Detailed information for compound 83456

Basic information

Technical information
  • TDR Targets ID: 83456
  • Name: 4-[1-(3-aminopropyl)indol-4-yl]-N-[3-(1,1,2,2 -tetrafluoroethoxy)phenyl]pyrimidin-2-amine
  • MW: 459.439 | Formula: C23H21F4N5O
  • H donors: 2 H acceptors: 2 LogP: 4.76 Rotable bonds: 9
    Rule of 5 violations (Lipinski): 1
  • SMILES: NCCCn1ccc2c1cccc2c1ccnc(n1)Nc1cccc(c1)OC(C(F)F)(F)F
  • InChi: 1S/C23H21F4N5O/c24-21(25)23(26,27)33-16-5-1-4-15(14-16)30-22-29-11-8-19(31-22)17-6-2-7-20-18(17)9-13-32(20)12-3-10-28/h1-2,4-9,11,13-14,21H,3,10,12,28H2,(H,29,30,31)
  • InChiKey: HNAIZJDQDDXEGC-UHFFFAOYSA-N  


Substructure search Similarity search

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Synonyms

  • 4-[1-(3-aminopropyl)-4-indolyl]-N-[3-(1,1,2,2-tetrafluoroethoxy)phenyl]-2-pyrimidinamine
  • 4-[1-(3-azanylpropyl)indol-4-yl]-N-[3-(1,1,2,2-tetrafluoroethoxy)phenyl]pyrimidin-2-amine
  • [4-[1-(3-aminopropyl)indol-4-yl]pyrimidin-2-yl]-[3-(1,1,2,2-tetrafluoroethoxy)phenyl]amine
  • 3-[4-[2-[[3-(1,1,2,2-tetrafluoroethoxy)phenyl]amino]pyrimidin-4-yl]indol-1-yl]propylamine

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens protein kinase, cAMP-dependent, catalytic, beta No references
Homo sapiens ABL proto-oncogene 1, non-receptor tyrosine kinase Starlite/ChEMBL No references
Homo sapiens breakpoint cluster region Starlite/ChEMBL References
Homo sapiens protein kinase C, alpha Starlite/ChEMBL No references
Homo sapiens epidermal growth factor receptor Starlite/ChEMBL No references
Homo sapiens SRC proto-oncogene, non-receptor tyrosine kinase Starlite/ChEMBL No references
Homo sapiens protein kinase, cAMP-dependent, catalytic, gamma Starlite/ChEMBL No references
Homo sapiens protein kinase, cAMP-dependent, catalytic, alpha No references
Homo sapiens platelet-derived growth factor receptor, alpha polypeptide Starlite/ChEMBL No references
Homo sapiens protein kinase C, delta Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Schistosoma japonicum Protein kinase C alpha type, putative Get druggable targets OG5_129482 All targets in OG5_129482
Brugia malayi cAMP-dependent protein kinase catalytic subunit, putative Get druggable targets OG5_126748 All targets in OG5_126748
Brugia malayi SRC-1 Get druggable targets OG5_127750 All targets in OG5_127750
Schistosoma japonicum ko:K05085 receptor tyrosine-protein kinase erbB-4, putative Get druggable targets OG5_128597 All targets in OG5_128597
Schistosoma japonicum Epidermal growth factor receptor precursor, putative Get druggable targets OG5_128597 All targets in OG5_128597
Schistosoma japonicum Protein kinase C gamma type, putative Get druggable targets OG5_129482 All targets in OG5_129482
Echinococcus granulosus cAMP dependent protein kinase catalytic subunit Get druggable targets OG5_126748 All targets in OG5_126748
Echinococcus granulosus protein kinase C gamma type Get druggable targets OG5_129482 All targets in OG5_129482
Echinococcus multilocularis tyrosine protein kinase Fyn Get druggable targets OG5_127750 All targets in OG5_127750
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_132502 All targets in OG5_132502
Schistosoma japonicum expressed protein Get druggable targets OG5_131234 All targets in OG5_131234
Toxoplasma gondii protein kinase, cAMP-dependent, catalytic chain Get druggable targets OG5_126748 All targets in OG5_126748
Schistosoma mansoni tyrosine kinase Get druggable targets OG5_128597 All targets in OG5_128597
Onchocerca volvulus Get druggable targets OG5_132502 All targets in OG5_132502
Echinococcus granulosus enhancer of mRNA decapping protein 4 Get druggable targets OG5_126748 All targets in OG5_126748
Cryptosporidium parvum protein kinase, cAMP-dependent, catalytic chain Get druggable targets OG5_126748 All targets in OG5_126748
Trypanosoma cruzi cAMP-dependent protein kinase catalytic subunit 2 Get druggable targets OG5_126748 All targets in OG5_126748
Schistosoma japonicum cAMP-dependent protein kinase catalytic subunit alpha, putative Get druggable targets OG5_126748 All targets in OG5_126748
Trypanosoma brucei gambiense protein kinase A catalytic subunit isoform 1,protein kinase A catalytic subunit Get druggable targets OG5_126748 All targets in OG5_126748
Babesia bovis protein kinase domain containing protein Get druggable targets OG5_126748 All targets in OG5_126748
Leishmania mexicana protein kinase A catalytic subunit isoform 2 Get druggable targets OG5_126748 All targets in OG5_126748
Schistosoma japonicum ko:K04345 protein kinase A, putative Get druggable targets OG5_126748 All targets in OG5_126748
Leishmania donovani protein kinase A catalytic subunit 3 Get druggable targets OG5_126748 All targets in OG5_126748
Brugia malayi protein-tyrosine kinase Get druggable targets OG5_127750 All targets in OG5_127750
Echinococcus granulosus tyrosine protein kinase HCK Get druggable targets OG5_127750 All targets in OG5_127750
Echinococcus multilocularis cAMP dependent protein kinase catalytic subunit Get druggable targets OG5_126748 All targets in OG5_126748
Plasmodium yoelii Protein kinase domain, putative Get druggable targets OG5_126748 All targets in OG5_126748
Leishmania major protein kinase A catalytic subunit isoform 2 Get druggable targets OG5_126748 All targets in OG5_126748
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_129482 All targets in OG5_129482
Trypanosoma brucei cAMP-dependent protein kinase catalytic subunit 2 Get druggable targets OG5_126748 All targets in OG5_126748
Echinococcus granulosus tyrosine protein kinase ABL1 Get druggable targets OG5_131234 All targets in OG5_131234
