Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | voltage-gated potassium channel | 0.0177 | 0.0821 | 0.0821 |
Schistosoma mansoni | sodium-dependent neurotransmitter transporter | 0.0322 | 0.1595 | 0.1595 |
Echinococcus multilocularis | potassium voltage gated channel subfamily H | 0.0047 | 0.0127 | 0.0127 |
Trypanosoma brucei | glycerol-3-phosphate dehydrogenase (FAD-dependent), mitochondrial | 0.0155 | 0.0705 | 1 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0026 | 0.0012 | 0.0012 |
Echinococcus granulosus | neuropeptide receptor A26 | 0.0522 | 0.2666 | 0.2666 |
Schistosoma mansoni | norepinephrine/norepinephrine transporter | 0.0322 | 0.1595 | 0.1595 |
Schistosoma mansoni | cyclic-nucleotide-gated cation channel | 0.0032 | 0.0047 | 0.0047 |
Echinococcus granulosus | FAD dependent oxidoreductase domain containing protein | 0.0155 | 0.0705 | 0.0705 |
Echinococcus granulosus | glycerol 3 phosphate dehydrogenase | 0.0155 | 0.0705 | 0.0705 |
Trypanosoma cruzi | glycerol-3-phosphate dehydrogenase (FAD-dependent), putative | 0.0155 | 0.0705 | 1 |
Loa Loa (eye worm) | glycerol-3-phosphate dehydrogenase | 0.0155 | 0.0705 | 0.0705 |
Brugia malayi | Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog | 0.0162 | 0.0741 | 0.0741 |
Loa Loa (eye worm) | hypothetical protein | 0.0322 | 0.1595 | 0.1595 |
Schistosoma mansoni | fad oxidoreductase | 0.0155 | 0.0705 | 0.0705 |
Schistosoma mansoni | norepinephrine/norepinephrine transporter | 0.0322 | 0.1595 | 0.1595 |
Loa Loa (eye worm) | hypothetical protein | 0.0322 | 0.1595 | 0.1595 |
Echinococcus granulosus | uncharacterized sodium dependent transporter | 0.0322 | 0.1595 | 0.1595 |
Brugia malayi | pyruvate dehydrogenase phosphatase regulatory subunit precursor | 0.0155 | 0.0705 | 0.0705 |
Mycobacterium tuberculosis | Probable aldehyde dehydrogenase | 0.0069 | 0.0242 | 0.0269 |
Echinococcus multilocularis | uncharacterized sodium dependent transporter | 0.0322 | 0.1595 | 0.1595 |
Echinococcus granulosus | cyclic nucleotide gated cation channel | 0.0032 | 0.0047 | 0.0047 |
Echinococcus granulosus | cyclic nucleotide gated cation channel | 0.0032 | 0.0047 | 0.0047 |
Trichomonas vaginalis | voltage and ligand gated potassium channel, putative | 0.0151 | 0.0684 | 1 |
Schistosoma mansoni | d-amino acid oxidase | 0.1863 | 0.9824 | 0.9824 |
Plasmodium vivax | amine transporter, putative | 0.0322 | 0.1595 | 1 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0047 | 0.0127 | 0.0127 |
Brugia malayi | Abnormal catecholamine distribution protein 1 | 0.0184 | 0.0861 | 0.0861 |
Loa Loa (eye worm) | hypothetical protein | 0.0322 | 0.1595 | 0.1595 |
Leishmania major | hypothetical protein, conserved | 0.0155 | 0.0705 | 1 |
Echinococcus multilocularis | neuropeptide s receptor | 0.0522 | 0.2666 | 0.2666 |
Mycobacterium leprae | PROBABLE D-AMINO ACID OXIDASE AAO | 0.1863 | 0.9824 | 1 |
Echinococcus multilocularis | hyperpolarization activated cyclic | 0.0032 | 0.0047 | 0.0047 |
Echinococcus granulosus | sodium dependent neurotransmitter transporter | 0.0322 | 0.1595 | 0.1595 |
