Detailed information for compound 843517

Basic information

Technical information
  • TDR Targets ID: 843517
  • Name: 2-[6-(diethylsulfamoyl)-3-oxo-1,4-benzothiazi n-4-yl]-N-propylacetamide
  • MW: 399.528 | Formula: C17H25N3O4S2
  • H donors: 1 H acceptors: 4 LogP: 1.72 Rotable bonds: 9
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCCNC(=O)CN1C(=O)CSc2c1cc(cc2)S(=O)(=O)N(CC)CC
  • InChi: 1S/C17H25N3O4S2/c1-4-9-18-16(21)11-20-14-10-13(26(23,24)19(5-2)6-3)7-8-15(14)25-12-17(20)22/h7-8,10H,4-6,9,11-12H2,1-3H3,(H,18,21)
  • InChiKey: OHIPPZWSSAHOAS-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 2-[6-(diethylsulfamoyl)-3-oxo-1,4-benzothiazin-4-yl]-N-propyl-acetamide
  • 2-[6-(diethylsulfamoyl)-3-keto-1,4-benzothiazin-4-yl]-N-propyl-acetamide
  • 2-[6-(diethylsulfamoyl)-3-oxo-1,4-benzothiazin-4-yl]-N-propyl-ethanamide

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) carboxylesterase 0.0036 0.0494 0.0966
Loa Loa (eye worm) hypothetical protein 0.0026 0.0248 0.0485
Loa Loa (eye worm) hypothetical protein 0.0017 0.0041 0.0079
Schistosoma mansoni chondroitin sulfate proteoglycan-related 0.0026 0.0248 0.0248
Loa Loa (eye worm) hypothetical protein 0.002 0.0104 0.0204
Loa Loa (eye worm) hypothetical protein 0.0017 0.0041 0.0079
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0082 0.6513
Schistosoma mansoni cathepsin D (A01 family) 0.0017 0.0041 0.0041
Loa Loa (eye worm) hypothetical protein 0.002 0.0104 0.0204
Schistosoma mansoni cathepsin D (A01 family) 0.0017 0.0041 0.0041
Loa Loa (eye worm) carboxylesterase 0.0211 0.4771 0.9339
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0019 0.0082 0.5
Brugia malayi hypothetical protein 0.002 0.0104 0.0204
Brugia malayi Carboxylesterase family protein 0.0036 0.0494 0.0966
Echinococcus granulosus acetylcholinesterase 0.0211 0.4771 0.5762
Brugia malayi aspartic protease BmAsp-2, identical 0.0017 0.0041 0.0079
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0017 0.0041 0.0041
Onchocerca volvulus 0.0048 0.0795 1
Echinococcus granulosus pikachurin 0.0026 0.0248 0.0299
Loa Loa (eye worm) hypothetical protein 0.0036 0.0494 0.0966
Echinococcus granulosus neurogenic locus notch protein 0.0026 0.0248 0.0299
Brugia malayi hypothetical protein 0.0036 0.0494 0.0966
Brugia malayi hypothetical protein 0.0017 0.0041 0.0079
Echinococcus multilocularis RUN 0.002 0.0104 0.0126
Schistosoma mansoni hypothetical protein 0.002 0.0104 0.0104
Loa Loa (eye worm) hypothetical protein 0.0017 0.0041 0.0079
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0036 0.0494 0.0494
Echinococcus multilocularis lipoxygenase domain containing protein 0.002 0.0104 0.0126
Echinococcus granulosus acetylcholinesterase 0.0211 0.4771 0.5762
Schistosoma mansoni loxhd1 0.002 0.0104 0.0104
Echinococcus multilocularis geminin 0.0356 0.828 1
Echinococcus granulosus carboxylesterase 5A 0.0211 0.4771 0.5762
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0019 0.0082 0.5
Echinococcus multilocularis acetylcholinesterase 0.0211 0.4771 0.5762
Loa Loa (eye worm) hypothetical protein 0.0026 0.0248 0.0485
Schistosoma mansoni gliotactin 0.0036 0.0494 0.0494
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0019 0.0082 0.016
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0082 0.6513
Schistosoma mansoni rab6-interacting 0.002 0.0104 0.0104
Brugia malayi Carboxylesterase family protein 0.0211 0.4771 0.9339
Echinococcus granulosus RUN 0.002 0.0104 0.0126
Onchocerca volvulus 0.0036 0.0494 0.6207
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0017 0.0041 0.0041
Loa Loa (eye worm) hypothetical protein 0.0036 0.0494 0.0966
Loa Loa (eye worm) aspartic protease BmAsp-1 0.0017 0.0041 0.0079
