Detailed information for compound 797040

Basic information

Technical information
  • TDR Targets ID: 797040
  • Name: N-methyl-N-(3-methylphenyl)-3-[(1-propanoyl-2 ,3-dihydroindol-5-yl)sulfonyl]propanamide
  • MW: 414.518 | Formula: C22H26N2O4S
  • H donors: 0 H acceptors: 4 LogP: 2.38 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCC(=O)N1CCc2c1ccc(c2)S(=O)(=O)CCC(=O)N(c1cccc(c1)C)C
  • InChi: 1S/C22H26N2O4S/c1-4-21(25)24-12-10-17-15-19(8-9-20(17)24)29(27,28)13-11-22(26)23(3)18-7-5-6-16(2)14-18/h5-9,14-15H,4,10-13H2,1-3H3
  • InChiKey: PQCAISOESWDYKL-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N-methyl-N-(3-methylphenyl)-3-(1-propanoylindolin-5-yl)sulfonyl-propanamide
  • N-methyl-N-(3-methylphenyl)-3-[[1-(1-oxopropyl)-5-indolinyl]sulfonyl]propanamide
  • N-methyl-N-(3-methylphenyl)-3-(1-propionylindolin-5-yl)sulfonyl-propionamide

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus fmrfamide receptor 0.0056 0.0067 0.0113
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0056 0.0067 0.0113
Echinococcus multilocularis metabotropic glutamate receptor 5 0.0215 0.0286 0.0483
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0056 0.0067 0.0135
Echinococcus granulosus glutamate receptor ionotropic kainate 0.0419 0.0567 0.0958
Loa Loa (eye worm) isocitrate dehydrogenase 0.0018 0.0015 0.027
Toxoplasma gondii eukaryotic initiation factor 2B epsilon subunit, putative 0.0035 0.0038 0.0134
Brugia malayi hypothetical protein 0.0056 0.0067 0.1133
Echinococcus granulosus mannose 1 phosphate guanyltransferase beta 0.0036 0.004 0.0067
Loa Loa (eye worm) hypothetical protein 0.0029 0.003 0.0531
Brugia malayi RE15519p 0.0056 0.0067 0.1133
Schistosoma mansoni neuropeptide receptor 0.0056 0.0067 0.0135
Echinococcus granulosus metabotropic glutamate receptor 2 0.0215 0.0286 0.0483
Loa Loa (eye worm) hypothetical protein 0.0056 0.0067 0.1184
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0056 0.0067 0.0135
Brugia malayi follicle stimulating hormone receptor 0.0056 0.0067 0.1133
Loa Loa (eye worm) hypothetical protein 0.0056 0.0067 0.1184
Giardia lamblia Translation initiation factor 0.0035 0.0038 0.5
Loa Loa (eye worm) hypothetical protein 0.0056 0.0067 0.1184
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0018 0.0015 0.0026
Leishmania major hypothetical protein, conserved 0.0035 0.0038 0.0848
Echinococcus multilocularis dnaJ subfamily B 0.032 0.0431 0.0728
Echinococcus multilocularis dynactin 5 p25 0.0035 0.0038 0.0065
Onchocerca volvulus 0.0056 0.0067 0.1029
Loa Loa (eye worm) hypothetical protein 0.0056 0.0067 0.1184
Loa Loa (eye worm) melatonin receptor type 1A 0.0056 0.0067 0.1184
Echinococcus granulosus g protein coupled receptor 0.0056 0.0067 0.0113
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0056 0.0067 0.1029
Brugia malayi Metabotropic glutamate receptor precursor. 0.0215 0.0286 0.5016
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0018 0.0015 0.0025
Loa Loa (eye worm) hypothetical protein 0.0056 0.0067 0.1184
Echinococcus multilocularis g protein coupled receptor 0.0056 0.0067 0.0113
Echinococcus multilocularis NMDA receptor 0.0419 0.0567 0.0958
Loa Loa (eye worm) hypothetical protein 0.0018 0.0015 0.0269
Loa Loa (eye worm) hypothetical protein 0.0056 0.0067 0.1184
Echinococcus granulosus rhodopsin orphan GPCR 0.0056 0.0067 0.0113
Onchocerca volvulus 0.0056 0.0067 0.1029
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0056 0.0067 0.0135
Echinococcus multilocularis Ribosomal protein S1, RNA binding domain 0.0419 0.0567 0.0958
Plasmodium falciparum mannose-1-phosphate guanyltransferase, putative 0.0036 0.004 1
Echinococcus multilocularis orexin receptor type 2 0.0056 0.0067 0.0113
Loa Loa (eye worm) glutamate receptor 1 0.0419 0.0567 1
Echinococcus granulosus neuropeptide receptor A26 0.0056 0.0067 0.0113
Brugia malayi hypothetical protein 0.0345 0.0466 0.8211
Schistosoma mansoni biogenic amine (5HT) receptor 0.0056 0.0067 0.0135
Echinococcus multilocularis mannose 1 phosphate guanyltransferase beta 0.0035 0.0038 0.0065
Echinococcus granulosus rhodopsin orphan GPCR 0.0056 0.0067 0.0113
Echinococcus multilocularis mannose 1 phosphate guanyltransferase 0.0036 0.004 0.0067
Echinococcus granulosus g-protein coupled receptor 0.0056 0.0067 0.0113
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0056 0.0067 0.0135
