Detailed information for compound 832112

Basic information

Technical information
  • TDR Targets ID: 832112
  • Name: N-(4-chloro-2-fluorophenyl)-2-[2-[(2-methylph enyl)methylsulfanyl]imidazo[5,4-c]pyridin-3-y l]acetamide
  • MW: 440.921 | Formula: C22H18ClFN4OS
  • H donors: 1 H acceptors: 3 LogP: 4.8 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(Cn1c(SCc2ccccc2C)nc2c1cncc2)Nc1ccc(cc1F)Cl
  • InChi: 1S/C22H18ClFN4OS/c1-14-4-2-3-5-15(14)13-30-22-27-19-8-9-25-11-20(19)28(22)12-21(29)26-18-7-6-16(23)10-17(18)24/h2-11H,12-13H2,1H3,(H,26,29)
  • InChiKey: OEQCUMZYLWNFGT-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N-(4-chloro-2-fluoro-phenyl)-2-[2-[(2-methylphenyl)methylsulfanyl]imidazo[5,4-c]pyridin-3-yl]acetamide
  • N-(4-chloro-2-fluorophenyl)-2-[2-[(2-methylphenyl)methylthio]-3-imidazo[5,4-c]pyridinyl]acetamide
  • N-(4-chloro-2-fluoro-phenyl)-2-[2-[(2-methylbenzyl)thio]imidazo[5,4-c]pyridin-3-yl]acetamide
  • N-(4-chloro-2-fluoro-phenyl)-2-[2-[(2-methylphenyl)methylsulfanyl]imidazo[5,4-c]pyridin-3-yl]ethanamide

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.046 0.4404 0.678
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0111 0.033 0.0285
Schistosoma mansoni adam (A disintegrin and metalloprotease 0.013 0.0554 0.0855
Brugia malayi Papain family cysteine protease containing protein 0.0111 0.033 0.0434
Trypanosoma cruzi metacaspase, putative 0.0248 0.1924 0.368
Loa Loa (eye worm) hypothetical protein 0.0157 0.0872 0.1298
Trichomonas vaginalis conserved hypothetical protein 0.0248 0.1924 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0111 0.033 0.0285
Schistosoma mansoni multidrug resistance protein 0.0107 0.0283 0.0437
Loa Loa (eye worm) hypothetical protein 0.0107 0.0283 0.0385
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0111 0.033 0.0285
Plasmodium falciparum multidrug resistance protein 1 0.0107 0.0283 0.0267
Echinococcus multilocularis ATP binding cassette sub family B 0.0106 0.027 0.0256
Leishmania major cathepsin L-like protease 0.0111 0.033 0.0107
Loa Loa (eye worm) hypothetical protein 0.0241 0.1848 0.2813
Brugia malayi Disintegrin family protein 0.0121 0.0449 0.0619
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0237 0.1799 0.9239
Leishmania major cathepsin L-like protease 0.0111 0.033 0.0107
Onchocerca volvulus Cathepsin L homolog 0.0111 0.033 0.0418
Entamoeba histolytica cysteine proteinase, putative 0.0111 0.033 0.0048
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0111 0.033 0.0285
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0111 0.033 0.0285
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0111 0.033 0.0285
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0111 0.033 0.0285
Schistosoma mansoni hypothetical protein 0.0247 0.1918 0.296
Loa Loa (eye worm) angiotensin-converting enzyme family protein 0.062 0.6267 0.9671
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP 0.0107 0.0283 0.0271
Schistosoma mansoni ADAMTS5 peptidase (M12 family) 0.0087 0.0051 0.0078
Plasmodium vivax dipeptidyl aminopeptidase 1, putative 0.0221 0.1619 0.8187
Loa Loa (eye worm) matrixin family protein 0.0499 0.4862 0.749
Loa Loa (eye worm) hypothetical protein 0.0133 0.0592 0.0865
Plasmodium vivax multidrug resistance protein 1, putative 0.0107 0.0283 0.0267
Brugia malayi Cell death protein 3 precursor 0.0638 0.6479 1
Mycobacterium tuberculosis Probable peptidoglycan hydrolase 0.0258 0.2048 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0111 0.033 0.0285
Schistosoma mansoni caspase-7 (C14 family) 0.0638 0.6479 1
Echinococcus granulosus matrix metallopeptidase 7 M10 family 0.0872 0.9211 1
Toxoplasma gondii ABC transporter transmembrane region domain-containing protein 0.0107 0.0283 0.0077
