Detailed information for compound 84094

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 359.569 | Formula: C22H33NOS
  • H donors: 1 H acceptors: 1 LogP: 5.55 Rotable bonds: 11
    Rule of 5 violations (Lipinski): 1
  • SMILES: C=CC[C@@H](CC/C(=C/C=C/CC/C=C\C1CSC(=N1)[C@@H]1C[C@@H]1C)/C)O
  • InChi: 1S/C22H33NOS/c1-4-10-20(24)14-13-17(2)11-8-6-5-7-9-12-19-16-25-22(23-19)21-15-18(21)3/h4,6,8-9,11-12,18-21,24H,1,5,7,10,13-16H2,2-3H3/b8-6+,12-9-,17-11+/t18-,19?,20-,21+/m0/s1
  • InChiKey: IUPBZPSZHSRUHX-SLRFTDKPSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens tubulin, beta 2B class IIb Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Toxoplasma gondii beta-tubulin, putative Get druggable targets OG5_126611 All targets in OG5_126611
Schistosoma japonicum Tubulin beta-1 chain, putative Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania braziliensis beta-tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Echinococcus multilocularis Tubulin beta 2C chain Get druggable targets OG5_126611 All targets in OG5_126611
Cryptosporidium parvum tubulin beta chain Get druggable targets OG5_126611 All targets in OG5_126611
Schistosoma japonicum Tubulin beta-4 chain, putative Get druggable targets OG5_126611 All targets in OG5_126611
Schistosoma mansoni tubulin subunit beta Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania infantum beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Plasmodium berghei tubulin beta chain, putative Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania major beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Entamoeba histolytica tubulin family protein Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania major beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Neospora caninum hypothetical protein Get druggable targets OG5_126611 All targets in OG5_126611
Entamoeba histolytica tubulin family protein Get druggable targets OG5_126611 All targets in OG5_126611
Neospora caninum hypothetical protein Get druggable targets OG5_126611 All targets in OG5_126611
Brugia malayi beta-tubulin, identical Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania braziliensis beta-tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Loa Loa (eye worm) tubulin beta chain Get druggable targets OG5_126611 All targets in OG5_126611
Echinococcus multilocularis Tubulin beta 2C chain Get druggable targets OG5_126611 All targets in OG5_126611
Echinococcus granulosus Tubulin beta 2C chain Get druggable targets OG5_126611 All targets in OG5_126611
Toxoplasma gondii beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania mexicana beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Loa Loa (eye worm) BEN-1 protein Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania major beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Schistosoma mansoni tubulin subunit beta Get druggable targets OG5_126611 All targets in OG5_126611
Echinococcus multilocularis tubulin, beta 4A class IVa Get druggable targets OG5_126611 All targets in OG5_126611
Echinococcus granulosus Tubulin beta 2C chain Get druggable targets OG5_126611 All targets in OG5_126611
Schistosoma mansoni tubulin subunit beta Get druggable targets OG5_126611 All targets in OG5_126611
Schistosoma mansoni tubulin subunit beta Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania major beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Toxoplasma gondii beta-1 tubulin, putative Get druggable targets OG5_126611 All targets in OG5_126611
Giardia lamblia Beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Trichomonas vaginalis tubulin beta chain, putative Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania major beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Trichomonas vaginalis tubulin gamma chain, putative Get druggable targets OG5_126611 All targets in OG5_126611
Loa Loa (eye worm) tubulin beta-1 chain Get druggable targets OG5_126611 All targets in OG5_126611
