TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 430.41 | Formula: C24H18N2O6
H donors: 1 H acceptors: 5 LogP: 4.35 Rotable bonds: 6
Rule of 5 violations (Lipinski): 1
SMILES: COc1cccc(c1)N1C(c2ccc(cc2)[N+](=O)[O-])C(=C(C1=O)O)C(=O)c1ccccc1
InChi: 1S/C24H18N2O6/c1-32-19-9-5-8-18(14-19)25-21(15-10-12-17(13-11-15)26(30)31)20(23(28)24(25)29)22(27)16-6-3-2-4-7-16/h2-14,21,28H,1H3
InChiKey: RCKXTXRCSJCFEA-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Mycobacterium tuberculosis	Peptide synthetase MbtE (peptide synthase)	0.0022	0.0132	0.0557
Mycobacterium ulcerans	acyl-CoA synthetase	0.0022	0.0132	0.0557
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0286	0.1839
Onchocerca volvulus	Casein kinase II subunit beta homolog	0.0071	0.0768	0.9638
Echinococcus granulosus	laminin	0.0014	0.0029	0.022
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0029	0.0112
Trypanosoma cruzi	Casein kinase II subunit beta, putative	0.0071	0.0768	1
Leishmania major	hypothetical protein, conserved	0.0052	0.0521	0.6491
Leishmania major	acetyl-CoA synthetase, putative	0.0022	0.0132	0.1528
Plasmodium falciparum	enoyl-acyl carrier reductase	0.0181	0.2164	1
Trypanosoma brucei	phosphoinositide-specific phospholipase C	0.0019	0.0095	0.1091
Schistosoma mansoni	acetyl-CoA synthetase	0.0022	0.0132	0.1722
Echinococcus granulosus	acetyl coenzyme A synthetase cytoplasmic	0.0022	0.0132	0.1586
Loa Loa (eye worm)	hypothetical protein	0.0074	0.0797	0.5265
Onchocerca volvulus		0.0074	0.0797	1
Entamoeba histolytica	casein kinase II regulatory subunit family protein	0.0021	0.0123	0.1404
Trypanosoma cruzi	hypothetical protein, conserved	0.0052	0.0521	0.6735
Toxoplasma gondii	Acetyl-coenzyme A synthetase 2, putative	0.0022	0.0132	0.0311
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0074	0.0797	0.3644
Mycobacterium ulcerans	long-chain fatty-acid CoA ligase	0.0074	0.0797	0.3644
Brugia malayi	AMP-binding enzyme family protein	0.0022	0.0132	0.0881
Brugia malayi	Trypsin family protein	0.0014	0.0034	0.0225
Mycobacterium ulcerans	O-succinylbenzoic acid--CoA ligase	0.0022	0.0132	0.0557
Brugia malayi	AMP-binding enzyme family protein	0.0074	0.0797	0.5304
Schistosoma mansoni	cercarial elastase (S01 family)	0.0014	0.0034	0.0439
Leishmania major	acetyl-CoA synthetase, putative	0.0022	0.0132	0.1528
Echinococcus multilocularis	acetyl coenzyme A synthetase, cytoplasmic	0.0022	0.0132	0.012
Toxoplasma gondii	PAN domain-containing protein	0.0034	0.0286	0.0712
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0286	0.1839
Leishmania major	phosphatidylinositol-specific phospholipase-like protein	0.0018	0.0081	0.0878
Mycobacterium tuberculosis	Fatty-acid-CoA synthetase FadD17 (fatty-acid-CoA synthase) (fatty-acid-CoA ligase)	0.0022	0.0132	0.0557
Loa Loa (eye worm)	PAN domain-containing protein	0.0034	0.0286	0.1839
Brugia malayi	Trypsin family protein	0.0014	0.0034	0.0225
Mycobacterium leprae	POSSIBLE FATTY-ACID-CoA LIGASE FADD10 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE)	0.0022	0.0132	0.0557
Schistosoma mansoni	cercarial elastase (S01 family)	0.0014	0.0034	0.0439
Echinococcus multilocularis	Mastin	0.0014	0.0034	0.0021
Toxoplasma gondii	enoyl-acyl carrier reductase ENR	0.0181	0.2164	0.5592
Trypanosoma cruzi	Casein kinase II subunit beta, putative	0.0071	0.0768	1
Brugia malayi	Phosphatidylinositol-specific phospholipase C, X domain containing protein	0.0018	0.0081	0.0541
Onchocerca volvulus		0.0052	0.0521	0.6491
