Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | C2-HC type zinc finger protein C.e-MyT1 | 0.0027 | 0.0123 | 0.0556 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0027 | 0.0124 | 0.0558 |
Schistosoma mansoni | tar DNA-binding protein | 0.0058 | 0.0333 | 0.3164 |
Brugia malayi | jmjC domain containing protein | 0.0048 | 0.0263 | 0.1185 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-40 | 0.0014 | 0.0036 | 0.0164 |
Loa Loa (eye worm) | hypothetical protein | 0.0048 | 0.0266 | 0.12 |
Loa Loa (eye worm) | hypothetical protein | 0.0014 | 0.0036 | 0.0164 |
Brugia malayi | Pre-SET motif family protein | 0.0336 | 0.2219 | 1 |
Schistosoma mansoni | ap endonuclease | 0.0038 | 0.0199 | 0.1728 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0014 | 0.0036 | 0.0164 |
Toxoplasma gondii | hypothetical protein | 0.1485 | 1 | 1 |
Toxoplasma gondii | histone lysine methyltransferase SET/SUV39 | 0.0048 | 0.0266 | 0.0229 |
Echinococcus granulosus | histone acetyltransferase MYST2 | 0.0027 | 0.0123 | 0.1468 |
Echinococcus multilocularis | endonuclease exonuclease phosphatase | 0.0102 | 0.0629 | 1 |
Echinococcus multilocularis | Transcription factor, JmjC domain containing protein | 0.0048 | 0.0263 | 0.3825 |
Echinococcus granulosus | endonuclease exonuclease phosphatase | 0.0102 | 0.0629 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0014 | 0.0036 | 0.0164 |
Onchocerca volvulus | Alhambra homolog | 0.0015 | 0.0038 | 0.0007 |
Echinococcus granulosus | PHD finger protein rhinoceros | 0.0015 | 0.0038 | 0.0029 |
Mycobacterium leprae | PROBABLE POLYPEPTIDE DEFORMYLASE DEF (PDF) (FORMYLMETHIONINE DEFORMYLASE) | 0.1485 | 1 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-14 | 0.0014 | 0.0036 | 0.0164 |
Loa Loa (eye worm) | nuclear Hormone Receptor family member | 0.0014 | 0.0036 | 0.0164 |
Schistosoma mansoni | lamin | 0.0017 | 0.0053 | 0.0173 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0027 | 0.0124 | 0.0931 |
Brugia malayi | exodeoxyribonuclease III family protein | 0.0038 | 0.0199 | 0.0895 |
Loa Loa (eye worm) | jmjC domain-containing protein | 0.003 | 0.0143 | 0.0646 |
Echinococcus granulosus | DNA apurinic or apyrimidinic site lyase | 0.0038 | 0.0199 | 0.2736 |
Loa Loa (eye worm) | MBCTL1 | 0.0027 | 0.0123 | 0.0556 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0027 | 0.0124 | 0.0931 |
Schistosoma mansoni | intermediate filament proteins | 0.0017 | 0.0053 | 0.0173 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-49 | 0.0014 | 0.0036 | 0.0164 |
Brugia malayi | PHD-finger family protein | 0.0015 | 0.0038 | 0.0172 |
Schistosoma mansoni | jumonji/arid domain-containing protein | 0.0018 | 0.0059 | 0.024 |
Brugia malayi | Intermediate filament tail domain containing protein | 0.0017 | 0.0053 | 0.0237 |
Brugia malayi | TAR-binding protein | 0.0058 | 0.0333 | 0.1502 |
Loa Loa (eye worm) | hypothetical protein | 0.0017 | 0.0053 | 0.0237 |
Loa Loa (eye worm) | TAR-binding protein | 0.0058 | 0.0333 | 0.1502 |
Loa Loa (eye worm) | intermediate filament protein | 0.0017 | 0.0053 | 0.0237 |
Brugia malayi | mbt repeat family protein | 0.0024 | 0.0101 | 0.0455 |
Schistosoma mansoni | histone-lysine n-methyltransferase suv9 | 0.0048 | 0.0266 | 0.245 |
Echinococcus multilocularis | jumonji domain containing protein | 0.002 | 0.0077 | 0.0682 |
Echinococcus multilocularis | suppression of tumorigenicity 18 protein | 0.0027 | 0.0123 | 0.1468 |