Schistosoma mansoni serine/threonine protein kinase Get druggable targets OG5_129482 All targets in OG5_129482
Toxoplasma gondii AGC kinase Get druggable targets OG5_126748 All targets in OG5_126748
Echinococcus granulosus tyrosine protein kinase Src42A Get druggable targets OG5_127750 All targets in OG5_127750
Echinococcus multilocularis tyrosine protein kinase Fyn Get druggable targets OG5_127750 All targets in OG5_127750
Loa Loa (eye worm) AGC/PKA protein kinase Get druggable targets OG5_126748 All targets in OG5_126748
Schistosoma japonicum Proto-oncogene tyrosine-protein kinase FGR, putative Get druggable targets OG5_127750 All targets in OG5_127750
Echinococcus multilocularis cAMP dependent protein kinase catalytic subunit Get druggable targets OG5_126748 All targets in OG5_126748
Schistosoma mansoni serine/threonine protein kinase Get druggable targets OG5_126748 All targets in OG5_126748
Schistosoma japonicum Epidermal growth factor receptor precursor, putative Get druggable targets OG5_128597 All targets in OG5_128597
Schistosoma japonicum Tyrosine-protein kinase transforming protein erbB, putative Get druggable targets OG5_128597 All targets in OG5_128597
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_132502 All targets in OG5_132502
Echinococcus granulosus tyrosine kinase|tyrosine protein kinase Fyn Get druggable targets OG5_127750 All targets in OG5_127750
Schistosoma japonicum Proto-oncogene tyrosine-protein kinase FYN, putative Get druggable targets OG5_127750 All targets in OG5_127750
Leishmania braziliensis protein kinase A catalytic subunit Get druggable targets OG5_126748 All targets in OG5_126748
Loa Loa (eye worm) TK/ABL protein kinase Get druggable targets OG5_131234 All targets in OG5_131234
Schistosoma japonicum IPR006212,Furin-like repeat;IPR009030,Growth factor, receptor,domain-containing Get druggable targets OG5_128597 All targets in OG5_128597
Echinococcus multilocularis tyrosine protein kinase Srms Get druggable targets OG5_127750 All targets in OG5_127750
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_131234 All targets in OG5_131234
Echinococcus multilocularis serine threonine protein kinase Get druggable targets OG5_129482 All targets in OG5_129482
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_129482 All targets in OG5_129482
Entamoeba histolytica PH domain containing protein kinase, putative Get druggable targets OG5_126748 All targets in OG5_126748
Schistosoma mansoni serine/threonine protein kinase Get druggable targets OG5_126748 All targets in OG5_126748
Echinococcus granulosus epidermal growth factor receptor Get druggable targets OG5_128597 All targets in OG5_128597
Echinococcus multilocularis tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase Get druggable targets OG5_127750 All targets in OG5_127750
Echinococcus granulosus tyrosine protein kinase Fyn Get druggable targets OG5_127750 All targets in OG5_127750
Loa Loa (eye worm) TK protein kinase Get druggable targets OG5_127750 All targets in OG5_127750
Echinococcus granulosus tyrosine protein kinase Fyn Get druggable targets OG5_127750 All targets in OG5_127750
Echinococcus granulosus proto oncogene tyrosine protein kinase LCK Get druggable targets OG5_127750 All targets in OG5_127750
Echinococcus multilocularis tyrosine protein kinase Src42A Get druggable targets OG5_127750 All targets in OG5_127750
Schistosoma japonicum Tyrosine-protein kinase transforming protein Abl, putative Get druggable targets OG5_131234 All targets in OG5_131234
Leishmania infantum protein kinase A catalytic subunit Get druggable targets OG5_126748 All targets in OG5_126748
Loa Loa (eye worm) AGC/PKA protein kinase Get druggable targets OG5_126748 All targets in OG5_126748
Echinococcus granulosus cAMP dependent protein kinase catalytic subunit Get druggable targets OG5_126748 All targets in OG5_126748
Schistosoma japonicum hypothetical protein Get druggable targets OG5_128597 All targets in OG5_128597
Schistosoma japonicum Protein kinase C alpha type, putative Get druggable targets OG5_129482 All targets in OG5_129482
Cryptosporidium hominis protein kinase (EC 2.7.1.37), cAMP-dependent, catalytic chain Get druggable targets OG5_126748 All targets in OG5_126748
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126748 All targets in OG5_126748
Echinococcus granulosus melanoma receptor tyrosine protein kinase Get druggable targets OG5_128597 All targets in OG5_128597
Echinococcus multilocularis tyrosine protein kinase Fgr Get druggable targets OG5_127750 All targets in OG5_127750
Entamoeba histolytica PH domain containing protein kinase, putative Get druggable targets OG5_126748 All targets in OG5_126748
Plasmodium berghei cAMP-dependent protein kinase catalytic subunit Get druggable targets OG5_126748 All targets in OG5_126748
Echinococcus granulosus tyrosine protein kinase Src64B Get druggable targets OG5_127750 All targets in OG5_127750
Echinococcus multilocularis tyrosine protein kinase Fyn Get druggable targets OG5_127750 All targets in OG5_127750
Schistosoma japonicum Protein kinase DC2, putative Get druggable targets OG5_126748 All targets in OG5_126748
Echinococcus multilocularis epidermal growth factor receptor Get druggable targets OG5_128597 All targets in OG5_128597
Echinococcus multilocularis tyrosine protein kinase Abl Get druggable targets OG5_131234 All targets in OG5_131234
Trypanosoma congolense cAMP-dependent protein kinase catalytic subunit 1 Get druggable targets OG5_126748 All targets in OG5_126748
Schistosoma japonicum expressed protein Get druggable targets OG5_128597 All targets in OG5_128597
