TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 438.581 | Formula: C26H35FN4O
H donors: 0 H acceptors: 1 LogP: 4.37 Rotable bonds: 8
Rule of 5 violations (Lipinski): 1
SMILES: CN(C(C1CCN(CC1)Cc1ccc(o1)C)Cc1ccc(cc1)F)Cc1cn(nc1C)C
InChi: 1S/C26H35FN4O/c1-19-5-10-25(32-19)18-31-13-11-22(12-14-31)26(15-21-6-8-24(27)9-7-21)29(3)16-23-17-30(4)28-20(23)2/h5-10,17,22,26H,11-16,18H2,1-4H3
InChiKey: UAXMQCPOWKACCY-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Loa Loa (eye worm)	neuropeptide F receptor	0.0044	0.0227	0.0206
Plasmodium vivax	hypothetical protein, conserved	0.0284	0.1665	1
Brugia malayi	G-protein coupled receptor	0.0044	0.0227	0.0222
Echinococcus granulosus	neuropeptide receptor A26	0.0044	0.0227	0.0216
Brugia malayi	hypothetical protein	0.0284	0.1665	0.1661
Schistosoma mansoni	sodium-dependent amino acid transporter	0.0284	0.1665	0.1656
Brugia malayi	hypothetical protein	0.0044	0.0227	0.0222
Brugia malayi	neuropeptide F receptor	0.0044	0.0227	0.0222
Echinococcus granulosus	neuropeptides capa receptor	0.0044	0.0227	0.0216
Echinococcus granulosus	G protein coupled 5 hydroxytryptamine receptor	0.0044	0.0227	0.0216
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0044	0.0227	0.0216
Echinococcus multilocularis	neuropeptide Y receptor	0.0044	0.0227	0.0216
Onchocerca volvulus		0.0242	0.1411	0.1318
Brugia malayi	hypothetical protein	0.0044	0.0227	0.0222
Loa Loa (eye worm)	hypothetical protein	0.0044	0.0227	0.0206
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0031	0.0146	0.0136
Echinococcus granulosus	alpha 1A adrenergic receptor	0.0044	0.0227	0.0216
Loa Loa (eye worm)	hypothetical protein	0.0044	0.0227	0.0206
Echinococcus granulosus	biogenic amine 5HT receptor	0.0418	0.2465	0.2457
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0031	0.0146	0.0136
Schistosoma mansoni	biogenic amine receptor	0.0044	0.0227	0.0216
Entamoeba histolytica	exodeoxyribonuclease III, putative	0.0019	0.0075	1
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0044	0.0227	0.0216
Loa Loa (eye worm)	unidentified vitellogenin-linked transcript protein 6	0.0044	0.0227	0.0206
Trichomonas vaginalis	phosphoenolpyruvate-protein phosphotransferase, putative	0.001	0.0022	0.0153
Brugia malayi	hypothetical protein	0.0044	0.0227	0.0222
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0044	0.0227	0.0216
Loa Loa (eye worm)	hypothetical protein	0.0044	0.0227	0.0206
Onchocerca volvulus	Peroxidase homolog	0.0524	0.3099	0.3024
Onchocerca volvulus		0.0044	0.0227	0.0121
Brugia malayi	G protein-coupled receptor	0.0044	0.0227	0.0222
Schistosoma mansoni	opsin-like receptor	0.0044	0.0227	0.0216
Echinococcus granulosus	somatostatin receptor	0.0044	0.0227	0.0216
Plasmodium vivax	pyruvate kinase, putative	0.0024	0.0107	0.0438
Loa Loa (eye worm)	Sodium:neurotransmitter symporter family protein	0.0284	0.1665	0.1647
Brugia malayi	CXXC zinc finger family protein	0.0029	0.0136	0.0131
Loa Loa (eye worm)	hypothetical protein	0.0044	0.0227	0.0206
Loa Loa (eye worm)	hypothetical protein	0.0524	0.3099	0.3084
Brugia malayi	Pre-SET motif family protein	0.0213	0.1235	0.1231
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0044	0.0227	0.0216
Echinococcus granulosus	7TM GPCR rhodopsin	0.0044	0.0227	0.0216
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0044	0.0227	0.0216
Loa Loa (eye worm)	hypothetical protein	0.0524	0.3099	0.3084
Echinococcus multilocularis	neuropeptide receptor	0.0044	0.0227	0.0216
Schistosoma mansoni	opsin-like receptor	0.0044	0.0227	0.0216
Echinococcus granulosus	tachykinin peptides receptor 99D	0.0044	0.0227	0.0216
Echinococcus multilocularis	g-protein coupled receptor	0.0044	0.0227	0.0216
Toxoplasma gondii	hypothetical protein	0.0284	0.1665	1
Echinococcus granulosus	g protein coupled receptor	0.0044	0.0227	0.0216
Schistosoma mansoni	ap endonuclease	0.0019	0.0075	0.0065
Echinococcus multilocularis	allatostatin A receptor	0.0044	0.0227	0.0216
Loa Loa (eye worm)	hypothetical protein	0.0524	0.3099	0.3084
