TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 723.543 | Formula: C31H28F7NO11
H donors: 5 H acceptors: 8 LogP: 4.03 Rotable bonds: 9
Rule of 5 violations (Lipinski): 2
SMILES: COc1cccc2c1C(=O)c1c(C2=O)c(O)c2c(c1O)[C@@H](OC1OC(C)C(C(C1)NC(=O)C(C(C(F)(F)F)(F)F)(F)F)O)C[C@](C2)(O)C(=O)C
InChi: 1S/C31H28F7NO11/c1-10-22(41)14(39-27(46)29(32,33)30(34,35)31(36,37)38)7-17(49-10)50-16-9-28(47,11(2)40)8-13-19(16)26(45)21-20(24(13)43)23(42)12-5-4-6-15(48-3)18(12)25(21)44/h4-6,10,14,16-17,22,41,43,45,47H,7-9H2,1-3H3,(H,39,46)/t10?,14?,16-,17?,22?,28-/m0/s1
InChiKey: RQBKPRMOKCVJDU-WBKQXHNWSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.005	0.0233
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0015	0.0056	0.0093
Brugia malayi	Eukaryotic-type carbonic anhydrase family protein	0.0152	0.3249	0.5988
Brugia malayi	Nuclear hormone receptor family member nhr-1	0.0021	0.0188	0.0336
Loa Loa (eye worm)	hypothetical protein	0.0057	0.1023	0.1879
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0016	0.0073	0.0341
Loa Loa (eye worm)	hypothetical protein	0.0051	0.0904	0.1658
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.005	0.0233
Trypanosoma brucei	myo-inositol/proton symporter (MIT)	0.0015	0.005	0.0136
Brugia malayi	Eukaryotic-type carbonic anhydrase family protein	0.0057	0.1023	0.1879
Schistosoma mansoni	hypothetical protein	0.0131	0.2747	0.7651
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0016	0.0073	0.0124
Plasmodium falciparum	calcium-dependent protein kinase 1	0.0032	0.0452	0.0404
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-49	0.0021	0.0188	0.0336
Echinococcus granulosus	calcium:calmodulin dependent protein kinase type	0.0032	0.0451	0.0513
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0028	0.0357	0.1675
Trypanosoma cruzi	phosphatidylinositol 3-related kinase, putative	0.0016	0.0073	0.0207
Loa Loa (eye worm)	hypothetical protein	0.0015	0.005	0.0081
Toxoplasma gondii	prolyl-tRNA synthetase (ProRS)	0.0036	0.0557	0.0779
Echinococcus multilocularis	thyroid hormone receptor alpha	0.0151	0.3226	0.4061
Leishmania major	tyrosyl-DNA phosphodiesterase 1	0.0069	0.1302	0.3997
Loa Loa (eye worm)	eukaryotic-type carbonic anhydrase	0.0057	0.1023	0.1879
Trypanosoma brucei	phosphatidylinositol 4-kinase, putative	0.0047	0.0794	0.2432
Brugia malayi	Major Facilitator Superfamily protein	0.0015	0.005	0.0081
Trypanosoma brucei	Phosphatidylinositol 3-kinase tor1	0.0047	0.0794	0.2432
Echinococcus granulosus	hepatocyte nuclear factor 4 alpha	0.0021	0.0188	0.0176
Loa Loa (eye worm)	hypothetical protein	0.0015	0.005	0.0081
Loa Loa (eye worm)	hypothetical protein	0.0049	0.0846	0.1552
Echinococcus multilocularis	GPCR, family 2	0.0015	0.0069	0.0024
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0047	0.0794	0.3724
Entamoeba histolytica	FKBP-rapamycin associated protein (FRAP), putative	0.0047	0.0794	0.5176
Echinococcus granulosus	FKBP12 rapamycin complex associated protein	0.0047	0.0794	0.0952
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0016	0.0073	0.0341
Trypanosoma cruzi	phosphatidylinositol 3-related kinase, putative	0.0016	0.0073	0.0207
Echinococcus granulosus	solute carrier family 2 facilitated glucose	0.0104	0.2133	0.2664
Loa Loa (eye worm)	hypothetical protein	0.0246	0.5422	1
Mycobacterium ulcerans	lysyl-tRNA synthetase	0.0023	0.025	1
Brugia malayi	lysyl-tRNA synthetase	0.0023	0.025	0.0451
Echinococcus granulosus	calcium:calmodulin dependent protein kinase type	0.0032	0.0451	0.0513
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.005	0.0233
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0021	0.0188	0.0336
Trypanosoma cruzi	target of rapamycin kinase 3	0.0037	0.0573	0.175
Leishmania major	target of rapamycin (TOR) kinase 2, putative	0.0047	0.0794	0.2432
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0025	0.0294	0.1378
Trichomonas vaginalis	conserved hypothetical protein	0.0015	0.005	0.0233
Trichomonas vaginalis	lysyl-tRNA synthetase, putative	0.002	0.0183	0.0859
Schistosoma mansoni	hypothetical protein	0.0015	0.0069	0.0054
Trichomonas vaginalis	sugar transporter, putative	0.0032	0.0461	0.2159
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0021	0.0188	0.0336
Echinococcus granulosus	netrin receptor unc 5	0.0015	0.0056	0.0008
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-14	0.0021	0.0188	0.0336
Brugia malayi	Nuclear hormone receptor family member nhr-41	0.0021	0.0188	0.0336