Loa Loa (eye worm) BEN-1 protein Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania major beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania major beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Echinococcus granulosus beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania braziliensis beta-tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Schistosoma japonicum Tubulin beta-1 chain, putative Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania major beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Trichomonas vaginalis tubulin alpha chain, putative Get druggable targets OG5_126611 All targets in OG5_126611
Loa Loa (eye worm) tubulin beta-2A chain Get druggable targets OG5_126611 All targets in OG5_126611
Trichomonas vaginalis tubulin epsilon chain, putative Get druggable targets OG5_126611 All targets in OG5_126611
Giardia lamblia Beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Schistosoma mansoni tubulin subunit beta Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania infantum beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Loa Loa (eye worm) beta-tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Echinococcus multilocularis tubulin beta 1 chain Get druggable targets OG5_126611 All targets in OG5_126611
Trypanosoma brucei gambiense beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Echinococcus granulosus Tubulin beta 2C chain Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania infantum beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania major beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Echinococcus granulosus beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Schistosoma japonicum Tubulin beta chain, putative Get druggable targets OG5_126611 All targets in OG5_126611
Babesia bovis tubulin beta chain Get druggable targets OG5_126611 All targets in OG5_126611
Plasmodium yoelii tubulin beta chain Get druggable targets OG5_126611 All targets in OG5_126611
Schistosoma japonicum ko:K07375 tubulin beta, putative Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania major beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Neospora caninum hypothetical protein Get druggable targets OG5_126611 All targets in OG5_126611
Plasmodium vivax tubulin beta chain, putative Get druggable targets OG5_126611 All targets in OG5_126611
Trichomonas vaginalis tubulin, putative Get druggable targets OG5_126611 All targets in OG5_126611
Plasmodium falciparum tubulin beta chain Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania infantum beta-tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Cryptosporidium hominis beta-catenin-like repeat protein Get druggable targets OG5_126611 All targets in OG5_126611
Echinococcus multilocularis Tubulin beta 2C chain Get druggable targets OG5_126611 All targets in OG5_126611
Brugia malayi Tubulin beta-1 chain Get druggable targets OG5_126611 All targets in OG5_126611
Schistosoma japonicum Tubulin beta chain, putative Get druggable targets OG5_126611 All targets in OG5_126611
Echinococcus granulosus Tubulin beta 2C chain Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania major beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania major beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Echinococcus multilocularis Tubulin beta 2C chain Get druggable targets OG5_126611 All targets in OG5_126611
Trypanosoma brucei beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Schistosoma japonicum Tubulin beta chain, putative Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania major beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Echinococcus granulosus tubulin subunit beta Get druggable targets OG5_126611 All targets in OG5_126611
Schistosoma japonicum ko:K07375 tubulin beta, putative Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania braziliensis beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Theileria parva tubulin beta chain, putative Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania major beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Echinococcus granulosus tubulin beta 4A class IVa Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania mexicana beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Schistosoma japonicum Tubulin beta chain, putative Get druggable targets OG5_126611 All targets in OG5_126611
