TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 437.488 | Formula: C24H27N3O5
H donors: 1 H acceptors: 3 LogP: 3.99 Rotable bonds: 8
Rule of 5 violations (Lipinski): 1
SMILES: CCOC(=O)N1CCC(CC1)N1C(Nc2ccccc2C(=O)OC)c2c(C1=O)cccc2
InChi: 1S/C24H27N3O5/c1-3-32-24(30)26-14-12-16(13-15-26)27-21(17-8-4-5-9-18(17)22(27)28)25-20-11-7-6-10-19(20)23(29)31-2/h4-11,16,21,25H,3,12-15H2,1-2H3
InChiKey: FRGGZSOGYGGEGZ-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Giardia lamblia	Sirtuin type 2	0.0147	0.1873	0.1873
Brugia malayi	beta-lactamase	0.0036	0.0273	0.0273
Leishmania major	calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative	0.0041	0.0345	0.0345
Brugia malayi	Peptidase family M1 containing protein	0.0035	0.0269	0.0269
Loa Loa (eye worm)	hypothetical protein	0.0079	0.0899	0.0816
Toxoplasma gondii	histone deacetylase SIR2-like	0.0147	0.1873	0.5632
Loa Loa (eye worm)	thioredoxin reductase	0.0048	0.0446	0.0358
Trichomonas vaginalis	chromatin regulatory protein sir2, putative	0.0471	0.6519	0.6519
Brugia malayi	transcriptional regulator, Sir2 family protein	0.0147	0.1873	0.1873
Trypanosoma brucei	trypanothione reductase	0.0048	0.0446	0.0446
Mycobacterium tuberculosis	Conserved protein	0.0036	0.0273	0.082
Trichomonas vaginalis	chromatin regulatory protein sir2, putative	0.0471	0.6519	0.6519
Plasmodium vivax	thioredoxin reductase, putative	0.0048	0.0446	0.1341
Schistosoma mansoni	calpain C (C02 family)	0.0041	0.0345	0.0345
Loa Loa (eye worm)	glutathione reductase	0.0048	0.0446	0.0358
Trichomonas vaginalis	chromatin regulatory protein sir2, putative	0.0147	0.1873	0.1873
Trypanosoma cruzi	calpain-like cysteine peptidase, putative	0.0041	0.0345	0.0345
Loa Loa (eye worm)	beta-lactamase	0.0036	0.0273	0.0183
Plasmodium falciparum	transcriptional regulatory protein sir2b	0.0147	0.1873	0.5632
Entamoeba histolytica	aminopeptidase, putative	0.0035	0.0269	0.01
Trypanosoma brucei	prefoldin subunit, putative	0.0031	0.0207	0.0207
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0273	0.0183
Mycobacterium tuberculosis	Probable polypeptide deformylase Def (PDF) (formylmethionine deformylase)	0.0248	0.3326	1
Leishmania major	kinesin, putative	0.0028	0.0171	0.0171
Trypanosoma brucei	calpain-like protein, putative	0.0041	0.0345	0.0345
Leishmania major	calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative	0.0041	0.0345	0.0345
Brugia malayi	calpain 7	0.0041	0.0345	0.0345
Brugia malayi	Thioredoxin reductase	0.0048	0.0446	0.0446
Trypanosoma cruzi	kinesin, putative	0.0028	0.0171	0.0171
Trichomonas vaginalis	Clan MA, family M1, aminopeptidase N-like metallopeptidase	0.0035	0.0269	0.0269
Trypanosoma brucei	hypothetical protein, conserved	0.0036	0.0273	0.0273
Loa Loa (eye worm)	calpain family protein 1	0.0108	0.1306	0.1226
Toxoplasma gondii	ABC1 family protein	0.0036	0.0273	0.082
Onchocerca volvulus		0.0036	0.0273	0.0087
Trypanosoma brucei	calpain-like protein, putative	0.0041	0.0345	0.0345
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0046	0.0421	0.0421
Mycobacterium tuberculosis	Probable NADH dehydrogenase Ndh	0.0109	0.132	0.397
Trichomonas vaginalis	Clan MA, family M1, aminopeptidase N-like metallopeptidase	0.0035	0.0269	0.0269
Brugia malayi	Peptidase family M1 containing protein	0.0035	0.0269	0.0269
Brugia malayi	calpain 5	0.0028	0.0171	0.0171
Trypanosoma cruzi	metallo-peptidase, clan MA(E), family M1, putative	0.0035	0.0269	0.0269
Echinococcus multilocularis	thioredoxin glutathione reductase	0.0048	0.0446	0.0446