Plasmodium falciparum cysteine proteinase falcipain 3 0.0111 0.033 0.0545
Schistosoma mansoni caspase-7 (C14 family) 0.0393 0.3621 0.5589
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0157 0.0872 0.1345
Echinococcus granulosus dipeptidyl aminopeptidaseprotein 0.029 0.2415 0.2594
Echinococcus multilocularis caspase 2 0.0638 0.6479 0.7023
Echinococcus granulosus caspase 3 apoptosis cysteine peptidase 0.0393 0.3621 0.3908
Brugia malayi Copper type II ascorbate-dependent monooxygenase, C-terminal domain containing protein 0.046 0.4404 0.6772
Trypanosoma brucei Metacaspase-4 0.0248 0.1924 0.368
Echinococcus granulosus caspase 2 0.0638 0.6479 0.7023
Loa Loa (eye worm) hypothetical protein 0.0313 0.2688 0.4117
Brugia malayi prolyl oligopeptidase family protein 0.029 0.2415 0.3677
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0111 0.033 0.0285
Plasmodium falciparum plasmepsin I 0.0115 0.0376 0.0816
Trypanosoma cruzi metacaspase, putative 0.0248 0.1924 0.368
Entamoeba histolytica cysteine protease, putative 0.0111 0.033 0.0048
Brugia malayi Copper type II ascorbate-dependent monooxygenase, C-terminal domain containing protein 0.012 0.0439 0.0603
Echinococcus multilocularis caspase 3, apoptosis cysteine peptidase 0.0393 0.3621 0.3908
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0107 0.0283 0.0271
Loa Loa (eye worm) hypothetical protein 0.0247 0.1918 0.2922
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0111 0.033 0.0285
Echinococcus granulosus caspase 0.0393 0.3621 0.3908
Plasmodium vivax vivapain-2 0.0111 0.033 0.0545
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0111 0.033 0.0285
Brugia malayi cathepsin Z-like cysteine proteinase 0.0237 0.1799 0.272
Trypanosoma brucei serine peptidase, Clan SC, Family S9B 0.0286 0.2372 0.4714
Mycobacterium leprae PROBABLE HYDROLASE 0.0258 0.2048 0.5
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0248 0.1924 1
Schistosoma mansoni cathepsin F (C01 family) 0.0111 0.033 0.0509
Loa Loa (eye worm) hypothetical protein 0.0638 0.6479 1
Loa Loa (eye worm) ATP-binding cassette sub-family B member 2 0.0107 0.0283 0.0385
Echinococcus granulosus Blood coagulation inhibitor Disintegrin 0.019 0.1256 0.1331
Brugia malayi Cathepsin L-like precursor 0.0111 0.033 0.0434
Brugia malayi ABC transporter family protein 0.0107 0.0283 0.0362
Loa Loa (eye worm) hypothetical protein 0.0258 0.2048 0.3124
Onchocerca volvulus Cathepsin L homolog 0.0111 0.033 0.0418
Toxoplasma gondii dipeptidyl peptidase iv (dpp iv) n-terminal region domain-containing protein 0.0175 0.1073 0.1428
Leishmania major phosphatidylcholine:ceramide cholinephosphotransferase 2 0.0482 0.4662 1
Schistosoma mansoni hypothetical protein 0.0301 0.2543 0.3925
Schistosoma mansoni cathepsin D (A01 family) 0.0305 0.2597 0.4008
Echinococcus granulosus a disintegrin and metalloproteinase with 0.0087 0.0051 0.0017
Loa Loa (eye worm) hypothetical protein 0.0248 0.1924 0.2932
Plasmodium vivax metacaspase 1, putative 0.0248 0.1924 1
Schistosoma mansoni subfamily S9B unassigned peptidase (S09 family) 0.029 0.2415 0.3727
Schistosoma mansoni multidrug resistance protein 0.0107 0.0283 0.0437
Echinococcus granulosus adam 0.013 0.0554 0.0566
Loa Loa (eye worm) cysteine protease 0.0111 0.033 0.0458
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0164 0.0949 0.1464
Trypanosoma cruzi sphingomyelin/ceramide phosphorylethanolamine synthase, bifunctional 0.0482 0.4662 1
Trypanosoma brucei metacaspase 5, putative 0.0248 0.1924 0.368
Schistosoma mansoni SmCB2 peptidase (C01 family) 0.0164 0.0949 0.1464
Echinococcus multilocularis apoptotic protease activating factor 1 0.0247 0.1918 0.2052
