Detailed information for compound 797504

Basic information

Technical information
  • TDR Targets ID: 797504
  • Name: 9-ethyl-8-(N-hydroxy-C-methylcarbonimidoyl)-4 -methylfuro[2,3-h]chromen-2-one
  • MW: 285.295 | Formula: C16H15NO4
  • H donors: 1 H acceptors: 2 LogP: 3.3 Rotable bonds: 2
    Rule of 5 violations (Lipinski): 1
  • SMILES: O/N=C(/c1oc2c(c1CC)c1oc(=O)cc(c1cc2)C)\C
  • InChi: 1S/C16H15NO4/c1-4-10-14-12(20-15(10)9(3)17-19)6-5-11-8(2)7-13(18)21-16(11)14/h5-7,19H,4H2,1-3H3/b17-9+
  • InChiKey: XYHGWEFNDYOXSY-RQZCQDPDSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 9-ethyl-8-(N-hydroxy-C-methyl-carbonimidoyl)-4-methyl-furo[2,3-h]chromen-2-one
  • 9-ethyl-8-[(1E)-1-hydroxyiminoethyl]-4-methyl-2-furo[2,3-h]chromenone
  • 9-ethyl-8-(1-hydroxyiminoethyl)-4-methyl-2-furo[2,3-h]chromenone
  • 8-acetohydroximoyl-9-ethyl-4-methyl-furo[5,4-h]chromen-2-one
  • Oprea1_200248
  • ChemDiv1_026251

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trichomonas vaginalis casein kinase II beta chain, putative 0.0021 0.0122 0.0426
Trypanosoma brucei long-chain-fatty-acid-CoA ligase, putative 0.0014 0.0031 0.0254
Schistosoma mansoni cercarial elastase (S01 family) 0.0014 0.0033 0.0439
Mycobacterium ulcerans acyl-CoA synthetase 0.0014 0.0031 0.0089
Brugia malayi PAN domain containing protein 0.0033 0.0284 0.1907
Mycobacterium ulcerans hypothetical protein 0.0046 0.045 0.2051
Loa Loa (eye worm) hypothetical protein 0.0035 0.03 0.195
Mycobacterium tuberculosis Possible oxidoreductase 0.0012 0.0012 0.0024
Brugia malayi hypothetical protein 0.0014 0.0033 0.0225
Mycobacterium ulcerans acetyl-CoA synthetase 0.0014 0.0031 0.0089
Brugia malayi AMP-binding enzyme family protein 0.0014 0.0031 0.0211
Mycobacterium tuberculosis Probable dehydrogenase/reductase 0.0012 0.0012 0.0024
Schistosoma mansoni cercarial elastase (S01 family) 0.0014 0.0033 0.0439
Trichomonas vaginalis casein kinase II beta chain, putative 0.0021 0.0122 0.0426
Trichomonas vaginalis casein kinase II beta chain, putative 0.0071 0.0762 0.3454
Loa Loa (eye worm) hypothetical protein 0.0035 0.03 0.195
Mycobacterium tuberculosis Probable oxidoreductase 0.0012 0.0012 0.0024
Loa Loa (eye worm) hypothetical protein 0.0033 0.0284 0.1839
Brugia malayi Fibulin-1 precursor 0.0013 0.0029 0.0193
Toxoplasma gondii microneme protein MIC17C 0.0033 0.0284 0.0712
Loa Loa (eye worm) hypothetical protein 0.0046 0.045 0.2965
Onchocerca volvulus 0.0033 0.0284 0.3623
Mycobacterium ulcerans acyl-CoA synthetase 0.0014 0.0031 0.0089
Brugia malayi PAN domain containing protein 0.0033 0.0284 0.1907
Schistosoma mansoni acetyl-CoA synthetase 0.0014 0.0031 0.0412
Leishmania major phospholipase c-like protein 0.0019 0.0094 0.1089
Echinococcus granulosus Tolloid protein 1 0.0013 0.0029 0.0219
Plasmodium falciparum casein kinase II beta chain 0.0071 0.0762 0.3512
Schistosoma mansoni phospholipase C beta 0.0018 0.0081 0.1058
Loa Loa (eye worm) trypsin family protein 0.0014 0.0033 0.0143
Trypanosoma cruzi Casein kinase II subunit beta, putative 0.0071 0.0762 1
Giardia lamblia Casein kinase II beta chain 0.0071 0.0762 1
Loa Loa (eye worm) hypothetical protein 0.0018 0.0081 0.0462
