TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 490.637 | Formula: C29H38N4O3
H donors: 0 H acceptors: 3 LogP: 3.4 Rotable bonds: 7
Rule of 5 violations (Lipinski): 1
SMILES: Cc1cccc(c1)CN1CCN(CC1)C(=O)c1cn(cc(c1=O)C(=O)N1CCCCC1)C1CCCC1
InChi: 1S/C29H38N4O3/c1-22-8-7-9-23(18-22)19-30-14-16-32(17-15-30)29(36)26-21-33(24-10-3-4-11-24)20-25(27(26)34)28(35)31-12-5-2-6-13-31/h7-9,18,20-21,24H,2-6,10-17,19H2,1H3
InChiKey: VMMUEMXCOCDYRG-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Leishmania major	cathepsin L-like protease	0.0058	0.0395	0.257
Toxoplasma gondii	aldehyde dehydrogenase	0.0059	0.0403	0.2549
Echinococcus granulosus	neutral alpha glucosidase AB	0.008	0.0657	0.0824
Echinococcus granulosus	expressed conserved protein	0.0098	0.0874	0.1101
Entamoeba histolytica	cysteine protease, putative	0.0058	0.0395	0.4159
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0015	0.002
Schistosoma mansoni	tar DNA-binding protein	0.0067	0.0504	0.0626
Loa Loa (eye worm)	hypothetical protein	0.0051	0.0309	0.0395
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0058	0.0395	0.3632
Toxoplasma gondii	glycosyl hydrolase, family 31 protein	0.008	0.0657	0.4221
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0308	0.3395	0.4336
Onchocerca volvulus		0.0051	0.0309	0.0482
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.0113	0.1061	1
Leishmania major	cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like	0.0113	0.1061	0.6902
Loa Loa (eye worm)	hypothetical protein	0.0051	0.0309	0.0395
Leishmania major	cathepsin L-like protease	0.0058	0.0395	0.257
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0058	0.0395	0.3632
Brugia malayi	cathepsin B-like cysteine proteinase	0.0308	0.3395	0.4347
Trichomonas vaginalis	alpha-glucosidase, putative	0.008	0.0657	0.6143
Entamoeba histolytica	cysteine protease, putative	0.0058	0.0395	0.4159
Loa Loa (eye worm)	hypothetical protein	0.0051	0.0309	0.0395
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0058	0.0395	0.3632
Loa Loa (eye worm)	hypothetical protein	0.0051	0.0309	0.0395
Onchocerca volvulus		0.0058	0.0395	0.0616
Echinococcus multilocularis	sterol regulatory element binding protein	0.0045	0.0236	0.0221
Trypanosoma cruzi	glycosyl hydrolase-like protein, putative	0.008	0.0657	0.19
Brugia malayi	Cathepsin L-like precursor	0.0058	0.0395	0.0506
Leishmania major	aldehyde dehydrogenase, mitochondrial precursor	0.0059	0.0403	0.2623
Onchocerca volvulus	Chorion peroxidase homolog	0.0051	0.0309	0.0482
Onchocerca volvulus	Cathepsin L homolog	0.0058	0.0395	0.0616
Echinococcus granulosus	sterol regulatory element binding protein	0.0045	0.0236	0.0283
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0058	0.0395	0.0487
Plasmodium falciparum	cysteine proteinase falcipain 1	0.0058	0.0395	1
Entamoeba histolytica	cysteine protease, putative	0.0058	0.0395	0.4159
Trichomonas vaginalis	alpha-glucosidase, putative	0.008	0.0657	0.6143
Echinococcus multilocularis	aldehyde dehydrogenase, mitochondrial	0.0059	0.0403	0.0388
Brugia malayi	cathepsin L precursor	0.0026	0.0015	0.002
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0058	0.0395	0.3632
Brugia malayi	Cathepsin L-like precursor	0.0058	0.0395	0.0506
Leishmania major	glycosyl hydrolase-like protein	0.008	0.0657	0.4279
Trypanosoma cruzi	fructose-1,6-bisphosphatase, cytosolic, putative	0.0153	0.1537	0.4501
Loa Loa (eye worm)	animal heme peroxidase	0.0051	0.0309	0.0395
Loa Loa (eye worm)	Papain cysteine protease/cathepsin propeptide inhibitor-containing protein	0.0058	0.0395	0.0506
