TDR Targets

Basic information

Technical information

TDR Targets ID: 879189
Name: 3-(2-methoxy-5-methylphenyl)-1-[[3-(trifluoro methoxy)phenyl]methyl]urea
MW: 354.324 | Formula: C17H17F3N2O3
H donors: 2 H acceptors: 1 LogP: 3.94 Rotable bonds: 8
Rule of 5 violations (Lipinski): 1
SMILES: COc1ccc(cc1NC(=O)NCc1cccc(c1)OC(F)(F)F)C
InChi: 1S/C17H17F3N2O3/c1-11-6-7-15(24-2)14(8-11)22-16(23)21-10-12-4-3-5-13(9-12)25-17(18,19)20/h3-9H,10H2,1-2H3,(H2,21,22,23)
InChiKey: FLAUUUKQVNFZEK-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

3-(2-methoxy-5-methyl-phenyl)-1-[[3-(trifluoromethoxy)phenyl]methyl]urea
3-(2-methoxy-5-methyl-phenyl)-1-[3-(trifluoromethoxy)benzyl]urea

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Brugia malayi	serine/threonine protein kinase 6	0.0075	0.1845	0.1845
Loa Loa (eye worm)	TK/FER protein kinase	0.0019	0.0194	0.0194
Trichomonas vaginalis	AGC family protein kinase	0.0023	0.0318	0.0111
Loa Loa (eye worm)	AGC/RSK/MSK protein kinase	0.0022	0.027	0.027
Schistosoma mansoni	serine/threonine protein kinase	0.0016	0.0108	0.0097
Brugia malayi	SH2 domain containing protein	0.0019	0.0194	0.0194
Echinococcus granulosus	dual specificity protein kinase clk2	0.008	0.1986	0.1977
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0271	0.0271
Trichomonas vaginalis	CMGC family protein kinase	0.0166	0.4532	1
Loa Loa (eye worm)	TK/ABL protein kinase	0.0019	0.0194	0.0194
Echinococcus multilocularis	Immunoglobulin	0.0014	0.0037	0.0026
Loa Loa (eye worm)	hypothetical protein	0.0162	0.4413	0.4413
Brugia malayi	Death domain containing protein	0.002	0.0232	0.0232
Onchocerca volvulus		0.0019	0.0194	0.0183
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0013	0.0011	0.0011
Echinococcus multilocularis	Ribosomal protein S6 kinase beta 2	0.0022	0.027	0.0259
Loa Loa (eye worm)	CAMK/PIM protein kinase	0.0351	1	1
Loa Loa (eye worm)	sex muscle abnormal protein 5	0.0023	0.0321	0.0321
Loa Loa (eye worm)	CMGC/CK2 protein kinase	0.0166	0.4532	0.4532
Echinococcus granulosus	neuroglian	0.0017	0.014	0.0129
Echinococcus granulosus	tyrosine kinase	0.0019	0.0194	0.0183
Trypanosoma cruzi	STE/STE11 serine/threonine-protein kinase, putative	0.0016	0.0121	0.0125
Echinococcus multilocularis	Immunoglobulin	0.0014	0.0037	0.0026
Trichomonas vaginalis	STE family protein kinase	0.0128	0.342	0.739
Echinococcus multilocularis	tyrosine protein kinase Blk	0.0019	0.0194	0.0183
Echinococcus granulosus	death domain containing protein	0.002	0.0232	0.0221
Entamoeba histolytica	protein kinase domain containing protein	0.0075	0.1845	0.4045
Plasmodium vivax	serine/threonine kinase-1, putative	0.008	0.1986	0.0522
Echinococcus granulosus	tyrosine protein kinase Fyn	0.003	0.0533	0.0522
Schistosoma mansoni	serine/threonine protein kinase	0.008	0.1986	0.1977
Schistosoma mansoni	tyrosine kinase	0.0062	0.1467	0.1458
Schistosoma mansoni	tyrosine kinase	0.01	0.2591	0.2583
Echinococcus multilocularis	ribosomal protein S6 kinase alpha 3	0.0022	0.027	0.0259
Brugia malayi	Protein kinase domain containing protein	0.0018	0.017	0.017
Trichomonas vaginalis	CMGC family protein kinase	0.0166	0.4532	1
Echinococcus granulosus	neurotracting:lsamp:neurotrimin:obcam	0.0018	0.0168	0.0157
Echinococcus multilocularis	protein tyrosine kinase	0.0302	0.8559	0.8558
Echinococcus multilocularis	casein kinase ii subunit alpha	0.0166	0.4532	0.4526
Loa Loa (eye worm)	CAMK/MLCK protein kinase	0.0013	0.0011	0.0011
