TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 410.489 | Formula: C21H22N4O3S
H donors: 1 H acceptors: 2 LogP: 3.61 Rotable bonds: 8
Rule of 5 violations (Lipinski): 1
SMILES: CCCOc1ccc(cc1)CNC(=O)Cn1ncn2c(c1=O)cc1c2cc(s1)C
InChi: 1S/C21H22N4O3S/c1-3-8-28-16-6-4-15(5-7-16)11-22-20(26)12-25-21(27)18-10-19-17(9-14(2)29-19)24(18)13-23-25/h4-7,9-10,13H,3,8,11-12H2,1-2H3,(H,22,26)
InChiKey: LASHKRQKKBKBIZ-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Plasmodium vivax	serine-repeat antigen 3 (SERA)	0.0131	0.0719	0.2722
Echinococcus granulosus	cathepsin l1	0.0383	0.2455	0.2448
Brugia malayi	cathepsin L-like cysteine proteinase	0.0131	0.0719	0.0684
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0383	0.2455	0.6891
Schistosoma mansoni	family C2 unassigned peptidase (C02 family)	0.0043	0.0111	0.0059
Trypanosoma cruzi	cysteine protease, putative	0.0146	0.0821	0.077
Trypanosoma cruzi	PAB1-binding protein , putative	0.005	0.016	0.0092
Brugia malayi	Papain family cysteine protease containing protein	0.0131	0.0719	0.0684
Echinococcus multilocularis	cysteine protease	0.0383	0.2455	0.2477
Echinococcus multilocularis	tumor protein p63	0.0342	0.2171	0.2187
Loa Loa (eye worm)	matrixin family protein	0.0095	0.0469	0.0469
Mycobacterium leprae	PROBABLE HYDROLASE	0.0052	0.0175	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L, S or H-like cysteine peptidase	0.0131	0.0719	0.1876
Onchocerca volvulus	Cathepsin L homolog	0.0383	0.2455	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0146	0.0821	0.2168
Plasmodium falciparum	dipeptidyl aminopeptidase 3	0.0131	0.0719	0.2439
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0383	0.2455	0.6891
Entamoeba histolytica	cysteine protease, putative	0.0146	0.0821	0.0583
Loa Loa (eye worm)	hypothetical protein	0.1451	0.9809	0.9809
Trypanosoma cruzi	cysteine peptidase, putative	0.0383	0.2455	0.2448
Trichomonas vaginalis	Clan CA, family C1, cathepsin H-like cysteine peptidase	0.0131	0.0719	0.1876
Brugia malayi	Cathepsin L-like precursor	0.0383	0.2455	0.2426
Toxoplasma gondii	cathepsin B	0.0539	0.3531	1
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0092	0.0449	0.0389
Brugia malayi	Cathepsin L-like precursor	0.0383	0.2455	0.2426
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0383	0.2455	0.6891
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0092	0.0449	0.0405
Echinococcus multilocularis	cathepsin b	0.1451	0.9809	1
Plasmodium falciparum	serine repeat antigen 1	0.0131	0.0719	0.2439
Trypanosoma cruzi	cruzipain precursor, putative	0.0383	0.2455	0.2448
Entamoeba histolytica	cysteine proteinase, putative	0.0383	0.2455	1
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0146	0.0821	0.0786
Brugia malayi	cahepsin L-like non-peptiedase homolog	0.0131	0.0719	0.0684
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0131	0.0719	0.0682
Trypanosoma cruzi	cysteine peptidase, putative	0.0383	0.2455	0.2448
Loa Loa (eye worm)	beta-LACTamase domain containing family member	0.0037	0.007	0.007
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0383	0.2455	0.6891
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0131	0.0719	0.1876
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0383	0.2455	0.6891
Leishmania major	cathepsin L-like protease	0.0383	0.2455	0.6891
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0092	0.0449	0.0405
Entamoeba histolytica	cysteine proteinase 2	0.0146	0.0821	0.0583
Plasmodium falciparum	serine repeat antigen 5	0.0131	0.0719	0.2439
Entamoeba histolytica	cysteine proteinase, putative	0.0146	0.0821	0.0583