Echinococcus granulosus transmembrane protease serine 3 0.0014 0.0033 0.0281
Echinococcus granulosus laminin 0.0013 0.0029 0.0219
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0046 0.045 0.2071
Brugia malayi Calcium binding EGF domain containing protein 0.0013 0.0029 0.0193
Toxoplasma gondii kringle domain-containing protein 0.0052 0.0517 0.1323
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0012 0.0012 0.0024
Mycobacterium ulcerans bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ACP synthetase 0.0014 0.0031 0.0089
Plasmodium falciparum enoyl-acyl carrier reductase 0.0179 0.2147 1
Leishmania major 4-coumarate:coa ligase-like protein 0.0046 0.045 0.5841
Loa Loa (eye worm) hypothetical protein 0.0014 0.0033 0.0143
Loa Loa (eye worm) hypothetical protein 0.0013 0.0029 0.0111
Echinococcus multilocularis Peptidase S1 S6, chymotrypsin Hap 0.0014 0.0033 0.0021
Loa Loa (eye worm) hypothetical protein 0.0035 0.03 0.195
Toxoplasma gondii phosphoinositide phospholipase PIPLC 0.0019 0.0094 0.0214
Loa Loa (eye worm) hypothetical protein 0.0033 0.0284 0.1839
Brugia malayi Phosphatidylinositol-specific phospholipase C, X domain containing protein 0.0018 0.0081 0.0541
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0046 0.045 0.2051
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0035 0.03 0.1349
Onchocerca volvulus 0.0014 0.0033 0.0281
Trichomonas vaginalis casein kinase II beta chain, putative 0.0071 0.0762 0.3454
Trichomonas vaginalis casein kinase II beta chain, putative 0.0071 0.0762 0.3454
Mycobacterium ulcerans acyl-CoA synthetase 0.0014 0.0031 0.0089
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0014 0.0031 0.0113
Mycobacterium tuberculosis Possible 20-beta-hydroxysteroid dehydrogenase FabG3 (cortisone reductase) ((R)-20-hydroxysteroid dehydrogenase) 0.0012 0.0012 0.0024
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0033 0.0276 0.1257
Trichomonas vaginalis casein kinase II beta chain, putative 0.0021 0.0122 0.0426
Mycobacterium ulcerans hypothetical protein 0.0014 0.0033 0.0099
Loa Loa (eye worm) hypothetical protein 0.0014 0.0033 0.0143
Entamoeba histolytica casein kinase II regulatory subunit family protein 0.0071 0.0762 1
Trichomonas vaginalis casein kinase II beta chain, putative 0.0021 0.0122 0.0426
Trichomonas vaginalis casein kinase II beta chain, putative 0.0071 0.0762 0.3454
Plasmodium falciparum acetyl-CoA synthetase, putative 0.0014 0.0031 0.0089
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0014 0.0031 0.0254
Plasmodium vivax phospholipase C-like, putative 0.0018 0.0081 0.032
Trichomonas vaginalis casein kinase II beta chain, putative 0.0071 0.0762 0.3454
Mycobacterium ulcerans long-chain-acyl-CoA synthetase 0.0014 0.0031 0.0089
Mycobacterium ulcerans enoyl-(acyl carrier protein) reductase 0.0179 0.2147 1
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0046 0.045 0.2051
Loa Loa (eye worm) multiple epidermal growth factor-like domains 6 0.0013 0.0029 0.0111
Onchocerca volvulus 0.0014 0.0033 0.0281
Loa Loa (eye worm) hypothetical protein 0.0033 0.0284 0.1839
Brugia malayi Trypsin family protein 0.0014 0.0033 0.0225
Schistosoma mansoni cercarial elastase (S01 family) 0.0014 0.0033 0.0439