Echinococcus multilocularis beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Trypanosoma cruzi beta tubulin, putative Get druggable targets OG5_126611 All targets in OG5_126611
Echinococcus multilocularis beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Trichomonas vaginalis tubulin epsilon chain, putative Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania major beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania mexicana beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania mexicana beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Echinococcus multilocularis tubulin subunit beta Get druggable targets OG5_126611 All targets in OG5_126611
Trypanosoma brucei gambiense beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Echinococcus granulosus Tubulin beta 2C chain Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania major beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Trypanosoma brucei beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Echinococcus multilocularis Tubulin beta 2C chain Get druggable targets OG5_126611 All targets in OG5_126611
Trypanosoma congolense beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Loa Loa (eye worm) tubulin beta-4 chain Get druggable targets OG5_126611 All targets in OG5_126611
Schistosoma mansoni tubulin subunit beta Get druggable targets OG5_126611 All targets in OG5_126611
Trypanosoma brucei beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Echinococcus granulosus tubulin beta 1 chain Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania major beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania mexicana Get druggable targets OG5_126611 All targets in OG5_126611
Schistosoma japonicum Tubulin beta-7 chain, putative Get druggable targets OG5_126611 All targets in OG5_126611
Trypanosoma brucei beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania major beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Giardia lamblia Beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Plasmodium falciparum tubulin gamma chain tubulin, beta 2B class IIb 445 aa 438 aa 32.9 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma cruzi hexose transporter, putative 0.0062 0.015 0.3018
Onchocerca volvulus 0.0062 0.015 1
Echinococcus granulosus solute carrier family 22 0.0062 0.015 0.015
Trichomonas vaginalis sugar transporter, putative 0.0062 0.015 0.0786
Trichomonas vaginalis sugar transport protein, putative 0.0062 0.015 0.0786
Loa Loa (eye worm) sugar transporter 0.0062 0.015 0.0786
Trichomonas vaginalis glucose transporter, putative 0.0137 0.0496 0.2603
Brugia malayi Cache domain containing protein 0.0443 0.1904 0.9996
Trypanosoma brucei glucose transporter, putative 0.0137 0.0496 1
Wolbachia endosymbiont of Brugia malayi major facilitator superfamily permease 0.0062 0.015 0.5
Trypanosoma brucei glucose transporter 2A 0.0137 0.0496 1
Plasmodium vivax circumsporozoite- and TRAP-related protein, putative 0.0041 0.0051 0.0267
Trichomonas vaginalis sugar transporter, putative 0.0062 0.015 0.0786
Trichomonas vaginalis sugar transporter, putative 0.0062 0.015 0.0786
Loa Loa (eye worm) hypothetical protein 0.0132 0.0473 0.2485
Plasmodium falciparum thrombospondin-related anonymous protein 0.0041 0.0051 0.0267
Brugia malayi von Willebrand factor type A domain containing protein 0.0041 0.0051 0.0267
Onchocerca volvulus 0.0062 0.015 1
Trichomonas vaginalis sugar transporter, putative 0.0062 0.015 0.0786
Trichomonas vaginalis sugar transporter, putative 0.0062 0.015 0.0786
Brugia malayi Sugar transporter family protein 0.0062 0.015 0.0786
Trypanosoma cruzi hexose transporter, putative 0.0075 0.0209 0.4209
Brugia malayi Major Facilitator Superfamily protein 0.0062 0.015 0.0786
Trichomonas vaginalis sugar transporter, putative 0.0062 0.015 0.0786
Echinococcus granulosus Sugar transporter ERD6 protein 0.0062 0.015 0.015
Echinococcus multilocularis General substrate transporter 0.0381 0.1617 0.1617
Trichomonas vaginalis sugar transporter, putative 0.0137 0.0496 0.2603
