Detailed information for compound 816203

Basic information

Technical information
  • TDR Targets ID: 816203
  • Name: tert-butyl 2-[(6-methyl-1,3-benzothiazol-2-yl )carbamoyl]pyrrolidine-1-carboxylate
  • MW: 361.459 | Formula: C18H23N3O3S
  • H donors: 1 H acceptors: 3 LogP: 3.69 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(C1CCCN1C(=O)OC(C)(C)C)Nc1nc2c(s1)cc(cc2)C
  • InChi: 1S/C18H23N3O3S/c1-11-7-8-12-14(10-11)25-16(19-12)20-15(22)13-6-5-9-21(13)17(23)24-18(2,3)4/h7-8,10,13H,5-6,9H2,1-4H3,(H,19,20,22)
  • InChiKey: OOXGPUOQOTWUAC-UHFFFAOYSA-N  


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Synonyms

  • 2-[[(6-methyl-1,3-benzothiazol-2-yl)amino]-oxomethyl]-1-pyrrolidinecarboxylic acid tert-butyl ester
  • 2-[(6-methyl-1,3-benzothiazol-2-yl)carbamoyl]pyrrolidine-1-carboxylic acid tert-butyl ester
  • 5920-21-8
  • Pyrrolidine-1-carboxylic acid, 2-(6-methyl-2-benzothiazolyl)aminocarbonyl-, tert-butyl ester
  • tert-Butyl 2-([(6-methyl-1,3-benzothiazol-2-yl)amino]carbonyl)-1-pyrrolidinecarboxylate
  • MLS000710594
  • SMR000280361
  • Oprea1_081782
  • CBMicro_008382
  • Oprea1_788808
  • BAS 00524704
  • BIM-0008593.P001

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Photinus pyralis Luciferin 4-monooxygenase Starlite/ChEMBL No references
Homo sapiens glucagon-like peptide 1 receptor Starlite/ChEMBL No references
Homo sapiens nuclear factor, erythroid 2-like 2 Starlite/ChEMBL No references
Homo sapiens glycoprotein hormones, alpha polypeptide Starlite/ChEMBL No references
Homo sapiens GNAS complex locus Starlite/ChEMBL No references
Homo sapiens apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3D Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania major 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans fatty-acid-CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania infantum 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania braziliensis 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium knowlesi acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Brugia malayi AMP-binding enzyme family protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Brugia malayi AMP-binding enzyme family protein Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium vivax acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Onchocerca volvulus Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania infantum 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Entamoeba histolytica acyl-coA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania infantum 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania major 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania mexicana 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Mycobacterium ulcerans acyl-CoA synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Schistosoma japonicum ko:K04632 guanine nucleotide binding protein (G protein), alpha stimulating, putative Get druggable targets OG5_131088 All targets in OG5_131088
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans acyl-CoA synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans long-chain fatty-acid CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania donovani 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania infantum 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Plasmodium falciparum acyl-CoA synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania mexicana 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania mexicana 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Entamoeba histolytica acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Leishmania major 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium yoelii peroxisomal-coenzyme a synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative Get druggable targets OG5_131088 All targets in OG5_131088
Leishmania donovani 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium berghei acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain Get druggable targets OG5_131088 All targets in OG5_131088
Mycobacterium ulcerans acyl-CoA synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Brugia malayi AMP-binding enzyme family protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans fatty-acid-CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Entamoeba histolytica acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) Luciferin 4-monooxygenase   550 aa 509 aa 22.6 %