Schistosoma mansoni	tar DNA-binding protein	0.0067	0.0504	0.0626
Echinococcus multilocularis	cathepsin b	0.0308	0.3395	0.3385
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0058	0.0395	0.3632
Echinococcus multilocularis	expressed conserved protein	0.0098	0.0874	0.086
Loa Loa (eye worm)	hypothetical protein	0.0051	0.0309	0.0395
Echinococcus multilocularis	lysosomal alpha glucosidase	0.0676	0.7811	0.7808
Loa Loa (eye worm)	hypothetical protein	0.0051	0.0309	0.0395
Brugia malayi	cathepsin Z-like cysteine proteinase	0.0026	0.0015	0.002
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0059	0.0403	1
Echinococcus multilocularis	neutral alpha glucosidase AB	0.008	0.0657	0.0643
Onchocerca volvulus	Uncharacterized family 31 glucosidase KIAA1161 homolog	0.008	0.0657	0.1026
Brugia malayi	cathepsin Z-like cysteine proteinase	0.0026	0.0015	0.002
Leishmania major	cysteine peptidase A (CPA)	0.0058	0.0395	0.257
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0015	0.002
Loa Loa (eye worm)	RNA binding protein	0.0067	0.0504	0.0645
Entamoeba histolytica	cysteine protease, putative	0.0026	0.0015	0.0161
Trypanosoma brucei	fructose-1,6-bisphosphatase	0.0153	0.1537	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0058	0.0395	0.3632
Trichomonas vaginalis	alpha-glucosidase, putative	0.008	0.0657	0.6143
Loa Loa (eye worm)	hypothetical protein	0.0058	0.0395	0.0506
Trypanosoma cruzi	hypothetical protein, conserved	0.008	0.0657	0.19
Trichomonas vaginalis	alpha-glucosidase, putative	0.008	0.0657	0.6143
Plasmodium vivax	vivapain-2	0.0058	0.0395	1
Trypanosoma cruzi	cruzipain precursor, putative	0.0058	0.0395	0.1123
Echinococcus multilocularis	cathepsin b	0.0308	0.3395	0.3385
Brugia malayi	Papain family cysteine protease containing protein	0.0058	0.0395	0.0506
Entamoeba histolytica	cysteine protease, putative	0.0058	0.0395	0.4159
Entamoeba histolytica	cysteine proteinase, putative	0.0058	0.0395	0.4159
Entamoeba histolytica	cysteine protease, putative	0.0058	0.0395	0.4159
Loa Loa (eye worm)	hypothetical protein	0.0051	0.0309	0.0395
Entamoeba histolytica	glycosyl hydrolase, family 31 protein	0.008	0.0657	0.6924
Schistosoma mansoni	hypothetical protein	0.0043	0.0216	0.0258
Echinococcus granulosus	cathepsin L	0.0058	0.0395	0.0487
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0308	0.3395	0.4336
Brugia malayi	Cathepsin L-like precursor	0.0058	0.0395	0.0506
Entamoeba histolytica	cysteine protease, putative	0.0026	0.0015	0.0161
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0058	0.0395	0.3632
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0058	0.0395	0.011
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0058	0.0395	0.0487
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0015	0.002
Trichomonas vaginalis	alpha-glucosidase, putative	0.008	0.0657	0.6143
Plasmodium falciparum	cysteine proteinase falcipain 2b	0.0058	0.0395	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0058	0.0395	0.3632
Brugia malayi	Animal haem peroxidase family protein	0.0051	0.0309	0.0395
Schistosoma mansoni	cathepsin s	0.0032	0.0078	0.0081
Entamoeba histolytica	papain family cysteine protease domain containing protein	0.0026	0.0015	0.0161
Trypanosoma cruzi	cruzipain precursor, putative	0.0032	0.0078	0.0187
Loa Loa (eye worm)	TAR-binding protein	0.0067	0.0504	0.0645
Onchocerca volvulus		0.0559	0.6407	1
Entamoeba histolytica	cysteine protease, putative	0.0058	0.0395	0.4159
Entamoeba histolytica	cysteine proteinase, putative	0.0058	0.0395	0.4159