Trichomonas vaginalis conserved hypothetical protein 0.0248 0.1924 1
Brugia malayi Hemopexin family protein 0.0301 0.2543 0.3877
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0111 0.033 0.0285
Loa Loa (eye worm) hypothetical protein 0.0107 0.0283 0.0385
Toxoplasma gondii cathepsin CPL 0.0111 0.033 0.0157
Echinococcus multilocularis Blood coagulation inhibitor, Disintegrin 0.019 0.1256 0.1331
Onchocerca volvulus 0.0247 0.1918 0.2892
Schistosoma mansoni caspase-3 (C14 family) 0.0393 0.3621 0.5589
Echinococcus granulosus cathepsin L cysteine proteinase 0.0111 0.033 0.0322
Schistosoma mansoni cathepsin F (C01 family) 0.0111 0.033 0.0509
Echinococcus multilocularis Dipeptidyl peptidase 9 0.0286 0.2372 0.2547
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0248 0.1924 1
Onchocerca volvulus 0.0111 0.033 0.0418
Onchocerca volvulus Cell death protein 3 homolog 0.0638 0.6479 1
Onchocerca volvulus Matrix metalloproteinase homolog 0.0499 0.4862 0.748
Leishmania major cathepsin L-like protease 0.0111 0.033 0.0107
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0115 0.0376 0.058
Leishmania major dipeptidyl-peptidase 8-like serine peptidase, putative,serine peptidase, Clan SC, Family S9B 0.0286 0.2372 0.477
Brugia malayi Cathepsin L-like precursor 0.0111 0.033 0.0434
Brugia malayi Cathepsin L-like precursor 0.0111 0.033 0.0434
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0221 0.1619 0.8843
Onchocerca volvulus Matrilysin homolog 0.0571 0.5702 0.8789
Echinococcus multilocularis multidrug resistance protein 1 0.0107 0.0283 0.0271
Onchocerca volvulus 0.0111 0.033 0.0418
Loa Loa (eye worm) hypothetical protein 0.0164 0.0949 0.1418
Brugia malayi cathepsin Z-like cysteine proteinase 0.0237 0.1799 0.272
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0248 0.1924 1
Loa Loa (eye worm) aspartic protease BmAsp-2 0.0115 0.0376 0.0529
Echinococcus multilocularis adam 17 protease 0.0184 0.1188 0.1256
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0111 0.033 0.0285
Trypanosoma cruzi metacaspase 5, putative 0.0248 0.1924 0.368
Schistosoma mansoni matrix metallopeptidase-7 (M10 family) 0.0313 0.2688 0.4148
Schistosoma mansoni subfamily M12B unassigned peptidase (M12 family) 0.0086 0.0035 0.0054
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0248 0.1924 1
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0164 0.0949 0.1464
Onchocerca volvulus 0.0111 0.033 0.0418
Echinococcus granulosus cathepsin b 0.0164 0.0949 0.0996
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0111 0.033 0.0285
Brugia malayi Cathepsin L-like precursor 0.0111 0.033 0.0434
Echinococcus granulosus cathepsin d lysosomal aspartyl protease 0.0115 0.0376 0.0372
Trypanosoma cruzi metacaspase 5, putative 0.0248 0.1924 0.368
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0111 0.033 0.0285
Brugia malayi mucosa associated lymphoid tissue lymphoma translocation protein 1 0.0248 0.1924 0.2914
Trichomonas vaginalis conserved hypothetical protein 0.0248 0.1924 1
Echinococcus multilocularis cysteine protease 0.0111 0.033 0.0322
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0237 0.1799 0.9239
Brugia malayi Cathepsin L-like precursor 0.0111 0.033 0.0434
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0248 0.1924 0.2884
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0248 0.1924 0.2884
Echinococcus multilocularis cathepsin b 0.0164 0.0949 0.0996
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0164 0.0949 0.1464
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0248 0.1924 1
Echinococcus multilocularis peptidyl glycine alpha amidating monooxygenase 0.046 0.4404 0.4762
Loa Loa (eye worm) fibroinase 0.0111 0.033 0.0458
