Detailed information for compound 810309

Basic information

Technical information
  • TDR Targets ID: 810309
  • Name: 5-[[5-(4-fluorophenyl)furan-2-yl]methylidene] -3-methyl-2-sulfanylidene-1,3-thiazolidin-4-o ne
  • MW: 319.374 | Formula: C15H10FNO2S2
  • H donors: 0 H acceptors: 1 LogP: 3.84 Rotable bonds: 2
    Rule of 5 violations (Lipinski): 1
  • SMILES: Fc1ccc(cc1)c1ccc(o1)C=C1SC(=S)N(C1=O)C
  • InChi: 1S/C15H10FNO2S2/c1-17-14(18)13(21-15(17)20)8-11-6-7-12(19-11)9-2-4-10(16)5-3-9/h2-8H,1H3/b13-8-
  • InChiKey: JVXYFDJBHTVHKL-JYRVWZFOSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • (5Z)-5-[[5-(4-fluorophenyl)furan-2-yl]methylidene]-3-methyl-2-sulfanylidene-1,3-thiazolidin-4-one
  • 5-[[5-(4-fluorophenyl)-2-furyl]methylene]-3-methyl-2-thioxo-thiazolidin-4-one
  • (5Z)-5-[[5-(4-fluorophenyl)-2-furyl]methylene]-3-methyl-2-thioxo-thiazolidin-4-one
  • 5-[[5-(4-fluorophenyl)-2-furyl]methylene]-3-methyl-2-thioxo-4-thiazolidinone
  • (5Z)-5-[[5-(4-fluorophenyl)-2-furyl]methylene]-3-methyl-2-thioxo-4-thiazolidinone
  • BIM-0017244.P001
  • ZINC01193125
  • CBMicro_017030

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trichomonas vaginalis malate dehydrogenase, putative 0.0125 0.2988 0.3696
Trypanosoma cruzi glycosomal malate dehydrogenase, putative 0.0125 0.2988 0.3323
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0053 0.041 0.0333
Toxoplasma gondii lactate dehydrogenase LDH1 0.0322 1 1
Loa Loa (eye worm) CYP4Cod1 0.0046 0.0175 0.0096
Loa Loa (eye worm) MBCTL1 0.0053 0.041 0.0333
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0139 0.348 0.3871
Echinococcus multilocularis lactate dehydrogenase a 0.0322 1 1
Brugia malayi mbt repeat family protein 0.0046 0.0181 0.0102
Echinococcus granulosus histone acetyltransferase MYST2 0.0053 0.041 0.0333
Schistosoma mansoni survival motor neuron protein 0.0048 0.0231 0.0152
Schistosoma mansoni sex comb on midleg homolog 0.0046 0.0181 0.0102
Leishmania major cytochrome p450-like protein 0.0046 0.0175 0.0096
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0053 0.041 0.0333
Echinococcus multilocularis cytosolic malate dehydrogenase 0.0125 0.2988 0.2931
Schistosoma mansoni malate dehydrogenase 0.0125 0.2988 0.2931
Trichomonas vaginalis malate and lactate dehydrogenase, putative 0.0125 0.2988 0.3696
Trichomonas vaginalis malate dehydrogenase, putative 0.0125 0.2988 0.3696
Trypanosoma brucei glycosomal malate dehydrogenase 0.0125 0.2988 0.3323
Brugia malayi Pre-SET motif family protein 0.0206 0.5873 0.584
Trichomonas vaginalis malate dehydrogenase, putative 0.0125 0.2988 0.3696
Echinococcus multilocularis lactate dehydrogenase protein 0.0322 1 1
Schistosoma mansoni sex comb on midleg homolog 0.0046 0.0181 0.0102
Schistosoma mansoni malate dehydrogenase 0.0125 0.2988 0.2931
Toxoplasma gondii malate dehydrogenase MDH 0.0322 1 1
Brugia malayi Cytochrome P450 family protein 0.0046 0.0175 0.0096
Leishmania major mitochondrial DNA polymerase beta 0.0293 0.8991 0.8983
Trichomonas vaginalis malate and lactate dehydrogenase, putative 0.0125 0.2988 0.3696
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0046 0.0181 0.0102
Trichomonas vaginalis malate dehydrogenase, putative 0.0125 0.2988 0.3696
Echinococcus granulosus L lactate dehydrogenase 0.0197 0.5541 0.5505
Trichomonas vaginalis malate dehydrogenase, putative 0.0125 0.2988 0.3696
Loa Loa (eye worm) cytochrome P450 family protein 0.0067 0.0917 0.0844
Echinococcus multilocularis polycomb protein SCMH1 0.0046 0.0181 0.0102