Echinococcus multilocularis tumor protein p63 0.0329 0.7626 0.921
Loa Loa (eye worm) acetylcholinesterase 1 0.0211 0.4771 0.9339
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0019 0.0082 0.5
Loa Loa (eye worm) hypothetical protein 0.0036 0.0494 0.0966
Loa Loa (eye worm) aspartic protease BmAsp-2 0.0017 0.0041 0.0079
Echinococcus multilocularis BC026374 protein (S09 family) 0.0036 0.0494 0.0596
Brugia malayi Doublecortin family protein 0.002 0.0104 0.0204
Trichomonas vaginalis spcc417.12 protein, putative 0.0036 0.0494 1
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0082 0.0914
Plasmodium falciparum LCCL domain-containing protein 0.002 0.0104 1
Schistosoma mansoni ap endonuclease 0.0019 0.0082 0.0082
Echinococcus granulosus tumor protein p63 0.0329 0.7626 0.921
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0017 0.0041 0.0041
Schistosoma mansoni hypothetical protein 0.0356 0.828 0.828
Loa Loa (eye worm) hypothetical protein 0.0211 0.4771 0.9339
Loa Loa (eye worm) hypothetical protein 0.0026 0.0248 0.0485
Loa Loa (eye worm) hypothetical protein 0.0211 0.4771 0.9339
Onchocerca volvulus 0.0036 0.0494 0.6207
Echinococcus multilocularis neurogenic locus notch protein 0.0026 0.0248 0.0299
Brugia malayi Thrombospondin N-terminal -like domain containing protein 0.0026 0.0248 0.0485
Brugia malayi Carboxylesterase family protein 0.0036 0.0494 0.0966
Loa Loa (eye worm) hypothetical protein 0.0036 0.0494 0.0966
Onchocerca volvulus 0.002 0.0104 0.131
Onchocerca volvulus 0.0017 0.0041 0.051
Echinococcus granulosus neuroligin 0.0036 0.0494 0.0596
Schistosoma mansoni slit 0.0026 0.0248 0.0248
Schistosoma mansoni laminin gamma-3 chain 0.0026 0.0248 0.0248
Brugia malayi Eukaryotic aspartyl protease family protein 0.0017 0.0041 0.0079
Echinococcus multilocularis acetylcholinesterase 0.0211 0.4771 0.5762
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0055 0.0969 0.117
Schistosoma mansoni BC026374 protein (S09 family) 0.0036 0.0494 0.0494
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0225 0.5109 1
Brugia malayi exodeoxyribonuclease III family protein 0.0019 0.0082 0.016
Echinococcus multilocularis lipoxygenase domain containing protein 0.002 0.0104 0.0126
Mycobacterium ulcerans carboxylesterase, LipT 0.0036 0.0494 1
Echinococcus granulosus slit 2 protein 0.0026 0.0248 0.0299
Brugia malayi Pepsin A precursor 0.0017 0.0041 0.0079
Brugia malayi hypothetical protein 0.0017 0.0041 0.0079
Brugia malayi follicle stimulating hormone receptor 0.0225 0.5109 1
Brugia malayi Carboxylesterase family protein 0.0211 0.4771 0.9339
Echinococcus multilocularis slit 2 protein 0.0026 0.0248 0.0299
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0036 0.0494 0.0494
Echinococcus multilocularis family S9 non peptidase ue (S09 family) 0.0036 0.0494 0.0596
Loa Loa (eye worm) abnormal epIthelia family member 0.0026 0.0248 0.0485
Echinococcus multilocularis para nitrobenzyl esterase 0.0036 0.0494 0.0596
Echinococcus granulosus family S9 non peptidase ue S09 family 0.0036 0.0494 0.0596
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0019 0.0082 0.0099
Treponema pallidum exodeoxyribonuclease (exoA) 0.0019 0.0082 0.5
Brugia malayi laminin-like protein K08C7.3 precursor 0.0026 0.0248 0.0485
Schistosoma mansoni lipoxygenase 0.002 0.0104 0.0104
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0211 0.4771 0.4771
Echinococcus granulosus geminin 0.0356 0.828 1
Schistosoma mansoni ap endonuclease 0.0019 0.0082 0.0082
Echinococcus granulosus Polycystic kidney disease protein 0.002 0.0104 0.0126
Loa Loa (eye worm) hypothetical protein 0.0048 0.0795 0.1556
Mycobacterium tuberculosis Carboxylesterase LipT 0.0036 0.0494 1