Echinococcus granulosus	arf GAP with SH3 domain ANK repeat and PH	0.0013	0.0021	0.0009
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0037	0.0037
Entamoeba histolytica	serine/threonine- protein kinase 6, putative	0.0075	0.1845	0.4045
Echinococcus granulosus	NCK adaptor protein	0.0023	0.0321	0.031
Echinococcus multilocularis	serine:threonine protein kinase MRCK beta	0.0018	0.017	0.0159
Echinococcus granulosus	mitogen-activated protein kinase kinase kinase 9	0.0115	0.3037	0.3029
Echinococcus multilocularis	tyrosine protein kinase ABL1	0.0019	0.0194	0.0183
Echinococcus multilocularis	guanine nucleotide exchange factor VAV2	0.0021	0.0244	0.0233
Schistosoma mansoni	hypothetical protein	0.002	0.0232	0.0221
Schistosoma mansoni	tyrosine kinase	0.0093	0.2379	0.2371
Onchocerca volvulus	Netrin receptor homolog	0.0024	0.0335	0.0324
Loa Loa (eye worm)	AGC/AKT protein kinase	0.0023	0.0318	0.0318
Brugia malayi	Protein kinase domain containing protein	0.008	0.1986	0.1986
Echinococcus multilocularis	proto oncogene serine:threonine protein kinase	0.0351	1	1
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0037	0.0037
Loa Loa (eye worm)	hypothetical protein	0.0162	0.4413	0.4413
Schistosoma mansoni	cell adhesion molecule	0.0018	0.0168	0.0157
Trypanosoma cruzi	STE/STE11 serine/threonine-protein kinase, putative	0.0016	0.0121	0.0125
Brugia malayi	Serine/threonine-protein kinase Pim-3	0.0351	1	1
Loa Loa (eye worm)	AGC/DMPK/GEK protein kinase	0.0022	0.027	0.027
Echinococcus granulosus	aurora kinase A	0.0075	0.1845	0.1836
Echinococcus granulosus	tyrosine protein kinase shark	0.0019	0.0194	0.0183
Brugia malayi	Hr1 repeat family protein	0.0022	0.027	0.027
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0228	0.6353	0.6353
Loa Loa (eye worm)	AGC/NDR protein kinase	0.0022	0.027	0.027
Leishmania major	protein kinase, putative	0.0016	0.0121	0.0125
Echinococcus granulosus	protein kinase c epsilon type	0.003	0.0532	0.0521
Loa Loa (eye worm)	TK/FER protein kinase	0.0019	0.0194	0.0194
Brugia malayi	SRC-1	0.003	0.0533	0.0533
Echinococcus granulosus	tyrosine protein kinase Btk29A	0.0186	0.5125	0.512
Entamoeba histolytica	protein kinase , putative	0.0075	0.1845	0.4045
Brugia malayi	serine/threonine kinase 12	0.0075	0.1845	0.1845
Entamoeba histolytica	protein kinase, putative	0.0128	0.342	0.7534
Loa Loa (eye worm)	STE/STE20/YSK protein kinase	0.0128	0.342	0.342
Trichomonas vaginalis	AGC family protein kinase	0.0023	0.0318	0.0111
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0037	0.0037
Entamoeba histolytica	protein kinase, putative	0.0021	0.0256	0.0521
Schistosoma mansoni	serine/threonine protein kinase	0.0039	0.0786	0.0775
Loa Loa (eye worm)	TK/FER protein kinase	0.0019	0.0194	0.0194
Onchocerca volvulus	Tyrosine kinase homolog	0.0213	0.5922	0.5918
Trypanosoma cruzi	casein kinase II, putative	0.0166	0.4532	1
Schistosoma mansoni	chimerin-related rho-gtpase-activating protein	0.0021	0.0244	0.0233
Leishmania major	protein kinase, putative	0.0075	0.1845	0.3986
Echinococcus multilocularis		0.007	0.1712	0.1703
Loa Loa (eye worm)	hypothetical protein	0.005	0.1109	0.1109
Plasmodium falciparum	serine/threonine protein kinase, putative	0.0075	0.1845	0.391
Echinococcus granulosus	serine threonine protein kinase	0.0128	0.342	0.3412
Brugia malayi	SH2 domain containing protein	0.0019	0.0194	0.0194
Brugia malayi	Protein kinase c protein 2	0.0018	0.017	0.017