Echinococcus granulosus | uncharacterized sodium dependent transporter | 0.0322 | 0.1595 | 0.1595 |
Loa Loa (eye worm) | norepinephrine transporter | 0.1896 | 1 | 1 |
Brugia malayi | Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog | 0.0047 | 0.0127 | 0.0127 |
Trypanosoma cruzi | glycerol-3-phosphate dehydrogenase (FAD-dependent), putative | 0.0155 | 0.0705 | 1 |
Brugia malayi | hypothetical protein | 0.0138 | 0.0615 | 0.0615 |
Schistosoma mansoni | sodium-dependent neurotransmitter transporter | 0.0322 | 0.1595 | 0.1595 |
Toxoplasma gondii | Sodium:neurotransmitter symporter family protein | 0.0322 | 0.1595 | 1 |
Loa Loa (eye worm) | abnormal catecholamine distribution protein 1 | 0.0184 | 0.0861 | 0.0861 |
Mycobacterium ulcerans | D-amino acid oxidase Aao | 0.1863 | 0.9824 | 1 |
Schistosoma mansoni | ATP:guanidino kinase (Smc74) | 0.0155 | 0.0705 | 0.0705 |
Schistosoma mansoni | sodium/chloride dependent neurotransmitter transporter | 0.0322 | 0.1595 | 0.1595 |
Schistosoma mansoni | sodium/chloride dependent neurotransmitter transporter | 0.0322 | 0.1595 | 0.1595 |
Onchocerca volvulus | 0.0322 | 0.1595 | 0.1044 | |
Onchocerca volvulus | Pyruvate dehydrogenase phosphatase regulatory subunit, mitochondrial homolog | 0.0155 | 0.0705 | 0.0096 |
Echinococcus multilocularis | potassium voltage gated channel subfamily H | 0.0162 | 0.0741 | 0.0741 |
Plasmodium falciparum | transporter, putative | 0.0322 | 0.1595 | 1 |
Entamoeba histolytica | anaerobic glycerol-3-phosphate dehydrogenase subunit A, putative | 0.0155 | 0.0705 | 0.5 |
Trichomonas vaginalis | voltage and ligand gated potassium channel, putative | 0.0151 | 0.0684 | 1 |
Schistosoma mansoni | sodium-dependent amino acid transporter | 0.0322 | 0.1595 | 0.1595 |
Schistosoma mansoni | hyperpolarization activated cyclic nucleotide-gated potassium channel | 0.0032 | 0.0047 | 0.0047 |
Schistosoma mansoni | sodium-dependent neurotransmitter transporter | 0.0322 | 0.1595 | 0.1595 |
Echinococcus granulosus | serotonin transporter | 0.1896 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0155 | 0.0705 | 0.0705 |
Echinococcus multilocularis | serotonin transporter | 0.1896 | 1 | 1 |
Loa Loa (eye worm) | Sodium:neurotransmitter symporter family protein | 0.0322 | 0.1595 | 0.1595 |
Loa Loa (eye worm) | hypothetical protein | 0.0138 | 0.0615 | 0.0615 |
Toxoplasma gondii | Sodium:neurotransmitter symporter family protein | 0.0322 | 0.1595 | 1 |
Trypanosoma brucei | electron transfer flavoprotein-ubiquinone oxidoreductase, putative | 0.0155 | 0.0705 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0155 | 0.0705 | 0.0705 |
Loa Loa (eye worm) | hypothetical protein | 0.1896 | 1 | 1 |
Mycobacterium ulcerans | glycerol-3-phosphate dehydrogenase GlpD2 | 0.0155 | 0.0705 | 0.0718 |
Echinococcus multilocularis | FAD dependent oxidoreductase domain containing protein | 0.0155 | 0.0705 | 0.0705 |
Brugia malayi | RE18450p | 0.0155 | 0.0705 | 0.0705 |
Brugia malayi | Sodium:neurotransmitter symporter family protein | 0.0322 | 0.1595 | 0.1595 |
