TDR Targets

Basic information

Technical information

TDR Targets ID: 831314
Name: 6-methoxy-1-[(4-methylphenyl)methyl]-3-phenyl sulfonylquinolin-4-one
MW: 419.493 | Formula: C24H21NO4S
H donors: 0 H acceptors: 3 LogP: 4.53 Rotable bonds: 5
Rule of 5 violations (Lipinski): 1
SMILES: COc1ccc2c(c1)c(=O)c(cn2Cc1ccc(cc1)C)S(=O)(=O)c1ccccc1
InChi: 1S/C24H21NO4S/c1-17-8-10-18(11-9-17)15-25-16-23(30(27,28)20-6-4-3-5-7-20)24(26)21-14-19(29-2)12-13-22(21)25/h3-14,16H,15H2,1-2H3
InChiKey: WKSZNIRQUJNYFB-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

6-methoxy-1-[(4-methylphenyl)methyl]-3-phenylsulfonyl-quinolin-4-one
6-methoxy-1-[(4-methylphenyl)methyl]-3-phenylsulfonyl-4-quinolinone
6-methoxy-1-(4-methylbenzyl)-3-phenylsulfonyl-4-quinolone

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Giardia lamblia	Cathepsin B precursor	0.0184	0.0733	0.1868
Brugia malayi	prolyl oligopeptidase family protein	0.004	0.0074	0.0074
Loa Loa (eye worm)	hypothetical protein	0.0056	0.0145	0.0138
Plasmodium falciparum	serine repeat antigen 4	0.0184	0.0733	0.294
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0184	0.0733	0.1868
Plasmodium falciparum	dipeptidyl aminopeptidase 1	0.0184	0.0733	0.294
Echinococcus granulosus	prolyl endopeptidase	0.0154	0.0595	0.0567
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0184	0.0733	0.0726
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.0184	0.0733	0.1868
Echinococcus multilocularis	calpain family protein 1, d	0.0041	0.0078	0.0048
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0184	0.0733	0.1868
Schistosoma mansoni	hypothetical protein	0.0164	0.0642	0.0636
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0528	0.2313	0.6352
Onchocerca volvulus	Cathepsin L homolog	0.0184	0.0733	0.3077
Giardia lamblia	Encystation-specific protease	0.0184	0.0733	0.1868
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.0184	0.0733	0.1868
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0528	0.2313	0.6352
Leishmania major	prolyl oligopeptidase, putative,serine peptidase clan SC, family S9A, putative	0.0154	0.0595	0.1458
Trypanosoma brucei	histone deacetylase, putative	0.0042	0.0082	0.0023
Giardia lamblia	Cathepsin L precursor	0.0184	0.0733	0.1868
Loa Loa (eye worm)	ctsf protein	0.0528	0.2313	0.2307
Echinococcus multilocularis	acylamino acid releasing enzyme	0.004	0.0074	0.0044
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0528	0.2313	0.6352
Trypanosoma cruzi	hypothetical protein, conserved	0.004	0.0074	0.0067
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0528	0.2313	0.6352
Loa Loa (eye worm)	gamma-secretase subunit aph-1	0.0239	0.0984	0.0978
Mycobacterium tuberculosis	Probable protease II PtrBa [first part] (oligopeptidase B)	0.0114	0.041	1
Schistosoma mansoni	inhibitor of apoptosis (iap) domain family member	0.0093	0.0315	0.0308
Entamoeba histolytica	cysteine protease, putative	0.021	0.085	0.3467
Loa Loa (eye worm)	hypothetical protein	0.0031	0.003	0.0023
Loa Loa (eye worm)	hypothetical protein	0.0042	0.0082	0.0075
Onchocerca volvulus	Cathepsin L homolog	0.0528	0.2313	1
Loa Loa (eye worm)	hypothetical protein	0.0093	0.0315	0.0308
Schistosoma mansoni	family C2 unassigned peptidase (C02 family)	0.0058	0.0157	0.015
Echinococcus multilocularis	cathepsin b	0.2204	1	1
Brugia malayi	Inhibitor of Apoptosis domain containing protein	0.0093	0.0315	0.0315
Brugia malayi	Bromodomain containing protein	0.0037	0.006	0.006
Trypanosoma brucei	oligopeptidase b	0.0077	0.0245	0.0483
Echinococcus multilocularis	histone deacetylase	0.0042	0.0082	0.0052
Trypanosoma cruzi	dipeptidyl-peptidase 8-like serine peptidase	0.0128	0.0476	0.0469
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0622	0.2743	0.7571
Plasmodium falciparum	serine repeat antigen 5	0.0184	0.0733	0.294
Echinococcus granulosus	family C2 unassigned peptidase C02 family	0.0058	0.0157	0.0127