Loa Loa (eye worm)	cathepsin B	0.0539	0.3531	0.3531
Loa Loa (eye worm)	hypothetical protein	0.0368	0.2353	0.2353
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0383	0.2455	0.6891
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0131	0.0719	0.1876
Trypanosoma brucei	PAB1-binding protein , putative	0.005	0.016	0.0258
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0383	0.2455	0.6891
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.1451	0.9809	1
Mycobacterium tuberculosis	Possible penicillin-binding protein	0.0236	0.1439	1
Echinococcus granulosus	cathepsin L	0.0146	0.0821	0.077
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0092	0.0449	0.0425
Loa Loa (eye worm)	matrix metalloproteinase	0.0043	0.011	0.011
Onchocerca volvulus		0.005	0.0161	0.0655
Echinococcus multilocularis	beta LACTamase domain containing family member	0.0037	0.007	0.0038
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0383	0.2455	0.6891
Toxoplasma gondii	cathepsin CPC1	0.0131	0.0719	0.1876
Plasmodium falciparum	dipeptidyl aminopeptidase 1	0.0131	0.0719	0.2439
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0146	0.0821	0.2168
Brugia malayi	cathepsin B-like cysteine proteinase	0.1451	0.9809	0.9809
Loa Loa (eye worm)	hypothetical protein	0.0043	0.0111	0.0111
Plasmodium vivax	dipeptidyl aminopeptidase 1, putative	0.0131	0.0719	0.2722
Trypanosoma cruzi	cysteine proteinase, putative	0.0146	0.0821	0.077
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0131	0.0719	0.0719
Plasmodium vivax	dipeptidyl aminopeptidase 3, putative	0.0131	0.0719	0.2722
Brugia malayi	Matrixin family protein	0.0043	0.011	0.0073
Loa Loa (eye worm)	hypothetical protein	0.0052	0.0175	0.0175
Onchocerca volvulus		0.0383	0.2455	1
Entamoeba histolytica	cysteine proteinase, putative	0.0383	0.2455	1
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0131	0.0719	0.0682
Schistosoma mansoni	hypothetical protein	0.0174	0.1012	0.0982
Trypanosoma brucei	cysteine peptidase C (CPC)	0.0539	0.3531	1
Echinococcus granulosus	tumor protein p63	0.0342	0.2171	0.2157
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0383	0.2455	0.6891
Plasmodium falciparum	cysteine proteinase falcipain 1	0.0146	0.0821	0.288
Plasmodium vivax	dipeptidyl aminopeptidase 2, putative	0.0131	0.0719	0.2722
Trypanosoma cruzi	cysteine peptidase, putative	0.0146	0.0821	0.077
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	0.1451	0.9809	1
Toxoplasma gondii	cathepsin CPL	0.0383	0.2455	0.6891
Echinococcus granulosus	cathepsin L cysteine protease	0.0146	0.0821	0.077
Trichomonas vaginalis	Clan CA, family C1, cathepsin F-like cysteine peptidase	0.0131	0.0719	0.1876
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0037	0.007	0.0017
Loa Loa (eye worm)	hypothetical protein	0.0043	0.011	0.011
Leishmania major	cathepsin L-like protease	0.0383	0.2455	0.6891
Schistosoma mansoni	cathepsin F (C01 family)	0.0383	0.2455	0.2461
Loa Loa (eye worm)	hypothetical protein	0.0043	0.011	0.011
Schistosoma mansoni	hypothetical protein	0.0061	0.0233	0.0184
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.1451	0.9809	1
Loa Loa (eye worm)	calpain family protein 1	0.0032	0.0033	0.0033
Onchocerca volvulus	Matrilysin homolog	0.0043	0.011	0.045
Onchocerca volvulus	Cathepsin F homolog	0.0383	0.2455	1
Onchocerca volvulus		0.0383	0.2455	1
Brugia malayi	Papain family cysteine protease containing protein	0.0131	0.0719	0.0684
Echinococcus multilocularis	geminin	0.0174	0.1012	0.1001
Plasmodium falciparum	serine repeat antigen 7	0.0131	0.0719	0.2439