Echinococcus granulosus	lysosomal alpha glucosidase	0.0676	0.7811	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0058	0.0395	0.3632
Onchocerca volvulus		0.0058	0.0395	0.0616
Brugia malayi	Glycosyl hydrolases family 31 protein	0.008	0.0657	0.0842
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0058	0.0395	0.3632
Trichomonas vaginalis	alpha-glucosidase, putative	0.008	0.0657	0.6143
Onchocerca volvulus		0.0058	0.0395	0.0616
Trypanosoma cruzi	sedoheptulose-1,7-bisphosphatase, putative	0.0057	0.0382	0.1086
Echinococcus multilocularis	fructose 1,6 bisphosphatase 1	0.0153	0.1537	0.1524
Plasmodium falciparum	cysteine proteinase falcipain 2a	0.0058	0.0395	1
Entamoeba histolytica	cysteine protease, putative	0.0026	0.0015	0.0161
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0058	0.0395	0.038
Echinococcus multilocularis	protein patched	0.0045	0.0236	0.0221
Leishmania major	cathepsin L-like protease	0.0058	0.0395	0.257
Trypanosoma cruzi	cysteine peptidase, putative	0.0058	0.0395	0.1123
Schistosoma mansoni	peroxidasin	0.0051	0.0309	0.0376
Entamoeba histolytica	cysteine proteinase, putative	0.0058	0.0395	0.4159
Entamoeba histolytica	cysteine proteinase, putative	0.0058	0.0395	0.4159
Loa Loa (eye worm)	hypothetical protein	0.0051	0.0309	0.0395
Trypanosoma cruzi	cysteine peptidase, putative	0.0058	0.0395	0.1123
Onchocerca volvulus		0.0058	0.0395	0.0616
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	0.0113	0.1061	0.3093
Trypanosoma brucei	glucosidase, putative	0.008	0.0657	0.2384
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0059	0.0403	1
Trichomonas vaginalis	alpha-glucosidase, putative	0.008	0.0657	0.6143
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0113	0.1061	0.1341
Echinococcus granulosus	cathepsin b	0.0308	0.3395	0.4336
Schistosoma mansoni	tar DNA-binding protein	0.0067	0.0504	0.0626
Brugia malayi	cahepsin L-like non-peptiedase homolog	0.0026	0.0015	0.002
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0058	0.0395	0.0506
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0058	0.0395	0.3632
Onchocerca volvulus		0.0051	0.0309	0.0482
Echinococcus granulosus	cysteine protease	0.0058	0.0395	0.0487
Entamoeba histolytica	cysteine proteinase 2	0.0058	0.0395	0.4159
Loa Loa (eye worm)	RNA recognition domain-containing protein domain-containing protein	0.0067	0.0504	0.0645
Trypanosoma cruzi	cysteine peptidase, putative	0.0058	0.0395	0.1123
Giardia lamblia	Cathepsin B precursor	0.0113	0.1061	1
Entamoeba histolytica	glycosyl hydrolase, family 31 protein	0.008	0.0657	0.6924
Giardia lamblia	Cathepsin B precursor	0.0113	0.1061	1
Plasmodium vivax	vivapain-1	0.0058	0.0395	1
Onchocerca volvulus	Peroxidase homolog	0.0051	0.0309	0.0482
Schistosoma mansoni	tar DNA-binding protein	0.0067	0.0504	0.0626
Loa Loa (eye worm)	hypothetical protein	0.0104	0.095	0.1216
Trypanosoma cruzi	hypothetical protein, conserved	0.008	0.0657	0.19
Trichomonas vaginalis	alpha-glucosidase, putative	0.008	0.0657	0.6143
Loa Loa (eye worm)	hypothetical protein	0.0051	0.0309	0.0395
Trypanosoma cruzi	cysteine peptidase, putative	0.0058	0.0395	0.1123
Schistosoma mansoni	aldehyde dehydrogenase	0.0059	0.0403	0.0497
Leishmania major	alpha glucosidase II subunit, putative	0.008	0.0657	0.4279
Onchocerca volvulus	Cathepsin L homolog	0.0058	0.0395	0.0616
Echinococcus multilocularis	cysteine protease	0.0058	0.0395	0.038
Echinococcus multilocularis	peroxidasin	0.0051	0.0309	0.0294
Leishmania major	cathepsin L-like protease	0.0058	0.0395	0.257
Schistosoma mansoni	cathepsin F (C01 family)	0.0058	0.0395	0.0487