Loa Loa (eye worm)	carbonic anhydrase 3	0.0152	0.3249	0.5988
Brugia malayi	steroid hormone receptor	0.0021	0.0188	0.0336
Trypanosoma cruzi	carbonic anhydrase-like protein, putative	0.0152	0.3249	1
Schistosoma mansoni	nuclear hormone receptor	0.0021	0.0188	0.0392
Trichomonas vaginalis	PIKK family atypical protein kinase	0.004	0.0636	0.298
Trypanosoma brucei	THT1 - hexose transporter, putative	0.0032	0.0461	0.1403
Loa Loa (eye worm)	sugar transporter	0.0104	0.2133	0.3929
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0021	0.0188	0.0336
Brugia malayi	Sugar transporter family protein	0.0015	0.005	0.0081
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0049	0.0846	0.1552
Echinococcus granulosus	tyrosyl DNA phosphodiesterase 1	0.0069	0.1302	0.1601
Schistosoma mansoni	hypothetical protein	0.0015	0.0056	0.0017
Loa Loa (eye worm)	CAMK/CAMK2 protein kinase	0.0032	0.0451	0.0823
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.005	0.0233
Mycobacterium ulcerans	sugar transporter	0.0015	0.005	0.1803
Leishmania major	lysyl-tRNA synthetase, putative	0.0023	0.025	0.0753
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.005	0.0233
Trypanosoma brucei	bifunctional aminoacyl-tRNA synthetase, putative	0.0036	0.0557	0.1699
Brugia malayi	Latrophilin receptor protein 2	0.0015	0.0069	0.0116
Schistosoma mansoni	hypothetical protein	0.0166	0.3576	1
Echinococcus multilocularis	carbonic anhydrase	0.0057	0.1023	0.1245
Leishmania major	glucose transporter, lmgt3	0.0032	0.0461	0.1403
Trichomonas vaginalis	PIKK family atypical protein kinase	0.003	0.0414	0.1938
Entamoeba histolytica	hypothetical protein	0.0037	0.0578	0.3118
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0015	0.0069	0.0024
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0015	0.0069	0.0116
Schistosoma mansoni	hypothetical protein	0.0033	0.0486	0.1239
Schistosoma mansoni	protein kinase	0.0032	0.0451	0.1139
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0188	0.0336
Schistosoma mansoni	carbonic anhydrase-related	0.0057	0.1023	0.2761
Echinococcus multilocularis	transcription factor Dp 1	0.004	0.0631	0.0743
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0025	0.0295	0.1383
Echinococcus granulosus	calcium dependent protein kinase	0.003	0.0405	0.0455
Trypanosoma brucei	glucose transporter, putative	0.0032	0.0461	0.1403
Echinococcus granulosus	geminin	0.0166	0.3576	0.4507
Plasmodium falciparum	carbonic anhydrase	0.0057	0.1023	0.0978
Schistosoma mansoni	carbonic anhydrase-related	0.0057	0.1023	0.2761
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.005	0.0233
Schistosoma mansoni	Tr4/Tr2 (homologue)	0.0021	0.0188	0.0392
Wolbachia endosymbiont of Brugia malayi	major facilitator superfamily permease	0.0015	0.005	0.5
Brugia malayi	Nuclear hormone receptor family member nhr-14	0.0021	0.0188	0.0336
Trypanosoma cruzi	hexose transporter	0.0032	0.0461	0.1403
Toxoplasma gondii	calcium-dependent protein kinase CDPK2A	0.0032	0.0452	0.0617
Schistosoma mansoni	glucose transport protein	0.0104	0.2133	0.591
Schistosoma mansoni	retinoic acid receptor RXR	0.0021	0.0188	0.0392
Loa Loa (eye worm)	major facilitator superfamily transporter	0.0015	0.005	0.0081
Echinococcus granulosus	nuclear factor of activated T cells 5	0.0076	0.1486	0.1836
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.005	0.0233
Echinococcus granulosus	solute carrier family 2 facilitated glucose	0.0104	0.2133	0.2664
Trypanosoma brucei	sugar transporter, putative	0.0015	0.005	0.0136
Echinococcus multilocularis	tumor protein p63	0.0351	0.7872	1
Echinococcus multilocularis	survival motor neuron protein 1	0.0246	0.5422	0.6867
Trypanosoma brucei	phosphatidylinositol 3-related kinase, putative	0.0016	0.0073	0.0207
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0016	0.0073	0.0341
Mycobacterium leprae	Possible lysyl-tRNA synthetase 2 LysX	0.0023	0.025	0.3046
Trypanosoma cruzi	hexose transporter, putative	0.0032	0.0461	0.1403
Schistosoma mansoni	glucose transport protein	0.0104	0.2133	0.591
Plasmodium falciparum	lysine--tRNA ligase	0.0023	0.025	0.0201
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.005	0.0233
Echinococcus granulosus	COUP TF:Svp nuclear hormone receptor	0.0021	0.0188	0.0176
Echinococcus granulosus	survival motor neuron protein 1	0.0246	0.5422	0.6867
Trypanosoma cruzi	carbonic anhydrase-like protein, putative	0.0152	0.3249	1
Schistosoma mansoni	tyrosyl-DNA phosphodiesterase	0.0069	0.1302	0.3552
