Detailed information for compound 797120

Basic information

Technical information
  • TDR Targets ID: 797120
  • Name: N-(3-methylphenyl)-3-[(1-propanoyl-2,3-dihydr oindol-5-yl)sulfonyl]propanamide
  • MW: 400.491 | Formula: C21H24N2O4S
  • H donors: 1 H acceptors: 4 LogP: 2.19 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCC(=O)N1CCc2c1ccc(c2)S(=O)(=O)CCC(=O)Nc1cccc(c1)C
  • InChi: 1S/C21H24N2O4S/c1-3-21(25)23-11-9-16-14-18(7-8-19(16)23)28(26,27)12-10-20(24)22-17-6-4-5-15(2)13-17/h4-8,13-14H,3,9-12H2,1-2H3,(H,22,24)
  • InChiKey: LFZDOZYESPNAOL-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • N-(3-methylphenyl)-3-(1-propanoylindolin-5-yl)sulfonyl-propanamide
  • N-(3-methylphenyl)-3-[[1-(1-oxopropyl)-5-indolinyl]sulfonyl]propanamide
  • N-(3-methylphenyl)-3-(1-propionylindolin-5-yl)sulfonyl-propionamide
  • IDI1_004917
  • ChemDiv2_006202

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi isocitrate dehydrogenase 0.0018 0.0015 0.0214
Loa Loa (eye worm) MH2 domain-containing protein 0.0136 0.0178 0.3146
Schistosoma mansoni growth hormone secretagogue receptor 0.0056 0.0067 0.0135
Loa Loa (eye worm) hypothetical protein 0.0056 0.0067 0.1184
Schistosoma mansoni opsin-like receptor 0.0056 0.0067 0.0135
Mycobacterium ulcerans hypothetical protein 0.1262 0.1729 0.1697
Loa Loa (eye worm) hypothetical protein 0.0056 0.0067 0.1184
Loa Loa (eye worm) hypothetical protein 0.0039 0.0044 0.0777
Brugia malayi metabotropic GABA-B receptor subtype 2 0.0215 0.0286 0.5016
Loa Loa (eye worm) hypothetical protein 0.0056 0.0067 0.1184
Schistosoma mansoni hypothetical protein 0.0018 0.0015 0.0025
Loa Loa (eye worm) hypothetical protein 0.0056 0.0067 0.1184
Echinococcus multilocularis glutamate (NMDA) receptor subunit 0.0419 0.0567 0.0958
Brugia malayi hypothetical protein 0.0056 0.0067 0.1133
Schistosoma mansoni glutamate receptor NMDA 0.0419 0.0567 0.1191
Plasmodium falciparum dynactin subunit 5, putative 0.0035 0.0038 0.9368
Echinococcus granulosus glutamate receptor NMDA 0.2813 0.3865 0.6529
Trypanosoma brucei hypothetical protein, conserved 0.0035 0.0038 0.9368
Schistosoma mansoni biogenic amine receptor 0.0056 0.0067 0.0135
Schistosoma mansoni protein kinase 0.0215 0.0286 0.0597
Echinococcus multilocularis orexin receptor type 2 0.0056 0.0067 0.0113
Echinococcus multilocularis neuropeptides capa receptor 0.0056 0.0067 0.0113
Echinococcus granulosus serotonin receptor 0.0056 0.0067 0.0113
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0056 0.0067 0.0135
Schistosoma mansoni hypothetical protein 0.032 0.0431 0.0903
Loa Loa (eye worm) hypothetical protein 0.0215 0.0286 0.5044
Schistosoma mansoni glutamate receptor kainate 0.0419 0.0567 0.1191
Trypanosoma brucei hypothetical protein, conserved 0.0035 0.0038 0.9368
Loa Loa (eye worm) hypothetical protein 0.0056 0.0067 0.1184
Schistosoma mansoni hypothetical protein 0.0013 0.0008 0.0011
Loa Loa (eye worm) metabotropic glutamate receptor 8 0.0215 0.0286 0.5044
Loa Loa (eye worm) hypothetical protein 0.0018 0.0015 0.0269
Echinococcus multilocularis neuropeptide s receptor 0.0056 0.0067 0.0113
Brugia malayi ORL1-like opioid receptor 0.0056 0.0067 0.1133
Echinococcus granulosus glutamate NMDA receptor subunit 0.0419 0.0567 0.0958
Echinococcus multilocularis rhodopsin orphan GPCR 0.0056 0.0067 0.0113
Echinococcus multilocularis receptor type guanylyl cyclase 0.0215 0.0286 0.0483
Mycobacterium tuberculosis Conserved hypothetical protein 0.1262 0.1729 0.1716
Chlamydia trachomatis arginine ABC transporter substrate-binding protein ArtJ 0.1073 0.1468 1
Loa Loa (eye worm) hypothetical protein 0.0056 0.0067 0.1184
Loa Loa (eye worm) hypothetical protein 0.0215 0.0286 0.5044
Plasmodium falciparum ataxin-2 like protein, putative 0.0029 0.003 0.604
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0056 0.0067 0.0135
Echinococcus multilocularis neuropeptide receptor 0.0056 0.0067 0.0113
Echinococcus granulosus atrial natriuretic peptide receptor 0.0215 0.0286 0.0483
Loa Loa (eye worm) hypothetical protein 0.0056 0.0067 0.1184
Echinococcus multilocularis G protein coupled receptor 139 0.0056 0.0067 0.0113
Echinococcus multilocularis geminin 0.0194 0.0257 0.0434
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0056 0.0067 0.0135
Brugia malayi follicle stimulating hormone receptor 0.0056 0.0067 0.1133