Echinococcus multilocularis	sodium:chloride dependent neurotransmitter	0.0284	0.1665	0.1656
Trypanosoma cruzi	pyruvate kinase 2, putative	0.0024	0.0107	1
Schistosoma mansoni	neuropeptide receptor	0.0044	0.0227	0.0216
Echinococcus granulosus	7tm_1 domain containing protein	0.0044	0.0227	0.0216
Brugia malayi	Animal haem peroxidase family protein	0.0524	0.3099	0.3096
Echinococcus multilocularis	g protein coupled receptor	0.0044	0.0227	0.0216
Echinococcus granulosus	sex peptide receptor	0.0044	0.0227	0.0216
Loa Loa (eye worm)	gonadotropin-releasing hormone receptor 2	0.0044	0.0227	0.0206
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0044	0.0227	0.0216
Loa Loa (eye worm)	hypothetical protein	0.0044	0.0227	0.0206
Schistosoma mansoni	adenoreceptor	0.0044	0.0227	0.0216
Schistosoma mansoni	amine GPCR	0.0044	0.0227	0.0216
Echinococcus granulosus	dro:myosuppressin receptor	0.0044	0.0227	0.0216
Schistosoma mansoni	hypothetical protein	0.0044	0.0227	0.0216
Loa Loa (eye worm)	blistered cuticle protein 3	0.0524	0.3099	0.3084
Echinococcus multilocularis	g protein coupled receptor	0.0044	0.0227	0.0216
Echinococcus granulosus	tm gpcr rhodopsin	0.0044	0.0227	0.0216
Loa Loa (eye worm)	hypothetical protein	0.0044	0.0227	0.0206
Echinococcus granulosus	G protein coupled receptor 139	0.0044	0.0227	0.0216
Brugia malayi	Serotonin receptor	0.0044	0.0227	0.0222
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0044	0.0227	0.0216
Loa Loa (eye worm)	exodeoxyribonuclease III family protein	0.0019	0.0075	0.0054
Schistosoma mansoni	cpg binding protein	0.0029	0.0136	0.0125
Onchocerca volvulus	Peroxidasin homolog	0.0524	0.3099	0.3024
Echinococcus multilocularis	serotonin transporter	0.1676	1	1
Loa Loa (eye worm)	5-hydroxytryptamine 2C receptor	0.0044	0.0227	0.0206
Loa Loa (eye worm)	hypothetical protein	0.0044	0.0227	0.0206
Loa Loa (eye worm)	hypothetical protein	0.0524	0.3099	0.3084
Loa Loa (eye worm)	hypothetical protein	0.1676	1	1
Loa Loa (eye worm)	hypothetical protein	0.0044	0.0227	0.0206
Giardia lamblia	Pyruvate kinase	0.0013	0.0036	0.1633
Echinococcus multilocularis	orexin receptor type 2	0.0044	0.0227	0.0216
Onchocerca volvulus		0.0044	0.0227	0.0121
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0044	0.0227	0.0216
Loa Loa (eye worm)	hypothetical protein	0.0418	0.2465	0.2449
Brugia malayi	putative neuropeptide receptor	0.0044	0.0227	0.0222
Loa Loa (eye worm)	hypothetical protein	0.0044	0.0227	0.0206
Schistosoma mansoni	histamine h1 receptor	0.0044	0.0227	0.0216
Loa Loa (eye worm)	hypothetical protein	0.0524	0.3099	0.3084
Mycobacterium tuberculosis	Probable pyruvate kinase PykA	0.0024	0.0107	1
Loa Loa (eye worm)	animal heme peroxidase	0.0524	0.3099	0.3084
Brugia malayi	hypothetical protein	0.0044	0.0227	0.0222
Schistosoma mansoni	hypothetical protein	0.0044	0.0227	0.0216
Onchocerca volvulus		0.0044	0.0227	0.0121
Echinococcus multilocularis	sodium and chloride dependent glycine	0.0284	0.1665	0.1656
Echinococcus multilocularis	serotonin receptor	0.0418	0.2465	0.2457
Wolbachia endosymbiont of Brugia malayi	exonuclease III	0.0019	0.0075	1
Echinococcus granulosus	neuropeptide receptor	0.0044	0.0227	0.0216
Toxoplasma gondii	Sodium:neurotransmitter symporter family protein	0.0284	0.1665	1
Schistosoma mansoni	histamine-responsive GPCR (AAF21638)	0.0044	0.0227	0.0216
Onchocerca volvulus		0.0029	0.0136	0.0029
Loa Loa (eye worm)	hypothetical protein	0.0044	0.0227	0.0206
Schistosoma mansoni	sodium-dependent neurotransmitter transporter	0.0284	0.1665	0.1656
Echinococcus granulosus	sodium and chloride dependent glycine	0.0284	0.1665	0.1656
Echinococcus granulosus	neuropeptide s receptor	0.0044	0.0227	0.0216
Echinococcus granulosus	rhodopsin orphan GPCR	0.0044	0.0227	0.0216
Schistosoma mansoni	norepinephrine/norepinephrine transporter	0.0284	0.1665	0.1656
Loa Loa (eye worm)	hypothetical protein	0.0524	0.3099	0.3084
Loa Loa (eye worm)	hypothetical protein	0.0044	0.0227	0.0206
Onchocerca volvulus		0.0524	0.3099	0.3024