Trichomonas vaginalis	chromatin regulatory protein sir2, putative	0.0147	0.1873	0.1873
Mycobacterium tuberculosis	Probable lipase LipD	0.0036	0.0273	0.082
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0046	0.0421	0.0421
Brugia malayi	calpain family protein 1	0.0108	0.1306	0.1306
Trypanosoma cruzi	hypothetical protein, conserved	0.0036	0.0273	0.0273
Schistosoma mansoni	cytosol alanyl aminopeptidase (M01 family)	0.0035	0.0269	0.0269
Echinococcus granulosus	NAD dependent deacetylase sirtuin 7	0.0147	0.1873	0.1873
Trypanosoma cruzi	cysteine peptidase, Clan CA, family C2, putative	0.0041	0.0345	0.0345
Mycobacterium tuberculosis	NAD(P)H quinone reductase LpdA	0.0121	0.1494	0.4492
Chlamydia trachomatis	peptide deformylase	0.0248	0.3326	1
Plasmodium vivax	hypothetical protein, conserved	0.0147	0.1873	0.5632
Trichomonas vaginalis	chromatin regulatory protein sir2, putative	0.0147	0.1873	0.1873
Leishmania major	prefoldin subunit, putative	0.0031	0.0207	0.0207
Brugia malayi	glutathione reductase	0.0048	0.0446	0.0446
Schistosoma mansoni	family M1 non-peptidase homologue (M01 family)	0.0023	0.0091	0.0091
Trypanosoma cruzi	Silent information regulator 2 related protein 1	0.0714	1	1
Giardia lamblia	Hypothetical protein	0.0031	0.0207	0.0207
Brugia malayi	hypothetical protein	0.0035	0.0269	0.0269
Wolbachia endosymbiont of Brugia malayi	peptide deformylase	0.0248	0.3326	1
Toxoplasma gondii	hypothetical protein	0.0248	0.3326	1
Plasmodium falciparum	transcriptional regulatory protein sir2a	0.0147	0.1873	0.5632
Echinococcus granulosus	beta LACTamase domain containing family member	0.0036	0.0273	0.0273
Echinococcus granulosus	puromycin sensitive aminopeptidase	0.0035	0.0269	0.0269
Mycobacterium ulcerans	beta-lactamase	0.0036	0.0273	0.082
Schistosoma mansoni	Mername-AA248 (C02 family)	0.0041	0.0345	0.0345
Mycobacterium leprae	DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE	0.0121	0.1494	0.4
Mycobacterium tuberculosis	Probable reductase	0.0109	0.132	0.397
Echinococcus granulosus	calpain A	0.0112	0.1376	0.1376
Mycobacterium tuberculosis	NADPH-dependent mycothiol reductase Mtr	0.0048	0.0446	0.1341
Leishmania major	calpain, putative,cysteine peptidase, Clan CA, family C2, putative	0.0041	0.0345	0.0345
Mycobacterium tuberculosis	Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB	0.0109	0.132	0.397
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0046	0.0421	0.0421
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0273	0.0183
Echinococcus granulosus	thyrotropin releasing hormone receptor	0.0248	0.3319	0.3319
Mycobacterium leprae	PROBABLE POLYPEPTIDE DEFORMYLASE DEF (PDF) (FORMYLMETHIONINE DEFORMYLASE)	0.0248	0.3326	1
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0036	0.0273	0.0273
Mycobacterium tuberculosis	Transcriptional regulatory protein	0.0147	0.1873	0.5632
Schistosoma mansoni	family C2 unassigned peptidase (C02 family)	0.0108	0.1306	0.1306
Mycobacterium tuberculosis	Probable hydrolase	0.0036	0.0273	0.082
Mycobacterium tuberculosis	Probable conserved lipoprotein	0.0036	0.0273	0.082
Trypanosoma brucei	calpain-like cysteine peptidase, putative	0.0041	0.0345	0.0345
Echinococcus granulosus	calpain	0.0041	0.0345	0.0345
Trichomonas vaginalis	esterase, putative	0.0036	0.0273	0.0273
Echinococcus multilocularis	NAD dependent deacetylase sirtuin 6	0.0147	0.1873	0.1873
Trypanosoma cruzi	cysteine peptidase, Clan CA, family C2, putative	0.0041	0.0345	0.0345
Trypanosoma brucei	Aminopeptidase M1, putative	0.0035	0.0269	0.0269
Schistosoma mansoni	chromatin regulatory protein sir2	0.0147	0.1873	0.1873
