Detailed information for compound 807138

Basic information

Technical information
  • TDR Targets ID: 807138
  • Name: 2,6-ditert-butyl-4-(2,3-dihydro-1H-perimidin- 2-yl)phenol
  • MW: 374.519 | Formula: C25H30N2O
  • H donors: 3 H acceptors: 1 LogP: 7.53 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: CC(c1cc(cc(c1O)C(C)(C)C)C1Nc2cccc3c2c(N1)ccc3)(C)C
  • InChi: 1S/C25H30N2O/c1-24(2,3)17-13-16(14-18(22(17)28)25(4,5)6)23-26-19-11-7-9-15-10-8-12-20(27-23)21(15)19/h7-14,23,26-28H,1-6H3
  • InChiKey: WBSRWPYIVUJCCR-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • Oprea1_102723
  • 2,6-Di-tert-butyl-4-(2,3-dihydro-1H-perimidin-2-yl)-phenol
  • BAS 00589219
  • ZINC01833114
  • BIM-0006167.P001
  • CBMicro_006088
  • ST041327
  • AG-690/11480846
  • Oprea1_838578

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0044 0.0972 0.1255
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0059 0.1443 0.1443
Trypanosoma cruzi metacaspase 5, putative 0.003 0.0552 0.066
Echinococcus multilocularis phosphoglycerate kinase 1 0.019 0.5377 0.5377
Mycobacterium tuberculosis Probable phosphoglycerate kinase Pgk 0.019 0.5377 1
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0014 0.008 0.008
Plasmodium falciparum ATP-dependent DNA helicase Q1 0.0021 0.0289 0.0461
Trichomonas vaginalis chromobox protein, putative 0.0047 0.1072 0.1928
Schistosoma mansoni hypothetical protein 0.0189 0.5352 0.5352
Onchocerca volvulus 0.0034 0.0689 0.089
Leishmania major DNA polymerase kappa, putative 0.0067 0.1665 0.2814
Trichomonas vaginalis conserved hypothetical protein 0.003 0.0552 0.0953
Trichomonas vaginalis CAMK family protein kinase 0.0105 0.2833 0.5231
Mycobacterium ulcerans DNA polymerase IV 0.0089 0.2336 0.4114
Trichomonas vaginalis conserved hypothetical protein 0.0031 0.0589 0.1023
Brugia malayi hypothetical protein 0.0018 0.0207 0.0267
Trypanosoma brucei metacaspase 5, putative 0.003 0.0552 0.066
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0053 0.1249 0.2009
Echinococcus multilocularis chromobox protein 2 0.0013 0.0044 0.0044
Giardia lamblia Kinase, PLK 0.0105 0.2833 0.5076
Echinococcus multilocularis caspase 0.003 0.0552 0.0552
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative 0.0027 0.0474 0.051
Trichomonas vaginalis mercuric reductase, putative 0.0018 0.0211 0.0314
Brugia malayi hypothetical protein 0.0013 0.0044 0.0056
Schistosoma mansoni transcription factor LCR-F1 0.004 0.0869 0.0869
Trichomonas vaginalis DNA helicase recq, putative 0.0051 0.1184 0.2137
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0021 0.0289 0.0461
Leishmania major metacaspase, putative 0.003 0.0552 0.066
Trypanosoma cruzi phosphoglycerate kinase, putative 0.007 0.1759 0.2997
Echinococcus granulosus beta arrestin 1 0.0038 0.0819 0.0819
Trypanosoma brucei DNA polymerase kappa, putative 0.0089 0.2336 0.4114
Echinococcus granulosus caspase 8 0.003 0.0552 0.0552
Plasmodium falciparum phosphoglycerate kinase 0.019 0.5377 1
Plasmodium falciparum glutathione reductase 0.0053 0.1249 0.226
Trichomonas vaginalis importin beta-1, putative 0.0026 0.0446 0.0754
Plasmodium falciparum ataxin-2 like protein, putative 0.0028 0.0507 0.0869
Schistosoma mansoni caspase-7 (C14 family) 0.003 0.0552 0.0552
Echinococcus multilocularis histone lysine N methyltransferase, H3 lysine 36 0.0012 0.0017 0.0017
Trypanosoma cruzi DNA polymerase kappa, putative 0.0089 0.2336 0.4114
Trichomonas vaginalis CAMK family protein kinase 0.0105 0.2833 0.5231
Schistosoma mansoni beta-arrestin 1 0.0038 0.0819 0.0819
Echinococcus multilocularis dna polymerase eta 0.0088 0.2299 0.2299
