TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 347.432 | Formula: C17H21N3O3S
H donors: 2 H acceptors: 3 LogP: 2.29 Rotable bonds: 6
Rule of 5 violations (Lipinski): 1
SMILES: CCN(c1ccc(c(c1)O)C=Nc1ccc(cc1)S(=O)(=O)N)CC
InChi: 1S/C17H21N3O3S/c1-3-20(4-2)15-8-5-13(17(21)11-15)12-19-14-6-9-16(10-7-14)24(18,22)23/h5-12,21H,3-4H2,1-2H3,(H2,18,22,23)/b19-12+
InChiKey: FIPKRYYNWIBJEI-XDHOZWIPSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus multilocularis	GPCR, family 3, C terminal	0.0035	0.0408	0.0408
Schistosoma mansoni	GTP-binding protein (q) alpha-11 subunit gna11	0.0002	0.001	0.0013
Loa Loa (eye worm)	hypothetical protein	0.002	0.0231	0.0277
Echinococcus granulosus	glutamate receptor 2	0.002	0.0231	0.0724
Mycobacterium tuberculosis	Probable D-amino acid oxidase Aao	0.0624	0.7619	1
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0046	0.0551	0.0551
Brugia malayi	Cytochrome P450 family protein	0.0026	0.0309	0.1196
Echinococcus multilocularis	glutamate receptor 2	0.002	0.0231	0.0231
Echinococcus granulosus	receptor type guanylyl cyclase	0.002	0.0231	0.0724
Giardia lamblia	Glycerol-3-phosphate dehydrogenase	0.0057	0.068	1
Mycobacterium leprae	PROBABLE D-AMINO ACID OXIDASE AAO	0.0681	0.8313	1
Brugia malayi	dimethylglycine dehydrogenase, mitochondrial precursor, putative	0.0057	0.068	0.263
Brugia malayi	guanine nucleotide-binding protein alpha-3 subunit, putative	0.0002	0.001	0.004
Brugia malayi	sterile alpha and TIR motif containing protein 1 isoform a	0.0007	0.0068	0.0262
Echinococcus multilocularis	nmda type glutamate receptor	0.002	0.0231	0.0231
Echinococcus multilocularis	guanine nucleotide binding protein subunit	0.0002	0.001	0.001
Brugia malayi	RE18450p	0.0057	0.068	0.263
Schistosoma mansoni	GTP-binding protein (I) alpha-2 subunit gnai2	0.0002	0.001	0.0013
Schistosoma mansoni	GTP-binding protein (I) alpha-2 subunit gnai2	0.0002	0.001	0.0013
Brugia malayi	Receptor family ligand binding region containing protein	0.0055	0.0653	0.2524
Brugia malayi	Guanylyl cyclase protein 23	0.002	0.0231	0.0892
Brugia malayi	Liprin-alpha 2	0.0007	0.0068	0.0262
Brugia malayi	Guanine nucleotide-binding protein alpha-3 subunit, putative	0.0002	0.001	0.004
Brugia malayi	metabotropic GABA-B receptor subtype 2	0.002	0.0231	0.0892
Toxoplasma gondii	poly(ADP-ribose) polymerase catalytic domain-containing protein	0.0011	0.0118	0.0817
Trypanosoma cruzi	FAD dependent oxidoreductase, putative	0.0057	0.068	1
Plasmodium vivax	FAD-dependent glycerol-3-phosphate dehydrogenase, putative	0.0057	0.068	1
Trichomonas vaginalis	conserved hypothetical protein	0.0011	0.0118	1
Schistosoma mansoni	hypothetical protein	0.0007	0.0068	0.0081
Brugia malayi	G-protein alpha subunit	0.0002	0.001	0.004
Schistosoma mansoni	fad oxidoreductase	0.0057	0.068	0.0818
Echinococcus granulosus	glutamate receptor ionotrophic AMPA 3	0.002	0.0231	0.0724
Schistosoma mansoni	GTP-binding protein alpha subunit	0.0002	0.001	0.0013
Onchocerca volvulus	Atrial natriuretic peptide receptor 3 homolog	0.002	0.0231	0.2742
