Detailed information for compound 799055

Basic information

Technical information
  • TDR Targets ID: 799055
  • Name: N-butan-2-yl-2-[[6-[(4-chlorophenyl)methyl]-5 ,7-dimethyl-[1,2,4]triazolo[1,5-a]pyrimidin-2 -yl]sulfanyl]acetamide
  • MW: 417.955 | Formula: C20H24ClN5OS
  • H donors: 1 H acceptors: 4 LogP: 4.96 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCC(NC(=O)CSc1nn2c(n1)nc(c(c2C)Cc1ccc(cc1)Cl)C)C
  • InChi: 1S/C20H24ClN5OS/c1-5-12(2)22-18(27)11-28-20-24-19-23-13(3)17(14(4)26(19)25-20)10-15-6-8-16(21)9-7-15/h6-9,12H,5,10-11H2,1-4H3,(H,22,27)
  • InChiKey: HBLDWOLVWVHVMY-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 2-[[6-[(4-chlorophenyl)methyl]-5,7-dimethyl-[1,2,4]triazolo[1,5-a]pyrimidin-2-yl]sulfanyl]-N-sec-butyl-acetamide
  • 2-[[6-[(4-chlorophenyl)methyl]-5,7-dimethyl-[1,2,4]triazolo[1,5-a]pyrimidin-2-yl]thio]-N-sec-butylacetamide
  • 2-[[6-(4-chlorobenzyl)-5,7-dimethyl-[1,2,4]triazolo[1,5-a]pyrimidin-2-yl]thio]-N-sec-butyl-acetamide
  • N-butan-2-yl-2-[[6-[(4-chlorophenyl)methyl]-5,7-dimethyl-[1,2,4]triazolo[1,5-a]pyrimidin-2-yl]sulfanyl]ethanamide

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi ImpB/MucB/SamB family protein 0.0021 0.01 0.01
Schistosoma mansoni FFA transport protein 0.0434 0.9225 1
Leishmania major acetyl-CoA synthetase, putative 0.0041 0.0546 0.0495
Leishmania major 4-coumarate:coa ligase-like protein 0.0041 0.0546 0.0495
Brugia malayi AMP-binding enzyme family protein 0.0041 0.0546 0.0546
Mycobacterium tuberculosis Probable esterase LipL 0.0035 0.0421 0.0446
Mycobacterium tuberculosis Probable polyketide synthase Pks8 0.004 0.0528 0.0563
Mycobacterium tuberculosis Probable polyketide synthase Pks5 0.0047 0.0691 0.0743
Brugia malayi AMP-binding enzyme family protein 0.0041 0.0546 0.0546
Mycobacterium ulcerans polyketide synthase 0.0049 0.0724 0.063
Mycobacterium ulcerans Type I modular polyketide synthase 0.0049 0.0724 0.063
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0049 0.0724 0.0683
Schistosoma mansoni hypothetical protein 0.0031 0.0329 0.0251
Loa Loa (eye worm) fatty acid synthase 0.0048 0.071 0.0616
Brugia malayi hypothetical protein 0.0025 0.0195 0.0195
Mycobacterium tuberculosis Probable polyketide synthase Pks1 0.0035 0.042 0.0445
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSD 0.0049 0.0724 0.0418
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0098 0.1806 0.1806
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0041 0.0546 0.0583
Echinococcus granulosus GPCR family 2 0.0031 0.0329 0.0251
Onchocerca volvulus Fatty acid synthase homolog 0.0088 0.159 0.5838
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0049 0.0724 0.0683
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtF 0.0046 0.0655 0.056
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsB 0.0039 0.0514 0.0417
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0469 1 1
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsC 0.0049 0.0724 0.0779
Mycobacterium tuberculosis Probable medium chain fatty-acid-CoA ligase FadD14 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0041 0.0546 0.0583
Loa Loa (eye worm) hypothetical protein 0.0088 0.1583 0.1498
Brugia malayi Latrophilin receptor protein 2 0.0031 0.0329 0.0329
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSC 0.0052 0.0791 0.0495
Brugia malayi oxidoreductase, zinc-binding dehydrogenase family protein 0.0093 0.169 0.169
Schistosoma mansoni hypothetical protein 0.0031 0.0329 0.0251
Mycobacterium ulcerans polyketide synthase 0.0052 0.0791 0.0698
Mycobacterium tuberculosis Polyketide synthase Pks2 0.0047 0.0691 0.0743
Leishmania major hypothetical protein, conserved 0.0025 0.0195 0.0105
Mycobacterium tuberculosis Probable polyketide synthase Pks9 0.0028 0.0259 0.0267