Loa Loa (eye worm) hypothetical protein 0.0033 0.0284 0.1839
Onchocerca volvulus 0.0014 0.0031 0.0254
Schistosoma mansoni cercarial elastase (S01 family) 0.0014 0.0033 0.0439
Mycobacterium ulcerans acyl-CoA synthetase 0.0014 0.0031 0.0089
Trichomonas vaginalis casein kinase II beta chain, putative 0.0071 0.0762 0.3454
Onchocerca volvulus 0.0052 0.0517 0.6733
Onchocerca volvulus 0.0033 0.0284 0.3623
Brugia malayi PAN domain containing protein 0.0033 0.0284 0.1907
Schistosoma mansoni casein kinase II beta subunit 0.0071 0.0762 1
Onchocerca volvulus 0.0033 0.0284 0.3623
Echinococcus granulosus Peptidase S1 S6 chymotrypsin Hap 0.0014 0.0033 0.0281
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0014 0.0031 0.0211
Schistosoma mansoni hypothetical protein 0.0014 0.0033 0.0439
Toxoplasma gondii PAN domain-containing protein 0.0311 0.3829 1
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtE 0.0014 0.0031 0.0089
Echinococcus granulosus enteropeptidase 0.0014 0.0033 0.0281
Brugia malayi PAN domain containing protein 0.0033 0.0284 0.1907
Brugia malayi Trypsin family protein 0.0014 0.0033 0.0225
Onchocerca volvulus 0.0033 0.0284 0.3623
Plasmodium vivax cysteine repeat modular protein 1, putative 0.0052 0.0517 0.2365
Schistosoma mansoni cercarial elastase (S01 family) 0.0014 0.0033 0.0439
Brugia malayi AMP-binding enzyme family protein 0.0014 0.0031 0.0211
Loa Loa (eye worm) TK/ROR protein kinase 0.0052 0.0517 0.3417
Brugia malayi AMP-binding enzyme family protein 0.0046 0.045 0.3023
Trichomonas vaginalis casein kinase II beta chain, putative 0.0021 0.0122 0.0426
Entamoeba histolytica casein kinase II regulatory subunit family protein 0.0071 0.0762 1
Brugia malayi Trypsin-like protease protein 5 0.0014 0.0033 0.0225
Onchocerca volvulus 0.0014 0.0033 0.0281
Onchocerca volvulus 0.0033 0.0284 0.3623
Onchocerca volvulus 0.0014 0.0031 0.0254
Loa Loa (eye worm) PAN domain-containing protein 0.0033 0.0284 0.1839
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0046 0.045 0.2071
Loa Loa (eye worm) hypothetical protein 0.0019 0.0094 0.0553
Brugia malayi AMP-binding enzyme family protein 0.0046 0.045 0.3023
Plasmodium vivax casein kinase II beta chain, putative 0.0071 0.0762 0.3512
Loa Loa (eye worm) Plcb4 protein 0.0018 0.0081 0.0462
Toxoplasma gondii microneme protein MIC4 0.0033 0.0284 0.0712
Leishmania major long-chain-fatty-acid-CoA ligase, putative 0.0014 0.0031 0.0254
Toxoplasma gondii ck2 beta subunit 0.0071 0.0762 0.1965
Schistosoma mansoni dihydropteridine reductase 0.0012 0.0012 0.0162
Brugia malayi AMP-binding enzyme family protein 0.0014 0.0031 0.0211
Mycobacterium ulcerans peptide synthetase Nrp (peptide synthase) 0.0014 0.0031 0.0089
Onchocerca volvulus 0.0014 0.0031 0.0254
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative 0.0014 0.0031 0.0254
Onchocerca volvulus 0.0033 0.0284 0.3623
Onchocerca volvulus Casein kinase II subunit beta homolog 0.0071 0.0762 1
Brugia malayi Csnk2b protein 0.0071 0.0762 0.5117
Schistosoma mansoni cercarial elastase (S01 family) 0.0014 0.0033 0.0439
Leishmania major acetyl-CoA synthetase, putative 0.0014 0.0031 0.0254
Toxoplasma gondii microneme protein, putative 0.0033 0.0284 0.0712
