TDR Targets

Basic information

Technical information

TDR Targets ID: 862652
Name: N-[3-(4-methylpiperazin-1-yl)propyl]-4-(2-oxo pyrido[2,3-b][1,4]thiazin-1-yl)butanamide
MW: 391.531 | Formula: C19H29N5O2S
H donors: 1 H acceptors: 3 LogP: 0.67 Rotable bonds: 9
Rule of 5 violations (Lipinski): 1
SMILES: CN1CCN(CC1)CCCNC(=O)CCCN1C(=O)CSc2c1cccn2
InChi: 1S/C19H29N5O2S/c1-22-11-13-23(14-12-22)9-4-8-20-17(25)6-3-10-24-16-5-2-7-21-19(16)27-15-18(24)26/h2,5,7H,3-4,6,8-15H2,1H3,(H,20,25)
InChiKey: LRCNWYATWAUIRX-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

N-[3-(4-methyl-1-piperazinyl)propyl]-4-(2-oxo-1-pyrido[2,3-b][1,4]thiazinyl)butanamide
4-(2-ketopyrido[2,3-b][1,4]thiazin-1-yl)-N-[3-(4-methylpiperazin-1-yl)propyl]butyramide

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Loa Loa (eye worm)	TK/INSR protein kinase	0.0059	0.1697	0.1665
Schistosoma mansoni	protein kinase	0.007	0.2073	0.2075
Schistosoma mansoni	serine/threonine protein kinase	0.0074	0.2235	0.224
Echinococcus multilocularis	tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase	0.0029	0.0619	0.06
Trypanosoma brucei	kinetoplastid kinetochore protein 19	0.0074	0.2235	0.4228
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0198	0.0161
Trypanosoma cruzi	casein kinase II, putative	0.0157	0.5173	1
Brugia malayi	Protein kinase domain containing protein	0.0016	0.0139	0.0102
Trichomonas vaginalis	CMGC family protein kinase	0.0157	0.5173	1
Echinococcus multilocularis	proto oncogene serine:threonine protein kinase	0.0185	0.6186	0.625
Trichomonas vaginalis	AGC family protein kinase	0.002	0.031	0.0599
Schistosoma mansoni	tyrosine kinase	0.0096	0.2994	0.3011
Echinococcus granulosus	roundabout 2	0.0021	0.0317	0.0293
Schistosoma mansoni	defective proboscis extension response (dpr)-related	0.0013	0.0047	0.0019
Trypanosoma cruzi	aurora B kinase, putative	0.007	0.2073	0.3914
Brugia malayi	hypothetical protein	0.0013	0.0047	0.0009
Echinococcus granulosus	neuroglian	0.0016	0.0166	0.014
Echinococcus multilocularis	mitogen activated protein kinase kinase kinase	0.011	0.3509	0.3533
Loa Loa (eye worm)	AUR protein kinase	0.007	0.2073	0.2043
Trypanosoma brucei	kinetoplastid kinetochore protein 10	0.0074	0.2235	0.4228
Brugia malayi	Protein kinase domain containing protein	0.0018	0.0228	0.0191
Loa Loa (eye worm)	AGC/AKT protein kinase	0.002	0.031	0.0273
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0317	0.028
Loa Loa (eye worm)	TK/FER protein kinase	0.0018	0.0228	0.0191
Trypanosoma cruzi	STE/STE11 serine/threonine-protein kinase, putative	0.0014	0.0083	0.0007
Trichomonas vaginalis	AGC family protein kinase	0.002	0.031	0.0599
Onchocerca volvulus		0.0018	0.0228	0.0221
Echinococcus multilocularis	guanine nucleotide exchange factor VAV2	0.002	0.0285	0.0261
Onchocerca volvulus		0.0155	0.5095	0.7423
Loa Loa (eye worm)	TK/FER protein kinase	0.0018	0.0228	0.0191
Loa Loa (eye worm)	hypothetical protein	0.0013	0.0047	0.0009
Schistosoma mansoni	protein kinase	0.0157	0.5173	0.5222
Echinococcus granulosus	Ribosomal protein S6 kinase beta 2	0.0019	0.0255	0.0231
Echinococcus multilocularis	Immunoglobulin	0.0013	0.0047	0.0019
Echinococcus multilocularis	tyrosine protein kinase Srms	0.0018	0.0228	0.0203
Schistosoma mansoni	hypothetical protein	0.0019	0.0271	0.0247
Entamoeba histolytica	protein kinase, putative	0.0121	0.3889	0.7505
Plasmodium vivax	casein kinase 2, alpha subunit, putative	0.0157	0.5173	1
