TDR Targets

Basic information

Technical information

TDR Targets ID: 797814
Name: 1-(2-ethoxyethoxymethyl)-5-fluoropyrimidine-2 ,4-dione
MW: 232.209 | Formula: C9H13FN2O4
H donors: 1 H acceptors: 2 LogP: -0.31 Rotable bonds: 6
Rule of 5 violations (Lipinski): 1
SMILES: CCOCCOCn1cc(F)c(=O)[nH]c1=O
InChi: 1S/C9H13FN2O4/c1-2-15-3-4-16-6-12-5-7(10)8(13)11-9(12)14/h5H,2-4,6H2,1H3,(H,11,13,14)
InChiKey: XFIOOPVYLWTGIL-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

1-(2-ethoxyethoxymethyl)-5-fluoro-pyrimidine-2,4-dione
1-(2-ethoxyethoxymethyl)-5-fluoro-pyrimidine-2,4-quinone
1H-Pyrimidine-2,4-dione, 1-(2-ethoxyethoxymethyl)-5-fluoro-
ZINC02491971
A3003/0126511
ST4082315

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Brugia malayi	Intermediate filament tail domain containing protein	0.0027	0.0102	0.0076
Loa Loa (eye worm)	hypothetical protein	0.0288	0.1647	0.1645
Toxoplasma gondii	hypothetical protein	0.0288	0.1647	1
Schistosoma mansoni	sodium-dependent neurotransmitter transporter	0.0288	0.1647	0.1645
Echinococcus multilocularis	sodium:chloride dependent neurotransmitter	0.0288	0.1647	0.1632
Onchocerca volvulus		0.0288	0.1647	0.1561
Toxoplasma gondii	Sodium:neurotransmitter symporter family protein	0.0288	0.1647	1
Loa Loa (eye worm)	hypothetical protein	0.0288	0.1647	0.1645
Loa Loa (eye worm)	hypothetical protein	0.0288	0.1647	0.1645
Schistosoma mansoni	sodium/chloride dependent transporter	0.1699	1	1
Echinococcus multilocularis	microtubule associated protein 2	0.1414	0.8313	0.831
Echinococcus multilocularis	lamin	0.0027	0.0102	0.0084
Loa Loa (eye worm)	hypothetical protein	0.0288	0.1647	0.1645
Echinococcus granulosus	sodium and chloride dependent glycine	0.0288	0.1647	0.1632
Echinococcus granulosus	serotonin transporter	0.1699	1	1
Giardia lamblia	Sgs1 DNA helicase, putative	0.0021	0.0063	0.5
Loa Loa (eye worm)	intermediate filament tail domain-containing protein	0.0027	0.0102	0.0099
Loa Loa (eye worm)	hypothetical protein	0.0288	0.1647	0.1645
Schistosoma mansoni	intermediate filament proteins	0.0027	0.0102	0.0099
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0047	0.0218	0.0216
Trichomonas vaginalis	DNA helicase recq, putative	0.0021	0.0063	0.5
Toxoplasma gondii	ATP-dependent DNA helicase, RecQ family protein	0.0021	0.0063	0.0382
Loa Loa (eye worm)	hypothetical protein	0.0288	0.1647	0.1645
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0047	0.0218	0.0216
Plasmodium vivax	amine transporter, putative	0.0288	0.1647	1
Onchocerca volvulus		0.0288	0.1647	0.1561
Loa Loa (eye worm)	hypothetical protein	0.1699	1	1
Echinococcus granulosus	bloom syndrome protein	0.0021	0.0063	0.0045
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0047	0.0218	0.0216
Trypanosoma brucei	ATP-dependent DEAD/H DNA helicase recQ, putative	0.0021	0.0063	0.5
Echinococcus granulosus	ATP dependent DNA helicase Q5	0.0021	0.0063	0.0045
Leishmania major	ATP-dependent DEAD/H DNA helicase recQ, putative	0.0021	0.0063	0.5
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0002	0.000000000050872
Echinococcus multilocularis	musashi	0.0027	0.0102	0.0084
Echinococcus multilocularis	bloom syndrome protein	0.0021	0.0063	0.0045
Echinococcus granulosus	sodium:chloride dependent neurotransmitter	0.0288	0.1647	0.1632