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0056 0.0067 0.1133
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0056 0.0067 0.0113
Trypanosoma cruzi PAB1-binding protein , putative 0.0029 0.003 0.0547
Schistosoma mansoni hypothetical protein 0.0194 0.0257 0.0536
Trypanosoma cruzi Translation initiation factor eIF-2B subunit epsilon, putative 0.0036 0.004 0.0906
Schistosoma mansoni biogenic amine (5HT) receptor 0.0056 0.0067 0.0135
Loa Loa (eye worm) hypothetical protein 0.0056 0.0067 0.1184
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0056 0.0067 0.0135
Loa Loa (eye worm) G-protein coupled receptor 0.0056 0.0067 0.1184
Plasmodium vivax hypothetical protein, conserved 0.0035 0.0038 0.9368
Loa Loa (eye worm) hypothetical protein 0.0215 0.0286 0.5044
Brugia malayi Melatonin receptor type 1A 0.0056 0.0067 0.1133
Schistosoma mansoni adenoreceptor 0.0056 0.0067 0.0135
Echinococcus multilocularis g protein coupled receptor 0.0056 0.0067 0.0113
Echinococcus granulosus neuropeptide receptor A26 0.0056 0.0067 0.0113
Schistosoma mansoni myosin xvIII 0.0056 0.0067 0.0135
Echinococcus multilocularis Smad4 0.0009 0.0003 0.0005
Schistosoma mansoni tyrosine kinase 0.0215 0.0286 0.0597
Brugia malayi hypothetical protein 0.0056 0.0067 0.1133
Mycobacterium tuberculosis Conserved hypothetical protein 0.1262 0.1729 0.1716
Loa Loa (eye worm) hypothetical protein 0.0056 0.0067 0.1184
Loa Loa (eye worm) hypothetical protein 0.0056 0.0067 0.1184
Trypanosoma brucei hypothetical protein, conserved 0.0035 0.0038 0.9368
Onchocerca volvulus 0.0056 0.0067 0.1029
Loa Loa (eye worm) hypothetical protein 0.0215 0.0286 0.5044
Echinococcus multilocularis mannose 1 phosphate guanyltransferase beta 0.0036 0.004 0.0067
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0056 0.0067 0.0113
Echinococcus multilocularis atrial natriuretic peptide receptor 0.0215 0.0286 0.0483
Trypanosoma cruzi PAB1-binding protein , putative 0.0029 0.003 0.0547
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0048 0.0056 0.0111
Echinococcus multilocularis rhodopsin orphan GPCR 0.0056 0.0067 0.0113
Echinococcus granulosus glutamate receptor ionotropic kainate 0.0419 0.0567 0.0958
Loa Loa (eye worm) hypothetical protein 0.0056 0.0067 0.1184
Echinococcus multilocularis glutamate receptor 2 0.0633 0.0863 0.1457
Mycobacterium tuberculosis Possible transferase 0.0035 0.0038 0.0023
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0056 0.0067 0.1184
Echinococcus granulosus tm gpcr rhodopsin 0.0056 0.0067 0.0113
Loa Loa (eye worm) metabotropic GABA-B receptor subtype 2 0.0215 0.0286 0.5044
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0035 0.0038 0.9368
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0056 0.0067 0.0113
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0056 0.0067 0.1133
Schistosoma mansoni hypothetical protein 0.0419 0.0567 0.1191
Brugia malayi hypothetical protein 0.0056 0.0067 0.1133
Schistosoma mansoni glutamate receptor NMDA 0.3446 0.4737 1
Echinococcus granulosus rhodopsin orphan GPCR 0.0056 0.0067 0.0113
Echinococcus multilocularis cpg binding protein 0.0024 0.0023 0.0039
Entamoeba histolytica hypothetical protein 0.0215 0.0286 1
Echinococcus granulosus mannose 1 phosphate guanyltransferase beta 0.0036 0.004 0.0067
Echinococcus granulosus receptor type guanylyl cyclase 0.0215 0.0286 0.0483
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0056 0.0067 0.0135
Echinococcus granulosus dynactin 5 p25 0.0035 0.0038 0.0065
Giardia lamblia Translation initiation factor 0.0035 0.0038 0.5
Echinococcus multilocularis somatostatin receptor 0.0056 0.0067 0.0113
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0057 0.0069 0.1215
Brugia malayi hypothetical protein 0.0056 0.0067 0.1133
Schistosoma mansoni neuropeptide receptor 0.0056 0.0067 0.0135
Echinococcus granulosus hypothetical protein 0.0056 0.0067 0.0113
Echinococcus multilocularis serotonin receptor 0.0056 0.0067 0.0113
Schistosoma mansoni hypothetical protein 0.0039 0.0044 0.0086
Onchocerca volvulus Atrial natriuretic peptide receptor 3 homolog 0.0215 0.0286 0.595
Chlamydia trachomatis glutamine binding protein 0.1073 0.1468 1
Echinococcus multilocularis dnaJ subfamily B 0.032 0.0431 0.0728
Loa Loa (eye worm) hypothetical protein 0.0056 0.0067 0.1184
Loa Loa (eye worm) hypothetical protein 0.0056 0.0067 0.1184
Echinococcus multilocularis rhodopsin orphan GPCR 0.0056 0.0067 0.0113