Schistosoma japonicum IPR000719,Protein kinase;IPR011009,Protein kinase-like,domain-containing Get druggable targets OG5_126748 All targets in OG5_126748
Echinococcus granulosus tyrosine kinase Get druggable targets OG5_127750 All targets in OG5_127750
Echinococcus multilocularis tyrosine protein kinase Src64B Get druggable targets OG5_127750 All targets in OG5_127750
Schistosoma japonicum Receptor tyrosine-protein kinase erbB-2 precursor, putative Get druggable targets OG5_128597 All targets in OG5_128597
Schistosoma mansoni tyrosine kinase Get druggable targets OG5_127750 All targets in OG5_127750
Trypanosoma brucei cAMP-dependent protein kinase catalytic subunit 1 Get druggable targets OG5_126748 All targets in OG5_126748
Theileria parva cAMP-dependent protein kinase catalytic subunit, putative Get druggable targets OG5_126748 All targets in OG5_126748
Loa Loa (eye worm) TK/EGFR protein kinase Get druggable targets OG5_128597 All targets in OG5_128597
Candida albicans cAMP-dependent protein kinase Get druggable targets OG5_126748 All targets in OG5_126748
Schistosoma japonicum Epidermal growth factor receptor precursor, putative Get druggable targets OG5_128597 All targets in OG5_128597
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_132502 All targets in OG5_132502
Brugia malayi Protein kinase c protein 2 Get druggable targets OG5_129482 All targets in OG5_129482
Schistosoma mansoni tyrosine kinase Get druggable targets OG5_128597 All targets in OG5_128597
Echinococcus multilocularis RNA directed DNA polymerase Get druggable targets OG5_129482 All targets in OG5_129482
Schistosoma mansoni tyrosine kinase Get druggable targets OG5_127750 All targets in OG5_127750
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_132502 All targets in OG5_132502
Trypanosoma brucei protein kinase A catalytic subunit, putative Get druggable targets OG5_126748 All targets in OG5_126748
Trypanosoma cruzi cAMP-dependent protein kinase catalytic subunit 3 Get druggable targets OG5_126748 All targets in OG5_126748
Candida albicans cAMP-dependent protein kinase Get druggable targets OG5_126748 All targets in OG5_126748
Schistosoma japonicum ko:K08892 fyn-related kinase, putative Get druggable targets OG5_127750 All targets in OG5_127750
Echinococcus granulosus RNA directed DNA polymerase Get druggable targets OG5_129482 All targets in OG5_129482
Echinococcus granulosus active breakpoint cluster region Get druggable targets OG5_131841 All targets in OG5_131841
Schistosoma japonicum ko:K05703 proto-oncogene tyrosine-protein kinase Fyn, putative Get druggable targets OG5_127750 All targets in OG5_127750
Echinococcus multilocularis tyrosine protein kinase Blk Get druggable targets OG5_127750 All targets in OG5_127750
Schistosoma mansoni tyrosine kinase Get druggable targets OG5_131234 All targets in OG5_131234
Echinococcus multilocularis tyrosine protein kinase Fyn Get druggable targets OG5_127750 All targets in OG5_127750
Schistosoma japonicum Epidermal growth factor receptor precursor, putative Get druggable targets OG5_128597 All targets in OG5_128597
Trypanosoma congolense protein kinase A catalytic subunit 3 Get druggable targets OG5_126748 All targets in OG5_126748
Brugia malayi Tyrosine-protein kinase abl-1 Get druggable targets OG5_131234 All targets in OG5_131234
Schistosoma mansoni serine/threonine protein kinase Get druggable targets OG5_126748 All targets in OG5_126748
Echinococcus granulosus tyrosine protein kinase Fyn Get druggable targets OG5_127750 All targets in OG5_127750
Loa Loa (eye worm) SRC-1 Get druggable targets OG5_127750 All targets in OG5_127750
Echinococcus multilocularis active breakpoint cluster region Get druggable targets OG5_131841 All targets in OG5_131841
Leishmania infantum protein kinase A catalytic subunit isoform 2 Get druggable targets OG5_126748 All targets in OG5_126748
Neospora caninum AGC kinase, putative Get druggable targets OG5_126748 All targets in OG5_126748
Brugia malayi Furin-like cysteine rich region family protein Get druggable targets OG5_128597 All targets in OG5_128597
Echinococcus multilocularis cAMP dependent protein kinase catalytic subunit Get druggable targets OG5_126748 All targets in OG5_126748
Plasmodium falciparum cAMP-dependent protein kinase catalytic subunit Get druggable targets OG5_126748 All targets in OG5_126748
Entamoeba histolytica protein kinase, putative Get druggable targets OG5_127750 All targets in OG5_127750
Schistosoma japonicum IPR000477,RNA-directed DNA polymerase (Reverse transcriptase),domain-containing Get druggable targets OG5_129482 All targets in OG5_129482
Schistosoma japonicum Receptor tyrosine-protein kinase erbB-4 precursor, putative Get druggable targets OG5_128597 All targets in OG5_128597
Schistosoma japonicum Proto-oncogene tyrosine-protein kinase FYN, putative Get druggable targets OG5_127750 All targets in OG5_127750
Echinococcus multilocularis tyrosine protein kinase Src42A Get druggable targets OG5_127750 All targets in OG5_127750
Echinococcus granulosus Protein kinase C brain isozyme Get druggable targets OG5_129482 All targets in OG5_129482
Echinococcus multilocularis cAMP dependent protein kinase catalytic subunit Get druggable targets OG5_126748 All targets in OG5_126748
Giardia lamblia Kinase, AGC PKA Get druggable targets OG5_126748 All targets in OG5_126748
Leishmania major protein kinase A catalytic subunit isoform 1 Get druggable targets OG5_126748 All targets in OG5_126748
Toxoplasma gondii AGC kinase Get druggable targets OG5_126748 All targets in OG5_126748
Echinococcus multilocularis Protein kinase C, brain isozyme Get druggable targets OG5_129482 All targets in OG5_129482