Onchocerca volvulus	Deterin homolog	0.0093	0.0315	0.1248
Echinococcus multilocularis	calpain A	0.0058	0.0157	0.0127
Onchocerca volvulus	Cathepsin L homolog	0.0528	0.2313	1
Brugia malayi	prolyl oligopeptidase family protein	0.004	0.0074	0.0074
Loa Loa (eye worm)	hypothetical protein	0.0528	0.2313	0.2307
Entamoeba histolytica	cysteine protease, putative	0.0184	0.0733	0.294
Echinococcus granulosus	acylamino acid releasing enzyme	0.004	0.0074	0.0044
Echinococcus granulosus	histone deacetylase 6	0.0042	0.0082	0.0052
Brugia malayi	Histone deacetylase family protein	0.0042	0.0082	0.0082
Entamoeba histolytica	cysteine protease, putative	0.021	0.085	0.3467
Echinococcus granulosus	histone deacetylase 6	0.0042	0.0082	0.0052
Entamoeba histolytica	cysteine protease, putative	0.021	0.085	0.3467
Schistosoma mansoni	hypothetical protein	0.0164	0.0642	0.0636
Plasmodium falciparum	histone deacetylase 2	0.0042	0.0082	0.0037
Plasmodium vivax	histone deacetylase 2, putative	0.0042	0.0082	0.0326
Schistosoma mansoni	dipeptidyl-peptidase 9 (S09 family)	0.0128	0.0476	0.0469
Trypanosoma cruzi	cysteine peptidase, putative	0.0622	0.2743	0.2737
Echinococcus granulosus	bromodomain adjacent to zinc finger domain	0.0058	0.0155	0.0125
Trypanosoma brucei	serine peptidase, clan SC, family S9A-like protein	0.0077	0.0245	0.0483
Giardia lamblia	Cathepsin B precursor	0.0184	0.0733	0.1868
Loa Loa (eye worm)	hypothetical protein	0.0069	0.0204	0.0197
Brugia malayi	Papain family cysteine protease containing protein	0.0184	0.0733	0.0733
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.021	0.085	0.0844
Schistosoma mansoni	subfamily C1A unassigned peptidase (C01 family)	0.0184	0.0733	0.0726
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0503	0.2195	0.6017
Leishmania major	cathepsin L-like protease	0.0622	0.2743	0.7565
Plasmodium falciparum	serine repeat antigen 9	0.0184	0.0733	0.294
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0528	0.2313	0.6352
Echinococcus granulosus	histone deacetylase 6	0.0042	0.0082	0.0052
Giardia lamblia	Cathepsin B precursor	0.0809	0.3599	1
Loa Loa (eye worm)	calpain family protein 1	0.0041	0.0078	0.0071
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0528	0.2313	0.6352
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0528	0.2313	0.6352
Brugia malayi	Cathepsin L-like precursor	0.0528	0.2313	0.2313
Leishmania major	oligopeptidase B-like protein,serine peptidase, clan SC, family S9A-like protein	0.0077	0.0245	0.0461
Leishmania major	cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like	0.0809	0.3599	1
Echinococcus multilocularis	gamma secretase subunit aph 1	0.0239	0.0984	0.0957
Brugia malayi	Papain family cysteine protease containing protein	0.0184	0.0733	0.0733
Schistosoma mansoni	subfamily S9B unassigned peptidase (S09 family)	0.0354	0.1514	0.1508
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0528	0.2313	0.6352
Entamoeba histolytica	cysteine proteinase, putative	0.0503	0.2195	0.9473
Trypanosoma brucei	histone deacetylase 4	0.0042	0.0082	0.0023
Brugia malayi	Cell death protein 3 precursor	0.0031	0.003	0.003
Echinococcus multilocularis	bromodomain adjacent to zinc finger domain	0.0035	0.0049	0.0019
Toxoplasma gondii	dipeptidyl peptidase iv (dpp iv) n-terminal region domain-containing protein	0.0128	0.0476	0.114
Plasmodium vivax	unspecified product	0.021	0.085	0.3657
Plasmodium falciparum	serine repeat antigen 8	0.0184	0.0733	0.294
Trypanosoma cruzi	hypothetical protein, conserved	0.004	0.0074	0.0067
Trypanosoma cruzi	histone deacetylase, putative	0.0042	0.0082	0.0075
Schistosoma mansoni	cathepsin B (C01 family)	0.0184	0.0733	0.0726
Entamoeba histolytica	cysteine protease, putative	0.0184	0.0733	0.294
Giardia lamblia	Cysteine protease	0.0184	0.0733	0.1868
Brugia malayi	hypothetical protein	0.0031	0.003	0.003