Onchocerca volvulus	Casein kinase II subunit beta homolog	0.0071	0.0768	0.9638
Onchocerca volvulus		0.0019	0.0095	0.1051
Brugia malayi	PAN domain containing protein	0.0034	0.0286	0.1907
Echinococcus multilocularis	glycoprotein Antigen 5	0.0014	0.0034	0.0021
Mycobacterium ulcerans	acyl-CoA synthetase	0.0022	0.0132	0.0557
Schistosoma mansoni	cercarial elastase (S01 family)	0.0014	0.0034	0.0439
Echinococcus multilocularis	Peptidase S1 S6, chymotrypsin Hap	0.0014	0.0034	0.0021
Loa Loa (eye worm)	AMP-binding enzyme family protein	0.0022	0.0132	0.0805
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0034	0.0143
Echinococcus granulosus	1-Phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta-4	0.0019	0.0095	0.1091
Schistosoma mansoni	cercarial elastase (S01 family)	0.0014	0.0034	0.0439
Echinococcus multilocularis	1 phosphatidylinositol 4,5 bisphosphate	0.0019	0.0095	0.0083
Onchocerca volvulus		0.0034	0.0286	0.3493
Brugia malayi	Low-density lipoprotein receptor repeat class B containing protein	0.0014	0.0029	0.0193
Toxoplasma gondii	microneme protein MIC17A	0.0034	0.0286	0.0712
Chlamydia trachomatis	acylglycerophosphoethanolamine acyltransferase	0.0055	0.0559	0.254
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0286	0.1839
Toxoplasma gondii	microneme protein MIC17B	0.0034	0.0286	0.0712
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0052	0.052	0.2361
Mycobacterium ulcerans	acyl-CoA synthetase	0.0074	0.0797	0.3644
Schistosoma mansoni	subfamily S1A unassigned peptidase (S01 family)	0.0014	0.0034	0.0439
Trichomonas vaginalis	casein kinase II beta chain, putative	0.0071	0.0768	0.3163
Mycobacterium ulcerans	fatty-acid-CoA ligase	0.0055	0.0559	0.254
Brugia malayi	oxidoreductase, short chain dehydrogenase/reductase family protein	0.0012	0.0012	0.0083
Trypanosoma brucei	long-chain-fatty-acid-CoA ligase, putative	0.0022	0.0132	0.1586
Trichomonas vaginalis	casein kinase II beta chain, putative	0.0071	0.0768	0.3163
Brugia malayi	hypothetical protein	0.0014	0.0034	0.0225
Entamoeba histolytica	acyl-CoA synthetase, putative	0.0074	0.0797	1
Toxoplasma gondii	propionate-CoA ligase	0.0022	0.0132	0.0311
Brugia malayi	casein kinase II, putaitve	0.0021	0.0123	0.0816
Mycobacterium ulcerans	acyl-CoA synthetase	0.0022	0.0132	0.0557
Trichomonas vaginalis	casein kinase II beta chain, putative	0.0071	0.0768	0.3163
Schistosoma mansoni	subfamily S1A unassigned peptidase (S01 family)	0.0014	0.0034	0.0439
Schistosoma mansoni	cercarial elastase (S01 family)	0.0014	0.0034	0.0439
Onchocerca volvulus		0.0014	0.0034	0.0272
Onchocerca volvulus		0.0034	0.0286	0.3493
Echinococcus multilocularis	Tolloid protein 1	0.0014	0.0029	0.0017
Echinococcus multilocularis	casein kinase ii subunit beta	0.0071	0.0768	0.0757
Onchocerca volvulus		0.0034	0.0286	0.3493
Mycobacterium leprae	PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE)	0.0074	0.0797	0.3644
Mycobacterium leprae	NADH-DEPENDENT ENOYL-[ACYL-CARRIER-PROTEIN] REDUCTASE INHA (NADH-DEPENDENT ENOYL-ACP REDUCTASE)	0.0181	0.2164	1
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0286	0.1839
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0132	0.0805
Toxoplasma gondii	1,3(4)-beta-glucanase	0.0034	0.0286	0.0712
Mycobacterium ulcerans	bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ACP synthetase	0.0022	0.0132	0.0557
Loa Loa (eye worm)	hypothetical protein	0.0055	0.0559	0.3669
Mycobacterium ulcerans	non-ribosomal peptide synthetase MbtE	0.0022	0.0132	0.0557