Plasmodium falciparum metacaspase 1 0.0248 0.1924 1
Trypanosoma cruzi dipeptidyl-peptidase 8-like serine peptidase 0.0286 0.2372 0.4714
Onchocerca volvulus 0.0111 0.033 0.0418
Brugia malayi Matrixin family protein 0.0241 0.1848 0.2795
Echinococcus multilocularis a disintegrin and metalloproteinase with 0.0087 0.0051 0.0017
Brugia malayi hypothetical protein 0.0247 0.1918 0.2904
Brugia malayi Cathepsin L-like precursor 0.0111 0.033 0.0434
Brugia malayi Angiotensin-converting enzyme family protein 0.062 0.6267 0.967
Toxoplasma gondii cathepsin CPC1 0.0221 0.1619 0.2361
Loa Loa (eye worm) ctsf protein 0.0111 0.033 0.0458
Trypanosoma cruzi sphingomyelin/ceramide phosphorylethanolamine synthase, bifunctional 0.0482 0.4662 1
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0107 0.0283 0.0271
Trypanosoma brucei sphingomyelin/ceramide phosphorylethanolamine synthase, bifunctional 0.0482 0.4662 1
Trypanosoma brucei Dipeptidyl-peptidase 8-like, putative 0.0286 0.2372 0.4714
Plasmodium vivax dipeptidyl aminopeptidase 2, putative 0.0221 0.1619 0.8187
Onchocerca volvulus 0.0111 0.033 0.0418
Onchocerca volvulus 0.0111 0.033 0.0418
Plasmodium vivax aspartyl proteinase, putative 0.0115 0.0376 0.0816
Leishmania major cathepsin L-like protease 0.0111 0.033 0.0107
Echinococcus granulosus peptidyl glycine alpha amidating monooxygenase 0.046 0.4404 0.4762
Onchocerca volvulus 0.0111 0.033 0.0418
Schistosoma mansoni dipeptidyl-peptidase 9 (S09 family) 0.0286 0.2372 0.3661
Echinococcus granulosus caspase 3 0.0145 0.0731 0.0758
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0149 0.0775 0.2994
Toxoplasma gondii ATP-binding cassette transporter ABC.B1 0.0107 0.0283 0.0077
Plasmodium falciparum metacaspase-like protein 0.0248 0.1924 1
Onchocerca volvulus 0.0241 0.1848 0.2783
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0107 0.0283 0.0271
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0111 0.033 0.0322
Schistosoma mansoni smdr2 0.0107 0.0283 0.0437
Onchocerca volvulus 0.0107 0.0283 0.0345
Echinococcus granulosus multidrug resistance protein 1 0.0107 0.0283 0.0271
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0111 0.033 0.0545
Echinococcus multilocularis adam 0.013 0.0554 0.0566
Brugia malayi Matrixin family protein 0.0241 0.1848 0.2795
Echinococcus granulosus cathepsin b 0.0164 0.0949 0.0996
Brugia malayi Copper type II ascorbate-dependent monooxygenase, N-terminal domain containing protein 0.0124 0.0481 0.0669
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0248 0.1924 0.2884
Brugia malayi Matrix metalloprotease, N-terminal domain containing protein 0.0258 0.2048 0.3107
Leishmania major cathepsin L-like protease 0.0111 0.033 0.0107
Trypanosoma brucei metacaspase 0.0248 0.1924 0.368
Leishmania major metacaspase, putative 0.0248 0.1924 0.3748
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0248 0.1924 1
Toxoplasma gondii aspartyl protease ASP1 0.0115 0.0376 0.0235
Echinococcus granulosus multidrug resistance protein 1 0.0107 0.0283 0.0271
Echinococcus multilocularis dipeptidyl aminopeptidaseprotein 0.029 0.2415 0.2594
Echinococcus granulosus 5'partial|ATP binding cassette sub family B 0.0106 0.027 0.0256
Schistosoma mansoni subfamily C14A unassigned peptidase (C14 family) 0.0248 0.1924 0.297
Onchocerca volvulus Cathepsin F homolog 0.0111 0.033 0.0418
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0111 0.033 0.0285
Loa Loa (eye worm) matrix metalloproteinase 0.0241 0.1848 0.2813
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0248 0.1924 1
Onchocerca volvulus Matrilysin homolog 0.0241 0.1848 0.2783
Brugia malayi Matrixin family protein 0.0241 0.1848 0.2795
Chlamydia trachomatis ABC transporter ATP binding protein/permease 0.0107 0.0283 0.5
