Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0031 | 0.0339 | 0.0344 |
Trypanosoma cruzi | tyrosyl-DNA Phosphodiesterase (Tdp1), putative | 0.0068 | 0.1134 | 1 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0037 | 0.0474 | 0.0658 |
Echinococcus multilocularis | lamin dm0 | 0.0028 | 0.0275 | 0.0173 |
Trypanosoma cruzi | tyrosyl-DNA Phosphodiesterase (Tdp1), putative | 0.0068 | 0.1134 | 1 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0037 | 0.0474 | 0.0371 |
Onchocerca volvulus | 0.0242 | 0.4892 | 1 | |
Brugia malayi | glutaminase DH11.1 | 0.028 | 0.5695 | 0.579 |
Mycobacterium tuberculosis | Possible conserved lipoprotein LpqK | 0.0037 | 0.0474 | 0.0793 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0037 | 0.0474 | 0.3576 |
Toxoplasma gondii | ABC1 family protein | 0.0037 | 0.0474 | 1 |
Mycobacterium tuberculosis | Probable esterase LipL | 0.0037 | 0.0474 | 0.0793 |
Schistosoma mansoni | histone-lysine n-methyltransferase suv9 | 0.0031 | 0.0339 | 0.0235 |
Loa Loa (eye worm) | beta-LACTamase domain containing family member | 0.0037 | 0.0474 | 0.0482 |
Echinococcus granulosus | transcription factor Dp 1 | 0.0039 | 0.0523 | 0.0428 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0031 | 0.0339 | 0.0235 |
Loa Loa (eye worm) | intermediate filament tail domain-containing protein | 0.0028 | 0.0275 | 0.028 |
Onchocerca volvulus | 0.0037 | 0.0474 | 0.0431 | |
Loa Loa (eye worm) | hypothetical protein | 0.0027 | 0.0265 | 0.0269 |
Loa Loa (eye worm) | glutaminase | 0.028 | 0.5695 | 0.579 |
Loa Loa (eye worm) | hypothetical protein | 0.0056 | 0.0877 | 0.0891 |
Onchocerca volvulus | 0.0031 | 0.0339 | 0.0137 | |
Echinococcus granulosus | lamin | 0.0028 | 0.0275 | 0.0173 |
Schistosoma mansoni | tyrosyl-DNA phosphodiesterase | 0.0068 | 0.1134 | 0.1039 |
Mycobacterium tuberculosis | Probable lipase LipE | 0.0037 | 0.0474 | 0.0793 |
Onchocerca volvulus | Polycomb protein Sfmbt homolog | 0.0049 | 0.0731 | 0.0988 |
Brugia malayi | beta-lactamase family protein | 0.0037 | 0.0474 | 0.0482 |
Brugia malayi | Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative | 0.0037 | 0.0474 | 0.0482 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0031 | 0.0339 | 0.0235 |
Brugia malayi | intermediate filament protein | 0.0028 | 0.0275 | 0.028 |
Loa Loa (eye worm) | glutaminase 2 | 0.028 | 0.5695 | 0.579 |
Brugia malayi | beta-lactamase family protein | 0.0037 | 0.0474 | 0.0482 |
Echinococcus multilocularis | histone acetyltransferase MYST2 | 0.0056 | 0.0877 | 0.0791 |
Schistosoma mansoni | hypothetical protein | 0.0297 | 0.606 | 0.6017 |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.0037 | 0.0474 | 0.0658 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0037 | 0.0474 | 0.0658 |
Brugia malayi | Pre-SET motif family protein | 0.0213 | 0.426 | 0.4331 |
Brugia malayi | mbt repeat family protein | 0.0049 | 0.0731 | 0.0744 |
Echinococcus granulosus | histone lysine methyltransferase setb | 0.0031 | 0.0339 | 0.0239 |
Mycobacterium leprae | Probable lipase LipE | 0.0037 | 0.0474 | 0.5 |
Brugia malayi | Tyrosyl-DNA phosphodiesterase family protein | 0.0068 | 0.1134 | 0.1153 |
Schistosoma mansoni | scm-relatedprotein containing 4 mbt domains (sfmbt) | 0.0049 | 0.0731 | 0.0631 |
Onchocerca volvulus | 0.0037 | 0.0474 | 0.0431 | |
Echinococcus multilocularis | SAM and MBT domain containing protein | 0.0049 | 0.0731 | 0.0642 |
Schistosoma mansoni | myelin transcription factor 1 myt1 | 0.0056 | 0.0877 | 0.0778 |
Mycobacterium tuberculosis | Probable lipase LipD | 0.0037 | 0.0474 | 0.0793 |
Mycobacterium tuberculosis | Conserved protein | 0.0037 | 0.0474 | 0.0793 |
Mycobacterium tuberculosis | Conserved protein | 0.0037 | 0.0474 | 0.0793 |