Trypanosoma brucei DNA polymerase kappa, putative 0.0048 0.1107 0.1734
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0067 0.1665 0.2814
Loa Loa (eye worm) hypothetical protein 0.0154 0.4291 0.4291
Brugia malayi polk-prov protein 0.0048 0.1107 0.1429
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0018 0.0211 0.0314
Brugia malayi hypothetical protein 0.0028 0.0507 0.0655
Echinococcus granulosus geminin 0.0189 0.5352 0.5352
Leishmania major DNA polymerase eta, putative 0.0047 0.1069 0.1662
Toxoplasma gondii thioredoxin reductase 0.0053 0.1249 0.226
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0013 0.0044 0.00000000061472
Loa Loa (eye worm) hypothetical protein 0.0013 0.0044 0.0044
Brugia malayi Associated with TFs and helicases family protein 0.0013 0.0044 0.0056
Trichomonas vaginalis CAMK family protein kinase 0.0052 0.1231 0.2227
Brugia malayi Protein cec-1. 0.0013 0.0044 0.0056
Loa Loa (eye worm) hypothetical protein 0.0021 0.0289 0.0289
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0018 0.0211 0.0314
Plasmodium falciparum metacaspase 1 0.003 0.0552 0.0953
Mycobacterium tuberculosis Putative ferredoxin reductase 0.012 0.3283 0.5947
Plasmodium falciparum thioredoxin reductase 0.0053 0.1249 0.226
Schistosoma mansoni chromobox protein-related (chromobox 1) (heterochromatin 1) 0.0013 0.0044 0.0044
Trypanosoma brucei importin beta-1 subunit, putative 0.0032 0.0629 0.0809
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0105 0.2833 0.2833
Onchocerca volvulus Serine\/threonine kinase homolog 0.0105 0.2833 0.3658
Giardia lamblia DNA damage repair protein 0.0018 0.0214 0.0006
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.003 0.0552 0.0953
Trypanosoma brucei DNA polymerase kappa, putative 0.0089 0.2336 0.4114
Schistosoma mansoni chromobox protein 0.0078 0.2001 0.2001
Trypanosoma cruzi metacaspase, putative 0.003 0.0552 0.066
Trichomonas vaginalis chromobox protein, putative 0.0047 0.1072 0.1928
Loa Loa (eye worm) hypothetical protein 0.003 0.0552 0.0552
Trypanosoma cruzi importin beta-1 subunit, putative 0.0026 0.0446 0.0455
Echinococcus granulosus beta arrestin 1 0.004 0.0872 0.0872
Echinococcus granulosus histone lysine N methyltransferase NSD3 0.0037 0.0761 0.0761
Entamoeba histolytica phosphoglycerate kinase, putative 0.019 0.5377 1
Schistosoma mansoni DNA polymerase IV / kappa 0.0018 0.0214 0.0214
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0034 0.0678 0.119
Mycobacterium tuberculosis Probable dehydrogenase 0.012 0.3283 0.5947
Entamoeba histolytica chromodomain-helicase-DNA-binding protein, putative 0.0013 0.0044 0.00000000061472
Trypanosoma brucei DNA damage repair protein, putative 0.0018 0.0214 0.0006
Leishmania major DNA polymerase kappa, putative 0.0018 0.0214 0.0006
Schistosoma mansoni SET domain protein 0.0012 0.0017 0.0017
Echinococcus granulosus caspase 0.003 0.0552 0.0552
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0059 0.1443 0.1443
Trypanosoma brucei importin beta-1 subunit, putative 0.0032 0.0629 0.0809
Leishmania major phosphoglycerate kinase B, cytosolic 0.019 0.5377 1
Echinococcus multilocularis beta arrestin 1 0.0038 0.0819 0.0819
Plasmodium vivax importin-beta 2, putative 0.0032 0.0629 0.1098
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.003 0.0552 0.0953
Entamoeba histolytica hypothetical protein 0.0013 0.0044 0.00000000061472
Trypanosoma brucei metacaspase MCA3 0.003 0.0552 0.066
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0013 0.0044 0.00000000061472
Echinococcus granulosus chromobox protein 1 0.0078 0.2001 0.2001
Brugia malayi hypothetical protein 0.0098 0.262 0.3384