Brugia malayi hypothetical protein 0.0035 0.0038 0.0621
Schistosoma mansoni gdp-mannose pyrophosphorylase b isoform 2 0.0036 0.004 0.0077
Echinococcus multilocularis metabotropic glutamate receptor 2 0.0215 0.0286 0.0483
Onchocerca volvulus 0.0056 0.0067 0.1029
Mycobacterium tuberculosis Conserved hypothetical protein 0.1262 0.1729 0.1716
Mycobacterium ulcerans molybdopterin-guanine dinucleotide biosynthesis protein A 0.1262 0.1729 0.1697
Loa Loa (eye worm) hypothetical protein 0.0056 0.0067 0.1184
Echinococcus granulosus G protein coupled receptor 139 0.0056 0.0067 0.0113
Brugia malayi Latrophilin receptor protein 2 0.0018 0.0015 0.0213
Brugia malayi G protein-coupled receptor 0.0056 0.0067 0.1133
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0056 0.0067 0.0113
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0056 0.0067 0.0113
Entamoeba histolytica translation initiation factor eIF-2B epsilon subunit, putative 0.0036 0.004 0.0063
Echinococcus multilocularis neuropeptide receptor 0.0056 0.0067 0.0113
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0056 0.0067 0.1133
Onchocerca volvulus 0.0056 0.0067 0.1029
Onchocerca volvulus 0.0056 0.0067 0.1029
Trypanosoma brucei PAB1-binding protein , putative 0.0029 0.003 0.604
Toxoplasma gondii histone lysine methyltransferase SET1 0.0043 0.0049 0.0197
Loa Loa (eye worm) hypothetical protein 0.0056 0.0067 0.1184
Loa Loa (eye worm) hypothetical protein 0.0056 0.0067 0.1184
Mycobacterium ulcerans hypothetical protein 0.1262 0.1729 0.1697
Echinococcus granulosus TGF beta signal transducer SmadC 0.0009 0.0003 0.0005
Schistosoma mansoni hypothetical protein 0.0018 0.0015 0.0025
Echinococcus granulosus glutamate receptor 2 0.0215 0.0286 0.0483
Onchocerca volvulus 0.0056 0.0067 0.1029
Echinococcus multilocularis rhodopsin orphan GPCR 0.0056 0.0067 0.0113
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0018 0.0015 0.0026
Mycobacterium ulcerans hypothetical protein 0.1262 0.1729 0.1697
Echinococcus multilocularis glutamate receptor subunit protein glur 0.0419 0.0567 0.0958
Loa Loa (eye worm) glutamate receptor 0.0215 0.0286 0.5044
Brugia malayi GDP-mannose pyrophosphorylase B 0.0036 0.004 0.0649
Loa Loa (eye worm) hypothetical protein 0.0056 0.0067 0.1184
Echinococcus multilocularis glutamate receptor, ionotrophic, AMPA 3 0.0633 0.0863 0.1457
Schistosoma mansoni amine GPCR 0.0056 0.0067 0.0135
Onchocerca volvulus 0.0056 0.0067 0.1029
Trypanosoma brucei nucleotidyl transferase, putative 0.0036 0.004 1
Onchocerca volvulus 0.0056 0.0067 0.1029
Brugia malayi Guanylyl cyclase protein 23 0.0215 0.0286 0.5016
Schistosoma mansoni hypothetical protein 0.0018 0.0015 0.0025
Echinococcus granulosus neuropeptide s receptor 0.0056 0.0067 0.0113
Schistosoma mansoni hypothetical protein 0.032 0.0431 0.0903
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0018 0.0015 0.0026
Echinococcus granulosus smad 0.0009 0.0003 0.0005
Loa Loa (eye worm) hypothetical protein 0.0035 0.0038 0.0675
Echinococcus multilocularis cpg binding protein 0.0024 0.0023 0.0039
Onchocerca volvulus 0.0056 0.0067 0.1029
Echinococcus granulosus sex peptide receptor 0.0056 0.0067 0.0113
Echinococcus multilocularis g-protein coupled receptor 0.0056 0.0067 0.0113
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0056 0.0067 0.0113
Echinococcus multilocularis nmda type glutamate receptor 0.4304 0.5919 1
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0633 0.0863 0.1457
Schistosoma mansoni amine GPCR 0.0056 0.0067 0.0135
Echinococcus granulosus tachykinin peptides receptor 99D 0.0056 0.0067 0.0113
Loa Loa (eye worm) hypothetical protein 0.0056 0.0067 0.1184
Brugia malayi putative neuropeptide receptor NPR1 0.0056 0.0067 0.1133
Loa Loa (eye worm) nucleotidyl transferase 0.0036 0.004 0.0702
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0056 0.0067 0.1133
Schistosoma mansoni neuropeptide receptor 0.0056 0.0067 0.0135
Brugia malayi hypothetical protein 0.0056 0.0067 0.1133
Loa Loa (eye worm) hypothetical protein 0.0057 0.0069 0.1215
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0038 0.0848
Schistosoma mansoni metabotropic glutamate receptor 0.0215 0.0286 0.0597
Schistosoma mansoni glutamate receptor kainate 0.0419 0.0567 0.1191
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0013 0.0008 0.0014
Echinococcus multilocularis smad 0.0009 0.0003 0.0005