Plasmodium vivax | hypothetical protein, conserved | 0.0037 | 0.0474 | 1 |
Mycobacterium tuberculosis | Probable conserved lipoprotein | 0.0037 | 0.0474 | 0.0793 |
Brugia malayi | C2-HC type zinc finger protein C.e-MyT1 | 0.0056 | 0.0877 | 0.0891 |
Echinococcus multilocularis | lamin | 0.0028 | 0.0275 | 0.0173 |
Echinococcus multilocularis | beta LACTamase domain containing family member | 0.0037 | 0.0474 | 0.0378 |
Brugia malayi | Pre-SET motif family protein | 0.0031 | 0.0339 | 0.0344 |
Mycobacterium ulcerans | lipase LipD | 0.0037 | 0.0474 | 0.0658 |
Echinococcus granulosus | SAM and MBT domain containing protein | 0.0049 | 0.0731 | 0.0642 |
Loa Loa (eye worm) | hypothetical protein | 0.0037 | 0.0474 | 0.0482 |
Trichomonas vaginalis | set domain proteins, putative | 0.0242 | 0.4892 | 0.8564 |
Loa Loa (eye worm) | hypothetical protein | 0.002 | 0.0107 | 0.0109 |
Brugia malayi | mbt repeat family protein | 0.0049 | 0.0731 | 0.0744 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0031 | 0.0339 | 0.0235 |
Entamoeba histolytica | tyrosyl-DNA phosphodiesterase, putative | 0.0068 | 0.1134 | 1 |
Echinococcus multilocularis | histone lysine methyltransferase setb histone lysine methyltransferase eggless | 0.0031 | 0.0339 | 0.0239 |
Schistosoma mansoni | lamin | 0.0028 | 0.0275 | 0.017 |
Loa Loa (eye worm) | hypothetical protein | 0.0037 | 0.0474 | 0.0482 |
Mycobacterium tuberculosis | Probable hydrolase | 0.0037 | 0.0474 | 0.0793 |
Echinococcus granulosus | lamin dm0 | 0.0028 | 0.0275 | 0.0173 |
Loa Loa (eye worm) | hypothetical protein | 0.0028 | 0.0275 | 0.028 |
Trichomonas vaginalis | esterase, putative | 0.0037 | 0.0474 | 0.0658 |
Leishmania major | tyrosyl-DNA phosphodiesterase 1 | 0.0068 | 0.1134 | 1 |
Echinococcus granulosus | 5'partial|histone lysine N methyltransferase SETDB2 | 0.0029 | 0.0315 | 0.0214 |
Mycobacterium leprae | conserved hypothetical protein | 0.0037 | 0.0474 | 0.5 |
Echinococcus multilocularis | tyrosyl DNA phosphodiesterase 1 | 0.0068 | 0.1134 | 0.1056 |
Echinococcus multilocularis | histone lysine N methyltransferase SETMAR | 0.0031 | 0.0339 | 0.0239 |
Echinococcus granulosus | polycomb protein SCMH1 | 0.0049 | 0.0731 | 0.0642 |
Mycobacterium ulcerans | esterase/lipase LipP | 0.0037 | 0.0474 | 0.0658 |
Echinococcus granulosus | beta LACTamase domain containing family member | 0.0037 | 0.0474 | 0.0378 |
Loa Loa (eye worm) | hypothetical protein | 0.0037 | 0.0474 | 0.0482 |
Echinococcus granulosus | endonuclease exonuclease phosphatase | 0.0192 | 0.3817 | 0.3813 |
Onchocerca volvulus | 0.0049 | 0.0731 | 0.0988 | |
Mycobacterium ulcerans | fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE | 0.0037 | 0.0474 | 0.0658 |
Echinococcus multilocularis | polycomb protein SCMH1 | 0.0049 | 0.0731 | 0.0642 |
Schistosoma mansoni | hypothetical protein | 0.0173 | 0.3409 | 0.3338 |
Echinococcus multilocularis | mitogen activated protein kinase kinase kinase | 0.0472 | 0.9835 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0037 | 0.0474 | 0.0482 |
Echinococcus multilocularis | suppression of tumorigenicity 18 protein | 0.0056 | 0.0877 | 0.0791 |
Echinococcus granulosus | geminin | 0.0173 | 0.3409 | 0.3395 |
Echinococcus multilocularis | geminin | 0.0173 | 0.3409 | 0.3395 |
Mycobacterium ulcerans | beta-lactamase | 0.0037 | 0.0474 | 0.0658 |
Echinococcus granulosus | histone acetyltransferase MYST2 | 0.0056 | 0.0877 | 0.0791 |
Loa Loa (eye worm) | TKL/MLK/LZK protein kinase | 0.0472 | 0.9835 | 1 |
Loa Loa (eye worm) | intermediate filament protein | 0.0028 | 0.0275 | 0.028 |
Brugia malayi | ImpB/MucB/SamB family protein | 0.002 | 0.0107 | 0.0109 |