Trypanosoma cruzi	polypeptide deformylase-like protein, putative	0.0095	0.1123	0.1123
Trichomonas vaginalis	chromatin regulatory protein sir2, putative	0.0714	1	1
Trypanosoma cruzi	cysteine peptidase, Clan CA, family C2, putative	0.0041	0.0345	0.0345
Schistosoma mansoni	chromatin regulatory protein sir2	0.0714	1	1
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0207	0.0117
Echinococcus multilocularis	calpain	0.0041	0.0345	0.0345
Echinococcus multilocularis	thyrotropin releasing hormone receptor	0.0248	0.3319	0.3319
Plasmodium falciparum	prefoldin subunit 6, putative	0.0031	0.0207	0.0624
Schistosoma mansoni	hypothetical protein	0.0031	0.0207	0.0207
Brugia malayi	calpain family protein 1	0.0108	0.1306	0.1306
Echinococcus granulosus	prefoldin subunit 6	0.0031	0.0207	0.0207
Mycobacterium tuberculosis	Possible penicillin-binding protein	0.0227	0.3017	0.9072
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0046	0.0421	0.0421
Trypanosoma brucei	calpain-like protein, putative	0.0041	0.0345	0.0345
Mycobacterium ulcerans	hypothetical protein	0.0036	0.0273	0.082
Trichomonas vaginalis	D-aminoacylase, putative	0.0036	0.0273	0.0273
Echinococcus granulosus	calpain A	0.0041	0.0345	0.0345
Trypanosoma brucei	Polypeptide deformylase 1	0.0095	0.1123	0.1123
Trypanosoma cruzi	Silent information regulator 2 related protein 1	0.0714	1	1
Trypanosoma cruzi	metallo-peptidase, Clan MA(E) Family M1	0.0023	0.0091	0.0091
Trypanosoma cruzi	kinesin, putative	0.0028	0.0171	0.0171
Onchocerca volvulus		0.0036	0.0273	0.0087
Leishmania major	trypanothione reductase	0.0048	0.0446	0.0446
Plasmodium falciparum	glutathione reductase	0.0048	0.0446	0.1341
Trypanosoma brucei	calpain-like protein, putative	0.0041	0.0345	0.0345
Trypanosoma brucei	antigen, putative	0.0041	0.0345	0.0345
Plasmodium falciparum	thioredoxin reductase	0.0048	0.0446	0.1341
Mycobacterium ulcerans	aminopeptidase N PepN	0.0035	0.0269	0.0808
Brugia malayi	Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative	0.0036	0.0273	0.0273
Trypanosoma cruzi	cysteine peptidase, Clan CA, family C2, putative	0.0041	0.0345	0.0345
Schistosoma mansoni	aminopeptidase PILS (M01 family)	0.0035	0.0269	0.0269
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0273	0.0183
Trypanosoma cruzi	Aminopeptidase M1, putative	0.0035	0.0269	0.0269
Plasmodium falciparum	peptide deformylase	0.0248	0.3326	1
Entamoeba histolytica	Sir2 family transcriptional regulator, putative	0.0714	1	1
Mycobacterium ulcerans	Sir2-like regulatory protein	0.0147	0.1873	0.5632
Trypanosoma cruzi	prefoldin subunit, putative	0.0031	0.0207	0.0207
Leishmania major	NAD dependent deacetylase, putative,transcriptional regulator, Sir2 family protein, nicotinic acid mononucleotide 5,6-dimethylbe	0.0147	0.1873	0.1873
Loa Loa (eye worm)	hypothetical protein	0.0108	0.1306	0.1226
Trypanosoma cruzi	calpain-like cysteine peptidase, putative	0.0041	0.0345	0.0345
Leishmania major	aminopeptidase, putative,metallo-peptidase, Clan MA(E), Family M1	0.0035	0.0269	0.0269
Trichomonas vaginalis	chromatin regulatory protein sir2, putative	0.0147	0.1873	0.1873
Trichomonas vaginalis	D-aminoacylase, putative	0.0036	0.0273	0.0273
Loa Loa (eye worm)	sirtuin 4	0.0147	0.1873	0.1798
Brugia malayi	KE2 family protein	0.0031	0.0207	0.0207
Echinococcus granulosus	calpain 7 C02 family	0.0041	0.0345	0.0345
Echinococcus multilocularis	Peptidase M1, membrane alanine aminopeptidase, N terminal	0.0035	0.0269	0.0269
Plasmodium vivax	calpain, putative	0.0041	0.0345	0.1039