Trypanosoma cruzi	serine peptidase, Clan SC, Family S9B	0.0128	0.0476	0.0469
Entamoeba histolytica	cysteine proteinase, putative	0.021	0.085	0.3467
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.021	0.085	0.0844
Loa Loa (eye worm)	hypothetical protein	0.0184	0.0733	0.0726
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0503	0.2195	0.6017
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.021	0.085	0.2202
Brugia malayi	Papain family cysteine protease containing protein	0.021	0.085	0.085
Entamoeba histolytica	cysteine proteinase, putative	0.021	0.085	0.3467
Brugia malayi	cathepsin F-like cysteine proteinase	0.0026	0.0007	0.0007
Entamoeba histolytica	cysteine protease, putative	0.021	0.085	0.3467
Trypanosoma cruzi	prolyl endopeptidase	0.0154	0.0595	0.0588
Trypanosoma cruzi	oligopeptidase b	0.0077	0.0245	0.0238
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0622	0.2743	0.7571
Schistosoma mansoni	cathepsin S (C01 family)	0.0184	0.0733	0.0726
Onchocerca volvulus		0.0528	0.2313	1
Trypanosoma cruzi	major cysteine proteinase, putative	0.0184	0.0733	0.0726
Plasmodium falciparum	cysteine proteinase falcipain 2a	0.0528	0.2313	1
Schistosoma mansoni	cathepsin C	0.0184	0.0733	0.0726
Entamoeba histolytica	cysteine protease, putative	0.021	0.085	0.3467
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0528	0.2313	0.6352
Echinococcus multilocularis	Dipeptidyl peptidase 9	0.0128	0.0476	0.0447
Echinococcus granulosus	Dipeptidyl peptidase 9	0.0128	0.0476	0.0447
Loa Loa (eye worm)	hypothetical protein	0.0503	0.2195	0.2189
Echinococcus multilocularis	cysteine protease	0.0528	0.2313	0.229
Echinococcus multilocularis	inhibitor of apoptosis protein	0.0093	0.0315	0.0286
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0184	0.0733	0.1868
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0528	0.2313	0.6352
Giardia lamblia	Cathepsin L-like protease	0.0184	0.0733	0.1868
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0528	0.2313	0.6352
Giardia lamblia	Cathepsin L-like protease	0.0184	0.0733	0.1868
Plasmodium falciparum	dipeptidyl aminopeptidase 3	0.0184	0.0733	0.294
Loa Loa (eye worm)	hypothetical protein	0.0503	0.2195	0.2189
Echinococcus multilocularis	geminin	0.0164	0.0642	0.0614
Onchocerca volvulus		0.0528	0.2313	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0622	0.2743	0.7571
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0528	0.2313	0.6352
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0184	0.0733	0.1868
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0622	0.2743	0.7571
Brugia malayi	prolyl oligopeptidase family protein	0.0128	0.0476	0.0476
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0809	0.3599	0.3594
Echinococcus multilocularis	cathepsin L cysteine protease	0.0528	0.2313	0.229
Loa Loa (eye worm)	histone deacetylase 7A	0.0042	0.0082	0.0075
Echinococcus granulosus	cathepsin b	0.2204	1	1
Brugia malayi	gamma-secretase subunit aph-1	0.0239	0.0984	0.0984
Brugia malayi	Papain family cysteine protease containing protein	0.0184	0.0733	0.0733
Loa Loa (eye worm)	hypothetical protein	0.0039	0.007	0.0063
Echinococcus granulosus	cathepsin b	0.2204	1	1
Trypanosoma brucei	Dipeptidyl-peptidase 8-like, putative	0.0128	0.0476	0.114
Echinococcus granulosus	bromodomain adjacent to zinc finger domain	0.0035	0.0049	0.0019
Entamoeba histolytica	cysteine protease, putative	0.021	0.085	0.3467
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0184	0.0733	0.1868
Trichomonas vaginalis	Clan CA, family C1, cathepsin H-like cysteine peptidase	0.0184	0.0733	0.1868
Brugia malayi	cathepsin L precursor	0.0184	0.0733	0.0733
Giardia lamblia	Hypothetical protein	0.0184	0.0733	0.1868
Trypanosoma cruzi	cysteine peptidase, putative	0.0622	0.2743	0.2737
Toxoplasma gondii	cathepsin B	0.0809	0.3599	1
Trypanosoma cruzi	oligopeptidase b	0.0077	0.0245	0.0238