Echinococcus granulosus	cathepsin L cysteine proteinase	0.0383	0.2455	0.2448
Brugia malayi	hypothetical protein	0.005	0.016	0.0122
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.0131	0.0719	0.1876
Giardia lamblia	Cathepsin B precursor	0.0539	0.3531	1
Echinococcus granulosus	cysteine protease	0.0146	0.0821	0.077
Brugia malayi	Papain family cysteine protease containing protein	0.0131	0.0719	0.0684
Leishmania major	cathepsin L-like protease	0.0383	0.2455	0.6891
Trypanosoma cruzi	cysteine peptidase, putative	0.0383	0.2455	0.2448
Schistosoma mansoni	subfamily C1A non-peptidase homologue (C01 family)	0.0131	0.0719	0.0682
Schistosoma mansoni	cathepsin F (C01 family)	0.0383	0.2455	0.2461
Entamoeba histolytica	cysteine protease, putative	0.0146	0.0821	0.0583
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0383	0.2455	0.6891
Brugia malayi	Matrixin family protein	0.0103	0.0528	0.0492
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.0131	0.0719	0.1876
Trypanosoma cruzi	cysteine peptidase, putative	0.0383	0.2455	0.2448
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0383	0.2455	0.2477
Echinococcus multilocularis	cathepsin L cysteine protease	0.0383	0.2455	0.2477
Onchocerca volvulus		0.0383	0.2455	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0383	0.2455	0.6891
Loa Loa (eye worm)	hypothetical protein	0.0383	0.2455	0.2455
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0383	0.2455	0.6891
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0383	0.2455	0.6891
Plasmodium falciparum	serine repeat antigen 2	0.0131	0.0719	0.2439
Loa Loa (eye worm)	hypothetical protein	0.0131	0.0719	0.0719
Leishmania major	cathepsin L-like protease	0.0383	0.2455	0.6891
Onchocerca volvulus		0.0131	0.0719	0.293
Plasmodium falciparum	dipeptidyl aminopeptidase 2	0.0131	0.0719	0.2439
Brugia malayi	latrophilin 2 splice variant baaae	0.0034	0.0054	0.0016
Brugia malayi	cathepsin Z-like cysteine proteinase	0.0131	0.0719	0.0684
Loa Loa (eye worm)	MH2 domain-containing protein	0.0122	0.0659	0.0659
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.005	0.0164	0.0126
Entamoeba histolytica	cysteine protease, putative	0.0383	0.2455	1
Brugia malayi	Papain family cysteine protease containing protein	0.0146	0.0821	0.0786
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0037	0.007	0.0017
Plasmodium vivax	unspecified product	0.0131	0.0719	0.2722
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0383	0.2455	0.6891
Leishmania major	hypothetical protein, conserved	0.005	0.016	0.0258
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0383	0.2455	0.6891
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0033	0.0033
Toxoplasma gondii	cathepsin CPC2	0.0131	0.0719	0.1876
Brugia malayi	cathepsin Z-like cysteine proteinase	0.0131	0.0719	0.0684
Leishmania major	cathepsin L-like protease	0.0383	0.2455	0.6891
Brugia malayi	Hemopexin family protein	0.0061	0.0233	0.0196
Trypanosoma cruzi	cysteine peptidase, clan CA, family C1, cathepsin L-like, putative	0.0368	0.2353	0.2344
Entamoeba histolytica	cysteine proteinase, putative	0.0368	0.2353	0.9417
Plasmodium vivax	serine-repeat antigen 4 (SERA), putative	0.0131	0.0719	0.2722
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0383	0.2455	0.6891
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0383	0.2455	0.6891
Echinococcus granulosus	integrin beta 2	0.1083	0.7272	0.7395
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0383	0.2455	0.6891
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0383	0.2455	0.6891