Entamoeba histolytica	hypothetical protein	0.0011	0.0118	0.1603
Schistosoma mansoni	fad oxidoreductase	0.0057	0.068	0.0818
Onchocerca volvulus		0.002	0.0231	0.2742
Loa Loa (eye worm)	hypothetical protein	0.0057	0.068	0.0818
Schistosoma mansoni	GTP-binding protein (q) alpha-11 subunit gna11	0.0002	0.001	0.0013
Loa Loa (eye worm)	poly(ADP-ribose) polymerase	0.0011	0.0118	0.0142
Loa Loa (eye worm)	hypothetical protein	0.002	0.0231	0.0277
Onchocerca volvulus		0.0007	0.0068	0.0713
Brugia malayi	metabotropic GABA-B receptor subtype 2	0.0035	0.0408	0.1578
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0046	0.0551	0.1729
Entamoeba histolytica	hypothetical protein	0.002	0.0231	0.3287
Schistosoma mansoni	tankyrase	0.0075	0.0909	0.1093
Mycobacterium ulcerans	glycerol-3-phosphate dehydrogenase	0.0057	0.068	0.0736
Trichomonas vaginalis	conserved hypothetical protein	0.0007	0.0068	0.575
Loa Loa (eye worm)	metabotropic GABA-B receptor subtype 2	0.0055	0.0653	0.0785
Schistosoma mansoni	cytochrome P450	0.0007	0.0074	0.0089
Brugia malayi	pyruvate dehydrogenase phosphatase regulatory subunit precursor	0.0057	0.068	0.263
Trypanosoma brucei	electron transfer flavoprotein-ubiquinone oxidoreductase, putative	0.0057	0.068	1
Onchocerca volvulus	Tankyrase homolog	0.0068	0.0813	1
Echinococcus granulosus	glutamate receptor 2	0.002	0.0231	0.0724
Echinococcus multilocularis	liprin beta 1	0.0007	0.0068	0.0068
Loa Loa (eye worm)	metabotropic glutamate receptor 8	0.002	0.0231	0.0277
Echinococcus multilocularis	metabotropic glutamate receptor 2	0.0178	0.2164	0.2164
Schistosoma mansoni	poly [ADP-ribose] polymerase	0.0011	0.0118	0.0142
Trypanosoma cruzi	glycerol-3-phosphate dehydrogenase (FAD-dependent), putative	0.0057	0.068	1
Loa Loa (eye worm)	hypothetical protein	0.0002	0.001	0.0012
Schistosoma mansoni	GTP-binding protein alpha subunit gna	0.0002	0.001	0.0013
Schistosoma mansoni	metabotropic glutamate receptor	0.0178	0.2164	0.2603
Echinococcus multilocularis	receptor type guanylyl cyclase	0.002	0.0231	0.0231
Schistosoma mansoni	hypothetical protein	0.0007	0.0068	0.0081
Mycobacterium tuberculosis	Possible thiamine biosynthesis oxidoreductase ThiO	0.0057	0.068	0.0804
Trypanosoma cruzi	L-2-hydroxyglutarate dehydrogenase, mitochondrial, putative	0.0057	0.068	1
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0118	0.0142
Echinococcus multilocularis	guanine nucleotide binding protein subunit	0.0002	0.001	0.001
Trichomonas vaginalis	ankyrin, putative	0.0001	0	0.0011
Schistosoma mansoni	lar interacting protein (lip)-related protein	0.0007	0.0068	0.0081
Echinococcus multilocularis	glycerol 3 phosphate dehydrogenase	0.0057	0.068	0.068
Onchocerca volvulus	Dimethylglycine dehydrogenase, mitochondrial homolog	0.0057	0.068	0.8342
Leishmania major	extracellular receptor, putative	0.002	0.0231	0.2589
Trypanosoma cruzi	extracellular receptor, putative	0.002	0.0231	0.2589
Schistosoma mansoni	ATP:guanidino kinase (Smc74)	0.0057	0.068	0.0818
Loa Loa (eye worm)	hypothetical protein	0.0007	0.0068	0.0081
Trichomonas vaginalis	GTP-binding protein (q) alpha-11 subunit, gna11, putative	0.0002	0.001	0.0887
