.0037 0.0036
Brugia malayi Intermediate filament tail domain containing protein 0.0029 0.0037 0.0303
Trypanosoma cruzi trypanothione reductase, putative 0.0136 0.029 1
Treponema pallidum NADH oxidase 0.0047 0.0079 0.5028
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0033 0.0045 0.0043
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0033 0.0045 0.0039
Trichomonas vaginalis mercuric reductase, putative 0.0047 0.0079 0.1272
Brugia malayi Probable ClpP-like protease 0.0076 0.0148 0.134
Echinococcus multilocularis microtubule associated protein 2 0.4239 1 1
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0047 0.0079 0.1963
Mycobacterium leprae ATP-dependent Clp protease proteolytic subunit 1 0.0026 0.003 0.0042
Trypanosoma brucei trypanothione reductase 0.0136 0.029 1
Echinococcus granulosus intermediate filament protein 0.0029 0.0037 0.0036
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.0016 0.0007 0.0005
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.003 0.0415
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0047 0.0079 0.2569
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0047 0.0079 0.1963
Echinococcus multilocularis ferritin 0.0018 0.001 0.0009
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.0016 0.0007 0.0005
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0311 0.0703 0.1465
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0047 0.0079 0.1963
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) 0.005 0.0086 0.016
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0016 0.0005 0.0004
Trichomonas vaginalis PIKK family atypical protein kinase 0.0049 0.0084 0.1347
Loa Loa (eye worm) pigment dispersing factor receptor c 0.005 0.0087 0.081
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0033 0.0045 0.0039
Schistosoma mansoni apoferritin-2 0.0018 0.001 0.0005
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.0045 0.068
Trichomonas vaginalis PIKK family atypical protein kinase 0.0029 0.0037 0.0531
Trichomonas vaginalis glutathione reductase, putative 0.0047 0.0079 0.1272
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0047 0.0079 0.2569
Brugia malayi Pre-SET motif family protein 0.0227 0.0505 0.4681
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0016 0.0005 0.0004
Echinococcus granulosus GPCR family 2 0.0016 0.0005 0.0004
Schistosoma mansoni tar DNA-binding protein 0.0064 0.0119 0.0114
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0026 0.003 0.0071
Echinococcus granulosus tumor protein p63 0.1006 0.2348 0.2347
Brugia malayi Thioredoxin reductase 0.0136 0.029 0.267
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0028 0.0753
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0035 0.005 0.0419
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0049 0.0084 0.2719
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.0054 0.0827
Schistosoma mansoni ferritin light chain 0.0018 0.001 0.0005
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0039 0.006 0.1885
Loa Loa (eye worm) intermediate filament protein 0.0029 0.0037 0.0348
Brugia malayi Pre-SET motif family protein 0.0033 0.0045 0.0372
Schistosoma mansoni ferritin light chain 0.0018 0.001 0.0005
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.0054 0.0827
Brugia malayi hypothetical protein 0.011 0.0229 0.2095
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0311 0.0703 0.1465
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0047 0.0079 0.0074
Brugia malayi TAR-binding protein 0.0064 0.0119 0.1069
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.002 0.0016 0.0327
Schistosoma mansoni apoferritin-2 0.0018 0.001 0.0005
Trichomonas vaginalis PIKK family atypical protein kinase 0.0029 0.0036 0.0519
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0076 0.0148 0.458
Schistosoma mansoni ferritin 0.0018 0.001 0.0005
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0076 0.0148 0.0291
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0047 0.0079 0.2569
Brugia malayi glutathione reductase 0.0136 0.029 0.267
Toxoplasma gondii target of rapamycin (TOR), putative 0.0036 0.0054 0.0992
Wolbachia endosymbiont of Brugia malayi ATP-dependent Clp protease proteolytic subunit 0.0076 0.0148 1
Echinococcus granulosus tar DNA binding protein 0.0064 0.0119 0.0118
Mycobacterium tuberculosis Probable oxidoreductase 0.0345 0.0785 0.1638
Echinococcus multilocularis tumor protein p63 0.1006 0.2348 0.2347
Echinococcus multilocularis tar DNA binding protein 0.0064 0.0119 0.0118
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.0054 0.0827
Echinococcus granulosus peptidase Clp S14 family 0.005 0.0086 0.0085
Schistosoma mansoni lamin 0.0029 0.0037 0.0032
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0047 0.0079 0.2569
Plasmodium falciparum thioredoxin reductase 0.0136 0.029 1