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0131	0.0719	0.1876
Schistosoma mansoni	cathepsin C	0.0131	0.0719	0.0682
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0383	0.2455	0.6891
Loa Loa (eye worm)	Papain cysteine protease/cathepsin propeptide inhibitor-containing protein	0.0383	0.2455	0.2455
Trypanosoma cruzi	cysteine proteinase, putative	0.0146	0.0821	0.077
Plasmodium vivax	serine-repeat antigen (SERA)	0.0131	0.0719	0.2722
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0092	0.0449	0.0405
Brugia malayi	Cathepsin L-like precursor	0.0368	0.2353	0.2324
Brugia malayi	cathepsin L-like precursor	0.0368	0.2353	0.2324
Plasmodium vivax	serine-repeat antigen (SERA)	0.0131	0.0719	0.2722
Plasmodium vivax	serine-repeat antigen (SERA), putative	0.0131	0.0719	0.2722
Plasmodium falciparum	serine repeat antigen 9	0.0131	0.0719	0.2439
Leishmania major	cathepsin L-like protease	0.0383	0.2455	0.6891
Brugia malayi	beta-lactamase family protein	0.0037	0.007	0.0032
Entamoeba histolytica	cysteine protease, putative	0.0146	0.0821	0.0583
Echinococcus multilocularis	cathepsin L	0.0146	0.0821	0.0805
Onchocerca volvulus		0.0037	0.007	0.0286
Loa Loa (eye worm)	kelch domain-containing protein family protein	0.0232	0.1415	0.1415
Plasmodium falciparum	serine repeat antigen 8	0.0131	0.0719	0.2439
Echinococcus multilocularis	matrix metallopeptidase 7 (M10 family)	0.0155	0.0886	0.0872
Echinococcus granulosus	cathepsin l1	0.0368	0.2353	0.2344
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0092	0.0449	0.0413
Onchocerca volvulus	Matrix metalloproteinase homolog	0.0095	0.0469	0.191
Trypanosoma cruzi	major cysteine proteinase, putative	0.0131	0.0719	0.0666
Entamoeba histolytica	cysteine proteinase, putative	0.0146	0.0821	0.0583
Entamoeba histolytica	cysteine proteinase 1, putative	0.0146	0.0821	0.0583
Brugia malayi	fibroinase precursor	0.0131	0.0719	0.0684
Plasmodium vivax	vivapain-3	0.0146	0.0821	0.3147
Brugia malayi	Papain family cysteine protease containing protein	0.0146	0.0821	0.0786
Plasmodium vivax	serine-repeat antigen (SERA), putative	0.0131	0.0719	0.2722
Leishmania major	cathepsin L-like protease	0.0383	0.2455	0.6891
Loa Loa (eye worm)	integrin beta-2	0.1479	1	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0383	0.2455	0.6891
Onchocerca volvulus		0.0061	0.0233	0.0951
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0078	0.0078
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.1451	0.9809	1
Brugia malayi	Cathepsin L-like precursor	0.0383	0.2455	0.2426
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0383	0.2455	0.6891
Plasmodium vivax	serine-repeat antigen 4 (SERA)	0.0131	0.0719	0.2722
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0383	0.2455	0.6891
Loa Loa (eye worm)	hypothetical protein	0.005	0.016	0.016
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0131	0.0719	0.1876
Loa Loa (eye worm)	hypothetical protein	0.0037	0.007	0.007
Loa Loa (eye worm)	hypothetical protein	0.0368	0.2353	0.2353
Echinococcus granulosus	matrix metallopeptidase 7 M10 family	0.0155	0.0886	0.0838
Entamoeba histolytica	cysteine protease, putative	0.0146	0.0821	0.0583
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0131	0.0719	0.1876
Leishmania major	cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like	0.0539	0.3531	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0146	0.0821	0.2168
Echinococcus multilocularis	calpain A	0.0045	0.0125	0.0093
Brugia malayi	Kelch motif family protein	0.0232	0.1415	0.1382
Loa Loa (eye worm)	hypothetical protein	0.0037	0.007	0.007