Schistosoma mansoni	GTP-binding protein (I) alpha subunit gnai	0.0002	0.001	0.0013
Echinococcus multilocularis	expressed protein	0.0002	0.001	0.001
Echinococcus multilocularis		0.0007	0.0074	0.0073
Brugia malayi	cytochrome P450	0.0007	0.0074	0.0285
Entamoeba histolytica	hypothetical protein	0.0011	0.0118	0.1603
Brugia malayi	coiled-coil like protein 1	0.0007	0.0068	0.0262
Loa Loa (eye worm)	hypothetical protein	0.0007	0.0068	0.0081
Loa Loa (eye worm)	tnks protein	0.0069	0.0827	0.0995
Brugia malayi	guanine nucleotide-binding protein G-o protein alpha subunit	0.0002	0.001	0.004
Echinococcus granulosus	nmda type glutamate receptor	0.002	0.0231	0.0724
Onchocerca volvulus		0.002	0.0231	0.2742
Echinococcus granulosus	guanine nucleotide binding protein subunit	0.0002	0.001	0.0033
Entamoeba histolytica	hypothetical protein	0.0011	0.0118	0.1603
Loa Loa (eye worm)	glutamate receptor	0.0213	0.2586	0.3111
Trichomonas vaginalis	ankyrin 2,3/unc44, putative	0.0001	0	0.0011
Echinococcus multilocularis	guanine nucleotide binding protein (G protein)	0.0002	0.001	0.001
Brugia malayi	hypothetical protein	0.0002	0.001	0.004
Toxoplasma gondii	hypothetical protein	0.0057	0.068	1
Loa Loa (eye worm)	hypothetical protein	0.0007	0.0068	0.0081
Echinococcus granulosus	stromal interaction molecule 1	0.0007	0.0068	0.0213
Trichomonas vaginalis	conserved hypothetical protein	0.0011	0.0118	1
Plasmodium falciparum	FAD-dependent glycerol-3-phosphate dehydrogenase, putative	0.0057	0.068	1
Brugia malayi	WGR domain containing protein	0.0011	0.0118	0.0455
Echinococcus granulosus	Sterile alpha motif SAM	0.0007	0.0068	0.0213
Trichomonas vaginalis	conserved hypothetical protein	0.0011	0.0118	1
Brugia malayi	hypothetical protein	0.002	0.0231	0.0892
Echinococcus granulosus	tyrosine kinase	0.002	0.0231	0.0724
Loa Loa (eye worm)	hypothetical protein	0.002	0.0231	0.0277
Schistosoma mansoni	lip-related protein (liprin) alpha	0.0007	0.0068	0.0081
Schistosoma mansoni	GTP-binding protein alpha subunit	0.0002	0.001	0.0013
Trichomonas vaginalis	GTP-binding protein (z) alpha subunit, gnaz, putative	0.0002	0.001	0.0887
Brugia malayi	Metabotropic glutamate receptor precursor.	0.0213	0.2586	1
Loa Loa (eye worm)	toll and interleukin 1 receptor domain-containing protein isoform f	0.0007	0.0068	0.0081
Mycobacterium ulcerans	D-amino acid oxidase Aao	0.0681	0.8313	1
Echinococcus granulosus	poly adp ribose polymerase 2	0.0011	0.0118	0.037
Brugia malayi	GTP-binding regulatory protein alpha chain - starfish, putative	0.0002	0.001	0.004
Mycobacterium ulcerans	D-amino acid oxidase Aao	0.0057	0.068	0.0736
Schistosoma mansoni	glycerol-3-phosphate dehydrogenase	0.0057	0.068	0.0818
Echinococcus multilocularis	Glutamate receptor, ionotropic kainate 2	0.002	0.0231	0.0231
Echinococcus multilocularis	Glutamate receptor, ionotropic kainate 2	0.002	0.0231	0.0231
Loa Loa (eye worm)	glutamate receptor	0.0084	0.1009	0.1214
Chlamydia trachomatis	D-amino acid dehydrogenase	0.0057	0.068	0.5
Loa Loa (eye worm)	hypothetical protein	0.0262	0.3187	0.3833