Plasmodium vivax thrombospondin-related anonymous protein 0.0041 0.0051 0.0267
Onchocerca volvulus 0.0062 0.015 1
Brugia malayi hypothetical protein 0.0062 0.015 0.0786
Brugia malayi Major Facilitator Superfamily protein 0.0062 0.015 0.0786
Mycobacterium tuberculosis Probable conserved integral membrane transport protein 0.0062 0.015 0.5
Schistosoma mansoni hypothetical protein 0.0041 0.0051 0.0119
Trichomonas vaginalis sugar transporter, putative 0.0062 0.015 0.0786
Trichomonas vaginalis sugar transporter, putative 0.0062 0.015 0.0786
Schistosoma mansoni hypothetical protein 0.0516 0.2244 0.5237
Loa Loa (eye worm) hypothetical protein 0.0041 0.0051 0.0267
Plasmodium falciparum von Willebrand factor A domain-related protein 0.0041 0.0051 0.0267
Loa Loa (eye worm) hypothetical protein 0.0062 0.015 0.0786
Trichomonas vaginalis conserved hypothetical protein 0.0062 0.015 0.0786
Treponema pallidum hypothetical protein 0.0041 0.0051 0.5
Brugia malayi von Willebrand factor type A domain containing protein 0.0041 0.0051 0.0267
Plasmodium vivax hypothetical protein, conserved 0.0041 0.0051 0.0267
Trypanosoma cruzi hexose transporter, putative 0.0137 0.0496 1
Trypanosoma brucei glucose transporter, putative 0.0137 0.0496 1
Schistosoma mansoni biogenic amine (5HT) receptor 0.0132 0.0473 0.1104
Schistosoma mansoni sugar transporter 0.0062 0.015 0.0349
Plasmodium vivax hexose transporter 0.0443 0.1904 1
Trichomonas vaginalis glucose transporter, putative 0.0137 0.0496 0.2603
Echinococcus granulosus voltage dependent calcium channel subunit 0.1 0.4473 0.4473
Brugia malayi von Willebrand factor type A domain containing protein 0.0041 0.0051 0.0267
Leishmania major myo-inositol/proton symporter (MIT) 0.0062 0.015 0.3018
Trypanosoma cruzi hexose transporter, putative 0.0137 0.0496 1
Leishmania major glucose transporter, lmgt2 0.0137 0.0496 1
Trypanosoma brucei myo-inositol/proton symporter (MIT) 0.0062 0.015 0.3018
Brugia malayi major facilitator superfamily protein 0.0062 0.015 0.0786
Mycobacterium ulcerans integral membrane transport protein 0.0062 0.015 0.5
Loa Loa (eye worm) hypothetical protein 0.0062 0.015 0.0786
Trichomonas vaginalis sugar transporter, putative 0.0062 0.015 0.0786
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0443 0.1904 0.1904
Loa Loa (eye worm) hypothetical protein 0.0041 0.0051 0.0267
Loa Loa (eye worm) hypothetical protein 0.0041 0.0051 0.0267
Loa Loa (eye worm) major facilitator superfamily transporter 0.0062 0.015 0.0786
Trypanosoma cruzi hexose transporter 0.0137 0.0496 1
Loa Loa (eye worm) hypothetical protein 0.0031 0.0006 0.0033
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0443 0.1904 0.1904
Mycobacterium ulcerans sugar transporter 0.0062 0.015 0.5
Loa Loa (eye worm) hypothetical protein 0.0062 0.015 0.0786
Loa Loa (eye worm) major facilitator superfamily transporter 0.0062 0.015 0.0786
Loa Loa (eye worm) hypothetical protein 0.0062 0.015 0.0786
Onchocerca volvulus 0.0062 0.015 1
Onchocerca volvulus 0.0062 0.015 1
Onchocerca volvulus 0.0062 0.015 1
Loa Loa (eye worm) von Willebrand factor domain-containing protein 0.0041 0.0051 0.0267
Toxoplasma gondii sugar transporter ST1 0.0062 0.015 0.0786
Toxoplasma gondii microneme protein MIC2 0.0041 0.0051 0.0267
Echinococcus granulosus solute carrier family 22 0.0062 0.015 0.015
Brugia malayi Sugar transporter family protein 0.0062 0.015 0.0786
Schistosoma mansoni voltage-gated potassium channel 0.0039 0.0043 0.0101
Onchocerca volvulus 0.0062 0.015 1
Trichomonas vaginalis sugar transporter, putative 0.0062 0.015 0.0786
Echinococcus multilocularis serotonin receptor 0.0132 0.0473 0.0473
Trichomonas vaginalis sugar transporter, putative 0.0062 0.015 0.0786
Trichomonas vaginalis sugar transporter, putative 0.0062 0.015 0.0786
Trichomonas vaginalis sugar transporter, putative 0.0062 0.015 0.0786
Leishmania major glucose transporter, lmgt3 0.0137 0.0496 1
Trichomonas vaginalis sugar transporter, putative 0.0137 0.0496 0.2603
Brugia malayi Sugar transporter family protein 0.0443 0.1904 1
Onchocerca volvulus 0.0062 0.015 1
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0034 0.0017 0.009
