Detailed information for compound 810971

Basic information

Technical information
  • TDR Targets ID: 810971
  • Name: 5-[(5-bromofuran-2-yl)methylidene]-2-sulfanyl idene-3-[3-(trifluoromethyl)phenyl]-1,3-thiaz olidin-4-one
  • MW: 434.251 | Formula: C15H7BrF3NO2S2
  • H donors: 0 H acceptors: 1 LogP: 5.55 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: S=C1SC(=Cc2ccc(o2)Br)C(=O)N1c1cccc(c1)C(F)(F)F
  • InChi: 1S/C15H7BrF3NO2S2/c16-12-5-4-10(22-12)7-11-13(21)20(14(23)24-11)9-3-1-2-8(6-9)15(17,18)19/h1-7H/b11-7-
  • InChiKey: QHNRZILIHSUWLA-XFFZJAGNSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • (5Z)-5-[(5-bromofuran-2-yl)methylidene]-2-sulfanylidene-3-[3-(trifluoromethyl)phenyl]-1,3-thiazolidin-4-one
  • 5-[(5-bromo-2-furyl)methylene]-2-thioxo-3-[3-(trifluoromethyl)phenyl]thiazolidin-4-one
  • (5Z)-5-[(5-bromo-2-furyl)methylene]-2-thioxo-3-[3-(trifluoromethyl)phenyl]thiazolidin-4-one
  • 5-[(5-bromo-2-furyl)methylene]-2-thioxo-3-[3-(trifluoromethyl)phenyl]-4-thiazolidinone
  • (5Z)-5-[(5-bromo-2-furyl)methylene]-2-thioxo-3-[3-(trifluoromethyl)phenyl]-4-thiazolidinone
  • ZINC01206400
  • CBMicro_009117
  • BIM-0009187.P001

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Mycobacterium leprae cell division protein FtsZ 0.0173 0 0.5
Trypanosoma brucei epsilon tubulin 0.0399 0.299 0.299
Trichomonas vaginalis tubulin alpha chain, putative 0.0929 1 1
Trypanosoma cruzi alpha tubulin, putative 0.0453 0.3696 0.3696
Echinococcus multilocularis tubulin alpha 3 chain 0.0453 0.3696 0.3696
Entamoeba histolytica tubulin alpha chain, putative 0.0453 0.3696 0.1006
Brugia malayi tubulin alpha-2 chain 0.0453 0.3696 0.3696
Leishmania major beta tubulin 0.0929 1 1
Trichomonas vaginalis tubulin beta chain, putative 0.0453 0.3696 0.3696
Leishmania major beta tubulin 0.0929 1 1
Brugia malayi alpha-tubulin 0.0453 0.3696 0.3696
Entamoeba histolytica tubulin family protein 0.0929 1 1
Schistosoma mansoni tubulin subunit alpha 0.0453 0.3696 0.3696
Giardia lamblia Alpha-tubulin 0.0453 0.3696 0.3696
Leishmania major beta tubulin 0.0929 1 1
Trypanosoma brucei alpha tubulin 0.0453 0.3696 0.3696
Leishmania major alpha tubulin 0.0453 0.3696 0.3696
Trichomonas vaginalis tubulin alpha chain, putative 0.0226 0.0696 0.0696
Trichomonas vaginalis tubulin alpha chain, putative 0.0226 0.0696 0.0696
Echinococcus multilocularis Tubulin alpha 1 chain 0.0453 0.3696 0.3696
Loa Loa (eye worm) tubulin gamma chain 0.0399 0.299 0.299
Echinococcus granulosus Tubulin alpha 1 chain 0.0453 0.3696 0.3696
Trypanosoma brucei alpha tubulin 0.0453 0.3696 0.3696
Leishmania major beta tubulin 0.0929 1 1
Trichomonas vaginalis tubulin epsilon chain, putative 0.0929 1 1
Mycobacterium tuberculosis Cell division protein FtsZ 0.0173 0 0.5
Loa Loa (eye worm) tubulin alpha 2 0.0279 0.1401 0.1401
Plasmodium falciparum alpha tubulin 1 0.0453 0.3696 0.3696
Entamoeba histolytica tubulin alpha-1 chain 0.0453 0.3696 0.1006
Plasmodium falciparum tubulin gamma chain 0.0399 0.299 0.299
Echinococcus granulosus tubulin beta 4A class IVa 0.0929 1 1
Schistosoma mansoni alpha tubulin 0.0453 0.3696 0.3696
Loa Loa (eye worm) BEN-1 protein 0.0929 1 1
Leishmania major alpha tubulin 0.0453 0.3696 0.3696
Echinococcus granulosus Tubulin alpha 1 chain 0.0453 0.3696 0.3696
Plasmodium vivax tubulin beta chain, putative 0.0929 1 1
Echinococcus granulosus alpha tubulin 0.0453 0.3696 0.3696