Trypanosoma congolense cAMP-dependent protein kinase catalytic subunit 1 Get druggable targets OG5_126748 All targets in OG5_126748
Plasmodium vivax cAMP-dependent protein kinase catalytic subunit, putative Get druggable targets OG5_126748 All targets in OG5_126748
Echinococcus multilocularis enhancer of mRNA decapping protein 4 Get druggable targets OG5_126748 All targets in OG5_126748
Trypanosoma cruzi cAMP-dependent protein kinase catalytic subunit 1 Get druggable targets OG5_126748 All targets in OG5_126748
Schistosoma japonicum Proto-oncogene tyrosine-protein kinase ABL1, putative Get druggable targets OG5_131234 All targets in OG5_131234
Candida albicans protein kinase C similar to S. cerevisiae PKC1 (YBL105C) Get druggable targets OG5_129482 All targets in OG5_129482
Plasmodium knowlesi cAMP-dependent protein kinase catalytic subunit, putative Get druggable targets OG5_126748 All targets in OG5_126748
Schistosoma japonicum cAMP-dependent protein kinase catalytic subunit alpha, putative Get druggable targets OG5_126748 All targets in OG5_126748
Leishmania braziliensis protein kinase A catalytic subunit isoform 1 Get druggable targets OG5_126748 All targets in OG5_126748
Schistosoma japonicum IPR000494,EGF receptor, L domain,domain-containing Get druggable targets OG5_128597 All targets in OG5_128597
Leishmania infantum protein kinase A catalytic subunit isoform 1 Get druggable targets OG5_126748 All targets in OG5_126748
Schistosoma japonicum expressed protein Get druggable targets OG5_131234 All targets in OG5_131234
Echinococcus multilocularis epidermal growth factor receptor Get druggable targets OG5_128597 All targets in OG5_128597
Trypanosoma brucei gambiense protein kinase A catalytic subunit isoform 2,protein kinase A catalytic subunit Get druggable targets OG5_126748 All targets in OG5_126748
Schistosoma mansoni tyrosine kinase Get druggable targets OG5_128597 All targets in OG5_128597
Trypanosoma cruzi cAMP-dependent protein kinase catalytic subunit 3 Get druggable targets OG5_126748 All targets in OG5_126748
Theileria parva cAMP-dependent protein kinase, putative Get druggable targets OG5_126748 All targets in OG5_126748
Schistosoma japonicum cAMP-dependent protein kinase catalytic subunit, putative Get druggable targets OG5_126748 All targets in OG5_126748
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_132502 All targets in OG5_132502
Candida albicans protein kinase A Get druggable targets OG5_126748 All targets in OG5_126748
Trichomonas vaginalis AGC family protein kinase Get druggable targets OG5_126748 All targets in OG5_126748
Echinococcus granulosus epidermal growth factor receptor Get druggable targets OG5_128597 All targets in OG5_128597
Leishmania major protein kinase A catalytic subunit Get druggable targets OG5_126748 All targets in OG5_126748
Echinococcus granulosus tyrosine protein kinase Src42A Get druggable targets OG5_127750 All targets in OG5_127750
Echinococcus granulosus tyrosine protein kinase Blk Get druggable targets OG5_127750 All targets in OG5_127750
Schistosoma mansoni tyrosine kinase Get druggable targets OG5_128597 All targets in OG5_128597
Schistosoma japonicum Tyrosine-protein kinase transforming protein Abl, putative Get druggable targets OG5_131234 All targets in OG5_131234
Candida albicans protein kinase C similar to S. cerevisiae PKC1 (YBL105C) Get druggable targets OG5_129482 All targets in OG5_129482
Echinococcus multilocularis proto oncogene tyrosine protein kinase LCK Get druggable targets OG5_127750 All targets in OG5_127750
Trypanosoma brucei gambiense protein kinase A catalytic subunit Get druggable targets OG5_126748 All targets in OG5_126748
Loa Loa (eye worm) AGC/PKC/ALPHA protein kinase Get druggable targets OG5_129482 All targets in OG5_129482
Echinococcus multilocularis tyrosine protein kinase ABL1 Get druggable targets OG5_131234 All targets in OG5_131234
Leishmania mexicana protein kinase A catalytic subunit isoform 1 Get druggable targets OG5_126748 All targets in OG5_126748
Leishmania mexicana protein kinase A catalytic subunit Get druggable targets OG5_126748 All targets in OG5_126748
Neospora caninum AGC kinase, putative Get druggable targets OG5_126748 All targets in OG5_126748
Echinococcus multilocularis telomerase reverse transcriptase subunit Get druggable targets OG5_129482 All targets in OG5_129482
Echinococcus granulosus cAMP dependent protein kinase catalytic subunit Get druggable targets OG5_126748 All targets in OG5_126748
Schistosoma japonicum Epidermal growth factor receptor precursor, putative Get druggable targets OG5_128597 All targets in OG5_128597
Schistosoma japonicum Calcium-dependent protein kinase C, putative Get druggable targets OG5_129482 All targets in OG5_129482
Loa Loa (eye worm) TK protein kinase Get druggable targets OG5_127750 All targets in OG5_127750
Candida albicans protein kinase A Get druggable targets OG5_126748 All targets in OG5_126748
Echinococcus multilocularis tyrosine protein kinase HCK Get druggable targets OG5_127750 All targets in OG5_127750
Schistosoma japonicum Proto-oncogene tyrosine-protein kinase Yrk, putative Get druggable targets OG5_127750 All targets in OG5_127750
Schistosoma mansoni tyrosine kinase Get druggable targets OG5_128597 All targets in OG5_128597
Echinococcus multilocularis tyrosine protein kinase lyn tyrosine protein kinase blk Get druggable targets OG5_127750 All targets in OG5_127750
Schistosoma japonicum ko:K04345 protein kinase A, putative Get druggable targets OG5_126748 All targets in OG5_126748
Echinococcus multilocularis Get druggable targets OG5_128597 All targets in OG5_128597
Echinococcus granulosus 3'partial|tyrosine protein kinase Fgr Get druggable targets OG5_127750 All targets in OG5_127750