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0049 0.0084 0.2719
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0311 0.0703 0.1465
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0033 0.0045 0.0043
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.0023 0.0023 0.0563
Loa Loa (eye worm) thioredoxin reductase 0.0136 0.029 0.2704
Schistosoma mansoni intermediate filament proteins 0.0029 0.0037 0.0032
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0033 0.0045 0.064
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0047 0.0079 0.0078
Schistosoma mansoni hypothetical protein 0.0034 0.0049 0.0044
Trichomonas vaginalis PIKK family atypical protein kinase 0.0049 0.0084 0.1347
Toxoplasma gondii hypothetical protein 0.0026 0.003 0.0071
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0076 0.0148 0.458
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) 0.005 0.0086 0.016
Loa Loa (eye worm) glutathione reductase 0.0136 0.029 0.2704
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0047 0.0079 0.0146
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0311 0.0703 0.1465
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0076 0.0148 1
Plasmodium falciparum thioredoxin reductase 0.0047 0.0079 0.1963
Loa Loa (eye worm) hypothetical protein 0.0467 0.1072 1
Schistosoma mansoni thyroid hormone receptor 0.0137 0.0293 0.0287
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.0127 0.0269 0.0267
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0076 0.0148 0.458
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0076 0.0148 0.458
Loa Loa (eye worm) transcription factor SMAD2 0.0131 0.0278 0.2597
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0016 0.0005 0.0046
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0049 0.0084 0.2719
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.0054 0.0827
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0047 0.0079 0.1963
Schistosoma mansoni tar DNA-binding protein 0.0064 0.0119 0.0114
Echinococcus granulosus expressed protein 0.0018 0.001 0.0009
Brugia malayi hypothetical protein 0.0025 0.0028 0.0215
Toxoplasma gondii thioredoxin reductase 0.0136 0.029 1
Schistosoma mansoni peptidase Clp (S14 family) 0.0076 0.0148 0.0143
Echinococcus multilocularis ATP dependent Clp protease proteolytic subunit 0.0076 0.0148 0.0147
Trichomonas vaginalis PIKK family atypical protein kinase 0.0032 0.0043 0.0636
Trichomonas vaginalis PIKK family atypical protein kinase 0.0049 0.0084 0.1347
Trypanosoma brucei PAB1-binding protein , putative 0.0025 0.0028 0.0753
Loa Loa (eye worm) hypothetical protein 0.0025 0.0028 0.026
Onchocerca volvulus 0.0033 0.0045 0.0137
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0047 0.0079 0.2569
Loa Loa (eye worm) hypothetical protein 0.0033 0.0045 0.0417
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0076 0.0148 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.0054 0.0827
Schistosoma mansoni ferritin 0.0018 0.001 0.0005
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0033 0.0045 0.0039
Trichomonas vaginalis PIKK family atypical protein kinase 0.0039 0.006 0.0932
Echinococcus multilocularis GPCR, family 2 0.0016 0.0005 0.0004
Trichomonas vaginalis PIKK family atypical protein kinase 0.0029 0.0037 0.0531
Schistosoma mansoni ferritin 0.0018 0.001 0.0005
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) 0.005 0.0086 0.016
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0047 0.0079 0.0146
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0016 0.0007 0.0015
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0049 0.0084 0.0737
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0035 0.005 0.0419
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.0016 0.0007 0.0001
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0049 0.0084 0.0082
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0016 0.0005 0.0004
Mycobacterium ulcerans transcriptional regulator 0.202 0.4749 1
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0076 0.0148 0.0291
Echinococcus granulosus histone lysine methyltransferase setb 0.0033 0.0045 0.0043
Trichomonas vaginalis PIKK family atypical protein kinase 0.0039 0.006 0.0932
Trichomonas vaginalis PIKK family atypical protein kinase 0.0039 0.006 0.0932
Leishmania major hypothetical protein, conserved 0.0025 0.0028 0.0753
Loa Loa (eye worm) hypothetical protein 0.0147 0.0316 0.2948
Brugia malayi hypothetical protein 0.0467 0.1072 1
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0047 0.0079 0.2569
Echinococcus granulosus ferritin 0.0018 0.001 0.0009
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0029 0.0037 0.0348
Entamoeba histolytica hypothetical protein 0.011 0.0229 1
Loa Loa (eye worm) hypothetical protein 0.005 0.0087 0.081