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD34 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 537 aa 20.9 %
Mycobacterium ulcerans putative fatty-acid--CoA ligase Luciferin 4-monooxygenase   550 aa 576 aa 20.8 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 494 aa 24.3 %
Trypanosoma brucei fatty acyl CoA synthetase 3 Luciferin 4-monooxygenase   550 aa 491 aa 23.6 %
Neospora caninum acetyl-coenzyme a synthetase, putative Luciferin 4-monooxygenase   550 aa 549 aa 20.9 %
Dictyostelium discoideum AMP-dependent synthetase and ligase domain-containing protein Luciferin 4-monooxygenase   550 aa 531 aa 19.0 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 497 aa 19.3 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 499 aa 19.2 %
Mycobacterium leprae Probable long-chain-fatty-acid-CoA ligase FadD15 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Luciferin 4-monooxygenase   550 aa 484 aa 23.3 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 542 aa 18.3 %
Dictyostelium discoideum AMP-dependent synthetase and ligase domain-containing protein Luciferin 4-monooxygenase   550 aa 550 aa 20.9 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 542 aa 22.1 %
Mycobacterium leprae FATTY-ACID-CoA LIGASE FADD26 (FATTY-ACID-COA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Luciferin 4-monooxygenase   550 aa 533 aa 22.7 %
Schistosoma mansoni GTP-binding protein alpha subunit gna GNAS complex locus 394 aa 450 aa 28.7 %
Leishmania braziliensis acetyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 596 aa 21.1 %
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD9 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 480 aa 22.5 %
Candida albicans similar to S. cerevisiae FAT1 (YBR041W) fatty acid transporter and very long-chain fatty acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 496 aa 24.2 %
Onchocerca volvulus Luciferin 4-monooxygenase   550 aa 502 aa 24.9 %
Trichomonas vaginalis antibiotic synthetase, putative Luciferin 4-monooxygenase   550 aa 577 aa 22.2 %
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein Luciferin 4-monooxygenase   550 aa 476 aa 22.5 %
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase FadD15 Luciferin 4-monooxygenase   550 aa 482 aa 24.3 %
Trichomonas vaginalis antibiotic synthetase, putative Luciferin 4-monooxygenase   550 aa 581 aa 21.2 %
Onchocerca volvulus Lysine-specific histone demethylase 1A homolog Luciferin 4-monooxygenase   550 aa 550 aa 22.5 %
Entamoeba histolytica acyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 446 aa 22.0 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 535 aa 21.7 %
Mycobacterium tuberculosis Probable acyl-CoA ligase FadD31 (acyl-CoA synthetase) (acyl-CoA synthase) Luciferin 4-monooxygenase   550 aa 592 aa 20.4 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 522 aa 19.9 %
Mycobacterium ulcerans fatty-acid-CoA ligase FadD9 Luciferin 4-monooxygenase   550 aa 463 aa 21.8 %
Babesia bovis long-chain acyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 445 aa 21.8 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 538 aa 21.8 %
Trichomonas vaginalis long-chain-fatty-acid CoA ligase, putative Luciferin 4-monooxygenase   550 aa 490 aa 23.3 %
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD22 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 493 aa 20.7 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 530 aa 23.8 %
Loa Loa (eye worm) AMP-binding enzyme family protein Luciferin 4-monooxygenase   550 aa 489 aa 23.3 %
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase Luciferin 4-monooxygenase   550 aa 536 aa 24.4 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 539 aa 19.1 %
Mycobacterium ulcerans fatty-acid-CoA ligase FadD11 Luciferin 4-monooxygenase   550 aa 498 aa 23.5 %
Dictyostelium discoideum AMP-dependent synthetase and ligase domain-containing protein Luciferin 4-monooxygenase   550 aa 517 aa 24.8 %
Trypanosoma cruzi fatty acyl CoA synthetase 2, putative Luciferin 4-monooxygenase   550 aa 495 aa 22.6 %
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD29 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 617 aa 22.2 %
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtF Luciferin 4-monooxygenase   550 aa 558 aa 20.1 %
Trichomonas vaginalis AMP dependent ligase, putative Luciferin 4-monooxygenase   550 aa 445 aa 26.1 %
Leishmania infantum long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 500 aa 23.4 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 541 aa 21.4 %