Echinococcus granulosus	Serine/threonine-protein kinase Genghis Khan	0.0016	0.0139	0.0113
Schistosoma mansoni	vav2	0.0021	0.034	0.0316
Echinococcus granulosus	protein tyrosine kinase	0.0289	0.988	1
Schistosoma mansoni	tyrosine kinase	0.0018	0.0228	0.0203
Echinococcus multilocularis	tyrosine protein kinase Src42A	0.0014	0.0089	0.0062
Brugia malayi	Variant SH3 domain containing protein	0.0022	0.0374	0.0338
Plasmodium vivax	serine/threonine-specific protein kinase, putative	0.0121	0.3889	0.586
Plasmodium falciparum	protein kinase, putative	0.0121	0.3889	0.7478
Entamoeba histolytica	protein kinase, putative	0.0019	0.0255	0.0442
Loa Loa (eye worm)	hypothetical protein	0.0013	0.0047	0.0009
Echinococcus multilocularis	aurora kinase A	0.007	0.2073	0.2075
Echinococcus multilocularis	tyrosine protein kinase Btk29A	0.0178	0.5918	0.5978
Trichomonas vaginalis	AGC family protein kinase	0.007	0.2073	0.4007
Leishmania major	protein kinase, putative	0.007	0.2073	0.3914
Trichomonas vaginalis	CMGC family protein kinase	0.0157	0.5173	1
Echinococcus granulosus	Ankyrin	0.0019	0.0271	0.0247
Loa Loa (eye worm)	CAMK/DAPK/DAPK protein kinase	0.0036	0.085	0.0815
Loa Loa (eye worm)	CAMK/PIM protein kinase	0.0185	0.6186	0.6171
Echinococcus granulosus	tyrosine protein kinase ABL1	0.0018	0.0228	0.0203
Trypanosoma brucei	aurora B kinase	0.007	0.2073	0.391
Echinococcus granulosus	hypothetical protein	0.0067	0.1979	0.1981
Loa Loa (eye worm)	hypothetical protein	0.0048	0.1284	0.125
Echinococcus granulosus	tyrosine protein kinase Src42A	0.0014	0.0089	0.0062
Schistosoma mansoni	serine/threonine protein kinase	0.0016	0.0139	0.0113
Trichomonas vaginalis	STE family protein kinase	0.0121	0.3889	0.7519
Echinococcus granulosus	tyrosine protein kinase shark	0.0018	0.0228	0.0203
Schistosoma mansoni	tyrosine kinase	0.0029	0.0619	0.06
Onchocerca volvulus		0.0018	0.0228	0.0221
Schistosoma mansoni	tyrosine kinase	0.0089	0.2749	0.2762
Trichomonas vaginalis	AGC family protein kinase	0.0019	0.0255	0.0494
Brugia malayi	Hr1 repeat family protein	0.0019	0.0255	0.0218
Brugia malayi	Protein kinase domain containing protein	0.0018	0.0228	0.0191
Echinococcus multilocularis	protein tyrosine kinase	0.0289	0.988	1
Schistosoma mansoni	protein kinase	0.0014	0.0083	0.0055
Loa Loa (eye worm)	hypothetical protein	0.0155	0.5095	0.5077
Schistosoma mansoni	nck2/grb4	0.0022	0.0374	0.0352
Onchocerca volvulus	Netrin receptor homolog	0.0023	0.039	0.046
Leishmania major	protein kinase, putative	0.0074	0.2235	0.4232
Plasmodium falciparum	serine/threonine protein kinase, putative	0.007	0.2073	0.391
Schistosoma mansoni	chimerin-related rho-gtpase-activating protein	0.002	0.0285	0.0261
Loa Loa (eye worm)	TK/FER protein kinase	0.0018	0.0228	0.0191
Onchocerca volvulus	Tyrosine kinase homolog	0.0203	0.6837	1
Entamoeba histolytica	protein kinase domain containing protein	0.0014	0.0083	0.0106
Onchocerca volvulus	Serine\/threonine protein kinase homolog	0.0185	0.6186	0.9036
Echinococcus multilocularis	ribosomal protein S6 kinase alpha 3	0.0019	0.0255	0.0231
Echinococcus multilocularis	protein kinase c iota type	0.0027	0.0557	0.0537
Echinococcus multilocularis	tyrosine protein kinase shark	0.0018	0.0228	0.0203
Brugia malayi	Variant SH3 domain containing protein	0.0014	0.0079	0.0041
Brugia malayi	Variant SH3 domain containing protein	0.002	0.0285	0.0248
Schistosoma mansoni	serine/threonine protein kinase	0.0027	0.0557	0.0537
Brugia malayi	Protein kinase domain containing protein	0.0018	0.0228	0.0191