Echinococcus multilocularis	tyrosine protein kinase Fgr	0.003	0.0533	0.0522
Echinococcus granulosus	Immunoglobulin	0.0014	0.0037	0.0026
Echinococcus multilocularis	neuroglian	0.0017	0.014	0.0129
Echinococcus multilocularis	tyrosine protein kinase Src42A	0.003	0.0533	0.0522
Echinococcus granulosus	intersectin 2	0.0015	0.0065	0.0054
Echinococcus granulosus	NDR protein kinase	0.0022	0.027	0.0259
Echinococcus multilocularis	Protein kinase C, brain isozyme	0.003	0.0532	0.0521
Entamoeba histolytica	protein kinase, putative	0.0022	0.027	0.0553
Echinococcus multilocularis	tyrosine protein kinase Abl	0.003	0.0533	0.0522
Trichomonas vaginalis	AGC family protein kinase	0.0075	0.1845	0.3696
Schistosoma mansoni	tyrosine kinase	0.0093	0.2379	0.2371
Echinococcus granulosus	protein kinase C gamma type	0.0022	0.027	0.0259
Schistosoma mansoni	atypical protein kinase C	0.003	0.0532	0.0521
Echinococcus granulosus	casein kinase ii subunit alpha	0.0166	0.4532	0.4526
Echinococcus granulosus	melanoma receptor tyrosine protein kinase	0.01	0.2591	0.2583
Trichomonas vaginalis	AGC family protein kinase	0.0023	0.0318	0.0111
Echinococcus multilocularis	ribosomal protein s6 kinase beta 1	0.0022	0.027	0.0259
Echinococcus granulosus	netrin receptor unc 5	0.0025	0.0363	0.0352
Echinococcus multilocularis	mitogen activated protein kinase kinase kinase	0.0115	0.3037	0.3029
Echinococcus granulosus	tyrosine protein kinase Fyn	0.003	0.0533	0.0522
Echinococcus multilocularis	epidermal growth factor receptor	0.0181	0.4981	0.4975
Echinococcus multilocularis	intersectin 2	0.0015	0.0065	0.0054
Echinococcus multilocularis	tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase	0.003	0.0533	0.0522
Loa Loa (eye worm)	AUR protein kinase	0.0075	0.1845	0.1845
Onchocerca volvulus		0.0019	0.0194	0.0183
Schistosoma mansoni	serine/threonine protein kinase	0.0022	0.027	0.0259
Brugia malayi	Protein kinase domain containing protein	0.0023	0.0318	0.0318
Echinococcus granulosus	ribosomal protein s6 kinase beta 1	0.0022	0.027	0.0259
Echinococcus granulosus	Serine/threonine-protein kinase Genghis Khan	0.0018	0.017	0.0159
Echinococcus multilocularis	dual specificity protein kinase clk2	0.008	0.1986	0.1977
Echinococcus multilocularis	tyrosine protein kinase Btk29A	0.0186	0.5125	0.512
Brugia malayi	Protein kinase domain containing protein	0.0306	0.8663	0.8663
Loa Loa (eye worm)	AUR protein kinase	0.0075	0.1845	0.1845
Trypanosoma cruzi	aurora B kinase, putative	0.0075	0.1845	0.3986
Brugia malayi	protein kinase C II.	0.003	0.0532	0.0532
Entamoeba histolytica	protein kinase, putative	0.0023	0.0318	0.0658
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.003	0.0533	0.0522
Echinococcus multilocularis	arf GAP with SH3 domain, ANK repeat and PH	0.0013	0.0021	0.0009
Trypanosoma cruzi	kinetoplastid kinetochore protein 19, putative	0.008	0.1986	0.43
Schistosoma mansoni	serine/threonine protein kinase	0.0018	0.017	0.0159
Echinococcus multilocularis	tyrosine protein kinase Fps85D	0.0019	0.0194	0.0183
Schistosoma mansoni	growth factor receptor-bound protein	0.0026	0.0412	0.0402
Schistosoma mansoni	growth factor receptor-bound protein	0.0023	0.0321	0.031
Echinococcus granulosus	serine:threonine protein kinase N2	0.0022	0.027	0.0259
Echinococcus multilocularis	tyrosine protein kinase Srms	0.0019	0.0194	0.0183
Entamoeba histolytica	casein kinase, putative	0.0166	0.4532	1