Loa Loa (eye worm) neuropeptide F receptor 0.0056 0.0067 0.1184
Echinococcus granulosus nmda type glutamate receptor 0.3027 0.416 0.7028
Brugia malayi Serotonin receptor 0.0056 0.0067 0.1133
Echinococcus multilocularis nmda type glutamate receptor 0.3027 0.416 0.7028
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0056 0.0067 0.0113
Echinococcus multilocularis metabotropic glutamate receptor 5 0.0215 0.0286 0.0483
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0038 0.0848
Schistosoma mansoni biogenic amine receptor 0.0056 0.0067 0.0135
Loa Loa (eye worm) hypothetical protein 0.0056 0.0067 0.1184
Brugia malayi hypothetical protein 0.0056 0.0067 0.1133
Echinococcus granulosus tachykinin peptides receptor 99D 0.0056 0.0067 0.0113
Echinococcus granulosus sex peptide receptor 0.0056 0.0067 0.0113
Brugia malayi hypothetical protein 0.0345 0.0466 0.8211
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0056 0.0067 0.0113
Echinococcus multilocularis glutamate receptor NMDA 0.2813 0.3865 0.6529
Echinococcus multilocularis G-protein coupled receptor, putative 0.0056 0.0067 0.0113
Loa Loa (eye worm) hypothetical protein 0.0056 0.0067 0.1184
Loa Loa (eye worm) MH1 domain-containing protein 0.0009 0.0003 0.0057
Schistosoma mansoni amine GPCR 0.0056 0.0067 0.0135
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0056 0.0067 0.0113
Onchocerca volvulus 0.0056 0.0067 0.1029
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0056 0.0067 0.0113
Echinococcus multilocularis fmrfamide receptor 0.0056 0.0067 0.0113
Loa Loa (eye worm) hypothetical protein 0.0056 0.0067 0.1184
Loa Loa (eye worm) hypothetical protein 0.0056 0.0067 0.1184
Schistosoma mansoni cpg binding protein 0.0024 0.0023 0.0042
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0056 0.0067 0.0135
Echinococcus granulosus peptide allatostatin:somatostatin 0.0056 0.0067 0.0113
Echinococcus granulosus neuropeptide receptor 0.0056 0.0067 0.0113
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0018 0.0015 0.0026
Loa Loa (eye worm) hypothetical protein 0.0215 0.0286 0.5044
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0056 0.0067 0.0113
Echinococcus multilocularis rhodopsin orphan GPCR 0.0056 0.0067 0.0113
Loa Loa (eye worm) Smad1 0.0009 0.0003 0.0057
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0018 0.0015 0.0026
Echinococcus granulosus Ribosomal protein S1 RNA binding domain 0.0419 0.0567 0.0958
Treponema pallidum licC protein (licC) 0.1262 0.1729 1
Schistosoma mansoni ATP-binding cassette transporter 0.0419 0.0567 0.1191
Schistosoma mansoni DNA polymerase epsilon catalytic subunit 0.0035 0.0038 0.0074
Loa Loa (eye worm) hypothetical protein 0.0215 0.0286 0.5044
Brugia malayi CXXC zinc finger family protein 0.0022 0.0021 0.0321
Schistosoma mansoni metabotropic glutamate receptor 0.0215 0.0286 0.0597
Onchocerca volvulus 0.0056 0.0067 0.1029
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0056 0.0067 0.1133
Loa Loa (eye worm) GDP-mannose pyrophosphorylase B 0.0036 0.004 0.0702
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0056 0.0067 0.1133
Echinococcus multilocularis Ribosomal protein S1, RNA binding domain 0.0419 0.0567 0.0958
Brugia malayi MH2 domain containing protein 0.0136 0.0178 0.3106
Loa Loa (eye worm) hypothetical protein 0.0056 0.0067 0.1184
Plasmodium falciparum liver specific protein 2, putative 0.0035 0.0038 0.9368
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0056 0.0067 0.0113
Echinococcus granulosus Smad4 0.0009 0.0003 0.0005
Loa Loa (eye worm) hypothetical protein 0.0056 0.0067 0.1184
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0056 0.0067 0.1184
Schistosoma mansoni hypothetical protein 0.0056 0.0067 0.0135
Echinococcus granulosus cpg binding protein 0.0024 0.0023 0.0039
Loa Loa (eye worm) hypothetical protein 0.0056 0.0067 0.1184
Echinococcus granulosus biogenic amine 5HT receptor 0.0056 0.0067 0.0113
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0056 0.0067 0.0135
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0633 0.0863 0.1457
Echinococcus multilocularis g protein coupled receptor 0.0056 0.0067 0.0113
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0056 0.0067 0.0135
Brugia malayi Dopamine receptor protein 2 0.0056 0.0067 0.1133
Echinococcus granulosus rhodopsin orphan GPCR 0.0056 0.0067 0.0113