Loa Loa (eye worm)	norepinephrine transporter	0.1676	1	1
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0044	0.0227	0.0216
Leishmania major	pyruvate kinase	0.0024	0.0107	1
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0044	0.0227	0.0216
Loa Loa (eye worm)	hypothetical protein	0.0044	0.0227	0.0206
Trichomonas vaginalis	pyruvate, phosphate dikinase, chloroplast, putative	0.001	0.0022	0.0153
Brugia malayi	GnHR receptor homolog	0.0044	0.0227	0.0222
Loa Loa (eye worm)	serotonin transporter b	0.1676	1	1
Echinococcus granulosus	rhodopsin orphan GPCR	0.0044	0.0227	0.0216
Echinococcus granulosus	uncharacterized sodium dependent transporter	0.0284	0.1665	0.1656
Echinococcus granulosus	fmrfamide receptor	0.0044	0.0227	0.0216
Loa Loa (eye worm)	hypothetical protein	0.0044	0.0227	0.0206
Loa Loa (eye worm)	hypothetical protein	0.0044	0.0227	0.0206
Brugia malayi	follicle stimulating hormone receptor	0.0044	0.0227	0.0222
Echinococcus multilocularis	neuropeptides capa receptor	0.0044	0.0227	0.0216
Loa Loa (eye worm)	hypothetical protein	0.0044	0.0227	0.0206
Trypanosoma brucei	apurinic/apyrimidinic endonuclease, putative	0.0019	0.0075	0.6274
Treponema pallidum	exodeoxyribonuclease (exoA)	0.0019	0.0075	0.0054
Schistosoma mansoni	neuropeptide F-like receptor	0.0044	0.0227	0.0216
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0044	0.0227	0.0216
Brugia malayi	G-protein-linked acetylcholine receptor protein 2, putative	0.0044	0.0227	0.0222
Echinococcus multilocularis	sex peptide receptor	0.0044	0.0227	0.0216
Loa Loa (eye worm)	hypothetical protein	0.0284	0.1665	0.1647
Loa Loa (eye worm)	hypothetical protein	0.0044	0.0227	0.0206
Echinococcus granulosus	neuropeptide FF receptor 2	0.0044	0.0227	0.0216
Echinococcus multilocularis	neuropeptide receptor A26	0.0044	0.0227	0.0216
Echinococcus granulosus	uncharacterized sodium dependent transporter	0.0284	0.1665	0.1656
Schistosoma mansoni	cpg binding protein	0.0031	0.0146	0.0135
Loa Loa (eye worm)	hypothetical protein	0.0044	0.0227	0.0206
Mycobacterium ulcerans	exodeoxyribonuclease III protein XthA	0.0019	0.0075	0.6274
Brugia malayi	hypothetical protein	0.0044	0.0227	0.0222
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0044	0.0227	0.0216
Echinococcus granulosus	sodium and chloride dependent glycine	0.0284	0.1665	0.1656
Loa Loa (eye worm)	hypothetical protein	0.0284	0.1665	0.1647
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease, putative	0.0019	0.0075	0.6274
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0044	0.0227	0.0216
Trichomonas vaginalis	ap endonuclease, putative	0.0019	0.0075	0.0532
Loa Loa (eye worm)	hypothetical protein	0.0044	0.0227	0.0206
Entamoeba histolytica	pyruvate kinase, putative	0.0017	0.0063	0.7648
Plasmodium falciparum	amino acid transporter, putative	0.0284	0.1665	1
Brugia malayi	hypothetical protein	0.0044	0.0227	0.0222
Loa Loa (eye worm)	hypothetical protein	0.0524	0.3099	0.3084
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease	0.0019	0.0075	0.6274
Onchocerca volvulus		0.0044	0.0227	0.0121
Loa Loa (eye worm)	hypothetical protein	0.0418	0.2465	0.2449
Echinococcus multilocularis	DNA (apurinic or apyrimidinic site) lyase	0.0019	0.0075	0.0065
Mycobacterium tuberculosis	Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI)	0.0019	0.0075	0.6274
Trichomonas vaginalis	pyruvate, phosphate dikinase, chloroplast, putative	0.001	0.0022	0.0153
Echinococcus granulosus	rhodopsin orphan GPCR	0.0044	0.0227	0.0216
Onchocerca volvulus		0.0031	0.0146	0.004
Trypanosoma brucei	pyruvate kinase 1, putative	0.0024	0.0107	1
Loa Loa (eye worm)	hypothetical protein	0.0284	0.1665	0.1647
Echinococcus multilocularis	fmrfamide receptor	0.0044	0.0227	0.0216
Schistosoma mansoni	sodium/chloride dependent transporter	0.1676	1	1
Echinococcus multilocularis	7TM GPCR, rhodopsin	0.0044	0.0227	0.0216
Echinococcus multilocularis	serotonin receptor	0.0418	0.2465	0.2457
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0031	0.0146	0.0136
