TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 589.727 | Formula: C27H35N5O6S2
H donors: 1 H acceptors: 4 LogP: 1.32 Rotable bonds: 10
Rule of 5 violations (Lipinski): 2
SMILES: COc1ccc(cc1)N1CCN(CC1)CCNC(=O)CN1C(=O)CSc2c1cc(cc2)S(=O)(=O)N1CCOCC1
InChi: 1S/C27H35N5O6S2/c1-37-22-4-2-21(3-5-22)30-12-10-29(11-13-30)9-8-28-26(33)19-32-24-18-23(6-7-25(24)39-20-27(32)34)40(35,36)31-14-16-38-17-15-31/h2-7,18H,8-17,19-20H2,1H3,(H,28,33)
InChiKey: BLWJXGHYHILUNM-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Chlamydia trachomatis	dihydrofolate reductase	0.0177	0.1992	1
Entamoeba histolytica	NAD(FAD)-dependent dehydrogenase, putative	0.0071	0.0729	1
Loa Loa (eye worm)	RNA binding protein	0.0065	0.0662	0.0662
Schistosoma mansoni	nuclear receptor 2DBD-gamma	0.0018	0.0102	0.0102
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0102	0.0102
Echinococcus granulosus	NADP dependent isocitrate dehydrogenase	0.0016	0.0076	0.0272
Schistosoma mansoni	gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2	0.0146	0.1629	0.1629
Schistosoma mansoni	tyrosyl-DNA phosphodiesterase	0.0068	0.0694	0.0694
Echinococcus multilocularis	NADP dependent isocitrate dehydrogenase	0.0016	0.0076	0.0272
Brugia malayi	Nuclear hormone receptor family member nhr-3	0.0018	0.0102	0.0367
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0018	0.0102	0.0367
Onchocerca volvulus	Putative fad oxidoreductase	0.0071	0.0729	1
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0102	0.0102
Echinococcus granulosus	histone acetyltransferase KAT2B	0.0043	0.0398	0.1431
Trypanosoma cruzi	glycerol-3-phosphate dehydrogenase (FAD-dependent), putative	0.0071	0.0729	1
Echinococcus multilocularis	NADP dependent isocitrate dehydrogenase	0.0016	0.0076	0.0272
Onchocerca volvulus	Pyruvate dehydrogenase phosphatase regulatory subunit, mitochondrial homolog	0.0071	0.0729	1
Schistosoma mansoni	glycerol-3-phosphate dehydrogenase	0.0071	0.0729	0.0729
Mycobacterium ulcerans	glycerol-3-phosphate dehydrogenase	0.0071	0.0729	0.0652
Schistosoma mansoni	voltage-gated potassium channel	0.0042	0.0386	0.0386
Echinococcus granulosus	FTZ F1 alpha	0.0018	0.0102	0.0367
Leishmania major	dihydrofolate reductase-thymidylate synthase	0.0068	0.0691	0.9421
Trypanosoma brucei	tyrosyl-DNA Phosphodiesterase (Tdp1), putative	0.0068	0.0694	0.9475
Trypanosoma cruzi	dihydrofolate reductase-thymidylate synthase	0.0068	0.0691	0.9421
Plasmodium vivax	histone acetyltransferase GCN5, putative	0.0043	0.0398	0.4942
Brugia malayi	Steroid receptor seven-up type 2	0.0018	0.0102	0.0367
Echinococcus multilocularis	transcription factor Dp 1	0.0039	0.0354	0.1271
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0018	0.0102	0.0367
Schistosoma mansoni	dihydrofolate reductase	0.0177	0.1992	0.1992
Leishmania major	cytochrome p450-like protein	0.0017	0.0082	0.0104
Schistosoma mansoni	NADP-specific isocitrate dehydrogenase	0.0016	0.0076	0.0076
Loa Loa (eye worm)	dihydrofolate reductase	0.0177	0.1992	0.1992
Brugia malayi	isocitrate dehydrogenase	0.0016	0.0076	0.0272
Schistosoma mansoni	tar DNA-binding protein	0.0065	0.0662	0.0662
Schistosoma mansoni	ATP:guanidino kinase (Smc74)	0.0071	0.0729	0.0729
Trypanosoma cruzi	glycerol-3-phosphate dehydrogenase (FAD-dependent), putative	0.0071	0.0729	1
Schistosoma mansoni	voltage-gated potassium channel	0.0011	0.0018	0.0018
Echinococcus multilocularis	glycerol 3 phosphate dehydrogenase	0.0071	0.0729	0.2618
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0102	0.0102