Brugia malayi Dopamine receptor protein 1 0.0056 0.0067 0.1133
Trypanosoma cruzi extracellular receptor, putative 0.0215 0.0286 1
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0056 0.0067 0.0113
Brugia malayi Receptor family ligand binding region containing protein 0.0215 0.0286 0.5016
Echinococcus granulosus tm gpcr rhodopsin 0.0056 0.0067 0.0113
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0056 0.0067 0.0113
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0018 0.0015 0.0025
Echinococcus multilocularis dro:myosuppressin receptor 0.0056 0.0067 0.0113
Echinococcus granulosus metabotropic glutamate receptor 2 0.0215 0.0286 0.0483
Echinococcus multilocularis dynactin 5 p25 0.0035 0.0038 0.0065
Brugia malayi GDP-mannose pyrophosphorylase B 0.0036 0.004 0.0649
Loa Loa (eye worm) hypothetical protein 0.0056 0.0067 0.1184
Brugia malayi putative neuropeptide receptor NPR1 0.0056 0.0067 0.1133
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0056 0.0067 0.1184
Schistosoma mansoni histamine h1 receptor 0.0056 0.0067 0.0135
Loa Loa (eye worm) TYRA-2 protein 0.0056 0.0067 0.1184
Loa Loa (eye worm) hypothetical protein 0.0056 0.0067 0.1184
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0056 0.0067 0.0135
Loa Loa (eye worm) hypothetical protein 0.0215 0.0286 0.5044
Loa Loa (eye worm) RGC/RGC protein kinase 0.0215 0.0286 0.5044
Echinococcus granulosus glutamate receptor 2 0.0215 0.0286 0.0483
Echinococcus multilocularis glutamate receptor 2 0.0419 0.0567 0.0958
Onchocerca volvulus 0.0215 0.0286 0.595
Schistosoma mansoni tyrosine kinase 0.0215 0.0286 0.0597
Loa Loa (eye worm) glutamate receptor 1 0.0419 0.0567 1
Echinococcus multilocularis glutamate receptor subunit protein glur 0.0419 0.0567 0.0958
Onchocerca volvulus 0.0056 0.0067 0.1029
Schistosoma mansoni hypothetical protein 0.0056 0.0067 0.0135
Echinococcus multilocularis NMDA receptor 0.0419 0.0567 0.0958
Onchocerca volvulus 0.0056 0.0067 0.1029
Echinococcus multilocularis tyrosine kinase 0.0215 0.0286 0.0483
Mycobacterium tuberculosis Conserved hypothetical protein 0.0035 0.0038 0.0023
Loa Loa (eye worm) G-protein coupled receptor 0.0056 0.0067 0.1184
Brugia malayi hypothetical protein 0.0019 0.0016 0.0227
Echinococcus granulosus TGF beta signal transducer SmadC 0.0009 0.0003 0.0005
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0056 0.0067 0.1184
Echinococcus granulosus g protein coupled receptor 0.0056 0.0067 0.0113
Onchocerca volvulus 0.0056 0.0067 0.1029
Mycobacterium ulcerans glutamine-binding lipoprotein GlnH 0.1073 0.1468 0.1436
Onchocerca volvulus 0.0215 0.0286 0.595
Leishmania major hypothetical protein, conserved 0.0035 0.0038 0.0848
Onchocerca volvulus 0.0345 0.0466 1
Plasmodium falciparum mannose-1-phosphate guanyltransferase, putative 0.0036 0.004 1
Loa Loa (eye worm) hypothetical protein 0.0056 0.0067 0.1184
Schistosoma mansoni opsin-like receptor 0.0056 0.0067 0.0135
Echinococcus granulosus glutamate receptor 2 0.0633 0.0863 0.1457
Schistosoma mansoni hypothetical protein 0.0018 0.0015 0.0025
Onchocerca volvulus 0.0056 0.0067 0.1029
Echinococcus granulosus g protein coupled receptor 0.0056 0.0067 0.0113
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0056 0.0067 0.0113
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0056 0.0067 0.0113
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0018 0.0015 0.0026
Leishmania major serine acetyltransferase 0.0035 0.0038 0.0848
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0056 0.0067 0.0113
Loa Loa (eye worm) hypothetical protein 0.0056 0.0067 0.1184
Leishmania major extracellular receptor, putative 0.0215 0.0286 1
Mycobacterium tuberculosis Probable UDP-N-acetylglucosamine pyrophosphorylase GlmU 0.7267 1 1
Schistosoma mansoni metabotropic glutamate receptor 0.0215 0.0286 0.0597
Echinococcus granulosus rhodopsin orphan GPCR 0.0056 0.0067 0.0113
Brugia malayi Nucleotidyl transferase family protein 0.0036 0.004 0.0649
Mycobacterium ulcerans bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase 0.7267 1 1
Brugia malayi hypothetical protein 0.0056 0.0067 0.1133
Echinococcus granulosus neuropeptide s receptor 0.0056 0.0067 0.0113
Loa Loa (eye worm) hypothetical protein 0.0035 0.0038 0.0675
Echinococcus granulosus rhodopsin orphan GPCR 0.0056 0.0067 0.0113
Echinococcus multilocularis smad 0.0009 0.0003 0.0005