Schistosoma mansoni serine/threonine protein kinase Get druggable targets OG5_129482 All targets in OG5_129482
Echinococcus granulosus tyrosine protein kinase Lyn Get druggable targets OG5_127750 All targets in OG5_127750
Schistosoma mansoni tyrosine kinase Get druggable targets OG5_128597 All targets in OG5_128597
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Trypanosoma brucei protein lipid droplet kinase (LDK) protein kinase, cAMP-dependent, catalytic, beta 358 aa 320 aa 27.8 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus tyrosine protein kinase Fps85D 0.0013 0.0084 0.0084
Trichomonas vaginalis AGC family protein kinase 0.0025 0.0549 0.0176
Brugia malayi RhoGAP domain containing protein 0.0025 0.0541 0.0779
Trichomonas vaginalis AGC family protein kinase 0.0025 0.0549 0.0176
Schistosoma mansoni serine/threonine protein kinase 0.0025 0.0549 0.0494
Loa Loa (eye worm) hypothetical protein 0.0016 0.0212 0.0207
Echinococcus granulosus tyrosine protein kinase Srms 0.0013 0.0084 0.0084
Schistosoma mansoni proto-oncogene tyrosine-protein kinase abl1 0.0016 0.0202 0.0131
Brugia malayi Protein kinase domain containing protein 0.0025 0.0549 0.0792
Echinococcus granulosus tyrosine protein kinase Fyn 0.0056 0.1803 0.1803
Loa Loa (eye worm) TK/ABL protein kinase 0.0262 1 1
Schistosoma mansoni tyrosine kinase 0.0062 0.2008 0.2014
Schistosoma mansoni diacylglycerol kinase theta 0.0016 0.0212 0.0142
Echinococcus multilocularis tyrosine protein kinase ABL1 0.0262 1 1
Loa Loa (eye worm) TK/FER protein kinase 0.0013 0.0084 0.0079
Onchocerca volvulus 0.0016 0.0212 0.021
Echinococcus multilocularis ribosomal protein s6 kinase beta 1 0.0025 0.0549 0.0549
Loa Loa (eye worm) AGC/RSK/P70 protein kinase 0.0025 0.0549 0.0545
Loa Loa (eye worm) AGC/PKA protein kinase 0.0146 0.5387 0.5384
Schistosoma mansoni protein kinase C mu 0.0019 0.0298 0.0232
Schistosoma mansoni tyrosine kinase 0.0101 0.357 0.364
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0056 0.1803 0.1803
Loa Loa (eye worm) hypothetical protein 0.0016 0.0212 0.0207
Loa Loa (eye worm) hypothetical protein 0.0019 0.0333 0.0328
Trichomonas vaginalis AGC family protein kinase 0.0025 0.0549 0.0176
Trichomonas vaginalis AGC family protein kinase 0.0025 0.0549 0.0176
Brugia malayi cAMP-dependent protein kinase catalytic subunit, putative 0.0146 0.5387 0.782
Echinococcus multilocularis tyrosine protein kinase HCK 0.004 0.116 0.116
Echinococcus granulosus myotubularin protein 13 0.0016 0.0212 0.0212
Schistosoma mansoni serine/threonine protein kinase 0.0146 0.5387 0.5533
Echinococcus granulosus raf serine:threonine protein kinase 0.0021 0.0412 0.0412
Echinococcus multilocularis tyrosine protein kinase Abl 0.0116 0.4193 0.4193
Loa Loa (eye worm) AGC/PKA protein kinase 0.0146 0.5387 0.5384
Schistosoma mansoni unc-13 (munc13) 0.0019 0.0333 0.0268
Echinococcus granulosus tyrosine protein kinase Fyn 0.0056 0.1803 0.1803
Loa Loa (eye worm) AGC/PKC/ALPHA protein kinase 0.0053 0.1661 0.1657
Echinococcus granulosus insulin growth factor 1 receptor beta 0.0062 0.2008 0.2008
Echinococcus multilocularis serine:threonine protein kinase MRCK beta 0.0019 0.0298 0.0298
Echinococcus multilocularis Protein kinase C, brain isozyme 0.0092 0.322 0.322
Loa Loa (eye worm) TK/FER protein kinase 0.0013 0.0084 0.0079
Schistosoma mansoni tyrosine kinase 0.0056 0.1803 0.18
Echinococcus multilocularis insulin growth factor 1 receptor beta 0.0062 0.2008 0.2008
Trypanosoma brucei cAMP-dependent protein kinase catalytic subunit 1 0.0146 0.5387 1
Echinococcus multilocularis NCK adaptor protein 0.0016 0.0202 0.0202
Schistosoma mansoni tyrosine kinase 0.0062 0.2008 0.2014
Schistosoma mansoni tyrosine kinase 0.0056 0.1803 0.18
Loa Loa (eye worm) hypothetical protein 0.0016 0.0215 0.021
Schistosoma mansoni nck2/grb4 0.0016 0.0202 0.0131
Echinococcus granulosus protein kinase c iota type 0.0041 0.1203 0.1203
Brugia malayi SH2 domain containing protein 0.0013 0.0084 0.0115
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0043 0.1286 0.1286
Echinococcus multilocularis serine:threonine protein kinase 38 0.0025 0.0549 0.0549
Trypanosoma cruzi cAMP-dependent protein kinase catalytic subunit 3 0.0146 0.5387 0.5
Brugia malayi Protein kinase domain containing protein 0.0013 0.0084 0.0115
Brugia malayi Protein kinase domain containing protein 0.0013 0.0084 0.0115
Schistosoma mansoni growth factor receptor-bound protein 0.0016 0.0202 0.0131
Echinococcus multilocularis serine threonine protein kinase 0.0076 0.2566 0.2566
Loa Loa (eye worm) hypothetical protein 0.0016 0.0212 0.0207
Schistosoma mansoni serine/threonine protein kinase 0.0146 0.5387 0.5533
Brugia malayi protein-tyrosine kinase 0.0048 0.1486 0.2152
Echinococcus granulosus growth factor receptor bound protein 2 0.0016 0.0202 0.0202
Schistosoma mansoni serine/threonine protein kinase 0.0019 0.0298 0.0232
Loa Loa (eye worm) AGC/NDR protein kinase 0.0025 0.0549 0.0545
Entamoeba histolytica protein kinase, putative 0.004 0.116 0.2029
Brugia malayi Protein kinase domain containing protein 0.0013 0.0084 0.0115
Toxoplasma gondii AGC kinase 0.0025 0.0549 0.0652
Schistosoma mansoni rac gtpase activating protein 0.0016 0.0215 0.0145
Onchocerca volvulus 0.0167 0.6193 1
Leishmania major protein kinase A catalytic subunit 0.0146 0.5387 0.5
Brugia malayi Tyrosine-protein kinase abl-1 0.0116 0.4193 0.6085
Echinococcus granulosus tyrosine protein kinase Blk 0.0048 0.1486 0.1486
Schistosoma mansoni serine/threonine protein kinase 0.0092 0.322 0.3276
Echinococcus multilocularis guanine nucleotide exchange factor VAV2 0.0025 0.0541 0.0541