Plasmodium vivax | SET domain protein, putative | 0.0048 | 0.0266 | 0.0229 |
Echinococcus multilocularis | histone lysine methyltransferase setb histone lysine methyltransferase eggless | 0.0048 | 0.0266 | 0.388 |
Mycobacterium ulcerans | peptide deformylase | 0.1485 | 1 | 1 |
Loa Loa (eye worm) | mbt repeat family protein | 0.0024 | 0.0101 | 0.0455 |
Schistosoma mansoni | jumonji/arid domain-containing protein | 0.0018 | 0.0059 | 0.024 |
Toxoplasma gondii | exonuclease III APE | 0.0038 | 0.0199 | 0.0161 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-14 | 0.0014 | 0.0036 | 0.0164 |
Schistosoma mansoni | jumonji domain containing protein | 0.0038 | 0.0196 | 0.1706 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-41 | 0.0014 | 0.0036 | 0.0164 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0058 | 0.0333 | 0.1502 |
Onchocerca volvulus | Polycomb protein Sfmbt homolog | 0.0024 | 0.0101 | 0.0259 |
Mycobacterium tuberculosis | Probable polypeptide deformylase Def (PDF) (formylmethionine deformylase) | 0.1485 | 1 | 1 |
Schistosoma mansoni | sex comb on midleg homolog | 0.0024 | 0.0101 | 0.0688 |
Loa Loa (eye worm) | RNA binding protein | 0.0058 | 0.0333 | 0.1502 |
Echinococcus granulosus | tar DNA binding protein | 0.0058 | 0.0333 | 0.5011 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0048 | 0.0266 | 0.245 |
Wolbachia endosymbiont of Brugia malayi | peptide deformylase | 0.1485 | 1 | 1 |
Plasmodium falciparum | peptide deformylase | 0.1485 | 1 | 1 |
Schistosoma mansoni | ap endonuclease | 0.0038 | 0.0199 | 0.1728 |
Treponema pallidum | polypeptide deformylase (def) | 0.1485 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0014 | 0.0036 | 0.0164 |
Loa Loa (eye worm) | hypothetical protein | 0.0014 | 0.0036 | 0.0164 |
Echinococcus granulosus | lamin dm0 | 0.0017 | 0.0053 | 0.0273 |
Schistosoma mansoni | hypothetical protein | 0.0015 | 0.0038 | 0.0018 |
Echinococcus granulosus | lamin | 0.0017 | 0.0053 | 0.0273 |
Trypanosoma cruzi | polypeptide deformylase-like protein, putative | 0.0566 | 0.3778 | 1 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0018 | 0.0061 | 0.0265 |
Loa Loa (eye worm) | hypothetical protein | 0.0014 | 0.0036 | 0.0164 |
Trichomonas vaginalis | set domain proteins, putative | 0.0383 | 0.2534 | 1 |
Echinococcus granulosus | 5'partial|histone lysine N methyltransferase SETDB2 | 0.0046 | 0.0254 | 0.3677 |
Loa Loa (eye worm) | hypothetical protein | 0.0014 | 0.0036 | 0.0164 |
Loa Loa (eye worm) | hypothetical protein | 0.0014 | 0.0036 | 0.0164 |
Schistosoma mansoni | tar DNA-binding protein | 0.0058 | 0.0333 | 0.3164 |
Echinococcus granulosus | SAM and MBT domain containing protein | 0.0024 | 0.0101 | 0.109 |
Schistosoma mansoni | lamin | 0.0017 | 0.0053 | 0.0173 |
Loa Loa (eye worm) | steroid hormone receptor | 0.0014 | 0.0036 | 0.0164 |
Loa Loa (eye worm) | hypothetical protein | 0.0016 | 0.0051 | 0.0228 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-31 | 0.0014 | 0.0036 | 0.0164 |
Echinococcus multilocularis | polycomb protein SCMH1 | 0.0024 | 0.0101 | 0.109 |
Schistosoma mansoni | hypothetical protein | 0.0153 | 0.0975 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0027 | 0.0124 | 0.0931 |
Echinococcus granulosus | Transcription factor JmjC domain containing protein | 0.0048 | 0.0263 | 0.3825 |
Loa Loa (eye worm) | PHD-finger family protein | 0.0015 | 0.0038 | 0.0172 |