Brugia malayi G-protein coupled receptor 0.0056 0.0067 0.1133
Loa Loa (eye worm) hypothetical protein 0.0056 0.0067 0.1184
Loa Loa (eye worm) hypothetical protein 0.0056 0.0067 0.1184
Schistosoma mansoni neuropeptide receptor 0.0056 0.0067 0.0135
Loa Loa (eye worm) nucleotidyl transferase 0.0036 0.004 0.0702
Loa Loa (eye worm) isocitrate dehydrogenase 0.0018 0.0015 0.027
Brugia malayi zgc:92842 0.0035 0.0038 0.0621
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0056 0.0067 0.0135
Echinococcus multilocularis allatostatin A receptor 0.0056 0.0067 0.0113
Trypanosoma cruzi GDP-mannose pyrophosphorylase 0.0036 0.004 0.0906
Brugia malayi Isocitrate dehydrogenase 0.0018 0.0015 0.0214
Loa Loa (eye worm) hypothetical protein 0.0056 0.0067 0.1184
Echinococcus multilocularis g-protein coupled receptor 0.0056 0.0067 0.0113
Schistosoma mansoni glucosamine-1-phosphate N-acetyltransferase 0.0036 0.004 0.0077
Loa Loa (eye worm) hypothetical protein 0.0035 0.0038 0.0675
Brugia malayi Guanylyl cyclase protein 23 0.0215 0.0286 0.5016
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 3 0.1491 0.2045 0.3455
Echinococcus granulosus neuropeptides capa receptor 0.0056 0.0067 0.0113
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0056 0.0067 0.0113
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0633 0.0863 0.1457
Schistosoma mansoni neuropeptide F-like receptor 0.0056 0.0067 0.0135
Loa Loa (eye worm) hypothetical protein 0.0056 0.0067 0.1184
Schistosoma mansoni glutamate receptor kainate 0.0419 0.0567 0.1191
Echinococcus granulosus glutamate receptor ionotropic kainate 3 0.0419 0.0567 0.0958
Loa Loa (eye worm) transcription factor SMAD2 0.0136 0.0178 0.3146
Schistosoma mansoni amine GPCR 0.0056 0.0067 0.0135
Echinococcus granulosus neuropeptides capa receptor 0.0056 0.0067 0.0113
Brugia malayi hypothetical protein 0.0056 0.0067 0.1133
Echinococcus granulosus glutamate receptor ionotrophic AMPA 3 0.0633 0.0863 0.1457
Trichomonas vaginalis sugar-1-phosphate guanyl transferase, putative 0.0036 0.004 1
Entamoeba histolytica translation initiation factor eIF-2B epsilon subunit, putative 0.0036 0.004 0.0063
Brugia malayi GnHR receptor homolog 0.0056 0.0067 0.1133
Loa Loa (eye worm) hypothetical protein 0.0056 0.0067 0.1184
Echinococcus granulosus orexin receptor type 2 0.0056 0.0067 0.0113
Schistosoma mansoni alpha-1 adrenergic receptor 0.0056 0.0067 0.0135
Schistosoma mansoni hypothetical protein 0.0035 0.0038 0.0074
Loa Loa (eye worm) hypothetical protein 0.0056 0.0067 0.1184
Toxoplasma gondii GDP-D-mannose pyrophosphorylase 0.0036 0.004 0.0143
Echinococcus granulosus neuropeptide Y receptor 0.0056 0.0067 0.0113
Echinococcus multilocularis mannose 1 phosphate guanyltransferase 0.0036 0.004 0.0067
Loa Loa (eye worm) hypothetical protein 0.0056 0.0067 0.1184
Brugia malayi latrophilin 2 splice variant baaae 0.0039 0.0044 0.0724
Brugia malayi Metabotropic glutamate receptor precursor. 0.0215 0.0286 0.5016
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0038 0.0848
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0056 0.0067 0.0113
Echinococcus granulosus 7TM GPCR rhodopsin 0.0056 0.0067 0.0113
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0056 0.0067 0.0135
Brugia malayi hypothetical protein 0.0035 0.0038 0.0621
Onchocerca volvulus Neuropeptide F receptor homolog 0.0056 0.0067 0.1029
Loa Loa (eye worm) hypothetical protein 0.0215 0.0286 0.5044
Schistosoma mansoni neuropeptide receptor 0.0056 0.0067 0.0135
Loa Loa (eye worm) hypothetical protein 0.0056 0.0067 0.1184
Echinococcus multilocularis neuropeptide Y receptor 0.0056 0.0067 0.0113
Brugia malayi RE15519p 0.0056 0.0067 0.1133
Loa Loa (eye worm) hypothetical protein 0.0056 0.0067 0.1184
Brugia malayi Calcitonin receptor-like protein seb-1 0.0057 0.0069 0.1165
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0018 0.0015 0.0026
Leishmania major hypothetical protein, conserved 0.0035 0.0038 0.0848
Schistosoma mansoni hypothetical protein 0.0056 0.0067 0.0135
Echinococcus multilocularis serotonin receptor 0.0056 0.0067 0.0113
Brugia malayi hypothetical protein 0.0035 0.0038 0.0621
Onchocerca volvulus 0.0056 0.0067 0.1029
Onchocerca volvulus 0.0056 0.0067 0.1029
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0018 0.0015 0.0026
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0056 0.0067 0.0135