Trypanosoma brucei DNA polymerase kappa, putative 0.0089 0.2336 0.4114
Loa Loa (eye worm) hypothetical protein 0.0013 0.0044 0.0044
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0343 1 1
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.003 0.0552 0.0953
Mycobacterium ulcerans phosphoglycerate kinase 0.019 0.5377 1
Trypanosoma cruzi PAB1-binding protein , putative 0.0028 0.0507 0.0573
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative 0.0034 0.069 0.1213
Loa Loa (eye worm) CHromoDomain protein family member 0.0013 0.0044 0.0044
Brugia malayi Probable beta-arrestin 0.004 0.0872 0.1126
Echinococcus granulosus histone lysine N methyltransferase H3 lysine 36 0.0012 0.0017 0.0017
Trypanosoma brucei DNA polymerase kappa, putative 0.0089 0.2336 0.4114
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0013 0.004 0.004
Echinococcus granulosus Chromo domain 0.0013 0.0044 0.0044
Echinococcus granulosus dna polymerase eta 0.0088 0.2299 0.2299
Plasmodium falciparum metacaspase-like protein 0.003 0.0552 0.0953
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0018 0.0211 0.0314
Brugia malayi MH2 domain containing protein 0.0133 0.3671 0.474
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.003 0.0552 0.0953
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0089 0.2336 0.4299
Echinococcus multilocularis dna polymerase kappa 0.0089 0.2336 0.2336
Trypanosoma cruzi DNA polymerase eta, putative 0.0047 0.1069 0.1662
Plasmodium falciparum chromodomain-helicase-DNA-binding protein 1 homolog, putative 0.0013 0.0044 0.00000000061472
Loa Loa (eye worm) hypothetical protein 0.0013 0.0044 0.0044
Onchocerca volvulus 0.0013 0.0044 0.0056
Loa Loa (eye worm) pax transcription factor protein 2 0.0268 0.7745 0.7745
Loa Loa (eye worm) hypothetical protein 0.003 0.0552 0.0552
Schistosoma mansoni blooms syndrome DNA helicase 0.004 0.0863 0.0863
Brugia malayi Bloom's syndrome protein homolog 0.0051 0.1184 0.1528
Loa Loa (eye worm) hypothetical protein 0.0013 0.0044 0.0044
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.003 0.0552 0.0953
Schistosoma mansoni chromobox protein 0.0078 0.2001 0.2001
Echinococcus multilocularis histone lysine N methyltransferase NSD3 0.0037 0.0761 0.0761
Trichomonas vaginalis DNA polymerase eta, putative 0.0089 0.2336 0.4299
Plasmodium vivax phosphoglycerate kinase, putative 0.019 0.5377 1
Plasmodium falciparum ataxin-2 like protein, putative 0.0028 0.0507 0.0869
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.003 0.0552 0.0953
Trypanosoma brucei DNA polymerase kappa, putative 0.0048 0.1111 0.1743
Echinococcus granulosus chromodomain helicase DNA binding protein 1 0.0013 0.0044 0.0044
Trypanosoma cruzi phosphoglycerate kinase, putative 0.019 0.5377 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0089 0.2336 0.4114
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.004 0.0869 0.0869
Onchocerca volvulus 0.0014 0.008 0.0104
Loa Loa (eye worm) hypothetical protein 0.0032 0.0629 0.0629
Mycobacterium tuberculosis Probable oxidoreductase 0.0134 0.3688 0.673
Plasmodium vivax hypothetical protein, conserved 0.003 0.0552 0.0953
Trypanosoma cruzi hypothetical protein, conserved 0.0018 0.0214 0.0006
Trypanosoma brucei polo-like protein kinase 0.0105 0.2833 0.5076
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0047 0.1072 0.1384
Leishmania major importin beta-1 subunit, putative 0.0026 0.0446 0.0455
Trichomonas vaginalis conserved hypothetical protein 0.0044 0.0972 0.1741
Echinococcus multilocularis caspase 2 0.003 0.0552 0.0552
Brugia malayi Thioredoxin reductase 0.0053 0.1249 0.1612