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-41	0.0018	0.0102	0.0102
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0018	0.0018
Mycobacterium leprae	DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE)	0.0177	0.1992	0.1362
Loa Loa (eye worm)	CYP4Cod1	0.0017	0.0082	0.0082
Echinococcus granulosus	potassium voltage gated channel subfamily H	0.0011	0.0018	0.0066
Trypanosoma cruzi	FAD dependent oxidoreductase, putative	0.0071	0.0729	1
Echinococcus multilocularis	FAD dependent oxidoreductase domain containing protein	0.0071	0.0729	0.2618
Toxoplasma gondii	histone lysine acetyltransferase GCN5-A	0.0043	0.0398	0.4942
Echinococcus multilocularis	dihydrofolate reductase	0.0177	0.1992	0.7157
Onchocerca volvulus	Dimethylglycine dehydrogenase, mitochondrial homolog	0.0071	0.0729	1
Trypanosoma brucei	glycerol-3-phosphate dehydrogenase (FAD-dependent), putative	0.0071	0.0729	1
Schistosoma mansoni	hypothetical protein	0.0174	0.1962	0.1962
Echinococcus multilocularis	thyroid hormone receptor alpha	0.0018	0.0102	0.0367
Schistosoma mansoni	thyroid hormone receptor	0.0018	0.0102	0.0102
Toxoplasma gondii	histone lysine acetyltransferase GCN5-B	0.0043	0.0398	0.4942
Brugia malayi	Nuclear hormone receptor-like 1	0.0018	0.0102	0.0367
Schistosoma mansoni	d-amino acid oxidase	0.0849	1	1
Brugia malayi	pyruvate dehydrogenase phosphatase regulatory subunit precursor	0.0071	0.0729	0.2618
Loa Loa (eye worm)	acetyltransferase	0.0146	0.1629	0.1629
Echinococcus granulosus	ecdysone induced protein 78C	0.0018	0.0102	0.0367
Plasmodium falciparum	FAD-dependent glycerol-3-phosphate dehydrogenase, putative	0.0071	0.0729	1
Echinococcus multilocularis	FTZ F1 nuclear receptor protein	0.0018	0.0102	0.0367
Schistosoma mansoni	survival motor neuron protein	0.005	0.0476	0.0476
Mycobacterium ulcerans	D-amino acid oxidase Aao	0.0849	1	1
Brugia malayi	dihydrofolate reductase family protein	0.0177	0.1992	0.7157
Mycobacterium ulcerans	glycerol-3-phosphate dehydrogenase GlpD2	0.0071	0.0729	0.0652
Entamoeba histolytica	anaerobic glycerol-3-phosphate dehydrogenase subunit A, putative	0.0071	0.0729	1
Brugia malayi	dimethylglycine dehydrogenase, mitochondrial precursor, putative	0.0071	0.0729	0.2618
Echinococcus multilocularis	isocitrate dehydrogenase	0.0016	0.0076	0.0272
Schistosoma mansoni	RAR-like nuclear receptor	0.0018	0.0102	0.0102
Trypanosoma brucei	cytochrome P450, putative	0.0017	0.0082	0.0104
Echinococcus multilocularis	Nuclear hormone receptor family member nhr 41	0.0018	0.0102	0.0367
Echinococcus granulosus	potassium voltage gated channel subfamily H	0.0038	0.0344	0.1236
Trypanosoma cruzi	L-2-hydroxyglutarate dehydrogenase, mitochondrial, putative	0.0071	0.0729	1
Trypanosoma cruzi	tyrosyl-DNA Phosphodiesterase (Tdp1), putative	0.0068	0.0694	0.9475
Plasmodium falciparum	bifunctional dihydrofolate reductase-thymidylate synthase	0.0068	0.0691	0.9421
Plasmodium vivax	FAD-dependent glycerol-3-phosphate dehydrogenase, putative	0.0071	0.0729	1
Loa Loa (eye worm)	steroid hormone receptor	0.0018	0.0102	0.0102
Echinococcus granulosus	tar DNA binding protein	0.0065	0.0662	0.2378
Brugia malayi	Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog	0.0038	0.0344	0.1236
Trypanosoma brucei	L-2-hydroxyglutarate dehydrogenase, mitochondrial, putative	0.0071	0.0729	1
Schistosoma mansoni	tar DNA-binding protein	0.0065	0.0662	0.0662
Schistosoma mansoni	tar DNA-binding protein	0.0065	0.0662	0.0662
Loa Loa (eye worm)	hypothetical protein	0.0243	0.2783	0.2783