Schistosoma mansoni	sodium-dependent neurotransmitter transporter	0.0284	0.1665	0.1656
Schistosoma mansoni	peroxidasin	0.0524	0.3099	0.3092
Brugia malayi	Pyruvate kinase, muscle isozyme	0.0024	0.0107	0.0102
Loa Loa (eye worm)	hypothetical protein	0.0044	0.0227	0.0206
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0044	0.0227	0.0216
Echinococcus multilocularis	neuropeptide Y receptor	0.0044	0.0227	0.0216
Schistosoma mansoni	amine GPCR	0.0044	0.0227	0.0216
Onchocerca volvulus		0.0284	0.1665	0.1574
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0044	0.0227	0.0216
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0044	0.0227	0.0216
Echinococcus multilocularis	cpg binding protein	0.0031	0.0146	0.0135
Brugia malayi	Peroxidasin	0.0524	0.3099	0.3096
Loa Loa (eye worm)	hypothetical protein	0.0044	0.0227	0.0206
Echinococcus granulosus	rhodopsin orphan GPCR	0.0044	0.0227	0.0216
Giardia lamblia	Pyruvate kinase	0.0024	0.0107	1
Loa Loa (eye worm)	animal heme peroxidase	0.0524	0.3099	0.3084
Schistosoma mansoni	cpg binding protein	0.0031	0.0146	0.0135
Echinococcus granulosus	biogenic amine 5HT receptor	0.0044	0.0227	0.0216
Echinococcus multilocularis	G-protein coupled receptor, putative	0.0044	0.0227	0.0216
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0044	0.0227	0.0216
Echinococcus multilocularis	g protein coupled receptor	0.0044	0.0227	0.0216
Echinococcus granulosus	g protein coupled receptor	0.0044	0.0227	0.0216
Loa Loa (eye worm)	hypothetical protein	0.0044	0.0227	0.0206
Trypanosoma cruzi	pyruvate kinase 2, putative	0.0024	0.0107	1
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0044	0.0227	0.0216
Schistosoma mansoni	neuropeptide receptor	0.0044	0.0227	0.0216
Leishmania major	pyruvate kinase	0.0024	0.0107	1
Plasmodium falciparum	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	0.0019	0.0075	0.0243
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0044	0.0227	0.0216
Brugia malayi	Serotonin receptor	0.1591	0.9493	0.9492
Loa Loa (eye worm)	hypothetical protein	0.0044	0.0227	0.0206
Brugia malayi	ORL1-like opioid receptor	0.0044	0.0227	0.0222
Toxoplasma gondii	histone lysine methyltransferase SET1	0.0057	0.0299	0.1619
Schistosoma mansoni	peroxidasin	0.0524	0.3099	0.3092
Echinococcus multilocularis	histone lysine N methyltransferase MLL3	0.001	0.0021	0.0011
Toxoplasma gondii	hypothetical protein	0.0284	0.1665	1
Brugia malayi	larval opioid receptor	0.0044	0.0227	0.0222
Loa Loa (eye worm)	pyruvate kinase	0.0024	0.0107	0.0086
Brugia malayi	Dopamine receptor protein 2	0.0044	0.0227	0.0222
Echinococcus granulosus	peroxidasin	0.0524	0.3099	0.3092
Echinococcus granulosus	neuropeptides capa receptor	0.0044	0.0227	0.0216
Schistosoma mansoni	sodium/chloride dependent transporter	0.0284	0.1665	0.1656
Echinococcus multilocularis	fmrfamide receptor	0.0044	0.0227	0.0216
Trichomonas vaginalis	pyruvate, phosphate dikinase, chloroplast, putative	0.001	0.0022	0.0153
Loa Loa (eye worm)	hypothetical protein	0.0044	0.0227	0.0206
Schistosoma mansoni	neuropeptide receptor	0.0044	0.0227	0.0216
Loa Loa (eye worm)	hypothetical protein	0.0524	0.3099	0.3084
Loa Loa (eye worm)	CXXC zinc finger family protein	0.0029	0.0136	0.0115
Brugia malayi	AKH receptor	0.0044	0.0227	0.0222
Schistosoma mansoni	opsin-like receptor	0.0044	0.0227	0.0216
Echinococcus multilocularis	G protein coupled receptor 139	0.0044	0.0227	0.0216
Onchocerca volvulus		0.0044	0.0227	0.0121
Loa Loa (eye worm)	hypothetical protein	0.0524	0.3099	0.3084
Loa Loa (eye worm)	hypothetical protein	0.0284	0.1665	0.1647
Echinococcus granulosus	pyruvate kinase	0.0013	0.0036	0.0025
Echinococcus multilocularis	pyruvate kinase	0.0013	0.0036	0.0025
Brugia malayi	putative neuropeptide receptor NPR1	0.0044	0.0227	0.0222
Onchocerca volvulus		0.0044	0.0227	0.0121
Loa Loa (eye worm)	Sodium:neurotransmitter symporter family protein	0.0284	0.1665	0.1647
Echinococcus multilocularis	pyruvate kinase	0.0013	0.0036	0.0025
Schistosoma mansoni	amine GPCR	0.0044	0.0227	0.0216
Brugia malayi	Serotonin/octopamine receptor family protein 7	0.0333	0.1953	0.1949
