Detailed information for compound 84071

Basic information

Technical information
  • TDR Targets ID: 84071
  • Name: 3-[(2R,3R)-3-(2,4-difluorophenyl)-3-hydroxy-4 -(1,2,4-triazol-1-yl)butan-2-yl]-7-(1,2,4-tri azol-1-yl)quinazolin-4-one
  • MW: 464.428 | Formula: C22H18F2N8O2
  • H donors: 1 H acceptors: 6 LogP: 1.64 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: Fc1ccc(c(c1)F)[C@]([C@H](n1cnc2c(c1=O)ccc(c2)n1cncn1)C)(Cn1cncn1)O
  • InChi: 1S/C22H18F2N8O2/c1-14(22(34,8-30-11-25-9-28-30)18-5-2-15(23)6-19(18)24)31-13-27-20-7-16(32-12-26-10-29-32)3-4-17(20)21(31)33/h2-7,9-14,34H,8H2,1H3/t14-,22-/m1/s1
  • InChiKey: NAHXGCWBLIBJDW-JLCFBVMHSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 3-[(1R,2R)-2-(2,4-difluorophenyl)-2-hydroxy-1-methyl-3-(1,2,4-triazol-1-yl)propyl]-7-(1,2,4-triazol-1-yl)quinazolin-4-one
  • 3-[(1R,2R)-2-(2,4-difluorophenyl)-2-hydroxy-1-methyl-3-(1,2,4-triazol-1-yl)propyl]-7-(1,2,4-triazol-1-yl)-4-quinazolinone

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Onchocerca volvulus 0.0062 0.018 0.1553
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0131 0.0562 0.0699
Toxoplasma gondii lysine-tRNA ligase 0.0098 0.0378 0.0564
Mycobacterium ulcerans fusion protein of transposase for IS2606 and sialic acid-transport integral membrane protein NanT 0.0062 0.018 0.4129
Brugia malayi Sugar transporter family protein 0.0062 0.018 0.0782
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0037 0.0044 0.0048
Brugia malayi hypothetical protein 0.0062 0.018 0.0782
Loa Loa (eye worm) hypothetical protein 0.0062 0.018 0.0782
Brugia malayi Major Facilitator Superfamily protein 0.0062 0.018 0.0782
Loa Loa (eye worm) hypothetical protein 0.0062 0.018 0.0782
Toxoplasma gondii cell-cycle-associated protein kinase MAPK, putative 0.0708 0.3711 0.5614
Loa Loa (eye worm) latrophilin receptor protein 2 0.0037 0.0044 0.017
Loa Loa (eye worm) hypothetical protein 0.0036 0.0041 0.0159
Echinococcus granulosus General substrate transporter 0.0376 0.19 0.2386
Onchocerca volvulus 0.0235 0.113 1
Loa Loa (eye worm) hypothetical protein 0.0036 0.0041 0.0159
Giardia lamblia Lysyl-tRNA synthetase 0.0098 0.0378 0.5182
Mycobacterium leprae Probable prolyl tRNA synthetase ProS 0.0131 0.0562 1
Onchocerca volvulus 0.0036 0.0041 0.0316
Trichomonas vaginalis sugar transporter, putative 0.0136 0.0586 0.2481
Plasmodium vivax hypothetical protein, conserved 0.0036 0.0041 0.0035
Onchocerca volvulus 0.0062 0.018 0.1553
Onchocerca volvulus 0.0036 0.0041 0.0316
Plasmodium falciparum calcium-dependent protein kinase 5 0.0134 0.0577 0.0404
Trichomonas vaginalis glucose transporter, putative 0.0062 0.018 0.0633
Schistosoma mansoni glucose transport protein 0.0438 0.2237 0.2803
Schistosoma mansoni sugar transporter 0.0062 0.018 0.0219
Schistosoma mansoni hypothetical protein 0.0037 0.0044 0.0048
Plasmodium vivax calcium-dependent protein kinase 1, putative 0.0134 0.0577 0.0571
Trichomonas vaginalis sugar transporter, putative 0.0062 0.018 0.0633
Trypanosoma brucei glucose transporter, putative 0.0136 0.0586 0.8518
Mycobacterium leprae Probable lysyl-tRNA synthase LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase) 0.0083 0.0298 0.4922
Trichomonas vaginalis sugar transporter, putative 0.0062 0.018 0.0633
Trichomonas vaginalis sugar transporter, putative 0.0062 0.018 0.0633
Brugia malayi Calcium/calmodulin-dependent protein kinase type II alpha chain 0.0134 0.0577 0.2558
Onchocerca volvulus 0.0036 0.0041 0.0316
Brugia malayi beta-lactamase family protein 0.0036 0.0041 0.0159