Trypanosoma brucei	SIR2-like protein 4, putative	0.0147	0.1873	0.1873
Echinococcus multilocularis	puromycin sensitive aminopeptidase	0.0035	0.0269	0.0269
Echinococcus multilocularis	puromycin sensitive aminopeptidase	0.0035	0.0269	0.0269
Schistosoma mansoni	thyrotropin-releasing hormone receptor	0.0248	0.3319	0.3319
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0273	0.0183
Echinococcus granulosus	calpain 5	0.0041	0.0345	0.0345
Entamoeba histolytica	Sir2 family transcriptional regulator, putative	0.0147	0.1873	0.1732
Trypanosoma cruzi	calpain-like cysteine peptidase, putative	0.0041	0.0345	0.0345
Echinococcus granulosus	aminopeptidase N	0.0035	0.0269	0.0269
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0036	0.0273	0.0273
Trypanosoma brucei	metallo-peptidase, Clan MA(E) Family M1	0.0035	0.0269	0.0269
Brugia malayi	NAD-dependent deacetylase SIRT1	0.0471	0.6519	0.6519
Mycobacterium tuberculosis	Probable oxidoreductase	0.0121	0.1494	0.4492
Mycobacterium ulcerans	esterase/lipase LipP	0.0036	0.0273	0.082
Trypanosoma cruzi	Silent information regulator 2 related protein 3	0.0147	0.1873	0.1873
Treponema pallidum	polypeptide deformylase (def)	0.0248	0.3326	1
Loa Loa (eye worm)	calpain 5	0.0028	0.0171	0.008
Trichomonas vaginalis	chromatin regulatory protein sir2, putative	0.0471	0.6519	0.6519
Schistosoma mansoni	calpain-7 (C02 family)	0.0041	0.0345	0.0345
Plasmodium vivax	glutathione reductase, putative	0.0048	0.0446	0.1341
Onchocerca volvulus		0.0067	0.0724	1
Trypanosoma cruzi	trypanothione reductase, putative	0.0048	0.0446	0.0446
Trichomonas vaginalis	chromatin regulatory protein sir2, putative	0.0714	1	1
Plasmodium vivax	NAD-dependent deacetylase, putative	0.0147	0.1873	0.5632
Echinococcus multilocularis	puromycin sensitive aminopeptidase	0.0023	0.0091	0.0091
Trichomonas vaginalis	D-aminoacylase, putative	0.0036	0.0273	0.0273
Entamoeba histolytica	Sir2 family transcriptional regulator, putative	0.0714	1	1
Echinococcus granulosus	puromycin sensitive aminopeptidase	0.0035	0.0269	0.0269
Trypanosoma brucei	Silent information regulator 2 related protein 3	0.0147	0.1873	0.1873
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0046	0.0421	0.0333
Schistosoma mansoni	family C2 unassigned peptidase (C02 family)	0.0112	0.1376	0.1376
Echinococcus multilocularis	chromatin regulatory protein sir2	0.0714	1	1
Echinococcus multilocularis	calpain 7 (C02 family)	0.0041	0.0345	0.0345
Trichomonas vaginalis	penicillin-binding protein, putative	0.0036	0.0273	0.0273
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0273	0.0183
Loa Loa (eye worm)	calpain family protein 1	0.0079	0.0899	0.0816
Schistosoma mansoni	chromatin regulatory protein sir2	0.0714	1	1
Mycobacterium ulcerans	lipase LipD	0.0036	0.0273	0.082
Toxoplasma gondii	thioredoxin reductase	0.0048	0.0446	0.1341
Mycobacterium tuberculosis	Probable dehydrogenase	0.0109	0.132	0.397
Trypanosoma cruzi	Peptide deformylase 2, putative	0.0095	0.1123	0.1123
Loa Loa (eye worm)	hypothetical protein	0.0095	0.1131	0.105
Echinococcus multilocularis	calpain 5	0.0041	0.0345	0.0345
Trypanosoma cruzi	polypeptide deformylase-like protein, putative	0.0095	0.1123	0.1123
Trypanosoma cruzi	hypothetical protein, conserved	0.0036	0.0273	0.0273
Mycobacterium tuberculosis	Probable membrane NADH dehydrogenase NdhA	0.0109	0.132	0.397
Plasmodium vivax	hypothetical protein, conserved	0.0036	0.0273	0.082
Onchocerca volvulus		0.0036	0.0273	0.0087
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0046	0.0421	0.0421
Giardia lamblia	NAD-dependent histone deacetylase Sir2	0.0471	0.6519	0.6519