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0633 0.0863 0.1457
Echinococcus granulosus tyrosine kinase 0.0215 0.0286 0.0483
Schistosoma mansoni mannose-1-phosphate guanyltransferase 0.0036 0.004 0.0077
Echinococcus granulosus rhodopsin orphan GPCR 0.0056 0.0067 0.0113
Brugia malayi zgc:92842 0.0035 0.0038 0.0621
Schistosoma mansoni glutamate receptor kainate 0.0419 0.0567 0.1191
Loa Loa (eye worm) hypothetical protein 0.0056 0.0067 0.1184
Echinococcus multilocularis mothers against decapentaplegic 5 0.0009 0.0003 0.0005
Loa Loa (eye worm) hypothetical protein 0.0056 0.0067 0.1184
Echinococcus multilocularis rhodopsin orphan GPCR 0.0056 0.0067 0.0113
Echinococcus multilocularis geminin 0.0194 0.0257 0.0434
Trypanosoma cruzi GDP-mannose pyrophosphorylase 0.0036 0.004 0.0906
Schistosoma mansoni hypothetical protein 0.0056 0.0067 0.0135
Onchocerca volvulus Atrial natriuretic peptide receptor 3 homolog 0.0215 0.0286 0.595
Loa Loa (eye worm) dynactin 5 0.0035 0.0038 0.0675
Echinococcus multilocularis glutamate receptor 2 0.0633 0.0863 0.1457
Loa Loa (eye worm) hypothetical protein 0.0215 0.0286 0.5044
Brugia malayi Nucleotidyl transferase family protein 0.0036 0.004 0.0649
Loa Loa (eye worm) hypothetical protein 0.0056 0.0067 0.1184
Schistosoma mansoni glutamate receptor AMPA 0.0419 0.0567 0.1191
Brugia malayi GnHR receptor homolog 0.0056 0.0067 0.1133
Loa Loa (eye worm) MH2 domain-containing protein 0.0136 0.0178 0.3146
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0056 0.0067 0.1184
Echinococcus granulosus mothers against decapentaplegic 5 0.0009 0.0003 0.0005
Echinococcus multilocularis rhodopsin orphan GPCR 0.0056 0.0067 0.0113
Trypanosoma cruzi extracellular receptor, putative 0.0215 0.0286 1
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0056 0.0067 0.1133
Loa Loa (eye worm) metabotropic glutamate receptor 8 0.0215 0.0286 0.5044
Brugia malayi hypothetical protein 0.0035 0.0038 0.0621
Brugia malayi Receptor family ligand binding region containing protein 0.0215 0.0286 0.5016
Trypanosoma cruzi PAB1-binding protein , putative 0.0029 0.003 0.0547
Loa Loa (eye worm) hypothetical protein 0.0215 0.0286 0.5044
Echinococcus multilocularis G protein coupled receptor 139 0.0056 0.0067 0.0113
Echinococcus granulosus geminin 0.0194 0.0257 0.0434
Schistosoma mansoni histamine h1 receptor 0.0056 0.0067 0.0135
Echinococcus multilocularis rhodopsin orphan GPCR 0.0056 0.0067 0.0113
Schistosoma mansoni metabotropic glutamate receptor 0.0215 0.0286 0.0597
Schistosoma mansoni opsin-like receptor 0.0056 0.0067 0.0135
Echinococcus granulosus dynactin 5 p25 0.0035 0.0038 0.0065
Echinococcus multilocularis dro:myosuppressin receptor 0.0056 0.0067 0.0113
Brugia malayi hypothetical protein 0.0035 0.0038 0.0621
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0056 0.0067 0.0135
Loa Loa (eye worm) hypothetical protein 0.0056 0.0067 0.1184
Brugia malayi hypothetical protein 0.0215 0.0286 0.5016
Echinococcus multilocularis isocitrate dehydrogenase 0.0018 0.0015 0.0026
Mycobacterium ulcerans glutamine-binding lipoprotein GlnH 0.1073 0.1468 0.1436
Echinococcus granulosus atrial natriuretic peptide receptor 0.0215 0.0286 0.0483
Loa Loa (eye worm) transcription factor SMAD2 0.0136 0.0178 0.3146
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0056 0.0067 0.0113
Onchocerca volvulus 0.0056 0.0067 0.1029
Trypanosoma cruzi GDP-mannose pyrophosphorylase 0.0036 0.004 0.0906
Loa Loa (eye worm) hypothetical protein 0.0056 0.0067 0.1184
Echinococcus granulosus neuropeptide receptor 0.0056 0.0067 0.0113
Echinococcus granulosus rhodopsin orphan GPCR 0.0056 0.0067 0.0113
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0056 0.0067 0.1184
Echinococcus multilocularis neuropeptide FF receptor 2 0.0056 0.0067 0.0113
Echinococcus multilocularis receptor type guanylyl cyclase 0.0215 0.0286 0.0483
Echinococcus granulosus glutamate NMDA receptor subunit 0.0419 0.0567 0.0958
Schistosoma mansoni neuropeptide receptor 0.0056 0.0067 0.0135
Echinococcus multilocularis fmrfamide receptor 0.0056 0.0067 0.0113
Echinococcus granulosus dnaJ subfamily B 0.032 0.0431 0.0728
Echinococcus granulosus 7TM GPCR rhodopsin 0.0056 0.0067 0.0113
Brugia malayi MH2 domain containing protein 0.0136 0.0178 0.3106
Brugia malayi G-protein coupled receptor 0.0056 0.0067 0.1133
Loa Loa (eye worm) hypothetical protein 0.0035 0.0038 0.0675