Schistosoma mansoni serine/threonine kinase 0.0025 0.0549 0.0494
Echinococcus multilocularis tyrosine protein kinase lyn tyrosine protein kinase blk 0.0056 0.1803 0.1803
Onchocerca volvulus 0.0016 0.0212 0.021
Schistosoma mansoni diacylglycerol kinase theta 0.0016 0.0212 0.0142
Loa Loa (eye worm) TK/FER protein kinase 0.0013 0.0084 0.0079
Echinococcus multilocularis epidermal growth factor receptor 0.0101 0.357 0.357
Schistosoma mansoni growth factor receptor-bound protein 0.0016 0.0202 0.0131
Schistosoma mansoni tyrosine kinase 0.0021 0.0401 0.0339
Schistosoma mansoni serine/threonine protein kinase 0.0025 0.0549 0.0494
Echinococcus granulosus NCK adaptor protein 0.0016 0.0202 0.0202
Echinococcus multilocularis N chimaerin 0.0025 0.0541 0.0541
Loa Loa (eye worm) hypothetical protein 0.0183 0.6847 0.6846
Brugia malayi diacylglycerol kinase 0.0016 0.0212 0.0301
Entamoeba histolytica protein kinase, putative 0.0025 0.0549 0.0878
Loa Loa (eye worm) TK/EGFR protein kinase 0.0184 0.6887 0.6886
Echinococcus multilocularis proto oncogene tyrosine protein kinase LCK 0.0056 0.1803 0.1803
Schistosoma mansoni tyrosine kinase 0.0013 0.0084 0.0008
Echinococcus granulosus N chimaerin 0.0025 0.0541 0.0541
Trichomonas vaginalis AGC family protein kinase 0.0025 0.0549 0.0176
Echinococcus granulosus epidermal growth factor receptor 0.0101 0.357 0.357
Loa Loa (eye worm) RhoGAP domain-containing protein 0.0025 0.0541 0.0536
Echinococcus granulosus epidermal growth factor receptor 0.0184 0.6887 0.6887
Brugia malayi RhoGAP domain containing protein 0.0016 0.0215 0.0306
Echinococcus granulosus ribosomal protein s6 kinase beta 1 0.0025 0.0549 0.0549
Schistosoma mansoni serine/threonine protein kinase 0.0044 0.1324 0.1301
Brugia malayi diacylglycerol kinase 0.0016 0.0212 0.0301
Toxoplasma gondii protein kinase, cAMP-dependent, catalytic chain 0.0146 0.5387 1
Loa Loa (eye worm) sex muscle abnormal protein 5 0.0016 0.0202 0.0197
Trichomonas vaginalis AGC family protein kinase 0.0025 0.0549 0.0176
Schistosoma mansoni tyrosine kinase 0.0096 0.337 0.3432
Schistosoma mansoni tyrosine kinase 0.0101 0.357 0.364
Echinococcus multilocularis tyrosine protein kinase Blk 0.0048 0.1486 0.1486
Loa Loa (eye worm) TK/INSR protein kinase 0.0062 0.2008 0.2005
Loa Loa (eye worm) TK/FER protein kinase 0.0013 0.0084 0.0079
Schistosoma mansoni tyrosine kinase 0.0184 0.6887 0.7096
Trichomonas vaginalis AGC family protein kinase 0.0025 0.0549 0.0176
Giardia lamblia Kinase, AGC PKA 0.0146 0.5387 0.5
Echinococcus multilocularis tyrosine protein kinase Fgr 0.0056 0.1803 0.1803
Brugia malayi RhoGEF domain containing protein 0.0017 0.0215 0.0306
Loa Loa (eye worm) hypothetical protein 0.0016 0.0212 0.0207
Echinococcus multilocularis insulin receptor 0.0062 0.2008 0.2008
Echinococcus granulosus tyrosine protein kinase Lyn 0.0059 0.189 0.189
Echinococcus multilocularis serine:threonine protein kinase N2 0.0025 0.0549 0.0549
Echinococcus multilocularis enhancer of mRNA decapping protein 4 0.0144 0.53 0.53
Schistosoma mansoni serine/threonine protein kinase 0.0092 0.322 0.3276
Echinococcus granulosus Rac GTPase activating protein 1 0.0016 0.0215 0.0215
Echinococcus multilocularis Diacylglycerol kinase theta 0.0016 0.0212 0.0212
Trichomonas vaginalis AGC family protein kinase 0.0025 0.0549 0.0176
Brugia malayi Sex muscle abnormal protein 5 0.0016 0.0202 0.0286
Schistosoma mansoni tyrosine kinase 0.0021 0.0401 0.0339
Echinococcus granulosus cAMP dependent protein kinase catalytic subunit 0.0146 0.5387 0.5387
Brugia malayi C1-like domain containing protein 0.0019 0.0298 0.0427
Echinococcus granulosus tyrosine protein kinase shark 0.0013 0.0084 0.0084
Trichomonas vaginalis AGC family protein kinase 0.0025 0.0549 0.0176
Echinococcus granulosus tyrosine kinase|tyrosine protein kinase Fyn 0.0048 0.1486 0.1486
Brugia malayi Protein kinase domain containing protein 0.0062 0.2008 0.2911
Brugia malayi Protein kinase domain containing protein 0.0019 0.0298 0.0427
Schistosoma mansoni tyrosine kinase 0.0013 0.0084 0.0008
Loa Loa (eye worm) AGC/PKN protein kinase 0.0025 0.0549 0.0545
Echinococcus multilocularis RNA directed DNA polymerase 0.0048 0.1454 0.1454
Echinococcus granulosus protein kinase C gamma type 0.0076 0.2566 0.2566
Echinococcus multilocularis Rac GTPase activating protein 1 0.0016 0.0215 0.0215
Brugia malayi Variant SH3 domain containing protein 0.0016 0.0202 0.0286
Brugia malayi Pleckstrin Homology Domain 0.0016 0.0212 0.0301
Echinococcus granulosus tyrosine protein kinase Src42A 0.0056 0.1803 0.1803
Loa Loa (eye worm) hypothetical protein 0.0167 0.6193 0.6192
Schistosoma mansoni serine/threonine protein kinase 0.0025 0.0549 0.0494
Echinococcus granulosus tyrosine kinase 0.0013 0.0084 0.0084
Plasmodium falciparum cAMP-dependent protein kinase catalytic subunit 0.0146 0.5387 0.5
Brugia malayi protein kinase C3,putative 0.0019 0.0298 0.0427
Echinococcus multilocularis 0.0056 0.1777 0.1777
Echinococcus granulosus enhancer of mRNA decapping protein 4 0.0144 0.53 0.53
Schistosoma mansoni adapter molecule crk 0.0016 0.0202 0.0131
Brugia malayi Variant SH3 domain containing protein 0.0025 0.0541 0.078
Echinococcus multilocularis serine:threonine protein kinase N2 0.0025 0.0549 0.0549
Brugia malayi SRC-1 0.0056 0.1803 0.2613
Schistosoma mansoni hypothetical protein 0.0016 0.0212 0.0142
Loa Loa (eye worm) raf kinase 0.0016 0.0212 0.0207
Loa Loa (eye worm) hypothetical protein 0.01 0.355 0.3547
Trichomonas vaginalis AGC family protein kinase 0.0146 0.5387 1
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0056 0.1803 0.1803
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0048 0.1486 0.1486
