Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | myelin transcription factor 1 myt1 | 0.0056 | 0.0877 | 0.0778 |
Mycobacterium tuberculosis | Probable lipase LipD | 0.0037 | 0.0474 | 0.0793 |
Mycobacterium tuberculosis | Conserved protein | 0.0037 | 0.0474 | 0.0793 |
Plasmodium vivax | hypothetical protein, conserved | 0.0037 | 0.0474 | 1 |
Mycobacterium tuberculosis | Conserved protein | 0.0037 | 0.0474 | 0.0793 |
Brugia malayi | mbt repeat family protein | 0.0049 | 0.0731 | 0.0744 |
Schistosoma mansoni | hypothetical protein | 0.0297 | 0.606 | 0.6017 |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.0037 | 0.0474 | 0.0658 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0037 | 0.0474 | 0.0658 |
Brugia malayi | Pre-SET motif family protein | 0.0213 | 0.426 | 0.4331 |
Schistosoma mansoni | scm-relatedprotein containing 4 mbt domains (sfmbt) | 0.0049 | 0.0731 | 0.0631 |
Echinococcus multilocularis | SAM and MBT domain containing protein | 0.0049 | 0.0731 | 0.0642 |
Onchocerca volvulus | 0.0037 | 0.0474 | 0.0431 | |
Echinococcus granulosus | histone lysine methyltransferase setb | 0.0031 | 0.0339 | 0.0239 |
Mycobacterium leprae | Probable lipase LipE | 0.0037 | 0.0474 | 0.5 |
Brugia malayi | Tyrosyl-DNA phosphodiesterase family protein | 0.0068 | 0.1134 | 0.1153 |
Loa Loa (eye worm) | hypothetical protein | 0.0037 | 0.0474 | 0.0482 |
Echinococcus granulosus | SAM and MBT domain containing protein | 0.0049 | 0.0731 | 0.0642 |
Entamoeba histolytica | tyrosyl-DNA phosphodiesterase, putative | 0.0068 | 0.1134 | 1 |
Echinococcus multilocularis | histone lysine methyltransferase setb histone lysine methyltransferase eggless | 0.0031 | 0.0339 | 0.0239 |
Loa Loa (eye worm) | hypothetical protein | 0.002 | 0.0107 | 0.0109 |
Trichomonas vaginalis | set domain proteins, putative | 0.0242 | 0.4892 | 0.8564 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0031 | 0.0339 | 0.0235 |
Brugia malayi | mbt repeat family protein | 0.0049 | 0.0731 | 0.0744 |
Brugia malayi | C2-HC type zinc finger protein C.e-MyT1 | 0.0056 | 0.0877 | 0.0891 |
Mycobacterium tuberculosis | Probable conserved lipoprotein | 0.0037 | 0.0474 | 0.0793 |
Brugia malayi | Pre-SET motif family protein | 0.0031 | 0.0339 | 0.0344 |
Mycobacterium ulcerans | lipase LipD | 0.0037 | 0.0474 | 0.0658 |
Echinococcus multilocularis | lamin | 0.0028 | 0.0275 | 0.0173 |
Echinococcus multilocularis | beta LACTamase domain containing family member | 0.0037 | 0.0474 | 0.0378 |
Schistosoma mansoni | histone-lysine n-methyltransferase suv9 | 0.0031 | 0.0339 | 0.0235 |
Echinococcus granulosus | transcription factor Dp 1 | 0.0039 | 0.0523 | 0.0428 |
Loa Loa (eye worm) | beta-LACTamase domain containing family member | 0.0037 | 0.0474 | 0.0482 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0037 | 0.0474 | 0.0658 |
Echinococcus multilocularis | lamin dm0 | 0.0028 | 0.0275 | 0.0173 |
Trypanosoma cruzi | tyrosyl-DNA Phosphodiesterase (Tdp1), putative | 0.0068 | 0.1134 | 1 |
Onchocerca volvulus | 0.0242 | 0.4892 | 1 | |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0037 | 0.0474 | 0.0371 |
Trypanosoma cruzi | tyrosyl-DNA Phosphodiesterase (Tdp1), putative | 0.0068 | 0.1134 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0031 | 0.0339 | 0.0344 |
Mycobacterium tuberculosis | Probable esterase LipL | 0.0037 | 0.0474 | 0.0793 |
Mycobacterium tuberculosis | Possible conserved lipoprotein LpqK | 0.0037 | 0.0474 | 0.0793 |
Brugia malayi | glutaminase DH11.1 | 0.028 | 0.5695 | 0.579 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0037 | 0.0474 | 0.3576 |
Toxoplasma gondii | ABC1 family protein | 0.0037 | 0.0474 | 1 |