Schistosoma mansoni	tar DNA-binding protein	0.0065	0.0662	0.0662
Plasmodium vivax	bifunctional dihydrofolate reductase-thymidylate synthase, putative	0.0068	0.0691	0.9421
Trypanosoma brucei	electron transfer flavoprotein-ubiquinone oxidoreductase, putative	0.0071	0.0729	1
Brugia malayi	Cytochrome P450 family protein	0.0017	0.0082	0.0296
Schistosoma mansoni	FTZ-F1 nuclear receptor-like protein	0.0018	0.0102	0.0102
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0018	0.0102	0.0367
Mycobacterium ulcerans	D-amino acid oxidase Aao	0.0071	0.0729	0.0652
Schistosoma mansoni	coup transcription factor	0.0018	0.0102	0.0102
Echinococcus multilocularis	potassium voltage gated channel subfamily H	0.0038	0.0344	0.1236
Loa Loa (eye worm)	cytochrome P450 family protein	0.0017	0.0082	0.0082
Echinococcus multilocularis	tyrosyl DNA phosphodiesterase 1	0.0068	0.0694	0.2495
Schistosoma mansoni	NAD dehydrogenase	0.0071	0.0729	0.0729
Echinococcus multilocularis	gcn5proteinral control of amino acid synthesis	0.0146	0.1629	0.5854
Echinococcus multilocularis	ecdysone induced protein 78C	0.0018	0.0102	0.0367
Brugia malayi	Iron-sulfur cluster assembly accessory protein	0.005	0.0476	0.1712
Entamoeba histolytica	tyrosyl-DNA phosphodiesterase, putative	0.0068	0.0694	0.9082
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0102	0.0102
Echinococcus granulosus	retinoic acid receptor rxr beta a	0.0018	0.0102	0.0367
Toxoplasma gondii	FAD-dependent glycerol-3-phosphate dehydrogenase	0.0071	0.0729	1
Loa Loa (eye worm)	isocitrate dehydrogenase	0.0016	0.0076	0.0076
Brugia malayi	TAR-binding protein	0.0065	0.0662	0.2378
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0018	0.0102	0.0367
Echinococcus multilocularis	FTZ F1 alpha	0.0018	0.0102	0.0367
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0018	0.0102	0.0367
Giardia lamblia	Glycerol-3-phosphate dehydrogenase	0.0071	0.0729	1
Brugia malayi	ecdysteroid receptor	0.0018	0.0102	0.0367
Brugia malayi	Nuclear hormone receptor family member nhr-41	0.0018	0.0102	0.0367
Schistosoma mansoni	hypothetical protein	0.0174	0.1962	0.1962
Mycobacterium tuberculosis	Probable D-amino acid oxidase Aao	0.0778	0.9157	1
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0102	0.0102
Mycobacterium tuberculosis	Possible thiamine biosynthesis oxidoreductase ThiO	0.0071	0.0729	0.0719
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0018	0.0102	0.0102
Echinococcus granulosus	voltage gated potassium channel	0.0011	0.0018	0.0066
Echinococcus multilocularis	COUP TF:Svp nuclear hormone receptor	0.0018	0.0102	0.0367
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-40	0.0018	0.0102	0.0102
Echinococcus multilocularis	potassium voltage gated channel subfamily H	0.0011	0.0018	0.0066
Loa Loa (eye worm)	TAR-binding protein	0.0065	0.0662	0.0662
Trypanosoma brucei	FAD dependent oxidoreductase, putative	0.0071	0.0729	1
Schistosoma mansoni	steroid hormone receptor ad4bp	0.0018	0.0102	0.0102
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0283	0.0283
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0018	0.0102	0.0367
Echinococcus granulosus	COUP TF:Svp nuclear hormone receptor	0.0018	0.0102	0.0367
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-49	0.0018	0.0102	0.0102
Mycobacterium leprae	PROBABLE D-AMINO ACID OXIDASE AAO	0.0849	1	1
Brugia malayi	nuclear hormone receptor	0.0018	0.0102	0.0367
Schistosoma mansoni	nuclear hormone receptor nor-1/nor-2	0.0018	0.0102	0.0102