Echinococcus multilocularis long chain fatty acid coenzyme A ligase 5 Luciferin 4-monooxygenase   550 aa 458 aa 25.5 %
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD29 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 529 aa 22.3 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 507 aa 20.9 %
Onchocerca volvulus Matrilysin homolog Luciferin 4-monooxygenase   550 aa 466 aa 24.2 %
Schistosoma japonicum ko:K01897 long-chain fatty-acid-CoA ligase [EC6.2.1.3], putative Luciferin 4-monooxygenase   550 aa 541 aa 22.4 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 526 aa 22.4 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 542 aa 18.3 %
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase Luciferin 4-monooxygenase   550 aa 509 aa 21.8 %
Toxoplasma gondii intraflagellar transport protein 172, putative glycoprotein hormones, alpha polypeptide 116 aa 94 aa 26.6 %
Toxoplasma gondii propionate-CoA ligase Luciferin 4-monooxygenase   550 aa 550 aa 21.1 %
Trichomonas vaginalis AMP dependent CoA ligase, putative Luciferin 4-monooxygenase   550 aa 527 aa 25.0 %
Dictyostelium discoideum fatty acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 462 aa 23.8 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 476 aa 23.5 %
Trichomonas vaginalis long-chain-fatty-acid CoA ligase, putative Luciferin 4-monooxygenase   550 aa 466 aa 21.7 %
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 Luciferin 4-monooxygenase   550 aa 493 aa 22.1 %
Candida albicans similar to S. cerevisiae FAA4 (YMR246W) long-chain fatty acid--CoA synthetase Luciferin 4-monooxygenase   550 aa 478 aa 23.4 %
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD28 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 484 aa 20.5 %
Leishmania braziliensis acetyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 603 aa 22.6 %
Brugia malayi AMP-binding enzyme family protein Luciferin 4-monooxygenase   550 aa 497 aa 24.7 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 582 aa 22.3 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 541 aa 21.4 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 593 aa 22.1 %
Leishmania major long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 482 aa 23.2 %
Schistosoma japonicum ko:K01897 long-chain fatty-acid-CoA ligase [EC6.2.1.3], putative Luciferin 4-monooxygenase   550 aa 466 aa 27.3 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 538 aa 21.8 %
Candida albicans similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 543 aa 24.5 %
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative Luciferin 4-monooxygenase   550 aa 494 aa 23.9 %
Echinococcus granulosus long chain fatty acid coenzyme A ligase 1 Luciferin 4-monooxygenase   550 aa 452 aa 26.1 %
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD32 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 442 aa 23.5 %
Trichomonas vaginalis AMP dependent CoA ligase, putative Luciferin 4-monooxygenase   550 aa 524 aa 24.0 %
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative Luciferin 4-monooxygenase   550 aa 476 aa 20.8 %
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase FadD15 Luciferin 4-monooxygenase   550 aa 484 aa 26.0 %
Mycobacterium ulcerans peptide synthetase Nrp (peptide synthase) Luciferin 4-monooxygenase   550 aa 535 aa 23.2 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 554 aa 24.4 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 539 aa 19.1 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 463 aa 23.5 %
Dictyostelium discoideum AMP-dependent synthetase and ligase domain-containing protein Luciferin 4-monooxygenase   550 aa 545 aa 24.9 %
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 505 aa 28.1 %
Cryptosporidium parvum putative long chain fatty acyl CoA synthetase having a signal peptide Luciferin 4-monooxygenase   550 aa 472 aa 24.8 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 558 aa 20.4 %
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase, FadD11 Luciferin 4-monooxygenase   550 aa 492 aa 24.6 %
Echinococcus granulosus long chain fatty acid transport protein 4 Luciferin 4-monooxygenase   550 aa 476 aa 22.3 %
Schistosoma japonicum ko:K08745 solute carrier family 27 (fatty acid transporter), member 1, putative Luciferin 4-monooxygenase   550 aa 501 aa 24.6 %
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD28 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 504 aa 22.6 %