Loa Loa (eye worm) hypothetical protein 0.0098 0.262 0.262
Plasmodium falciparum glutathione reductase 0.0018 0.0211 0.0314
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0013 0.0044 0.00000000061472
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0021 0.0289 0.0373
Trypanosoma cruzi hypothetical protein, conserved 0.0018 0.0214 0.0006
Echinococcus granulosus phosphoglycerate kinase 1 0.019 0.5377 0.5377
Onchocerca volvulus 0.0268 0.7745 1
Brugia malayi Cell death protein 3 precursor 0.003 0.0552 0.0713
Echinococcus multilocularis importin subunit beta 1 0.0032 0.0629 0.0629
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0018 0.0211 0.0314
Schistosoma mansoni importin beta-1 0.0032 0.0629 0.0629
Trypanosoma brucei DNA polymerase kappa, putative 0.0089 0.2336 0.4114
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0105 0.2833 0.2833
Echinococcus multilocularis ATP dependent DNA helicase Q5 0.0021 0.0289 0.0289
Plasmodium vivax ataxin-2 like protein, putative 0.0028 0.0507 0.0869
Trypanosoma brucei DNA polymerase kappa, putative 0.0067 0.1665 0.2814
Loa Loa (eye worm) thioredoxin reductase 0.0053 0.1249 0.1249
Schistosoma mansoni hypothetical protein 0.004 0.0869 0.0869
Trypanosoma brucei Metacaspase-4 0.003 0.0552 0.066
Trypanosoma brucei phosphoglycerate kinase 0.007 0.1759 0.2997
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0018 0.0211 0.0314
Echinococcus granulosus chromodomain helicase DNA binding protein 4 0.0013 0.0044 0.0044
Brugia malayi Phosphoglycerate kinase 0.019 0.5377 0.6943
Leishmania major DNA damage repair protein, putative 0.0018 0.0214 0.0006
Schistosoma mansoni DNA polymerase eta 0.0088 0.2299 0.2299
Trypanosoma cruzi polo-like protein kinase, putative 0.0105 0.2833 0.5076
Loa Loa (eye worm) RecQ helicase 0.0051 0.1184 0.1184
Schistosoma mansoni hypothetical protein 0.0013 0.004 0.004
Entamoeba histolytica recQ family helicase, putative 0.0027 0.0474 0.0807
Trypanosoma cruzi DNA polymerase kappa, putative 0.0089 0.2336 0.4114
Brugia malayi Importin beta-1 subunit 0.0032 0.0629 0.0812
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.012 0.3283 0.5947
Trypanosoma brucei phosphoglycerate kinase 0.019 0.5377 1
Trichomonas vaginalis DNA helicase recq, putative 0.0027 0.0474 0.0807
Trypanosoma brucei unspecified product 0.0041 0.089 0.1314
Trypanosoma brucei unspecified product 0.0081 0.2115 0.3685
Trichomonas vaginalis conserved hypothetical protein 0.003 0.0552 0.0953
Echinococcus multilocularis chromobox protein 1 0.0078 0.2001 0.2001
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0021 0.0289 0.0461
Trichomonas vaginalis chromobox protein, putative 0.0078 0.2001 0.3669
Schistosoma mansoni serine/threonine protein kinase 0.0105 0.2833 0.2833
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0018 0.0211 0.0211
Trypanosoma brucei DNA polymerase IV, putative 0.0089 0.2336 0.4114
Echinococcus multilocularis ATP dependent DNA helicase Q1 0.0021 0.0289 0.0289
Leishmania major DNA polymerase eta, putative 0.0088 0.2299 0.4041
Mycobacterium ulcerans DNA polymerase IV 0.0089 0.2336 0.4114
Trypanosoma cruzi trypanothione reductase, putative 0.0053 0.1249 0.2009
Brugia malayi Valyl-tRNA synthetase 0.0013 0.0044 0.0056
Schistosoma mansoni subfamily C14A unassigned peptidase (C14 family) 0.003 0.0552 0.0552
Schistosoma mansoni phosphoglycerate kinase 0.019 0.5377 0.5377
Entamoeba histolytica serine/threonine protein kinase, putative 0.0105 0.2833 0.5231
Trichomonas vaginalis conserved hypothetical protein 0.003 0.0552 0.0953
Plasmodium vivax DNA repair protein REV1, putative 0.0018 0.0214 0.0319