Trypanosoma cruzi | glycerol-3-phosphate dehydrogenase, putative | 0.0155 | 0.0705 | 1 |
Toxoplasma gondii | aldehyde dehydrogenase | 0.0069 | 0.0242 | 0.1519 |
Mycobacterium ulcerans | thiamine biosynthesis oxidoreductase ThiO | 0.0155 | 0.0705 | 0.0718 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0069 | 0.0242 | 0.0242 |
Trypanosoma cruzi | L-2-hydroxyglutarate dehydrogenase, mitochondrial, putative | 0.0155 | 0.0705 | 1 |
Echinococcus multilocularis | sodium and chloride dependent glycine | 0.0322 | 0.1595 | 0.1595 |
Chlamydia trachomatis | Ssodium-dependent amino acid transporter | 0.0322 | 0.1595 | 1 |
Entamoeba histolytica | NAD(FAD)-dependent dehydrogenase, putative | 0.0155 | 0.0705 | 0.5 |
Echinococcus multilocularis | voltage gated potassium channel | 0.0047 | 0.0127 | 0.0127 |
Schistosoma mansoni | sodium/chloride dependent transporter | 0.0322 | 0.1595 | 0.1595 |
Brugia malayi | Sodium:neurotransmitter symporter family protein | 0.0322 | 0.1595 | 0.1595 |
Schistosoma mansoni | cyclic-nucleotide-gated cation channel | 0.0032 | 0.0047 | 0.0047 |
Echinococcus granulosus | hyperpolarization activated cyclic | 0.0032 | 0.0047 | 0.0047 |
Loa Loa (eye worm) | hypothetical protein | 0.0047 | 0.0127 | 0.0127 |
Echinococcus granulosus | sodium and chloride dependent glycine | 0.0322 | 0.1595 | 0.1595 |
Giardia lamblia | Glycerol-3-phosphate dehydrogenase | 0.0155 | 0.0705 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0141 | 0.0627 | 0.0627 |
Loa Loa (eye worm) | cyclic-nucleotide gated cation channel | 0.0032 | 0.0047 | 0.0047 |
Echinococcus multilocularis | glycerol 3 phosphate dehydrogenase | 0.0155 | 0.0705 | 0.0705 |
Leishmania major | aldehyde dehydrogenase, mitochondrial precursor | 0.0069 | 0.0242 | 0.3435 |
Echinococcus multilocularis | sodium dependent neurotransmitter transporter | 0.0322 | 0.1595 | 0.1595 |
Trypanosoma brucei | FAD dependent oxidoreductase, putative | 0.0155 | 0.0705 | 1 |
Toxoplasma gondii | FAD-dependent glycerol-3-phosphate dehydrogenase | 0.0155 | 0.0705 | 0.4422 |
Onchocerca volvulus | 0.1896 | 1 | 1 | |
Schistosoma mansoni | sodium/chloride dependent transporter | 0.0322 | 0.1595 | 0.1595 |
Treponema pallidum | sodium- and chloride- dependent transporter | 0.1896 | 1 | 0.5 |
Schistosoma mansoni | hyperpolarization activated cyclic nucleotide-gated potassium channel | 0.0032 | 0.0047 | 0.0047 |
Echinococcus multilocularis | aldehyde dehydrogenase, mitochondrial | 0.0069 | 0.0242 | 0.0242 |
Toxoplasma gondii | hypothetical protein | 0.0155 | 0.0705 | 0.4422 |
Schistosoma mansoni | glycerol-3-phosphate dehydrogenase | 0.0155 | 0.0705 | 0.0705 |
Echinococcus granulosus | cyclic nucleotide gated cation channel alpha 3 | 0.0032 | 0.0047 | 0.0047 |
Toxoplasma gondii | hypothetical protein | 0.0322 | 0.1595 | 1 |
Mycobacterium tuberculosis | Possible thiamine biosynthesis oxidoreductase ThiO | 0.0155 | 0.0705 | 0.0784 |
Loa Loa (eye worm) | hypothetical protein | 0.0138 | 0.0615 | 0.0615 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0069 | 0.0242 | 0.0247 |