Leishmania mexicana long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 483 aa 23.8 %
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative Luciferin 4-monooxygenase   550 aa 480 aa 21.5 %
Echinococcus multilocularis long chain fatty acid transport protein 4 Luciferin 4-monooxygenase   550 aa 476 aa 22.3 %
Cryptosporidium hominis acetyl-CoenzymeA synthetase (acetate--coa ligase) (acyl-activating enzyme) Luciferin 4-monooxygenase   550 aa 549 aa 22.6 %
Dictyostelium discoideum acetyl-CoA ligase Luciferin 4-monooxygenase   550 aa 549 aa 22.2 %
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD21 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 586 aa 24.4 %
Candida albicans similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 539 aa 22.1 %
Babesia bovis fatty acyl-CoA synthetase family protein Luciferin 4-monooxygenase   550 aa 461 aa 23.4 %
Onchocerca volvulus Luciferin 4-monooxygenase   550 aa 487 aa 23.8 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 478 aa 21.1 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 522 aa 19.9 %
Candida albicans similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 543 aa 24.5 %
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD23 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 542 aa 23.8 %
Mycobacterium leprae Probable fatty-acid-CoA ligase FadD9 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 461 aa 22.3 %
Cryptosporidium parvum acetyl-coenzyme A synthetase Luciferin 4-monooxygenase   550 aa 545 aa 22.8 %
Trypanosoma cruzi fatty acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 482 aa 24.7 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 576 aa 19.8 %
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtE Luciferin 4-monooxygenase   550 aa 502 aa 22.5 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 554 aa 22.9 %
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD26 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 560 aa 21.4 %
Neospora caninum Short-chain dehydrogenase/reductase SDR, related Luciferin 4-monooxygenase   550 aa 518 aa 19.1 %
Dictyostelium discoideum fatty acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 501 aa 24.4 %
Trichomonas vaginalis AMP dependent CoA ligase, putative Luciferin 4-monooxygenase   550 aa 492 aa 23.6 %
Mycobacterium leprae PROBABLE FATTY-ACID--CoA LIGASE FADD21 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Luciferin 4-monooxygenase   550 aa 565 aa 22.8 %
Brugia malayi AMP-binding enzyme family protein Luciferin 4-monooxygenase   550 aa 544 aa 21.5 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 541 aa 21.6 %
Theileria parva long-chain fatty acid CoA ligase, putative Luciferin 4-monooxygenase   550 aa 507 aa 23.5 %
Mycobacterium ulcerans non-ribosomal peptide synthetase Luciferin 4-monooxygenase   550 aa 541 aa 22.4 %
Schistosoma mansoni FAA1 Long-chain-fatty-acid--CoA ligase 1 Luciferin 4-monooxygenase   550 aa 494 aa 26.3 %
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD24 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 526 aa 21.9 %
Cryptosporidium hominis acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 460 aa 26.1 %
Loa Loa (eye worm) pigment dispersing factor receptor c glucagon-like peptide 1 receptor 463 aa 388 aa 25.8 %
Trypanosoma congolense fatty acyl CoA synthetase 2, putative Luciferin 4-monooxygenase   550 aa 500 aa 22.4 %
Leishmania braziliensis long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 496 aa 22.8 %
Trypanosoma cruzi fatty acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 480 aa 25.2 %
Leishmania braziliensis long-chain-fatty-acid-CoA ligase, putative Luciferin 4-monooxygenase   550 aa 504 aa 25.6 %
Echinococcus multilocularis long chain fatty acid coenzyme A ligase 1 Luciferin 4-monooxygenase   550 aa 459 aa 27.0 %
Trypanosoma brucei gambiense fatty acyl CoA synthetase 4, putative Luciferin 4-monooxygenase   550 aa 497 aa 23.7 %
Candida albicans similar to S. cerevisiae FAT1 (YBR041W) fatty acid transporter and very long-chain fatty acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 496 aa 24.2 %
Cryptosporidium parvum acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 460 aa 25.7 %
Trypanosoma brucei gambiense fatty acyl CoA synthetase 3 Luciferin 4-monooxygenase   550 aa 491 aa 23.6 %
Echinococcus granulosus long chain fatty acid coenzyme A ligase 5 Luciferin 4-monooxygenase   550 aa 458 aa 25.8 %
Leishmania mexicana acetyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 559 aa 20.6 %