Echinococcus multilocularis serotonin receptor 0.0056 0.0067 0.0113
Echinococcus multilocularis somatostatin receptor 0.0056 0.0067 0.0113
Loa Loa (eye worm) hypothetical protein 0.0056 0.0067 0.1184
Plasmodium falciparum liver specific protein 2, putative 0.0035 0.0038 0.9368
Loa Loa (eye worm) hypothetical protein 0.0215 0.0286 0.5044
Wolbachia endosymbiont of Brugia malayi N-acetylglucosamine-1-phosphate uridyltransferase 0.7267 1 1
Brugia malayi isocitrate dehydrogenase 0.0018 0.0015 0.0214
Trypanosoma cruzi hypothetical protein 0.0035 0.0038 0.0848
Schistosoma mansoni biogenic amine receptor 0.0056 0.0067 0.0135
Schistosoma mansoni biogenic amine receptor 0.0056 0.0067 0.0135
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0056 0.0067 0.0113
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0056 0.0067 0.1184
Brugia malayi Glutamate receptor 1 precursor 0.0419 0.0567 1
Schistosoma mansoni neuropeptide F-like receptor 0.0056 0.0067 0.0135
Onchocerca volvulus 0.0056 0.0067 0.1029
Brugia malayi hypothetical protein 0.0056 0.0067 0.1133
Echinococcus granulosus 7tm_1 domain containing protein 0.0056 0.0067 0.0113
Schistosoma mansoni glutamate receptor kainate 0.0419 0.0567 0.1191
Echinococcus granulosus glutamate receptor ionotrophic AMPA 3 0.0633 0.0863 0.1457
Toxoplasma gondii eukaryotic initiation factor-2B, epsilon subunit, putative 0.0035 0.0038 0.0134
Loa Loa (eye worm) hypothetical protein 0.0215 0.0286 0.5044
Leishmania major hypothetical protein, conserved 0.0035 0.0038 0.0848
Trichomonas vaginalis sugar-1-phosphate guanyl transferase, putative 0.0036 0.004 1
Echinococcus granulosus mannose 1 phosphate guanyltransferase beta 0.0035 0.0038 0.0065
Echinococcus multilocularis rhodopsin orphan GPCR 0.0056 0.0067 0.0113
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0633 0.0863 0.1457
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0056 0.0067 0.0135
Brugia malayi hypothetical protein 0.0056 0.0067 0.1133
Onchocerca volvulus 0.0215 0.0286 0.595
Echinococcus multilocularis fmrfamide receptor 0.0056 0.0067 0.0113
Loa Loa (eye worm) hypothetical protein 0.0215 0.0286 0.5044
Echinococcus multilocularis neuropeptide Y receptor 0.0056 0.0067 0.0113
Brugia malayi AKH receptor 0.0056 0.0067 0.1133
Brugia malayi Tachykinin-like peptides receptor 99D 0.0056 0.0067 0.1133
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0038 0.0848
Onchocerca volvulus 0.0215 0.0286 0.595
Echinococcus multilocularis Smad4 0.0009 0.0003 0.0005
Echinococcus granulosus orexin receptor type 2 0.0056 0.0067 0.0113
Echinococcus granulosus neuropeptides capa receptor 0.0056 0.0067 0.0113
Loa Loa (eye worm) hypothetical protein 0.0056 0.0067 0.1184
Echinococcus granulosus nmda type glutamate receptor 0.4304 0.5919 1
Plasmodium falciparum ataxin-2 like protein, putative 0.0029 0.003 0.604
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0056 0.0067 0.0113
Echinococcus multilocularis GPCR, family 2 0.0018 0.0015 0.0026
Toxoplasma gondii GDP-D-mannose pyrophosphorylase 0.0036 0.004 0.0143
Plasmodium vivax ataxin-2 like protein, putative 0.0029 0.003 0.604
Echinococcus multilocularis neuropeptide Y receptor 0.0056 0.0067 0.0113
Schistosoma mansoni amine GPCR 0.0056 0.0067 0.0135
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0056 0.0067 0.0113
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0056 0.0067 0.0113
Echinococcus granulosus tm gpcr rhodopsin 0.0056 0.0067 0.0113
Brugia malayi hypothetical protein 0.0056 0.0067 0.1133
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0056 0.0067 0.1184
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0056 0.0067 0.0113
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0056 0.0067 0.0113
Brugia malayi Serotonin receptor 0.0056 0.0067 0.1133
Schistosoma mansoni hypothetical protein 0.0018 0.0015 0.0025
Schistosoma mansoni protein kinase 0.0215 0.0286 0.0597
Brugia malayi hypothetical protein 0.0019 0.0016 0.0227
Loa Loa (eye worm) hypothetical protein 0.0056 0.0067 0.1184
Loa Loa (eye worm) hypothetical protein 0.0056 0.0067 0.1184
Echinococcus granulosus rhodopsin orphan GPCR 0.0056 0.0067 0.0113
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0038 0.0848
Loa Loa (eye worm) hypothetical protein 0.0039 0.0044 0.0777
Echinococcus granulosus peptide allatostatin:somatostatin 0.0056 0.0067 0.0113
Schistosoma mansoni hypothetical protein 0.0056 0.0067 0.0135