Mycobacterium tuberculosis Possible siderophore-binding protein 0.0035 0.0038 0.0023
Echinococcus multilocularis isocitrate dehydrogenase 0.0018 0.0015 0.0026
Plasmodium vivax dynactin subunit 5, putative 0.0035 0.0038 0.9368
Leishmania major hypothetical protein, conserved 0.0029 0.003 0.0547
Trypanosoma brucei nucleotidyl transferase, putative 0.0036 0.004 1
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0056 0.0067 0.0113
Loa Loa (eye worm) CXXC zinc finger family protein 0.0022 0.0021 0.0377
Schistosoma mansoni amine GPCR 0.0056 0.0067 0.0135
Echinococcus granulosus alpha 1A adrenergic receptor 0.0056 0.0067 0.0113
Mycobacterium ulcerans hypothetical protein 0.1262 0.1729 0.1697
Echinococcus granulosus somatostatin receptor 0.0056 0.0067 0.0113
Loa Loa (eye worm) hypothetical protein 0.0057 0.0069 0.1215
Loa Loa (eye worm) receptor family ligand binding region containing protein 0.0215 0.0286 0.5044
Loa Loa (eye worm) hypothetical protein 0.0056 0.0067 0.1184
Loa Loa (eye worm) hypothetical protein 0.0056 0.0067 0.1184
Trypanosoma brucei PAB1-binding protein , putative 0.0029 0.003 0.604
Schistosoma mansoni hypothetical protein 0.0194 0.0257 0.0536
Loa Loa (eye worm) RGC/RGC protein kinase 0.0215 0.0286 0.5044
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0038 0.0848
Brugia malayi eIF4-gamma/eIF5/eIF2-epsilon family protein 0.0035 0.0038 0.0621
Onchocerca volvulus 0.0056 0.0067 0.1029
Brugia malayi hypothetical protein 0.0056 0.0067 0.1133
Trypanosoma cruzi GDP-mannose pyrophosphorylase 0.0036 0.004 0.0906
Loa Loa (eye worm) hypothetical protein 0.0215 0.0286 0.5044
Brugia malayi G protein-coupled receptor F59B2.13 0.0056 0.0067 0.1133
Loa Loa (eye worm) glutamate receptor 2 0.0419 0.0567 1
Echinococcus granulosus G protein coupled receptor 139 0.0056 0.0067 0.0113
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0056 0.0067 0.0135
Brugia malayi Glutamate receptor 1 precursor 0.0419 0.0567 1
Brugia malayi Tachykinin-like peptides receptor 99D 0.0056 0.0067 0.1133
Schistosoma mansoni amine GPCR 0.0056 0.0067 0.0135
Leishmania major GDP-mannose pyrophosphorylase 0.0036 0.004 0.0906
Brugia malayi sulfakinin receptor protein 0.0056 0.0067 0.1133
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0056 0.0067 0.0135
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0018 0.0015 0.0026
Echinococcus granulosus GPCR family 2 0.0018 0.0015 0.0026
Echinococcus multilocularis neuropeptide receptor 0.0056 0.0067 0.0113
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0056 0.0067 0.1029
Schistosoma mansoni neuropeptide f receptor 76f 0.0056 0.0067 0.0135
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0056 0.0067 0.0135
Brugia malayi larval opioid receptor 0.0056 0.0067 0.1133
Trypanosoma cruzi serine acetyltransferase, putative 0.0035 0.0038 0.0848
Onchocerca volvulus 0.0056 0.0067 0.1029
Echinococcus granulosus smad 0.0009 0.0003 0.0005
Plasmodium falciparum ataxin-2 like protein, putative 0.0029 0.003 0.604
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0056 0.0067 0.0135
Echinococcus multilocularis rhodopsin orphan GPCR 0.0056 0.0067 0.0113
Echinococcus multilocularis mothers against decapentaplegic 5 0.0009 0.0003 0.0005
Brugia malayi neuropeptide F receptor 0.0056 0.0067 0.1133
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0056 0.0067 0.0113
Echinococcus multilocularis glutamate receptor ionotropic kainate 0.0419 0.0567 0.0958
Toxoplasma gondii hypothetical protein 0.0035 0.0038 0.0134
Plasmodium vivax mannose-1-phosphate guanyltransferase, putative 0.0036 0.004 1
Echinococcus granulosus nmda type glutamate receptor 0.4304 0.5919 1
Echinococcus granulosus g-protein coupled receptor 0.0056 0.0067 0.0113
Brugia malayi hypothetical protein 0.0035 0.0038 0.0621
Echinococcus granulosus neuropeptide FF receptor 2 0.0056 0.0067 0.0113
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0056 0.0067 0.0113
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0038 0.0848
Schistosoma mansoni mannose-1-phosphate guanyltransferase 0.0036 0.004 0.0077
Loa Loa (eye worm) melatonin receptor type 1A 0.0056 0.0067 0.1184
Echinococcus granulosus fmrfamide receptor 0.0056 0.0067 0.0113
Echinococcus granulosus 7tm_1 domain containing protein 0.0056 0.0067 0.0113
Loa Loa (eye worm) glutamate receptor 0.0215 0.0286 0.5044
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0056 0.0067 0.0135