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD22 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) 0.0014 0.0031 0.0089
Toxoplasma gondii AMP-binding enzyme domain-containing protein 0.0014 0.0031 0.005
Trypanosoma cruzi hypothetical protein, conserved 0.0052 0.0517 0.6733
Loa Loa (eye worm) hypothetical protein 0.0046 0.045 0.2965
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0014 0.0031 0.0254
Loa Loa (eye worm) hypothetical protein 0.0014 0.0031 0.0129
Onchocerca volvulus Casein kinase II subunit beta homolog 0.0071 0.0762 1
Onchocerca volvulus 0.0033 0.0284 0.3623
Echinococcus multilocularis 1 phosphatidylinositol 4,5 bisphosphate 0.0019 0.0094 0.0082
Trichomonas vaginalis casein kinase II beta chain, putative 0.0021 0.0122 0.0426
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0046 0.045 0.2051
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0033 0.0276 0.1257
Onchocerca volvulus 0.0033 0.0284 0.3623
Mycobacterium leprae NADH-DEPENDENT ENOYL-[ACYL-CARRIER-PROTEIN] REDUCTASE INHA (NADH-DEPENDENT ENOYL-ACP REDUCTASE) 0.0179 0.2147 1
Trichomonas vaginalis casein kinase II beta chain, putative 0.0021 0.0122 0.0426
Trichomonas vaginalis casein kinase II beta chain, putative 0.0021 0.0122 0.0426
Entamoeba histolytica casein kinase II regulatory subunit family protein 0.0021 0.0122 0.1457
Mycobacterium ulcerans acyl-CoA synthetase 0.0014 0.0031 0.0089
Plasmodium vivax acetyl-CoA synthetase, putative 0.0014 0.0031 0.0089
Trichomonas vaginalis casein kinase II beta chain, putative 0.0071 0.0762 0.3454
Echinococcus granulosus Mastin 0.0014 0.0033 0.0281
Plasmodium falciparum cysteine repeat modular protein 1 0.0052 0.0517 0.2365
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0012 0.0012 0.0024
Mycobacterium leprae POSSIBLE FATTY-ACID-CoA LIGASE FADD10 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0014 0.0031 0.0089
Toxoplasma gondii PAN/Apple domain-containing protein 0.0033 0.0284 0.0712
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0014 0.0031 0.0129
Mycobacterium tuberculosis NADH-dependent enoyl-[acyl-carrier-protein] reductase InhA (NADH-dependent enoyl-ACP reductase) 0.0179 0.2147 1
Toxoplasma gondii propionate-CoA ligase 0.0014 0.0031 0.005
Echinococcus granulosus tissue type plasminogen activator 0.0052 0.0517 0.6733
Brugia malayi PAN domain containing protein 0.0033 0.0284 0.1907
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0014 0.0033 0.0439
Trichomonas vaginalis hypothetical protein 0.0179 0.2147 1
Mycobacterium leprae POSSIBLE O-SUCCINYLBENZOIC ACID--CoA LIGASE MENE (OSB-CoA SYNTHETASE) (O-SUCCINYLBENZOATE-CoA SYNTHASE) 0.0014 0.0031 0.0089
Onchocerca volvulus 0.0033 0.0284 0.3623
Mycobacterium tuberculosis Peptide synthetase MbtE (peptide synthase) 0.0014 0.0031 0.0113
Toxoplasma gondii PAN domain-containing protein 0.0311 0.3829 1
Trichomonas vaginalis casein kinase II beta chain, putative 0.0021 0.0122 0.0426
Leishmania major acetyl-CoA synthetase, putative 0.0014 0.0031 0.0254
Plasmodium falciparum casein kinase II beta chain 0.0071 0.0762 0.3512
Trypanosoma brucei phosphoinositide-specific phospholipase C 0.0019 0.0094 0.1089
Schistosoma mansoni hypothetical protein 0.0052 0.0517 0.6786
