Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | aurora kinase A | 0.0304 | 0.0857 | 0.0872 |
Loa Loa (eye worm) | hypothetical protein | 0.016 | 0.0388 | 0.1007 |
Mycobacterium tuberculosis | Probable cytochrome P450 123 Cyp123 | 0.0125 | 0.0273 | 0.5 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0197 | 0.0508 | 0.1434 |
Schistosoma mansoni | Neurotrimin precursor (hNT) | 0.0131 | 0.0295 | 0.0295 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0942 | 0.2928 | 1 |
Trypanosoma cruzi | polo-like protein kinase, putative | 0.0942 | 0.2928 | 1 |
Echinococcus granulosus | defective proboscis extension response | 0.0131 | 0.0295 | 0.0032 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0197 | 0.0508 | 0.1434 |
Brugia malayi | Immunoglobulin I-set domain containing protein | 0.0131 | 0.0295 | 0.008 |
Giardia lamblia | Kinase, PLK | 0.0942 | 0.2928 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0131 | 0.0295 | 0.0678 |
Trypanosoma brucei | polo-like protein kinase | 0.0942 | 0.2928 | 1 |
Echinococcus multilocularis | Immunoglobulin | 0.0131 | 0.0295 | 0.0032 |
Brugia malayi | serine/threonine kinase 12 | 0.0304 | 0.0857 | 0.2199 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0478 | 0.1421 | 0.4664 |
Brugia malayi | Cytochrome P450 family protein | 0.0478 | 0.1421 | 0.4322 |
Mycobacterium tuberculosis | Possible cytochrome P450 135B1 Cyp135B1 | 0.0125 | 0.0273 | 0.5 |
Leishmania major | cytochrome p450-like protein | 0.0197 | 0.0508 | 0.0885 |
Echinococcus granulosus | neurotracting:lsamp:neurotrimin:obcam | 0.0147 | 0.0347 | 0.011 |
Schistosoma mansoni | defective proboscis extension response (dpr)-related | 0.0131 | 0.0295 | 0.0295 |
Schistosoma mansoni | nephrin | 0.0144 | 0.0335 | 0.0335 |
Entamoeba histolytica | serine/threonine protein kinase, putative | 0.0942 | 0.2928 | 1 |
Brugia malayi | hypothetical protein | 0.0131 | 0.0295 | 0.008 |
Mycobacterium leprae | Conserved hypothetical protein | 0.0125 | 0.0273 | 0.5 |
Echinococcus granulosus | roundabout 2 | 0.016 | 0.0388 | 0.0171 |
Trypanosoma brucei | cytochrome P450, putative | 0.0197 | 0.0508 | 0.0885 |
Mycobacterium tuberculosis | Cytochrome P450 121 Cyp121 | 0.0125 | 0.0273 | 0.5 |
Mycobacterium tuberculosis | Probable cytochrome P450 125 Cyp125 | 0.0125 | 0.0273 | 0.5 |
Toxoplasma gondii | aurora kinase | 0.0304 | 0.0857 | 1 |
Schistosoma mansoni | vesicular amine transporter | 0.0131 | 0.0295 | 0.0295 |
Loa Loa (eye worm) | hypothetical protein | 0.0131 | 0.0295 | 0.0678 |
Trypanosoma cruzi | aurora B kinase, putative | 0.0304 | 0.0857 | 0.2199 |
Loa Loa (eye worm) | AUR protein kinase | 0.0304 | 0.0857 | 0.2669 |
Loa Loa (eye worm) | hypothetical protein | 0.0131 | 0.0295 | 0.0678 |
Echinococcus granulosus | twitchin | 0.0152 | 0.0363 | 0.0134 |
Mycobacterium tuberculosis | Probable cytochrome P450 139 Cyp139 | 0.0125 | 0.0273 | 0.5 |
Echinococcus granulosus | neuroglian | 0.0144 | 0.0335 | 0.0093 |
Onchocerca volvulus | Serine\/threonine kinase homolog | 0.0942 | 0.2928 | 1 |
Brugia malayi | Cytochrome P450 family protein | 0.0197 | 0.0508 | 0.0885 |
Loa Loa (eye worm) | AUR protein kinase | 0.0304 | 0.0857 | 0.2669 |
Echinococcus multilocularis | roundabout 2 | 0.016 | 0.0388 | 0.0171 |
Echinococcus multilocularis | Serine:threonine protein kinase PLK4 | 0.2186 | 0.6968 | 1 |
Loa Loa (eye worm) | TK/KIN16 protein kinase | 0.0889 | 0.2757 | 0.9394 |
Mycobacterium tuberculosis | Possible cytochrome P450 126 Cyp126 | 0.0125 | 0.0273 | 0.5 |
Plasmodium falciparum | serine/threonine protein kinase, putative | 0.0304 | 0.0857 | 0.5 |
Trypanosoma cruzi | cytochrome P450, putative | 0.0197 | 0.0508 | 0.0885 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0942 | 0.2928 | 1 |
Mycobacterium tuberculosis | Possible cytochrome P450 135A1 Cyp135A1 | 0.0125 | 0.0273 | 0.5 |
Brugia malayi | Fibronectin type III domain containing protein | 0.0131 | 0.0295 | 0.008 |
Loa Loa (eye worm) | CYP4Cod1 | 0.0197 | 0.0508 | 0.1434 |
Loa Loa (eye worm) | hypothetical protein | 0.0131 | 0.0295 | 0.0678 |
Loa Loa (eye worm) | PLK/PLK1 protein kinase | 0.0942 | 0.2928 | 1 |
Plasmodium vivax | serine/threonine protein kinase 6, putative | 0.0304 | 0.0857 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0125 | 0.0273 | 0.0273 |