Echinococcus granulosus tubulin beta 1 chain 0.0929 1 1
Brugia malayi Tubulin gamma chain 0.0399 0.299 0.299
Trichomonas vaginalis tubulin gamma chain, putative 0.0399 0.299 0.299
Echinococcus multilocularis tubulin alpha chain 0.0453 0.3696 0.3696
Schistosoma mansoni tubulin subunit beta 0.0929 1 1
Echinococcus granulosus tubulin alpha chain 0.0453 0.3696 0.3696
Loa Loa (eye worm) tubulin beta-2A chain 0.0929 1 1
Trichomonas vaginalis tubulin, putative 0.0226 0.0696 0.0696
Loa Loa (eye worm) tubulin beta chain 0.0929 1 1
Echinococcus granulosus Tubulin beta 2C chain 0.0929 1 1
Giardia lamblia Beta tubulin 0.0929 1 1
Leishmania major gamma-tubulin 0.0399 0.299 0.299
Trichomonas vaginalis tubulin beta chain, putative 0.0226 0.0696 0.0696
Loa Loa (eye worm) alpha-tubulin 0.0453 0.3696 0.3696
Toxoplasma gondii beta-1 tubulin, putative 0.0929 1 1
Leishmania major beta tubulin 0.0929 1 1
Echinococcus granulosus tubulin subunit TubB 0.0453 0.3696 0.3696
Plasmodium vivax tubulin epsilon chain, putative 0.0399 0.299 0.299
Mycobacterium ulcerans cell division protein FtsZ 0.0173 0 0.5
Leishmania major beta tubulin 0.0929 1 1
Echinococcus multilocularis tubulin alpha 3 chain 0.0453 0.3696 0.3696
Plasmodium vivax tubulin gamma chain, putative 0.0399 0.299 0.299
Leishmania major alpha tubulin 0.0453 0.3696 0.3696
Trichomonas vaginalis tubulin, putative 0.0929 1 1
Brugia malayi beta-tubulin, identical 0.0929 1 1
Echinococcus multilocularis tubulin alpha chain 0.0453 0.3696 0.3696
Trypanosoma brucei epsilon tubulin 0.0399 0.299 0.299
Echinococcus multilocularis beta tubulin 0.0929 1 1
Plasmodium vivax tubulin alpha chain, putative 0.0453 0.3696 0.3696
Echinococcus granulosus peroxisome assembly protein 26 0.0453 0.3696 0.3696
Toxoplasma gondii beta-tubulin, putative 0.0929 1 1
Leishmania major alpha tubulin 0.0453 0.3696 0.3696
Leishmania major alpha tubulin 0.0453 0.3696 0.3696
Leishmania major alpha tubulin 0.0453 0.3696 0.3696
Echinococcus multilocularis tubulin alpha chain 0.0453 0.3696 0.3696
Echinococcus granulosus Tubulin alpha 1 chain 0.0453 0.3696 0.3696
Trichomonas vaginalis tubulin beta chain, putative 0.0453 0.3696 0.3696
Schistosoma mansoni tubulin subunit beta 0.0929 1 1
Loa Loa (eye worm) alpha-tubulin isotype 2 0.0279 0.1401 0.1401
Trichomonas vaginalis tubulin, putative 0.0226 0.0696 0.0696
Echinococcus multilocularis tubulin epsilon chain 0.0399 0.299 0.299
Giardia lamblia Alpha-tubulin 0.0453 0.3696 0.3696
Echinococcus granulosus tubulin gamma 1 chain 0.0399 0.299 0.299
Loa Loa (eye worm) hypothetical protein 0.0227 0.0705 0.0705
Echinococcus granulosus tubulin alpha chain 0.0453 0.3696 0.3696
Entamoeba histolytica tubulin family protein 0.0929 1 1
Schistosoma mansoni tubulin subunit gamma 0.0399 0.299 0.299
Toxoplasma gondii alpha tubulin TUBA1 0.0453 0.3696 0.3696
Trypanosoma brucei tubulin gamma chain 0.0399 0.299 0.299
Echinococcus multilocularis tubulin alpha 1C chain 0.0453 0.3696 0.3696
Trichomonas vaginalis tubulin gamma chain, putative 0.0929 1 1
Echinococcus granulosus tubulin alpha 3 chain 0.0453 0.3696 0.3696
Treponema pallidum cell division protein FtsZ 0.0173 0 0.5
Echinococcus granulosus tubulin alpha 1C chain 0.0453 0.3696 0.3696
Leishmania major beta tubulin 0.0929 1 1
Brugia malayi Tubulin beta chain 0.0226 0.0696 0.0696
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.0226 0.0696 0.0696