Trichomonas vaginalis conserved hypothetical protein 0.0136 0.0586 0.2481
Brugia malayi Pre-SET motif family protein 0.0207 0.0973 0.4337
Echinococcus multilocularis solute carrier family 22 0.0062 0.018 0.0219
Onchocerca volvulus 0.0062 0.018 0.1553
Trichomonas vaginalis sugar transporter, putative 0.0062 0.018 0.0633
Mycobacterium tuberculosis Probable conserved integral membrane transport protein 0.0062 0.018 0.1306
Trichomonas vaginalis conserved hypothetical protein 0.0062 0.018 0.0633
Brugia malayi Bifunctional aminoacyl-tRNA synthetase 0.0131 0.0562 0.2492
Trypanosoma brucei glucose transporter 2A 0.0136 0.0586 0.8518
Schistosoma mansoni hypothetical protein 0.0071 0.0232 0.0284
Loa Loa (eye worm) hypothetical protein 0.0062 0.018 0.0782
Loa Loa (eye worm) hypothetical protein 0.0062 0.018 0.0782
Loa Loa (eye worm) hypothetical protein 0.0062 0.018 0.0782
Leishmania major glucose transporter, lmgt1 0.0136 0.0586 0.8518
Trichomonas vaginalis sugar transporter, putative 0.0062 0.018 0.0633
Echinococcus granulosus solute carrier family 22 0.0062 0.018 0.0227
Schistosoma mansoni survival motor neuron protein 0.0047 0.0103 0.0122
Trypanosoma brucei sugar transporter, putative 0.0062 0.018 0.2174
Onchocerca volvulus 0.0062 0.018 0.1553
Plasmodium vivax proline--tRNA ligase, putative 0.0153 0.0681 0.0675
Loa Loa (eye worm) hypothetical protein 0.0062 0.018 0.0782
Brugia malayi Sugar transporter family protein 0.0062 0.018 0.0782
Onchocerca volvulus 0.0062 0.018 0.1553
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0134 0.0577 0.0724
Trichomonas vaginalis sugar transporter, putative 0.0062 0.018 0.0633
Trichomonas vaginalis sugar transporter, putative 0.0136 0.0586 0.2481
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.0098 0.0378 0.1533
Trichomonas vaginalis sugar transporter, putative 0.0062 0.018 0.0633
Entamoeba histolytica hypothetical protein 0.0098 0.0378 0.4238
Trypanosoma brucei THT1 - hexose transporter, putative 0.0136 0.0586 0.8518
Onchocerca volvulus Putative transporter 0.0062 0.018 0.1553
Trypanosoma cruzi hexose transporter, putative 0.0136 0.0586 0.8518
Leishmania major protein kinase, putative 0.0134 0.0577 0.8371
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0153 0.0681 1
Trichomonas vaginalis conserved hypothetical protein 0.0062 0.018 0.0633
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0037 0.0044 0.0055
Loa Loa (eye worm) hypothetical protein 0.0062 0.018 0.0782
Trichomonas vaginalis sugar transporter, putative 0.0062 0.018 0.0633
Echinococcus multilocularis General substrate transporter 0.0376 0.19 0.2381
Brugia malayi hypothetical protein 0.0071 0.0232 0.1013
Echinococcus granulosus histone lysine methyltransferase setb 0.003 0.0006 0.0007
Trichomonas vaginalis CAMK family protein kinase 0.0134 0.0577 0.2438
Mycobacterium tuberculosis Lysyl-tRNA synthetase 2 LysX 0.0083 0.0298 0.2407
Brugia malayi Major Facilitator Superfamily protein 0.0062 0.018 0.0782
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0036 0.0041 0.0045
Loa Loa (eye worm) hypothetical protein 0.0134 0.0577 0.2558
Trypanosoma brucei bifunctional aminoacyl-tRNA synthetase, putative 0.0153 0.0681 1
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0438 0.2237 0.2803
Leishmania major glucose transporter, lmgt3 0.0136 0.0586 0.8518
Trichomonas vaginalis prolyl-tRNA synthetase, putative 0.0131 0.0562 0.237
Schistosoma mansoni protein kinase 0.0134 0.0577 0.0717
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0134 0.0577 0.0724