Trypanosoma brucei THT1 - hexose transporter, putative 0.0137 0.0496 1
Echinococcus multilocularis voltage dependent calcium channel subunit 0.1 0.4473 0.4473
Trichomonas vaginalis glucose transporter, putative 0.0062 0.015 0.0786
Trypanosoma brucei sugar transporter, putative 0.0062 0.015 0.3018
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0443 0.1904 0.1904
Trichomonas vaginalis sugar transporter, putative 0.0062 0.015 0.0786
Trypanosoma brucei glucose transporter, putative 0.0137 0.0496 1
Loa Loa (eye worm) hypothetical protein 0.0062 0.015 0.0786
Onchocerca volvulus Putative transporter 0.0062 0.015 1
Loa Loa (eye worm) CUTiclin family member 0.0041 0.0051 0.0267
Treponema pallidum 76K protein 0.0041 0.0051 0.5
Leishmania major hypothetical protein, conserved 0.0062 0.015 0.3018
Mycobacterium ulcerans sugar-transport integral membrane protein SugI 0.0062 0.015 0.5
Trichomonas vaginalis sugar transporter, putative 0.0062 0.015 0.0786
Echinococcus multilocularis solute carrier family 22 0.0062 0.015 0.015
Entamoeba histolytica hypothetical protein, conserved 0.0041 0.0051 1
Brugia malayi Zona pellucida-like domain containing protein 0.0041 0.0051 0.0267
Schistosoma mansoni dihydropyridine-sensitive l-type calcium channel 0.0483 0.2092 0.4882
Onchocerca volvulus 0.0062 0.015 1
Trypanosoma brucei glucose transporter, putative 0.0137 0.0496 1
Trichomonas vaginalis sugar transporter, putative 0.0062 0.015 0.0786
Loa Loa (eye worm) hypothetical protein 0.0041 0.0051 0.0267
Trichomonas vaginalis sugar transporter, putative 0.0062 0.015 0.0786
Loa Loa (eye worm) hypothetical protein 0.0041 0.0051 0.0267
Onchocerca volvulus 0.0062 0.015 1
Trichomonas vaginalis sugar transporter, putative 0.0062 0.015 0.0786
Schistosoma mansoni hypothetical protein 0.0041 0.0051 0.0119
Schistosoma mansoni sugar transporter 0.0062 0.015 0.0349
Echinococcus multilocularis solute carrier family 2, facilitated glucose 0.0443 0.1904 0.1904
Trichomonas vaginalis conserved hypothetical protein 0.0062 0.015 0.0786
Entamoeba histolytica elongation factor-2 kinase, putative 0.0041 0.0051 1
Onchocerca volvulus 0.0062 0.015 1
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0036 0.0028 0.0028
Trypanosoma brucei THT1 - hexose transporter, putative 0.0137 0.0496 1
Trypanosoma brucei glucose transporter, putative 0.0137 0.0496 1
Loa Loa (eye worm) hypothetical protein 0.0041 0.0051 0.0267
Trichomonas vaginalis myo-inositol transporter, putative 0.0062 0.015 0.0786
Trichomonas vaginalis sugar transporter, putative 0.0062 0.015 0.0786
Trichomonas vaginalis conserved hypothetical protein 0.0137 0.0496 0.2603
Schistosoma mansoni glucose transporter 0.0062 0.015 0.0349
Echinococcus granulosus solute carrier family 22 0.0062 0.015 0.015
Trichomonas vaginalis sugar transporter, putative 0.0062 0.015 0.0786
Leishmania major glucose transporter, lmgt1 0.0137 0.0496 1
Toxoplasma gondii facilitative glucose transporter GT1 0.0443 0.1904 1
Schistosoma mansoni glucose transport protein 0.0443 0.1904 0.4444
Leishmania major glucose transporter/membrane transporter D2, putative 0.0137 0.0496 1
Trichomonas vaginalis sugar transporter, putative 0.0062 0.015 0.0786
Trichomonas vaginalis sugar transporter, putative 0.0062 0.015 0.0786
Trichomonas vaginalis sugar transporter, putative 0.0062 0.015 0.0786
Loa Loa (eye worm) CUTiclin-Like family member 0.0041 0.0051 0.0267
Trichomonas vaginalis conserved hypothetical protein 0.0062 0.015 0.0786
Brugia malayi von Willebrand factor type A domain containing protein 0.0041 0.0051 0.0267
Loa Loa (eye worm) hypothetical protein 0.0062 0.015 0.0786
Trichomonas vaginalis sugar transporter, putative 0.0062 0.015 0.0786
Plasmodium falciparum major facilitator superfamily domain-containing protein, putative 0.0062 0.015 0.0786
Echinococcus granulosus collagen alpha 1VII chain 0.0041 0.0051 0.0051
Loa Loa (eye worm) hypothetical protein 0.0041 0.0051 0.0267
Trichomonas vaginalis sugar transporter, putative 0.0137 0.0496 0.2603
Trypanosoma cruzi glucose transporter, putative 0.0062 0.015 0.3018
Loa Loa (eye worm) hypothetical protein 0.0041 0.0051 0.0267