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0041 0.0546 0.0214
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative 0.0041 0.0546 0.8034
Entamoeba histolytica acyl-CoA synthetase, putative 0.0041 0.0546 0.8034
Mycobacterium tuberculosis Polyketide synthase Pks13 0.0073 0.1258 0.1367
Echinococcus multilocularis beta LACTamase domain containing family member 0.0035 0.0421 0.0352
Mycobacterium leprae Probable polyketide synthase Pks1 0.0052 0.0791 0.0495
Mycobacterium tuberculosis Peptide synthetase MbtE (peptide synthase) 0.0046 0.0655 0.0703
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0421 0.721
Mycobacterium leprae conserved hypothetical protein 0.0035 0.0421 0.0072
Mycobacterium ulcerans acyl-CoA synthetase 0.0041 0.0546 0.045
Toxoplasma gondii propionate-CoA ligase 0.0041 0.0546 0.4864
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsA 0.0039 0.0514 0.0417
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0046 0.0655 0.0655
Toxoplasma gondii AMP-binding enzyme domain-containing protein 0.003 0.0316 0.168
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) 0.0046 0.0655 0.0703
Brugia malayi AMP-binding enzyme family protein 0.0021 0.0102 0.0102
Brugia malayi ImpB/MucB/SamB family protein 0.0021 0.01 0.01
Echinococcus granulosus beta LACTamase domain containing family member 0.0035 0.0421 0.0352
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0195 0.0103
Trypanosoma brucei acetyl-CoA synthetase, putative 0.0041 0.0546 1
Toxoplasma gondii AMP-binding enzyme domain-containing protein 0.0041 0.0546 0.4864
Mycobacterium ulcerans thioesterase 0.0041 0.0545 0.0449
Brugia malayi latrophilin 2 splice variant baaae 0.0067 0.1122 0.1122
Mycobacterium ulcerans polyketide synthase Pks9 0.0032 0.0359 0.0261
Mycobacterium tuberculosis Conserved protein 0.0035 0.0421 0.0446
Mycobacterium ulcerans Type I modular polyketide synthase 0.0049 0.0724 0.063
Trypanosoma cruzi fatty acid transporter protein-like, putative 0.0434 0.9225 1
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD6 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0428 0.91 1
Mycobacterium ulcerans long-chain-acyl-CoA synthetase 0.0469 1 1
Brugia malayi AMP-binding enzyme family protein 0.0041 0.0546 0.0546
Leishmania major 4-coumarate:coa ligase-like protein 0.0041 0.0546 0.0495
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsE 0.0032 0.0359 0.0261
Loa Loa (eye worm) hypothetical protein 0.0041 0.0546 0.045
Mycobacterium leprae possible long-chain acyl-CoA synthase 0.0428 0.91 1
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0041 0.0546 0.0214
Mycobacterium ulcerans acyl-CoA synthetase 0.0041 0.0546 0.045
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0031 0.0329 0.0251
Mycobacterium tuberculosis PROBABLE FATTY-ACID-CoA LIGASE FADD18 (FRAGMENT) (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0035 0.0421 0.0445
Onchocerca volvulus 0.0126 0.2423 1
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0041 0.0546 0.045
Echinococcus multilocularis long chain fatty acid transport protein 4 0.0434 0.9225 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0049 0.0724 0.0683
Mycobacterium ulcerans multifunctional mycocerosic acid synthase membrane-associated Mas 0.0052 0.0791 0.0698
Mycobacterium ulcerans hypothetical protein 0.0041 0.0546 0.045
Loa Loa (eye worm) hypothetical protein 0.0025 0.0195 0.0095
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsD 0.0049 0.0724 0.063
Loa Loa (eye worm) hypothetical protein 0.0035 0.0421 0.0324
Mycobacterium tuberculosis Probable membrane bound polyketide synthase Pks6 0.0073 0.1258 0.1367
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0035 0.0421 0.0446
Trichomonas vaginalis antibiotic synthetase, putative 0.0041 0.0546 1