Loa Loa (eye worm) MH1 domain-containing protein 0.0009 0.0003 0.0057
Loa Loa (eye worm) TYRA-2 protein 0.0056 0.0067 0.1184
Onchocerca volvulus 0.0056 0.0067 0.1029
Echinococcus granulosus neuropeptide Y receptor 0.0056 0.0067 0.0113
Schistosoma mansoni glutamate receptor NMDA 0.3446 0.4737 1
Mycobacterium ulcerans d-alpha-D-mannose-1-phosphate guanylyltransferase ManB 0.0036 0.004 0.0002
Schistosoma mansoni cpg binding protein 0.0022 0.0021 0.0038
Echinococcus granulosus glutamate receptor NMDA 0.2813 0.3865 0.6529
Onchocerca volvulus Neuropeptide F receptor homolog 0.0056 0.0067 0.1029
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0633 0.0863 0.1457
Echinococcus granulosus g protein coupled receptor 0.0056 0.0067 0.0113
Schistosoma mansoni neuropeptide f receptor 76f 0.0056 0.0067 0.0135
Schistosoma mansoni hypothetical protein 0.0056 0.0067 0.0135
Brugia malayi Dopamine receptor protein 2 0.0056 0.0067 0.1133
Echinococcus granulosus biogenic amine 5HT receptor 0.0056 0.0067 0.0113
Leishmania major GDP-mannose pyrophosphorylase 0.0036 0.004 0.0906
Schistosoma mansoni glucosamine-1-phosphate N-acetyltransferase 0.0036 0.004 0.0077
Brugia malayi sulfakinin receptor protein 0.0056 0.0067 0.1133
Schistosoma mansoni growth hormone secretagogue receptor 0.0056 0.0067 0.0135
Loa Loa (eye worm) hypothetical protein 0.0056 0.0067 0.1184
Schistosoma mansoni hypothetical protein 0.0419 0.0567 0.1191
Brugia malayi hypothetical protein 0.0056 0.0067 0.1133
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0056 0.0067 0.0135
Echinococcus granulosus allatostatin A receptor 0.0056 0.0067 0.0113
Loa Loa (eye worm) hypothetical protein 0.0345 0.0466 0.8222
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 3 0.1491 0.2045 0.3455
Echinococcus granulosus Smad4 0.0009 0.0003 0.0005
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0056 0.0067 0.0113
Echinococcus granulosus serotonin receptor 0.0056 0.0067 0.0113
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0056 0.0067 0.0135
Schistosoma mansoni glutamate receptor NMDA 0.0419 0.0567 0.1191
Echinococcus granulosus glutamate receptor subunit protein glur 0.0419 0.0567 0.0958
Brugia malayi Receptor family ligand binding region containing protein 0.0215 0.0286 0.5016
Brugia malayi hypothetical protein 0.0056 0.0067 0.1133
Leishmania major hypothetical protein, conserved 0.0029 0.003 0.0547
Entamoeba histolytica hypothetical protein 0.0215 0.0286 1
Echinococcus granulosus GPCR family 2 0.0018 0.0015 0.0026
Echinococcus granulosus nmda type glutamate receptor 0.3027 0.416 0.7028
Brugia malayi Dopamine receptor protein 1 0.0056 0.0067 0.1133
Echinococcus multilocularis glutamate receptor 2 0.0419 0.0567 0.0958
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0056 0.0067 0.0113
Schistosoma mansoni hypothetical protein 0.0013 0.0008 0.0011
Brugia malayi hypothetical protein 0.0056 0.0067 0.1133
Trypanosoma cruzi serine acetyltransferase, putative 0.0035 0.0038 0.0848
Schistosoma mansoni DNA polymerase epsilon catalytic subunit 0.0035 0.0038 0.0074
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0056 0.0067 0.0135
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0056 0.0067 0.0113
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0056 0.0067 0.0135
Loa Loa (eye worm) metabotropic GABA-B receptor subtype 2 0.0215 0.0286 0.5044
Brugia malayi Isocitrate dehydrogenase 0.0018 0.0015 0.0214
Schistosoma mansoni glutamate receptor AMPA 0.0419 0.0567 0.1191
Chlamydia trachomatis arginine ABC transporter substrate-binding protein ArtJ 0.1073 0.1468 1
Schistosoma mansoni hypothetical protein 0.0018 0.0015 0.0025
Schistosoma mansoni hypothetical protein 0.0056 0.0067 0.0135
Echinococcus multilocularis neuropeptides capa receptor 0.0056 0.0067 0.0113
Chlamydia trachomatis glutamine binding protein 0.1073 0.1468 1
Brugia malayi Dopamine receptor 0.0056 0.0067 0.1133
Echinococcus granulosus rhodopsin orphan GPCR 0.0056 0.0067 0.0113
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0056 0.0067 0.1133
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0633 0.0863 0.1457
Brugia malayi metabotropic GABA-B receptor subtype 2 0.0215 0.0286 0.5016
Loa Loa (eye worm) hypothetical protein 0.0056 0.0067 0.1184
Echinococcus granulosus biogenic amine 5HT receptor 0.0056 0.0067 0.0113