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0286	0.1839
Loa Loa (eye worm)	Csnk2b protein	0.0071	0.0768	0.5074
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0034	0.0143
Trichomonas vaginalis	casein kinase II beta chain, putative	0.0071	0.0768	0.3163
Brugia malayi	AMP-binding enzyme family protein	0.0022	0.0132	0.0881
Echinococcus granulosus	subfamily S1A unassigned peptidase S01 family	0.0014	0.0034	0.0282
Loa Loa (eye worm)	hypothetical protein	0.0055	0.0559	0.3669
Onchocerca volvulus		0.0034	0.0286	0.3493
Brugia malayi	AMP-binding enzyme family protein	0.0022	0.0132	0.0881
Plasmodium falciparum	casein kinase II beta chain	0.0071	0.0768	0.3513
Schistosoma mansoni	subfamily S1A unassigned peptidase (S01 family)	0.0014	0.0034	0.0439
Entamoeba histolytica	acyl-coA synthetase, putative	0.0074	0.0797	1
Toxoplasma gondii	calcium binding egf domain-containing protein	0.0014	0.0029	0.0043
Mycobacterium ulcerans	acyl-CoA synthetase	0.0022	0.0132	0.0557
Mycobacterium tuberculosis	Phenyloxazoline synthase MbtB (phenyloxazoline synthetase)	0.0022	0.0132	0.0557
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0022	0.0132	0.0557
Onchocerca volvulus		0.0014	0.0034	0.0272
Schistosoma mansoni	cercarial elastase (S01 family)	0.0014	0.0034	0.0439
Mycobacterium ulcerans	enoyl-(acyl carrier protein) reductase	0.0181	0.2164	1
Plasmodium vivax	casein kinase II beta chain, putative	0.0071	0.0768	0.3513
Brugia malayi	PAN domain containing protein	0.0034	0.0286	0.1907
Onchocerca volvulus		0.0014	0.0034	0.0272
Plasmodium vivax	enoyl-acyl carrier protein reductase	0.0181	0.2164	1
Echinococcus granulosus	enteropeptidase	0.0014	0.0034	0.0282
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0034	0.0143
Toxoplasma gondii	PAN domain-containing protein	0.0314	0.386	1
Plasmodium falciparum	acetyl-CoA synthetase, putative	0.0022	0.0132	0.0557
Mycobacterium ulcerans	hypothetical protein	0.0014	0.0034	0.0099
Schistosoma mansoni	phospholipase C beta	0.0018	0.0081	0.1058
Brugia malayi	PAN domain containing protein	0.0034	0.0286	0.1907
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0029	0.0112
Brugia malayi	PAN domain containing protein	0.0034	0.0286	0.1907
Leishmania major	4-coumarate:coa ligase-like protein	0.0074	0.0797	1
Brugia malayi	PAN domain containing protein	0.0034	0.0286	0.1907
Mycobacterium tuberculosis	Possible fatty-acid-CoA ligase FadD1 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0022	0.0132	0.0557
Toxoplasma gondii	casein kinase ii regulatory subunit protein	0.0071	0.0768	0.1964
Mycobacterium leprae	PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE)	0.0074	0.0797	0.3644
Trichomonas vaginalis	casein kinase II beta chain, putative	0.0071	0.0768	0.3163
Mycobacterium ulcerans	long-chain-fatty-acid--CoA ligase	0.0074	0.0797	0.3644
Mycobacterium ulcerans	peptide synthetase Nrp (peptide synthase)	0.0022	0.0132	0.0557
Schistosoma mansoni	subfamily S1A unassigned peptidase (S01 family)	0.0014	0.0034	0.0439
Entamoeba histolytica	casein kinase II regulatory subunit family protein	0.0071	0.0768	0.9638
Trichomonas vaginalis	casein kinase II beta chain, putative	0.0071	0.0768	0.3163
Onchocerca volvulus		0.0034	0.0286	0.3493
Loa Loa (eye worm)	Plcb4 protein	0.0018	0.0081	0.0462
Echinococcus multilocularis	transmembrane protease serine 3	0.0014	0.0034	0.0021
Onchocerca volvulus		0.0034	0.0286	0.3493
Toxoplasma gondii	kringle domain-containing protein	0.0052	0.0521	0.1323