Loa Loa (eye worm) | hypothetical protein | 0.0015 | 0.0038 | 0.0172 |
Trypanosoma cruzi | Peptide deformylase 2, putative | 0.0566 | 0.3778 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0058 | 0.0333 | 0.3164 |
Loa Loa (eye worm) | pre-SET domain-containing protein family protein | 0.0336 | 0.2219 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-1 | 0.0014 | 0.0036 | 0.0164 |
Echinococcus multilocularis | lamin | 0.0017 | 0.0053 | 0.0273 |
Brugia malayi | Bromodomain containing protein | 0.0015 | 0.0038 | 0.0172 |
Trypanosoma cruzi | Peptide deformylase 2, putative | 0.0566 | 0.3778 | 1 |
Brugia malayi | hypothetical protein | 0.0018 | 0.0061 | 0.0276 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-1 | 0.0014 | 0.0036 | 0.0164 |
Brugia malayi | intermediate filament protein | 0.0017 | 0.0053 | 0.0237 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0014 | 0.0036 | 0.0164 |
Echinococcus granulosus | intermediate filament protein | 0.0017 | 0.0053 | 0.0273 |
Loa Loa (eye worm) | hypothetical protein | 0.0014 | 0.0036 | 0.0164 |
Echinococcus multilocularis | histone lysine N methyltransferase SETMAR | 0.0048 | 0.0266 | 0.388 |
Loa Loa (eye worm) | intermediate filament tail domain-containing protein | 0.0017 | 0.0053 | 0.0237 |
Echinococcus multilocularis | SAM and MBT domain containing protein | 0.0024 | 0.0101 | 0.109 |
Entamoeba histolytica | exodeoxyribonuclease III, putative | 0.0038 | 0.0199 | 1 |
Brugia malayi | nuclear hormone receptor | 0.0014 | 0.0036 | 0.0164 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0014 | 0.0036 | 0.0164 |
Schistosoma mansoni | myelin transcription factor 1 myt1 | 0.0027 | 0.0123 | 0.0927 |
Schistosoma mansoni | tar DNA-binding protein | 0.0058 | 0.0333 | 0.3164 |
Echinococcus multilocularis | lamin dm0 | 0.0017 | 0.0053 | 0.0273 |
Loa Loa (eye worm) | hypothetical protein | 0.0024 | 0.0101 | 0.0455 |
Echinococcus multilocularis | peregrin | 0.0015 | 0.0038 | 0.0029 |
Trypanosoma cruzi | polypeptide deformylase-like protein, putative | 0.0566 | 0.3778 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0014 | 0.0036 | 0.0164 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0048 | 0.0266 | 0.245 |
Onchocerca volvulus | 0.0024 | 0.0101 | 0.0259 | |
Brugia malayi | RNA binding protein | 0.0058 | 0.0333 | 0.1502 |
Onchocerca volvulus | 0.0017 | 0.0053 | 0.0065 | |
Leishmania major | polypeptide deformylase-like protein, putative | 0.0566 | 0.3778 | 1 |
Echinococcus granulosus | jumonji domain containing protein | 0.002 | 0.0077 | 0.0682 |
Schistosoma mansoni | tar DNA-binding protein | 0.0058 | 0.0333 | 0.3164 |
Echinococcus granulosus | peregrin | 0.0015 | 0.0038 | 0.0029 |
Loa Loa (eye worm) | jmjC domain-containing protein | 0.0018 | 0.0059 | 0.0266 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0027 | 0.0124 | 0.0558 |
Echinococcus granulosus | polycomb protein SCMH1 | 0.0024 | 0.0101 | 0.109 |
Schistosoma mansoni | scm-relatedprotein containing 4 mbt domains (sfmbt) | 0.0024 | 0.0101 | 0.0688 |
Trypanosoma brucei | Peptide deformylase 2 | 0.0566 | 0.3778 | 1 |
Plasmodium vivax | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.0038 | 0.0199 | 0.0161 |
Onchocerca volvulus | 0.0017 | 0.0053 | 0.0065 | |
Brugia malayi | Nuclear hormone receptor family member nhr-41 | 0.0014 | 0.0036 | 0.0164 |
Loa Loa (eye worm) | hypothetical protein | 0.0027 | 0.0123 | 0.0556 |