Giardia lamblia	Cysteine protease	0.0184	0.0733	0.1868
Brugia malayi	Cathepsin L-like precursor	0.0503	0.2195	0.2195
Plasmodium vivax	vivapain-2	0.0528	0.2313	1
Loa Loa (eye worm)	hypothetical protein	0.0184	0.0733	0.0726
Schistosoma mansoni	subfamily C1A unassigned peptidase (C01 family)	0.0184	0.0733	0.0726
Trypanosoma cruzi	cysteine proteinase, putative	0.021	0.085	0.0844
Mycobacterium leprae	PROBABLE PROTEASE II PTRBB (OLIGOPEPTIDASE B)	0.0077	0.0245	0.5
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0078	0.0071
Leishmania major	cathepsin L-like protease	0.0528	0.2313	0.6343
Loa Loa (eye worm)	hypothetical protein	0.0031	0.003	0.0023
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0184	0.0733	0.0726
Echinococcus multilocularis	baculoviral IAP repeat containing protein	0.0093	0.0315	0.0286
Loa Loa (eye worm)	fibroinase	0.0528	0.2313	0.2307
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0622	0.2743	0.7571
Entamoeba histolytica	cysteine protease, putative	0.021	0.085	0.3467
Trypanosoma brucei	prolyl oligopeptidase, putative	0.0077	0.0245	0.0483
Plasmodium falciparum	histone deacetylase, putative	0.0042	0.0082	0.0037
Plasmodium falciparum	serine repeat antigen 3	0.0184	0.0733	0.294
Entamoeba histolytica	papain family cysteine protease domain containing protein	0.0184	0.0733	0.294
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0184	0.0733	0.1868
Loa Loa (eye worm)	calpain family protein 1	0.0056	0.0145	0.0138
Echinococcus granulosus	cathepsin l1	0.0528	0.2313	0.229
Trichomonas vaginalis	conserved hypothetical protein	0.0184	0.0733	0.1868
Giardia lamblia	Cathepsin B precursor	0.0809	0.3599	1
Toxoplasma gondii	prolyl endopeptidase	0.0154	0.0595	0.1478
Giardia lamblia	Cathepsin L precursor	0.0184	0.0733	0.1868
Brugia malayi	Cathepsin L-like cysteine proteinase	0.0503	0.2195	0.2195
Schistosoma mansoni	prolyl oligopeptidase (S09 family)	0.0154	0.0595	0.0588
Schistosoma mansoni	caspase-7 (C14 family)	0.0031	0.003	0.0023
Echinococcus multilocularis	histone deacetylase 6	0.0042	0.0082	0.0052
Trypanosoma cruzi	oligopeptidase B-like protein, putative	0.0077	0.0245	0.0238
Brugia malayi	prolyl oligopeptidase family protein	0.0354	0.1514	0.1514
Giardia lamblia	Cysteine protease	0.0184	0.0733	0.1868
Brugia malayi	calpain family protein 1	0.0056	0.0145	0.0145
Leishmania major	cysteine peptidase A (CPA)	0.0528	0.2313	0.6343
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.021	0.085	0.2202
Trypanosoma cruzi	histone deacetylase, putative	0.0042	0.0082	0.0075
Loa Loa (eye worm)	hypothetical protein	0.0184	0.0733	0.0726
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0622	0.2743	0.7571
Echinococcus granulosus	inhibitor of apoptosis protein	0.0093	0.0315	0.0286
Plasmodium vivax	serine-repeat antigen (SERA)	0.0184	0.0733	0.3146
Toxoplasma gondii	histone deacetylase HDAC1	0.0042	0.0082	0.0023
Loa Loa (eye worm)	cysteine proteinase cathepsin Z	0.0184	0.0733	0.0726
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0079	0.0072
Trypanosoma cruzi	serine peptidase, clan SC, family S9A-like protein, putative	0.0077	0.0245	0.0238
Echinococcus multilocularis	prolyl endopeptidase	0.0154	0.0595	0.0567
Giardia lamblia	Cathepsin L precursor	0.0184	0.0733	0.1868
Echinococcus granulosus	calpain A	0.0058	0.0157	0.0127
Onchocerca volvulus		0.0503	0.2195	0.9483
Leishmania major	cathepsin L-like protease	0.0622	0.2743	0.7565
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0528	0.2313	0.6352
Loa Loa (eye worm)	hypothetical protein	0.0093	0.0315	0.0308
Trypanosoma brucei	serine peptidase, Clan SC, Family S9B	0.0128	0.0476	0.114
Entamoeba histolytica	cysteine proteinase, putative	0.0528	0.2313	1
Echinococcus granulosus	histone deacetylase	0.0042	0.0082	0.0052
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0528	0.2313	0.6352