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsD 0.0049 0.0724 0.0779
Leishmania major hypothetical protein, conserved 0.0035 0.0421 0.0357
Mycobacterium leprae Probable multifunctional mycocerosic acid synthase membrane associated enzyme Mas 0.0052 0.0791 0.0495
Trypanosoma cruzi fatty acid transporter protein-like, putative 0.0434 0.9225 1
Mycobacterium ulcerans acyl-CoA synthetase 0.0041 0.0546 0.045
Brugia malayi AMP-binding enzyme family protein 0.0086 0.1554 0.1554
Toxoplasma gondii type I fatty acid synthase, putative 0.0058 0.0916 1
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSB 0.0039 0.0514 0.0177
Echinococcus granulosus acetyl coenzyme A synthetase cytoplasmic 0.0041 0.0546 0.0488
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0098 0.1806 0.1723
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0049 0.0724 0.0683
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtE 0.0046 0.0655 0.056
Trypanosoma brucei long-chain-fatty-acid-CoA ligase, putative 0.0041 0.0546 1
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0021 0.01 0.0092
Mycobacterium leprae Polyketide synthase Pks13 0.0073 0.1258 0.1028
Leishmania major fatty acid transporter protein-like protein 0.0428 0.91 1
Brugia malayi AMP-binding enzyme family protein 0.0041 0.0546 0.0546
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.0421 0.0352
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0421 0.0352
Loa Loa (eye worm) hypothetical protein 0.0098 0.1806 0.1723
Mycobacterium tuberculosis Probable polyketide synthase Pks15 0.002 0.0082 0.0072
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0086 0.1554 0.1692
Loa Loa (eye worm) hypothetical protein 0.0035 0.0421 0.0324
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSA 0.0049 0.0724 0.0418
Schistosoma mansoni hypothetical protein 0.0031 0.0329 0.0251
Trypanosoma brucei hypothetical protein, conserved 0.0035 0.0421 0.721
Mycobacterium tuberculosis Probable lipase LipD 0.0035 0.0421 0.0446
Mycobacterium leprae Probable lipase LipE 0.0035 0.0421 0.0072
Plasmodium vivax hypothetical protein, conserved 0.0035 0.0421 0.6461
Loa Loa (eye worm) acyl carrier protein 0.0022 0.0142 0.0042
Onchocerca volvulus 0.0041 0.0546 0.0621
Brugia malayi beta-lactamase family protein 0.0035 0.0421 0.0421
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0031 0.0329 0.0251
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0035 0.0421 0.0324
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0031 0.0329 0.0251
Leishmania major acetyl-CoA synthetase, putative 0.0041 0.0546 0.0495
Mycobacterium tuberculosis Conserved protein 0.0035 0.0421 0.0446
Plasmodium falciparum acetyl-CoA synthetase, putative 0.0041 0.0546 1
Entamoeba histolytica acyl-coA synthetase, putative 0.0041 0.0546 0.8034
Echinococcus multilocularis acetyl coenzyme A synthetase, cytoplasmic 0.0041 0.0546 0.0488
Mycobacterium leprae POSSIBLE FATTY-ACID-CoA LIGASE FADD10 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0041 0.0546 0.0214
Schistosoma mansoni hypothetical protein 0.0165 0.3298 0.3504
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0035 0.0421 0.0324
Loa Loa (eye worm) hypothetical protein 0.0035 0.0421 0.0324
Trypanosoma brucei PAB1-binding protein , putative 0.0025 0.0195 0.2116
Onchocerca volvulus 0.0041 0.0546 0.0621
Mycobacterium tuberculosis Polyketide synthase Pks12 0.0052 0.0791 0.0853
Mycobacterium tuberculosis Probable lipase LipE 0.0035 0.0421 0.0446
Loa Loa (eye worm) beta-lactamase 0.0035 0.0421 0.0324
Trichomonas vaginalis penicillin-binding protein, putative 0.0035 0.0421 0.721
Mycobacterium ulcerans acetyl-CoA synthetase 0.0041 0.0546 0.045
Plasmodium vivax acetyl-CoA synthetase, putative 0.0041 0.0546 1