Giardia lamblia Cathepsin B precursor 0.0237 0.1799 1
Loa Loa (eye worm) hypothetical protein 0.0157 0.0872 0.1298
Echinococcus granulosus caspase 8 0.0248 0.1924 0.2059
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0111 0.033 0.0285
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0248 0.1924 1
Echinococcus granulosus cathepsin l cysteine peptidase 0.0111 0.033 0.0322
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0111 0.033 0.0285
Leishmania major cysteine peptidase A (CPA) 0.0111 0.033 0.0107
Plasmodium falciparum dipeptidyl aminopeptidase 2 0.0221 0.1619 0.8187
Plasmodium vivax hypothetical protein, conserved 0.0248 0.1924 1
Echinococcus multilocularis cysteine protease 0.0111 0.033 0.0322
Toxoplasma gondii preprocathepsin c precursor, putative 0.0221 0.1619 0.2361
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0237 0.1799 0.9239
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0107 0.0283 0.0271
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0107 0.0283 0.0271
Plasmodium falciparum plasmepsin VI 0.0115 0.0376 0.0816
Brugia malayi Trypsin family protein 0.0157 0.0872 0.1277
Onchocerca volvulus 0.0157 0.0872 0.1262
Echinococcus multilocularis matrix metallopeptidase 7 (M10 family) 0.0872 0.9211 1
Leishmania major cathepsin L-like protease 0.0111 0.033 0.0107
Trypanosoma brucei sphingomyelin/ceramide phosphorylethanolamine synthase, bifunctional 0.0482 0.4662 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0111 0.033 0.0285
Brugia malayi multidrug resistance protein 3 0.0107 0.0283 0.0362
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP 0.0107 0.0283 0.0271
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0111 0.033 0.0285
Loa Loa (eye worm) hypothetical protein 0.0462 0.443 0.682
Echinococcus multilocularis caspase 8 0.0248 0.1924 0.2059
Loa Loa (eye worm) prolyl oligopeptidase 0.029 0.2415 0.3693
Echinococcus multilocularis caspase 3 0.0145 0.0731 0.0758
Trichomonas vaginalis conserved hypothetical protein 0.0248 0.1924 1
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0111 0.033 0.0458
Schistosoma mansoni ADAM17 peptidase (M12 family) 0.0184 0.1188 0.1833
Echinococcus multilocularis cathepsin b 0.0164 0.0949 0.0996
Loa Loa (eye worm) hypothetical protein 0.0111 0.033 0.0458
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0248 0.1924 1
Echinococcus granulosus cathepsin l1 0.0111 0.033 0.0322
Echinococcus multilocularis cathepsin L cysteine protease 0.0111 0.033 0.0322
Leishmania major cathepsin L-like protease 0.0111 0.033 0.0107
Onchocerca volvulus Dipeptidyl peptidase family member 1 homolog 0.029 0.2415 0.3667
Trypanosoma cruzi metacaspase, putative 0.0248 0.1924 0.368
Echinococcus multilocularis multidrug resistance protein 1 0.0107 0.0283 0.0271
Trypanosoma brucei metacaspase MCA3 0.0248 0.1924 0.368
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0111 0.033 0.0285
Brugia malayi cathepsin B-like cysteine proteinase 0.0164 0.0949 0.1396
Echinococcus granulosus Dipeptidyl peptidase 9 0.0286 0.2372 0.2547
Loa Loa (eye worm) hypothetical protein 0.0241 0.1848 0.2813
Echinococcus granulosus disintegrin and metalloproteinase 0.0121 0.0449 0.0451
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0111 0.033 0.0322
Schistosoma mansoni memapsin-2 (A01 family) 0.0454 0.4337 0.6693
Echinococcus granulosus adam 17 protease 0.0244 0.1885 0.2017
Trypanosoma cruzi serine peptidase, Clan SC, Family S9B 0.0286 0.2372 0.4714
Trichomonas vaginalis conserved hypothetical protein 0.0248 0.1924 1
Schistosoma mansoni dihydroceramide desaturase 0.0121 0.0449 0.0693
Leishmania major cathepsin L-like protease 0.0111 0.033 0.0107