Echinococcus granulosus	cpg binding protein	0.0031	0.0146	0.0135
Brugia malayi	Unidentified vitellogenin-linked transcript protein 6, putative	0.0044	0.0227	0.0222
Schistosoma mansoni	sodium/chloride dependent neurotransmitter transporter	0.0284	0.1665	0.1656
Trypanosoma brucei	pyruvate kinase 1	0.0024	0.0107	1
Echinococcus multilocularis	neuropeptide FF receptor 2	0.0044	0.0227	0.0216
Brugia malayi	hypothetical protein	0.0044	0.0227	0.0222
Chlamydia trachomatis	pyruvate kinase	0.0024	0.0107	0.0519
Schistosoma mansoni	pyruvate kinase	0.0024	0.0107	0.0096
Echinococcus multilocularis	pyruvate kinase	0.0013	0.0036	0.0025
Brugia malayi	Blistered cuticle protein 3	0.0524	0.3099	0.3096
Loa Loa (eye worm)	G-protein coupled receptor	0.0044	0.0227	0.0206
Loa Loa (eye worm)	hypothetical protein	0.0284	0.1665	0.1647
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0063	0.0339	0.0329
Toxoplasma gondii	exonuclease III APE	0.0019	0.0075	0.0243
Loa Loa (eye worm)	hypothetical protein	0.0524	0.3099	0.3084
Loa Loa (eye worm)	hypothetical protein	0.0044	0.0227	0.0206
Echinococcus granulosus	rhodopsin orphan GPCR	0.0044	0.0227	0.0216
Brugia malayi	G protein-coupled receptor F59B2.13	0.0044	0.0227	0.0222
Loa Loa (eye worm)	hypothetical protein	0.0044	0.0227	0.0206
Schistosoma mansoni	biogenic amine receptor	0.0044	0.0227	0.0216
Echinococcus multilocularis	tachykinin peptides receptor 99D	0.0044	0.0227	0.0216
Trichomonas vaginalis	pyruvate, phosphate dikinase, chloroplast, putative	0.001	0.0022	0.0153
Schistosoma mansoni	myosin xvIII	0.0044	0.0227	0.0216
Brugia malayi	G-protein coupled receptor	0.0044	0.0227	0.0222
Echinococcus multilocularis	somatostatin receptor	0.0044	0.0227	0.0216
Plasmodium falciparum	transporter, putative	0.0284	0.1665	1
Brugia malayi	Tachykinin-like peptides receptor 99D	0.0044	0.0227	0.0222
Trichomonas vaginalis	phosphoenolpyruvate-protein phosphotransferase, putative	0.001	0.0022	0.0153
Brugia malayi	hypothetical protein	0.0044	0.0227	0.0222
Onchocerca volvulus		0.0044	0.0227	0.0121
Brugia malayi	Animal haem peroxidase family protein	0.0524	0.3099	0.3096
Schistosoma mansoni	growth hormone secretagogue receptor	0.0044	0.0227	0.0216
Schistosoma mansoni	thyrotropin-releasing hormone receptor	0.0044	0.0227	0.0216
Echinococcus multilocularis	thyrotropin releasing hormone receptor	0.0044	0.0227	0.0216
Trichomonas vaginalis	set domain proteins, putative	0.0242	0.1411	1
Loa Loa (eye worm)	hypothetical protein	0.1676	1	1
Schistosoma mansoni	ancient conserved domain protein 2 (cyclin m2)	0.0044	0.0227	0.0216
Echinococcus granulosus	tm gpcr rhodopsin	0.0044	0.0227	0.0216
Schistosoma mansoni	neuropeptide F-like receptor	0.0044	0.0227	0.0216
Plasmodium falciparum	pyruvate kinase	0.0024	0.0107	0.0438
Toxoplasma gondii	histone lysine methyltransferase SET/SUV39	0.0031	0.0146	0.0681
Echinococcus multilocularis	uncharacterized sodium dependent transporter	0.0284	0.1665	0.1656
Loa Loa (eye worm)	neuropeptide F receptor	0.0044	0.0227	0.0206
Loa Loa (eye worm)	hypothetical protein	0.0044	0.0227	0.0206
Schistosoma mansoni	pyruvate kinase	0.0013	0.0036	0.0025
Echinococcus granulosus	serotonin transporter	0.1676	1	1
Loa Loa (eye worm)	hypothetical protein	0.0524	0.3099	0.3084
Leishmania major	apurinic/apyrimidinic endonuclease-redox protein	0.0019	0.0075	0.6274
Onchocerca volvulus	Neuropeptide F receptor homolog	0.0044	0.0227	0.0121
Brugia malayi	Animal haem peroxidase family protein	0.0524	0.3099	0.3096
Echinococcus multilocularis	peptide (allatostatin:somatostatin)	0.0044	0.0227	0.0216
Trichomonas vaginalis	pyruvate kinase, putative	0.0024	0.0107	0.0758
Loa Loa (eye worm)	hypothetical protein	0.0044	0.0227	0.0206
Loa Loa (eye worm)	hypothetical protein	0.0044	0.0227	0.0206
Schistosoma mansoni	norepinephrine/norepinephrine transporter	0.1676	1	1
Loa Loa (eye worm)	hypothetical protein	0.0044	0.0227	0.0206
Schistosoma mansoni	sodium-dependent neurotransmitter transporter	0.0284	0.1665	0.1656