Echinococcus granulosus	histone acetyltransferase KAT2B	0.0142	0.158	0.5678
Echinococcus granulosus	transcription factor Dp 1	0.0039	0.0354	0.1271
Echinococcus granulosus	Nuclear hormone receptor family member nhr 41	0.0018	0.0102	0.0367
Brugia malayi	follicle stimulating hormone receptor	0.0238	0.2723	0.9786
Echinococcus granulosus	dihydrofolate reductase	0.0177	0.1992	0.7157
Echinococcus multilocularis	survival motor neuron protein 1	0.0243	0.2783	1
Brugia malayi	RNA recognition motif domain containing protein	0.0065	0.0662	0.2378
Schistosoma mansoni	fad oxidoreductase	0.0071	0.0729	0.0729
Schistosoma mansoni	nuclear hormone receptor	0.0018	0.0102	0.0102
Schistosoma mansoni	tar DNA-binding protein	0.0065	0.0662	0.0662
Echinococcus multilocularis	voltage gated potassium channel	0.0011	0.0018	0.0066
Schistosoma mansoni	voltage-gated potassium channel	0.0011	0.0018	0.0018
Loa Loa (eye worm)	hypothetical protein	0.0071	0.0729	0.0729
Loa Loa (eye worm)	glycerol-3-phosphate dehydrogenase	0.0071	0.0729	0.0729
Mycobacterium tuberculosis	Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase)	0.0177	0.1992	0.211
Schistosoma mansoni	photoreceptor-specific nuclear receptor related	0.0018	0.0102	0.0102
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0018	0.0102	0.0367
Echinococcus granulosus	FAD dependent oxidoreductase domain containing protein	0.0071	0.0729	0.2618
Loa Loa (eye worm)	RNA recognition domain-containing protein domain-containing protein	0.0065	0.0662	0.0662
Trichomonas vaginalis	bromodomain-containing protein, putative	0.0043	0.0398	1
Mycobacterium ulcerans	thiamine biosynthesis oxidoreductase ThiO	0.0071	0.0729	0.0652
Loa Loa (eye worm)	nuclear Hormone Receptor family member	0.0018	0.0102	0.0102
Loa Loa (eye worm)	hypothetical protein	0.0071	0.0729	0.0729
Trichomonas vaginalis	cat eye syndrome critical region protein 2, cscr2, putative	0.0043	0.0398	1
Trypanosoma cruzi	tyrosyl-DNA Phosphodiesterase (Tdp1), putative	0.0068	0.0694	0.9475
Brugia malayi	RNA binding protein	0.0065	0.0662	0.2378
Brugia malayi	Tyrosyl-DNA phosphodiesterase family protein	0.0068	0.0694	0.2495
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0102	0.0102
Brugia malayi	Nuclear hormone receptor family member nhr-49	0.0018	0.0102	0.0367
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.0238	0.2723	0.2723
Trypanosoma cruzi	cytochrome P450, putative	0.0017	0.0082	0.0104
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0102	0.0102
Trypanosoma cruzi	Present in the outer mitochondrial membrane proteome 20	0.0071	0.0729	1
Brugia malayi	nuclear receptor NHR-88	0.0018	0.0102	0.0367
Brugia malayi	Nuclear hormone receptor family member nhr-1	0.0018	0.0102	0.0367
Loa Loa (eye worm)	voltage and ligand gated potassium channel	0.0038	0.0344	0.0344
Leishmania major	hypothetical protein, conserved	0.0071	0.0729	1
Schistosoma mansoni	voltage-gated potassium channel	0.0042	0.0386	0.0386
Echinococcus granulosus	glycerol 3 phosphate dehydrogenase	0.0071	0.0729	0.2618
Loa Loa (eye worm)	hypothetical protein	0.0071	0.0729	0.0729
Mycobacterium ulcerans	dihydrofolate reductase DfrA	0.0177	0.1992	0.1925
Brugia malayi	Dihydrofolate reductase	0.0177	0.1992	0.7157
Onchocerca volvulus		0.005	0.0476	0.5975
Loa Loa (eye worm)	tyrosyl-DNA phosphodiesterase	0.0068	0.0694	0.0694
Echinococcus granulosus	survival motor neuron protein 1	0.0243	0.2783	1
Brugia malayi	Nuclear hormone receptor family member nhr-40	0.0018	0.0102	0.0367