Trypanosoma cruzi glycosomal malate dehydrogenase, putative 0.0125 0.2988 0.3323
Schistosoma mansoni malate dehydrogenase 0.0322 1 1
Trypanosoma cruzi cytosolic malate dehydrogenase, putative 0.0125 0.2988 0.3323
Schistosoma mansoni L-lactate dehydrogenase 0.0125 0.2988 0.2931
Brugia malayi hypothetical protein 0.0147 0.3764 0.3713
Loa Loa (eye worm) hypothetical protein 0.0322 1 1
Leishmania major malate dehydrogenase, putative 0.0125 0.2988 0.2931
Trichomonas vaginalis malate dehydrogenase, putative 0.0125 0.2988 0.3696
Loa Loa (eye worm) cytochrome P450 family protein 0.0046 0.0175 0.0096
Trypanosoma cruzi cytochrome P450, putative 0.0046 0.0175 0.0195
Onchocerca volvulus 0.0048 0.0231 0.0074
Trypanosoma cruzi malate dehydrogenase, putative 0.0125 0.2988 0.3323
Brugia malayi Probable malate dehydrogenase, mitochondrial precursor 0.0125 0.2988 0.2931
Giardia lamblia Malate dehydrogenase 0.0125 0.2988 0.5
Loa Loa (eye worm) hypothetical protein 0.0147 0.3764 0.3713
Echinococcus multilocularis survival motor neuron protein 1 0.0234 0.6874 0.6849
Echinococcus granulosus L lactate dehydrogenase B chain 0.0322 1 1
Schistosoma mansoni malate dehydrogenase 0.0125 0.2988 0.2931
Echinococcus multilocularis malate dehydrogenase 0.0125 0.2988 0.2931
Loa Loa (eye worm) malate dehydrogenase 0.0125 0.2988 0.2931
Echinococcus granulosus cytosolic malate dehydrogenase 0.0125 0.2988 0.2931
Echinococcus granulosus malate dehydrogenase 0.0125 0.2988 0.2931
Loa Loa (eye worm) mbt repeat family protein 0.0046 0.0181 0.0102
Echinococcus multilocularis cytosolic malate dehydrogenase 0.0125 0.2988 0.2931
Onchocerca volvulus 0.0234 0.6888 1
Echinococcus granulosus survival motor neuron protein 1 0.0234 0.6874 0.6849
Echinococcus granulosus malate dehydrogenase 0.0125 0.2988 0.2931
Brugia malayi Malate dehydrogenase, cytoplasmic 0.0125 0.2988 0.2931
Trypanosoma brucei cytochrome P450, putative 0.0046 0.0175 0.0195
Leishmania major cytosolic malate dehydrogenase 0.0125 0.2988 0.2931
Plasmodium vivax malate dehydrogenase, putative 0.0322 1 1
Trichomonas vaginalis malate and lactate dehydrogenase, putative 0.0125 0.2988 0.3696
Echinococcus multilocularis L lactate dehydrogenase 0.0197 0.5541 0.5505
Entamoeba histolytica malate dehydrogenase, putative 0.0322 1 1
Trichomonas vaginalis malate dehydrogenase, putative 0.0125 0.2988 0.3696
Brugia malayi hypothetical protein 0.0234 0.6874 0.6849
Toxoplasma gondii lactate dehydrogenase LDH2 0.0322 1 1
Brugia malayi mbt repeat family protein 0.0046 0.0181 0.0102
Trichomonas vaginalis malate dehydrogenase, putative 0.0125 0.2988 0.3696
Brugia malayi Cytochrome P450 family protein 0.0067 0.0917 0.0844
Plasmodium falciparum malate dehydrogenase 0.0322 1 1
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.005 0.0322 0.0358
Echinococcus multilocularis histone acetyltransferase MYST2 0.0053 0.041 0.0333
Leishmania major malate dehydrogenase, putative 0.0322 1 1
Mycobacterium ulcerans malate dehydrogenase 0.0125 0.2988 0.7278
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0293 0.8991 1
Schistosoma mansoni myelin transcription factor 1 myt1 0.0053 0.041 0.0333
Leishmania major mitochondrial malate dehydrogenase 0.0125 0.2988 0.2931
Onchocerca volvulus 0.0147 0.3764 0.5341
Echinococcus granulosus lactate dehydrogenase protein 0.0322 1 1
Trypanosoma brucei DNA polymerase eta, putative 0.0043 0.008 0.0089
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0183 0.5041 0.5001
Loa Loa (eye worm) hypothetical protein 0.0234 0.6874 0.6849