Brugia malayi	Variant SH3 domain containing protein	0.0022	0.0374	0.0338
Echinococcus granulosus	protein kinase c iota type	0.0027	0.0557	0.0537
Entamoeba histolytica	serine/threonine- protein kinase 6 , putative	0.007	0.2073	0.3974
Brugia malayi	Protein kinase domain containing protein	0.0185	0.6186	0.6171
Echinococcus granulosus	tyrosine protein kinase Btk29A	0.0178	0.5918	0.5978
Toxoplasma gondii	cell-cycle-associated protein kinase CLK, putative	0.0074	0.2235	0.4228
Schistosoma mansoni	serine/threonine protein kinase	0.007	0.2073	0.2075
Trypanosoma cruzi	kinetoplastid kinetochore protein 19, putative	0.0074	0.2235	0.4232
Schistosoma mansoni	atypical protein kinase C	0.0027	0.0557	0.0537
Echinococcus multilocularis	netrin receptor unc 5	0.0024	0.0423	0.0401
Schistosoma mansoni	growth factor receptor-bound protein	0.0025	0.048	0.0459
Echinococcus multilocularis		0.0067	0.1979	0.1981
Onchocerca volvulus		0.0018	0.0228	0.0221
Echinococcus granulosus	growth factor receptor bound protein 2	0.0025	0.048	0.0459
Loa Loa (eye worm)	TK/FER protein kinase	0.0018	0.0228	0.0191
Loa Loa (eye worm)	RhoGAP domain-containing protein	0.002	0.0285	0.0248
Plasmodium vivax	unspecified product	0.0157	0.5173	1
Onchocerca volvulus		0.0018	0.0228	0.0221
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0273	0.0236
Schistosoma mansoni	serine/threonine protein kinase	0.0036	0.085	0.0834
Schistosoma mansoni	vesicular amine transporter	0.0013	0.0047	0.0019
Loa Loa (eye worm)	hypothetical protein	0.0013	0.0047	0.0009
Schistosoma mansoni	Neurotrimin precursor (hNT)	0.0013	0.0047	0.0019
Entamoeba histolytica	serine/threonine protein kinase 6, putative	0.007	0.2073	0.3974
Brugia malayi	Furin-like cysteine rich region family protein	0.0173	0.5751	0.5735
Trichomonas vaginalis	CMGC family protein kinase	0.0157	0.5173	1
Brugia malayi	Protein kinase c protein 2	0.0016	0.0139	0.0102
Echinococcus multilocularis	ribosomal protein s6 kinase beta 1	0.0019	0.0255	0.0231
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0029	0.0619	0.06
Echinococcus multilocularis	protein kinase c epsilon type	0.0027	0.0557	0.0537
Schistosoma mansoni	tyrosine kinase	0.0014	0.0097	0.007
Echinococcus granulosus	protein kinase c epsilon type	0.0027	0.0557	0.0537
Trichomonas vaginalis	AGC family protein kinase	0.007	0.2073	0.4007
Echinococcus multilocularis	serine threonine protein kinase	0.0019	0.0255	0.0231
Plasmodium falciparum	casein kinase 2, alpha subunit	0.0157	0.5173	1
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0029	0.0619	0.06
Echinococcus multilocularis	epidermal growth factor receptor	0.0096	0.2994	0.3011
Loa Loa (eye worm)	AGC/RSK/RSK protein kinase	0.0019	0.0255	0.0218
Schistosoma mansoni	tyrosine kinase	0.0089	0.2749	0.2762
Loa Loa (eye worm)	AUR protein kinase	0.007	0.2073	0.2043
Loa Loa (eye worm)	TK/FER protein kinase	0.0018	0.0228	0.0191
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0029	0.0619	0.06
Brugia malayi	protein kinase C3,putative	0.0016	0.0139	0.0102
Echinococcus multilocularis	ankyrin repeat and death domain containing protein	0.0019	0.0271	0.0247
Echinococcus multilocularis	N chimaerin	0.002	0.0285	0.0261
Echinococcus multilocularis	serine:threonine protein kinase N2	0.0019	0.0255	0.0231
Entamoeba histolytica	protein kinase, putative	0.0019	0.0255	0.0442
Schistosoma mansoni	netrin receptor unc5	0.0024	0.0423	0.0401