Trypanosoma brucei hypothetical protein, conserved 0.0018 0.0214 0.0006
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0013 0.004 0.004
Loa Loa (eye worm) hypothetical protein 0.0098 0.262 0.262
Schistosoma mansoni chromobox protein 0.0013 0.0044 0.0044
Trichomonas vaginalis glutathione reductase, putative 0.0018 0.0211 0.0314
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0013 0.0044 0.00000000061472
Leishmania major phosphoglycerate kinase C, glycosomal 0.019 0.5377 1
Loa Loa (eye worm) hypothetical protein 0.0013 0.0044 0.0044
Trichomonas vaginalis conserved hypothetical protein 0.003 0.0552 0.0953
Brugia malayi M-phase phosphoprotein, mpp8 0.0013 0.0044 0.0056
Trypanosoma cruzi DNA polymerase kappa, putative 0.0089 0.2336 0.4114
Schistosoma mansoni chromodomain helicase DNA binding protein 0.0013 0.0044 0.0044
Loa Loa (eye worm) ATP-dependent DNA helicase 0.0021 0.0289 0.0289
Trypanosoma cruzi metacaspase 5, putative 0.003 0.0552 0.066
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0013 0.0044 0.00000000061472
Schistosoma mansoni eyes absent homolog 0.0098 0.262 0.262
Schistosoma mansoni chromobox protein 0.0013 0.0044 0.0044
Plasmodium vivax metacaspase 1, putative 0.003 0.0552 0.0953
Trypanosoma brucei hypothetical protein, conserved 0.0018 0.0214 0.0006
Trichomonas vaginalis CAMK family protein kinase 0.0105 0.2833 0.5231
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0134 0.3688 0.673
Echinococcus multilocularis snurportin 1 0.0343 1 1
Echinococcus granulosus chromobox protein 1 0.0078 0.2001 0.2001
Loa Loa (eye worm) hypothetical protein 0.0028 0.0507 0.0507
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0013 0.0044 0.00000000061472
Entamoeba histolytica hypothetical protein 0.004 0.0869 0.1548
Trypanosoma cruzi DNA damage repair protein, putative 0.0018 0.0214 0.0006
Echinococcus granulosus caspase 3 apoptosis cysteine peptidase 0.003 0.0552 0.0552
Trypanosoma cruzi phosphoglycerate kinase, putative 0.007 0.1759 0.2997
Trypanosoma brucei DNA polymerase IV, putative 0.0089 0.2336 0.4114
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.012 0.3283 0.5947
Trypanosoma cruzi metacaspase, putative 0.003 0.0552 0.066
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.003 0.0552 0.0953
Echinococcus granulosus caspase 2 0.003 0.0552 0.0552
Trypanosoma brucei DNA polymerase kappa, putative 0.0089 0.2336 0.4114
Trypanosoma cruzi 3-phosphoglycerate kinase, glycosomal 0.007 0.1759 0.2997
Trypanosoma cruzi DNA polymerase eta, putative 0.0088 0.2299 0.4041
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0018 0.0211 0.0211
Trypanosoma brucei DNA polymerase IV, putative 0.0081 0.2115 0.3685
Brugia malayi Pax transcription factor protein 2 0.0268 0.7745 1
Trypanosoma cruzi DNA polymerase kappa, putative 0.0089 0.2336 0.4114
Trypanosoma brucei DNA polymerase eta, putative 0.0088 0.2299 0.4041
Trichomonas vaginalis CAMK family protein kinase 0.0105 0.2833 0.5231
Echinococcus multilocularis thioredoxin glutathione reductase 0.0053 0.1249 0.1249
Schistosoma mansoni hypothetical protein 0.0189 0.5352 0.5352
Trypanosoma brucei unspecified product 0.0041 0.089 0.1314
Leishmania major hypothetical protein, conserved 0.0028 0.0507 0.0573
Trypanosoma brucei DNA damage repair protein, putative 0.0018 0.0214 0.0006
Trypanosoma brucei metacaspase MCA2 0.003 0.0552 0.066
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.012 0.3283 0.5947
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0013 0.0065 0.0084
Echinococcus multilocularis chromobox protein 1 0.0078 0.2001 0.2001
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.004 0.0869 0.0869