Leishmania donovani long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 500 aa 23.4 %
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD32 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase). Also shown to have acyl-ACP ligase activity. Luciferin 4-monooxygenase   550 aa 487 aa 22.4 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 601 aa 22.5 %
Echinococcus multilocularis long chain fatty acid coenzyme A ligase 1 Luciferin 4-monooxygenase   550 aa 443 aa 26.4 %
Toxoplasma gondii type I fatty acid synthase, putative Luciferin 4-monooxygenase   550 aa 514 aa 19.8 %
Candida albicans similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 539 aa 22.1 %
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD25 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 475 aa 21.1 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 541 aa 21.6 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 535 aa 22.6 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 542 aa 22.1 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.0291 1 1
Loa Loa (eye worm) hypothetical protein 0.0244 0.8268 0.8268
Loa Loa (eye worm) animal heme peroxidase 0.0244 0.8268 0.8268
Echinococcus multilocularis nicotinic acetylcholine receptor subunit type 0.0134 0.4186 0.3668
Loa Loa (eye worm) hypothetical protein 0.0134 0.4186 0.4186
Loa Loa (eye worm) hypothetical protein 0.0157 0.5021 0.5021
Loa Loa (eye worm) hypothetical protein 0.0134 0.4186 0.4186
Brugia malayi hypothetical protein 0.0134 0.4186 0.4025
Echinococcus granulosus Cys loop ligand gated ion channel subunit 0.0291 1 1
Mycobacterium ulcerans acyl-CoA synthetase 0.0029 0.0268 1
Loa Loa (eye worm) hypothetical protein 0.0157 0.5021 0.5021
Schistosoma mansoni nAChR subunit 0.0291 1 1
Schistosoma mansoni nAChR subunit 0.0291 1 1
Brugia malayi Acetylcholine receptor protein, alpha-like chain 1 precursor 0.0134 0.4186 0.4025
Onchocerca volvulus 0.0291 1 1
Loa Loa (eye worm) neuronal acetylcholine receptor protein 0.0134 0.4186 0.4186
Loa Loa (eye worm) hypothetical protein 0.0134 0.4186 0.4186
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0029 0.0268 0.5
Loa Loa (eye worm) blistered cuticle protein 3 0.0244 0.8268 0.8268
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0291 1 1
Echinococcus granulosus glycine receptor subunit alpha 1 0.0291 1 1
Loa Loa (eye worm) hypothetical protein 0.0157 0.5021 0.5021
Schistosoma mansoni nAChR subunit (ShAR1-beta2-like) 0.0291 1 1
Loa Loa (eye worm) hypothetical protein 0.0134 0.4186 0.4186
Loa Loa (eye worm) hypothetical protein 0.0157 0.5021 0.5021
Loa Loa (eye worm) hypothetical protein 0.0134 0.4186 0.4186
Loa Loa (eye worm) hypothetical protein 0.0291 1 1
Schistosoma mansoni nAChR subunit (ShAR1-beta-like) 0.0291 1 1
Brugia malayi latrophilin 2 splice variant baaae 0.0041 0.0732 0.0477
Onchocerca volvulus 0.0291 1 1
Loa Loa (eye worm) acetylcholine receptor protein 0.0134 0.4186 0.4186
Brugia malayi Hypothetical glycine receptor like protein T20B12.9 in chromosome III 0.0291 1 1
Loa Loa (eye worm) hypothetical protein 0.0291 1 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.1255 0.0563
Loa Loa (eye worm) hypothetical protein 0.0134 0.4186 0.4186
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0291 1 1
Loa Loa (eye worm) hypothetical protein 0.0134 0.4186 0.4186
Brugia malayi hypothetical protein 0.0134 0.4186 0.4025
Brugia malayi hypothetical protein 0.0134 0.4186 0.4025
Onchocerca volvulus 0.0134 0.4186 0.4025
Echinococcus multilocularis nicotinic acetylcholine receptor subunit alpha 8 0.0291 1 1
Brugia malayi acetylcholine receptor alpha subunit precursor, putative 0.0291 1 1
Loa Loa (eye worm) hypothetical protein 0.0291 1 1
Loa Loa (eye worm) hypothetical protein 0.0244 0.8268 0.8268
Loa Loa (eye worm) hypothetical protein 0.0134 0.4186 0.4186
Loa Loa (eye worm) hypothetical protein 0.0029 0.0268 0.0268
Onchocerca volvulus 0.0291 1 1
Onchocerca volvulus 0.0157 0.5021 0.4884
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0134 0.4186 0.4025
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0291 1 1
Onchocerca volvulus 0.0244 0.8268 0.822
Loa Loa (eye worm) hypothetical protein 0.0134 0.4186 0.4186
Loa Loa (eye worm) hypothetical protein 0.0291 1 1
Loa Loa (eye worm) ACC-1 protein 0.0291 1 1
Loa Loa (eye worm) hypothetical protein 0.0134 0.4186 0.4186
Schistosoma mansoni nAChR subunit 0.0291 1 1