Loa Loa (eye worm) | beta-lactamase | 0.0037 | 0.0474 | 0.0482 |
Schistosoma mansoni | intermediate filament proteins | 0.0028 | 0.0275 | 0.017 |
Echinococcus multilocularis | transcription factor Dp 1 | 0.0039 | 0.0523 | 0.0428 |
Loa Loa (eye worm) | hypothetical protein | 0.0037 | 0.0474 | 0.0482 |
Onchocerca volvulus | 0.0037 | 0.0474 | 0.0431 | |
Loa Loa (eye worm) | tyrosyl-DNA phosphodiesterase | 0.0068 | 0.1134 | 0.1153 |
Schistosoma mansoni | sex comb on midleg homolog | 0.0049 | 0.0731 | 0.0631 |
Mycobacterium tuberculosis | Probable esterase/lipase LipP | 0.0037 | 0.0474 | 0.0793 |
Brugia malayi | Intermediate filament tail domain containing protein | 0.0028 | 0.0275 | 0.028 |
Schistosoma mansoni | lamin | 0.0028 | 0.0275 | 0.017 |
Echinococcus multilocularis | endonuclease exonuclease phosphatase | 0.0192 | 0.3817 | 0.3813 |
Trypanosoma brucei | hypothetical protein, conserved | 0.0037 | 0.0474 | 0.3576 |
Loa Loa (eye worm) | ImpB/MucB/SamB family protein | 0.002 | 0.0107 | 0.0109 |
Loa Loa (eye worm) | mbt repeat family protein | 0.0049 | 0.0731 | 0.0744 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0037 | 0.0474 | 0.0371 |
Echinococcus granulosus | tyrosyl DNA phosphodiesterase 1 | 0.0068 | 0.1134 | 0.1056 |
Schistosoma mansoni | glutaminase | 0.028 | 0.5695 | 0.5648 |
Brugia malayi | ImpB/MucB/SamB family protein | 0.002 | 0.0107 | 0.0109 |
Loa Loa (eye worm) | pre-SET domain-containing protein family protein | 0.0213 | 0.426 | 0.4331 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0037 | 0.0474 | 0.3576 |
Loa Loa (eye worm) | hypothetical protein | 0.0472 | 0.9835 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0049 | 0.0731 | 0.0744 |
Loa Loa (eye worm) | MBCTL1 | 0.0056 | 0.0877 | 0.0891 |
Mycobacterium ulcerans | hypothetical protein | 0.0037 | 0.0474 | 0.0658 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0037 | 0.0474 | 0.0658 |
Brugia malayi | beta-lactamase | 0.0037 | 0.0474 | 0.0482 |
Trypanosoma brucei | tyrosyl-DNA Phosphodiesterase (Tdp1), putative | 0.0068 | 0.1134 | 1 |
Mycobacterium tuberculosis | Conserved protein | 0.0037 | 0.0474 | 0.0793 |
Schistosoma mansoni | sex comb on midleg homolog | 0.0049 | 0.0731 | 0.0631 |
Schistosoma mansoni | hypothetical protein | 0.0173 | 0.3409 | 0.3338 |
Leishmania major | hypothetical protein, conserved | 0.0037 | 0.0474 | 0.3576 |
Echinococcus granulosus | suppression of tumorigenicity 18 protein | 0.0056 | 0.0877 | 0.0791 |
Brugia malayi | Protein kinase domain containing protein | 0.0472 | 0.9835 | 1 |
Echinococcus granulosus | mitogen activated protein kinase kinase kinase | 0.0472 | 0.9835 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0037 | 0.0474 | 0.0482 |
Loa Loa (eye worm) | hypothetical protein | 0.0472 | 0.9835 | 1 |
Trichomonas vaginalis | glutaminase, putative | 0.028 | 0.5695 | 1 |
Echinococcus granulosus | intermediate filament protein | 0.0028 | 0.0275 | 0.0173 |
Mycobacterium ulcerans | glutaminase | 0.028 | 0.5695 | 1 |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.0037 | 0.0474 | 0.0658 |
Echinococcus multilocularis | musashi | 0.0028 | 0.0275 | 0.0173 |
Giardia lamblia | DINP protein human, muc B family | 0.002 | 0.0107 | 0.5 |
Mycobacterium tuberculosis | Possible penicillin-binding protein | 0.0235 | 0.4742 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
EC50 (functional) | 0 ug ml-1 | Positive inotropic activity was assessed in spontaneously beating guinea pig atria; NA=Not active | ChEMBL. | 3172122 |
ED20 (functional) | = 3 mg kg-1 | Effective dose for lowering blood pressure in anesthetized cat when administered intravenously | ChEMBL. | 3172122 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.