Loa Loa (eye worm)	hypothetical protein	0.0044	0.0227	0.0206
Loa Loa (eye worm)	animal heme peroxidase	0.0524	0.3099	0.3084
Echinococcus granulosus	hypothetical protein	0.1458	0.8693	0.8692
Brugia malayi	Dopamine receptor protein 1	0.0044	0.0227	0.0222
Brugia malayi	Dopamine receptor	0.0044	0.0227	0.0222
Echinococcus granulosus	pyruvate kinase	0.0024	0.0107	0.0096
Echinococcus multilocularis	neuropeptide receptor	0.0044	0.0227	0.0216
Plasmodium vivax	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	0.0019	0.0075	0.0243
Trichomonas vaginalis	pyruvate, phosphate dikinase, chloroplast, putative	0.001	0.0022	0.0153
Brugia malayi	exodeoxyribonuclease III family protein	0.0019	0.0075	0.0071
Brugia malayi	gonadotropin-releasing hormone receptor 2	0.0044	0.0227	0.0222
Echinococcus granulosus	sodium dependent neurotransmitter transporter	0.0284	0.1665	0.1656
Loa Loa (eye worm)	hypothetical protein	0.0284	0.1665	0.1647
Chlamydia trachomatis	Ssodium-dependent amino acid transporter	0.0284	0.1665	1
Echinococcus granulosus	orexin receptor type 2	0.0044	0.0227	0.0216
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0044	0.0227	0.0216
Loa Loa (eye worm)	hypothetical protein	0.0044	0.0227	0.0206
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.0044	0.0227	0.0206
Echinococcus granulosus	pyruvate kinase	0.0013	0.0036	0.0025
Schistosoma mansoni	norepinephrine/norepinephrine transporter	0.0284	0.1665	0.1656
Echinococcus granulosus	tm gpcr rhodopsin	0.0044	0.0227	0.0216
Echinococcus granulosus	thyrotropin releasing hormone receptor	0.0044	0.0227	0.0216
Schistosoma mansoni	hypothetical protein	0.0044	0.0227	0.0216
Loa Loa (eye worm)	hypothetical protein	0.0524	0.3099	0.3084
Loa Loa (eye worm)	hypothetical protein	0.0044	0.0227	0.0206
Onchocerca volvulus		0.0524	0.3099	0.3024
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0044	0.0227	0.0216
Toxoplasma gondii	pyruvate kinase PyK1	0.0024	0.0107	0.0438
Toxoplasma gondii	Sodium:neurotransmitter symporter family protein	0.0284	0.1665	1
Echinococcus multilocularis	neuropeptides capa receptor	0.0044	0.0227	0.0216
Brugia malayi	hypothetical protein	0.0044	0.0227	0.0222
Echinococcus multilocularis	peroxidasin	0.0524	0.3099	0.3092
Echinococcus granulosus	neuropeptide Y receptor	0.0044	0.0227	0.0216
Onchocerca volvulus		0.0044	0.0227	0.0121
Loa Loa (eye worm)	hypothetical protein	0.0044	0.0227	0.0206
Onchocerca volvulus		0.0044	0.0227	0.0121
Schistosoma mansoni	neuropeptide receptor	0.0044	0.0227	0.0216
Schistosoma mansoni	sodium/chloride dependent transporter	0.0284	0.1665	0.1656
Schistosoma mansoni	sodium/chloride dependent neurotransmitter transporter	0.0284	0.1665	0.1656
Loa Loa (eye worm)	hypothetical protein	0.0333	0.1953	0.1936
Schistosoma mansoni	peptide (allatostatin/somatostatin)-like receptor	0.0044	0.0227	0.0216
Brugia malayi	neuropeptide F receptor	0.0044	0.0227	0.0222
Loa Loa (eye worm)	G-protein coupled receptor	0.0044	0.0227	0.0206
Onchocerca volvulus		0.0044	0.0227	0.0121
Echinococcus granulosus	pyruvate kinase	0.0024	0.0107	0.0096
Loa Loa (eye worm)	hypothetical protein	0.0044	0.0227	0.0206
Echinococcus multilocularis	dro:myosuppressin receptor	0.0044	0.0227	0.0216
Loa Loa (eye worm)	melatonin receptor type 1A	0.0044	0.0227	0.0206
Echinococcus multilocularis	histone lysine N methyltransferase SETMAR	0.0031	0.0146	0.0136
Onchocerca volvulus		0.0044	0.0227	0.0121
Echinococcus multilocularis	sodium and chloride dependent glycine	0.0284	0.1665	0.1656
Onchocerca volvulus		0.1676	1	1
Loa Loa (eye worm)	hypothetical protein	0.0044	0.0227	0.0206
Loa Loa (eye worm)	hypothetical protein	0.0044	0.0227	0.0206
Echinococcus granulosus	growth hormone secretagogue receptor type 1	0.0044	0.0227	0.0216
Trichomonas vaginalis	pyruvate kinase, putative	0.0024	0.0107	0.0758
Trichomonas vaginalis	pyruvate, phosphate dikinase, chloroplast, putative	0.001	0.0022	0.0153
Brugia malayi	Sodium:neurotransmitter symporter family protein 1, putative	0.0284	0.1665	0.1661