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0019 0.0082 0.5
Toxoplasma gondii exonuclease III APE 0.0019 0.0082 1
Loa Loa (eye worm) carboxylesterase 0.0036 0.0494 0.0966
Brugia malayi Carboxylesterase family protein 0.0036 0.0494 0.0966
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0019 0.0082 0.5
Loa Loa (eye worm) hypothetical protein 0.0036 0.0494 0.0966
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.0036 0.0494 1
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0019 0.0082 0.5
Echinococcus multilocularis cathepsin d (lysosomal aspartyl protease) 0.0017 0.0041 0.0049
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0017 0.0041 0.0041
Schistosoma mansoni neuroligin 3 (S09 family) 0.0036 0.0494 0.0494
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0019 0.0082 0.0099
Loa Loa (eye worm) hypothetical protein 0.0036 0.0494 0.0966
Echinococcus multilocularis pikachurin 0.0026 0.0248 0.0299
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0017 0.0041 0.0041
Loa Loa (eye worm) aspartyl protease 6 0.0017 0.0041 0.0079
Schistosoma mansoni acetylcholinesterase 0.0036 0.0494 0.0494
Brugia malayi laminin alpha chain 0.0026 0.0248 0.0485
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0036 0.0494 0.0494
Echinococcus multilocularis neuroligin 0.0036 0.0494 0.0596
Plasmodium vivax multidomain scavenger receptor, putative 0.002 0.0104 1
Echinococcus granulosus lipoxygenase domain containing protein 0.002 0.0104 0.0126
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0055 0.0969 0.117
Brugia malayi EGF-like domain containing protein 0.0026 0.0248 0.0485
Echinococcus granulosus para nitrobenzyl esterase 0.0036 0.0494 0.0596
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0017 0.0041 0.0041
Brugia malayi Carboxylesterase family protein 0.0036 0.0494 0.0966
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.0036 0.0494 1
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0017 0.0041 0.0041
Echinococcus multilocularis carboxylesterase 5A 0.0211 0.4771 0.5762
Schistosoma mansoni polycystin 1-related 0.002 0.0104 0.0104
Echinococcus granulosus cathepsin d lysosomal aspartyl protease 0.0017 0.0041 0.0049
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0017 0.0041 0.0041
Trichomonas vaginalis carboxylesterase domain containing protein, putative 0.0036 0.0494 1
Schistosoma mansoni lipoxygenase 0.0055 0.0969 0.0969
Onchocerca volvulus 0.002 0.0104 0.131
Loa Loa (eye worm) doublecortin family protein 0.002 0.0104 0.0204
Echinococcus granulosus BC026374 protein S09 family 0.0036 0.0494 0.0596
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0017 0.0041 0.0041
Onchocerca volvulus 0.0036 0.0494 0.6207
Schistosoma mansoni hypothetical protein 0.0356 0.828 0.828
Brugia malayi hypothetical protein 0.002 0.0104 0.0204
Schistosoma mansoni cellular tumor antigen P53 0.0048 0.0795 0.0795
Loa Loa (eye worm) hypothetical protein 0.0036 0.0494 0.0966
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0082 0.0914
Echinococcus granulosus lipoxygenase domain containing protein 0.002 0.0104 0.0126
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0019 0.0082 0.5
Brugia malayi aspartic protease BmAsp-1, identical 0.0017 0.0041 0.0079
Schistosoma mansoni rab6-interacting 0.002 0.0104 0.0104
Schistosoma mansoni cell polarity protein 0.0026 0.0248 0.0248
Echinococcus multilocularis Polycystic kidney disease protein 0.002 0.0104 0.0126
Onchocerca volvulus 0.0017 0.0041 0.051
Onchocerca volvulus 0.0036 0.0494 0.6207
Onchocerca volvulus 0.0036 0.0494 0.6207

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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