Schistosoma mansoni serine/threonine protein kinase 0.0019 0.0298 0.0232
Loa Loa (eye worm) TK/FER protein kinase 0.0013 0.0084 0.0079
Trypanosoma cruzi cAMP-dependent protein kinase catalytic subunit 2 0.0146 0.5387 0.5
Echinococcus multilocularis cAMP dependent protein kinase catalytic subunit 0.0146 0.5387 0.5387
Loa Loa (eye worm) TK/FER protein kinase 0.0013 0.0084 0.0079
Echinococcus multilocularis epidermal growth factor receptor 0.0184 0.6887 0.6887
Schistosoma mansoni tyrosine kinase 0.0096 0.337 0.3432
Echinococcus granulosus tyrosine protein kinase HCK 0.004 0.116 0.116
Toxoplasma gondii AGC kinase 0.0146 0.5387 1
Echinococcus multilocularis ribosomal protein S6 kinase alpha 3 0.0025 0.0549 0.0549
Echinococcus multilocularis C2 calcium dependent membrane targeting 0.0019 0.0333 0.0333
Loa Loa (eye worm) hypothetical protein 0.0048 0.1454 0.145
Entamoeba histolytica diacylglycerol kinase, putative 0.0016 0.0212 0.0242
Echinococcus granulosus ribosomal protein S6 kinase alpha 3 0.0025 0.0549 0.0549
Echinococcus multilocularis tyrosine protein kinase Fps85D 0.0013 0.0084 0.0084
Loa Loa (eye worm) AGC/PKC/ETA protein kinase 0.0044 0.1324 0.132
Echinococcus multilocularis raf serine:threonine protein kinase 0.0021 0.0412 0.0412
Trypanosoma cruzi cAMP-dependent protein kinase catalytic subunit 1 0.0146 0.5387 0.5
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0056 0.1803 0.1803
Trypanosoma brucei protein kinase A catalytic subunit, putative 0.0146 0.5387 1
Echinococcus multilocularis tyrosine protein kinase shark 0.0013 0.0084 0.0084
Plasmodium vivax cAMP-dependent protein kinase catalytic subunit, putative 0.0146 0.5387 0.5
Echinococcus granulosus RNA directed DNA polymerase 0.0048 0.1454 0.1454
Echinococcus multilocularis cAMP dependent protein kinase catalytic subunit 0.0146 0.5387 0.5387
Schistosoma mansoni tyrosine kinase 0.0254 0.9674 1
Loa Loa (eye worm) hypothetical protein 0.0016 0.0212 0.0207
Brugia malayi Protein kinase domain containing protein 0.0025 0.0549 0.0792
Brugia malayi Furin-like cysteine rich region family protein 0.0184 0.6887 1
Trichomonas vaginalis AGC family protein kinase 0.0025 0.0549 0.0176
Loa Loa (eye worm) TK/FER protein kinase 0.0013 0.0084 0.0079
Echinococcus granulosus tyrosine protein kinase Btk29A 0.0021 0.0401 0.0401
Brugia malayi Ras association domain family 1 isoform A 0.0016 0.0212 0.0301
Schistosoma mansoni protein kinase C 0.0019 0.0333 0.0268
Echinococcus granulosus cAMP dependent protein kinase catalytic subunit 0.0146 0.5387 0.5387
Brugia malayi Tyrosine-protein kinase abl-1 0.0154 0.5683 0.825
Loa Loa (eye worm) variant SH3 domain-containing protein 0.0017 0.0215 0.0211
Schistosoma mansoni atypical protein kinase C 0.0041 0.1203 0.1175
Schistosoma mansoni chimerin-related rho-gtpase-activating protein 0.0025 0.0541 0.0485
Schistosoma mansoni serine/threonine protein kinase 0.0025 0.0549 0.0494
Echinococcus multilocularis Ribosomal protein S6 kinase beta 2 0.0025 0.0549 0.0549
Brugia malayi SH2 domain containing protein 0.0013 0.0084 0.0115
Trypanosoma cruzi cAMP-dependent protein kinase catalytic subunit 3 0.0146 0.5387 0.5
Echinococcus multilocularis tyrosine protein kinase Srms 0.0048 0.1486 0.1486
Echinococcus granulosus 3'partial|tyrosine protein kinase Fgr 0.0056 0.1803 0.1803
Loa Loa (eye worm) hypothetical protein 0.0016 0.0212 0.0207
Loa Loa (eye worm) AGC/DMPK/GEK protein kinase 0.0025 0.0549 0.0545
Loa Loa (eye worm) SRC-1 0.0056 0.1803 0.1799
Echinococcus granulosus tyrosine protein kinase Src42A 0.0043 0.1286 0.1286
Entamoeba histolytica PH domain containing protein kinase, putative 0.0146 0.5387 1
Brugia malayi hypothetical protein 0.0013 0.0084 0.0115
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0056 0.1803 0.1803
Echinococcus multilocularis tyrosine protein kinase Btk29A 0.0021 0.0401 0.0401
Schistosoma mansoni tyrosine kinase 0.0096 0.337 0.3432
Echinococcus multilocularis c src tyrosine kinase 0.0021 0.0401 0.0401
Entamoeba histolytica protein kinase, putative 0.0025 0.0549 0.0878
Brugia malayi Phorbol esters/diacylglycerol binding domain 0.0019 0.0298 0.0427
Echinococcus multilocularis tyrosine protein kinase Src64B 0.0056 0.1803 0.1803
Echinococcus granulosus Ribosomal protein S6 kinase beta 2 0.0025 0.0549 0.0549
Echinococcus granulosus Diacylglycerol kinase theta 0.0016 0.0212 0.0212
Leishmania major protein kinase A catalytic subunit isoform 2 0.0146 0.5387 0.5
Loa Loa (eye worm) hypothetical protein 0.0016 0.0212 0.0207
Brugia malayi Protein kinase domain containing protein 0.0013 0.0084 0.0115
Loa Loa (eye worm) CAMK/PKD protein kinase 0.0019 0.0298 0.0294
Toxoplasma gondii AGC kinase 0.0146 0.5387 1
Echinococcus multilocularis protein kinase c iota type 0.0041 0.1203 0.1203
Echinococcus granulosus melanoma receptor tyrosine protein kinase 0.0101 0.357 0.357
Brugia malayi p70 ribosomal S6 kinase beta 0.0025 0.0549 0.0792
Echinococcus multilocularis growth factor receptor bound protein 2 0.0016 0.0202 0.0202
Entamoeba histolytica diacylglycerol kinase, putative 0.0016 0.0212 0.0242
Echinococcus granulosus tyrosine protein kinase Src64B 0.0056 0.1803 0.1803
Brugia malayi Protein kinase c protein 2 0.0069 0.2315 0.3357
Leishmania major protein kinase A catalytic subunit isoform 1 0.0146 0.5387 0.5
Schistosoma mansoni chimerin-related rho-gtpase-activating protein 0.0025 0.0541 0.0485
Loa Loa (eye worm) variant SH3 domain-containing protein 0.0016 0.0202 0.0197
Schistosoma mansoni proto-oncogene tyrosine-protein kinase src 0.0021 0.0401 0.0339
Echinococcus granulosus unc 13 munc13 0.0019 0.0333 0.0333
Schistosoma mansoni serine/threonine protein kinase 0.0146 0.5387 0.5533