Echinococcus multilocularis	solute carrier family 2 facilitated glucose	0.0104	0.2133	0.2664
Echinococcus granulosus	FTZ F1 alpha	0.0021	0.0188	0.0176
Entamoeba histolytica	protein kinase, putative	0.0032	0.0451	0.1913
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.005	0.0233
Echinococcus granulosus	retinoic acid receptor rxr beta a	0.0021	0.0188	0.0176
Loa Loa (eye worm)	hypothetical protein	0.0023	0.025	0.0451
Echinococcus multilocularis	Nuclear hormone receptor family member nhr 41	0.0021	0.0188	0.0176
Entamoeba histolytica	prolyl-tRNA synthetase, putative	0.0031	0.0436	0.177
Trypanosoma cruzi	sugar transporter, putative	0.0015	0.005	0.0136
Echinococcus granulosus	Mitotic checkpoint protein PRCC C terminal	0.0131	0.2747	0.3449
Leishmania major	prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative	0.0036	0.0557	0.1699
Brugia malayi	major facilitator superfamily protein	0.0015	0.005	0.0081
Giardia lamblia	Lysyl-tRNA synthetase	0.0023	0.025	0.2689
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.005	0.0233
Loa Loa (eye worm)	phosphatidylinositol 3	0.0047	0.0794	0.1456
Echinococcus multilocularis	geminin	0.0166	0.3576	0.4507
Trypanosoma brucei	phosphatidylinositol 3-kinase, putative	0.0016	0.0073	0.0207
Echinococcus multilocularis	tyrosyl DNA phosphodiesterase 1	0.0069	0.1302	0.1601
Brugia malayi	Carbonic anhydrase like protein 2 precursor	0.0057	0.1023	0.1879
Leishmania major	carbonic anhydrase-like protein	0.0152	0.3249	1
Echinococcus granulosus	carbonic anhydrase	0.0057	0.1023	0.1245
Trypanosoma brucei	glucose transporter, putative	0.0032	0.0461	0.1403
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0028	0.0357	0.1675
Echinococcus multilocularis	ecdysone induced protein 78C	0.0021	0.0188	0.0176
Echinococcus multilocularis	Ankyrin	0.0015	0.0059	0.0012
Brugia malayi	ecdysteroid receptor	0.0021	0.0188	0.0336
Giardia lamblia	GTOR	0.0047	0.0794	1
Brugia malayi	Cam kinase protein 1	0.0032	0.0451	0.0823
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0035	0.0516	0.242
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0035	0.0516	0.242
Brugia malayi	bifunctional aminoacyl-tRNA synthetase	0.0031	0.0436	0.0795
Brugia malayi	Calcium/calmodulin-dependent protein kinase type II alpha chain	0.0032	0.0451	0.0823
Trichomonas vaginalis	sugar transport protein, putative	0.0015	0.005	0.0233
Loa Loa (eye worm)	hypothetical protein	0.0015	0.005	0.0081
Leishmania major	hypothetical protein, conserved	0.0015	0.005	0.0136
Plasmodium vivax	calcium-dependent protein kinase 3, putative	0.0032	0.0452	0.0404
Brugia malayi	Bifunctional aminoacyl-tRNA synthetase	0.0031	0.0436	0.0795
Brugia malayi	nuclear hormone receptor	0.0021	0.0188	0.0336
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.005	0.0233
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.005	0.0233
Entamoeba histolytica	phosphatidylinositol3-kinaseTor2, putative	0.0047	0.0794	0.5176
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0035	0.0516	0.242
Brugia malayi	Steroid receptor seven-up type 2	0.0021	0.0188	0.0336
Schistosoma mansoni	nuclear receptor 2DBD-gamma	0.0021	0.0188	0.0392
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.005	0.0233
Loa Loa (eye worm)	tyrosyl-DNA phosphodiesterase	0.0069	0.1302	0.2394
Plasmodium vivax	lysine--tRNA ligase, putative	0.0023	0.025	0.0201
Plasmodium falciparum	hexose transporter	0.0104	0.2133	0.2094
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0451	0.0823
Echinococcus granulosus	lysyl tRNA synthetase	0.0023	0.025	0.0256
Brugia malayi	Nuclear hormone receptor family member nhr-40	0.0021	0.0188	0.0336
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.005	0.0233
Trypanosoma brucei	target of rapamycin kinase 3, putative	0.0037	0.0573	0.175
Schistosoma mansoni	RAR-like nuclear receptor	0.0021	0.0188	0.0392
Schistosoma mansoni	glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs)	0.0031	0.0436	0.1096
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0047	0.0794	0.1456
Trypanosoma cruzi	lysyl-tRNA synthetase, putative	0.0023	0.025	0.0753
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0021	0.0188	0.0336
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.005	0.0233
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0015	0.0069	0.0024
Brugia malayi	Major Facilitator Superfamily protein	0.0015	0.005	0.0081
Schistosoma mansoni	hypothetical protein	0.0037	0.0578	0.1498