Echinococcus granulosus	aldehyde dehydrogenase mitochondrial	0.0059	0.0403	0.0497
Mycobacterium leprae	PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE)	0.0025	0	0.5
Plasmodium falciparum	cysteine proteinase falcipain 3	0.0058	0.0395	1
Trichomonas vaginalis	neutral alpha-glucosidase ab precursor, putative	0.008	0.0657	0.6143
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0015	0.002
Trichomonas vaginalis	alpha-glucosidase, putative	0.008	0.0657	0.6143
Toxoplasma gondii	fructose-bisphospatase I	0.0057	0.0382	0.2412
Schistosoma mansoni	patched 1	0.0045	0.0236	0.0283
Brugia malayi	cathepsin L-like precursor	0.0026	0.0015	0.002
Echinococcus multilocularis	protein dispatched 1	0.0051	0.0311	0.0297
Leishmania major	cathepsin L-like protease	0.0058	0.0395	0.257
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0078	0.01
Onchocerca volvulus	Dual oxidase homolog	0.0051	0.0309	0.0482
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0058	0.0395	0.011
Echinococcus multilocularis	Niemann Pick C1 protein	0.0149	0.1486	0.1473
Trypanosoma cruzi	cysteine peptidase (N-terminal), putative	0.0058	0.0395	0.1123
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0015	0.002
Loa Loa (eye worm)	fructose-1,6-bisphosphatase	0.0153	0.1537	0.1967
Brugia malayi	Cathepsin L-like precursor	0.0032	0.0078	0.01
Echinococcus granulosus	cathepsin l1	0.0058	0.0395	0.0487
Trichomonas vaginalis	sucrase-isomaltase, putative	0.008	0.0657	0.6143
Trichomonas vaginalis	alpha-glucosidase, putative	0.008	0.0657	0.6143
Schistosoma mansoni	SmCB2 peptidase (C01 family)	0.0308	0.3395	0.4336
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0058	0.0395	0.3632
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0058	0.0395	0.3632
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0058	0.0395	0.011
Entamoeba histolytica	cysteine protease, putative	0.0058	0.0395	0.4159
Trypanosoma cruzi	sedoheptulose-1,7-bisphosphatase, putative	0.0057	0.0382	0.1086
Brugia malayi	Animal haem peroxidase family protein	0.0051	0.0309	0.0395
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0058	0.0395	0.3632
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0058	0.0395	0.3632
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0058	0.0395	0.3632
Entamoeba histolytica	cysteine protease, putative	0.0058	0.0395	0.4159
Brugia malayi	Animal haem peroxidase family protein	0.0051	0.0309	0.0395
Entamoeba histolytica	cysteine protease, putative	0.0058	0.0395	0.4159
Echinococcus granulosus	peroxidasin	0.0051	0.0309	0.0376
Brugia malayi	fibroinase precursor	0.0026	0.0015	0.002
Echinococcus granulosus	Protein patched homolog 1	0.0045	0.0236	0.0283
Schistosoma mansoni	alpha-glucosidase	0.0676	0.7811	1
Entamoeba histolytica	cysteine protease, putative	0.0026	0.0015	0.0161
Echinococcus granulosus	cathepsin l cysteine peptidase	0.0058	0.0395	0.0487
Loa Loa (eye worm)	hypothetical protein	0.008	0.0657	0.0842
Echinococcus multilocularis	lysosomal alpha glucosidase	0.0676	0.7811	0.7808
Trypanosoma brucei	glycosyl hydrolase-like protein	0.008	0.0657	0.2384
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0058	0.0395	0.011
Brugia malayi	Cathepsin L-like precursor	0.0058	0.0395	0.0506
Schistosoma mansoni	cathepsin F (C01 family)	0.0058	0.0395	0.0487
Trypanosoma cruzi	cysteine proteinase, putative	0.0058	0.0395	0.1123
Entamoeba histolytica	glycosyl hydrolase, family 31 protein	0.008	0.0657	0.6924
Brugia malayi	Glycosyl hydrolases family 31 protein	0.008	0.0657	0.0842
Brugia malayi	Papain family cysteine protease containing protein	0.0026	0.0015	0.002