Trichomonas vaginalis	AGC family protein kinase	0.002	0.031	0.0599
Schistosoma mansoni	tyrosine kinase	0.0173	0.5751	0.5809
Echinococcus granulosus	activin receptor type	0.0014	0.0083	0.0055
Echinococcus granulosus	mitogen-activated protein kinase kinase kinase 9	0.011	0.3509	0.3533
Schistosoma mansoni	serine/threonine protein kinase	0.0027	0.0557	0.0537
Schistosoma mansoni	tyrosine kinase	0.0059	0.1697	0.1694
Loa Loa (eye worm)	CAMK/MLCK protein kinase	0.0015	0.0108	0.007
Trichomonas vaginalis	AGC family protein kinase	0.002	0.031	0.0599
Echinococcus multilocularis	serine:threonine protein kinase N2	0.0019	0.0255	0.0231
Schistosoma mansoni	proto-oncogene tyrosine-protein kinase abl1	0.0022	0.0374	0.0352
Echinococcus granulosus	tyrosine protein kinase Blk	0.0018	0.0228	0.0203
Brugia malayi	Protein kinase domain containing protein	0.0019	0.0255	0.0218
Schistosoma mansoni	adapter molecule crk	0.0022	0.0374	0.0352
Echinococcus multilocularis	tyrosine protein kinase ABL1	0.0018	0.0228	0.0203
Entamoeba histolytica	serine/threonine- protein kinase 6, putative	0.007	0.2073	0.3974
Brugia malayi	Protein kinase domain containing protein	0.002	0.031	0.0273
Echinococcus multilocularis	serine:threonine protein kinase MRCK beta	0.0016	0.0139	0.0113
Plasmodium vivax	serine/threonine kinase-1, putative	0.0074	0.2235	0.0522
Onchocerca volvulus		0.0193	0.6474	0.9462
Trichomonas vaginalis	CMGC family protein kinase	0.0157	0.5173	1
Trichomonas vaginalis	AGC family protein kinase	0.0019	0.0255	0.0494
Echinococcus granulosus	protein kinase C gamma type	0.0019	0.0255	0.0231
Echinococcus granulosus	tyrosine kinase	0.0018	0.0228	0.0203
Brugia malayi	SH2 domain containing protein	0.0018	0.0228	0.0191
Loa Loa (eye worm)	CMGC/CK2 protein kinase	0.0157	0.5173	0.5155
Loa Loa (eye worm)	hypothetical protein	0.0036	0.085	0.0815
Echinococcus multilocularis	c src tyrosine kinase	0.0029	0.0619	0.06
Trichomonas vaginalis	AGC family protein kinase	0.002	0.031	0.0599
Loa Loa (eye worm)	TK/FAK protein kinase	0.0292	1	1
Leishmania major	casein kinase II, putative	0.0157	0.5173	1
Echinococcus granulosus	twitchin	0.0024	0.0421	0.0399
Echinococcus granulosus	insulin receptor	0.0059	0.1697	0.1694
Loa Loa (eye worm)	sex muscle abnormal protein 5	0.0022	0.0374	0.0338
Brugia malayi	Protein kinase domain containing protein	0.0055	0.1539	0.1507
Trypanosoma cruzi	kinetoplastid kinetochore protein 10, putative	0.0074	0.2235	0.4232
Echinococcus granulosus	dual specificity testis-specific protein kinase	0.0014	0.0083	0.0055
Trypanosoma brucei	Casein kinase II	0.0157	0.5173	1
Trypanosoma brucei	rac serine-threonine kinase, putative	0.002	0.031	0.0447
Brugia malayi	serine/threonine protein kinase 6	0.007	0.2073	0.2043
Loa Loa (eye worm)	TK/FER protein kinase	0.0018	0.0228	0.0191
Brugia malayi	p70 ribosomal S6 kinase beta	0.0019	0.0255	0.0218
Brugia malayi	Death domain containing protein	0.0019	0.0271	0.0234
Loa Loa (eye worm)	hypothetical protein	0.0173	0.5768	0.5752
Echinococcus multilocularis		0.0052	0.1426	0.1419
Entamoeba histolytica	protein kinase domain containing protein	0.007	0.2073	0.3974
Loa Loa (eye worm)	CAMK/DAPK/DAPK protein kinase	0.0036	0.085	0.0815
Brugia malayi	Fibronectin type III domain containing protein	0.0013	0.0047	0.0009
Echinococcus granulosus	guanine nucleotide exchange factor VAV2	0.002	0.0285	0.0261
Echinococcus granulosus	ankyrin repeat and death domain containing protein	0.0019	0.0271	0.0247