Echinococcus granulosus neuropeptides capa receptor 0.0056 0.0067 0.0113
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0056 0.0067 0.0135
Loa Loa (eye worm) hypothetical protein 0.0056 0.0067 0.1184
Brugia malayi CXXC zinc finger family protein 0.0022 0.0021 0.0321
Loa Loa (eye worm) hypothetical protein 0.0056 0.0067 0.1184
Onchocerca volvulus 0.0056 0.0067 0.1029
Plasmodium falciparum dynactin subunit 5, putative 0.0035 0.0038 0.9368
Brugia malayi G protein-coupled receptor F59B2.13 0.0056 0.0067 0.1133
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0633 0.0863 0.1457
Echinococcus multilocularis allatostatin A receptor 0.0056 0.0067 0.0113
Mycobacterium tuberculosis Probable serine acetyltransferase CysE (sat) 0.0035 0.0038 0.0023
Toxoplasma gondii eukaryotic initiation factor-2B, gamma subunit, putative 0.1262 0.1729 1
Echinococcus granulosus rhodopsin orphan GPCR 0.0056 0.0067 0.0113
Echinococcus multilocularis G-protein coupled receptor, putative 0.0056 0.0067 0.0113
Loa Loa (eye worm) hypothetical protein 0.0056 0.0067 0.1184
Brugia malayi putative neuropeptide receptor 0.0056 0.0067 0.1133
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0056 0.0067 0.0135
Echinococcus granulosus tm gpcr rhodopsin 0.0056 0.0067 0.0113
Brugia malayi Calcitonin receptor-like protein seb-1 0.0057 0.0069 0.1165
Loa Loa (eye worm) receptor family ligand binding region containing protein 0.0215 0.0286 0.5044
Loa Loa (eye worm) hypothetical protein 0.0215 0.0286 0.5044
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0056 0.0067 0.0135
Loa Loa (eye worm) hypothetical protein 0.0056 0.0067 0.1184
Echinococcus multilocularis neuropeptide receptor A26 0.0056 0.0067 0.0113
Brugia malayi neuropeptide F receptor 0.0056 0.0067 0.1133
Onchocerca volvulus 0.0056 0.0067 0.1029
Leishmania major serine acetyltransferase 0.0035 0.0038 0.0848
Echinococcus granulosus somatostatin receptor 0.0056 0.0067 0.0113
Plasmodium falciparum ataxin-2 like protein, putative 0.0029 0.003 0.604
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0056 0.0067 0.0113
Brugia malayi larval opioid receptor 0.0056 0.0067 0.1133
Trypanosoma cruzi serine acetyltransferase, putative 0.0035 0.0038 0.0848
Loa Loa (eye worm) hypothetical protein 0.0056 0.0067 0.1184
Mycobacterium tuberculosis Probable UDP-N-acetylglucosamine pyrophosphorylase GlmU 0.7267 1 1
Loa Loa (eye worm) G-protein coupled receptor 0.0056 0.0067 0.1184
Echinococcus granulosus receptor type guanylyl cyclase 0.0215 0.0286 0.0483
Schistosoma mansoni hypothetical protein 0.0035 0.0038 0.0074
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0056 0.0067 0.1133
Schistosoma mansoni amine GPCR 0.0056 0.0067 0.0135
Echinococcus multilocularis g protein coupled receptor 0.0056 0.0067 0.0113
Echinococcus multilocularis rhodopsin orphan GPCR 0.0056 0.0067 0.0113
Schistosoma mansoni alpha-1 adrenergic receptor 0.0056 0.0067 0.0135
Echinococcus granulosus metabotropic glutamate receptor 5 0.0215 0.0286 0.0483
Toxoplasma gondii hypothetical protein 0.0035 0.0038 0.0134
Echinococcus multilocularis g protein coupled receptor 0.0056 0.0067 0.0113
Loa Loa (eye worm) hypothetical protein 0.0056 0.0067 0.1184
Trypanosoma brucei hypothetical protein, conserved 0.0035 0.0038 0.9368
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0056 0.0067 0.0135
Brugia malayi latrophilin 2 splice variant baaae 0.0039 0.0044 0.0724
Echinococcus granulosus cpg binding protein 0.0024 0.0023 0.0039
Schistosoma mansoni amine GPCR 0.0056 0.0067 0.0135
Loa Loa (eye worm) hypothetical protein 0.0056 0.0067 0.1184
Loa Loa (eye worm) hypothetical protein 0.0056 0.0067 0.1184
Schistosoma mansoni adenoreceptor 0.0056 0.0067 0.0135
Schistosoma mansoni opsin-like receptor 0.0056 0.0067 0.0135
Echinococcus multilocularis neuropeptides capa receptor 0.0056 0.0067 0.0113
Schistosoma mansoni dynactin subunit P25 0.0035 0.0038 0.0074
Echinococcus granulosus glutamate receptor ionotropic kainate 3 0.0419 0.0567 0.0958
Loa Loa (eye worm) hypothetical protein 0.0056 0.0067 0.1184
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0056 0.0067 0.0135
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0056 0.0067 0.1184
Echinococcus granulosus neuropeptide receptor 0.0056 0.0067 0.0113
Brugia malayi hypothetical protein 0.0056 0.0067 0.1133
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0056 0.0067 0.0135