Echinococcus multilocularis lactate dehydrogenase a 0.0322 1 1
Trichomonas vaginalis malate dehydrogenase, putative 0.0125 0.2988 0.3696
Trypanosoma cruzi cytochrome P450, putative 0.0046 0.0175 0.0195
Echinococcus granulosus lactate dehydrogenase a 0.0322 1 1
Echinococcus granulosus SAM and MBT domain containing protein 0.0046 0.0181 0.0102
Brugia malayi Cytochrome P450 family protein 0.0046 0.0175 0.0096
Loa Loa (eye worm) hypothetical protein 0.0046 0.0181 0.0102
Mycobacterium leprae PROBABLE MALATE DEHYDROGENASE MDH 0.0125 0.2988 0.5
Schistosoma mansoni L-lactate dehydrogenase 0.0322 1 1
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0139 0.348 0.3428
Plasmodium vivax lactate dehydrogenase 0.0322 1 1
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0048 0.0231 0.0152
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0206 0.5873 0.584
Loa Loa (eye worm) cytochrome P450 family protein 0.0046 0.0175 0.0096
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0293 0.8991 1
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0053 0.041 0.0333
Echinococcus multilocularis SAM and MBT domain containing protein 0.0046 0.0181 0.0102
Trypanosoma brucei cytosolic malate dehydrogenase 0.0125 0.2988 0.3323
Trichomonas vaginalis set domain proteins, putative 0.0234 0.6888 1
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0139 0.348 0.3871
Trypanosoma cruzi cytosolic malate dehydrogenase, putative 0.0125 0.2988 0.3323
Echinococcus multilocularis lactate dehydrogenase a 0.0322 1 1
Echinococcus granulosus lactate dehydrogenase a 0.0322 1 1
Leishmania major glycosomal malate dehydrogenase 0.0125 0.2988 0.2931
Trichomonas vaginalis malate and lactate dehydrogenase, putative 0.0125 0.2988 0.3696
Leishmania major malate dehydrogenase 0.0125 0.2988 0.2931
Trichomonas vaginalis malate dehydrogenase, putative 0.0125 0.2988 0.3696
Trypanosoma brucei malate dehydrogenase-related 0.0125 0.2988 0.3323
Trypanosoma brucei mitochondrial malate dehydrogenase 0.0125 0.2988 0.3323
Echinococcus granulosus polycomb protein SCMH1 0.0046 0.0181 0.0102
Mycobacterium tuberculosis Conserved hypothetical protein 0.0155 0.404 1
Trypanosoma cruzi DNA polymerase eta, putative 0.0043 0.008 0.0089
Trypanosoma cruzi malate dehydrogenase, putative 0.0125 0.2988 0.3323
Plasmodium falciparum L-lactate dehydrogenase 0.0322 1 1
Loa Loa (eye worm) hypothetical protein 0.0053 0.041 0.0333
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0183 0.5041 0.5001
Trypanosoma cruzi mitochondrial malate dehydrogenase, putative 0.0125 0.2988 0.3323
Schistosoma mansoni hypothetical protein 0.0048 0.0231 0.0152
Echinococcus multilocularis L lactate dehydrogenase B chain 0.0322 1 1
Schistosoma mansoni hypothetical protein 0.0282 0.8574 0.8563
Chlamydia trachomatis malate dehydrogenase 0.0125 0.2988 0.5
Mycobacterium ulcerans hypothetical protein 0.0155 0.404 1
Trichomonas vaginalis malate dehydrogenase, putative 0.0125 0.2988 0.3696
Trichomonas vaginalis malate dehydrogenase, putative 0.0125 0.2988 0.3696
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0293 0.8991 1
Echinococcus granulosus cytosolic malate dehydrogenase 0.0125 0.2988 0.2931
Loa Loa (eye worm) malate dehydrogenase 0.0125 0.2988 0.2931
Echinococcus multilocularis malate dehydrogenase 0.0125 0.2988 0.2931
Wolbachia endosymbiont of Brugia malayi malate dehydrogenase 0.0322 1 0.5

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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