Trichomonas vaginalis	conserved hypothetical protein	0.0011	0.0118	1
Brugia malayi	Neurabin protein 1	0.0007	0.0068	0.0262
Trypanosoma cruzi	glycerol-3-phosphate dehydrogenase (FAD-dependent), putative	0.0057	0.068	1
Echinococcus granulosus	Glutamate receptor ionotropic kainate 2	0.002	0.0231	0.0724
Echinococcus multilocularis	SAM domain containing protein	0.0007	0.0068	0.0068
Trypanosoma cruzi	glycerol-3-phosphate dehydrogenase, putative	0.0057	0.068	1
Echinococcus multilocularis	tyrosine kinase	0.002	0.0231	0.0231
Trichomonas vaginalis	conserved hypothetical protein	0.0011	0.0118	1
Brugia malayi	WGR domain containing protein	0.0011	0.0118	0.0455
Echinococcus multilocularis	stromal interaction molecule 1	0.0007	0.0068	0.0068
Entamoeba histolytica	zinc finger protein, putative	0.0011	0.0118	0.1603
Schistosoma mansoni	glutamate receptor NMDA	0.002	0.0231	0.0277
Echinococcus granulosus	gtp binding protein I alpha 1subunit	0.0002	0.001	0.0033
Trypanosoma cruzi	Present in the outer mitochondrial membrane proteome 20	0.0057	0.068	1
Schistosoma mansoni	GTP-binding protein alpha subunit gna	0.0002	0.001	0.0013
Brugia malayi	metabotropic glutamate receptor subtype 5a (mGluR5a), putative	0.0193	0.2342	0.9055
Schistosoma mansoni	hypothetical protein	0.0007	0.0068	0.0081
Schistosoma mansoni	trimeric G-protein alpha o subunit	0.0002	0.001	0.0013
Brugia malayi	Receptor family ligand binding region containing protein	0.002	0.0231	0.0892
Echinococcus granulosus	sterile alpha and tir motif containing protein	0.0007	0.0068	0.0213
Mycobacterium leprae	Possible thiamine biosynthesis oxidoreductase ThiO	0.0057	0.068	0.0736
Toxoplasma gondii	cytochrome p450 superfamily protein	0.0007	0.0074	0.0096
Mycobacterium leprae	Probable cholesterol oxidase precursor ChoD (cholesterol-O2 oxidoreductase)	0.0057	0.068	0.0736
Echinococcus multilocularis	FAD dependent oxidoreductase domain containing protein	0.0057	0.068	0.068
Loa Loa (eye worm)	hypothetical protein	0.0007	0.0068	0.0081
Schistosoma mansoni	protein kinase	0.002	0.0231	0.0277
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0046	0.0551	0.0663
Schistosoma mansoni	sarm1	0.0007	0.0068	0.0081
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0046	0.0551	0.0551
Schistosoma mansoni	NAD dehydrogenase	0.0057	0.068	0.0818
Loa Loa (eye worm)	hypothetical protein	0.0002	0.001	0.0012
Echinococcus multilocularis	Glutamate receptor, ionotropic kainate 2	0.002	0.0231	0.0231
Echinococcus multilocularis	poly (adp ribose) polymerase 2	0.0011	0.0118	0.0118
Loa Loa (eye worm)	cytochrome P450 family protein	0.0007	0.0074	0.0088
Echinococcus granulosus	FAD dependent oxidoreductase domain containing protein	0.0057	0.068	0.2135
Schistosoma mansoni	tyrosine kinase	0.002	0.0231	0.0277
Entamoeba histolytica	hypothetical protein	0.0011	0.0118	0.1603
Entamoeba histolytica	poly(ADP-ribose) polymerase, putative	0.0011	0.0118	0.1603
Brugia malayi	Cytochrome P450 family protein	0.0007	0.0074	0.0285
Loa Loa (eye worm)	RGC/RGC protein kinase	0.002	0.0231	0.0277