Mycobacterium tuberculosis Probable dicarboxylic acid transport integral membrane protein KgtP (dicarboxylate transporter) 0.0062 0.015 0.5
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0443 0.1904 0.1904
Echinococcus multilocularis synaptic vesicle 2 protein 0.0062 0.015 0.015
Trypanosoma cruzi sugar transporter, putative 0.0062 0.015 0.3018
Trypanosoma brucei glucose transporter, putative 0.0137 0.0496 1
Loa Loa (eye worm) hypothetical protein 0.0062 0.015 0.0786
Onchocerca volvulus 0.0062 0.015 1
Brugia malayi von Willebrand factor type A domain containing protein 0.0041 0.0051 0.0267
Toxoplasma gondii sugar transporter ST3 0.0062 0.015 0.0786
Echinococcus multilocularis Sugar transporter ERD6 protein 0.0062 0.015 0.015
Loa Loa (eye worm) hypothetical protein 0.0041 0.0051 0.0267
Trichomonas vaginalis sugar transporter, putative 0.0062 0.015 0.0786
Trichomonas vaginalis sugar transporter, putative 0.0062 0.015 0.0786
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.0036 0.0028 0.0147
Plasmodium falciparum circumsporozoite- and TRAP-related protein 0.0041 0.0051 0.0267
Loa Loa (eye worm) hypothetical protein 0.0062 0.015 0.0786
Trichomonas vaginalis sugar transporter, putative 0.0062 0.015 0.0786
Toxoplasma gondii transporter, major facilitator family protein 0.0062 0.015 0.0786
Loa Loa (eye worm) hypothetical protein 0.0443 0.1904 0.9996
Brugia malayi Transmembrane cell adhesion receptor mua-3 precursor, putative 0.0041 0.0051 0.0267
Trichomonas vaginalis sugar transporter, putative 0.0062 0.015 0.0786
Brugia malayi von Willebrand factor type A domain containing protein 0.0041 0.0051 0.0267
Trichomonas vaginalis sugar transporter, putative 0.0062 0.015 0.0786
Schistosoma mansoni nuclear transcription factor X-box binding 1 (nfx1) 0.0062 0.015 0.0349
Trypanosoma brucei glucose transporter, putative 0.0137 0.0496 1
Plasmodium falciparum hexose transporter 0.0443 0.1904 1
Schistosoma mansoni glucose transport protein 0.0443 0.1904 0.4444
Toxoplasma gondii von Willebrand factor type A domain-containing protein 0.0041 0.0051 0.0267
Trichomonas vaginalis sugar transporter, putative 0.0062 0.015 0.0786
Loa Loa (eye worm) hypothetical protein 0.0041 0.0051 0.0267
Brugia malayi Zona pellucida-like domain containing protein 0.0041 0.0051 0.0267
Loa Loa (eye worm) von Willebrand factor type A domain-containing protein 0.0041 0.0051 0.0267
Onchocerca volvulus 0.0062 0.015 1
Trichomonas vaginalis sugar transporter, putative 0.0062 0.015 0.0786
Brugia malayi hypothetical protein 0.0062 0.015 0.0786
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0443 0.1904 0.1904
Echinococcus granulosus synaptic vesicle 2 protein 0.0062 0.015 0.015
Loa Loa (eye worm) hypothetical protein 0.0132 0.0473 0.2485
Trichomonas vaginalis sugar transporter, putative 0.0062 0.015 0.0786
Brugia malayi Major Facilitator Superfamily protein 0.0062 0.015 0.0786
Schistosoma mansoni voltage-gated potassium channel 0.0039 0.0043 0.0101
Giardia lamblia Sugar-proton symporter 0.0062 0.015 1
Brugia malayi von Willebrand factor type A domain containing protein 0.0041 0.0051 0.0267
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0036 0.0028 0.0028
Loa Loa (eye worm) hypothetical protein 0.0062 0.015 0.0786
Echinococcus granulosus biogenic amine 5HT receptor 0.0132 0.0473 0.0473
Trichomonas vaginalis sugar transporter, putative 0.0062 0.015 0.0786
Schistosoma mansoni glucose transport protein 0.0443 0.1904 0.4444
Plasmodium vivax dynein-related AAA-type ATPase, putative 0.0041 0.0051 0.0267
Trichomonas vaginalis conserved hypothetical protein 0.0062 0.015 0.0786
Brugia malayi Immunoglobulin I-set domain containing protein 0.0041 0.0051 0.0267
Loa Loa (eye worm) hypothetical protein 0.0062 0.015 0.0786
Echinococcus multilocularis solute carrier family 22 0.0062 0.015 0.015
Loa Loa (eye worm) hypothetical protein 0.0041 0.0051 0.0267
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0443 0.1904 0.1904
Echinococcus multilocularis collagen alpha 1(VII) chain 0.0041 0.0051 0.0051
Brugia malayi von Willebrand factor type A domain containing protein 0.0041 0.0051 0.0267
Brugia malayi major facilitator superfamily protein 0.0062 0.015 0.0786