Loa Loa (eye worm)	hypothetical protein	0.0013	0.0047	0.0009
Echinococcus multilocularis	serine:threonine protein kinase 38	0.0019	0.0255	0.0231
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0029	0.0619	0.06
Echinococcus granulosus	NCK adaptor protein	0.0022	0.0374	0.0352
Loa Loa (eye worm)	TK/FER protein kinase	0.0018	0.0228	0.0191
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0594	0.0559
Echinococcus multilocularis	intersectin 2	0.0014	0.0079	0.0052
Entamoeba histolytica	protein kinase, putative	0.0018	0.0239	0.0409
Echinococcus granulosus	c src tyrosine kinase	0.0029	0.0619	0.06
Trichomonas vaginalis	STE family protein kinase	0.0121	0.3889	0.7519
Schistosoma mansoni	serine/threonine protein kinase	0.0118	0.3794	0.3822
Entamoeba histolytica	protein kinase , putative	0.007	0.2073	0.3974
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0228	0.0191
Brugia malayi	Sex muscle abnormal protein 5	0.0022	0.0374	0.0338
Entamoeba histolytica	protein kinase, putative	0.007	0.2073	0.3974
Schistosoma mansoni	nephrin	0.0016	0.0166	0.014
Schistosoma mansoni	proto-oncogene tyrosine-protein kinase src	0.0029	0.0619	0.06
Echinococcus multilocularis	insulin receptor	0.0059	0.1697	0.1694
Loa Loa (eye worm)	SRC-1	0.0029	0.0619	0.0583
Onchocerca volvulus		0.0018	0.0229	0.0221
Echinococcus multilocularis	Immunoglobulin	0.0013	0.0047	0.0019
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0596	0.056
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0594	0.0559
Brugia malayi	Casein kinase II, alpha chain	0.0157	0.5173	0.5155
Schistosoma mansoni	protein kinase	0.0014	0.0083	0.0055
Toxoplasma gondii	CMGC kinase, CK2 family	0.0157	0.5173	1
Loa Loa (eye worm)	hypothetical protein	0.0013	0.0047	0.0009
Brugia malayi	SRC-1	0.0029	0.0619	0.0583
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0029	0.0619	0.06
Loa Loa (eye worm)	AGC/PKN protein kinase	0.0019	0.0255	0.0218
Loa Loa (eye worm)	variant SH3 domain-containing protein	0.0022	0.0374	0.0338
Brugia malayi	serine/threonine kinase 12	0.007	0.2073	0.2043
Schistosoma mansoni	ankyrin 23/unc44	0.0019	0.0273	0.0249
Brugia malayi	Uncoordinated protein 44	0.0019	0.0273	0.0236
Echinococcus multilocularis	Protein kinase C, brain isozyme	0.0027	0.0557	0.0537
Echinococcus multilocularis	neuroglian	0.0016	0.0166	0.014
Schistosoma mansoni	serine/threonine protein kinase	0.0016	0.0139	0.0113
Trypanosoma cruzi	kinetoplastid kinetochore protein 10, putative	0.0074	0.2235	0.4232
Loa Loa (eye worm)	TK/KIN16 protein kinase	0.0217	0.7335	0.7324
Entamoeba histolytica	protein kinase, putative	0.002	0.031	0.0548
Schistosoma mansoni	cell adhesion molecule	0.0017	0.0198	0.0173
Echinococcus multilocularis	Ribosomal protein S6 kinase beta 2	0.0019	0.0255	0.0231
Loa Loa (eye worm)	TK/FER protein kinase	0.0018	0.0228	0.0191
Echinococcus granulosus	proto oncogene serine:threonine protein kinase	0.0185	0.6186	0.625
Echinococcus multilocularis	tyrosine protein kinase Abl	0.0029	0.0619	0.06
Onchocerca volvulus		0.0018	0.0228	0.0221
Echinococcus multilocularis	NCK adaptor protein	0.0025	0.048	0.0459
Echinococcus granulosus	netrin receptor unc 5	0.0024	0.0423	0.0401
Echinococcus multilocularis	tyrosine protein kinase Src42A	0.0029	0.0619	0.06
Loa Loa (eye worm)	AGC/RSK/MSK protein kinase	0.0019	0.0255	0.0218
Echinococcus granulosus	defective proboscis extension response	0.0013	0.0047	0.0019
Loa Loa (eye worm)	AGC/RSK/P70 protein kinase	0.0019	0.0255	0.0218