Echinococcus multilocularis	liprin alpha 2	0.0007	0.0068	0.0068
Echinococcus multilocularis	gtp binding protein (I) alpha 1subunit	0.0002	0.001	0.001
Trichomonas vaginalis	conserved hypothetical protein	0.0011	0.0118	1
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0046	0.0551	0.0663
Schistosoma mansoni	GTP-binding protein (I) alpha-2 subunit gnai2	0.0002	0.001	0.0013
Mycobacterium ulcerans	glycerol-3-phosphate dehydrogenase GlpD2	0.0057	0.068	0.0736
Loa Loa (eye worm)	guanine nucleotide-binding protein alpha-6 subunit	0.0002	0.001	0.0012
Trichomonas vaginalis	conserved hypothetical protein	0.0011	0.0118	1
Echinococcus granulosus	Glutamate receptor ionotropic kainate 2	0.002	0.0231	0.0724
Loa Loa (eye worm)	hypothetical protein	0.0057	0.068	0.0818
Trichomonas vaginalis	GTP-binding protein alpha subunit, gna, putative	0.0002	0.001	0.0887
Loa Loa (eye worm)	guanine nucleotide-binding protein alpha-12 subunit	0.0002	0.001	0.0012
Echinococcus granulosus	glycerol 3 phosphate dehydrogenase	0.0057	0.068	0.2135
Loa Loa (eye worm)	hypothetical protein	0.0007	0.0068	0.0081
Leishmania major	hypothetical protein, conserved	0.0057	0.068	1
Loa Loa (eye worm)	RGC/RGC protein kinase	0.002	0.0231	0.0277
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0046	0.0551	0.0663
Loa Loa (eye worm)	CYP4Cod1	0.0007	0.0074	0.0088
Echinococcus multilocularis	poly (ADP ribose) polymerase 1	0.0011	0.0118	0.0118
Loa Loa (eye worm)	hypothetical protein	0.0002	0.001	0.0012
Mycobacterium ulcerans	thiamine biosynthesis oxidoreductase ThiO	0.0057	0.068	0.0736
Echinococcus multilocularis	guanine nucleotide binding protein (G protein)	0.0002	0.001	0.001
Echinococcus granulosus	expressed protein	0.0002	0.001	0.0033
Echinococcus granulosus	SAM domain containing protein	0.0007	0.0068	0.0213
Loa Loa (eye worm)	RGC/RGC protein kinase	0.002	0.0231	0.0277
Trypanosoma brucei	L-2-hydroxyglutarate dehydrogenase, mitochondrial, putative	0.0057	0.068	1
Trypanosoma brucei	glycerol-3-phosphate dehydrogenase (FAD-dependent), mitochondrial	0.0057	0.068	1
Loa Loa (eye worm)	hypothetical protein	0.0681	0.8313	1
Entamoeba histolytica	anaerobic glycerol-3-phosphate dehydrogenase subunit A, putative	0.0057	0.068	1
Trichomonas vaginalis	GTP-binding protein alpha subunit, gna, putative	0.0002	0.001	0.0887
Brugia malayi	hypothetical protein	0.0007	0.0068	0.0262
Trypanosoma brucei	poly(adp-ribose) polymerase	0.0011	0.0118	0.0729
Brugia malayi	Guanine nucleotide-binding protein alpha-12 subunit, putative	0.0002	0.001	0.004
Brugia malayi	Guanine nucleotide-binding protein alpha-3 subunit, putative	0.0002	0.001	0.004
Trichomonas vaginalis	conserved hypothetical protein	0.0007	0.0068	0.575
Echinococcus multilocularis	tankyrase	0.0075	0.0908	0.0908
Trichomonas vaginalis	c2h2 zinc finger protein, putative	0.0007	0.0068	0.575
Loa Loa (eye worm)	glycerol-3-phosphate dehydrogenase	0.0057	0.068	0.0818
Onchocerca volvulus		0.0007	0.0068	0.0713
Trichomonas vaginalis	G protein (olf) alpha subunit, gnal, putative	0.0002	0.001	0.0887
Echinococcus granulosus	liprin alpha 2	0.0007	0.0068	0.0213