Toxoplasma gondii 1,3(4)-beta-glucanase 0.0033 0.0284 0.0712
Brugia malayi Chymotrypsin-like protease CTRL-1 precursor 0.0014 0.0033 0.0225
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0012 0.0012 0.0083
Echinococcus granulosus acetyl coenzyme A synthetase cytoplasmic 0.0014 0.0031 0.0254
Echinococcus granulosus subfamily S1A unassigned peptidase S01 family 0.0014 0.0033 0.0281
Schistosoma mansoni cercarial elastase (S01 family) 0.0014 0.0033 0.0439
Echinococcus multilocularis laminin 0.0013 0.0029 0.0016
Onchocerca volvulus 0.0019 0.0094 0.1089
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0012 0.0012 0.0024
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0033 0.0276 0.1257
Loa Loa (eye worm) hypothetical protein 0.0014 0.0033 0.0143
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0046 0.045 0.2051
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0014 0.0033 0.0439
Brugia malayi Variant SH3 domain containing protein 0.0128 0.149 1
Toxoplasma gondii PAN domain-containing protein 0.0033 0.0284 0.0712
Mycobacterium tuberculosis Peptide synthetase MbtF (peptide synthase) 0.0014 0.0031 0.0113
Entamoeba histolytica casein kinase II regulatory subunit family protein 0.0021 0.0122 0.1457
Mycobacterium ulcerans phenyloxazoline synthase MbtB 0.0014 0.0031 0.0089
Loa Loa (eye worm) hypothetical protein 0.0013 0.0029 0.0111
Echinococcus multilocularis Tolloid protein 1 0.0013 0.0029 0.0016
Loa Loa (eye worm) oxidoreductase 0.0014 0.0031 0.0129
Mycobacterium ulcerans acyl-CoA synthetase 0.0014 0.0031 0.0089
Echinococcus multilocularis acetyl coenzyme A synthetase, cytoplasmic 0.0014 0.0031 0.0019
Loa Loa (eye worm) hypothetical protein 0.0014 0.0033 0.0143
Loa Loa (eye worm) PAN domain-containing protein 0.0033 0.0284 0.1839
Chlamydia trachomatis enoyl-acyl-carrier protein reductase 0.0179 0.2147 1
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0014 0.0031 0.0113
Trichomonas vaginalis casein kinase II beta chain, putative 0.0021 0.0122 0.0426
Toxoplasma gondii microneme protein MIC17A 0.0033 0.0284 0.0712
Schistosoma mansoni cercarial elastase (S01 family) 0.0014 0.0033 0.0439
Schistosoma mansoni 3-oxoacyl-[ACP] reductase 0.0012 0.0012 0.0162
Leishmania major phosphatidylinositol-specific phospholipase-like protein 0.0018 0.0081 0.091
Echinococcus granulosus glycoprotein Antigen 5 0.0014 0.0033 0.0281
Mycobacterium ulcerans acyl-CoA synthetase 0.0046 0.045 0.2051
Entamoeba histolytica acyl-CoA synthetase, putative 0.0046 0.045 0.5841
Echinococcus multilocularis glycoprotein Antigen 5 0.0014 0.0033 0.0021
Echinococcus multilocularis Mastin 0.0014 0.0033 0.0021
Brugia malayi Trypsin family protein 0.0014 0.0033 0.0225
Onchocerca volvulus 0.0019 0.0094 0.1089
Brugia malayi PAN domain containing protein 0.0033 0.0284 0.1907
Trichomonas vaginalis casein kinase II beta chain, putative 0.0021 0.0122 0.0426
Toxoplasma gondii hypothetical protein 0.0033 0.0284 0.0712
Loa Loa (eye worm) variant SH3 domain-containing protein 0.0128 0.149 1
Mycobacterium tuberculosis Fatty-acid-CoA synthetase FadD17 (fatty-acid-CoA synthase) (fatty-acid-CoA ligase) 0.0014 0.0031 0.0113