Echinococcus multilocularis beta tubulin 0.0929 1 1
Schistosoma mansoni alpha tubulin 0.0453 0.3696 0.3696
Loa Loa (eye worm) BEN-1 protein 0.0929 1 1
Giardia lamblia Gamma tubulin 0.0399 0.299 0.299
Echinococcus granulosus Tubulin beta 2C chain 0.0929 1 1
Leishmania major beta tubulin 0.0929 1 1
Toxoplasma gondii tubulin/FtsZ family, GTPase domain-containing protein 0.0399 0.299 0.299
Loa Loa (eye worm) hypothetical protein 0.0279 0.1401 0.1401
Echinococcus granulosus tubulin epsilon chain 0.0399 0.299 0.299
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.0227 0.0705 0.0705
Plasmodium falciparum tubulin epsilon chain, putative 0.0399 0.299 0.299
Trypanosoma cruzi tubulin gamma chain 0.0399 0.299 0.299
Trichomonas vaginalis tubulin beta chain, putative 0.0453 0.3696 0.3696
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.0279 0.1401 0.1401
Loa Loa (eye worm) tubulin alpha-3 chain 0.0227 0.0705 0.0705
Schistosoma mansoni tubulin subunit beta 0.0929 1 1
Echinococcus multilocularis tubulin subunit TubB 0.0453 0.3696 0.3696
Echinococcus granulosus Tubulin beta 2C chain 0.0929 1 1
Echinococcus multilocularis peroxisome assembly protein 26 0.0453 0.3696 0.3696
Echinococcus granulosus tubulin alpha 1C chain 0.0453 0.3696 0.3696
Trypanosoma brucei alpha tubulin, putative 0.0226 0.0696 0.0696
Echinococcus multilocularis tubulin alpha 1C chain 0.0453 0.3696 0.3696
Brugia malayi Tubulin alpha-2 chain 0.0453 0.3696 0.3696
Trichomonas vaginalis tubulin beta chain, putative 0.0453 0.3696 0.3696
Echinococcus multilocularis Tubulin beta 2C chain 0.0929 1 1
Brugia malayi Tubulin alpha chain 0.0453 0.3696 0.3696
Toxoplasma gondii alpha-tubulin I, putative 0.0453 0.3696 0.3696
Leishmania major alpha tubulin 0.0453 0.3696 0.3696
Trypanosoma brucei alpha tubulin 0.0453 0.3696 0.3696
Echinococcus granulosus beta tubulin 0.0929 1 1
Echinococcus multilocularis Tubulin alpha 1 chain 0.0453 0.3696 0.3696
Leishmania major alpha tubulin 0.0453 0.3696 0.3696
Leishmania major beta tubulin 0.0929 1 1
Leishmania major alpha tubulin 0.0453 0.3696 0.3696
Schistosoma mansoni tubulin subunit epsilon 0.0399 0.299 0.299
Trichomonas vaginalis tubulin beta chain, putative 0.0453 0.3696 0.3696
Echinococcus granulosus tubulin alpha 0.0399 0.299 0.299
Echinococcus multilocularis tubulin gamma 1 chain 0.0399 0.299 0.299
Echinococcus granulosus Tubulin beta 2C chain 0.0929 1 1
Plasmodium falciparum alpha tubulin 2 0.0453 0.3696 0.3696
Brugia malayi Tubulin alpha-2 chain 0.0453 0.3696 0.3696
Trypanosoma brucei alpha tubulin 0.0453 0.3696 0.3696
Trichomonas vaginalis tubulin gamma chain, putative 0.0399 0.299 0.299
Trypanosoma brucei beta tubulin 0.0929 1 1
Echinococcus multilocularis Tubulin beta 2C chain 0.0929 1 1
Schistosoma mansoni tubulin subunit beta 0.0929 1 1
Echinococcus granulosus tubulin alpha chain 0.0453 0.3696 0.3696
Trichomonas vaginalis tubulin beta chain, putative 0.0453 0.3696 0.3696
Leishmania major beta tubulin 0.0929 1 1
Schistosoma mansoni tubulin subunit alpha 0.0453 0.3696 0.3696
Trichomonas vaginalis tubulin epsilon chain, putative 0.0453 0.3696 0.3696
Echinococcus multilocularis Tubulin beta 2C chain 0.0929 1 1
Onchocerca volvulus 0.0226 0.0696 0.5
Loa Loa (eye worm) tubulin alpha 2 0.0279 0.1401 0.1401
Loa Loa (eye worm) hypothetical protein 0.0453 0.3696 0.3696
Echinococcus multilocularis tubulin alpha chain 0.0453 0.3696 0.3696