Echinococcus multilocularis	integrin beta 2	0.1083	0.7272	0.7405
Leishmania major	cysteine peptidase A (CPA)	0.0383	0.2455	0.6891
Echinococcus multilocularis	cysteine protease	0.0383	0.2455	0.2477
Brugia malayi	Cathepsin L-like precursor	0.0368	0.2353	0.2324
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0131	0.0719	0.0682
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0146	0.0821	0.2168
Entamoeba histolytica	cysteine protease, putative	0.0146	0.0821	0.0583
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0092	0.0449	0.0425
Brugia malayi	calpain family protein 1	0.0043	0.0111	0.0074
Echinococcus multilocularis	cathepsin L cysteine protease	0.0383	0.2455	0.2477
Entamoeba histolytica	cysteine proteinase, putative	0.0146	0.0821	0.0583
Plasmodium vivax	unspecified product	0.0146	0.0821	0.3147
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0131	0.0719	0.0682
Loa Loa (eye worm)	cysteine proteinase cathepsin Z	0.0131	0.0719	0.0719
Onchocerca volvulus	Cathepsin L homolog	0.0131	0.0719	0.293
Schistosoma mansoni	hypothetical protein	0.0174	0.1012	0.0982
Entamoeba histolytica	cysteine protease, putative	0.0146	0.0821	0.0583
Onchocerca volvulus		0.0383	0.2455	1
Loa Loa (eye worm)	hypothetical protein	0.0037	0.007	0.007
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.0131	0.0719	0.1876
Echinococcus granulosus	cathepsin l cysteine peptidase	0.0383	0.2455	0.2448
Echinococcus multilocularis	cathepsin b	0.1451	0.9809	1
Onchocerca volvulus		0.0383	0.2455	1
Loa Loa (eye worm)	hypothetical protein	0.0368	0.2353	0.2353
Schistosoma mansoni	cathepsin B (C01 family)	0.0131	0.0719	0.0682
Giardia lamblia	Cathepsin B precursor	0.0539	0.3531	1
Schistosoma mansoni	subfamily C1A unassigned peptidase (C01 family)	0.0131	0.0719	0.0682
Brugia malayi	Cathepsin L-like precursor	0.0383	0.2455	0.2426
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0383	0.2455	0.6891
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0383	0.2455	0.6891
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.0539	0.3531	1
Loa Loa (eye worm)	calpain family protein 1	0.0043	0.0111	0.0111
Onchocerca volvulus		0.0037	0.007	0.0286
Toxoplasma gondii	LsmAD domain-containing protein	0.005	0.016	0.0258
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0054	0.0054
Schistosoma mansoni	subfamily C1A unassigned peptidase (C01 family)	0.0131	0.0719	0.0682
Entamoeba histolytica	cysteine protease, putative	0.0146	0.0821	0.0583
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0131	0.0719	0.1876
Schistosoma mansoni	SmCB2 peptidase (C01 family)	0.1451	0.9809	1
Loa Loa (eye worm)	hypothetical protein	0.0037	0.007	0.007
Brugia malayi	Matrixin family protein	0.0043	0.011	0.0073
Entamoeba histolytica	cysteine proteinase, putative	0.0146	0.0821	0.0583
Brugia malayi	calpain family protein 1	0.0043	0.0111	0.0074
Onchocerca volvulus		0.0037	0.007	0.0286
Plasmodium falciparum	cysteine proteinase falcipain 2a	0.0383	0.2455	1
Echinococcus granulosus	calpain A	0.0045	0.0125	0.0056
Plasmodium falciparum	serine repeat antigen 4	0.0131	0.0719	0.2439
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0383	0.2455	0.6891
Loa Loa (eye worm)	hypothetical protein	0.0131	0.0719	0.0719
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or H-like cysteine peptidase	0.0131	0.0719	0.1876
Trypanosoma cruzi	major cysteine proteinase, putative	0.0131	0.0719	0.0666
Trypanosoma cruzi	PAB1-binding protein , putative	0.005	0.016	0.0092
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.0131	0.0719	0.1876