Loa Loa (eye worm) hypothetical protein 0.0062 0.018 0.0782
Trichomonas vaginalis sugar transporter, putative 0.0062 0.018 0.0633
Loa Loa (eye worm) hypothetical protein 0.0062 0.018 0.0782
Mycobacterium ulcerans integral membrane transport protein 0.0062 0.018 0.4129
Leishmania major glucose transporter/membrane transporter D2, putative 0.0136 0.0586 0.8518
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0134 0.0577 0.0717
Mycobacterium tuberculosis Probable dicarboxylic acid transport integral membrane protein KgtP (dicarboxylate transporter) 0.0062 0.018 0.1306
Leishmania major myo-inositol/proton symporter (MIT) 0.0062 0.018 0.2174
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 1 0.0134 0.0577 0.0724
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0438 0.2237 0.2803
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0134 0.0577 0.0724
Loa Loa (eye worm) hypothetical protein 0.0036 0.0041 0.0159
Schistosoma mansoni transcription factor LCR-F1 0.0071 0.0232 0.0284
Trichomonas vaginalis sugar transporter, putative 0.0062 0.018 0.0633
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0207 0.0973 0.4337
Leishmania major lysyl-tRNA synthetase, putative 0.0098 0.0378 0.5265
Trichomonas vaginalis sugar transporter, putative 0.0062 0.018 0.0633
Trypanosoma cruzi lysyl-tRNA synthetase, putative 0.0098 0.0378 0.5265
Echinococcus multilocularis survival motor neuron protein 1 0.0232 0.1113 0.1391
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0047 0.0103 0.0434
Schistosoma mansoni hypothetical protein 0.0037 0.0044 0.0048
Plasmodium vivax calcium-dependent protein kinase 3, putative 0.0134 0.0577 0.0571
Toxoplasma gondii prolyl-tRNA synthetase (ProRS) 0.0153 0.0681 0.1023
Echinococcus granulosus lysyl tRNA synthetase 0.0098 0.0378 0.0475
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0037 0.0044 0.0048
Loa Loa (eye worm) hypothetical protein 0.0037 0.0044 0.017
Onchocerca volvulus 0.0062 0.018 0.1553
Trypanosoma cruzi hexose transporter, putative 0.0136 0.0586 0.8518
Schistosoma mansoni sugar transporter 0.0062 0.018 0.0219
Trypanosoma brucei glucose transporter, putative 0.0136 0.0586 0.8518
Trichomonas vaginalis glucose transporter, putative 0.0136 0.0586 0.2481
Schistosoma mansoni lysyl-tRNA synthetase 0.0098 0.0378 0.0468
Trichomonas vaginalis sugar transporter, putative 0.0062 0.018 0.0633
Plasmodium vivax hexose transporter 0.0438 0.2237 0.2232
Mycobacterium ulcerans prolyl-tRNA synthetase 0.0046 0.0098 0.1667
Loa Loa (eye worm) hypothetical protein 0.0036 0.0041 0.0159
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0037 0.0044 0.0055
Trichomonas vaginalis conserved hypothetical protein 0.0062 0.018 0.0633
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0071 0.0232 0.0284
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0153 0.0681 1
Plasmodium falciparum lysine--tRNA ligase 0.0098 0.0378 0.0201
Loa Loa (eye worm) hypothetical protein 0.0062 0.018 0.0782
Echinococcus multilocularis lysyl tRNA synthetase 0.0098 0.0378 0.0468
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0036 0.0041 0.0159
Echinococcus multilocularis solute carrier family 2, facilitated glucose 0.0438 0.2237 0.2803
Echinococcus multilocularis solute carrier family 22 0.0062 0.018 0.0219
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0134 0.0577 0.0717
Trichomonas vaginalis sugar transporter, putative 0.0062 0.018 0.0633
Trichomonas vaginalis myo-inositol transporter, putative 0.0062 0.018 0.0633
Trypanosoma cruzi hexose transporter, putative 0.0062 0.018 0.2174