Trypanosoma brucei epsilon tubulin 0.0399 0.299 0.299
Trichomonas vaginalis tubulin epsilon chain, putative 0.0453 0.3696 0.3696
Loa Loa (eye worm) tubulin beta-1 chain 0.0929 1 1
Loa Loa (eye worm) beta-tubulin 0.0929 1 1
Loa Loa (eye worm) tubulin alpha-2 chain 0.0453 0.3696 0.3696
Loa Loa (eye worm) tubulin alpha chain 0.0453 0.3696 0.3696
Leishmania major beta tubulin 0.0929 1 1
Leishmania major epsilon tubulin, putative 0.0399 0.299 0.299
Plasmodium falciparum tubulin beta chain 0.0929 1 1
Loa Loa (eye worm) tubulin alpha chain 0.0453 0.3696 0.3696
Trypanosoma cruzi epsilon tubulin, putative 0.0399 0.299 0.299
Trypanosoma cruzi beta tubulin, putative 0.0929 1 1
Echinococcus granulosus tubulin alpha chain 0.0453 0.3696 0.3696
Giardia lamblia Beta tubulin 0.0929 1 1
Trichomonas vaginalis tubulin alpha chain, putative 0.0399 0.299 0.299
Trichomonas vaginalis tubulin epsilon chain, putative 0.0929 1 1
Leishmania major beta tubulin 0.0929 1 1
Leishmania major beta tubulin 0.0929 1 1
Leishmania major beta tubulin 0.0929 1 1
Echinococcus multilocularis Tubulin alpha 1 chain 0.0453 0.3696 0.3696
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.0453 0.3696 0.3696
Echinococcus granulosus tubulin alpha 3 chain 0.0453 0.3696 0.3696
Leishmania major beta tubulin 0.0929 1 1
Leishmania major beta tubulin 0.0929 1 1
Leishmania major beta tubulin 0.0929 1 1
Schistosoma mansoni alpha tubulin 0.0453 0.3696 0.3696
Wolbachia endosymbiont of Brugia malayi cell division protein FtsZ 0.0173 0 0.5
Echinococcus multilocularis tubulin subunit beta 0.0929 1 1
Echinococcus granulosus tubulin alpha chain 0.0453 0.3696 0.3696
Echinococcus multilocularis hypothetical protein 0.0453 0.3696 0.3696
Trypanosoma brucei beta tubulin 0.0399 0.299 0.299
Trypanosoma cruzi epsilon tubulin, putative 0.0399 0.299 0.299
Trypanosoma brucei beta tubulin 0.0929 1 1
Schistosoma mansoni tubulin subunit alpha 0.0453 0.3696 0.3696
Echinococcus granulosus beta tubulin 0.0929 1 1
Echinococcus multilocularis Tubulin beta 2C chain 0.0929 1 1
Trypanosoma brucei beta tubulin 0.0929 1 1
Schistosoma mansoni tubulin subunit beta 0.0929 1 1
Echinococcus multilocularis Tubulin beta 2C chain 0.0929 1 1
Leishmania major beta tubulin 0.0929 1 1
Plasmodium vivax tubulin alpha chain, putative 0.0453 0.3696 0.3696
Echinococcus multilocularis tubulin, beta 4A class IVa 0.0929 1 1
Trypanosoma brucei beta tubulin 0.0929 1 1
Leishmania major alpha tubulin 0.0453 0.3696 0.3696
Toxoplasma gondii beta tubulin 0.0929 1 1
Echinococcus multilocularis tubulin alpha 0.0399 0.299 0.299
Loa Loa (eye worm) tubulin beta-4 chain 0.0929 1 1
Trichomonas vaginalis tubulin beta chain, putative 0.0929 1 1
Brugia malayi tubulin alpha chain - mouse 0.0453 0.3696 0.3696
Loa Loa (eye worm) alpha-tubulin 0.0453 0.3696 0.3696
Trichomonas vaginalis tubulin alpha chain, putative 0.0226 0.0696 0.0696
Giardia lamblia Beta tubulin 0.0929 1 1
Echinococcus granulosus Tubulin beta 2C chain 0.0929 1 1
Schistosoma mansoni tubulin subunit beta 0.0929 1 1
Leishmania major alpha tubulin 0.0453 0.3696 0.3696
Echinococcus granulosus tubulin subunit beta 0.0929 1 1
Echinococcus multilocularis tubulin beta 1 chain 0.0929 1 1
Echinococcus multilocularis tubulin alpha chain 0.0453 0.3696 0.3696
Leishmania major alpha tubulin 0.0453 0.3696 0.3696

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.