Entamoeba histolytica	hypothetical protein	0.0037	0.0578	0.3118
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0056	0.0093
Trichomonas vaginalis	conserved hypothetical protein	0.0015	0.005	0.0233
Trichomonas vaginalis	glucose transporter, putative	0.0032	0.0461	0.2159
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0049	0.0846	0.1552
Schistosoma mansoni	hypothetical protein	0.0015	0.0069	0.0054
Loa Loa (eye worm)	hypothetical protein	0.0015	0.005	0.0081
Leishmania major	target of rapamycin (TOR) kinase 1, putative	0.0047	0.0794	0.2432
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0188	0.0336
Schistosoma mansoni	ataxia telangiectasia mutated (atm)-related	0.0047	0.0794	0.2112
Trypanosoma cruzi	prolyl-tRNA synthetase, putative	0.0036	0.0557	0.1699
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.005	0.0233
Echinococcus multilocularis	carbonic anhydrase II	0.0152	0.3249	0.409
Trypanosoma cruzi	hexose transporter, putative	0.0015	0.005	0.0136
Echinococcus granulosus	solute carrier family 2 facilitated glucose	0.0104	0.2133	0.2664
Echinococcus granulosus	General substrate transporter	0.009	0.1793	0.2228
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0047	0.0794	0.3724
Echinococcus granulosus	FTZ F1 nuclear receptor protein	0.0021	0.0188	0.0176
Plasmodium vivax	hexose transporter	0.0104	0.2133	0.2094
Plasmodium falciparum	calcium-dependent protein kinase 2	0.0032	0.0452	0.0404
Trichomonas vaginalis	conserved hypothetical protein	0.0015	0.005	0.0233
Plasmodium falciparum	calcium-dependent protein kinase 5	0.0032	0.0452	0.0404
Schistosoma mansoni	hypothetical protein	0.0057	0.1023	0.2761
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0031	0.0437	0.2048
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0037	0.0572	0.2682
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0035	0.0516	0.242
Mycobacterium ulcerans	lysyl-tRNA synthetase	0.0023	0.025	1
Trypanosoma brucei	glucose transporter, putative	0.0032	0.0461	0.1403
Trichomonas vaginalis	conserved hypothetical protein	0.0015	0.005	0.0233
Schistosoma mansoni	nuclear hormone receptor nor-1/nor-2	0.0021	0.0188	0.0392
Trypanosoma brucei	glucose transporter, putative	0.0032	0.0461	0.1403
Loa Loa (eye worm)	bifunctional aminoacyl-tRNA synthetase	0.0013	0.0007	0.0003
Onchocerca volvulus		0.0021	0.0188	0.1617
Trichomonas vaginalis	CAMK family protein kinase	0.0032	0.0451	0.2115
Entamoeba histolytica	hypothetical protein	0.0037	0.0578	0.3118
Trichomonas vaginalis	lysyl-tRNA synthetase, putative	0.0023	0.025	0.1171
Echinococcus multilocularis	lysyl tRNA synthetase	0.0023	0.025	0.0256
Trypanosoma brucei	lysyl-tRNA synthetase, putative	0.0023	0.025	0.0753
Echinococcus multilocularis	General substrate transporter	0.009	0.1793	0.2228
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0059	0.0098
Echinococcus multilocularis	nuclear factor of activated T cells 5	0.0076	0.1486	0.1836
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0028	0.0351	0.1645
Trichomonas vaginalis	sugar transporter, putative	0.0032	0.0461	0.2159
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-31	0.0021	0.0188	0.0336
Echinococcus multilocularis	hepatocyte nuclear factor 4 alpha	0.0021	0.0188	0.0176
Plasmodium falciparum	calcium-dependent protein kinase 3	0.0032	0.0452	0.0404
Brugia malayi	nuclear receptor NHR-88	0.0021	0.0188	0.0336
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.005	0.0233
Loa Loa (eye worm)	hypothetical protein	0.0015	0.005	0.0081
Echinococcus multilocularis	solute carrier family 2, facilitated glucose	0.0104	0.2133	0.2664
Schistosoma mansoni	glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs)	0.0031	0.0436	0.1096
Trypanosoma brucei	phosphatidylinositol 3-kinase tor, putative	0.0022	0.0222	0.0668
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0037	0.0572	0.2682
Loa Loa (eye worm)	immunoglobulin I-set domain-containing protein	0.0015	0.0056	0.0093
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0021	0.0188	0.0176
Loa Loa (eye worm)	sugar transporter	0.0015	0.005	0.0081
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0188	0.0336
Schistosoma mansoni	photoreceptor-specific nuclear receptor related	0.0021	0.0188	0.0392
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0037	0.0572	0.2682
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0021	0.0188	0.0176
Echinococcus granulosus	transcription factor Dp 1	0.004	0.0631	0.0743