Toxoplasma gondii Acetyl-coenzyme A synthetase 2, putative 0.0041 0.0546 0.4864
Mycobacterium leprae PROBABLE THIOESTERASE TESA 0.0041 0.0545 0.0212
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0225 0.4603 0.505
Loa Loa (eye worm) hypothetical protein 0.0041 0.0546 0.045
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase 0.0041 0.0546 0.0583
Mycobacterium tuberculosis Probable multifunctional mycocerosic acid synthase membrane-associated Mas 0.0052 0.0791 0.0853
Loa Loa (eye worm) hypothetical protein 0.0041 0.0546 0.045
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0041 0.0546 0.0583
Leishmania major long-chain-fatty-acid-CoA ligase, putative 0.0041 0.0546 0.0495
Mycobacterium ulcerans acyl-CoA synthetase 0.0046 0.0655 0.056
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0041 0.0546 0.0583
Mycobacterium ulcerans lipase LipD 0.0035 0.0421 0.0324
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0086 0.1554 0.1468
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0049 0.0724 0.0683
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0031 0.0329 0.0329
Trichomonas vaginalis antibiotic synthetase, putative 0.0041 0.0546 1
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.0421 0.0352
Loa Loa (eye worm) hypothetical protein 0.0035 0.0421 0.0324
Mycobacterium ulcerans acyl-CoA synthetase 0.0041 0.0546 0.045
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD10 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0041 0.0546 0.0583
Mycobacterium tuberculosis Conserved hypothetical protein 0.0021 0.01 0.0092
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0035 0.0421 0.0421
Entamoeba histolytica acyl-CoA synthetase, putative 0.0046 0.0655 1
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsA 0.0049 0.0724 0.0779
Toxoplasma gondii type I fatty acid synthase, putative 0.0035 0.0413 0.3032
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0035 0.0421 0.0446
Toxoplasma gondii ABC1 family protein 0.0035 0.0421 0.3143
Brugia malayi AMP-binding enzyme family protein 0.0041 0.0546 0.0546
Toxoplasma gondii beta-ketoacyl synthase, N-terminal domain-containing protein 0.0032 0.0345 0.2088
Loa Loa (eye worm) hypothetical protein 0.0067 0.1122 0.1032
Mycobacterium ulcerans acyl-CoA synthetase 0.0041 0.0546 0.045
Mycobacterium tuberculosis Probable thioesterase TesA 0.0041 0.0545 0.0581
Mycobacterium ulcerans thioesterase TesA 0.0041 0.0545 0.0449
Echinococcus granulosus geminin 0.0165 0.3298 0.3504
Loa Loa (eye worm) hypothetical protein 0.0041 0.0546 0.045
Onchocerca volvulus 0.0086 0.1554 0.5655
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0041 0.0546 0.045
Mycobacterium ulcerans acyl-CoA synthetase 0.0041 0.0546 0.045
Echinococcus multilocularis geminin 0.0165 0.3298 0.3504
Mycobacterium ulcerans beta-lactamase 0.0035 0.0421 0.0324
Loa Loa (eye worm) hypothetical protein 0.0041 0.0546 0.045
Loa Loa (eye worm) hypothetical protein 0.0035 0.0421 0.0324
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0049 0.0724 0.0683
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD1 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0041 0.0546 0.0583
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0049 0.0724 0.0683
Mycobacterium tuberculosis Peptide synthetase MbtF (peptide synthase) 0.0046 0.0655 0.0703
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0035 0.0421 0.0446
Loa Loa (eye worm) oxidoreductase 0.0041 0.0546 0.045
Mycobacterium ulcerans Type I modular polyketide synthase 0.0049 0.0724 0.063
Schistosoma mansoni hypothetical protein 0.0165 0.3298 0.3504
Leishmania major 4-coumarate:coa ligase-like protein 0.0041 0.0546 0.0495
Mycobacterium ulcerans polyketide synthase Pks13 0.0073 0.1258 0.1169