Echinococcus granulosus	pyruvate kinase	0.0013	0.0036	0.0025
Schistosoma mansoni	muscarinic acetylcholine (GAR) receptor	0.0044	0.0227	0.0216
Onchocerca volvulus		0.0284	0.1665	0.1574
Loa Loa (eye worm)	hypothetical protein	0.0333	0.1953	0.1936
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0146	0.0125
Onchocerca volvulus		0.0524	0.3099	0.3024
Brugia malayi	Sodium:neurotransmitter symporter family protein	0.0284	0.1665	0.1661
Schistosoma mansoni	amine GPCR	0.0044	0.0227	0.0216
Loa Loa (eye worm)	solute carrier family 6 member 4	0.1676	1	1
Echinococcus multilocularis	pyroglutamylated rfamide peptide receptor	0.0044	0.0227	0.0216
Echinococcus multilocularis	histone lysine methyltransferase setb histone lysine methyltransferase eggless	0.0031	0.0146	0.0136
Brugia malayi	Melatonin receptor type 1A	0.0044	0.0227	0.0222
Brugia malayi	Sodium:neurotransmitter symporter family protein	0.0284	0.1665	0.1661
Loa Loa (eye worm)	hypothetical protein	0.0044	0.0227	0.0206
Schistosoma mansoni	ap endonuclease	0.0019	0.0075	0.0065
Schistosoma mansoni	pyruvate kinase	0.0024	0.0107	0.0096
Brugia malayi	sulfakinin receptor protein	0.0044	0.0227	0.0222
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0107	0.0086
Brugia malayi	Animal haem peroxidase family protein	0.0524	0.3099	0.3096
Schistosoma mansoni	hypothetical protein	0.0044	0.0227	0.0216
Trichomonas vaginalis	phosphoenolpyruvate-protein phosphotransferase, putative	0.001	0.0022	0.0153
Echinococcus granulosus	pyroglutamylated rfamide peptide receptor	0.0044	0.0227	0.0216
Echinococcus granulosus	rhodopsin orphan GPCR	0.0044	0.0227	0.0216
Loa Loa (eye worm)	hypothetical protein	0.0524	0.3099	0.3084
Echinococcus multilocularis	pyruvate kinase	0.0024	0.0107	0.0096
Onchocerca volvulus		0.0044	0.0227	0.0121
Schistosoma mansoni	biogenic amine receptor	0.0044	0.0227	0.0216
Loa Loa (eye worm)	pyruvate kinase-PB	0.0017	0.0063	0.0041
Echinococcus multilocularis	G protein coupled 5 hydroxytryptamine receptor	0.0044	0.0227	0.0216
Echinococcus granulosus	histone lysine methyltransferase setb	0.0031	0.0146	0.0136
Echinococcus multilocularis	sodium dependent neurotransmitter transporter	0.0284	0.1665	0.1656
Onchocerca volvulus		0.0044	0.0227	0.0121
Schistosoma mansoni	biogenic amine (octopamine/dopamine) receptor	0.0333	0.1953	0.1945
Echinococcus granulosus	neuropeptide receptor	0.0044	0.0227	0.0216
Onchocerca volvulus	Dopamine\/Ecdysteroid receptor homolog	0.0044	0.0227	0.0121
Brugia malayi	F/Y-rich N-terminus family protein	0.001	0.0021	0.0016
Loa Loa (eye worm)	hypothetical protein	0.0044	0.0227	0.0206
Brugia malayi	RE15519p	0.0044	0.0227	0.0222
Echinococcus granulosus	5'partial\|histone lysine N methyltransferase SETDB2	0.0029	0.0136	0.0125
Schistosoma mansoni	alpha-1 adrenergic receptor	0.0044	0.0227	0.0216
Brugia malayi	Dopamine receptor protein 1, putative (partial)	0.0044	0.0227	0.0222
Onchocerca volvulus		0.0284	0.1665	0.1574
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0044	0.0227	0.0216
Mycobacterium ulcerans	pyruvate kinase	0.0024	0.0107	1
Onchocerca volvulus	Dual oxidase homolog	0.0524	0.3099	0.3024
Loa Loa (eye worm)	hypothetical protein	0.0524	0.3099	0.3084
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0044	0.0227	0.0216
Loa Loa (eye worm)	hypothetical protein	0.0044	0.0227	0.0206
Schistosoma mansoni	histone-lysine n-methyltransferase suv9	0.0031	0.0146	0.0136
Schistosoma mansoni	peptide (FMRFamide/neurokinin-3)-like receptor	0.0044	0.0227	0.0216
Echinococcus multilocularis	pyruvate kinase	0.0019	0.0076	0.0066
Loa Loa (eye worm)	G-protein-linked acetylcholine receptor protein 2	0.0044	0.0227	0.0206
Onchocerca volvulus		0.0044	0.0227	0.0121
Trichomonas vaginalis	ap endonuclease, putative	0.0019	0.0075	0.0532
Brugia malayi	Sodium:neurotransmitter symporter family protein	0.0284	0.1665	0.1661
Toxoplasma gondii	Sodium:neurotransmitter symporter family protein	0.0284	0.1665	1
Echinococcus granulosus	g protein coupled receptor	0.0044	0.0227	0.0216