Plasmodium vivax	calcium-dependent protein kinase 4, putative	0.0032	0.0452	0.0404
Brugia malayi	Eukaryotic-type carbonic anhydrase family protein	0.0057	0.1023	0.1879
Trypanosoma cruzi	tyrosyl-DNA Phosphodiesterase (Tdp1), putative	0.0069	0.1302	0.3997
Leishmania major	glucose transporter, lmgt1	0.0032	0.0461	0.1403
Trypanosoma cruzi	hexose transporter, putative	0.0032	0.0461	0.1403
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0037	0.0578	0.0675
Echinococcus multilocularis	solute carrier family 2 facilitated glucose	0.0104	0.2133	0.2664
Schistosoma mansoni	lysyl-tRNA synthetase	0.0023	0.025	0.0568
Schistosoma mansoni	coup transcription factor	0.0021	0.0188	0.0392
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.005	0.0233
Echinococcus multilocularis	netrin receptor unc 5	0.0015	0.0056	0.0008
Echinococcus multilocularis	FTZ F1 alpha	0.0021	0.0188	0.0176
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0025	0.0294	0.1378
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.005	0.0233
Echinococcus multilocularis	calcium:calmodulin dependent protein kinase type	0.0032	0.0451	0.0513
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0015	0.0069	0.0024
Trypanosoma brucei	calcium/calmodulin-dependent protein kinase, putative	0.0032	0.0451	0.1374
Trypanosoma brucei	glucose transporter, putative	0.0032	0.0461	0.1403
Mycobacterium ulcerans	sugar-transport integral membrane protein SugI	0.0015	0.005	0.1803
Brugia malayi	Iron-sulfur cluster assembly accessory protein	0.005	0.0874	0.1603
Schistosoma mansoni	ankyrin 23/unc44	0.0015	0.0056	0.0017
Echinococcus multilocularis	FTZ F1 nuclear receptor protein	0.0021	0.0188	0.0176
Echinococcus multilocularis	Mitotic checkpoint protein PRCC, C terminal	0.0131	0.2747	0.3449
Brugia malayi	Nuclear hormone receptor family member nhr-3	0.0021	0.0188	0.0336
Leishmania major	target of rapamycin kinase (TOR) kinase 3	0.0037	0.0573	0.175
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0037	0.0572	0.2682
Trichomonas vaginalis	glucose transporter, putative	0.0015	0.005	0.0233
Echinococcus granulosus	death domain containing protein	0.0015	0.0056	0.0008
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0021	0.0188	0.0336
Trypanosoma brucei	tyrosyl-DNA Phosphodiesterase (Tdp1), putative	0.0069	0.1302	0.3997
Brugia malayi	Sugar transporter family protein	0.0104	0.2133	0.3929
Toxoplasma gondii	facilitative glucose transporter GT1	0.0104	0.2133	0.3201
Schistosoma mansoni	transcription factor LCR-F1	0.0037	0.0578	0.1498
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-40	0.0021	0.0188	0.0336
Loa Loa (eye worm)	eukaryotic-type carbonic anhydrase	0.0152	0.3249	0.5988
Brugia malayi	Nuclear hormone receptor family member nhr-31	0.0021	0.0188	0.0336
Onchocerca volvulus	Netrin receptor homolog	0.0015	0.0056	0.0071
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0035	0.0516	0.242
Echinococcus multilocularis	phosphatidylinositol 3 and 4 kinase	0.0016	0.0073	0.003
Mycobacterium tuberculosis	Lysyl-tRNA synthetase 1 LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase)	0.002	0.0168	1
Onchocerca volvulus	Steroid hormone receptor family member cnr14 homolog	0.0021	0.0188	0.1617
Brugia malayi	major facilitator superfamily protein	0.0015	0.005	0.0081
Onchocerca volvulus	Protein ultraspiracle homolog	0.0021	0.0188	0.1617
Brugia malayi	Death domain containing protein	0.0015	0.0056	0.0093
Echinococcus granulosus	carbonic anhydrase	0.0057	0.1023	0.1245
Trichomonas vaginalis	prolyl-tRNA synthetase, putative	0.0031	0.0436	0.2044
Schistosoma mansoni	lysyl-tRNA synthetase	0.0023	0.025	0.0568
Plasmodium vivax	proline--tRNA ligase, putative	0.0036	0.0557	0.051
Trichomonas vaginalis	glucose transporter, putative	0.0032	0.0461	0.2159
Schistosoma mansoni	hypothetical protein	0.0015	0.0069	0.0054
Toxoplasma gondii	hypothetical protein	0.0057	0.1023	0.1495
Plasmodium falciparum	protein kinase 7	0.0295	0.6559	0.6542
Mycobacterium tuberculosis	Lysyl-tRNA synthetase 2 LysX	0.002	0.0168	1
Trypanosoma brucei	glucose transporter, putative	0.0032	0.0461	0.1403
Schistosoma mansoni	glucose transport protein	0.0104	0.2133	0.591
Schistosoma mansoni	hypothetical protein	0.0104	0.2133	0.591
Echinococcus multilocularis	carbonic anhydrase	0.0057	0.1023	0.1245
Echinococcus granulosus	Nuclear hormone receptor family member nhr 41	0.0021	0.0188	0.0176
Leishmania major	phosphatidylinositol 3-related kinase, putative	0.0016	0.0073	0.0207