Echinococcus granulosus c src tyrosine kinase 0.0021 0.0401 0.0401
Echinococcus granulosus active breakpoint cluster region 0.0123 0.4465 0.4465
Echinococcus multilocularis protein kinase c eta type 0.0016 0.0212 0.0212
Echinococcus multilocularis protein kinase c epsilon type 0.0044 0.1324 0.1324
Loa Loa (eye worm) AGC/RSK/RSK protein kinase 0.0025 0.0549 0.0545
Echinococcus multilocularis tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase 0.0056 0.1803 0.1803
Loa Loa (eye worm) hypothetical protein 0.0192 0.7185 0.7183
Loa Loa (eye worm) hypothetical protein 0.0146 0.5387 0.5384
Loa Loa (eye worm) hypothetical protein 0.0016 0.0212 0.0207
Echinococcus multilocularis unc 13 (munc13) 0.0019 0.0333 0.0333
Loa Loa (eye worm) Ras association domain family 1 isoform A 0.0016 0.0212 0.0207
Loa Loa (eye worm) AGC/PKC/IOTA protein kinase 0.0019 0.0298 0.0294
Echinococcus multilocularis myotubularin protein 13 0.0016 0.0212 0.0212
Loa Loa (eye worm) TK/FER protein kinase 0.0013 0.0084 0.0079
Entamoeba histolytica PH domain containing protein kinase, putative 0.0146 0.5387 1
Loa Loa (eye worm) hypothetical protein 0.0013 0.0084 0.0079
Loa Loa (eye worm) TK/FER protein kinase 0.0013 0.0084 0.0079
Entamoeba histolytica hypothetical protein 0.0016 0.0212 0.0242
Echinococcus granulosus C2 calcium dependent membrane targeting 0.0019 0.0333 0.0333
Loa Loa (eye worm) TK/FER protein kinase 0.0013 0.0084 0.0079
Echinococcus multilocularis telomerase reverse transcriptase subunit 0.0048 0.1454 0.1454
Loa Loa (eye worm) hypothetical protein 0.0064 0.2108 0.2104
Echinococcus granulosus tyrosine kinase 0.0048 0.1486 0.1486
Echinococcus granulosus Serine/threonine-protein kinase Genghis Khan 0.0019 0.0298 0.0298
Echinococcus multilocularis cAMP dependent protein kinase catalytic subunit 0.0146 0.5387 0.5387
Entamoeba histolytica protein kinase, putative 0.0025 0.0549 0.0878
Loa Loa (eye worm) hypothetical protein 0.0167 0.6193 0.6192
Loa Loa (eye worm) AGC/RSK/MSK protein kinase 0.0025 0.0549 0.0545
Trichomonas vaginalis AGC family protein kinase 0.0025 0.0549 0.0176
Brugia malayi Variant SH3 domain containing protein 0.0016 0.0202 0.0286
Brugia malayi protein kinase C II. 0.0044 0.1324 0.1917
Echinococcus granulosus insulin receptor 0.0062 0.2008 0.2008
Brugia malayi Protein kinase domain containing protein 0.0025 0.0549 0.0792
Echinococcus granulosus serine:threonine protein kinase N2 0.0025 0.0549 0.0549
Schistosoma mansoni unc-13 (munc13) 0.0019 0.0333 0.0268
Schistosoma mansoni serine/threonine protein kinase 0.0021 0.0412 0.035
Echinococcus granulosus protein kinase c eta type 0.0016 0.0212 0.0212
Echinococcus multilocularis tyrosine kinase 0.0013 0.0084 0.0084
Loa Loa (eye worm) AGC/AKT protein kinase 0.0025 0.0549 0.0545
Echinococcus granulosus guanine nucleotide exchange factor VAV2 0.0025 0.0541 0.0541
Schistosoma mansoni vav2 0.0025 0.0541 0.0485
Echinococcus granulosus protein kinase c epsilon type 0.0044 0.1324 0.1324
Echinococcus granulosus tyrosine protein kinase Fyn 0.0056 0.1803 0.1803
Onchocerca volvulus 0.0019 0.0333 0.0408
Echinococcus granulosus Protein kinase C brain isozyme 0.0092 0.322 0.322
Echinococcus granulosus NDR protein kinase 0.0025 0.0549 0.0549
Entamoeba histolytica protein kinase, putative 0.0025 0.0549 0.0878
Echinococcus granulosus cAMP dependent protein kinase catalytic subunit 0.0146 0.5387 0.5387
Schistosoma mansoni protein kinase C mu 0.0016 0.0212 0.0142
Brugia malayi Hr1 repeat family protein 0.0025 0.0549 0.0792
Loa Loa (eye worm) hypothetical protein 0.0016 0.0202 0.0197
Echinococcus multilocularis cAMP dependent protein kinase catalytic subunit 0.0146 0.5387 0.5387
Loa Loa (eye worm) RasGEF domain-containing protein 0.0016 0.0212 0.0207
Brugia malayi Protein kinase domain containing protein 0.0013 0.0084 0.0115
Loa Loa (eye worm) TK protein kinase 0.004 0.116 0.1156
Echinococcus granulosus proto oncogene tyrosine protein kinase LCK 0.0056 0.1803 0.1803
Loa Loa (eye worm) hypothetical protein 0.0167 0.6193 0.6192
Loa Loa (eye worm) TK protein kinase 0.0048 0.1486 0.1482
Echinococcus multilocularis active breakpoint cluster region 0.0123 0.4465 0.4465
Trypanosoma brucei cAMP-dependent protein kinase catalytic subunit 2 0.0146 0.5387 1

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 6.46 Inhibition of BCR-ABL kinase (unknown origin) ChEMBL. 23473682
IC50 (binding) = 0.18 uM Inhibition of protein kinase C alpha. ChEMBL. No reference
IC50 (binding) = 0.18 uM Inhibition of protein kinase C alpha. ChEMBL. No reference
IC50 (binding) = 0.35 uM Inhibition of v-Abl tyrosine kinase. ChEMBL. No reference
IC50 (binding) = 0.35 uM Inhibition of v-Abl tyrosine kinase. ChEMBL. No reference
IC50 (binding) = 0.5 uM Inhibition of c-Src-tyrosine kinase. ChEMBL. No reference
IC50 (binding) = 0.5 uM Inhibition of c-Src-tyrosine kinase. ChEMBL. No reference
IC50 (binding) = 0.53 uM Inhibition of the epidermal growth factor receptor. ChEMBL. No reference
IC50 (binding) = 0.53 uM Inhibition of the epidermal growth factor receptor. ChEMBL. No reference
IC50 (binding) = 2 uM Inhibition of protein kinase A. ChEMBL. No reference
IC50 (binding) = 2 uM Inhibition of protein kinase A. ChEMBL. No reference
IC50 (binding) = 4.4 uM Inhibition of protein kinase C delta. ChEMBL. No reference
IC50 (binding) = 4.4 uM Inhibition of protein kinase C delta. ChEMBL. No reference
IC50 (binding) = 5 uM Inhibition of the platelet-derived growth factor receptor. ChEMBL. No reference
IC50 (binding) = 5 uM Inhibition of the platelet-derived growth factor receptor. ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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