Mycobacterium ulcerans hypothetical protein 0.0035 0.0421 0.0324
Mycobacterium ulcerans esterase/lipase LipP 0.0035 0.0421 0.0324
Trichomonas vaginalis esterase, putative 0.0035 0.0421 0.721
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0041 0.0546 0.045
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0041 0.0546 0.045
Mycobacterium tuberculosis Probable polyketide synthase Pks7 0.0052 0.0791 0.0853
Mycobacterium tuberculosis Probable hydrolase 0.0035 0.0421 0.0446
Mycobacterium tuberculosis Conserved protein 0.0035 0.0421 0.0446
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0041 0.0546 0.0488
Mycobacterium leprae POSSIBLE O-SUCCINYLBENZOIC ACID--CoA LIGASE MENE (OSB-CoA SYNTHETASE) (O-SUCCINYLBENZOATE-CoA SYNTHASE) 0.0041 0.0546 0.0214
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD22 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) 0.0046 0.0655 0.0338
Onchocerca volvulus 0.0046 0.0655 0.1165
Brugia malayi beta-lactamase family protein 0.0035 0.0421 0.0421
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0041 0.0546 0.045
Schistosoma mansoni acetyl-CoA synthetase 0.0041 0.0546 0.0488
Loa Loa (eye worm) hypothetical protein 0.0031 0.0329 0.0231
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsC 0.0052 0.0791 0.0698
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 0.0046 0.0655 0.0703
Loa Loa (eye worm) hypothetical protein 0.0035 0.0421 0.0324
Mycobacterium tuberculosis Fatty-acid-CoA synthetase FadD17 (fatty-acid-CoA synthase) (fatty-acid-CoA ligase) 0.0041 0.0546 0.0583
Mycobacterium ulcerans O-succinylbenzoic acid--CoA ligase 0.0041 0.0546 0.045
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0421 0.0352
Brugia malayi acetyl-Coenzyme A synthetase 2 0.0041 0.0546 0.0546
Mycobacterium ulcerans acyl-CoA synthetase 0.0041 0.0546 0.045
Mycobacterium ulcerans phenyloxazoline synthase MbtB 0.0046 0.0655 0.056
Mycobacterium ulcerans acyl-CoA synthetase 0.0041 0.0546 0.045
Loa Loa (eye worm) latrophilin receptor protein 2 0.0031 0.0329 0.0231
Echinococcus granulosus long chain fatty acid transport protein 4 0.0434 0.9225 1
Brugia malayi Calcitonin receptor-like protein seb-1 0.0098 0.1806 0.1806
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0421 0.721
Mycobacterium ulcerans bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ACP synthetase 0.0041 0.0546 0.045
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0195 0.0103
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0421 0.721
Brugia malayi Beta-ketoacyl synthase, N-terminal domain containing protein 0.0049 0.0724 0.0724
Echinococcus multilocularis GPCR, family 2 0.0031 0.0329 0.0251
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0041 0.0546 0.0488
Loa Loa (eye worm) hypothetical protein 0.0027 0.025 0.0151
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0041 0.0546 0.0488
Mycobacterium ulcerans acyl-CoA synthetase 0.0041 0.0546 0.045
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0041 0.0546 0.0488
Schistosoma mansoni hypothetical protein 0.0067 0.1122 0.112
Mycobacterium ulcerans acyl-CoA synthetase 0.0041 0.0546 0.045
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0031 0.0329 0.0251
Schistosoma mansoni hypothetical protein 0.0031 0.0329 0.0251
Giardia lamblia DINP protein human, muc B family 0.0021 0.01 0.5
Trichomonas vaginalis penicillin-binding protein, putative 0.0035 0.0421 0.721
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0049 0.0724 0.063
Mycobacterium ulcerans peptide synthetase Nrp (peptide synthase) 0.0046 0.0655 0.056
Brugia malayi beta-lactamase 0.0035 0.0421 0.0421
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0049 0.0724 0.0724

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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