Trichomonas vaginalis sugar transporter, putative 0.0062 0.018 0.0633
Loa Loa (eye worm) hypothetical protein 0.0116 0.0476 0.2107
Toxoplasma gondii sugar transporter ST2 0.0062 0.018 0.0264
Loa Loa (eye worm) sugar transporter 0.0062 0.018 0.0782
Trypanosoma cruzi hexose transporter, putative 0.0136 0.0586 0.8518
Plasmodium falciparum calcium-dependent protein kinase 4 0.0134 0.0577 0.0404
Trichomonas vaginalis sugar transporter, putative 0.0062 0.018 0.0633
Trichomonas vaginalis sugar transporter, putative 0.0062 0.018 0.0633
Echinococcus granulosus solute carrier family 22 0.0062 0.018 0.0227
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.0086 0.0312 0.1233
Trypanosoma brucei THT1 - hexose transporter, putative 0.0136 0.0586 0.8518
Plasmodium vivax sugar transporter, putative 0.0062 0.018 0.0175
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0116 0.0476 0.2107
Loa Loa (eye worm) hypothetical protein 0.0232 0.1113 0.4963
Trichomonas vaginalis conserved hypothetical protein 0.0062 0.018 0.0633
Echinococcus multilocularis microtubule associated protein 2 0.1486 0.7964 1
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0098 0.0378 1
Loa Loa (eye worm) hypothetical protein 0.0036 0.0041 0.0159
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0037 0.0044 0.017
Loa Loa (eye worm) hypothetical protein 0.0062 0.018 0.0782
Brugia malayi major facilitator superfamily protein 0.0062 0.018 0.0782
Onchocerca volvulus 0.0062 0.018 0.1553
Trypanosoma brucei myo-inositol/proton symporter (MIT) 0.0062 0.018 0.2174
Trypanosoma brucei glucose transporter, putative 0.0136 0.0586 0.8518
Trichomonas vaginalis set domain proteins, putative 0.0235 0.113 0.4956
Echinococcus granulosus microtubule associated protein 2 0.1486 0.7964 1
Trichomonas vaginalis sugar transporter, putative 0.0062 0.018 0.0633
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0438 0.2237 0.2809
Trypanosoma brucei glucose transporter 1E 0.0136 0.0586 0.8518
Schistosoma mansoni hypothetical protein 0.0047 0.0103 0.0122
Trypanosoma brucei glucose transporter, putative 0.0136 0.0586 0.8518
Brugia malayi Sugar transporter family protein 0.0438 0.2237 1
Loa Loa (eye worm) hypothetical protein 0.0062 0.018 0.0782
Echinococcus granulosus Sugar transporter ERD6 protein 0.0062 0.018 0.0227
Brugia malayi bifunctional aminoacyl-tRNA synthetase 0.0131 0.0562 0.2492
Onchocerca volvulus 0.0062 0.018 0.1553
Entamoeba histolytica protein kinase, putative 0.0134 0.0577 1
Loa Loa (eye worm) hypothetical protein 0.0098 0.0378 0.1668
Toxoplasma gondii sugar transporter ST3 0.0062 0.018 0.0264
Onchocerca volvulus 0.0062 0.018 0.1553
Plasmodium falciparum calcium-dependent protein kinase 1 0.0134 0.0577 0.0404
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0116 0.0476 0.2107
Toxoplasma gondii calcium-dependent protein kinase CDPK2A 0.0134 0.0577 0.0866
Echinococcus granulosus glutamyl tRNA synthetase cytoplasmic 0.0131 0.0562 0.0706
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0438 0.2237 0.2809
Plasmodium falciparum mitogen-activated protein kinase 2 0.0708 0.3711 0.3595
Brugia malayi hypothetical protein 0.0062 0.018 0.0782
Loa Loa (eye worm) major facilitator superfamily transporter 0.0062 0.018 0.0782
Trichomonas vaginalis sugar transporter, putative 0.0062 0.018 0.0633
Plasmodium vivax calcium-dependent protein kinase, putative 0.0134 0.0577 0.0571
Plasmodium falciparum calcium-dependent protein kinase 3 0.0134 0.0577 0.0404
Trichomonas vaginalis sugar transporter, putative 0.0062 0.018 0.0633