Plasmodium falciparum	serine repeat antigen 3	0.0131	0.0719	0.2439
Echinococcus multilocularis	cathepsin L	0.0131	0.0719	0.0702
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0383	0.2455	0.2477
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0383	0.2455	0.6891
Plasmodium falciparum	cysteine proteinase falcipain 3	0.0383	0.2455	1
Plasmodium vivax	ataxin-2 like protein, putative	0.005	0.016	0.0375
Brugia malayi	Matrixin family protein	0.0043	0.011	0.0073
Loa Loa (eye worm)	hypothetical protein	0.0232	0.1415	0.1415
Brugia malayi	Papain family cysteine protease containing protein	0.0383	0.2455	0.2426
Plasmodium falciparum	serine repeat antigen 6	0.0131	0.0719	0.2439
Mycobacterium tuberculosis	Probable peptidoglycan hydrolase	0.0052	0.0175	0.0762
Plasmodium vivax	vivapain-2	0.0383	0.2455	1
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.005	0.0164	0.0164
Loa Loa (eye worm)	matrixin family protein	0.0103	0.0528	0.0528
Onchocerca volvulus	Matrilysin homolog	0.0095	0.0469	0.191
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0131	0.0719	0.0719
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0131	0.0719	0.1876
Onchocerca volvulus		0.0368	0.2353	0.9588
Entamoeba histolytica	cysteine protease, putative	0.0146	0.0821	0.0583
Brugia malayi	Cathepsin L-like precursor	0.0383	0.2455	0.2426
Schistosoma mansoni	cellular tumor antigen P53	0.005	0.0161	0.011
Loa Loa (eye worm)	beta-lactamase	0.0037	0.007	0.007
Brugia malayi	Calcitonin receptor-like protein seb-1	0.005	0.0164	0.0126
Trichomonas vaginalis	conserved hypothetical protein	0.0131	0.0719	0.1876
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0368	0.2353	0.6598
Loa Loa (eye worm)	ctsf protein	0.0383	0.2455	0.2455
Plasmodium vivax	vivapain-2	0.0383	0.2455	1
Brugia malayi	Matrixin family protein	0.0043	0.011	0.0073
Plasmodium vivax	serine-repeat antigen 5 (SERA)	0.0131	0.0719	0.2722
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0092	0.0449	0.0389
Brugia malayi	Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative	0.0037	0.007	0.0032
Brugia malayi	cathepsin F-like cysteine proteinase	0.0131	0.0719	0.0684
Onchocerca volvulus		0.0043	0.011	0.045
Onchocerca volvulus		0.0383	0.2455	1
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0131	0.0719	0.0682
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0383	0.2455	0.6891
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0383	0.2455	0.6891
Brugia malayi	cathepsin L precursor	0.0131	0.0719	0.0684
Plasmodium vivax	vivapain-1	0.0146	0.0821	0.3147
Brugia malayi	Matrix metalloprotease, N-terminal domain containing protein	0.0052	0.0175	0.0137
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0383	0.2455	0.6891
Brugia malayi	beta-lactamase	0.0037	0.007	0.0032
Brugia malayi	Cathepsin L-like cysteine proteinase	0.0368	0.2353	0.2324
Schistosoma mansoni	family C2 unassigned peptidase (C02 family)	0.0045	0.0125	0.0073
Plasmodium vivax	serine-repeat antigen 2 (SERA)	0.0131	0.0719	0.2722
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0383	0.2455	0.6891
Loa Loa (eye worm)	hypothetical protein	0.0131	0.0719	0.0719
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	0.0539	0.3531	0.3553
Loa Loa (eye worm)	hypothetical protein	0.0037	0.007	0.007
Toxoplasma gondii	preprocathepsin c precursor, putative	0.0131	0.0719	0.1876
Entamoeba histolytica	cysteine protease, putative	0.0146	0.0821	0.0583
Loa Loa (eye worm)	hypothetical protein	0.0131	0.0719	0.0719
Loa Loa (eye worm)	hypothetical protein	0.0131	0.0719	0.0719