Echinococcus granulosus glutamate receptor 2 0.0633 0.0863 0.1457
Onchocerca volvulus 0.0056 0.0067 0.1029
Echinococcus granulosus Ribosomal protein S1 RNA binding domain 0.0419 0.0567 0.0958
Loa Loa (eye worm) Smad1 0.0009 0.0003 0.0057
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0018 0.0015 0.0026
Loa Loa (eye worm) hypothetical protein 0.0056 0.0067 0.1184
Loa Loa (eye worm) hypothetical protein 0.0056 0.0067 0.1184
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0018 0.0015 0.0026
Echinococcus granulosus dro:myosuppressin receptor 0.0056 0.0067 0.0113
Loa Loa (eye worm) hypothetical protein 0.0056 0.0067 0.1184
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0048 0.0056 0.0111
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0056 0.0067 0.0135
Echinococcus multilocularis glutamate receptor NMDA 0.2813 0.3865 0.6529
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0056 0.0067 0.0135
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0038 0.0848
Leishmania major hypothetical protein, conserved 0.0035 0.0038 0.0848
Brugia malayi hypothetical protein 0.0029 0.003 0.0477
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0018 0.0015 0.0026
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0018 0.0015 0.0026
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0056 0.0067 0.0135
Echinococcus multilocularis glutamate (NMDA) receptor subunit 0.0419 0.0567 0.0958
Trypanosoma cruzi Translation initiation factor eIF-2B subunit epsilon, putative 0.0036 0.004 0.0906
Loa Loa (eye worm) hypothetical protein 0.0056 0.0067 0.1184
Echinococcus granulosus neuropeptide FF receptor 2 0.0056 0.0067 0.0113
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0056 0.0067 0.0113
Loa Loa (eye worm) GDP-mannose pyrophosphorylase B 0.0036 0.004 0.0702
Leishmania major extracellular receptor, putative 0.0215 0.0286 1
Echinococcus multilocularis atrial natriuretic peptide receptor 0.0215 0.0286 0.0483
Echinococcus multilocularis serotonin receptor 0.0056 0.0067 0.0113
Toxoplasma gondii LsmAD domain-containing protein 0.0029 0.003 0.0086
Mycobacterium tuberculosis Conserved hypothetical protein 0.0035 0.0038 0.0023
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0056 0.0067 0.0113
Schistosoma mansoni cpg binding protein 0.0024 0.0023 0.0042
Echinococcus multilocularis rhodopsin orphan GPCR 0.0056 0.0067 0.0113
Schistosoma mansoni myosin xvIII 0.0056 0.0067 0.0135
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0056 0.0067 0.0135
Echinococcus granulosus alpha 1A adrenergic receptor 0.0056 0.0067 0.0113
Schistosoma mansoni biogenic amine receptor 0.0056 0.0067 0.0135
Schistosoma mansoni hypothetical protein 0.0194 0.0257 0.0536
Loa Loa (eye worm) hypothetical protein 0.0056 0.0067 0.1184
Brugia malayi neuropeptide F receptor 0.0056 0.0067 0.1133
Brugia malayi hypothetical protein 0.0056 0.0067 0.1133
Plasmodium vivax dynactin subunit 5, putative 0.0035 0.0038 0.9368
Loa Loa (eye worm) G-protein coupled receptor 0.0056 0.0067 0.1184
Echinococcus multilocularis tyrosine kinase 0.0215 0.0286 0.0483
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0018 0.0015 0.0026
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0018 0.0015 0.0026
Trichomonas vaginalis glucose-1-phosphate thymidylyltransferase, putative 0.0036 0.004 1
Trypanosoma brucei hypothetical protein, conserved 0.0035 0.0038 0.9368
Echinococcus granulosus mannose 1 phosphate guanyltransferase 0.0036 0.004 0.0067
Echinococcus multilocularis mannose 1 phosphate guanyltransferase beta 0.0036 0.004 0.0067
Schistosoma mansoni neuropeptide F-like receptor 0.0056 0.0067 0.0135
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0057 0.0069 0.1165
Loa Loa (eye worm) neuropeptide F receptor 0.0056 0.0067 0.1184
Schistosoma mansoni hypothetical protein 0.0194 0.0257 0.0536
Echinococcus multilocularis neuropeptide s receptor 0.0056 0.0067 0.0113
Loa Loa (eye worm) latrophilin receptor protein 2 0.0018 0.0015 0.0269
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0056 0.0067 0.0113
Echinococcus granulosus hypothetical protein 0.0056 0.0067 0.0113
Brugia malayi Melatonin receptor type 1A 0.0056 0.0067 0.1133
Plasmodium vivax mannose-1-phosphate guanyltransferase, putative 0.0036 0.004 1
Brugia malayi metabotropic glutamate receptor type 2 0.0215 0.0286 0.5016
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0035 0.0038 0.9368