Trypanosoma cruzi sugar transporter, putative 0.0062 0.018 0.2174
Loa Loa (eye worm) hypothetical protein 0.0131 0.0562 0.2492
Echinococcus multilocularis glutamyl tRNA synthetase cytoplasmic 0.0131 0.0562 0.0699
Onchocerca volvulus 0.0062 0.018 0.1553
Onchocerca volvulus 0.0062 0.018 0.1553
Schistosoma mansoni protein kinase 0.0134 0.0577 0.0717
Trichomonas vaginalis sugar transporter, putative 0.0136 0.0586 0.2481
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0036 0.0041 0.0045
Trichomonas vaginalis sugar transporter, putative 0.0062 0.018 0.0633
Plasmodium falciparum protein kinase 7 0.1237 0.6605 0.6542
Trichomonas vaginalis sugar transporter, putative 0.0062 0.018 0.0633
Toxoplasma gondii ABC1 family protein 0.0036 0.0041 0.0054
Loa Loa (eye worm) hypothetical protein 0.0131 0.0562 0.2492
Leishmania major hypothetical protein, conserved 0.0062 0.018 0.2174
Mycobacterium tuberculosis Lysyl-tRNA synthetase 1 LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase) 0.0083 0.0298 0.2407
Plasmodium falciparum proline--tRNA ligase 0.0153 0.0681 0.051
Loa Loa (eye worm) bifunctional aminoacyl-tRNA synthetase 0.0054 0.0139 0.0595
Trichomonas vaginalis sugar transporter, putative 0.0062 0.018 0.0633
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0098 0.0378 1
Trichomonas vaginalis sugar transporter, putative 0.0062 0.018 0.0633
Schistosoma mansoni sugar transporter 0.0062 0.018 0.0219
Mycobacterium ulcerans sugar-transport integral membrane protein SugI 0.0062 0.018 0.4129
Echinococcus multilocularis solute carrier family 22 0.0062 0.018 0.0219
Onchocerca volvulus 0.0062 0.018 0.1553
Trichomonas vaginalis conserved hypothetical protein 0.0438 0.2237 1
Loa Loa (eye worm) hypothetical protein 0.0036 0.0041 0.0159
Trichomonas vaginalis sugar transporter, putative 0.0062 0.018 0.0633
Onchocerca volvulus 0.0062 0.018 0.1553
Echinococcus granulosus GPCR family 2 0.0037 0.0044 0.0055
Schistosoma mansoni serine/threonine protein kinase 0.0134 0.0577 0.0717
Schistosoma mansoni glucose transport protein 0.0438 0.2237 0.2803
Loa Loa (eye worm) hypothetical protein 0.0107 0.0427 0.1888
Schistosoma mansoni hypothetical protein 0.0438 0.2237 0.2803
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0153 0.0681 1
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0153 0.0681 1
Echinococcus granulosus solute carrier family 22 0.0062 0.018 0.0227
Trichomonas vaginalis sugar transporter, putative 0.0062 0.018 0.0633
Trichomonas vaginalis sugar transporter, putative 0.0062 0.018 0.0633
Trichomonas vaginalis sugar transporter, putative 0.0062 0.018 0.0633
Wolbachia endosymbiont of Brugia malayi major facilitator superfamily permease 0.0062 0.018 0.5
Brugia malayi latrophilin 2 splice variant baaae 0.0079 0.0276 0.121
Brugia malayi Major Facilitator Superfamily protein 0.0062 0.018 0.0782
Schistosoma mansoni hypothetical protein 0.0037 0.0044 0.0048
Entamoeba histolytica prolyl-tRNA synthetase, putative 0.0131 0.0562 0.957
Onchocerca volvulus 0.0047 0.0103 0.0862
Trypanosoma cruzi hexose transporter 0.0136 0.0586 0.8518
Plasmodium vivax mitogen-activated protein kinase 2, putative 0.0708 0.3711 0.3707
Onchocerca volvulus 0.0062 0.018 0.1553
Plasmodium vivax calcium-dependent protein kinase 4, putative 0.0134 0.0577 0.0571
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0231 0.1106 1
Trypanosoma cruzi glucose transporter, putative 0.0062 0.018 0.2174
Loa Loa (eye worm) hypothetical protein 0.0062 0.018 0.0782
Brugia malayi Cam kinase protein 1 0.0134 0.0577 0.2558