Echinococcus multilocularis	sodium dependent neurotransmitter transporter	0.0288	0.1647	0.1632
Schistosoma mansoni	norepinephrine/norepinephrine transporter	0.1699	1	1
Onchocerca volvulus		0.0288	0.1647	0.1561
Schistosoma mansoni	norepinephrine/norepinephrine transporter	0.0288	0.1647	0.1645
Loa Loa (eye worm)	Sodium:neurotransmitter symporter family protein	0.0288	0.1647	0.1645
Loa Loa (eye worm)	ATP-dependent DNA helicase	0.0021	0.0063	0.006
Plasmodium vivax	ADP-dependent DNA helicase RecQ, putative	0.0011	0.0002	0.0015
Echinococcus granulosus	microtubule associated protein 2	0.1414	0.8313	0.831
Echinococcus multilocularis	sodium and chloride dependent glycine	0.0288	0.1647	0.1632
Echinococcus granulosus	ATP dependent DNA helicase Q1	0.0021	0.0063	0.0045
Brugia malayi	intermediate filament protein	0.0027	0.0102	0.0076
Brugia malayi	hypothetical protein	0.0288	0.1647	0.1625
Brugia malayi	ATP-dependent DNA helicase, RecQ family protein	0.0021	0.0063	0.0037
Treponema pallidum	sodium- and chloride- dependent transporter	0.1699	1	1
Onchocerca volvulus		0.1699	1	1
Plasmodium falciparum	amino acid transporter, putative	0.0288	0.1647	1
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0102	0.0099
Echinococcus granulosus	uncharacterized sodium dependent transporter	0.0288	0.1647	0.1632
Toxoplasma gondii	Sodium:neurotransmitter symporter family protein	0.0288	0.1647	1
Loa Loa (eye worm)	hypothetical protein	0.0288	0.1647	0.1645
Toxoplasma gondii	Sodium:neurotransmitter symporter family protein	0.0288	0.1647	1
Plasmodium vivax	hypothetical protein, conserved	0.0288	0.1647	1
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0099	0.0096
Loa Loa (eye worm)	Sodium:neurotransmitter symporter family protein	0.0288	0.1647	0.1645
Schistosoma mansoni	DNA helicase recq5	0.0021	0.0063	0.006
Trichomonas vaginalis	DNA helicase recq, putative	0.0021	0.0063	0.5
Echinococcus multilocularis	ATP dependent DNA helicase Q1	0.0021	0.0063	0.0045
Brugia malayi	Sodium:neurotransmitter symporter family protein 1, putative	0.0288	0.1647	0.1625
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0047	0.0218	0.0201
Loa Loa (eye worm)	cytoplasmic intermediate filament protein	0.0015	0.0026	0.0024
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0047	0.0218	0.0201
Loa Loa (eye worm)	hypothetical protein	0.1699	1	1
Echinococcus multilocularis	lamin dm0	0.0027	0.0102	0.0084
Echinococcus granulosus	intermediate filament protein	0.0027	0.0102	0.0084
Schistosoma mansoni	lamin	0.0027	0.0102	0.0099
Loa Loa (eye worm)	intermediate filament protein	0.0027	0.0102	0.0099
Schistosoma mansoni	norepinephrine/norepinephrine transporter	0.0288	0.1647	0.1645
Echinococcus multilocularis	serotonin transporter	0.1699	1	1
Echinococcus granulosus	uncharacterized sodium dependent transporter	0.0288	0.1647	0.1632
Plasmodium falciparum	transporter, putative	0.0288	0.1647	1
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0047	0.0218	0.0201
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0047	0.0218	0.0201
Echinococcus granulosus	sodium dependent neurotransmitter transporter	0.0288	0.1647	0.1632
Loa Loa (eye worm)	hypothetical protein	0.0013	0.0018	0.0015