Loa Loa (eye worm) | cyclic-nucleotide gated cation channel | 0.0032 | 0.0047 | 0.0047 |
Echinococcus granulosus | aldehyde dehydrogenase mitochondrial | 0.0069 | 0.0242 | 0.0242 |
Brugia malayi | hypothetical protein | 0.0322 | 0.1595 | 0.1595 |
Loa Loa (eye worm) | solute carrier family 6 member 4 | 0.1896 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0322 | 0.1595 | 0.1595 |
Loa Loa (eye worm) | hypothetical protein | 0.1863 | 0.9824 | 0.9824 |
Loa Loa (eye worm) | hypothetical protein | 0.0322 | 0.1595 | 0.1595 |
Onchocerca volvulus | 0.0322 | 0.1595 | 0.1044 | |
Onchocerca volvulus | Dimethylglycine dehydrogenase, mitochondrial homolog | 0.0155 | 0.0705 | 0.0096 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0032 | 0.0047 | 0.0047 |
Echinococcus granulosus | sodium:chloride dependent neurotransmitter | 0.0322 | 0.1595 | 0.1595 |
Trypanosoma brucei | L-2-hydroxyglutarate dehydrogenase, mitochondrial, putative | 0.0155 | 0.0705 | 1 |
Schistosoma mansoni | norepinephrine/norepinephrine transporter | 0.1896 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.1896 | 1 | 1 |
Schistosoma mansoni | fad oxidoreductase | 0.0155 | 0.0705 | 0.0705 |
Echinococcus multilocularis | hyperpolarization activated cyclic | 0.0032 | 0.0047 | 0.0047 |
Echinococcus granulosus | voltage gated potassium channel | 0.0047 | 0.0127 | 0.0127 |
Loa Loa (eye worm) | hypothetical protein | 0.0032 | 0.0047 | 0.0047 |
Plasmodium falciparum | amino acid transporter, putative | 0.0322 | 0.1595 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.1896 | 1 | 1 |
Echinococcus granulosus | potassium:sodium hyperpolarization activated | 0.0032 | 0.0047 | 0.0047 |
Loa Loa (eye worm) | voltage and ligand gated potassium channel | 0.0162 | 0.0741 | 0.0741 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0069 | 0.0242 | 0.0247 |
Trypanosoma cruzi | L-2-hydroxyglutarate dehydrogenase, mitochondrial, putative | 0.0155 | 0.0705 | 1 |
Trypanosoma brucei | glycerol-3-phosphate dehydrogenase (FAD-dependent), putative | 0.0155 | 0.0705 | 1 |
Brugia malayi | dimethylglycine dehydrogenase, mitochondrial precursor, putative | 0.0155 | 0.0705 | 0.0705 |
Plasmodium vivax | hypothetical protein, conserved | 0.0322 | 0.1595 | 1 |
Toxoplasma gondii | hypothetical protein | 0.0322 | 0.1595 | 1 |
Onchocerca volvulus | Putative fad oxidoreductase | 0.0155 | 0.0705 | 0.0096 |
Schistosoma mansoni | sodium/chloride dependent neurotransmitter transporter | 0.0322 | 0.1595 | 0.1595 |
Mycobacterium ulcerans | glycerol-3-phosphate dehydrogenase | 0.0155 | 0.0705 | 0.0718 |
Schistosoma mansoni | vesicular amine transporter | 0.0184 | 0.0861 | 0.0861 |
Echinococcus granulosus | potassium voltage gated channel subfamily H | 0.0047 | 0.0127 | 0.0127 |
Schistosoma mansoni | sodium/chloride dependent transporter | 0.1896 | 1 | 1 |
Echinococcus granulosus | potassium voltage gated channel subfamily H | 0.0162 | 0.0741 | 0.0741 |
Leishmania major | hypothetical protein, conserved | 0.0155 | 0.0705 | 1 |
Echinococcus granulosus | neuropeptide s receptor | 0.0522 | 0.2666 | 0.2666 |