Schistosoma mansoni	metabotropic glutamate receptor	0.0104	0.1253	0.1508
Schistosoma mansoni	tyrosine kinase	0.002	0.0231	0.0277
Trichomonas vaginalis	GTP-binding protein alpha subunit, gna, putative	0.0002	0.001	0.0887
Schistosoma mansoni	hypothetical protein	0.0035	0.0408	0.0491
Echinococcus granulosus	poly ADP ribose polymerase 1	0.0011	0.0118	0.037
Loa Loa (eye worm)	receptor family ligand binding region containing protein	0.0055	0.0653	0.0785
Trichomonas vaginalis	GTP-binding protein alpha subunit, gna, putative	0.0002	0.001	0.0887
Echinococcus multilocularis	metabotropic glutamate receptor 5	0.0262	0.3187	0.3187
Trypanosoma cruzi	poly(ADP-ribose) polymerase, putative	0.0011	0.0118	0.0729
Brugia malayi	hypothetical protein	0.0007	0.0068	0.0262
Trichomonas vaginalis	conserved hypothetical protein	0.0007	0.0068	0.575
Onchocerca volvulus	Metabotropic glutamate receptor homolog	0.0035	0.0408	0.4953
Brugia malayi	Cytochrome P450 family protein	0.0007	0.0074	0.0285
Trichomonas vaginalis	GTP-binding protein (O) alpha subunit, gnao, putative	0.0002	0.001	0.0887
Echinococcus multilocularis	glutamate receptor, ionotrophic, AMPA 3	0.002	0.0231	0.0231
Loa Loa (eye worm)	hypothetical protein	0.0057	0.0683	0.0822
Brugia malayi	Cytochrome P450 family protein	0.0007	0.0074	0.0285
Echinococcus granulosus	cytochrome P450 2K1	0.0007	0.0074	0.0231
Leishmania major	hypothetical protein, conserved	0.0057	0.068	1
Entamoeba histolytica	NAD(FAD)-dependent dehydrogenase, putative	0.0057	0.068	1
Loa Loa (eye worm)	heterotrimeric G protein alpha subunit	0.0002	0.001	0.0012
Echinococcus multilocularis	poly (ADP ribose) polymerase	0.0011	0.0118	0.0118
Schistosoma mansoni	GTP-binding protein (I) alpha-1subunit gnai1	0.0002	0.001	0.0013
Schistosoma mansoni	hypothetical protein	0.0007	0.0068	0.0081
Trichomonas vaginalis	conserved hypothetical protein	0.0011	0.0118	1
Trypanosoma brucei	glycerol-3-phosphate dehydrogenase (FAD-dependent), putative	0.0057	0.068	1
Echinococcus granulosus	Glutamate receptor ionotropic kainate 2	0.002	0.0231	0.0724
Echinococcus granulosus	guanine nucleotide binding protein G protein	0.0002	0.001	0.0033
Onchocerca volvulus	Poor gastrulation protein homolog	0.0035	0.0408	0.4953
Toxoplasma gondii	FAD-dependent glycerol-3-phosphate dehydrogenase	0.0057	0.068	1
Schistosoma mansoni	hypothetical protein	0.0007	0.0074	0.0089
Trypanosoma cruzi	poly(ADP-ribose) polymerase, putative	0.0011	0.0118	0.0729
Loa Loa (eye worm)	hypothetical protein	0.0002	0.001	0.0012
Loa Loa (eye worm)	hypothetical protein	0.0002	0.001	0.0012
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0046	0.0551	0.2131
Echinococcus granulosus	tankyrase	0.0075	0.0908	0.2848
Echinococcus granulosus	metabotropic glutamate receptor 5	0.0262	0.3187	1
Schistosoma mansoni	poly [ADP-ribose] polymerase	0.0011	0.0118	0.0142
Loa Loa (eye worm)	cytochrome P450 family protein	0.0026	0.0309	0.0372
Onchocerca volvulus	Pyruvate dehydrogenase phosphatase regulatory subunit, mitochondrial homolog	0.0057	0.068	0.8342