Brugia malayi Animal haem peroxidase family protein 0.0244 0.8268 0.822
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0157 0.5021 0.4628
Loa Loa (eye worm) hypothetical protein 0.0291 1 1
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0291 1 1
Echinococcus granulosus nicotinic acetylcholine receptor beta 1 subunit 0.0291 1 1
Loa Loa (eye worm) LGC-31 protein 0.0291 1 1
Loa Loa (eye worm) hypothetical protein 0.006 0.1438 0.1438
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0029 0.0268 1
Loa Loa (eye worm) hypothetical protein 0.0244 0.8268 0.8268
Brugia malayi hypothetical protein 0.0043 0.0817 0.0564
Loa Loa (eye worm) ACC-1 protein 0.0291 1 1
Entamoeba histolytica hypothetical protein 0.0043 0.0817 0.1155
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0291 1 1
Onchocerca volvulus Peroxidasin homolog 0.0244 0.8268 0.822
Schistosoma mansoni nAChR subunit 0.0291 1 1
Brugia malayi Cation transporter family protein 0.0291 1 1
Brugia malayi nicotinic acetylcholine receptor alpha subunit, putative 0.0291 1 1
Loa Loa (eye worm) hypothetical protein 0.0291 1 1
Loa Loa (eye worm) hypothetical protein 0.0157 0.5021 0.5021
Onchocerca volvulus Dual oxidase homolog 0.0244 0.8268 0.822
Onchocerca volvulus Peroxidase homolog 0.0244 0.8268 0.822
Echinococcus multilocularis peroxidasin 0.0244 0.8268 0.8113
Loa Loa (eye worm) hypothetical protein 0.0244 0.8268 0.8268
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0029 0.0268 1
Loa Loa (eye worm) hypothetical protein 0.0134 0.4186 0.4186
Entamoeba histolytica hypothetical protein 0.0157 0.5021 1
Brugia malayi Animal haem peroxidase family protein 0.0244 0.8268 0.822
Onchocerca volvulus 0.0134 0.4186 0.4025
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0029 0.0268 0.5
Onchocerca volvulus Peroxidasin homolog 0.0244 0.8268 0.822
Onchocerca volvulus 0.0182 0.5971 0.586
Brugia malayi Blistered cuticle protein 3 0.0244 0.8268 0.822
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0291 1 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.1255 0.0563
Schistosoma mansoni nAChR subunit 0.0291 1 1
Brugia malayi acetylcholine receptor protein, alpha-like chain, putative 0.0291 1 1
Loa Loa (eye worm) excitatory GABA receptor EXP-1A 0.0291 1 1
Brugia malayi Cation transporter family protein 0.0291 1 1
Schistosoma mansoni transcription factor LCR-F1 0.0043 0.0817 0.0092
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0029 0.0268 1
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0134 0.4186 0.4025
Loa Loa (eye worm) hypothetical protein 0.0244 0.8268 0.8268
Loa Loa (eye worm) acetylcholine receptor alpha subunit 0.0291 1 1
Echinococcus granulosus gamma aminobutyric acid receptor subunit 0.0134 0.4186 0.3668
Echinococcus granulosus peroxidasin 0.0244 0.8268 0.8113
Schistosoma mansoni acetylcholine receptor-related 0.0134 0.4186 0.3726
Echinococcus granulosus acetylcholine receptor subunit beta 1 0.0291 1 1
Leishmania major 4-coumarate:coa ligase-like protein 0.0029 0.0268 0.5
Schistosoma mansoni nAChR subunit 0.0134 0.4186 0.3726
Echinococcus granulosus glycine receptor subunit alpha 1 0.0291 1 1
Loa Loa (eye worm) hypothetical protein 0.0244 0.8268 0.8268
Onchocerca volvulus Chorion peroxidase homolog 0.0244 0.8268 0.822
Brugia malayi hypothetical protein 0.0244 0.8268 0.822
Schistosoma mansoni neurotransmitter gated ion channel 0.0157 0.5021 0.4628
Plasmodium vivax acyl-CoA synthetase, putative 0.0021 0 0.5
Brugia malayi Animal haem peroxidase family protein 0.0244 0.8268 0.822
Brugia malayi Animal haem peroxidase family protein 0.0244 0.8268 0.822
Schistosoma mansoni peroxidasin 0.0244 0.8268 0.8131
Loa Loa (eye worm) hypothetical protein 0.0291 1 1
Loa Loa (eye worm) hypothetical protein 0.0134 0.4186 0.4186
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0029 0.0268 1
Echinococcus multilocularis glycine receptor subunit beta 0.0291 1 1
Leishmania major 4-coumarate:coa ligase-like protein 0.0029 0.0268 0.5
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0021 0 0.5
Loa Loa (eye worm) hypothetical protein 0.0291 1 1
Loa Loa (eye worm) hypothetical protein 0.0244 0.8268 0.8268
Mycobacterium ulcerans acyl-CoA synthetase 0.0029 0.0268 1
Brugia malayi Peroxidasin 0.0244 0.8268 0.822
Schistosoma mansoni neurotransmitter gated ion channel 0.0134 0.4186 0.3726
Echinococcus granulosus nAChR subunit 0.0291 1 1
Echinococcus granulosus glycine receptor subunit beta 0.0291 1 1
Onchocerca volvulus 0.0244 0.8268 0.822