Mycobacterium tuberculosis | Probable D-amino acid oxidase Aao | 0.1708 | 0.8994 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0322 | 0.1595 | 0.1595 |
Mycobacterium leprae | Probable cholesterol oxidase precursor ChoD (cholesterol-O2 oxidoreductase) | 0.0155 | 0.0705 | 0.0718 |
Loa Loa (eye worm) | Sodium:neurotransmitter symporter family protein | 0.0322 | 0.1595 | 0.1595 |
Echinococcus multilocularis | synaptic vesicular amine transporter | 0.0184 | 0.0861 | 0.0861 |
Echinococcus granulosus | hyperpolarization activated cyclic | 0.0032 | 0.0047 | 0.0047 |
Loa Loa (eye worm) | hypothetical protein | 0.0322 | 0.1595 | 0.1595 |
Leishmania major | glycerol-3-phosphate dehydrogenase-like protein | 0.0155 | 0.0705 | 1 |
Trypanosoma cruzi | FAD dependent oxidoreductase, putative | 0.0155 | 0.0705 | 1 |
Brugia malayi | Cyclic-nucleotide gated cation channel | 0.0032 | 0.0047 | 0.0047 |
Onchocerca volvulus | 0.0322 | 0.1595 | 0.1044 | |
Loa Loa (eye worm) | serotonin transporter b | 0.1896 | 1 | 1 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0069 | 0.0242 | 0.0247 |
Toxoplasma gondii | Sodium:neurotransmitter symporter family protein | 0.0322 | 0.1595 | 1 |
Schistosoma mansoni | cyclic-nucleotide-gated cation channel | 0.0032 | 0.0047 | 0.0047 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0069 | 0.0242 | 0.0242 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0177 | 0.0821 | 0.0821 |
Brugia malayi | Sodium:neurotransmitter symporter family protein | 0.0322 | 0.1595 | 0.1595 |
Brugia malayi | cDNA sequence BC016226 | 0.0155 | 0.0705 | 0.0705 |
Loa Loa (eye worm) | hypothetical protein | 0.0155 | 0.0705 | 0.0705 |
Echinococcus multilocularis | cyclic nucleotide gated cation channel | 0.0032 | 0.0047 | 0.0047 |
Echinococcus multilocularis | neuropeptide receptor A26 | 0.0522 | 0.2666 | 0.2666 |
Mycobacterium leprae | Possible thiamine biosynthesis oxidoreductase ThiO | 0.0155 | 0.0705 | 0.0718 |
Echinococcus multilocularis | cyclic nucleotide gated cation channel alpha 3 | 0.0032 | 0.0047 | 0.0047 |
Echinococcus multilocularis | sodium:chloride dependent neurotransmitter | 0.0322 | 0.1595 | 0.1595 |
Trypanosoma cruzi | Present in the outer mitochondrial membrane proteome 20 | 0.0155 | 0.0705 | 1 |
Schistosoma mansoni | NAD dehydrogenase | 0.0155 | 0.0705 | 0.0705 |
Mycobacterium ulcerans | D-amino acid oxidase Aao | 0.0155 | 0.0705 | 0.0718 |
Echinococcus granulosus | sodium and chloride dependent glycine | 0.0322 | 0.1595 | 0.1595 |
Echinococcus granulosus | synaptic vesicular amine transporter | 0.0184 | 0.0861 | 0.0861 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0047 | 0.0127 | 0.0127 |
Schistosoma mansoni | 60S ribosomal protein L21 | 0.0026 | 0.0012 | 0.0012 |
Echinococcus multilocularis | potassium:sodium hyperpolarization activated | 0.0032 | 0.0047 | 0.0047 |
Brugia malayi | Sodium:neurotransmitter symporter family protein 1, putative | 0.0322 | 0.1595 | 0.1595 |
Echinococcus multilocularis | sodium and chloride dependent glycine | 0.0322 | 0.1595 | 0.1595 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.