Echinococcus multilocularis	tyrosine protein kinase Fps85D	0.0018	0.0228	0.0203
Brugia malayi	Protein kinase domain containing protein	0.0059	0.1697	0.1665
Echinococcus granulosus	tyrosine kinase	0.0018	0.0228	0.0203
Schistosoma mansoni	serine/threonine kinase	0.0019	0.0255	0.0231
Trichomonas vaginalis	AGC family protein kinase	0.007	0.2073	0.4007
Echinococcus granulosus	tyrosine kinase\|tyrosine protein kinase Fyn	0.0018	0.0228	0.0203
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0024	0.0423	0.0386
Entamoeba histolytica	protein kinase, putative	0.007	0.2073	0.3974
Schistosoma mansoni	tyrosine kinase	0.0029	0.0619	0.06
Echinococcus granulosus	neurotracting:lsamp:neurotrimin:obcam	0.0017	0.0198	0.0173
Schistosoma mansoni	serine/threonine protein kinase	0.0019	0.0255	0.0231
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0374	0.0338
Echinococcus multilocularis	Ankyrin	0.0019	0.0273	0.0249
Echinococcus multilocularis	raf serine:threonine protein kinase	0.0015	0.0129	0.0103
Echinococcus granulosus	ribosomal protein s6 kinase beta 1	0.0019	0.0255	0.0231
Echinococcus granulosus	dual specificity protein kinase clk2	0.0074	0.2235	0.224
Echinococcus granulosus	Protein kinase C brain isozyme	0.0027	0.0557	0.0537
Schistosoma mansoni	serine/threonine protein kinase	0.0074	0.2235	0.224
Trypanosoma cruzi	STE/STE11 serine/threonine-protein kinase, putative	0.0014	0.0083	0.0007
Echinococcus multilocularis	dual specificity protein kinase clk2	0.0074	0.2235	0.224
Loa Loa (eye worm)	CAMK/PIM protein kinase	0.0185	0.6186	0.6171
Trichomonas vaginalis	CMGC family protein kinase	0.0157	0.5173	1
Loa Loa (eye worm)	AGC/PKC/IOTA protein kinase	0.0016	0.0139	0.0102
Echinococcus multilocularis	serine threonine protein kinase	0.0121	0.3889	0.3919
Schistosoma mansoni	retinoblastoma-binding protein 4 (rbbp4)	0.0019	0.0271	0.0247
Schistosoma mansoni	tyrosine kinase	0.0059	0.1697	0.1694
Echinococcus granulosus	ribosomal protein S6 kinase alpha 3	0.0019	0.0255	0.0231
Giardia lamblia	Kinase, CMGC CLK	0.0074	0.2235	0.0522
Echinococcus multilocularis	insulin growth factor 1 receptor beta	0.0059	0.1697	0.1694
Echinococcus granulosus	epidermal growth factor receptor	0.0173	0.5751	0.5809
Echinococcus multilocularis	tyrosine protein kinase Blk	0.0018	0.0228	0.0203
Trichomonas vaginalis	AGC family protein kinase	0.007	0.2073	0.4007
Trichomonas vaginalis	AGC family protein kinase	0.002	0.031	0.0599
Echinococcus multilocularis	casein kinase ii subunit alpha	0.0157	0.5173	0.5222
Loa Loa (eye worm)	AUR protein kinase	0.007	0.2073	0.2043
Trichomonas vaginalis	CMGC family protein kinase	0.0074	0.2235	0.432
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0079	0.0041
Echinococcus multilocularis	growth factor receptor bound protein 2	0.0022	0.0374	0.0352
Loa Loa (eye worm)	TK/ABL protein kinase	0.0018	0.0228	0.0191
Loa Loa (eye worm)	hypothetical protein	0.0067	0.1979	0.1949
Loa Loa (eye worm)	immunoglobulin I-set domain-containing protein	0.0019	0.0271	0.0234
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0018	0.0228	0.0203
Onchocerca volvulus		0.0018	0.0228	0.0221
Leishmania major	protein kinase, putative	0.0074	0.2235	0.4232
Brugia malayi	SH2 domain containing protein	0.0018	0.0228	0.0191
Entamoeba histolytica	protein kinase domain containing protein	0.0157	0.5173	1
Trypanosoma cruzi	kinetoplastid kinetochore protein 19, putative	0.0074	0.2235	0.4232
Brugia malayi	protein kinase C II.	0.0027	0.0557	0.0521