Loa Loa (eye worm) GABA receptor subunit 0.0157 0.5021 0.5021
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0291 1 1
Brugia malayi Neuronal acetylcholine receptor protein, alpha-2 chain precursor 0.0134 0.4186 0.4025
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.1255 0.0476
Mycobacterium ulcerans acyl-CoA synthetase 0.0029 0.0268 1
Brugia malayi glutamate-gated chloride channel alpha3A subunit, putative 0.0157 0.5021 0.4884
Loa Loa (eye worm) glutamate-gated chloride channel alpha3A subunit 0.0291 1 1
Echinococcus granulosus glycine receptor subunit alpha 1 0.0291 1 1
Echinococcus multilocularis nAChR subunit 0.0157 0.5021 0.4578
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0029 0.0268 1
Loa Loa (eye worm) pigment dispersing factor receptor c 0.006 0.1438 0.1438
Schistosoma mansoni neurotransmitter gated ion channel 0.0134 0.4186 0.3726
Loa Loa (eye worm) animal heme peroxidase 0.0244 0.8268 0.8268
Schistosoma mansoni acetylcholine receptor subunit beta 0.0134 0.4186 0.3726
Loa Loa (eye worm) ligand-Gated ion Channel family member 0.0291 1 1
Loa Loa (eye worm) hypothetical protein 0.0182 0.5971 0.5971
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0029 0.0268 1
Loa Loa (eye worm) hypothetical protein 0.0291 1 1
Onchocerca volvulus 0.0134 0.4186 0.4025
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0055 0.1255 0.1013
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0291 1 1
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0291 1 1
Brugia malayi gamma-aminobutyric-acid receptor beta subunit precursor 0.0291 1 1
Loa Loa (eye worm) hypothetical protein 0.0291 1 1
Echinococcus multilocularis nicotinic acetylcholine receptor alpha subunit 0.0291 1 1
Echinococcus multilocularis nicotinic acetylcholine receptor a11 subunit 0.0291 1 1
Entamoeba histolytica hypothetical protein 0.0043 0.0817 0.1155
Loa Loa (eye worm) hypothetical protein 0.0291 1 1
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.006 0.1438 0.1202
Loa Loa (eye worm) hypothetical protein 0.0157 0.5021 0.5021
Loa Loa (eye worm) hypothetical protein 0.0291 1 1
Brugia malayi Calcitonin receptor-like protein seb-1 0.006 0.1438 0.1202
Loa Loa (eye worm) hypothetical protein 0.0291 1 1
Echinococcus multilocularis Cys loop ligand gated ion channel subunit 0.0134 0.4186 0.3668
Onchocerca volvulus 0.0291 1 1
Onchocerca volvulus 0.0244 0.8268 0.822
Echinococcus multilocularis nAChR subunit 0.0291 1 1
Loa Loa (eye worm) hypothetical protein 0.0244 0.8268 0.8268
Brugia malayi hypothetical protein 0.0182 0.5971 0.586
Loa Loa (eye worm) hypothetical protein 0.0134 0.4186 0.4186
Schistosoma mansoni nAChR subunit 0.0291 1 1
Brugia malayi Hypothetical glycine receptor like protein T20B12.9 in chromosome III 0.0157 0.5021 0.4884
Brugia malayi Cation transporter family protein 0.0291 1 1
Echinococcus multilocularis Cys loop ligand gated ion channel subunit 0.0291 1 1
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.1255 0.0476
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0291 1 1
Echinococcus granulosus Cys loop ligand gated ion channel subunit 0.0134 0.4186 0.3668
Loa Loa (eye worm) hypothetical protein 0.0291 1 1
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0291 1 1
Echinococcus multilocularis gamma aminobutyric acid receptor subunit 0.0134 0.4186 0.3668
Leishmania major 4-coumarate:coa ligase-like protein 0.0029 0.0268 0.5
Echinococcus multilocularis acetylcholine receptor subunit beta 1 0.0291 1 1
Echinococcus multilocularis glycine receptor subunit beta 0.0291 1 1
Entamoeba histolytica hypothetical protein 0.0043 0.0817 0.1155
Loa Loa (eye worm) hypothetical protein 0.0029 0.0268 0.0268
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0291 1 1
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0157 0.5021 0.4884
Brugia malayi Animal haem peroxidase family protein 0.0244 0.8268 0.822
Echinococcus multilocularis nicotinic acetylcholine receptor beta 1 subunit 0.0291 1 1
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.1255 0.0476
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.1255 0.0563
Echinococcus multilocularis neuronal acetylcholine receptor subunit alpha 4 0.0291 1 1
Brugia malayi nicotinic acetylcholine receptor beta-1 chain precursor 0.0291 1 1
Echinococcus granulosus nicotinic acetylcholine receptor subunit alpha 8 0.0291 1 1
Onchocerca volvulus Peroxidase homolog 0.0244 0.8268 0.822
Onchocerca volvulus 0.0157 0.5021 0.4884
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0157 0.5021 0.4884