Brugia malayi von Willebrand Factor 0.0041 0.0051 0.0267
Schistosoma mansoni sugar transporter 0.0062 0.015 0.0349
Loa Loa (eye worm) hypothetical protein 0.0062 0.015 0.0786
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0443 0.1904 0.1904
Schistosoma mansoni hypothetical protein 0.0443 0.1904 0.4444
Brugia malayi hypothetical protein 0.0062 0.015 0.0786
Trypanosoma brucei glucose transporter 1E 0.0137 0.0496 1
Trichomonas vaginalis sugar transporter, putative 0.0062 0.015 0.0786
Loa Loa (eye worm) hypothetical protein 0.0041 0.0051 0.0267
Trichomonas vaginalis conserved hypothetical protein 0.0062 0.015 0.0786
Trypanosoma brucei THT1 - hexose transporter, putative 0.0137 0.0496 1
Echinococcus granulosus General substrate transporter 0.0381 0.1617 0.1617
Onchocerca volvulus 0.0062 0.015 1
Trypanosoma brucei glucose transporter, putative 0.0137 0.0496 1
Toxoplasma gondii sugar transporter ST2 0.0062 0.015 0.0786
Plasmodium vivax von Willebrand factor A domain-related protein, putative 0.0041 0.0051 0.0267
Echinococcus multilocularis voltage dependent calcium channel subunit 0.2198 1 1
Loa Loa (eye worm) hypothetical protein 0.0062 0.015 0.0786
Trichomonas vaginalis sugar transporter, putative 0.0062 0.015 0.0786
Echinococcus granulosus solute carrier family 22 0.0062 0.015 0.015
Loa Loa (eye worm) sugar transporter 0.0443 0.1904 1
Giardia lamblia Hexose transporter 0.0062 0.015 1
Onchocerca volvulus 0.0062 0.015 1
Loa Loa (eye worm) hypothetical protein 0.0062 0.015 0.0786
Onchocerca volvulus 0.0062 0.015 1
Trypanosoma cruzi hexose transporter, putative 0.0137 0.0496 1
Schistosoma mansoni serine-rich repeat protein 0.0516 0.2244 0.5237
Entamoeba histolytica hypothetical protein 0.0041 0.0051 1
Schistosoma mansoni dihydropyridine-sensitive l-type calcium channel 0.0959 0.4285 1
Loa Loa (eye worm) hypothetical protein 0.0041 0.0051 0.0267
Trichomonas vaginalis ubiquitin-conjugating enzyme E2, putative 0.0041 0.0051 0.0267
Trichomonas vaginalis conserved hypothetical protein 0.0137 0.0496 0.2603
Echinococcus multilocularis solute carrier family 22 0.0062 0.015 0.015
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.0036 0.0028 0.0147
Loa Loa (eye worm) hypothetical protein 0.0062 0.015 0.0786
Trichomonas vaginalis conserved hypothetical protein 0.0443 0.1904 1
Loa Loa (eye worm) hypothetical protein 0.0062 0.015 0.0786
Loa Loa (eye worm) hypothetical protein 0.0041 0.0051 0.0267
Echinococcus multilocularis serotonin receptor 0.0132 0.0473 0.0473
Schistosoma mansoni sugar transporter 0.0062 0.015 0.0349
Mycobacterium ulcerans fusion protein of transposase for IS2606 and sialic acid-transport integral membrane protein NanT 0.0062 0.015 0.5
Echinococcus multilocularis solute carrier family 22 0.0062 0.015 0.015
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0034 0.0017 0.009
Entamoeba histolytica hypothetical protein, conserved 0.0041 0.0051 1
Plasmodium vivax sugar transporter, putative 0.0062 0.015 0.0786
Brugia malayi hypothetical protein 0.0041 0.0051 0.0267

Activities

Activity type Activity value Assay description Source Reference
GI50 (functional) = 0.45 uM Tested for 50% growth inhibitory concentration by using MCF-7 cell lines. ChEMBL. 11960501
GI50 (functional) = 0.45 uM Tested for 50% growth inhibitory concentration by using MCF-7 cell lines. ChEMBL. 11960501
IC50 (functional) = 0.87 uM Inhibition of tubulin polymerization in human ovarian cancer cell lines ChEMBL. 11960501
IC50 (functional) = 0.87 uM Inhibition of tubulin polymerization in human ovarian cancer cell lines ChEMBL. 11960501
Inhibition (functional) = 82 % Tested for colchicine binding inhibition, using human ovarian cancer cell lines (at 5 microM ) ChEMBL. 11960501
Inhibition (functional) = 82 % Tested for colchicine binding inhibition, using human ovarian cancer cell lines (at 5 microM ) ChEMBL. 11960501

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

No external resources registered for this compound

Bibliographic References

1 literature reference was collected for this gene.

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