Mycobacterium ulcerans acyl-CoA synthetase 0.0014 0.0031 0.0089
Wolbachia endosymbiont of Brugia malayi enoyl-ACP reductase 0.0179 0.2147 1
Onchocerca volvulus Arrow homolog 0.0013 0.0029 0.0219
Loa Loa (eye worm) hypothetical protein 0.0013 0.0029 0.0111
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0014 0.0031 0.0129
Trypanosoma cruzi Casein kinase II subunit beta, putative 0.0071 0.0762 1
Echinococcus multilocularis enteropeptidase 0.0014 0.0033 0.0021
Brugia malayi Trypsin family protein 0.0014 0.0033 0.0225
Mycobacterium tuberculosis Possible oxidoreductase 0.0012 0.0012 0.0024
Brugia malayi AMP-binding enzyme family protein 0.0014 0.0031 0.0211
Onchocerca volvulus 0.0046 0.045 0.5841
Loa Loa (eye worm) Csnk2b protein 0.0071 0.0762 0.5076
Onchocerca volvulus 0.0014 0.0033 0.0281
Loa Loa (eye worm) hypothetical protein 0.0013 0.0029 0.0111
Toxoplasma gondii PAN domain-containing protein 0.0033 0.0284 0.0712
Trichomonas vaginalis casein kinase II beta chain, putative 0.0071 0.0762 0.3454
Loa Loa (eye worm) phosphatidylinositol-specific phospholipase C 0.0019 0.0094 0.0553
Brugia malayi Low-density lipoprotein receptor repeat class B containing protein 0.0013 0.0029 0.0193
Plasmodium vivax acyl-CoA synthetase, putative 0.0035 0.03 0.1349
Onchocerca volvulus 0.0033 0.0284 0.3623
Brugia malayi Protein kinase domain containing protein 0.0052 0.0517 0.3472
Loa Loa (eye worm) casein kinase II 0.0021 0.0122 0.074
Trichomonas vaginalis casein kinase II beta chain, putative 0.0071 0.0762 0.3454
Trypanosoma brucei Casein kinase II subunit beta, putative 0.0071 0.0762 1
Loa Loa (eye worm) hypothetical protein 0.0013 0.0029 0.0111
Loa Loa (eye worm) bone morphogenetic protein 1b 0.0013 0.0029 0.0111
Echinococcus multilocularis subfamily S1A unassigned peptidase (S01 family) 0.0014 0.0033 0.0021
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0014 0.0033 0.0439
Plasmodium vivax casein kinase II beta chain, putative 0.0071 0.0762 0.3512
Echinococcus granulosus 1-Phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta-4 0.0019 0.0094 0.1089
Loa Loa (eye worm) PAN domain-containing protein 0.0033 0.0284 0.1839
Mycobacterium ulcerans acyl-CoA synthetase 0.0046 0.045 0.2051
Schistosoma mansoni hypothetical protein 0.0014 0.0033 0.0439
Loa Loa (eye worm) hypothetical protein 0.0052 0.0517 0.3417
Echinococcus multilocularis tissue type plasminogen activator 0.0052 0.0517 0.0505
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0014 0.0033 0.0439
Entamoeba histolytica acyl-coA synthetase, putative 0.0046 0.045 0.5841
Schistosoma mansoni cercarial elastase (S01 family) 0.0014 0.0033 0.0439
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0014 0.0033 0.0439
Toxoplasma gondii Acetyl-coenzyme A synthetase 2, putative 0.0014 0.0031 0.005
Onchocerca volvulus 0.0033 0.0284 0.3623
Onchocerca volvulus 0.0014 0.0031 0.0254
Trichomonas vaginalis protein kinase ck2-beta, putative 0.0021 0.0122 0.0426
Brugia malayi acetyl-Coenzyme A synthetase 2 0.0014 0.0031 0.0211
Loa Loa (eye worm) low-density lipoprotein receptor repeat class B containing protein 0.0013 0.0029 0.0111
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0046 0.045 0.2051