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0025	0.0363	0.0363
Echinococcus granulosus	hypothetical protein	0.007	0.1712	0.1703
Echinococcus granulosus	twitchin	0.0026	0.0414	0.0403
Schistosoma mansoni	protein kinase C mu	0.0018	0.017	0.0159
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0014	0.0037	0.0037
Echinococcus granulosus	defective proboscis extension response	0.0014	0.0037	0.0026
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0037	0.0037
Loa Loa (eye worm)	hypothetical protein	0.0039	0.0786	0.0786
Giardia lamblia	Kinase, CMGC CK2	0.0166	0.4532	1
Trypanosoma brucei	aurora B kinase	0.0075	0.1845	0.391
Loa Loa (eye worm)	TK/EGFR protein kinase	0.0181	0.4981	0.4981
Brugia malayi	Protein kinase domain containing protein	0.0059	0.1383	0.1383
Trichomonas vaginalis	AGC family protein kinase	0.0023	0.0318	0.0111
Echinococcus multilocularis	insulin receptor	0.0062	0.1467	0.1458
Echinococcus multilocularis	netrin receptor unc 5	0.0025	0.0363	0.0352
Trypanosoma cruzi	kinetoplastid kinetochore protein 10, putative	0.008	0.1986	0.43
Echinococcus granulosus	proto oncogene serine:threonine protein kinase	0.0351	1	1
Echinococcus multilocularis	serine:threonine protein kinase N2	0.0022	0.027	0.0259
Loa Loa (eye worm)	hypothetical protein	0.003	0.0513	0.0513
Trypanosoma brucei	Casein kinase II	0.0166	0.4532	1
Schistosoma mansoni	adapter molecule crk	0.0023	0.0321	0.031
Onchocerca volvulus		0.0015	0.0065	0.0054
Leishmania major	casein kinase II, putative	0.0166	0.4532	1
Echinococcus granulosus	epidermal growth factor receptor	0.0181	0.4981	0.4975
Echinococcus multilocularis		0.0054	0.1233	0.1223
Brugia malayi	Variant SH3 domain containing protein	0.0021	0.0244	0.0244
Entamoeba histolytica	protein kinase, putative	0.0075	0.1845	0.4045
Loa Loa (eye worm)	AGC/RSK/P70 protein kinase	0.0022	0.027	0.027
Echinococcus granulosus	serine:threonine protein kinase 12 B	0.0075	0.1845	0.1836
Brugia malayi	hypothetical protein	0.0019	0.0194	0.0194
Loa Loa (eye worm)	TK/FER protein kinase	0.0019	0.0194	0.0194
Schistosoma mansoni	proto-oncogene tyrosine-protein kinase abl1	0.0023	0.0321	0.031
Echinococcus multilocularis	serine threonine protein kinase	0.0022	0.027	0.0259
Echinococcus granulosus	guanine nucleotide exchange factor VAV2	0.0021	0.0244	0.0233
Loa Loa (eye worm)	CAMK/DAPK/DAPK protein kinase	0.0039	0.0786	0.0786
Schistosoma mansoni	defective proboscis extension response (dpr)-related	0.0014	0.0037	0.0026
Echinococcus granulosus	c src tyrosine kinase	0.003	0.0533	0.0522
Schistosoma mansoni	serine/threonine kinase	0.0022	0.027	0.0259
Echinococcus multilocularis	basement membrane specific heparan sulfate	0.0014	0.0037	0.0026
Echinococcus granulosus	raf serine:threonine protein kinase	0.0016	0.0108	0.0097
Brugia malayi	Protein kinase domain containing protein	0.0022	0.027	0.027
Loa Loa (eye worm)	TK/INSR protein kinase	0.0062	0.1467	0.1467
Schistosoma mansoni	tyrosine kinase	0.0019	0.0194	0.0183
Entamoeba histolytica	protein kinase, putative	0.0075	0.1845	0.4045
Echinococcus multilocularis	growth factor receptor bound protein 2	0.0023	0.0321	0.031
Echinococcus multilocularis	tyrosine protein kinase shark	0.0019	0.0194	0.0183
Loa Loa (eye worm)	variant SH3 domain-containing protein	0.0023	0.0321	0.0321
Echinococcus multilocularis	serine:threonine protein kinase 38	0.0022	0.027	0.0259
Schistosoma mansoni	retinoblastoma-binding protein 4 (rbbp4)	0.002	0.0232	0.0221
