Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | carboxylesterase 5A | 0.0066 | 0.0551 | 0.1425 |
Plasmodium falciparum | 3-oxo-5-alpha-steroid 4-dehydrogenase, putative | 0.0154 | 0.1639 | 0.5 |
Mycobacterium ulcerans | hypothetical protein | 0.0824 | 1 | 1 |
Mycobacterium leprae | PROBABLE CHOLESTEROL DEHYDROGENASE | 0.0022 | 0 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0154 | 0.1639 | 0.1639 |
Echinococcus multilocularis | carboxylesterase 5A | 0.0066 | 0.0551 | 0.1425 |
Trichomonas vaginalis | 3-oxo-5-alpha-steroid 4-dehydrogenase, putative | 0.0154 | 0.1639 | 0.1639 |
Trypanosoma brucei | C-14 sterol reductase, putative | 0.0052 | 0.0371 | 0.0371 |
Plasmodium vivax | polyprenol reductase, putative | 0.0154 | 0.1639 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0505 | 0.6026 | 0.6026 |
Plasmodium falciparum | polyprenol reductase, putative | 0.0154 | 0.1639 | 0.5 |
Brugia malayi | Carboxylesterase family protein | 0.0066 | 0.0551 | 0.0551 |
Schistosoma mansoni | synaptic glycoprotein sc2 related | 0.0154 | 0.1639 | 1 |
Leishmania major | C-14 sterol reductase, putative | 0.0052 | 0.0371 | 0.0371 |
Trichomonas vaginalis | 3-oxo-5-alpha-steroid 4-dehydrogenase, putative | 0.0824 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0154 | 0.1639 | 0.1639 |
Leishmania major | sterol C-24 reductase, putative | 0.0052 | 0.0371 | 0.0371 |
Echinococcus granulosus | synaptic glycoprotein sc2 | 0.0154 | 0.1639 | 1 |
Trypanosoma cruzi | 3-oxo-5-alpha-steroid 4-dehydrogenase, putative | 0.0154 | 0.1639 | 0.1639 |
Trypanosoma cruzi | sterol C-24 reductase, putative | 0.0052 | 0.0371 | 0.0371 |
Echinococcus granulosus | 3 oxo 5 alpha steroid 4 dehydrogenase C terminal | 0.0154 | 0.1639 | 1 |
Echinococcus multilocularis | synaptic glycoprotein sc2 | 0.0154 | 0.1639 | 1 |
Giardia lamblia | Synaptic glycoprotein SC2 | 0.0154 | 0.1639 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0824 | 1 | 1 |
Trypanosoma cruzi | sterol C-24 reductase, putative | 0.0052 | 0.0371 | 0.0371 |
Loa Loa (eye worm) | hypothetical protein | 0.0154 | 0.1639 | 0.1639 |
Echinococcus multilocularis | acetylcholinesterase | 0.0066 | 0.0551 | 0.1425 |
Trypanosoma brucei | 3-oxo-5-alpha-steroid 4-dehydrogenase, putative | 0.0154 | 0.1639 | 0.1639 |
Mycobacterium tuberculosis | 3-beta-hydroxysteroid dehydrogenase | 0.0022 | 0 | 0.5 |
Echinococcus multilocularis | 3 oxo 5 alpha steroid 4 dehydrogenase, C terminal | 0.0154 | 0.1639 | 1 |
Trichomonas vaginalis | 3-oxo-5-alpha-steroid 4-dehydrogenase, putative | 0.0824 | 1 | 1 |
Trypanosoma cruzi | 3-oxo-5-alpha-steroid 4-dehydrogenase, putative | 0.0824 | 1 | 1 |
Entamoeba histolytica | steroid 5-alpha reductase, putative | 0.0824 | 1 | 1 |
Trypanosoma cruzi | C-14 sterol reductase, putative | 0.0052 | 0.0371 | 0.0371 |
Trypanosoma cruzi | 3-oxo-5-alpha-steroid 4-dehydrogenase, putative | 0.0824 | 1 | 1 |
Leishmania major | 3-oxo-5-alpha-steroid 4-dehydrogenase-like protein | 0.0824 | 1 | 1 |
Echinococcus granulosus | acetylcholinesterase | 0.0066 | 0.0551 | 0.1425 |
Plasmodium vivax | 3-oxo-5-alpha-steroid 4-dehydrogenase, putative | 0.0154 | 0.1639 | 0.5 |
Trichomonas vaginalis | synaptic glycoprotein sc2, putative | 0.0154 | 0.1639 | 0.1639 |
Brugia malayi | Synaptic glycoprotein SC2 | 0.0154 | 0.1639 | 0.1639 |
Loa Loa (eye worm) | hypothetical protein | 0.0066 | 0.0551 | 0.0551 |
Loa Loa (eye worm) | hypothetical protein | 0.0066 | 0.0551 | 0.0551 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0154 | 0.1639 | 0.1639 |
Trichomonas vaginalis | synaptic glycoprotein sc2, putative | 0.0154 | 0.1639 | 0.1639 |
Schistosoma mansoni | synaptic glycoprotein sc2 related | 0.0154 | 0.1639 | 1 |
Trypanosoma cruzi | C-14 sterol reductase, putative | 0.0052 | 0.0371 | 0.0371 |
Echinococcus multilocularis | acetylcholinesterase | 0.0066 | 0.0551 | 0.1425 |
Toxoplasma gondii | 3-oxo-5-alpha-steroid 4-dehydrogenase | 0.0824 | 1 | 1 |
Trichomonas vaginalis | 3-oxo-5-alpha-steroid 4-dehydrogenase, putative | 0.0824 | 1 | 1 |
Loa Loa (eye worm) | carboxylesterase | 0.0066 | 0.0551 | 0.0551 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0066 | 0.0551 | 0.1425 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.0066 | 0.0551 | 0.0551 |
Trichomonas vaginalis | synaptic glycoprotein sc2, putative | 0.0154 | 0.1639 | 0.1639 |
Echinococcus granulosus | acetylcholinesterase | 0.0066 | 0.0551 | 0.1425 |
Trypanosoma brucei | 3-oxo-5-alpha-steroid 4-dehydrogenase-like, putative | 0.0824 | 1 | 1 |
Onchocerca volvulus | 0.0154 | 0.1639 | 1 | |
Brugia malayi | Carboxylesterase family protein | 0.0066 | 0.0551 | 0.0551 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.