Mycobacterium leprae	POSSIBLE O-SUCCINYLBENZOIC ACID--CoA LIGASE MENE (OSB-CoA SYNTHETASE) (O-SUCCINYLBENZOATE-CoA SYNTHASE)	0.0022	0.0132	0.0557
Mycobacterium ulcerans	acyl-CoA synthetase	0.0074	0.0797	0.3644
Loa Loa (eye worm)	hypothetical protein	0.0055	0.0559	0.3669
Mycobacterium ulcerans	acetyl-CoA synthetase	0.0022	0.0132	0.0557
Toxoplasma gondii	PAN domain-containing protein	0.0034	0.0286	0.0712
Brugia malayi	PAN domain containing protein	0.0034	0.0286	0.1907
Mycobacterium tuberculosis	PROBABLE FATTY-ACID-CoA LIGASE FADD18 (FRAGMENT) (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE)	0.0019	0.0094	0.0379
Loa Loa (eye worm)	multiple epidermal growth factor-like domains 6	0.0014	0.0029	0.0112
Mycobacterium tuberculosis	Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase	0.0022	0.0132	0.0557
Brugia malayi	Fibulin-1 precursor	0.0014	0.0029	0.0193
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0029	0.0112
Leishmania major	long-chain-fatty-acid-CoA ligase, putative	0.0022	0.0132	0.1528
Loa Loa (eye worm)	casein kinase II	0.0021	0.0123	0.0739
Loa Loa (eye worm)	hypothetical protein	0.0074	0.0797	0.5265
Toxoplasma gondii	hypothetical protein	0.0034	0.0286	0.0712
Onchocerca volvulus		0.0014	0.0034	0.0272
Schistosoma mansoni	subfamily S1A unassigned peptidase (S01 family)	0.0014	0.0034	0.0439
Wolbachia endosymbiont of Brugia malayi	enoyl-ACP reductase	0.0181	0.2164	1
Loa Loa (eye worm)	phosphatidylinositol-specific phospholipase C	0.0019	0.0095	0.0553
Schistosoma mansoni	3-oxoacyl-[ACP] reductase	0.0012	0.0012	0.0162
Schistosoma mansoni	cercarial elastase (S01 family)	0.0014	0.0034	0.0439
Loa Loa (eye worm)	variant SH3 domain-containing protein	0.0129	0.1502	1
Echinococcus multilocularis	fibrillin 1	0.0014	0.0029	0.0017
Mycobacterium ulcerans	acyl-CoA synthetase	0.0022	0.0132	0.0557
Brugia malayi	PAN domain containing protein	0.0034	0.0286	0.1907
Brugia malayi	PAN domain containing protein	0.0034	0.0286	0.1907
Onchocerca volvulus		0.0022	0.0132	0.1528
Trypanosoma cruzi	acetyl-CoA synthetase, putative	0.0022	0.0132	0.1586
Mycobacterium tuberculosis	Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase)	0.0074	0.0797	0.3644
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0052	0.052	0.2361
Brugia malayi	Trypsin family protein	0.0014	0.0034	0.0225
Brugia malayi	Chymotrypsin-like protease CTRL-1 precursor	0.0014	0.0034	0.0225
Mycobacterium ulcerans	hypothetical protein	0.0074	0.0797	0.3644
Onchocerca volvulus		0.0019	0.0095	0.1051
Mycobacterium leprae	Probable fatty-acid-CoA synthetase FadD22 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase)	0.0022	0.0132	0.0557
Mycobacterium ulcerans	long-chain-acyl-CoA synthetase	0.0022	0.0132	0.0557
Leishmania major	4-coumarate:coa ligase-like protein	0.0074	0.0797	1
Brugia malayi	Csnk2b protein	0.0071	0.0768	0.5115
Schistosoma mansoni	cercarial elastase (S01 family)	0.0014	0.0034	0.0439
Mycobacterium ulcerans	acyl-CoA synthetase	0.0022	0.0132	0.0557
Leishmania major	4-coumarate:coa ligase-like protein	0.0074	0.0797	1
Toxoplasma gondii	microneme protein MIC4	0.0034	0.0286	0.0712
Trichomonas vaginalis	casein kinase II beta chain, putative	0.0071	0.0768	0.3163
Toxoplasma gondii	PAN domain-containing protein	0.0034	0.0286	0.0712
Plasmodium vivax	cysteine repeat modular protein 1, putative	0.0052	0.0521	0.2366
Schistosoma mansoni	cercarial elastase (S01 family)	0.0014	0.0034	0.0439
Plasmodium vivax	acyl-CoA synthetase, putative	0.0055	0.0559	0.254