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0408	0.0491
Loa Loa (eye worm)	hypothetical protein	0.0057	0.068	0.0818
Echinococcus granulosus	metabotropic glutamate receptor 2	0.0178	0.2164	0.6791
Loa Loa (eye worm)	cytochrome P450	0.0007	0.0074	0.0088
Schistosoma mansoni	GTP-binding protein (I) alpha-1subunit gnai1	0.0002	0.001	0.0013
Trichomonas vaginalis	conserved hypothetical protein	0.0007	0.0068	0.575
Brugia malayi	Tnks protein	0.0074	0.0896	0.3466
Schistosoma mansoni	d-amino acid oxidase	0.0681	0.8313	1
Trypanosoma cruzi	L-2-hydroxyglutarate dehydrogenase, mitochondrial, putative	0.0057	0.068	1
Trichomonas vaginalis	ankyrin repeat-containing protein, putative	0.0001	0	0.0011
Echinococcus granulosus	liprin beta 1	0.0007	0.0068	0.0213
Echinococcus granulosus	GPCR family 3 C terminal	0.0035	0.0408	0.1281
Loa Loa (eye worm)	hypothetical protein	0.002	0.0231	0.0277
Loa Loa (eye worm)	hypothetical protein	0.002	0.0231	0.0277
Echinococcus granulosus	atrial natriuretic peptide receptor	0.002	0.0231	0.0724
Echinococcus multilocularis	sterile alpha and tir motif containing protein	0.0007	0.0068	0.0068
Echinococcus granulosus	guanine nucleotide binding protein G protein	0.0002	0.001	0.0033
Brugia malayi	cDNA sequence BC016226	0.0057	0.068	0.263
Brugia malayi	guanine nucleotide-binding protein alpha-7 subunit, putative	0.0002	0.001	0.004
Brugia malayi	metabotropic glutamate receptor type 2	0.0104	0.1253	0.4847
Loa Loa (eye worm)	hypothetical protein	0.0055	0.0653	0.0785
Echinococcus granulosus	guanine nucleotide binding protein subunit	0.0002	0.001	0.0033
Trypanosoma brucei	FAD dependent oxidoreductase, putative	0.0057	0.068	1
Loa Loa (eye worm)	G protein alpha subunit 3	0.0002	0.001	0.0012
Echinococcus multilocularis	glutamate receptor 2	0.002	0.0231	0.0231
Loa Loa (eye worm)	cytochrome P450 family protein	0.0007	0.0074	0.0088
Brugia malayi	guanine nucleotide-binding protein G(o), alpha subunit, putative	0.0002	0.001	0.004
Loa Loa (eye worm)	hypothetical protein	0.002	0.0231	0.0277
Loa Loa (eye worm)	hypothetical protein	0.002	0.0231	0.0277
Onchocerca volvulus	Putative fad oxidoreductase	0.0057	0.068	0.8342
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0046	0.0551	0.1729
Echinococcus multilocularis	atrial natriuretic peptide receptor	0.002	0.0231	0.0231
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0046	0.0551	0.0663
Schistosoma mansoni	metabotropic glutamate receptor 2 3 (mglur group 2)	0.0242	0.2943	0.3539
Trichomonas vaginalis	conserved hypothetical protein	0.0011	0.0118	1
Loa Loa (eye worm)	GTP-binding regulatory protein alpha chain	0.0002	0.001	0.0012
Leishmania major	glycerol-3-phosphate dehydrogenase-like protein	0.0057	0.068	1
Brugia malayi	Guanine nucleotide-binding protein alpha-6 subunit, putative	0.0002	0.001	0.004

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

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Bibliographic References

No literature references available for this target.

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Detailed information for compound 808032