Trichomonas vaginalis sugar transporter, putative 0.0062 0.018 0.0633
Schistosoma mansoni hypothetical protein 0.0079 0.0276 0.0339
Trichomonas vaginalis conserved hypothetical protein 0.0062 0.018 0.0633
Brugia malayi hypothetical protein 0.0232 0.1113 0.4963
Onchocerca volvulus 0.0062 0.018 0.1553
Toxoplasma gondii facilitative glucose transporter GT1 0.0438 0.2237 0.3381
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0071 0.0232 0.0291
Echinococcus multilocularis solute carrier family 22 0.0062 0.018 0.0219
Schistosoma mansoni nuclear transcription factor X-box binding 1 (nfx1) 0.0062 0.018 0.0219
Brugia malayi Latrophilin receptor protein 2 0.0037 0.0044 0.017
Loa Loa (eye worm) calcium/calmodulin-dependent protein kinase ID 0.0134 0.0577 0.2558
Trichomonas vaginalis sugar transporter, putative 0.0062 0.018 0.0633
Schistosoma mansoni lysyl-tRNA synthetase 0.0098 0.0378 0.0468
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0438 0.2237 0.2809
Schistosoma mansoni glucose transport protein 0.0438 0.2237 0.2803
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0036 0.0041 0.0159
Trichomonas vaginalis sugar transporter, putative 0.0062 0.018 0.0633
Plasmodium falciparum hexose transporter 0.0438 0.2237 0.2094
Brugia malayi major facilitator superfamily protein 0.0062 0.018 0.0782
Trichomonas vaginalis sugar transporter, putative 0.0062 0.018 0.0633
Echinococcus multilocularis Sugar transporter ERD6 protein 0.0062 0.018 0.0219
Trichomonas vaginalis sugar transporter, putative 0.0062 0.018 0.0633
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0134 0.0577 0.0717
Onchocerca volvulus 0.0062 0.018 0.1553
Treponema pallidum prolyl-tRNA synthetase 0.0046 0.0098 0.5
Echinococcus multilocularis GPCR, family 2 0.0037 0.0044 0.0048
Plasmodium vivax CDK-related protein kinase 6, putative 0.1858 1 1
Leishmania major glucose transporter, lmgt2 0.0136 0.0586 0.8518
Loa Loa (eye worm) major facilitator superfamily transporter 0.0062 0.018 0.0782
Echinococcus granulosus survival motor neuron protein 1 0.0232 0.1113 0.1398
Echinococcus granulosus calcium dependent protein kinase 0.0126 0.0531 0.0667
Trypanosoma cruzi hexose transporter, putative 0.0074 0.025 0.3256
Plasmodium vivax lysine--tRNA ligase, putative 0.0098 0.0378 0.0372
Trypanosoma brucei glucose transporter, putative 0.0136 0.0586 0.8518
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0438 0.2237 0.2809
Brugia malayi Calcitonin receptor-like protein seb-1 0.0116 0.0476 0.2107
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0134 0.0577 0.0717
Brugia malayi hypothetical protein 0.0062 0.018 0.0782
Trichomonas vaginalis sugar transporter, putative 0.0062 0.018 0.0633
Trypanosoma brucei calcium/calmodulin-dependent protein kinase, putative 0.0134 0.0577 0.8371
Schistosoma mansoni protein kinase 0.0134 0.0577 0.0717
Echinococcus granulosus solute carrier family 22 0.0062 0.018 0.0227
Schistosoma mansoni sugar transporter 0.0062 0.018 0.0219
Plasmodium falciparum calcium-dependent protein kinase 2 0.0134 0.0577 0.0404
Loa Loa (eye worm) CAMK/CAMK2 protein kinase 0.0134 0.0577 0.2558
Loa Loa (eye worm) sugar transporter 0.0438 0.2237 1
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0131 0.0562 0.0699
Chlamydia trachomatis lysine--tRNA ligase 0.0098 0.0378 1
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0438 0.2237 0.2803
Entamoeba histolytica protein kinase, putative 0.0134 0.0577 1
Loa Loa (eye worm) beta-lactamase 0.0036 0.0041 0.0159
Mycobacterium leprae Possible lysyl-tRNA synthetase 2 LysX 0.0098 0.0378 0.6469