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0132	0.0805
Schistosoma mansoni	hypothetical protein	0.0052	0.0521	0.6788
Entamoeba histolytica	acyl-CoA synthetase, putative	0.0074	0.0797	1
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0095	0.0553
Echinococcus multilocularis	enteropeptidase	0.0014	0.0034	0.0021
Brugia malayi	Trypsin-like protease protein 5	0.0014	0.0034	0.0225
Toxoplasma gondii	microneme protein, putative	0.0034	0.0286	0.0712
Plasmodium vivax	casein kinase II beta chain, putative	0.0071	0.0768	0.3513
Onchocerca volvulus	Arrow homolog	0.0014	0.0029	0.0212
Entamoeba histolytica	casein kinase II regulatory subunit family protein	0.0071	0.0768	0.9638
Mycobacterium ulcerans	long-chain-fatty-acid--CoA ligase	0.0022	0.0132	0.0557
Toxoplasma gondii	PAN domain-containing protein	0.0314	0.386	1
Echinococcus granulosus	Tolloid protein 1	0.0014	0.0029	0.022
Loa Loa (eye worm)	low-density lipoprotein receptor repeat class B containing protein	0.0014	0.0029	0.0112
Onchocerca volvulus		0.0022	0.0132	0.1528
Onchocerca volvulus		0.0034	0.0286	0.3493
Brugia malayi	Variant SH3 domain containing protein	0.0129	0.1502	1
Schistosoma mansoni	hypothetical protein	0.0014	0.0034	0.0439
Brugia malayi	Calcium binding EGF domain containing protein	0.0014	0.0029	0.0193
Trichomonas vaginalis	casein kinase II beta chain, putative	0.0071	0.0768	0.3163
Toxoplasma gondii	microneme protein MIC17C	0.0034	0.0286	0.0712
Brugia malayi	Kringle domain containing protein	0.0052	0.0521	0.3472
Plasmodium falciparum	phosphoinositide-specific phospholipase C	0.0018	0.0081	0.032
Mycobacterium ulcerans	acyl-CoA synthetase	0.0022	0.0132	0.0557
Toxoplasma gondii	calcium binding egf domain-containing protein	0.0014	0.0029	0.0043
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0034	0.0143
Toxoplasma gondii	phosphoinositide phospholipase PIPLC	0.0019	0.0095	0.0214
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0286	0.1839
Mycobacterium tuberculosis	Possible fatty-acid-CoA ligase FadD10 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0022	0.0132	0.0557
Trypanosoma cruzi	long-chain-fatty-acid-CoA ligase, putative	0.0022	0.0132	0.1586
Schistosoma mansoni	subfamily S1A unassigned peptidase (S01 family)	0.0014	0.0034	0.0439
Entamoeba histolytica	casein kinase II regulatory subunit family protein	0.0021	0.0123	0.1404
Echinococcus granulosus	Peptidase S1 S6 chymotrypsin Hap	0.0014	0.0034	0.0282
Onchocerca volvulus		0.0022	0.0132	0.1528
Plasmodium vivax	acetyl-CoA synthetase, putative	0.0022	0.0132	0.0557
Trypanosoma cruzi	acetyl-CoA synthetase, putative	0.0022	0.0132	0.1586
Loa Loa (eye worm)	hypothetical protein	0.0055	0.0559	0.3669
Schistosoma mansoni	cercarial elastase (S01 family)	0.0014	0.0034	0.0439
Trichomonas vaginalis	casein kinase II beta chain, putative	0.0071	0.0768	0.3163
Toxoplasma gondii	AMP-binding enzyme domain-containing protein	0.0022	0.0132	0.0311
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0029	0.0112
Brugia malayi	Protein kinase domain containing protein	0.0052	0.0521	0.3472
Chlamydia trachomatis	enoyl-acyl-carrier protein reductase	0.0181	0.2164	1
Mycobacterium ulcerans	phenyloxazoline synthase MbtB	0.0022	0.0132	0.0557
Echinococcus granulosus	transmembrane protease serine 3	0.0014	0.0034	0.0282
Mycobacterium ulcerans	fatty-acid-CoA ligase	0.0074	0.0797	0.3644
Onchocerca volvulus		0.0022	0.0132	0.1528
Onchocerca volvulus		0.0034	0.0286	0.3493