Schistosoma mansoni	retinoic acid receptor RXR	0.0018	0.0102	0.0102
Leishmania major	glycerol-3-phosphate dehydrogenase-like protein	0.0071	0.0729	1
Echinococcus multilocularis	NADP dependent isocitrate dehydrogenase	0.0016	0.0076	0.0272
Brugia malayi	Cytochrome P450 family protein	0.0017	0.0082	0.0296
Echinococcus multilocularis	hepatocyte nuclear factor 4 alpha	0.0018	0.0102	0.0367
Echinococcus granulosus	tyrosyl DNA phosphodiesterase 1	0.0068	0.0694	0.2495
Echinococcus multilocularis	tar DNA binding protein	0.0065	0.0662	0.2378
Loa Loa (eye worm)	cytochrome P450 family protein	0.0017	0.0082	0.0082
Trypanosoma cruzi	cytochrome P450, putative	0.0017	0.0082	0.0104
Schistosoma mansoni	fad oxidoreductase	0.0071	0.0729	0.0729
Brugia malayi	photoreceptor-specific nuclear receptor	0.0018	0.0102	0.0367
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0018	0.0102	0.0367
Brugia malayi	Isocitrate dehydrogenase	0.0016	0.0076	0.0272
Trypanosoma brucei	dihydrofolate reductase-thymidylate synthase	0.0068	0.0691	0.9421
Trypanosoma brucei	glycerol-3-phosphate dehydrogenase (FAD-dependent), mitochondrial	0.0071	0.0729	1
Trypanosoma cruzi	L-2-hydroxyglutarate dehydrogenase, mitochondrial, putative	0.0071	0.0729	1
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-14	0.0018	0.0102	0.0102
Echinococcus granulosus	FTZ F1 nuclear receptor protein	0.0018	0.0102	0.0367
Trypanosoma cruzi	glycerol-3-phosphate dehydrogenase, putative	0.0071	0.0729	1
Brugia malayi	Nuclear hormone receptor family member nhr-31	0.0018	0.0102	0.0367
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-31	0.0018	0.0102	0.0102
Toxoplasma gondii	hypothetical protein	0.0071	0.0729	1
Brugia malayi	hypothetical protein	0.0243	0.2783	1
Echinococcus granulosus	hepatocyte nuclear factor 4 alpha	0.0018	0.0102	0.0367
Brugia malayi	steroid hormone receptor	0.0018	0.0102	0.0367
Schistosoma mansoni	hypothetical protein	0.005	0.0476	0.0476
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-1	0.0018	0.0102	0.0102
Echinococcus multilocularis	isocitrate dehydrogenase 2 (NADP+)	0.0016	0.0076	0.0272
Toxoplasma gondii	bifunctional dihydrofolate reductase-thymidylate synthase	0.0068	0.0691	0.9421
Brugia malayi	acetyltransferase, GNAT family protein	0.0146	0.1629	0.5854
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0018	0.0102	0.0367
Plasmodium falciparum	histone acetyltransferase GCN5	0.0039	0.0356	0.4287
Echinococcus multilocularis	geminin	0.0174	0.1962	0.7049
Leishmania major	tyrosyl-DNA phosphodiesterase 1	0.0068	0.0694	0.9475
Brugia malayi	Nuclear hormone receptor family member nhr-14	0.0018	0.0102	0.0367
Schistosoma mansoni	Tr4/Tr2 (homologue)	0.0018	0.0102	0.0102
Brugia malayi	Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog	0.0011	0.0018	0.0066
Brugia malayi	RE18450p	0.0071	0.0729	0.2618
Leishmania major	hypothetical protein, conserved	0.0071	0.0729	1
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0018	0.0102	0.0367
Schistosoma mansoni	thyroid hormone receptor	0.0018	0.0102	0.0102
Brugia malayi	cDNA sequence BC016226	0.0071	0.0729	0.2618
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0102	0.0102
Echinococcus granulosus	geminin	0.0174	0.1962	0.7049

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

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Bibliographic References

No literature references available for this target.

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Detailed information for compound 864239