Loa Loa (eye worm)	AGC/NDR protein kinase	0.0019	0.0255	0.0218
Plasmodium falciparum	protein serine/threonine kinase-1	0.0074	0.2235	0.4228
Echinococcus multilocularis	tyrosine protein kinase Src64B	0.0029	0.0619	0.06
Brugia malayi	Protein kinase domain containing protein	0.0018	0.0228	0.0191
Loa Loa (eye worm)	hypothetical protein	0.0155	0.5095	0.5077
Toxoplasma gondii	aurora kinase	0.007	0.2073	0.391
Echinococcus granulosus	NDR protein kinase	0.0019	0.0255	0.0231
Loa Loa (eye worm)	TK/FER protein kinase	0.0018	0.0228	0.0191
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0029	0.0619	0.06
Trichomonas vaginalis	CMGC family protein kinase	0.0157	0.5173	1
Entamoeba histolytica	SH2-protein kinase domain containing protein	0.0018	0.0228	0.0389
Giardia lamblia	Kinase, CMGC CK2	0.0157	0.5173	1
Echinococcus granulosus	death domain containing protein	0.0019	0.0271	0.0247
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0013	0.0047	0.0009
Schistosoma mansoni	serine/threonine protein kinase	0.0121	0.3889	0.3919
Schistosoma mansoni	serine/threonine protein kinase	0.0019	0.0255	0.0231
Echinococcus granulosus	proto oncogene tyrosine protein kinase LCK	0.0029	0.0619	0.06
Loa Loa (eye worm)	hypothetical protein	0.0155	0.5095	0.5077
Toxoplasma gondii	AGC kinase	0.0019	0.0255	0.034
Schistosoma mansoni	growth factor receptor-bound protein	0.0022	0.0374	0.0352
Brugia malayi	RhoGAP domain containing protein	0.002	0.0285	0.0248
Echinococcus granulosus	epidermal growth factor receptor	0.0096	0.2994	0.3011
Brugia malayi	Phorbol esters/diacylglycerol binding domain	0.0016	0.0139	0.0102
Schistosoma mansoni	dynamin-associated protein	0.0014	0.0079	0.0052
Schistosoma mansoni	chimerin-related rho-gtpase-activating protein	0.002	0.0285	0.0261
Echinococcus granulosus	3'partial\|tyrosine protein kinase Fgr	0.0029	0.0619	0.06
Schistosoma mansoni	serine/threonine protein kinase	0.0019	0.0255	0.0231
Brugia malayi	Protein kinase domain containing protein	0.0074	0.2235	0.2205
Echinococcus granulosus	tyrosine protein kinase Src64B	0.0029	0.0619	0.06
Trichomonas vaginalis	AGC family protein kinase	0.002	0.031	0.0599
Loa Loa (eye worm)	hypothetical protein	0.0013	0.0047	0.0009
Schistosoma mansoni	tyrosine kinase	0.0029	0.0619	0.06
Loa Loa (eye worm)	CMGC/CLK protein kinase	0.0074	0.2235	0.2205
Brugia malayi	Protein kinase domain containing protein	0.0019	0.0255	0.0218
Trichomonas vaginalis	AGC family protein kinase	0.002	0.031	0.0599
Echinococcus multilocularis	tyrosine protein kinase Fgr	0.0029	0.0619	0.06
Brugia malayi	Serine/threonine-protein kinase Pim-3	0.0185	0.6186	0.6171
Trichomonas vaginalis	AGC family protein kinase	0.0019	0.0255	0.0494
Loa Loa (eye worm)	AGC/DMPK/GEK protein kinase	0.0019	0.0255	0.0218
Echinococcus granulosus	casein kinase ii subunit alpha	0.0157	0.5173	0.5222
Schistosoma mansoni	tyrosine kinase	0.0089	0.2749	0.2762
Echinococcus granulosus	tyrosine protein kinase Srms	0.0018	0.0228	0.0203
Loa Loa (eye worm)	hypothetical protein	0.0163	0.5397	0.538
Brugia malayi	Protein kinase domain containing protein	0.0018	0.0228	0.0191
Echinococcus granulosus	melanoma receptor tyrosine protein kinase	0.0096	0.2994	0.3011
Echinococcus granulosus	tyrosine protein kinase Src42A	0.0029	0.0619	0.06
Echinococcus multilocularis	proto oncogene tyrosine protein kinase LCK	0.0029	0.0619	0.06
Loa Loa (eye worm)	STE/STE20/YSK protein kinase	0.0121	0.3889	0.3866