Trypanosoma brucei	acetyl-CoA synthetase, putative	0.0022	0.0132	0.1586
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0095	0.0553
Toxoplasma gondii	PAN domain-containing protein	0.0034	0.0286	0.0712
Trichomonas vaginalis	hypothetical protein	0.0181	0.2164	1
Loa Loa (eye worm)	PAN domain-containing protein	0.0034	0.0286	0.1839
Toxoplasma gondii	ck2 beta subunit	0.0071	0.0768	0.1964
Brugia malayi	PAN domain containing protein	0.0034	0.0286	0.1907
Brugia malayi	oxidoreductase, short chain dehydrogenase/reductase family protein	0.0012	0.0012	0.0083
Mycobacterium ulcerans	acyl-CoA synthetase	0.0022	0.0132	0.0557
Trichomonas vaginalis	antibiotic synthetase, putative	0.0022	0.0132	0.0048
Trichomonas vaginalis	casein kinase II beta chain, putative	0.0071	0.0768	0.3163
Loa Loa (eye worm)	TK/ROR protein kinase	0.0052	0.0521	0.3418
Brugia malayi	AMP-binding enzyme family protein	0.0074	0.0797	0.5304
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0034	0.0143
Trichomonas vaginalis	casein kinase II beta chain, putative	0.0071	0.0768	0.3163
Brugia malayi	acetyl-Coenzyme A synthetase 2	0.0022	0.0132	0.0881
Mycobacterium ulcerans	long-chain-fatty-acid-CoA ligase	0.0074	0.0797	0.3644
Trichomonas vaginalis	antibiotic synthetase, putative	0.0022	0.0132	0.0048
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0052	0.052	0.2361
Brugia malayi	Phosphatidylinositol-specific phospholipase C, X domain containing protein	0.0019	0.0095	0.0631
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0034	0.0143
Schistosoma mansoni	subfamily M12A unassigned peptidase (M12 family)	0.0014	0.0029	0.0378
Echinococcus granulosus	casein kinase ii subunit beta	0.0071	0.0768	1
Trichomonas vaginalis	casein kinase II beta chain, putative	0.0071	0.0768	0.3163
Schistosoma mansoni	subfamily S1A unassigned peptidase (S01 family)	0.0014	0.0034	0.0439
Mycobacterium tuberculosis	Probable medium chain fatty-acid-CoA ligase FadD14 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0022	0.0132	0.0557
Brugia malayi	PAN domain containing protein	0.0034	0.0286	0.1907
Loa Loa (eye worm)	PAN domain-containing protein	0.0034	0.0286	0.1839
Entamoeba histolytica	casein kinase II regulatory subunit family protein	0.0071	0.0768	0.9638
Onchocerca volvulus		0.0014	0.0034	0.0272
Echinococcus multilocularis	tissue type plasminogen activator	0.0052	0.0521	0.051
Plasmodium falciparum	casein kinase II beta chain	0.0071	0.0768	0.3513
Echinococcus granulosus	Mastin	0.0014	0.0034	0.0282
Schistosoma mansoni	hypothetical protein	0.0014	0.0034	0.0439
Loa Loa (eye worm)	trypsin family protein	0.0014	0.0034	0.0143
Toxoplasma gondii	subtilisin SUB12	0.0034	0.0286	0.0712
Schistosoma mansoni	dihydropteridine reductase	0.0012	0.0012	0.0162
Loa Loa (eye worm)	bone morphogenetic protein 1b	0.0014	0.0029	0.0112
Schistosoma mansoni	casein kinase II beta subunit	0.0071	0.0768	1
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0034	0.0143
Brugia malayi	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta 4	0.0018	0.0081	0.0541
Brugia malayi	Trypsin family protein	0.0014	0.0034	0.0225
Loa Loa (eye worm)	AMP-binding enzyme family protein	0.0022	0.0132	0.0805
Brugia malayi	AMP-binding enzyme family protein	0.0022	0.0132	0.0881
Onchocerca volvulus		0.0034	0.0286	0.3493
Loa Loa (eye worm)	hypothetical protein	0.0055	0.0559	0.3669
Echinococcus multilocularis	laminin	0.0014	0.0029	0.0017
Trypanosoma brucei	Casein kinase II subunit beta, putative	0.0071	0.0768	1