Schistosoma mansoni hypothetical protein 0.0039 0.0044 0.0086
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0057 0.0069 0.1215
Mycobacterium tuberculosis Possible transferase 0.0035 0.0038 0.0023
Schistosoma mansoni cpg binding protein 0.0024 0.0023 0.0042
Loa Loa (eye worm) neuropeptide F receptor 0.0056 0.0067 0.1184
Trypanosoma brucei hypothetical protein, conserved 0.0035 0.0038 0.9368
Loa Loa (eye worm) RGC/RGC protein kinase 0.0215 0.0286 0.5044
Brugia malayi Serotonin receptor 0.0056 0.0067 0.1133
Mycobacterium ulcerans bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase 0.7267 1 1
Plasmodium vivax hypothetical protein, conserved 0.0035 0.0038 0.9368
Loa Loa (eye worm) hypothetical protein 0.0056 0.0067 0.1184
Mycobacterium tuberculosis Conserved hypothetical protein 0.1262 0.1729 0.1716
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0056 0.0067 0.0135
Trypanosoma cruzi PAB1-binding protein , putative 0.0029 0.003 0.0547
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0013 0.0008 0.0014
Loa Loa (eye worm) hypothetical protein 0.0215 0.0286 0.5044
Loa Loa (eye worm) glutamate receptor 2 0.0419 0.0567 1
Loa Loa (eye worm) hypothetical protein 0.0056 0.0067 0.1184
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0056 0.0067 0.0135
Echinococcus multilocularis neuropeptide receptor 0.0056 0.0067 0.0113
Brugia malayi Glutamate receptor 2 precursor 0.0419 0.0567 1
Loa Loa (eye worm) GDP-mannose pyrophosphorylase B 0.0035 0.0038 0.0675
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0056 0.0067 0.0113
Echinococcus multilocularis rhodopsin orphan GPCR 0.0056 0.0067 0.0113
Schistosoma mansoni neuropeptide receptor 0.0056 0.0067 0.0135
Onchocerca volvulus 0.0345 0.0466 1
Echinococcus multilocularis glutamate receptor ionotropic kainate 0.0419 0.0567 0.0958
Trypanosoma brucei GDP-mannose pyrophosphorylase 0.0036 0.004 1
Loa Loa (eye worm) hypothetical protein 0.0215 0.0286 0.5044
Brugia malayi hypothetical protein 0.0035 0.0038 0.0621
Brugia malayi eIF4-gamma/eIF5/eIF2-epsilon family protein 0.0035 0.0038 0.0621
Echinococcus multilocularis sex peptide receptor 0.0056 0.0067 0.0113
Echinococcus granulosus g protein coupled receptor 0.0056 0.0067 0.0113
Echinococcus multilocularis glutamate receptor 2 0.0215 0.0286 0.0483
Schistosoma mansoni ATP-binding cassette transporter 0.0419 0.0567 0.1191
Echinococcus granulosus tm gpcr rhodopsin 0.0056 0.0067 0.0113
Loa Loa (eye worm) hypothetical protein 0.0056 0.0067 0.1184
Loa Loa (eye worm) hypothetical protein 0.0056 0.0067 0.1184
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0056 0.0067 0.0113
Brugia malayi ORL1-like opioid receptor 0.0056 0.0067 0.1133
Mycobacterium tuberculosis Possible siderophore-binding protein 0.0035 0.0038 0.0023
Schistosoma mansoni opsin-like receptor 0.0056 0.0067 0.0135
Schistosoma mansoni biogenic amine (5HT) receptor 0.0056 0.0067 0.0135
Loa Loa (eye worm) MH2 domain-containing protein 0.0009 0.0003 0.0057
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0018 0.0015 0.0213
Loa Loa (eye worm) CXXC zinc finger family protein 0.0022 0.0021 0.0377
Schistosoma mansoni tyrosine kinase 0.0215 0.0286 0.0597
Mycobacterium tuberculosis Probable glutamine-binding lipoprotein GlnH (GLNBP) 0.1073 0.1468 0.1455
Loa Loa (eye worm) hypothetical protein 0.0215 0.0286 0.5044
Loa Loa (eye worm) hypothetical protein 0.0056 0.0067 0.1184
Loa Loa (eye worm) RGC/RGC protein kinase 0.0215 0.0286 0.5044
Onchocerca volvulus 0.0056 0.0067 0.1029
Schistosoma mansoni tyrosine kinase 0.0215 0.0286 0.0597
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0009 0.0003 0.0005
Onchocerca volvulus 0.0056 0.0067 0.1029
Loa Loa (eye worm) hypothetical protein 0.0056 0.0067 0.1184
Loa Loa (eye worm) RGC/RGC protein kinase 0.0215 0.0286 0.5044
Brugia malayi G-protein coupled receptor 0.0056 0.0067 0.1133
Loa Loa (eye worm) hypothetical protein 0.0056 0.0067 0.1184
Loa Loa (eye worm) hypothetical protein 0.0056 0.0067 0.1184
Echinococcus granulosus neuropeptide Y receptor 0.0056 0.0067 0.0113
Echinococcus multilocularis nmda type glutamate receptor 0.3027 0.416 0.7028
Treponema pallidum licC protein (licC) 0.1262 0.1729 1
Loa Loa (eye worm) hypothetical protein 0.0056 0.0067 0.1184

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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