Brugia malayi | Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative | 0.0037 | 0.0474 | 0.0482 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0031 | 0.0339 | 0.0235 |
Echinococcus multilocularis | histone acetyltransferase MYST2 | 0.0056 | 0.0877 | 0.0791 |
Brugia malayi | beta-lactamase family protein | 0.0037 | 0.0474 | 0.0482 |
Loa Loa (eye worm) | glutaminase 2 | 0.028 | 0.5695 | 0.579 |
Brugia malayi | intermediate filament protein | 0.0028 | 0.0275 | 0.028 |
Loa Loa (eye worm) | intermediate filament tail domain-containing protein | 0.0028 | 0.0275 | 0.028 |
Onchocerca volvulus | 0.0037 | 0.0474 | 0.0431 | |
Loa Loa (eye worm) | hypothetical protein | 0.0027 | 0.0265 | 0.0269 |
Loa Loa (eye worm) | glutaminase | 0.028 | 0.5695 | 0.579 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0031 | 0.0339 | 0.0235 |
Schistosoma mansoni | tyrosyl-DNA phosphodiesterase | 0.0068 | 0.1134 | 0.1039 |
Mycobacterium tuberculosis | Probable lipase LipE | 0.0037 | 0.0474 | 0.0793 |
Onchocerca volvulus | Polycomb protein Sfmbt homolog | 0.0049 | 0.0731 | 0.0988 |
Brugia malayi | beta-lactamase family protein | 0.0037 | 0.0474 | 0.0482 |
Loa Loa (eye worm) | hypothetical protein | 0.0056 | 0.0877 | 0.0891 |
Onchocerca volvulus | 0.0031 | 0.0339 | 0.0137 | |
Echinococcus granulosus | lamin | 0.0028 | 0.0275 | 0.0173 |
Loa Loa (eye worm) | ImpB/MucB/SamB family protein | 0.002 | 0.0107 | 0.0109 |
Loa Loa (eye worm) | mbt repeat family protein | 0.0049 | 0.0731 | 0.0744 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0037 | 0.0474 | 0.0371 |
Echinococcus multilocularis | endonuclease exonuclease phosphatase | 0.0192 | 0.3817 | 0.3813 |
Trypanosoma brucei | hypothetical protein, conserved | 0.0037 | 0.0474 | 0.3576 |
Loa Loa (eye worm) | pre-SET domain-containing protein family protein | 0.0213 | 0.426 | 0.4331 |
Echinococcus granulosus | tyrosyl DNA phosphodiesterase 1 | 0.0068 | 0.1134 | 0.1056 |
Schistosoma mansoni | glutaminase | 0.028 | 0.5695 | 0.5648 |
Brugia malayi | ImpB/MucB/SamB family protein | 0.002 | 0.0107 | 0.0109 |
Mycobacterium tuberculosis | Probable esterase/lipase LipP | 0.0037 | 0.0474 | 0.0793 |
Loa Loa (eye worm) | tyrosyl-DNA phosphodiesterase | 0.0068 | 0.1134 | 0.1153 |
Schistosoma mansoni | sex comb on midleg homolog | 0.0049 | 0.0731 | 0.0631 |
Brugia malayi | Intermediate filament tail domain containing protein | 0.0028 | 0.0275 | 0.028 |
Schistosoma mansoni | lamin | 0.0028 | 0.0275 | 0.017 |
Echinococcus granulosus | intermediate filament protein | 0.0028 | 0.0275 | 0.0173 |
Echinococcus granulosus | mitogen activated protein kinase kinase kinase | 0.0472 | 0.9835 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0037 | 0.0474 | 0.0482 |
Loa Loa (eye worm) | hypothetical protein | 0.0472 | 0.9835 | 1 |
Trichomonas vaginalis | glutaminase, putative | 0.028 | 0.5695 | 1 |
Mycobacterium tuberculosis | Possible penicillin-binding protein | 0.0235 | 0.4742 | 1 |
Mycobacterium ulcerans | glutaminase | 0.028 | 0.5695 | 1 |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.0037 | 0.0474 | 0.0658 |
Giardia lamblia | DINP protein human, muc B family | 0.002 | 0.0107 | 0.5 |
Echinococcus multilocularis | musashi | 0.0028 | 0.0275 | 0.0173 |
Mycobacterium ulcerans | hypothetical protein | 0.0037 | 0.0474 | 0.0658 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0037 | 0.0474 | 0.0658 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0037 | 0.0474 | 0.3576 |
Loa Loa (eye worm) | MBCTL1 | 0.0056 | 0.0877 | 0.0891 |
Loa Loa (eye worm) | hypothetical protein | 0.0049 | 0.0731 | 0.0744 |
Loa Loa (eye worm) | hypothetical protein | 0.0472 | 0.9835 | 1 |
Schistosoma mansoni | sex comb on midleg homolog | 0.0049 | 0.0731 | 0.0631 |