Plasmodium vivax	phospholipase C-like, putative	0.0018	0.0081	0.032
Leishmania major	protein kinase ck2 regulatory subunit, putative	0.0071	0.0768	0.9638
Mycobacterium tuberculosis	Peptide synthetase MbtF (peptide synthase)	0.0022	0.0132	0.0557
Giardia lamblia	Casein kinase II beta chain	0.0071	0.0768	1
Mycobacterium tuberculosis	Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase)	0.0055	0.0559	0.254
Mycobacterium tuberculosis	NADH-dependent enoyl-[acyl-carrier-protein] reductase InhA (NADH-dependent enoyl-ACP reductase)	0.0181	0.2164	1
Plasmodium falciparum	acyl-CoA synthetase	0.0055	0.0559	0.254
Leishmania major	phosphoinositide-specific phospholipase C, putative	0.0018	0.0081	0.0878
Echinococcus granulosus	tissue type plasminogen activator	0.0052	0.0521	0.6735
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0029	0.0112
Loa Loa (eye worm)	oxidoreductase	0.0022	0.0132	0.0805
Schistosoma mansoni	aminopeptidase PILS (M01 family)	0.0014	0.0034	0.0439
Loa Loa (eye worm)	PAN domain-containing protein	0.0034	0.0286	0.1839
Echinococcus multilocularis	subfamily S1A unassigned peptidase (S01 family)	0.0014	0.0034	0.0021
Onchocerca volvulus		0.0034	0.0286	0.3493
Entamoeba histolytica	long-chain-fatty-acid--CoA ligase, putative	0.0022	0.0132	0.1528
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0081	0.0462
Echinococcus granulosus	glycoprotein Antigen 5	0.0014	0.0034	0.0282
Trypanosoma cruzi	long-chain-fatty-acid-CoA ligase, putative	0.0022	0.0132	0.1586
Loa Loa (eye worm)	hypothetical protein	0.0074	0.0797	0.5265
Brugia malayi	oxidoreductase, short chain dehydrogenase/reductase family protein	0.0022	0.0132	0.0881
Onchocerca volvulus		0.0014	0.0034	0.0272
Brugia malayi	AMP-binding enzyme family protein	0.0074	0.0797	0.5304
Schistosoma mansoni	egf-like domain protein	0.0014	0.0029	0.0378
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0052	0.052	0.2361
Toxoplasma gondii	hypothetical protein	0.0034	0.0286	0.0712
Trichomonas vaginalis	casein kinase II beta chain, putative	0.0071	0.0768	0.3163
Mycobacterium tuberculosis	P-hydroxybenzoyl-AMP ligase FadD22	0.0022	0.0132	0.0557
Trichomonas vaginalis	casein kinase II beta chain, putative	0.0071	0.0768	0.3163
Trypanosoma cruzi	phosphoinositide-specific phospholipase C, putative	0.0019	0.0095	0.1091
Onchocerca volvulus		0.0034	0.0286	0.3493
Loa Loa (eye worm)	PAN domain-containing protein	0.0034	0.0286	0.1839
Toxoplasma gondii	PAN/Apple domain-containing protein	0.0034	0.0286	0.0712
Leishmania major	phospholipase c-like protein	0.0019	0.0095	0.1051
Mycobacterium ulcerans	non-ribosomal peptide synthetase MbtF	0.0022	0.0132	0.0557
Trichomonas vaginalis	casein kinase II beta chain, putative	0.0071	0.0768	0.3163
Schistosoma mansoni	cercarial elastase (S01 family)	0.0014	0.0034	0.0439
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0286	0.1839
Plasmodium falciparum	cysteine repeat modular protein 1	0.0052	0.0521	0.2366
Mycobacterium ulcerans	acyl-CoA synthetase	0.0074	0.0797	0.3644
Loa Loa (eye worm)	hypothetical protein	0.0052	0.0521	0.3418
Mycobacterium tuberculosis	Probable peptide synthetase Nrp (peptide synthase)	0.0022	0.0132	0.0557

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

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Bibliographic References

No literature references available for this target.

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Detailed information for compound 797461