Plasmodium vivax	serine-repeat antigen 3 (SERA)	0.0184	0.0733	0.3146
Echinococcus multilocularis	family C2 unassigned peptidase (C02 family)	0.0058	0.0157	0.0127
Echinococcus multilocularis	cathepsin b	0.2204	1	1
Loa Loa (eye worm)	prolyl oligopeptidase	0.004	0.0074	0.0067
Leishmania major	cathepsin L-like protease	0.0622	0.2743	0.7565
Entamoeba histolytica	cysteine proteinase 2	0.021	0.085	0.3467
Brugia malayi	hypothetical protein	0.0088	0.0291	0.0291
Trypanosoma cruzi	Aph-1 protein, putative	0.0093	0.0316	0.0309
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0528	0.2313	0.6352
Giardia lamblia	Dipeptidyl-peptidase I precursor	0.0184	0.0733	0.1868
Schistosoma mansoni	cathepsin F (C01 family)	0.0528	0.2313	0.2307
Brugia malayi	cahepsin L-like non-peptiedase homolog	0.0184	0.0733	0.0733
Leishmania major	cathepsin L-like protease	0.0528	0.2313	0.6343
Echinococcus multilocularis	histone deacetylase 6	0.0042	0.0082	0.0052
Echinococcus granulosus	cathepsin L cysteine proteinase	0.0528	0.2313	0.229
Trypanosoma brucei	histone deacetylase 3	0.0042	0.0082	0.0023
Echinococcus multilocularis	cathepsin L	0.021	0.085	0.0823
Toxoplasma gondii	cathepsin CPL	0.0528	0.2313	0.6352
Brugia malayi	prolyl oligopeptidase family protein	0.0154	0.0595	0.0595
Echinococcus granulosus	cysteine protease	0.021	0.085	0.0823
Echinococcus multilocularis	cathepsin L	0.0184	0.0733	0.0704
Plasmodium vivax	serine-repeat antigen 2 (SERA)	0.0184	0.0733	0.3146
Schistosoma mansoni	family C2 unassigned peptidase (C02 family)	0.0056	0.0145	0.0138
Giardia lamblia	Cathepsin L precursor	0.0184	0.0733	0.1868
Onchocerca volvulus		0.0035	0.0049	0.0081
Brugia malayi	cathepsin Z-like cysteine proteinase	0.0184	0.0733	0.0733
Entamoeba histolytica	cysteine protease, putative	0.0184	0.0733	0.294
Loa Loa (eye worm)	cathepsin B	0.0809	0.3599	0.3594
Echinococcus multilocularis	cathepsin L cysteine protease	0.0528	0.2313	0.229
Plasmodium vivax	serine-repeat antigen 4 (SERA), putative	0.0184	0.0733	0.3146
Loa Loa (eye worm)	hypothetical protein	0.0088	0.0291	0.0284
Plasmodium vivax	dipeptidyl aminopeptidase 1, putative	0.0184	0.0733	0.3146
Plasmodium vivax	vivapain-1	0.021	0.085	0.3657
Trypanosoma cruzi	Aph-1 protein, putative	0.0093	0.0316	0.0309
Entamoeba histolytica	cysteine protease, putative	0.0184	0.0733	0.294
Schistosoma mansoni	histone deacetylase 4 5	0.0042	0.0082	0.0075
Brugia malayi	cathepsin Z-like cysteine proteinase	0.0184	0.0733	0.0733
Brugia malayi	Papain family cysteine protease containing protein	0.021	0.085	0.085
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.2204	1	1
Onchocerca volvulus		0.0528	0.2313	1
Schistosoma mansoni	prolyl oligopeptidase (S09 family)	0.004	0.0074	0.0067
Schistosoma mansoni	SmCB2 peptidase (C01 family)	0.2204	1	1
Schistosoma mansoni	gamma-secretase subunit aph-1	0.0239	0.0984	0.0978
Schistosoma mansoni	prolyl oligopeptidase (S09 family)	0.0154	0.0595	0.0588
Brugia malayi	Inhibitor of Apoptosis domain containing protein	0.0093	0.0315	0.0315
Trypanosoma brucei	prolyl endopeptidase	0.0154	0.0595	0.1478
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.021	0.085	0.0844
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0184	0.0733	0.0726
Entamoeba histolytica	cysteine proteinase, putative	0.021	0.085	0.3467
Echinococcus granulosus	dipeptidyl aminopeptidaseprotein	0.0354	0.1514	0.1488
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0528	0.2313	0.6352
Brugia malayi	cathepsin L-like cysteine proteinase	0.0184	0.0733	0.0733
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.2204	1	1
Trypanosoma cruzi	cysteine proteinase, putative	0.021	0.085	0.0844
Schistosoma mansoni	inhibitor of apoptosis protein	0.0093	0.0315	0.0308
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0184	0.0733	0.0726
Loa Loa (eye worm)	hypothetical protein	0.0503	0.2195	0.2189