Echinococcus granulosus	DNA apurinic or apyrimidinic site lyase	0.0019	0.0075	0.0065
Treponema pallidum	sodium- and chloride- dependent transporter	0.1676	1	1
Brugia malayi	Animal haem peroxidase family protein	0.0524	0.3099	0.3096
Brugia malayi	Pyruvate kinase, M2 isozyme	0.0024	0.0107	0.0102
Schistosoma mansoni	peptide (allatostatin)-like receptor	0.0044	0.0227	0.0216
Onchocerca volvulus	Chorion peroxidase homolog	0.0524	0.3099	0.3024
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0044	0.0227	0.0216
Onchocerca volvulus	Peroxidase homolog	0.0524	0.3099	0.3024
Brugia malayi	hypothetical protein	0.0044	0.0227	0.0222
Loa Loa (eye worm)	hypothetical protein	0.0044	0.0227	0.0206
Echinococcus granulosus	rhodopsin orphan GPCR	0.0044	0.0227	0.0216
Echinococcus multilocularis	biogenic amine (5HT) receptor	0.0044	0.0227	0.0216
Echinococcus granulosus	histone lysine N methyltransferase MLL3	0.001	0.0021	0.0011
Echinococcus multilocularis	conserved hypothetical protein	0.1413	0.8427	0.8425
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0044	0.0227	0.0216
Loa Loa (eye worm)	hypothetical protein	0.0284	0.1665	0.1647
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0044	0.0227	0.0216
Loa Loa (eye worm)	hypothetical protein	0.0044	0.0227	0.0206
Plasmodium vivax	SET domain protein, putative	0.0031	0.0146	0.0681
Brugia malayi	Pre-SET motif family protein	0.0031	0.0146	0.0142
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0044	0.0227	0.0216
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0044	0.0227	0.0216
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0063	0.0041
Echinococcus granulosus	sodium:chloride dependent neurotransmitter	0.0284	0.1665	0.1656
Loa Loa (eye worm)	pyruvate kinase	0.0024	0.0107	0.0086
Echinococcus multilocularis	neuropeptide s receptor	0.0044	0.0227	0.0216
Onchocerca volvulus		0.0044	0.0227	0.0121
Echinococcus multilocularis	pyruvate kinase	0.0024	0.0107	0.0096
Echinococcus granulosus	g-protein coupled receptor	0.0044	0.0227	0.0216
Schistosoma mansoni	amine GPCR	0.0044	0.0227	0.0216
Loa Loa (eye worm)	animal heme peroxidase	0.0524	0.3099	0.3084
Echinococcus granulosus	serotonin receptor	0.0044	0.0227	0.0216
Onchocerca volvulus		0.0044	0.0227	0.0121
Loa Loa (eye worm)	pre-SET domain-containing protein family protein	0.0213	0.1235	0.1217
Brugia malayi	hypothetical protein	0.0524	0.3099	0.3096
Echinococcus granulosus	allatostatin A receptor	0.0044	0.0227	0.0216
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0044	0.0227	0.0216
Trichomonas vaginalis	pyruvate, phosphate dikinase, chloroplast, putative	0.001	0.0022	0.0153
Loa Loa (eye worm)	TYRA-2 protein	0.0044	0.0227	0.0206
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0044	0.0227	0.0216
Onchocerca volvulus	Peroxidasin homolog	0.0524	0.3099	0.3024
Echinococcus granulosus	neuropeptide Y receptor	0.0044	0.0227	0.0216
Loa Loa (eye worm)	pyruvate kinase	0.0024	0.0107	0.0086
Onchocerca volvulus		0.0044	0.0227	0.0121
Plasmodium vivax	amine transporter, putative	0.0284	0.1665	1
Schistosoma mansoni	neuropeptide f receptor 76f	0.0044	0.0227	0.0216
Echinococcus granulosus	peptide allatostatin:somatostatin	0.0044	0.0227	0.0216
Echinococcus multilocularis	alpha 1A adrenergic receptor	0.0044	0.0227	0.0216
Loa Loa (eye worm)	hypothetical protein	0.1676	1	1
Schistosoma mansoni	sodium/chloride dependent neurotransmitter transporter	0.0284	0.1665	0.1656
Mycobacterium leprae	Probable pyruvate kinase PykA	0.0024	0.0107	1
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0418	0.2465	0.2457
Giardia lamblia	Endonuclease/Exonuclease/phosphatase	0.0019	0.0075	0.6274
Echinococcus multilocularis	growth hormone secretagogue receptor type 1	0.0044	0.0227	0.0216

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

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Bibliographic References

No literature references available for this target.

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Detailed information for compound 816086