Loa Loa (eye worm) neuropeptide F receptor 0.0056 0.0067 0.1184
Loa Loa (eye worm) hypothetical protein 0.0056 0.0067 0.1184
Mycobacterium ulcerans molybdopterin-guanine dinucleotide biosynthesis protein A 0.1262 0.1729 0.1697
Onchocerca volvulus 0.0056 0.0067 0.1029
Echinococcus granulosus glutamate receptor subunit protein glur 0.0419 0.0567 0.0958
Echinococcus multilocularis fmrfamide receptor 0.0056 0.0067 0.0113
Toxoplasma gondii histone lysine methyltransferase SET1 0.0043 0.0049 0.0197
Echinococcus granulosus neuropeptide receptor 0.0056 0.0067 0.0113
Echinococcus granulosus mothers against decapentaplegic 5 0.0009 0.0003 0.0005
Loa Loa (eye worm) hypothetical protein 0.0056 0.0067 0.1184
Schistosoma mansoni opsin-like receptor 0.0056 0.0067 0.0135
Onchocerca volvulus 0.0056 0.0067 0.1029
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0018 0.0015 0.0026
Schistosoma mansoni cpg binding protein 0.0024 0.0023 0.0042
Onchocerca volvulus 0.0056 0.0067 0.1029
Brugia malayi neuropeptide F receptor 0.0056 0.0067 0.1133
Toxoplasma gondii eukaryotic initiation factor-2B, epsilon subunit, putative 0.0035 0.0038 0.0134
Schistosoma mansoni amine GPCR 0.0056 0.0067 0.0135
Echinococcus granulosus tyrosine kinase 0.0215 0.0286 0.0483
Schistosoma mansoni hypothetical protein 0.0018 0.0015 0.0025
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0633 0.0863 0.1457
Brugia malayi hypothetical protein 0.0215 0.0286 0.5016
Echinococcus multilocularis neuropeptides capa receptor 0.0056 0.0067 0.0113
Brugia malayi G protein-coupled receptor 0.0056 0.0067 0.1133
Echinococcus multilocularis neuropeptide Y receptor 0.0056 0.0067 0.0113
Loa Loa (eye worm) hypothetical protein 0.0345 0.0466 0.8222
Loa Loa (eye worm) hypothetical protein 0.0029 0.003 0.0531
Mycobacterium ulcerans d-alpha-D-mannose-1-phosphate guanylyltransferase ManB 0.0036 0.004 0.0002
Echinococcus granulosus biogenic amine 5HT receptor 0.0056 0.0067 0.0113
Schistosoma mansoni cpg binding protein 0.0022 0.0021 0.0038
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0056 0.0067 0.0135
Onchocerca volvulus 0.0056 0.0067 0.1029
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0056 0.0067 0.1133
Schistosoma mansoni hypothetical protein 0.0018 0.0015 0.0025
Brugia malayi Latrophilin receptor protein 2 0.0018 0.0015 0.0213
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0633 0.0863 0.1457
Loa Loa (eye worm) hypothetical protein 0.0056 0.0067 0.1184
Echinococcus granulosus g protein coupled receptor 0.0056 0.0067 0.0113
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0633 0.0863 0.1457
Trypanosoma brucei GDP-mannose pyrophosphorylase 0.0036 0.004 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0056 0.0067 0.0113
Echinococcus granulosus allatostatin A receptor 0.0056 0.0067 0.0113
Trypanosoma cruzi serine acetyltransferase, putative 0.0035 0.0038 0.0848
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0056 0.0067 0.0135
Trichomonas vaginalis glucose-1-phosphate thymidylyltransferase, putative 0.0036 0.004 1
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0056 0.0067 0.0113
Onchocerca volvulus 0.0056 0.0067 0.1029
Toxoplasma gondii LsmAD domain-containing protein 0.0029 0.003 0.0086
Loa Loa (eye worm) hypothetical protein 0.0056 0.0067 0.1184
Loa Loa (eye worm) hypothetical protein 0.0056 0.0067 0.1184
Schistosoma mansoni biogenic amine (5HT) receptor 0.0056 0.0067 0.0135
Brugia malayi metabotropic glutamate receptor type 2 0.0215 0.0286 0.5016
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0013 0.0008 0.0014
Mycobacterium tuberculosis Probable serine acetyltransferase CysE (sat) 0.0035 0.0038 0.0023
Loa Loa (eye worm) latrophilin receptor protein 2 0.0018 0.0015 0.0269
Brugia malayi hypothetical protein 0.0035 0.0038 0.0621
Brugia malayi Serotonin receptor 0.0056 0.0067 0.1133
Echinococcus granulosus rhodopsin orphan GPCR 0.0056 0.0067 0.0113
Schistosoma mansoni gdp-mannose pyrophosphorylase b isoform 2 0.0036 0.004 0.0077
Schistosoma mansoni neuropeptide receptor 0.0056 0.0067 0.0135
Echinococcus multilocularis metabotropic glutamate receptor 2 0.0215 0.0286 0.0483
Echinococcus granulosus tm gpcr rhodopsin 0.0056 0.0067 0.0113
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0018 0.0015 0.0026
Brugia malayi Glutamate receptor 2 precursor 0.0419 0.0567 1