Leishmania major | hypothetical protein, conserved | 0.0037 | 0.0474 | 0.3576 |
Echinococcus granulosus | suppression of tumorigenicity 18 protein | 0.0056 | 0.0877 | 0.0791 |
Schistosoma mansoni | hypothetical protein | 0.0173 | 0.3409 | 0.3338 |
Brugia malayi | Protein kinase domain containing protein | 0.0472 | 0.9835 | 1 |
Brugia malayi | beta-lactamase | 0.0037 | 0.0474 | 0.0482 |
Trypanosoma brucei | tyrosyl-DNA Phosphodiesterase (Tdp1), putative | 0.0068 | 0.1134 | 1 |
Mycobacterium tuberculosis | Conserved protein | 0.0037 | 0.0474 | 0.0793 |
Mycobacterium leprae | conserved hypothetical protein | 0.0037 | 0.0474 | 0.5 |
Echinococcus multilocularis | histone lysine N methyltransferase SETMAR | 0.0031 | 0.0339 | 0.0239 |
Echinococcus multilocularis | tyrosyl DNA phosphodiesterase 1 | 0.0068 | 0.1134 | 0.1056 |
Echinococcus granulosus | 5'partial|histone lysine N methyltransferase SETDB2 | 0.0029 | 0.0315 | 0.0214 |
Mycobacterium ulcerans | esterase/lipase LipP | 0.0037 | 0.0474 | 0.0658 |
Echinococcus granulosus | beta LACTamase domain containing family member | 0.0037 | 0.0474 | 0.0378 |
Echinococcus granulosus | polycomb protein SCMH1 | 0.0049 | 0.0731 | 0.0642 |
Echinococcus granulosus | lamin dm0 | 0.0028 | 0.0275 | 0.0173 |
Schistosoma mansoni | lamin | 0.0028 | 0.0275 | 0.017 |
Mycobacterium tuberculosis | Probable hydrolase | 0.0037 | 0.0474 | 0.0793 |
Loa Loa (eye worm) | hypothetical protein | 0.0037 | 0.0474 | 0.0482 |
Leishmania major | tyrosyl-DNA phosphodiesterase 1 | 0.0068 | 0.1134 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0028 | 0.0275 | 0.028 |
Trichomonas vaginalis | esterase, putative | 0.0037 | 0.0474 | 0.0658 |
Loa Loa (eye worm) | TKL/MLK/LZK protein kinase | 0.0472 | 0.9835 | 1 |
Loa Loa (eye worm) | intermediate filament protein | 0.0028 | 0.0275 | 0.028 |
Brugia malayi | ImpB/MucB/SamB family protein | 0.002 | 0.0107 | 0.0109 |
Echinococcus multilocularis | transcription factor Dp 1 | 0.0039 | 0.0523 | 0.0428 |
Onchocerca volvulus | 0.0037 | 0.0474 | 0.0431 | |
Loa Loa (eye worm) | hypothetical protein | 0.0037 | 0.0474 | 0.0482 |
Loa Loa (eye worm) | beta-lactamase | 0.0037 | 0.0474 | 0.0482 |
Schistosoma mansoni | intermediate filament proteins | 0.0028 | 0.0275 | 0.017 |
Echinococcus granulosus | endonuclease exonuclease phosphatase | 0.0192 | 0.3817 | 0.3813 |
Onchocerca volvulus | 0.0049 | 0.0731 | 0.0988 | |
Echinococcus multilocularis | polycomb protein SCMH1 | 0.0049 | 0.0731 | 0.0642 |
Schistosoma mansoni | hypothetical protein | 0.0173 | 0.3409 | 0.3338 |
Mycobacterium ulcerans | fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE | 0.0037 | 0.0474 | 0.0658 |
Loa Loa (eye worm) | hypothetical protein | 0.0037 | 0.0474 | 0.0482 |
Echinococcus multilocularis | suppression of tumorigenicity 18 protein | 0.0056 | 0.0877 | 0.0791 |
Echinococcus granulosus | geminin | 0.0173 | 0.3409 | 0.3395 |
Echinococcus multilocularis | geminin | 0.0173 | 0.3409 | 0.3395 |
Mycobacterium ulcerans | beta-lactamase | 0.0037 | 0.0474 | 0.0658 |
Echinococcus granulosus | histone acetyltransferase MYST2 | 0.0056 | 0.0877 | 0.0791 |
Echinococcus multilocularis | mitogen activated protein kinase kinase kinase | 0.0472 | 0.9835 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0037 | 0.0474 | 0.0482 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
EC50 (functional) | > 10 ug ml-1 | Positive inotropic activity in spontaneously beating guinea pig atria | ChEMBL. | 3172122 |
ED20 (functional) | = 2 mg kg-1 | Effective dose for lowering blood pressure in anesthetized cat when administered intravenously | ChEMBL. | 3172122 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.