Echinococcus multilocularis	COUP TF:Svp nuclear hormone receptor	0.0021	0.0188	0.0176
Echinococcus multilocularis	calcium:calmodulin dependent protein kinase type	0.0032	0.0451	0.0513
Brugia malayi	Sugar transporter family protein	0.0015	0.005	0.0081
Trypanosoma cruzi	hexose transporter, putative	0.0018	0.012	0.0352
Echinococcus granulosus	carbonic anhydrase	0.0057	0.1023	0.1245
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.005	0.0233
Trichomonas vaginalis	conserved hypothetical protein	0.0104	0.2133	1
Loa Loa (eye worm)	hypothetical protein	0.0015	0.005	0.0081
Trichomonas vaginalis	conserved hypothetical protein	0.0015	0.005	0.0233
Leishmania major	glucose transporter, lmgt2	0.0032	0.0461	0.1403
Toxoplasma gondii	target of rapamycin (TOR), putative	0.0035	0.0516	0.0717
Chlamydia trachomatis	lysine--tRNA ligase	0.0023	0.025	0.5
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.005	0.0233
Brugia malayi	Protein kinase domain containing protein	0.0017	0.0102	0.0178
Brugia malayi	Carbonic anhydrase like protein 2 precursor	0.0057	0.1023	0.1879
Echinococcus granulosus	tumor protein p63	0.0351	0.7872	1
Loa Loa (eye worm)	phosphatidylinositol 3	0.0016	0.0073	0.0124
Loa Loa (eye worm)	hypothetical protein	0.0015	0.005	0.0081
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0049	0.0846	0.1552
Schistosoma mansoni	thyroid hormone receptor	0.0151	0.3226	0.9009
Brugia malayi	Eukaryotic-type carbonic anhydrase family protein	0.0057	0.1023	0.1879
Toxoplasma gondii	protein kinase, putative	0.0295	0.6559	1
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-41	0.0021	0.0188	0.0336
Onchocerca volvulus	Bile acid receptor homolog	0.0021	0.0188	0.1617
Trichomonas vaginalis	conserved hypothetical protein	0.0032	0.0461	0.2159
Echinococcus granulosus	carbonic anhydrase II	0.0152	0.3249	0.409
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0486	0.0888
Trypanosoma brucei	glucose transporter, putative	0.0032	0.0461	0.1403
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0021	0.0188	0.0176
Echinococcus multilocularis	calcium:calmodulin dependent protein kinase type	0.0032	0.0451	0.0513
Toxoplasma gondii	cell-cycle-associated protein kinase MAPK, putative	0.0168	0.3627	0.5495
Brugia malayi	latrophilin 2 splice variant baaae	0.0033	0.0486	0.0888
Loa Loa (eye worm)	hypothetical protein	0.0015	0.005	0.0081
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0037	0.0572	0.2682
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.005	0.0233
Leishmania major	myo-inositol/proton symporter (MIT)	0.0015	0.005	0.0136
Brugia malayi	hypothetical protein	0.0037	0.0578	0.1057
Plasmodium vivax	calcium-dependent protein kinase, putative	0.0032	0.0452	0.0404
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0188	0.0336
Toxoplasma gondii	calcium-dependent protein kinase CDPK2B	0.0032	0.0452	0.0617
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0069	0.0116
Schistosoma mansoni	carbonic anhydrase II (carbonate dehydratase II)	0.0152	0.3249	0.9073
Loa Loa (eye worm)	hypothetical protein	0.0015	0.005	0.0081
Loa Loa (eye worm)	hypothetical protein	0.0015	0.005	0.0081
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0035	0.0516	0.242
Brugia malayi	Uncoordinated protein 44	0.0015	0.0056	0.0093
Mycobacterium leprae	Probable prolyl tRNA synthetase ProS	0.0031	0.0436	1
Echinococcus granulosus	ankyrin repeat and death domain containing protein	0.0015	0.0056	0.0008
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0021	0.0188	0.0176
Trypanosoma cruzi	Phosphatidylinositol 3-kinase tor2	0.0047	0.0794	0.2432
Onchocerca volvulus		0.0051	0.0904	1
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0188	0.0336
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0015	0.0069	0.0024
Echinococcus granulosus	calcium:calmodulin dependent protein kinase type	0.0032	0.0451	0.0513
Schistosoma mansoni	protein kinase	0.0032	0.0451	0.1139
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0436	0.0795
Loa Loa (eye worm)	hypothetical protein	0.0015	0.005	0.0081
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.005	0.0233
Schistosoma mansoni	carbonic anhydrase	0.0057	0.1023	0.2761
Brugia malayi	hypothetical protein	0.0015	0.005	0.0081
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0037	0.0578	0.0675
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.005	0.0233
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-1	0.0021	0.0188	0.0336