Trypanosoma cruzi	prefoldin subunit, putative	0.0031	0.0207	0.0207
Brugia malayi	beta-lactamase family protein	0.0036	0.0273	0.0273
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0046	0.0421	0.0421
Echinococcus multilocularis	puromycin sensitive aminopeptidase	0.0035	0.0269	0.0269
Giardia lamblia	Transcriptional regulator, Sir2 family	0.0147	0.1873	0.1873
Trichomonas vaginalis	penicillin-binding protein, putative	0.0036	0.0273	0.0273
Giardia lamblia	Hypothetical protein	0.0714	1	1
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0273	0.0183
Mycobacterium tuberculosis	Probable lipase LipE	0.0036	0.0273	0.082
Trypanosoma brucei	Peptide deformylase 2	0.0095	0.1123	0.1123
Mycobacterium leprae	PROBABLE NADH DEHYDROGENASE NDH	0.0109	0.132	0.3431
Loa Loa (eye worm)	transcriptional regulator	0.0147	0.1873	0.1798
Echinococcus multilocularis	NAD dependent deacetylase sirtuin 1	0.0471	0.6519	0.6519
Toxoplasma gondii	prefoldin subunit 6, putative	0.0031	0.0207	0.0624
Loa Loa (eye worm)	subtilase	0.027	0.3638	0.358
Trypanosoma cruzi	Silent information regulator 2 related protein 3	0.0147	0.1873	0.1873
Mycobacterium ulcerans	NAD-dependent deacetylase	0.0147	0.1873	0.5632
Echinococcus multilocularis	calpain A	0.0112	0.1376	0.1376
Echinococcus granulosus	family C2 unassigned peptidase C02 family	0.0112	0.1376	0.1376
Loa Loa (eye worm)	transcriptional regulator	0.0714	1	1
Schistosoma mansoni	calpain (C02 family)	0.0041	0.0345	0.0345
Echinococcus multilocularis	hypothetical protein	0.0041	0.0345	0.0345
Trypanosoma cruzi	Peptide deformylase 2, putative	0.0095	0.1123	0.1123
Echinococcus multilocularis	prefoldin subunit 6	0.0031	0.0207	0.0207
Loa Loa (eye worm)	aminopeptidase N	0.0035	0.0269	0.0179
Echinococcus granulosus	peptidase s8 s53 subtilisin kexin sedolisin	0.0101	0.1214	0.1214
Trypanosoma cruzi	calpain cysteine peptidase, putative	0.0041	0.0345	0.0345
Leishmania major	polypeptide deformylase-like protein, putative	0.0095	0.1123	0.1123
Mycobacterium tuberculosis	Probable esterase LipL	0.0036	0.0273	0.082
Echinococcus granulosus	thioredoxin glutathione reductase	0.0048	0.0446	0.0446
Schistosoma mansoni	chromatin regulatory protein sir2	0.0714	1	1
Echinococcus multilocularis	family C2 unassigned peptidase (C02 family)	0.0112	0.1376	0.1376
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0046	0.0421	0.0421
Schistosoma mansoni	chromatin regulatory protein sir2	0.0147	0.1873	0.1873
Trypanosoma brucei	Silent information regulator 2 related protein 1	0.0714	1	1
Trypanosoma brucei	Aminopeptidase M1, putative	0.0035	0.0269	0.0269
Echinococcus multilocularis	puromycin sensitive aminopeptidase	0.0035	0.0269	0.0269
Plasmodium vivax	peptide deformylase, putative	0.0248	0.3326	1
Mycobacterium ulcerans	peptide deformylase	0.0248	0.3326	1
Echinococcus multilocularis	beta LACTamase domain containing family member	0.0036	0.0273	0.0273
Trypanosoma brucei	cysteine peptidase, Clan CA, family C2, putative	0.0041	0.0345	0.0345
Leishmania major	silent information regulator 2, putative	0.0714	1	1
Leishmania major	aminopeptidase-like protein,metallo-peptidase, Clan MA(E), Family M1	0.0035	0.0269	0.0269
Brugia malayi	beta-lactamase family protein	0.0036	0.0273	0.0273
Schistosoma mansoni	tripeptidyl-peptidase II (S08 family)	0.027	0.3638	0.3638
Entamoeba histolytica	hypothetical protein, conserved	0.0147	0.1873	0.1732
Echinococcus granulosus	chromatin regulatory protein sir2	0.0714	1	1
Echinococcus multilocularis	NAD dependent deacetylase sirtuin 7	0.0147	0.1873	0.1873