Echinococcus granulosus	Ankyrin	0.002	0.0232	0.0221
Echinococcus multilocularis	Ankyrin	0.002	0.0233	0.0222
Leishmania major	protein kinase, putative	0.008	0.1986	0.43
Schistosoma mansoni	nephrin	0.0017	0.014	0.0129
Schistosoma mansoni	vav2	0.0022	0.0291	0.028
Trichomonas vaginalis	CMGC family protein kinase	0.0166	0.4532	1
Loa Loa (eye worm)	TK/FAK protein kinase	0.0306	0.8663	0.8663
Entamoeba histolytica	SH2-protein kinase domain containing protein	0.0019	0.0194	0.0384
Trichomonas vaginalis	CMGC family protein kinase	0.0166	0.4532	1
Loa Loa (eye worm)	CAMK/DAPK/DAPK protein kinase	0.0039	0.0786	0.0786
Brugia malayi	protein-tyrosine kinase	0.0019	0.0194	0.0194
Brugia malayi	Tyrosine-protein kinase abl-1	0.003	0.0533	0.0533
Schistosoma mansoni	proto-oncogene tyrosine-protein kinase src	0.003	0.0533	0.0522
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0271	0.0271
Toxoplasma gondii	CMGC kinase, CK2 family	0.0166	0.4532	1
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0037	0.0037
Echinococcus multilocularis	c src tyrosine kinase	0.003	0.0533	0.0522
Loa Loa (eye worm)	CAMK/MLCK protein kinase	0.0017	0.0142	0.0142
Echinococcus multilocularis	N chimaerin	0.0021	0.0244	0.0233
Loa Loa (eye worm)	hypothetical protein	0.002	0.0233	0.0233
Echinococcus multilocularis	aurora kinase A	0.0075	0.1845	0.1836
Schistosoma mansoni	serine/threonine protein kinase	0.0351	1	1
Trypanosoma brucei	kinetoplastid kinetochore protein 10	0.008	0.1986	0.4228
Brugia malayi	Phorbol esters/diacylglycerol binding domain	0.0018	0.017	0.017
Brugia malayi	Variant SH3 domain containing protein	0.0023	0.0321	0.0321
Schistosoma mansoni	serine/threonine protein kinase	0.0022	0.027	0.0259
Brugia malayi	Variant SH3 domain containing protein	0.0023	0.0321	0.0321
Schistosoma mansoni	serine/threonine protein kinase	0.0018	0.017	0.0159
Loa Loa (eye worm)	TK/KIN16 protein kinase	0.0228	0.6353	0.6353
Loa Loa (eye worm)	TK/FER protein kinase	0.0019	0.0194	0.0194
Echinococcus multilocularis	tyrosine protein kinase lyn tyrosine protein kinase blk	0.003	0.0533	0.0522
Schistosoma mansoni	tyrosine kinase	0.0015	0.0081	0.007
Loa Loa (eye worm)	CAMK protein kinase	0.0013	0.0011	0.0011
Brugia malayi	protein unc-22	0.0013	0.0011	0.0011
Brugia malayi	Protein kinase domain containing protein	0.0019	0.0194	0.0194
Loa Loa (eye worm)	AGC/PKC/ETA protein kinase	0.003	0.0532	0.0532
Brugia malayi	Variant SH3 domain containing protein	0.0013	0.0029	0.0029
Trichomonas vaginalis	AGC family protein kinase	0.0075	0.1845	0.3696
Schistosoma mansoni	serine/threonine protein kinase	0.0124	0.3285	0.3277
Trichomonas vaginalis	STE family protein kinase	0.0128	0.342	0.739
Echinococcus granulosus	tyrosine protein kinase Src42A	0.003	0.0533	0.0522
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.003	0.0533	0.0522
Brugia malayi	protein kinase C3,putative	0.0018	0.017	0.017
Echinococcus granulosus	insulin growth factor 1 receptor beta	0.0062	0.1467	0.1458
Trichomonas vaginalis	AGC family protein kinase	0.0023	0.0318	0.0111
Schistosoma mansoni	serine/threonine protein kinase	0.0075	0.1845	0.1836
Onchocerca volvulus		0.0019	0.0194	0.0183
Schistosoma mansoni	protein kinase	0.0166	0.4532	0.4526
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0065	0.0065
Schistosoma mansoni	tyrosine kinase	0.003	0.0533	0.0522
Schistosoma mansoni	tyrosine kinase	0.003	0.0533	0.0522
Loa Loa (eye worm)	hypothetical protein	0.003	0.0512	0.0512