Loa Loa (eye worm)	hypothetical protein	0.0184	0.0733	0.0726
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0622	0.2743	0.7571
Schistosoma mansoni	histone deacetylase 4 5	0.0042	0.0082	0.0075
Entamoeba histolytica	cysteine protease, putative	0.0528	0.2313	1
Echinococcus granulosus	cathepsin L	0.021	0.085	0.0823
Plasmodium falciparum	serine repeat antigen 1	0.0184	0.0733	0.294
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0528	0.2313	0.6352
Brugia malayi	cathepsin L-like cysteine proteinase, identical	0.0026	0.0007	0.0007
Plasmodium vivax	vivapain-3	0.021	0.085	0.3657
Plasmodium vivax	serine-repeat antigen (SERA), putative	0.0184	0.0733	0.3146
Echinococcus granulosus	cathepsin l cysteine peptidase	0.0528	0.2313	0.229
Mycobacterium ulcerans	protease II (oligopeptidase B), PtrB	0.0077	0.0245	0.5
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0528	0.2313	0.2307
Plasmodium vivax	serine-repeat antigen (SERA), putative	0.0184	0.0733	0.3146
Leishmania major	cathepsin L-like protease	0.0528	0.2313	0.6343
Plasmodium falciparum	cysteine proteinase falcipain 2b	0.0528	0.2313	1
Giardia lamblia	Dipeptidyl-peptidase I precursor	0.0184	0.0733	0.1868
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0622	0.2743	0.7571
Schistosoma mansoni	dipeptidyl-peptidase I (C01 family)	0.0184	0.0733	0.0726
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0622	0.2743	0.7571
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0184	0.0733	0.0726
Plasmodium vivax	hypothetical protein, conserved	0.004	0.0074	0.0291
Brugia malayi	Cathepsin L-like precursor	0.0026	0.0007	0.0007
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.2204	1	1
Brugia malayi	Papain family cysteine protease containing protein	0.0528	0.2313	0.2313
Loa Loa (eye worm)	prolyl oligopeptidase	0.0354	0.1514	0.1508
Echinococcus granulosus	histone deacetylase 7	0.0042	0.0082	0.0052
Entamoeba histolytica	cysteine protease, putative	0.021	0.085	0.3467
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.0809	0.3599	1
Giardia lamblia	Cathepsin B precursor	0.0184	0.0733	0.1868
Plasmodium falciparum	cysteine proteinase falcipain 3	0.0528	0.2313	1
Entamoeba histolytica	cysteine protease, putative	0.021	0.085	0.3467
Plasmodium falciparum	serine repeat antigen 6	0.0184	0.0733	0.294
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0184	0.0733	0.0726
Trypanosoma cruzi	major cysteine proteinase, putative	0.0278	0.1162	0.1156
Trichomonas vaginalis	conserved hypothetical protein	0.0184	0.0733	0.1868
Loa Loa (eye worm)	hypothetical protein	0.0042	0.0082	0.0075
Echinococcus multilocularis	cysteine protease	0.0528	0.2313	0.229
Trichomonas vaginalis	Clan CA, family C1, cathepsin F-like cysteine peptidase	0.0184	0.0733	0.1868
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0184	0.0733	0.1868
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0528	0.2313	0.6352
Loa Loa (eye worm)	hypothetical protein	0.0049	0.0116	0.0109
Echinococcus multilocularis	histone deacetylase 6	0.0042	0.0082	0.0052
Trypanosoma cruzi	cysteine peptidase, putative	0.0528	0.2313	0.2307
Leishmania major	dipeptidyl-peptidase 8-like serine peptidase, putative,serine peptidase, Clan SC, Family S9B	0.0128	0.0476	0.1119
Entamoeba histolytica	cysteine protease, putative	0.021	0.085	0.3467
Toxoplasma gondii	cathepsin CPC1	0.0184	0.0733	0.1868
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0528	0.2313	0.6352
Toxoplasma gondii	cathepsin CPC2	0.0184	0.0733	0.1868
Plasmodium vivax	dipeptidyl aminopeptidase 2, putative	0.0184	0.0733	0.3146
Echinococcus granulosus	geminin	0.0164	0.0642	0.0614
Trypanosoma brucei	cysteine peptidase C (CPC)	0.0809	0.3599	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0528	0.2313	0.6352
Trypanosoma cruzi	cysteine protease, putative	0.021	0.085	0.0844
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0184	0.0733	0.0726