Echinococcus multilocularis	uncharacterized sodium dependent transporter	0.0288	0.1647	0.1632
Brugia malayi	ATP-dependent DNA helicase, RecQ family protein	0.0021	0.0063	0.0037
Schistosoma mansoni	lamin	0.0027	0.0102	0.0099
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0047	0.0218	0.0192
Echinococcus multilocularis	ATP dependent DNA helicase Q5	0.0021	0.0063	0.0045
Schistosoma mansoni	sodium/chloride dependent transporter	0.0288	0.1647	0.1645
Loa Loa (eye worm)	hypothetical protein	0.1699	1	1
Brugia malayi	Sodium:neurotransmitter symporter family protein	0.0288	0.1647	0.1625
Toxoplasma gondii	ATP-dependent DNA helicase, RecQ family protein	0.0021	0.0063	0.0382
Chlamydia trachomatis	Ssodium-dependent amino acid transporter	0.0288	0.1647	0.5
Toxoplasma gondii	ATP-dependent DNA helicase, RecQ family protein	0.0011	0.0002	0.0015
Schistosoma mansoni	sodium-dependent neurotransmitter transporter	0.0288	0.1647	0.1645
Toxoplasma gondii	hypothetical protein	0.0288	0.1647	1
Schistosoma mansoni	sodium/chloride dependent neurotransmitter transporter	0.0288	0.1647	0.1645
Trichomonas vaginalis	DNA helicase recq1, putative	0.0021	0.0063	0.5
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0063	0.006
Entamoeba histolytica	recQ family helicase, putative	0.0021	0.0063	1
Loa Loa (eye worm)	serotonin transporter b	0.1699	1	1
Schistosoma mansoni	DNA helicase recq1	0.0021	0.0063	0.006
Schistosoma mansoni	sodium/chloride dependent transporter	0.0288	0.1647	0.1645
Trypanosoma cruzi	ATP-dependent DEAD/H DNA helicase recQ, putative	0.0021	0.0063	1
Schistosoma mansoni	microtubule-associated protein tau	0.1414	0.8313	0.8312
Schistosoma mansoni	sodium-dependent neurotransmitter transporter	0.0288	0.1647	0.1645
Loa Loa (eye worm)	hypothetical protein	0.0013	0.0015	0.0012
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0047	0.0218	0.0216
Loa Loa (eye worm)	norepinephrine transporter	0.1699	1	1
Brugia malayi	Sodium:neurotransmitter symporter family protein	0.0288	0.1647	0.1625
Echinococcus granulosus	sodium and chloride dependent glycine	0.0288	0.1647	0.1632
Loa Loa (eye worm)	hypothetical protein	0.0013	0.0015	0.0012
Brugia malayi	Bloom's syndrome protein homolog	0.0021	0.0063	0.0037
Echinococcus granulosus	lamin	0.0027	0.0102	0.0084
Schistosoma mansoni	sodium-dependent amino acid transporter	0.0288	0.1647	0.1645
Loa Loa (eye worm)	solute carrier family 6 member 4	0.1699	1	1
Echinococcus multilocularis	sodium and chloride dependent glycine	0.0288	0.1647	0.1632
Echinococcus granulosus	lamin dm0	0.0027	0.0102	0.0084
Loa Loa (eye worm)	RecQ helicase	0.0021	0.0063	0.006
Entamoeba histolytica	recQ family DNA helicase	0.0011	0.0002	0.0381
Schistosoma mansoni	sodium/chloride dependent neurotransmitter transporter	0.0288	0.1647	0.1645
Brugia malayi	Sodium:neurotransmitter symporter family protein	0.0288	0.1647	0.1625
Schistosoma mansoni	sodium/chloride dependent neurotransmitter transporter	0.0288	0.1647	0.1645

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

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Bibliographic References

No literature references available for this target.

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Detailed information for compound 797814