Entamoeba histolytica	cysteine protease, putative	0.0058	0.0395	0.4159
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0058	0.0395	0.3632
Loa Loa (eye worm)	hypothetical protein	0.0051	0.0309	0.0395
Mycobacterium leprae	PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE)	0.0025	0	0.5
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0058	0.0395	0.3632
Brugia malayi	Papain family cysteine protease containing protein	0.0058	0.0395	0.0506
Brugia malayi	Cathepsin L-like cysteine proteinase	0.0026	0.0015	0.002
Trypanosoma cruzi	fructose-1,6-bisphosphatase, cytosolic, putative	0.0153	0.1537	0.4501
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0026	0.0015	0.002
Trichomonas vaginalis	conserved hypothetical protein	0.0045	0.0236	0.2107
Schistosoma mansoni	niemann-pick C1 (NPC1)	0.0106	0.0969	0.1223
Schistosoma mansoni	alpha glucosidase	0.008	0.0657	0.0824
Onchocerca volvulus		0.0058	0.0395	0.0616
Brugia malayi	RNA binding protein	0.0067	0.0504	0.0645
Echinococcus granulosus	cathepsin b	0.0308	0.3395	0.4336
Entamoeba histolytica	cysteine protease, putative	0.0058	0.0395	0.4159
Loa Loa (eye worm)	blistered cuticle protein 3	0.0051	0.0309	0.0395
Toxoplasma gondii	sedoheptulose-1,7-bisphosphatase	0.0057	0.0382	0.2412
Toxoplasma gondii	fructose-bisphospatase II	0.0153	0.1537	1
Entamoeba histolytica	cysteine proteinase, putative	0.0058	0.0395	0.4159
Trichomonas vaginalis	neutral alpha-glucosidase ab precursor, putative	0.008	0.0657	0.6143
Onchocerca volvulus	Cathepsin F homolog	0.0058	0.0395	0.0616
Echinococcus granulosus	cathepsin L cysteine protease	0.0058	0.0395	0.0487
Onchocerca volvulus		0.0058	0.0395	0.0616
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0015	0.002
Loa Loa (eye worm)	hypothetical protein	0.0308	0.3395	0.4347
Plasmodium vivax	vivapain-3	0.0058	0.0395	1
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0032	0.0078	0.01
Loa Loa (eye worm)	hypothetical protein	0.0051	0.0309	0.0395
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0058	0.0395	0.011
Brugia malayi	Papain family cysteine protease containing protein	0.0058	0.0395	0.0506
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0058	0.0395	0.011
Echinococcus multilocularis	cysteine protease	0.0058	0.0395	0.038
Loa Loa (eye worm)	ctsf protein	0.0058	0.0395	0.0506
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0058	0.0395	0.3632
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0058	0.0395	0.011
Brugia malayi	Peroxidasin	0.0051	0.0309	0.0395
Brugia malayi	cathepsin L-like cysteine proteinase	0.0026	0.0015	0.002
Loa Loa (eye worm)	hypothetical protein	0.0051	0.0309	0.0395
Leishmania major	cathepsin L-like protease	0.0058	0.0395	0.257
Onchocerca volvulus	Peroxidasin homolog	0.0051	0.0309	0.0482
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0078	0.01
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0058	0.0395	0.011
Schistosoma mansoni	peroxidasin	0.0051	0.0309	0.0376
Brugia malayi	Blistered cuticle protein 3	0.0051	0.0309	0.0395
Leishmania major	cathepsin L-like protease	0.0058	0.0395	0.257
Onchocerca volvulus	Peroxidasin homolog	0.0051	0.0309	0.0482
Brugia malayi	CHE-14 protein	0.0045	0.0236	0.0302
Echinococcus multilocularis	Niemann Pick C1 protein	0.0104	0.095	0.0936
Schistosoma mansoni	hypothetical protein	0.0043	0.0216	0.0258
Brugia malayi	Animal haem peroxidase family protein	0.0051	0.0309	0.0395
Brugia malayi	Papain family cysteine protease containing protein	0.0026	0.0015	0.002
Brugia malayi	Niemann-Pick C1 protein precursor	0.0104	0.095	0.1216