Echinococcus granulosus	cathepsin b	0.1451	0.9809	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0131	0.0719	0.1876
Brugia malayi	hypothetical protein	0.0232	0.1415	0.1382
Echinococcus granulosus	family C2 unassigned peptidase C02 family	0.0045	0.0125	0.0056
Echinococcus granulosus	cathepsin b	0.1451	0.9809	1
Brugia malayi	MH2 domain containing protein	0.0122	0.0659	0.0623
Loa Loa (eye worm)	cysteine protease	0.0383	0.2455	0.2455
Leishmania major	cathepsin L-like protease	0.0383	0.2455	0.6891
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0383	0.2455	0.6891
Brugia malayi	Cathepsin L-like precursor	0.0383	0.2455	0.2426
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0146	0.0821	0.0786
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0383	0.2455	0.6891
Loa Loa (eye worm)	hypothetical protein	0.005	0.0164	0.0164
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0539	0.3531	0.3564
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0383	0.2455	0.6891
Schistosoma mansoni	family C2 unassigned peptidase (C02 family)	0.0045	0.0125	0.0073
Schistosoma mansoni	integrin beta subunit	0.0851	0.5674	0.5761
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0368	0.2353	0.6598
Loa Loa (eye worm)	hypothetical protein	0.0131	0.0719	0.0719
Loa Loa (eye worm)	hypothetical protein	0.0037	0.007	0.007
Schistosoma mansoni	dipeptidyl-peptidase I (C01 family)	0.0131	0.0719	0.0682
Echinococcus granulosus	geminin	0.0174	0.1012	0.0967
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0131	0.0719	0.1876
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0092	0.0449	0.0449
Giardia lamblia	Cathepsin B precursor	0.0539	0.3531	1
Trichomonas vaginalis	conserved hypothetical protein	0.0131	0.0719	0.1876
Plasmodium falciparum	cysteine proteinase falcipain 2b	0.0383	0.2455	1
Mycobacterium ulcerans	hydrolase	0.0052	0.0175	1
Echinococcus granulosus	cathepsin L	0.0131	0.0719	0.0666
Onchocerca volvulus	Cathepsin L homolog	0.0383	0.2455	1
Entamoeba histolytica	cysteine protease, putative	0.0146	0.0821	0.0583
Entamoeba histolytica	cysteine protease, putative	0.0146	0.0821	0.0583
Brugia malayi	beta-lactamase family protein	0.0037	0.007	0.0032
Loa Loa (eye worm)	fibroinase	0.0383	0.2455	0.2455
Schistosoma mansoni	cathepsin S (C01 family)	0.0131	0.0719	0.0682
Entamoeba histolytica	cysteine protease, putative	0.0146	0.0821	0.0583
Loa Loa (eye worm)	hypothetical protein	0.005	0.0161	0.0161
Loa Loa (eye worm)	hypothetical protein	0.0043	0.011	0.011
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0383	0.2455	0.6891
Loa Loa (eye worm)	transcription factor SMAD2	0.0122	0.0659	0.0659
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0383	0.2455	0.2455
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0383	0.2455	0.6891
Trypanosoma cruzi	cysteine peptidase (N-terminal), putative	0.0146	0.0821	0.077
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0146	0.0821	0.0786
Onchocerca volvulus		0.0383	0.2455	1
Entamoeba histolytica	cysteine protease, putative	0.0146	0.0821	0.0583
Schistosoma mansoni	matrix metallopeptidase-7 (M10 family)	0.0043	0.011	0.0058
Schistosoma mansoni	cathepsin F (C01 family)	0.0368	0.2353	0.2357
Echinococcus multilocularis	family C2 unassigned peptidase (C02 family)	0.0045	0.0125	0.0093

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

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Bibliographic References

No literature references available for this target.

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Detailed information for compound 832468