Echinococcus multilocularis	dual specificity testis specific protein kinase	0.0014	0.0083	0.0055
Echinococcus granulosus	serine:threonine protein kinase N2	0.0019	0.0255	0.0231
Echinococcus multilocularis	basement membrane specific heparan sulfate	0.0013	0.0047	0.0019
Brugia malayi	protein-tyrosine kinase	0.0018	0.0228	0.0191
Echinococcus granulosus	serine:threonine protein kinase 12 B	0.007	0.2073	0.2075
Loa Loa (eye worm)	TK/EGFR protein kinase	0.0173	0.5751	0.5735
Echinococcus multilocularis	serine:threonine protein kinase 12 B	0.007	0.2073	0.2075
Echinococcus multilocularis	tyrosine kinase	0.0018	0.0228	0.0203
Echinococcus granulosus	aurora kinase A	0.007	0.2073	0.2075
Echinococcus multilocularis	epidermal growth factor receptor	0.0173	0.5751	0.5809
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0317	0.028
Schistosoma mansoni	tyrosine kinase	0.0096	0.2994	0.3011
Schistosoma mansoni	tyrosine kinase	0.0029	0.0619	0.06
Schistosoma mansoni	serine/threonine protein kinase	0.0027	0.0557	0.0537
Schistosoma mansoni	tyrosine kinase	0.017	0.5633	0.5689
Echinococcus multilocularis	roundabout 2	0.0021	0.0317	0.0293
Schistosoma mansoni	serine/threonine protein kinase	0.0019	0.0255	0.0231
Schistosoma mansoni	protein kinase	0.0014	0.0083	0.0055
Schistosoma mansoni	protein kinase C mu	0.0016	0.0139	0.0113
Echinococcus multilocularis	tyrosine protein kinase lyn tyrosine protein kinase blk	0.0029	0.0619	0.06
Loa Loa (eye worm)	AGC/PKC/ETA protein kinase	0.0027	0.0557	0.0521
Echinococcus granulosus	raf serine:threonine protein kinase	0.0015	0.0129	0.0103
Loa Loa (eye worm)	TK protein kinase	0.0018	0.0228	0.0191
Echinococcus granulosus	tyrosine protein kinase Fps85D	0.0018	0.0228	0.0203
Entamoeba histolytica	casein kinase, putative	0.0157	0.5173	1
Schistosoma mansoni	serine/threonine protein kinase	0.0015	0.0129	0.0103
Loa Loa (eye worm)	TK/FER protein kinase	0.0018	0.0228	0.0191
Schistosoma mansoni	serine/threonine protein kinase	0.0185	0.6186	0.625
Echinococcus granulosus	tyrosine protein kinase Lyn	0.0036	0.0874	0.0859
Echinococcus multilocularis	activin receptor type	0.0014	0.0083	0.0055
Loa Loa (eye worm)	CAMK/PKD protein kinase	0.0016	0.0139	0.0102
Echinococcus granulosus	insulin growth factor 1 receptor beta	0.0059	0.1697	0.1694
Echinococcus granulosus	Immunoglobulin	0.0013	0.0047	0.0019
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0217	0.7335	0.7324
Brugia malayi	hypothetical protein	0.0018	0.0228	0.0191
Leishmania major	protein kinase, putative	0.0014	0.0083	0.0007
Entamoeba histolytica	protein kinase, putative	0.002	0.031	0.0548
Schistosoma mansoni	tyrosine kinase	0.0289	0.988	1
Echinococcus granulosus	N chimaerin	0.002	0.0285	0.0261
Trichomonas vaginalis	CMGC family protein kinase	0.0157	0.5173	1
Brugia malayi	C1-like domain containing protein	0.0016	0.0139	0.0102
Brugia malayi	serine/threonine-protein kinase 6	0.007	0.2073	0.2043
Echinococcus granulosus	intersectin 2	0.0014	0.0079	0.0052
Echinococcus granulosus	serine threonine protein kinase	0.0121	0.3889	0.3919
Entamoeba histolytica	SH2-protein kinase domain containing protein	0.0018	0.0239	0.0409
Brugia malayi	Tyrosine-protein kinase abl-1	0.0029	0.0619	0.0583

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

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Bibliographic References

No literature references available for this target.

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Detailed information for compound 862652