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 0.0014 0.0031 0.0113
Brugia malayi Phosphatidylinositol-specific phospholipase C, X domain containing protein 0.0019 0.0094 0.0631
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0035 0.03 0.1349
Mycobacterium tuberculosis Probable medium chain fatty-acid-CoA ligase FadD14 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0014 0.0031 0.0113
Plasmodium vivax enoyl-acyl carrier protein reductase 0.0179 0.2147 1
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0014 0.0033 0.0439
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0046 0.045 0.2051
Plasmodium falciparum phosphoinositide-specific phospholipase C 0.0018 0.0081 0.032
Brugia malayi Kringle domain containing protein 0.0052 0.0517 0.3472
Toxoplasma gondii calcium binding egf domain-containing protein 0.0013 0.0029 0.0043
Loa Loa (eye worm) hypothetical protein 0.0046 0.045 0.2965
Brugia malayi AMP-binding enzyme family protein 0.0046 0.045 0.3023
Trichomonas vaginalis casein kinase II beta chain, putative 0.0071 0.0762 0.3454
Toxoplasma gondii PAN domain-containing protein 0.0033 0.0284 0.0712
Mycobacterium tuberculosis Probable 3-oxoacyl-[acyl-carrier protein] reductase FabG2 (3-ketoacyl-acyl carrier protein reductase) 0.0012 0.0012 0.0024
Schistosoma mansoni aminopeptidase PILS (M01 family) 0.0014 0.0033 0.0439
Trichomonas vaginalis casein kinase II beta chain, putative 0.0071 0.0762 0.3454
Trypanosoma brucei acetyl-CoA synthetase, putative 0.0014 0.0031 0.0254
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) 0.0014 0.0031 0.0113
Entamoeba histolytica casein kinase II regulatory subunit family protein 0.0071 0.0762 1
Brugia malayi 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta 4 0.0018 0.0081 0.0541
Brugia malayi PAN domain containing protein 0.0033 0.0284 0.1907
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0014 0.0033 0.0439
Loa Loa (eye worm) hypothetical protein 0.0033 0.0284 0.1839
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0014 0.0031 0.0254
Schistosoma mansoni cercarial elastase (S01 family) 0.0014 0.0033 0.0439
Loa Loa (eye worm) hypothetical protein 0.0014 0.0033 0.0143
Trichomonas vaginalis casein kinase II beta chain, putative 0.0071 0.0762 0.3454
Loa Loa (eye worm) hypothetical protein 0.0035 0.03 0.195
Trichomonas vaginalis protein kinase ck2-beta, putative 0.0021 0.0122 0.0426
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0035 0.03 0.137
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0012 0.0012 0.0083
Loa Loa (eye worm) hypothetical protein 0.0014 0.0033 0.0143
Loa Loa (eye worm) PAN domain-containing protein 0.0033 0.0284 0.1839
Brugia malayi PAN domain containing protein 0.0033 0.0284 0.1907
Trypanosoma cruzi phosphoinositide-specific phospholipase C, putative 0.0019 0.0094 0.1089
Trichomonas vaginalis casein kinase II beta chain, putative 0.0071 0.0762 0.3454
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtF 0.0014 0.0031 0.0089
Leishmania major protein kinase ck2 regulatory subunit, putative 0.0071 0.0762 1
Onchocerca volvulus 0.0014 0.0033 0.0281
Loa Loa (eye worm) hypothetical protein 0.0033 0.0284 0.1839
Loa Loa (eye worm) hypothetical protein 0.0033 0.0284 0.1839