Brugia malayi | serine/threonine-protein kinase plk-2 | 0.0942 | 0.2928 | 1 |
Leishmania major | protein kinase, putative | 0.0304 | 0.0857 | 0.2199 |
Mycobacterium tuberculosis | Probable cytochrome P450 143 Cyp143 | 0.0125 | 0.0273 | 0.5 |
Echinococcus granulosus | Immunoglobulin | 0.0131 | 0.0295 | 0.0032 |
Mycobacterium tuberculosis | Probable cytochrome P450 monooxygenase 142 Cyp142 | 0.0125 | 0.0273 | 0.5 |
Mycobacterium tuberculosis | Probable cytochrome P450 132 Cyp132 | 0.0125 | 0.0273 | 0.5 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0942 | 0.2928 | 0.2928 |
Trypanosoma cruzi | polo-like protein kinase, putative | 0.0942 | 0.2928 | 1 |
Echinococcus granulosus | serine:threonine protein kinase PLK1 | 0.0942 | 0.2928 | 0.3965 |
Leishmania major | protein kinase, putative,polo-like protein kinase, putative | 0.0942 | 0.2928 | 1 |
Echinococcus multilocularis | basement membrane specific heparan sulfate | 0.0131 | 0.0295 | 0.0032 |
Mycobacterium tuberculosis | Probable cytochrome P450 137 Cyp137 | 0.0125 | 0.0273 | 0.5 |
Brugia malayi | Cytochrome P450 family protein | 0.0197 | 0.0508 | 0.0885 |
Mycobacterium tuberculosis | Probable cytochrome P450 144 Cyp144 | 0.0125 | 0.0273 | 0.5 |
Mycobacterium tuberculosis | Probable cytochrome P450 128 Cyp128 | 0.0125 | 0.0273 | 0.5 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0942 | 0.2928 | 1 |
Brugia malayi | serine/threonine protein kinase 6 | 0.0304 | 0.0857 | 0.2199 |
Mycobacterium tuberculosis | Probable cytochrome P450 138 Cyp138 | 0.0125 | 0.0273 | 0.5 |
Mycobacterium tuberculosis | Probable cytochrome P450 136 Cyp136 | 0.0125 | 0.0273 | 0.5 |
Mycobacterium ulcerans | cytochrome P450 185A4 Cyp185A4 | 0.0197 | 0.0508 | 1 |
Schistosoma mansoni | cytochrome P450 | 0.0125 | 0.0273 | 0.0273 |
Echinococcus multilocularis | Immunoglobulin | 0.0131 | 0.0295 | 0.0032 |
Mycobacterium tuberculosis | Probable cytochrome P450 124 Cyp124 | 0.0125 | 0.0273 | 0.5 |
Echinococcus multilocularis | neuroglian | 0.0144 | 0.0335 | 0.0093 |
Loa Loa (eye worm) | hypothetical protein | 0.0131 | 0.0295 | 0.0678 |
Schistosoma mansoni | cell adhesion molecule | 0.0147 | 0.0347 | 0.0347 |
Echinococcus multilocularis | serine:threonine protein kinase PLK1 | 0.0942 | 0.2928 | 0.3965 |
Brugia malayi | serine/threonine-protein kinase 6 | 0.0304 | 0.0857 | 0.2199 |
Mycobacterium tuberculosis | Probable cytochrome P450 140 Cyp140 | 0.0125 | 0.0273 | 0.5 |
Onchocerca volvulus | Tyrosine kinase homolog | 0.0755 | 0.2319 | 0.1156 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0942 | 0.2928 | 1 |
Trypanosoma cruzi | cytochrome P450, putative | 0.0197 | 0.0508 | 0.0885 |
Schistosoma mansoni | protein kinase | 0.0304 | 0.0857 | 0.0857 |
Mycobacterium tuberculosis | Cytochrome P450 51 Cyp51 (CYPL1) (P450-L1A1) (sterol 14-alpha demethylase) (lanosterol 14-alpha demethylase) (P450-14DM) | 0.0125 | 0.0273 | 0.5 |
Brugia malayi | Immunoglobulin I-set domain containing protein | 0.0889 | 0.2757 | 0.9355 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0942 | 0.2928 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0147 | 0.0347 | 0.0862 |
Trypanosoma brucei | aurora B kinase | 0.0304 | 0.0857 | 0.2199 |
Loa Loa (eye worm) | cytochrome P450 | 0.0125 | 0.0273 | 0.0603 |
Echinococcus granulosus | aurora kinase A | 0.0304 | 0.0857 | 0.0872 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0942 | 0.2928 | 1 |
Mycobacterium leprae | putative cytochrome p450 | 0.0125 | 0.0273 | 0.5 |
Echinococcus granulosus | serine:threonine protein kinase 12 B | 0.0304 | 0.0857 | 0.0872 |
Loa Loa (eye worm) | hypothetical protein | 0.0131 | 0.0295 | 0.0678 |
Loa Loa (eye worm) | hypothetical protein | 0.016 | 0.0388 | 0.1007 |
Loa Loa (eye worm) | AUR protein kinase | 0.0304 | 0.0857 | 0.2669 |
Echinococcus granulosus | Serine:threonine protein kinase PLK4 | 0.2186 | 0.6968 | 1 |
Mycobacterium tuberculosis | Probable cytochrome P450 141 Cyp141 | 0.0125 | 0.0273 | 0.5 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0304 | 0.0857 | 0.0857 |
Echinococcus multilocularis | serine:threonine protein kinase 12 B | 0.0304 | 0.0857 | 0.0872 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0942 | 0.2928 | 1 |
Mycobacterium tuberculosis | Probable cytochrome P450 130 Cyp130 | 0.0125 | 0.0273 | 0.5 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.