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0059 0.1443 0.1443
Onchocerca volvulus Cell death protein 3 homolog 0.003 0.0552 0.0713
Schistosoma mansoni terminal deoxycytidyl transferase 0.0059 0.1443 0.1443
Brugia malayi glutathione reductase 0.0053 0.1249 0.1612
Entamoeba histolytica chromodomain-helicase-DNA-binding protein, putative 0.0013 0.0044 0.00000000061472
Toxoplasma gondii phosphoglycerate kinase PGKI 0.019 0.5377 1
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0018 0.0211 0.0272
Brugia malayi CHD4 protein 0.0013 0.0044 0.0056
Loa Loa (eye worm) hypothetical protein 0.0088 0.2299 0.2299
Echinococcus granulosus importin subunit beta 1 0.0032 0.0629 0.0629
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0021 0.0289 0.0373
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0018 0.0211 0.0211
Trichomonas vaginalis phosphoglycerate kinase, putative 0.019 0.5377 1
Plasmodium falciparum DNA repair protein REV1, putative 0.0018 0.0214 0.0319
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0013 0.0044 0.00000000061472
Trypanosoma brucei DNA polymerase kappa, putative 0.0089 0.2336 0.4114
Echinococcus multilocularis chromodomain helicase DNA binding protein 4 0.0013 0.0044 0.0044
Loa Loa (eye worm) hypothetical protein 0.0034 0.0689 0.0689
Toxoplasma gondii NADPH-glutathione reductase 0.0018 0.0211 0.0314
Echinococcus multilocularis Chromo domain 0.0013 0.0044 0.0044
Brugia malayi mucosa associated lymphoid tissue lymphoma translocation protein 1 0.003 0.0552 0.0713
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0018 0.0214 0.0319
Trypanosoma brucei DNA polymerase kappa, putative 0.0048 0.1107 0.1734
Brugia malayi Heterochromatin protein 1 0.0078 0.2001 0.2583
Mycobacterium tuberculosis Probable reductase 0.012 0.3283 0.5947
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0134 0.3688 0.673
Leishmania major PAS-domain containing phosphoglycerate kinase, putative 0.007 0.1759 0.2997
Echinococcus granulosus ATP dependent DNA helicase Q5 0.0021 0.0289 0.0289
Trichomonas vaginalis conserved hypothetical protein 0.0044 0.0972 0.1741
Echinococcus granulosus dna polymerase kappa 0.0089 0.2336 0.2336
Trypanosoma brucei DNA polymerase kappa, putative 0.0089 0.2336 0.4114
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0013 0.0044 0.00000000061472
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.003 0.0552 0.0953
Trypanosoma brucei phosphoglycerate kinase, putative 0.007 0.1759 0.2997
Trichomonas vaginalis CAMK family protein kinase 0.0052 0.1231 0.2227
Brugia malayi Type III restriction enzyme, res subunit family protein 0.0013 0.0044 0.0056
Schistosoma mansoni caspase-7 (C14 family) 0.003 0.0552 0.0552
Giardia lamblia Sgs1 DNA helicase, putative 0.0021 0.0289 0.0152
Wolbachia endosymbiont of Brugia malayi phosphoglycerate kinase 0.019 0.5377 1
Echinococcus granulosus Chromobox protein 3 0.0013 0.0044 0.0044
Loa Loa (eye worm) hypothetical protein 0.0013 0.0044 0.0044
Brugia malayi ImpB/MucB/SamB family protein 0.0088 0.2299 0.2968
Brugia malayi RNA, U transporter 1 0.0091 0.2415 0.3118
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0027 0.0474 0.051
Plasmodium falciparum importin beta, putative 0.0032 0.0629 0.1098
Plasmodium falciparum thioredoxin reductase 0.0018 0.0211 0.0314
Plasmodium vivax thioredoxin reductase, putative 0.0053 0.1249 0.226
Trichomonas vaginalis CAMK family protein kinase 0.0105 0.2833 0.5231
Schistosoma mansoni chromodomain helicase DNA binding protein 0.0013 0.0044 0.0044
Trichomonas vaginalis CAMK family protein kinase 0.0105 0.2833 0.5231