Schistosoma mansoni hypothetical protein 0.011 0.0229 0.0223
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0047 0.0079 0.5028
Trichomonas vaginalis PIKK family atypical protein kinase 0.0039 0.006 0.0932
Onchocerca volvulus 0.0147 0.0316 0.515
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0039 0.006 0.1885
Trypanosoma cruzi target of rapamycin kinase 3 0.0039 0.006 0.1885
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0047 0.0079 0.2569
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0047 0.0079 0.1963
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0047 0.0079 0.0146
Brugia malayi RNA recognition motif domain containing protein 0.0064 0.0119 0.1069
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0031 0.0042 0.0041
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.003 0.0413
Mycobacterium ulcerans AcrR family transcriptional regulator 0.202 0.4749 1
Mycobacterium ulcerans TetR family transcriptional regulator 0.202 0.4749 1
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0026 0.003 0.1434
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0047 0.0079 0.2569
Echinococcus multilocularis survival motor neuron protein 1 0.0467 0.1072 0.1071
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0047 0.0079 0.0078
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0047 0.0079 0.2569
Giardia lamblia GTOR 0.0049 0.0084 1
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.011 0.0229 0.0227
Echinococcus multilocularis thyroid hormone receptor alpha 0.0137 0.0293 0.0291
Trichomonas vaginalis set domain proteins, putative 0.0258 0.0579 1
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0047 0.0079 0.2569
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.0054 0.0827
Echinococcus multilocularis musashi 0.0029 0.0037 0.0036
Loa Loa (eye worm) hypothetical protein 0.0029 0.0037 0.0348
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0049 0.0084 0.2719
Mycobacterium tuberculosis Probable dehydrogenase 0.0311 0.0703 0.1465
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0049 0.0084 0.2719
Schistosoma mansoni survival motor neuron protein 0.0095 0.0193 0.0188
Mycobacterium tuberculosis Probable reductase 0.0311 0.0703 0.1465
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.005 0.0087 0.0767
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.011 0.0229 0.0227
Schistosoma mansoni ferritin 0.0018 0.001 0.0005
Plasmodium vivax glutathione reductase, putative 0.0136 0.029 1
Brugia malayi Latrophilin receptor protein 2 0.0016 0.0005 0.0004
Brugia malayi latrophilin 2 splice variant baaae 0.0034 0.0049 0.0414
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0047 0.0079 0.0147
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0345 0.0785 0.1638
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0047 0.0079 0.2569
Trichomonas vaginalis ferritin, putative 0.0018 0.001 0.006
Trichomonas vaginalis PIKK family atypical protein kinase 0.0029 0.0037 0.0531
Loa Loa (eye worm) hypothetical protein 0.0076 0.0148 0.138
Trypanosoma cruzi trypanothione reductase, putative 0.0047 0.0079 0.2569
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0047 0.0079 0.2569
Schistosoma mansoni hypothetical protein 0.0095 0.0193 0.0188
Onchocerca volvulus 0.0258 0.0579 1
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0227 0.0505 0.4706
Echinococcus multilocularis expressed protein 0.0018 0.001 0.0009
Echinococcus granulosus ATP dependent Clp protease proteolytic subunit 0.0076 0.0148 0.0147
Schistosoma mansoni hypothetical protein 0.0127 0.0269 0.0263
Brugia malayi MH2 domain containing protein 0.0131 0.0278 0.2562
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0047 0.0079 0.2569
Brugia malayi hypothetical protein 0.0016 0.0007 0.0015
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0047 0.0079 0.5028
Schistosoma mansoni cellular tumor antigen P53 0.0147 0.0316 0.0311
Plasmodium falciparum glutathione reductase 0.0136 0.029 1
Loa Loa (eye worm) phosphatidylinositol 3 0.0016 0.0007 0.0061
Trichomonas vaginalis PIKK family atypical protein kinase 0.0042 0.0067 0.105
Trichomonas vaginalis PIKK family atypical protein kinase 0.0029 0.0036 0.0519
Schistosoma mansoni tar DNA-binding protein 0.0064 0.0119 0.0114
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0047 0.0079 0.0697
Toxoplasma gondii NADPH-glutathione reductase 0.0047 0.0079 0.1963
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.003 0.0415
Loa Loa (eye worm) hypothetical protein 0.0016 0.0005 0.005
Loa Loa (eye worm) hypothetical protein 0.0014 0.0001 0.0012
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0095 0.0193 0.1762
Echinococcus granulosus lamin 0.0029 0.0037 0.0036
Brugia malayi intermediate filament protein 0.0029 0.0037 0.0303

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.