Plasmodium falciparum dipeptidyl aminopeptidase 1 0.0221 0.1619 0.8187
Trichomonas vaginalis conserved hypothetical protein 0.0248 0.1924 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0111 0.033 0.0285
Echinococcus granulosus apoptotic protease activating factor 1 0.0247 0.1918 0.2052
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0111 0.033 0.0458
Loa Loa (eye worm) hypothetical protein 0.0152 0.0813 0.1208
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0111 0.033 0.0285
Echinococcus multilocularis disintegrin and metalloproteinase 0.0121 0.0449 0.0451
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0111 0.033 0.0285
Loa Loa (eye worm) multidrug resistance protein 3 0.0107 0.0283 0.0385
Brugia malayi prolyl oligopeptidase family protein 0.0286 0.2372 0.361
Loa Loa (eye worm) hypothetical protein 0.0106 0.027 0.0364
Loa Loa (eye worm) hypothetical protein 0.0115 0.0376 0.0529
Echinococcus multilocularis cathepsin d (lysosomal aspartyl protease) 0.0115 0.0376 0.0372
Echinococcus multilocularis cathepsin L cysteine protease 0.0111 0.033 0.0322
Trichomonas vaginalis Clan AA, family A1, cathepsin D-like aspartic peptidase 0.0115 0.0376 0.0565
Schistosoma mansoni peptidylglycine monooxygenase 0.0244 0.1886 0.2911
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP 0.0107 0.0283 0.0271
Brugia malayi Matrixin family protein 0.0614 0.6197 0.9561
Toxoplasma gondii aspartyl proteinase (eimepsin), putative 0.0115 0.0376 0.0235
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0111 0.033 0.0545
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0111 0.033 0.0285
Mycobacterium ulcerans hydrolase 0.0258 0.2048 0.5
Brugia malayi Copper type II ascorbate-dependent monooxygenase, C-terminal domain containing protein 0.0244 0.1886 0.2855
Echinococcus multilocularis caspase 0.0393 0.3621 0.3908
Trypanosoma cruzi metacaspase, putative 0.0248 0.1924 0.368
Echinococcus granulosus multidrug resistance protein 1 0.0107 0.0283 0.0271
Toxoplasma gondii PAN domain-containing protein 0.0604 0.6085 1
Trypanosoma brucei metacaspase MCA2 0.0248 0.1924 0.368
Schistosoma mansoni peptidyl-glycine monooxygenase 0.046 0.4404 0.6797
Toxoplasma gondii PAN domain-containing protein 0.0604 0.6085 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0237 0.1799 0.9239
Plasmodium vivax plasmepsin IV, putative 0.0115 0.0376 0.0816
Schistosoma mansoni subfamily M12B unassigned peptidase (M12 family) 0.0086 0.0035 0.0054
Plasmodium falciparum plasmepsin IV 0.0115 0.0376 0.0816
Onchocerca volvulus 0.0301 0.2543 0.3866
Brugia malayi hypothetical protein 0.013 0.0554 0.0782
Schistosoma mansoni multidrug resistance protein 0.0107 0.0283 0.0437
Loa Loa (eye worm) hypothetical protein 0.0244 0.1886 0.2873
Loa Loa (eye worm) cysteine proteinase cathepsin Z 0.0237 0.1799 0.2738
Schistosoma mansoni cathepsin D (A01 family) 0.0305 0.2597 0.4008
Schistosoma mansoni dopamine-beta-monooxygenase 0.0244 0.1886 0.2911
Brugia malayi hypothetical protein 0.0133 0.0592 0.0842
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0164 0.0949 0.1428
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP 0.0107 0.0283 0.0271
Plasmodium falciparum plasmepsin II 0.0115 0.0376 0.0816
Brugia malayi Matrixin family protein 0.0241 0.1848 0.2795
Entamoeba histolytica cysteine proteinase, putative 0.0111 0.033 0.0048
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0157 0.0872 0.1345
Schistosoma mansoni dipeptidyl-peptidase I (C01 family) 0.0221 0.1619 0.2498
Loa Loa (eye worm) matrixin family protein 0.0614 0.6197 0.9562
Plasmodium vivax vivapain-2 0.0111 0.033 0.0545

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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