Onchocerca volvulus		0.0528	0.2313	1
Entamoeba histolytica	hypothetical protein	0.0184	0.0733	0.294
Trypanosoma cruzi	cruzipain precursor, putative	0.0622	0.2743	0.2737
Brugia malayi	cathepsin F-like cysteine proteinase	0.0184	0.0733	0.0733
Entamoeba histolytica	cysteine proteinase, putative	0.0528	0.2313	1
Entamoeba histolytica	cysteine protease, putative	0.021	0.085	0.3467
Trypanosoma cruzi	cysteine peptidase, putative	0.0622	0.2743	0.2737
Onchocerca volvulus	Prolyl endopeptidase homolog	0.0154	0.0595	0.2475
Onchocerca volvulus		0.0093	0.0315	0.1248
Entamoeba histolytica	cysteine protease, putative	0.0184	0.0733	0.294
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0528	0.2313	0.229
Schistosoma mansoni	hypothetical protein	0.0031	0.003	0.0023
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0528	0.2313	0.6352
Entamoeba histolytica	cysteine protease, putative	0.0184	0.0733	0.294
Schistosoma mansoni	histone deacetylase hda2	0.0042	0.0082	0.0075
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0184	0.0733	0.1868
Entamoeba histolytica	cysteine protease, putative	0.021	0.085	0.3467
Entamoeba histolytica	cysteine protease, putative	0.021	0.085	0.3467
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	0.0809	0.3599	0.3594
Brugia malayi	cathepsin L-like precursor	0.0503	0.2195	0.2195
Loa Loa (eye worm)	hypothetical protein	0.004	0.0074	0.0067
Schistosoma mansoni	acylaminoacyl-peptidase (S09 family)	0.004	0.0074	0.0067
Plasmodium vivax	histone deacetylase, putative	0.0042	0.0082	0.0326
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.0184	0.0733	0.1868
Entamoeba histolytica	cysteine proteinase 1, putative	0.021	0.085	0.3467
Onchocerca volvulus	Dipeptidyl peptidase family member 1 homolog	0.0354	0.1514	0.65
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.021	0.085	0.2202
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.021	0.085	0.2202
Trypanosoma cruzi	histone deacetylase, putative	0.0042	0.0082	0.0075
Echinococcus granulosus	cathepsin L	0.0184	0.0733	0.0704
Plasmodium falciparum	dipeptidyl aminopeptidase 2	0.0184	0.0733	0.294
Echinococcus granulosus	baculoviral IAP repeat containing protein	0.0093	0.0315	0.0286
Brugia malayi	fibroinase precursor	0.0184	0.0733	0.0733
Echinococcus granulosus	gamma secretase subunit aph 1	0.0239	0.0984	0.0957
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0528	0.2313	0.6352
Loa Loa (eye worm)	hypothetical protein	0.2204	1	1
Onchocerca volvulus	Cathepsin F homolog	0.0528	0.2313	1
Giardia lamblia	Cathepsin B precursor	0.0184	0.0733	0.1868
Schistosoma mansoni	subfamily C1A non-peptidase homologue (C01 family)	0.0184	0.0733	0.0726
Echinococcus multilocularis	histone deacetylase 7	0.0042	0.0082	0.0052
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	0.2204	1	1
Schistosoma mansoni	hypothetical protein	0.0093	0.0315	0.0308
Plasmodium vivax	dipeptidyl aminopeptidase 3, putative	0.0184	0.0733	0.3146
Plasmodium falciparum	cysteine proteinase falcipain 1	0.021	0.085	0.3467
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0049	0.0042
Trypanosoma cruzi	cysteine peptidase (N-terminal), putative	0.021	0.085	0.0844
Onchocerca volvulus		0.0528	0.2313	1
Brugia malayi	Cathepsin L-like precursor	0.0528	0.2313	0.2313
Brugia malayi	calpain family protein 1	0.0056	0.0145	0.0145
Loa Loa (eye worm)	histone deacetylase	0.0042	0.0082	0.0075
Plasmodium vivax	serine-repeat antigen 4 (SERA)	0.0184	0.0733	0.3146
Giardia lamblia	Cathepsin L precursor	0.0184	0.0733	0.1868
Loa Loa (eye worm)	hypothetical protein	0.0184	0.0733	0.0726
Echinococcus granulosus	cathepsin l1	0.0503	0.2195	0.2171
Echinococcus multilocularis	dipeptidyl aminopeptidaseprotein	0.0354	0.1514	0.1488
Giardia lamblia	Cathepsin L precursor	0.0184	0.0733	0.1868
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or H-like cysteine peptidase	0.0184	0.0733	0.1868