Leishmania major	protein kinase, putative	0.0032	0.0451	0.1374
Trypanosoma cruzi	tyrosyl-DNA Phosphodiesterase (Tdp1), putative	0.0069	0.1302	0.3997
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0035	0.0516	0.242
Schistosoma mansoni	serine/threonine protein kinase	0.0032	0.0451	0.1139
Schistosoma mansoni	retinoblastoma-binding protein 4 (rbbp4)	0.0015	0.0059	0.0026
Echinococcus multilocularis	solute carrier family 2 facilitated glucose	0.0104	0.2133	0.2664
Loa Loa (eye worm)	nuclear Hormone Receptor family member	0.0021	0.0188	0.0336
Echinococcus granulosus	solute carrier family 2 facilitated glucose	0.0104	0.2133	0.2664
Trichomonas vaginalis	sugar transporter, putative	0.0032	0.0461	0.2159
Echinococcus granulosus	phosphatidylinositol 3 and 4 kinase	0.0016	0.0073	0.003
Loa Loa (eye worm)	hypothetical protein	0.0015	0.005	0.0081
Trypanosoma cruzi	glucose transporter, putative	0.0015	0.005	0.0136
Loa Loa (eye worm)	major facilitator superfamily transporter	0.0015	0.005	0.0081
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.005	0.0233
Trypanosoma cruzi	prolyl-tRNA synthetase, putative	0.0036	0.0557	0.1699
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0016	0.0073	0.0341
Echinococcus multilocularis	calcium dependent protein kinase	0.003	0.0405	0.0455
Echinococcus multilocularis	FKBP12 rapamycin complex associated protein	0.0047	0.0794	0.0952
Trypanosoma brucei	THT1 - hexose transporter, putative	0.0032	0.0461	0.1403
Brugia malayi	Nuclear hormone receptor family member nhr-49	0.0021	0.0188	0.0336
Leishmania major	glucose transporter/membrane transporter D2, putative	0.0032	0.0461	0.1403
Onchocerca volvulus		0.005	0.0874	0.9653
Brugia malayi	Major Facilitator Superfamily protein	0.0015	0.005	0.0081
Loa Loa (eye worm)	steroid hormone receptor	0.0021	0.0188	0.0336
Trypanosoma brucei	carbonic anhydrase-like protein	0.0152	0.3249	1
Schistosoma mansoni	protein kinase	0.0032	0.0451	0.1139
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0025	0.0295	0.1383
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0021	0.0188	0.0392
Trypanosoma brucei	glucose transporter 2A	0.0032	0.0461	0.1403
Schistosoma mansoni	carbonic anhydrase-related	0.0057	0.1023	0.2761
Trichomonas vaginalis	conserved hypothetical protein	0.0032	0.0461	0.2159
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.005	0.0233
Plasmodium falciparum	proline--tRNA ligase	0.0036	0.0557	0.051
Trichomonas vaginalis	myo-inositol transporter, putative	0.0015	0.005	0.0233
Schistosoma mansoni	carbonic anhydrase II (carbonate dehydratase II)	0.0152	0.3249	0.9073
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.005	0.0233
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.005	0.0233
Trypanosoma brucei	THT1 - hexose transporter, putative	0.0032	0.0461	0.1403
Schistosoma mansoni	survival motor neuron protein	0.005	0.0874	0.2338
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.005	0.0233
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0188	0.0336
Echinococcus granulosus	calcium:calmodulin dependent protein kinase type 1	0.0032	0.0451	0.0513
Loa Loa (eye worm)	hypothetical protein	0.0057	0.1023	0.1879
Schistosoma mansoni	cellular tumor antigen P53	0.0051	0.0904	0.2422
Trypanosoma cruzi	Phosphatidylinositol 3-kinase tor1	0.0047	0.0794	0.2432
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0025	0.0294	0.1378
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.005	0.0233
Echinococcus multilocularis	ankyrin repeat and death domain containing protein	0.0015	0.0056	0.0008
Brugia malayi	Tyrosyl-DNA phosphodiesterase family protein	0.0069	0.1302	0.2394
Leishmania major	phosphatidylinositol 3-kinase, putative	0.0016	0.0073	0.0207
Echinococcus multilocularis	carbonic anhydrase	0.0057	0.1023	0.1245
Brugia malayi	photoreceptor-specific nuclear receptor	0.0021	0.0188	0.0336
Schistosoma mansoni	hypothetical protein	0.005	0.0874	0.2338
Schistosoma mansoni	FTZ-F1 nuclear receptor-like protein	0.0021	0.0188	0.0392
Loa Loa (eye worm)	hypothetical protein	0.0057	0.1023	0.1879
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0188	0.0336
Trypanosoma brucei	glucose transporter 1E	0.0032	0.0461	0.1403
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0028	0.0357	0.1675
Schistosoma mansoni	steroid hormone receptor ad4bp	0.0021	0.0188	0.0392
Schistosoma mansoni	hypothetical protein	0.0166	0.3576	1
Brugia malayi	Nuclear hormone receptor-like 1	0.0021	0.0188	0.0336