Loa Loa (eye worm) MH2 domain-containing protein 0.0009 0.0003 0.0057
Echinococcus multilocularis neuropeptide FF receptor 2 0.0056 0.0067 0.0113
Echinococcus multilocularis neuropeptide receptor A26 0.0056 0.0067 0.0113
Echinococcus granulosus dnaJ subfamily B 0.032 0.0431 0.0728
Plasmodium vivax ataxin-2 like protein, putative 0.0029 0.003 0.604
Echinococcus multilocularis GPCR, family 2 0.0018 0.0015 0.0026
Loa Loa (eye worm) RGC/RGC protein kinase 0.0215 0.0286 0.5044
Loa Loa (eye worm) hypothetical protein 0.0056 0.0067 0.1184
Loa Loa (eye worm) hypothetical protein 0.0056 0.0067 0.1184
Brugia malayi putative neuropeptide receptor 0.0056 0.0067 0.1133
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0056 0.0067 0.0135
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0009 0.0003 0.0005
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0018 0.0015 0.0213
Echinococcus granulosus geminin 0.0194 0.0257 0.0434
Brugia malayi AKH receptor 0.0056 0.0067 0.1133
Echinococcus multilocularis mannose 1 phosphate guanyltransferase beta 0.0035 0.0038 0.0065
Toxoplasma gondii eukaryotic initiation factor 2B epsilon subunit, putative 0.0035 0.0038 0.0134
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0013 0.0008 0.0014
Echinococcus granulosus metabotropic glutamate receptor 5 0.0215 0.0286 0.0483
Schistosoma mansoni biogenic amine receptor 0.0056 0.0067 0.0135
Schistosoma mansoni dynactin subunit P25 0.0035 0.0038 0.0074
Loa Loa (eye worm) hypothetical protein 0.0056 0.0067 0.1184
Echinococcus multilocularis sex peptide receptor 0.0056 0.0067 0.0113
Brugia malayi G-protein coupled receptor 0.0056 0.0067 0.1133
Schistosoma mansoni glutamate receptor kainate 0.0419 0.0567 0.1191
Echinococcus granulosus dro:myosuppressin receptor 0.0056 0.0067 0.0113
Schistosoma mansoni neuropeptide F-like receptor 0.0056 0.0067 0.0135
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0018 0.0015 0.0026
Echinococcus multilocularis rhodopsin orphan GPCR 0.0056 0.0067 0.0113
Toxoplasma gondii eukaryotic initiation factor-2B, gamma subunit, putative 0.1262 0.1729 1
Loa Loa (eye worm) hypothetical protein 0.0056 0.0067 0.1184
Loa Loa (eye worm) GDP-mannose pyrophosphorylase B 0.0035 0.0038 0.0675
Echinococcus granulosus neuropeptide Y receptor 0.0056 0.0067 0.0113
Loa Loa (eye worm) hypothetical protein 0.0056 0.0067 0.1184
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0056 0.0067 0.1184
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0056 0.0067 0.0135
Onchocerca volvulus 0.0056 0.0067 0.1029
Echinococcus granulosus rhodopsin orphan GPCR 0.0056 0.0067 0.0113
Echinococcus multilocularis glutamate receptor, ionotrophic, AMPA 3 0.0633 0.0863 0.1457
Echinococcus multilocularis g protein coupled receptor 0.0056 0.0067 0.0113
Loa Loa (eye worm) dynactin 5 0.0035 0.0038 0.0675
Echinococcus granulosus mannose 1 phosphate guanyltransferase beta 0.0035 0.0038 0.0065
Leishmania major hypothetical protein, conserved 0.0035 0.0038 0.0848
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0056 0.0067 0.0135
Wolbachia endosymbiont of Brugia malayi N-acetylglucosamine-1-phosphate uridyltransferase 0.7267 1 1
Echinococcus granulosus rhodopsin orphan GPCR 0.0056 0.0067 0.0113
Brugia malayi hypothetical protein 0.0056 0.0067 0.1133
Trypanosoma cruzi hypothetical protein 0.0035 0.0038 0.0848
Echinococcus multilocularis nmda type glutamate receptor 0.4304 0.5919 1
Schistosoma mansoni glutamate receptor AMPA 0.0419 0.0567 0.1191
Brugia malayi Receptor family ligand binding region containing protein 0.0215 0.0286 0.5016
Schistosoma mansoni glutamate receptor AMPA 0.0419 0.0567 0.1191
Schistosoma mansoni hypothetical protein 0.0056 0.0067 0.0135
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0633 0.0863 0.1457
Brugia malayi Dopamine receptor 0.0056 0.0067 0.1133
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0057 0.0069 0.1165
Echinococcus multilocularis rhodopsin orphan GPCR 0.0056 0.0067 0.0113
Echinococcus granulosus mannose 1 phosphate guanyltransferase 0.0036 0.004 0.0067
Echinococcus multilocularis glutamate receptor 2 0.0215 0.0286 0.0483
Mycobacterium tuberculosis Probable glutamine-binding lipoprotein GlnH (GLNBP) 0.1073 0.1468 0.1455
Brugia malayi hypothetical protein 0.0056 0.0067 0.1133
Brugia malayi hypothetical protein 0.0029 0.003 0.0477

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.