Mycobacterium ulcerans O-succinylbenzoic acid--CoA ligase 0.0014 0.0031 0.0089
Trichomonas vaginalis casein kinase II beta chain, putative 0.0021 0.0122 0.0426
Loa Loa (eye worm) PAN domain-containing protein 0.0033 0.0284 0.1839
Loa Loa (eye worm) hypothetical protein 0.0019 0.0094 0.0553
Echinococcus multilocularis fibrillin 1 0.0013 0.0029 0.0016
Toxoplasma gondii PAN domain-containing protein 0.0033 0.0284 0.0712
Toxoplasma gondii enoyl-acyl carrier reductase ENR 0.0179 0.2147 0.5594
Leishmania major hypothetical protein, conserved 0.0052 0.0517 0.6733
Toxoplasma gondii subtilisin SUB12 0.0033 0.0284 0.0712
Echinococcus granulosus casein kinase ii subunit beta 0.0071 0.0762 1
Leishmania major phosphoinositide-specific phospholipase C, putative 0.0018 0.0081 0.091
Mycobacterium ulcerans acyl-CoA synthetase 0.0014 0.0031 0.0089
Brugia malayi PAN domain containing protein 0.0033 0.0284 0.1907
Trichomonas vaginalis casein kinase II beta chain, putative 0.0021 0.0122 0.0426
Brugia malayi casein kinase II, putaitve 0.0021 0.0122 0.0817
Loa Loa (eye worm) hypothetical protein 0.0035 0.03 0.195
Toxoplasma gondii casein kinase ii regulatory subunit protein 0.0071 0.0762 0.1965
Echinococcus multilocularis transmembrane protease serine 3 0.0014 0.0033 0.0021
Mycobacterium ulcerans acyl-CoA synthetase 0.0046 0.045 0.2051
Schistosoma mansoni subfamily M12A unassigned peptidase (M12 family) 0.0013 0.0029 0.0378
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0033 0.0276 0.1257
Echinococcus multilocularis casein kinase ii subunit beta 0.0071 0.0762 0.0751
Trichomonas vaginalis casein kinase II beta chain, putative 0.0071 0.0762 0.3454
Schistosoma mansoni cercarial elastase (S01 family) 0.0014 0.0033 0.0439
Leishmania major 4-coumarate:coa ligase-like protein 0.0046 0.045 0.5841
Toxoplasma gondii microneme protein MIC17B 0.0033 0.0284 0.0712
Plasmodium falciparum acyl-CoA synthetase 0.0035 0.03 0.1349
Onchocerca volvulus 0.0014 0.0033 0.0281
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD1 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0014 0.0031 0.0113
Toxoplasma gondii hypothetical protein 0.0033 0.0284 0.0712
Entamoeba histolytica acyl-CoA synthetase, putative 0.0046 0.045 0.5841
Loa Loa (eye worm) hypothetical protein 0.0014 0.0031 0.0129
Trichomonas vaginalis casein kinase II beta chain, putative 0.0071 0.0762 0.3454
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0014 0.0031 0.0254
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0014 0.0031 0.0089
Toxoplasma gondii calcium binding egf domain-containing protein 0.0013 0.0029 0.0043
Brugia malayi PAN domain containing protein 0.0033 0.0284 0.1907
Loa Loa (eye worm) hypothetical protein 0.0014 0.0033 0.0143
Schistosoma mansoni egf-like domain protein 0.0013 0.0029 0.0378
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase 0.0014 0.0031 0.0113
Leishmania major 4-coumarate:coa ligase-like protein 0.0046 0.045 0.5841
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD10 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0014 0.0031 0.0113

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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