Loa Loa (eye worm) hypothetical protein 0.0134 0.4186 0.4186
Echinococcus granulosus nicotinic acetylcholine receptor subunit type 0.0291 1 1
Schistosoma mansoni nAChR subunit 0.0134 0.4186 0.3726
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0134 0.4186 0.4025
Echinococcus granulosus nAChR subunit 0.0157 0.5021 0.4578
Loa Loa (eye worm) nicotinic acetylcholine receptor non-alpha subunit 0.0291 1 1
Brugia malayi acetylcholine receptor, alpha-type subunit unc-38 precursor 0.0291 1 1
Loa Loa (eye worm) hypothetical protein 0.0244 0.8268 0.8268
Loa Loa (eye worm) hypothetical protein 0.0041 0.0732 0.0732
Echinococcus granulosus nicotinic acetylcholine receptor a11 subunit 0.0291 1 1
Loa Loa (eye worm) nicotinic acetylcholine receptor alpha subunit 0.0291 1 1
Plasmodium falciparum acyl-CoA synthetase 0.0021 0 0.5
Loa Loa (eye worm) animal heme peroxidase 0.0244 0.8268 0.8268
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0291 1 1
Loa Loa (eye worm) hypothetical protein 0.0029 0.0268 0.0268
Echinococcus granulosus nicotinic acetylcholine receptor alpha subunit 0.0291 1 1
Schistosoma mansoni nAChR subunit (ShAR1-alpha-like) 0.0291 1 1
Echinococcus granulosus glycine receptor subunit beta 0.0291 1 1
Schistosoma mansoni nAChR subunit 0.0291 1 1
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0055 0.1255 0.1255
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0291 1 1
Mycobacterium ulcerans hypothetical protein 0.0029 0.0268 1
Echinococcus granulosus neuronal acetylcholine receptor subunit alpha 4 0.0291 1 1
Loa Loa (eye worm) hypothetical protein 0.0157 0.5021 0.5021
Loa Loa (eye worm) hypothetical protein 0.0244 0.8268 0.8268
Loa Loa (eye worm) hypothetical protein 0.0291 1 1
Loa Loa (eye worm) hypothetical protein 0.0244 0.8268 0.8268
Schistosoma mansoni hypothetical protein 0.0043 0.0817 0.0092
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0291 1 1
Schistosoma mansoni nicotinic acetylcholine receptor alpha 0.0157 0.5021 0.4628
Onchocerca volvulus Putative nachr subunit 0.0291 1 1
Loa Loa (eye worm) animal heme peroxidase 0.0244 0.8268 0.8268
Loa Loa (eye worm) hypothetical protein 0.0291 1 1
Brugia malayi glutamate-gated chloride channel alpha3A subunit, putative 0.0134 0.4186 0.4025
Brugia malayi hypothetical protein 0.0134 0.4186 0.4025
Onchocerca volvulus 0.0291 1 1
Brugia malayi hypothetical protein 0.0134 0.4186 0.4025
Schistosoma mansoni peroxidasin 0.0244 0.8268 0.8131
Loa Loa (eye worm) hypothetical protein 0.0244 0.8268 0.8268
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.1255 0.0476
Loa Loa (eye worm) hypothetical protein 0.0157 0.5021 0.5021
Loa Loa (eye worm) hypothetical protein 0.0157 0.5021 0.5021
Entamoeba histolytica hypothetical protein 0.0043 0.0817 0.1155
Loa Loa (eye worm) hypothetical protein 0.0244 0.8268 0.8268
Loa Loa (eye worm) hypothetical protein 0.0291 1 1
Loa Loa (eye worm) glutamate-gated chloride channel alpha3A subunit 0.0134 0.4186 0.4186
Loa Loa (eye worm) hypothetical protein 0.0244 0.8268 0.8268
Loa Loa (eye worm) hypothetical protein 0.0291 1 1
Loa Loa (eye worm) hypothetical protein 0.0134 0.4186 0.4186
Onchocerca volvulus 0.0291 1 1

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 4.1475 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 10.691 uM PUBCHEM_BIOASSAY: qHTS profiling assay for firefly luciferase inhibitor/activator using purified enzyme and Km concentrations of substrates (counterscreen for miR-21 project). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2288, AID2289, AID2598, AID411] ChEMBL. No reference
Potency (functional) 11.2202 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Vif-A3F Interactions: qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 11.2202 uM PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 14.1254 uM PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 15.8489 uM PubChem BioAssay. qHTS for Activators of Integrin-Mediated Alleviation for Muscular Dystrophy. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 18.3564 uM PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648] ChEMBL. No reference
Potency (functional) = 39.8107 um PUBCHEM_BIOASSAY: qHTS Assay for the Inhibitors of L3MBTL1. (Class of assay: confirmatory) [Related pubchem assays: 485292 (Probe Development Summary for Inhibitors of L3MBTL1)] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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