Echinococcus multilocularis synaptic vesicle 2 protein 0.0062 0.018 0.0219
Toxoplasma gondii calcium-dependent protein kinase CDPK2B 0.0134 0.0577 0.0866
Trichomonas vaginalis sugar transporter, putative 0.0062 0.018 0.0633
Trypanosoma brucei glucose transporter, putative 0.0136 0.0586 0.8518
Trypanosoma brucei glucose transporter, putative 0.0136 0.0586 0.8518
Trichomonas vaginalis sugar transport protein, putative 0.0062 0.018 0.0633
Brugia malayi beta-lactamase 0.0036 0.0041 0.0159
Loa Loa (eye worm) hypothetical protein 0.0079 0.0276 0.121
Trichomonas vaginalis sugar transporter, putative 0.0062 0.018 0.0633
Toxoplasma gondii sugar transporter ST1 0.0062 0.018 0.0264
Brugia malayi lysyl-tRNA synthetase 0.0098 0.0378 0.1668
Schistosoma mansoni glucose transporter 0.0062 0.018 0.0219
Loa Loa (eye worm) hypothetical protein 0.0062 0.018 0.0782
Schistosoma mansoni microtubule-associated protein tau 0.1486 0.7964 1
Trichomonas vaginalis conserved hypothetical protein 0.0136 0.0586 0.2481
Echinococcus multilocularis beta LACTamase domain containing family member 0.0036 0.0041 0.0045
Echinococcus granulosus synaptic vesicle 2 protein 0.0062 0.018 0.0227
Toxoplasma gondii calcium-dependent protein kinase CDPK3 0.0134 0.0577 0.0866
Loa Loa (eye worm) hypothetical protein 0.0062 0.018 0.0782
Mycobacterium ulcerans sugar transporter 0.0062 0.018 0.4129
Trypanosoma brucei lysyl-tRNA synthetase, putative 0.0098 0.0378 0.5265
Toxoplasma gondii protein kinase, putative 0.1237 0.6605 1
Schistosoma mansoni hypothetical protein 0.0037 0.0044 0.0048
Echinococcus multilocularis calcium dependent protein kinase 0.0126 0.0531 0.066
Toxoplasma gondii transporter, major facilitator family protein 0.0062 0.018 0.0264
Echinococcus granulosus beta LACTamase domain containing family member 0.0036 0.0041 0.0052
Trypanosoma brucei glucose transporter, putative 0.0136 0.0586 0.8518
Trypanosoma brucei THT1 - hexose transporter, putative 0.0136 0.0586 0.8518
Giardia lamblia Prolyl-tRNA synthetase 0.0131 0.0562 1
Brugia malayi beta-lactamase family protein 0.0036 0.0041 0.0159
Trichomonas vaginalis glucose transporter, putative 0.0136 0.0586 0.2481

Activities

Activity type Activity value Assay description Source Reference
MIC (functional) = 6.6 ug ml-1 In vitro for antifungal activity against 10 yeasts ChEMBL. 9599237
MIC (functional) = 80 ug ml-1 In vitro antifungal activity against 6 filamentous fungi ChEMBL. 9599237
Protection (functional) < 50 % In vivo antifungal activity against murine candidosis model after peroral administration with 0.5 mg/kg at various time intervals.(percent protection for 100% mortality with fluconazole-treated group.) ChEMBL. 9599237
Protection (functional) < 50 % In vivo antifungal activity against murine candidosis model after peroral administration with 0.5 mg/kg at various time intervals.(percent protection for 100% mortality with fluconazole-treated group.) ChEMBL. 9599237
Protection (functional) = 70 % In vivo antifungal activity against murine candidosis model after peroral administration with 0.5 mg/kg at various time intervals.(percent protection for 100% mortality with untreated group) ChEMBL. 9599237
Protection (functional) = 70 % In vivo antifungal activity against murine candidosis model after peroral administration with 0.5 mg/kg at various time intervals.(percent protection for 100% mortality with untreated group) ChEMBL. 9599237

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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