Toxoplasma gondii phosphoglycerate kinase PGKII 0.019 0.5377 1
Trypanosoma brucei phosphoglycerate kinase 0.019 0.5377 1
Loa Loa (eye worm) hypothetical protein 0.019 0.5377 0.5377
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0013 0.0065 0.0084
Mycobacterium tuberculosis Conserved hypothetical protein 0.0059 0.1443 0.2385
Loa Loa (eye worm) heterochromatin protein 1 0.0078 0.2001 0.2001
Entamoeba histolytica hypothetical protein 0.004 0.0869 0.1548
Loa Loa (eye worm) glutathione reductase 0.0053 0.1249 0.1249
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0013 0.0044 0.00000000061472
Trichomonas vaginalis phosphoglycerate kinase, putative 0.019 0.5377 1
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0013 0.0044 0.00000000061472
Schistosoma mansoni caspase-3 (C14 family) 0.003 0.0552 0.0552
Trypanosoma cruzi metacaspase, putative 0.003 0.0552 0.066
Trypanosoma cruzi metacaspase, putative 0.003 0.0552 0.066
Entamoeba histolytica hypothetical protein 0.004 0.0869 0.1548
Echinococcus multilocularis caspase 3, apoptosis cysteine peptidase 0.003 0.0552 0.0552
Echinococcus multilocularis chromodomain helicase DNA binding protein 1 0.0013 0.0044 0.0044
Echinococcus multilocularis beta arrestin 1 0.004 0.0872 0.0872
Loa Loa (eye worm) hypothetical protein 0.004 0.0872 0.0872
Trypanosoma brucei DNA polymerase kappa, putative 0.0048 0.1111 0.1743
Schistosoma mansoni beta-arrestin 1 0.004 0.0872 0.0872
Schistosoma mansoni SET domain protein 0.0037 0.0761 0.0761
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0013 0.0044 0.00000000061472
Toxoplasma gondii LsmAD domain-containing protein 0.0028 0.0507 0.0869
Trypanosoma cruzi PAB1-binding protein , putative 0.0028 0.0507 0.0573
Trichomonas vaginalis conserved hypothetical protein 0.003 0.0552 0.0953
Brugia malayi serine/threonine-protein kinase plk-2 0.0105 0.2833 0.3658
Trypanosoma brucei trypanothione reductase 0.0053 0.1249 0.2009
Loa Loa (eye worm) hypothetical protein 0.0013 0.0044 0.0044
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0105 0.2833 0.2833
Brugia malayi chromobox protein homolog 3 0.0044 0.0972 0.1255
Trypanosoma brucei chrX additional, unordered contigs 0.0018 0.0214 0.0006
Echinococcus granulosus ATP dependent DNA helicase Q1 0.0021 0.0289 0.0289
Schistosoma mansoni kinase 0.0054 0.1273 0.1273
Echinococcus multilocularis geminin 0.0189 0.5352 0.5352
Trichomonas vaginalis conserved hypothetical protein 0.003 0.0552 0.0953
Schistosoma mansoni hypothetical protein 0.0013 0.0044 0.0044
Giardia lamblia DINP protein human, muc B family 0.0067 0.1665 0.2814
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0013 0.0044 0.00000000061472
Entamoeba histolytica hypothetical protein 0.0026 0.0446 0.0754
Trypanosoma cruzi PAS-domain containing phosphoglycerate kinase, putative 0.007 0.1759 0.2997
Trypanosoma cruzi DNA damage repair protein, putative 0.0018 0.0214 0.0006
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0026 0.0446 0.0754
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.003 0.0552 0.0953
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0047 0.1069 0.1923
Onchocerca volvulus 0.0013 0.0044 0.0056
Echinococcus granulosus chromobox protein 2 0.0013 0.0044 0.0044
Toxoplasma gondii BRCA1 C Terminus (BRCT) domain-containing protein 0.0026 0.0435 0.0735
Mycobacterium ulcerans hypothetical protein 0.0018 0.0214 0.0006
Treponema pallidum phosphoglycerate kinase 0.019 0.5377 1
Plasmodium vivax glutathione reductase, putative 0.0053 0.1249 0.226
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0105 0.2833 0.5076
Trichomonas vaginalis DNA helicase recq1, putative 0.0051 0.1184 0.2137