Loa Loa (eye worm)	hypothetical protein	0.004	0.0074	0.0067
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0622	0.2743	0.7571
Giardia lamblia	Cathepsin B precursor	0.0809	0.3599	1
Brugia malayi	Cathepsin L-like precursor	0.0528	0.2313	0.2313
Brugia malayi	Cathepsin L-like precursor	0.0528	0.2313	0.2313
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0528	0.2313	0.229
Echinococcus multilocularis	bromodomain adjacent to zinc finger domain	0.0058	0.0155	0.0125
Trypanosoma cruzi	cysteine peptidase, putative	0.021	0.085	0.0844
Echinococcus granulosus	cathepsin L cysteine protease	0.021	0.085	0.0823
Onchocerca volvulus		0.0528	0.2313	1
Trypanosoma brucei	Aph-1 protein, putative	0.0093	0.0316	0.0686
Entamoeba histolytica	papain family cysteine protease domain containing protein	0.0184	0.0733	0.294
Plasmodium falciparum	serine repeat antigen 7	0.0184	0.0733	0.294
Trichomonas vaginalis	Clan CA, family C1, cathepsin L, S or H-like cysteine peptidase	0.0184	0.0733	0.1868
Plasmodium vivax	vivapain-2	0.0528	0.2313	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0184	0.0733	0.1868
Trypanosoma cruzi	cysteine peptidase, clan CA, family C1, cathepsin L-like, putative	0.0596	0.2625	0.2619
Onchocerca volvulus		0.0184	0.0733	0.3077
Schistosoma mansoni	cathepsin F (C01 family)	0.0528	0.2313	0.2307
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0528	0.2313	0.6352
Giardia lamblia	Hypothetical protein	0.0184	0.0733	0.1868
Loa Loa (eye worm)	cysteine protease	0.0528	0.2313	0.2307
Onchocerca volvulus		0.0528	0.2313	1
Toxoplasma gondii	preprocathepsin c precursor, putative	0.0184	0.0733	0.1868
Loa Loa (eye worm)	Papain cysteine protease/cathepsin propeptide inhibitor-containing protein	0.0528	0.2313	0.2307
Giardia lamblia	Cathepsin B precursor	0.0184	0.0733	0.1868
Brugia malayi	Cathepsin L-like precursor	0.0528	0.2313	0.2313
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0528	0.2313	0.6352
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0528	0.2313	0.6352
Loa Loa (eye worm)	hypothetical protein	0.0184	0.0733	0.0726
Leishmania major	cathepsin L-like protease	0.0528	0.2313	0.6343
Schistosoma mansoni	bromodomain containing protein	0.0061	0.0171	0.0163
Plasmodium vivax	serine-repeat antigen 5 (SERA)	0.0184	0.0733	0.3146
Leishmania major	cathepsin L-like protease	0.0528	0.2313	0.6343
Giardia lamblia	Cysteine protease	0.0184	0.0733	0.1868
Schistosoma mansoni	family C2 unassigned peptidase (C02 family)	0.0058	0.0157	0.015
Schistosoma mansoni	cathepsin F (C01 family)	0.0503	0.2195	0.2189
Brugia malayi	Cathepsin L-like precursor	0.0503	0.2195	0.2195
Plasmodium vivax	serine-repeat antigen (SERA)	0.0184	0.0733	0.3146
Brugia malayi	Histone deacetylase family protein	0.0042	0.0082	0.0082
Loa Loa (eye worm)	hypothetical protein	0.0037	0.006	0.0053
Loa Loa (eye worm)	hypothetical protein	0.0154	0.0595	0.0588
Plasmodium vivax	unspecified product	0.0184	0.0733	0.3146
Entamoeba histolytica	cysteine proteinase, putative	0.021	0.085	0.3467
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0622	0.2743	0.7571
Giardia lamblia	Cathepsin B-like cysteine proteinase 3 precursor	0.0184	0.0733	0.1868
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.0184	0.0733	0.1868
Brugia malayi	Bromodomain containing protein	0.0073	0.0223	0.0223
Brugia malayi	Cathepsin L-like precursor	0.0528	0.2313	0.2313
Plasmodium falciparum	serine repeat antigen 2	0.0184	0.0733	0.294
Giardia lamblia	Dipeptidyl-peptidase I precursor	0.0184	0.0733	0.1868
Leishmania major	oligopeptidase b	0.0077	0.0245	0.0461

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

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Bibliographic References

No literature references available for this target.

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Detailed information for compound 831314