Echinococcus multilocularis	calcium:calmodulin dependent protein kinase type	0.0032	0.0451	0.0513
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.005	0.0233
Trypanosoma cruzi	hexose transporter, putative	0.0032	0.0461	0.1403
Loa Loa (eye worm)	calcium/calmodulin-dependent protein kinase ID	0.0032	0.0451	0.0823
Plasmodium falciparum	calcium-dependent protein kinase 4	0.0032	0.0452	0.0404
Echinococcus granulosus	ecdysone induced protein 78C	0.0021	0.0188	0.0176
Loa Loa (eye worm)	hypothetical protein	0.0015	0.005	0.0081
Trypanosoma brucei	FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative	0.0019	0.016	0.0475
Echinococcus granulosus	glutamyl tRNA synthetase cytoplasmic	0.0031	0.0436	0.0494
Echinococcus granulosus	GPCR family 2	0.0015	0.0069	0.0024
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.005	0.0233
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0436	0.0795
Brugia malayi	hypothetical protein	0.0015	0.005	0.0081
Leishmania major	prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative	0.0036	0.0557	0.1699
Brugia malayi	hypothetical protein	0.0015	0.005	0.0081
Brugia malayi	hypothetical protein	0.0246	0.5422	1
Echinococcus multilocularis	glutamyl tRNA synthetase cytoplasmic	0.0031	0.0436	0.0494
Schistosoma mansoni	netrin receptor unc5	0.0015	0.0056	0.0017
Loa Loa (eye worm)	hypothetical protein	0.0015	0.005	0.0081
Trypanosoma brucei	glucose transporter, putative	0.0032	0.0461	0.1403
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0021	0.0188	0.0336
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0025	0.0295	0.1383
Toxoplasma gondii	lysine-tRNA ligase	0.0023	0.025	0.0308
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0015	0.0069	0.0116
Schistosoma mansoni	phosphatidylinositol 3-and 4-kinase	0.0016	0.0073	0.0066
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0025	0.0295	0.1383
Plasmodium vivax	mitogen-activated protein kinase 2, putative	0.0168	0.3627	0.3595
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0016	0.0073	0.0341
Mycobacterium ulcerans	integral membrane transport protein	0.0015	0.005	0.1803
Entamoeba histolytica	hypothetical protein	0.0037	0.0578	0.3118
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0047	0.0794	0.3724
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.005	0.0233
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.005	0.0233
Mycobacterium ulcerans	fusion protein of transposase for IS2606 and sialic acid-transport integral membrane protein NanT	0.0015	0.005	0.1803
Plasmodium vivax	CDK-related protein kinase 6, putative	0.0442	1	1
Entamoeba histolytica	protein kinase, putative	0.0032	0.0451	0.1913
Giardia lamblia	Prolyl-tRNA synthetase	0.0031	0.0436	0.5189
Schistosoma mansoni	hypothetical protein	0.0015	0.0069	0.0054
Schistosoma mansoni	thyroid hormone receptor	0.0151	0.3226	0.9009
Plasmodium vivax	calcium-dependent protein kinase 1, putative	0.0032	0.0452	0.0404
Loa Loa (eye worm)	hypothetical protein	0.0025	0.03	0.0543
Plasmodium falciparum	mitogen-activated protein kinase 2	0.0168	0.3627	0.3595
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.005	0.0233
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0028	0.0351	0.1645
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0188	0.0336
Entamoeba histolytica	tyrosyl-DNA phosphodiesterase, putative	0.0069	0.1302	1
Brugia malayi	Putative carbonic anhydrase 5 precursor	0.0152	0.3249	0.5988
Echinococcus granulosus	Ankyrin	0.0015	0.0059	0.0012
Toxoplasma gondii	calcium-dependent protein kinase CDPK3	0.0032	0.0452	0.0617
Loa Loa (eye worm)	hypothetical protein	0.0015	0.005	0.0081

Activities

Activity type	Activity value	Assay description	Source	Reference
ID50 (functional)	> 1.35 uM	Inhibitory activity against CCRF-CEM(human leukemic lymphoblastic) cells in culture.	ChEMBL.	7057426
ID50 (functional)	> 1.35 uM	Inhibitory activity against CCRF-CEM(human leukemic lymphoblastic) cells in culture.	ChEMBL.	7057426
ILS (functional)	= 45 %	In vivo growth inhibitory activity was measured against murine P388 leukemia cells as Percent increase in life span at the dose of 40.0 mg/kg/day	ChEMBL.	7057426
ILS (functional)	= 45 %	In vivo growth inhibitory activity was measured against murine P388 leukemia cells as Percent increase in life span at the dose of 40.0 mg/kg/day	ChEMBL.	7057426

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL300994

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 81790