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0013 0.0044 0.00000000061472
Brugia malayi ImpB/MucB/SamB family protein 0.0059 0.1443 0.1863
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0059 0.1443 0.1443
Trichomonas vaginalis conserved hypothetical protein 0.0031 0.0589 0.1023
Echinococcus granulosus bloom syndrome protein 0.0051 0.1184 0.1184
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.003 0.0552 0.0953
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0067 0.1665 0.2814
Echinococcus granulosus beta arrestin 1 0.004 0.0872 0.0872
Schistosoma mansoni hypothetical protein 0.0343 1 1
Loa Loa (eye worm) hypothetical protein 0.0048 0.1107 0.1107
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.0027 0.0474 0.051
Chlamydia trachomatis phosphoglycerate kinase 0.019 0.5377 1
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.003 0.0552 0.0953
Echinococcus multilocularis caspase 8 0.003 0.0552 0.0552
Trypanosoma cruzi phosphoglycerate kinase, putative 0.019 0.5377 1
Loa Loa (eye worm) hypothetical protein 0.0044 0.0972 0.0972
Schistosoma mansoni phosphoglycerate kinase 0.019 0.5377 0.5377
Trypanosoma brucei PAB1-binding protein , putative 0.0028 0.0507 0.0573
Trypanosoma brucei metacaspase 0.003 0.0552 0.066
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.003 0.0552 0.0953
Toxoplasma gondii chromodomain helicase DNA binding protein CHD1/SWI2/SNF2 0.0013 0.0044 0.00000000061472
Schistosoma mansoni DNA helicase recq5 0.0021 0.0289 0.0289
Toxoplasma gondii HEAT repeat-containing protein 0.0032 0.0629 0.1098
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0134 0.3688 0.1931
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0044 0.0999 0.1791
Trypanosoma cruzi polo-like protein kinase, putative 0.0105 0.2833 0.5076
Trichomonas vaginalis CAMK family protein kinase 0.0105 0.2833 0.5231
Entamoeba histolytica hypothetical protein 0.004 0.0869 0.1548
Echinococcus multilocularis Chromobox protein 3 0.0013 0.0044 0.0044
Entamoeba histolytica deoxycytidyl transferase, putative 0.0059 0.1443 0.2624
Schistosoma mansoni chromobox protein-related (chromobox 1) (heterochromatin 1) 0.0013 0.0044 0.0044
Echinococcus multilocularis beta arrestin 1 0.004 0.0872 0.0872
Trypanosoma brucei DNA polymerase kappa, putative 0.0048 0.1111 0.1743
Leishmania major trypanothione reductase 0.0053 0.1249 0.2009
Echinococcus multilocularis bloom syndrome protein 0.0051 0.1184 0.1184
Trypanosoma cruzi PAS-domain containing phosphoglycerate kinase, putative 0.007 0.1759 0.2997
Loa Loa (eye worm) transcription factor SMAD2 0.0133 0.3671 0.3671
Brugia malayi Phosphoglycerate kinase 0.007 0.1759 0.2271
Schistosoma mansoni DNA helicase recq1 0.0021 0.0289 0.0289
Loa Loa (eye worm) MH2 domain-containing protein 0.0133 0.3671 0.3671
Mycobacterium leprae Probable phosphoglycerate kinase Pgk 0.019 0.5377 1
Trichomonas vaginalis chromobox protein, putative 0.0078 0.2001 0.3669
Brugia malayi SET domain containing protein 0.0014 0.008 0.0104
Giardia lamblia Phosphoglycerate kinase 0.019 0.5377 1
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0026 0.0446 0.0754
Echinococcus granulosus thioredoxin glutathione reductase 0.0053 0.1249 0.1249
Brugia malayi hypothetical protein 0.004 0.0869 0.1122
Plasmodium vivax hypothetical protein, conserved 0.0013 0.0044 0.00000000061472
Entamoeba histolytica chromodomain-helicase-DNA-binding protein, putative 0.0013 0.0044 0.00000000061472
Loa Loa (eye worm) helicase 0.0013 0.0044 0.0044

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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