Entamoeba histolytica	cysteine proteinase 1, putative	0.0058	0.0395	0.4159
Leishmania major	cathepsin L-like protease	0.0058	0.0395	0.257
Trichomonas vaginalis	maltase-glucoamylase, putative	0.008	0.0657	0.6143
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0058	0.0395	0.3632
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0059	0.0403	1
Schistosoma mansoni	hypothetical protein	0.0043	0.0216	0.0258
Brugia malayi	Papain family cysteine protease containing protein	0.0026	0.0015	0.002
Schistosoma mansoni	aldehyde dehydrogenase	0.0059	0.0403	0.0497
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0058	0.0395	0.3632
Entamoeba histolytica	cysteine protease, putative	0.0026	0.0015	0.0161
Entamoeba histolytica	hypothetical protein	0.0026	0.0015	0.0161
Entamoeba histolytica	papain family cysteine protease domain containing protein	0.0026	0.0015	0.0161
Loa Loa (eye worm)	glycosyl hydrolase family 31 protein	0.0676	0.7811	1
Loa Loa (eye worm)	animal heme peroxidase	0.0051	0.0309	0.0395
Toxoplasma gondii	cathepsin B	0.0113	0.1061	0.6871
Onchocerca volvulus		0.0026	0.0015	0.0024
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0026	0.0015	0.002
Entamoeba histolytica	cysteine protease, putative	0.0058	0.0395	0.4159
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0058	0.0395	0.3632
Loa Loa (eye worm)	abnormal chemotaxis protein 14	0.0045	0.0236	0.0302
Trichomonas vaginalis	maltase-glucoamylase, putative	0.008	0.0657	0.6143
Echinococcus granulosus	Niemann Pick C1 protein	0.0149	0.1486	0.1887
Trypanosoma cruzi	glycosyl hydrolase-like protein, putative	0.008	0.0657	0.19
Brugia malayi	Cathepsin L-like precursor	0.0026	0.0015	0.002
Loa Loa (eye worm)	hypothetical protein	0.0051	0.0309	0.0395
Schistosoma mansoni	tar DNA-binding protein	0.0067	0.0504	0.0626
Brugia malayi	Cathepsin L-like precursor	0.0058	0.0395	0.0506
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0058	0.0395	0.011
Brugia malayi	Cathepsin L-like precursor	0.0026	0.0015	0.002
Loa Loa (eye worm)	hypothetical protein	0.0055	0.0356	0.0456
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0058	0.0395	0.3632
Echinococcus multilocularis	cathepsin L	0.0058	0.0395	0.038
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0078	0.01
Plasmodium vivax	vivapain-2	0.0058	0.0395	1
Trichomonas vaginalis	neutral alpha-glucosidase ab precursor, putative	0.008	0.0657	0.6143
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	0.0308	0.3395	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0058	0.0395	0.011
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0015	0.002
Brugia malayi	cathepsin F-like cysteine proteinase	0.0032	0.0078	0.01
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0058	0.0395	0.3632
Echinococcus multilocularis	tar DNA binding protein	0.0067	0.0504	0.0489
Trypanosoma cruzi	cysteine protease, putative	0.0058	0.0395	0.1123
Entamoeba histolytica	cysteine protease, putative	0.0058	0.0395	0.4159
Onchocerca volvulus	Peroxidase homolog	0.0051	0.0309	0.0482
Loa Loa (eye worm)	cysteine proteinase cathepsin Z	0.0026	0.0015	0.002
Plasmodium vivax	unspecified product	0.0058	0.0395	1
Loa Loa (eye worm)	cathepsin B	0.0113	0.1061	0.1358
Entamoeba histolytica	cysteine protease, putative	0.0026	0.0015	0.0161
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0058	0.0395	0.0487
Entamoeba histolytica	cysteine protease, putative	0.0058	0.0395	0.4159
Echinococcus granulosus	fructose 16 bisphosphatase 1	0.0153	0.1537	0.1951
Brugia malayi	cathepsin L-like cysteine proteinase, identical	0.0032	0.0078	0.01