Trichomonas vaginalis	chromatin regulatory protein sir2, putative	0.0471	0.6519	0.6519
Echinococcus granulosus	puromycin sensitive aminopeptidase	0.0035	0.0269	0.0269
Mycobacterium tuberculosis	Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras	0.0121	0.1494	0.4492
Trypanosoma cruzi	calpain-like cysteine peptidase, putative	0.0041	0.0345	0.0345
Echinococcus granulosus	NAD dependent deacetylase sirtuin 6	0.0147	0.1873	0.1873
Entamoeba histolytica	NAD-dependent deacetylase 1, putative	0.0147	0.1873	0.1732
Trypanosoma brucei	kinesin, putative	0.0028	0.0171	0.0171
Mycobacterium tuberculosis	Putative ferredoxin reductase	0.0109	0.132	0.397
Echinococcus granulosus	NAD dependent deacetylase sirtuin 1	0.0471	0.6519	0.6519
Loa Loa (eye worm)	transcriptional regulator	0.0147	0.1873	0.1798
Mycobacterium tuberculosis	Conserved protein	0.0036	0.0273	0.082
Echinococcus multilocularis	aminopeptidase N	0.0035	0.0269	0.0269
Trypanosoma cruzi	calpain-like cysteine peptidase, putative	0.0041	0.0345	0.0345
Loa Loa (eye worm)	hypothetical protein	0.0324	0.4409	0.4358
Echinococcus granulosus	NAD dependent deacetylase sirtuin 3	0.0714	1	1
Echinococcus granulosus	puromycin sensitive aminopeptidase	0.0035	0.0269	0.0269
Schistosoma mansoni	calpain-7 (C02 family)	0.0041	0.0345	0.0345
Leishmania major	hypothetical protein, conserved	0.0036	0.0273	0.0273
Echinococcus multilocularis	Peptidase S8 S53, subtilisin kexin sedolisin	0.0101	0.1214	0.1214
Schistosoma mansoni	chromatin regulatory protein sir2	0.0471	0.6519	0.6519
Toxoplasma gondii	histone deacetylase SIR2	0.0147	0.1873	0.5632
Loa Loa (eye worm)	beta-LACTamase domain containing family member	0.0036	0.0273	0.0183
Trichomonas vaginalis	chromatin regulatory protein sir2, putative	0.0147	0.1873	0.1873
Loa Loa (eye worm)	calpain	0.0041	0.0345	0.0257
Leishmania major	sir2-family protein-like protein	0.0147	0.1873	0.1873
Loa Loa (eye worm)	hypothetical protein	0.0067	0.0724	0.0639
Brugia malayi	transcriptional regulator, Sir2 family protein	0.0147	0.1873	0.1873
Mycobacterium tuberculosis	Probable esterase/lipase LipP	0.0036	0.0273	0.082
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0046	0.0421	0.0421
Mycobacterium tuberculosis	Possible conserved lipoprotein LpqK	0.0036	0.0273	0.082
Echinococcus multilocularis	puromycin sensitive aminopeptidase	0.0035	0.0269	0.0269
Trichomonas vaginalis	conserved hypothetical protein	0.0031	0.0207	0.0207
Mycobacterium ulcerans	fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE	0.0036	0.0273	0.082
Echinococcus multilocularis	NAD dependent deacetylase sirtuin 3	0.0714	1	1
Trypanosoma cruzi	aminopeptidase, putative	0.0035	0.0269	0.0269
Schistosoma mansoni	family C2 unassigned peptidase (C02 family)	0.0112	0.1376	0.1376
Mycobacterium tuberculosis	Conserved protein	0.0036	0.0273	0.082
Schistosoma mansoni	chromatin regulatory protein sir2	0.0147	0.1873	0.1873
Brugia malayi	Subtilase family protein	0.027	0.3638	0.3638
Echinococcus multilocularis	calpain family protein 1, d	0.0079	0.0899	0.0899
Loa Loa (eye worm)	hypothetical protein	0.0471	0.6519	0.6487
Entamoeba histolytica	prefoldin subunit 6, putative	0.0031	0.0207	0.0038
Plasmodium vivax	prefoldin subunit 6, putative	0.0031	0.0207	0.0624

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

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Bibliographic References

No literature references available for this target.

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Detailed information for compound 805145