Brugia malayi | nuclear receptor NHR-88 | 0.0014 | 0.0036 | 0.0164 |
Plasmodium falciparum | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.0038 | 0.0199 | 0.0161 |
Brugia malayi | mbt repeat family protein | 0.0024 | 0.0101 | 0.0455 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0014 | 0.0036 | 0.0164 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0048 | 0.0266 | 0.245 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0027 | 0.0124 | 0.1474 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0014 | 0.0036 | 0.0164 |
Echinococcus multilocularis | PHD finger protein rhinoceros | 0.0015 | 0.0038 | 0.0029 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0027 | 0.0124 | 0.1474 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0014 | 0.0036 | 0.0164 |
Brugia malayi | jmjC domain containing protein | 0.0018 | 0.0059 | 0.0266 |
Brugia malayi | Nuclear hormone receptor family member nhr-49 | 0.0014 | 0.0036 | 0.0164 |
Echinococcus multilocularis | DNA (apurinic or apyrimidinic site) lyase | 0.0038 | 0.0199 | 0.2736 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0027 | 0.0124 | 0.1474 |
Echinococcus multilocularis | musashi | 0.0017 | 0.0053 | 0.0273 |
Brugia malayi | Pre-SET motif family protein | 0.0048 | 0.0266 | 0.12 |
Trypanosoma brucei | Polypeptide deformylase 1 | 0.0566 | 0.3778 | 1 |
Schistosoma mansoni | bromodomain-containing nuclear protein 1 brd1 | 0.0015 | 0.0038 | 0.0018 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0018 | 0.0061 | 0.0419 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0058 | 0.0333 | 0.1502 |
Brugia malayi | Nuclear hormone receptor family member nhr-31 | 0.0014 | 0.0036 | 0.0164 |
Onchocerca volvulus | 0.0383 | 0.2534 | 1 | |
Echinococcus granulosus | lysine specific demethylase 5A | 0.0018 | 0.0059 | 0.038 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0018 | 0.0061 | 0.0419 |
Plasmodium vivax | peptide deformylase, putative | 0.1485 | 1 | 1 |
Giardia lamblia | Endonuclease/Exonuclease/phosphatase | 0.0038 | 0.0199 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-40 | 0.0014 | 0.0036 | 0.0164 |
Echinococcus multilocularis | tar DNA binding protein | 0.0058 | 0.0333 | 0.5011 |
Brugia malayi | Nuclear hormone receptor family member nhr-3 | 0.0014 | 0.0036 | 0.0164 |
Loa Loa (eye worm) | hypothetical protein | 0.0025 | 0.0109 | 0.049 |
Brugia malayi | steroid hormone receptor | 0.0014 | 0.0036 | 0.0164 |
Echinococcus multilocularis | lysine specific demethylase 5A | 0.0018 | 0.0059 | 0.038 |
Loa Loa (eye worm) | exodeoxyribonuclease III family protein | 0.0038 | 0.0199 | 0.0895 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0027 | 0.0124 | 0.1474 |
Echinococcus granulosus | histone lysine methyltransferase setb | 0.0048 | 0.0266 | 0.388 |
Echinococcus multilocularis | histone acetyltransferase MYST2 | 0.0027 | 0.0123 | 0.1468 |
Onchocerca volvulus | 0.0048 | 0.0266 | 0.092 | |
Brugia malayi | ecdysteroid receptor | 0.0014 | 0.0036 | 0.0164 |
Echinococcus granulosus | suppression of tumorigenicity 18 protein | 0.0027 | 0.0123 | 0.1468 |
Schistosoma mansoni | hypothetical protein | 0.0018 | 0.0061 | 0.0265 |
Schistosoma mansoni | sex comb on midleg homolog | 0.0024 | 0.0101 | 0.0688 |
Brugia malayi | photoreceptor-specific nuclear receptor | 0.0014 | 0.0036 | 0.0164 |
Brugia malayi | Steroid receptor seven-up type 2 | 0.0014 | 0.0036 | 0.0164 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.