Trypanosoma cruzi	cysteine peptidase, putative	0.0058	0.0395	0.1123
Trypanosoma brucei	cysteine peptidase C (CPC)	0.0113	0.1061	0.5876
Brugia malayi	cathepsin F-like cysteine proteinase	0.0026	0.0015	0.002
Onchocerca volvulus		0.0051	0.0309	0.0482
Loa Loa (eye worm)	fibroinase	0.0058	0.0395	0.0506
Plasmodium vivax	unspecified product	0.0032	0.0078	0.1664
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0058	0.0395	0.3632
Loa Loa (eye worm)	cysteine protease	0.0058	0.0395	0.0506
Loa Loa (eye worm)	hypothetical protein	0.0045	0.0236	0.0302
Loa Loa (eye worm)	animal heme peroxidase	0.0051	0.0309	0.0395
Loa Loa (eye worm)	glycosyl hydrolase family 31 protein	0.008	0.0657	0.0842
Onchocerca volvulus		0.0058	0.0395	0.0616
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0058	0.0395	0.038
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0015	0.002
Trypanosoma cruzi	cysteine peptidase, putative	0.0032	0.0078	0.0187
Echinococcus granulosus	tar DNA binding protein	0.0067	0.0504	0.0626
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0058	0.0395	0.3632
Trichomonas vaginalis	neutral alpha-glucosidase ab precursor, putative	0.008	0.0657	0.6143
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0058	0.0395	0.011
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0058	0.0395	0.011
Entamoeba histolytica	cysteine proteinase, putative	0.0026	0.0015	0.0161
Brugia malayi	TAR-binding protein	0.0067	0.0504	0.0645
Brugia malayi	hypothetical protein	0.0051	0.0309	0.0395
Entamoeba histolytica	Niemann-Pick C1 protein, putative	0.0104	0.095	1
Schistosoma mansoni	fructose-16-bisphosphatase-related	0.0153	0.1537	0.1951
Mycobacterium tuberculosis	Probable aldehyde dehydrogenase	0.0059	0.0403	1
Onchocerca volvulus	Cathepsin L homolog	0.0026	0.0015	0.0024
Loa Loa (eye worm)	animal heme peroxidase	0.0051	0.0309	0.0395
Brugia malayi	RNA recognition motif domain containing protein	0.0067	0.0504	0.0645
Echinococcus granulosus	Niemann Pick C1 protein	0.0104	0.095	0.1198
Leishmania major		0.0153	0.1537	1
Giardia lamblia	Cathepsin B precursor	0.0113	0.1061	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0058	0.0395	0.011
Echinococcus multilocularis	cathepsin L cysteine protease	0.0058	0.0395	0.038
Schistosoma mansoni	hypothetical protein	0.0043	0.0216	0.0258
Onchocerca volvulus		0.0026	0.0015	0.0024
Brugia malayi	Glycosyl hydrolases family 31 protein	0.0676	0.7811	1
Entamoeba histolytica	cysteine proteinase, putative	0.0058	0.0395	0.4159
Loa Loa (eye worm)	hypothetical protein	0.0051	0.0309	0.0395
Schistosoma mansoni	alpha-glucosidase	0.0676	0.7811	1
Brugia malayi	fructose-1,6-bisphosphatase	0.0153	0.1537	0.1967
Trypanosoma cruzi	cysteine proteinase, putative	0.0058	0.0395	0.1123
Echinococcus granulosus	cathepsin L cysteine proteinase	0.0058	0.0395	0.0487
Toxoplasma gondii	cathepsin CPL	0.0058	0.0395	0.2495
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0058	0.0395	0.3632
Brugia malayi	Animal haem peroxidase family protein	0.0051	0.0309	0.0395
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0015	0.002
Brugia malayi	Cathepsin L-like precursor	0.0058	0.0395	0.0506
Echinococcus multilocularis	cathepsin L cysteine protease	0.0058	0.0395	0.038
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0308	0.3395	0.4336

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

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Bibliographic References

No literature references available for this target.

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Detailed information for compound 806577