Brugia malayi	Protein kinase domain containing protein	0.0019	0.0194	0.0194
Loa Loa (eye worm)	hypothetical protein	0.0013	0.0029	0.0029
Brugia malayi	Protein kinase domain containing protein	0.0062	0.1467	0.1467
Echinococcus granulosus	ankyrin repeat and death domain containing protein	0.002	0.0232	0.0221
Echinococcus granulosus	dual specificity testis-specific protein kinase	0.0016	0.0121	0.0109
Schistosoma mansoni	serine/threonine protein kinase	0.0128	0.342	0.3412
Schistosoma mansoni	tyrosine kinase	0.0302	0.8559	0.8558
Trichomonas vaginalis	CMGC family protein kinase	0.0166	0.4532	1
Loa Loa (eye worm)	immunoglobulin I-set domain-containing protein	0.002	0.0232	0.0232
Trypanosoma brucei	kinetoplastid kinetochore protein 19	0.008	0.1986	0.4228
Trypanosoma cruzi	kinetoplastid kinetochore protein 10, putative	0.008	0.1986	0.43
Schistosoma mansoni	protein kinase	0.0016	0.0121	0.0109
Brugia malayi	serine/threonine-protein kinase 6	0.0075	0.1845	0.1845
Schistosoma mansoni	serine/threonine protein kinase	0.0022	0.027	0.0259
Loa Loa (eye worm)	TK/FER protein kinase	0.0019	0.0194	0.0194
Trichomonas vaginalis	AGC family protein kinase	0.0075	0.1845	0.3696
Trichomonas vaginalis	CMGC family protein kinase	0.008	0.1986	0.4025
Trichomonas vaginalis	CMGC family protein kinase	0.0166	0.4532	1
Schistosoma mansoni	tyrosine kinase	0.0062	0.1467	0.1458
Brugia malayi	Furin-like cysteine rich region family protein	0.0181	0.4981	0.4981
Trypanosoma cruzi	kinetoplastid kinetochore protein 19, putative	0.008	0.1986	0.43
Loa Loa (eye worm)	AGC/RSK/RSK protein kinase	0.0022	0.027	0.027
Echinococcus granulosus	tyrosine protein kinase Srms	0.0019	0.0194	0.0183
Echinococcus multilocularis	tyrosine kinase	0.0019	0.0194	0.0183
Plasmodium falciparum	protein serine/threonine kinase-1	0.008	0.1986	0.4228
Plasmodium vivax	unspecified product	0.0166	0.4532	1
Toxoplasma gondii	cell-cycle-associated protein kinase CLK, putative	0.008	0.1986	0.4228
Loa Loa (eye worm)	TK/FER protein kinase	0.0019	0.0194	0.0194
Loa Loa (eye worm)	TK/FER protein kinase	0.0019	0.0194	0.0194
Loa Loa (eye worm)	variant SH3 domain-containing protein	0.0013	0.0029	0.0029
Schistosoma mansoni	dynamin-associated protein	0.0015	0.0065	0.0054
Trichomonas vaginalis	AGC family protein kinase	0.0023	0.0318	0.0111
Loa Loa (eye worm)	hypothetical protein	0.007	0.1712	0.1712
Loa Loa (eye worm)	hypothetical protein	0.0162	0.4413	0.4413
Loa Loa (eye worm)	TK/FER protein kinase	0.0019	0.0194	0.0194
Brugia malayi	Protein kinase domain containing protein	0.0019	0.0194	0.0194
Echinococcus granulosus	N chimaerin	0.0021	0.0244	0.0233
Toxoplasma gondii	aurora kinase	0.0075	0.1845	0.391
Echinococcus granulosus	tyrosine protein kinase Src64B	0.003	0.0533	0.0522
Giardia lamblia	Kinase, CMGC CLK	0.008	0.1986	0.0522
Loa Loa (eye worm)	SRC-1	0.003	0.0533	0.0533
Brugia malayi	Protein kinase domain containing protein	0.0022	0.027	0.027
Echinococcus granulosus	growth factor receptor bound protein 2	0.0026	0.0412	0.0402
Echinococcus granulosus	tyrosine kinase	0.0019	0.0194	0.0183
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.003	0.0533	0.0522
Echinococcus multilocularis	NCK adaptor protein	0.0026	0.0412	0.0402
Brugia malayi	Protein kinase domain containing protein	0.0019	0.0194	0.0194
Entamoeba histolytica	protein kinase, putative	0.0022	0.027	0.0553
Echinococcus granulosus	roundabout 2	0.0022	0.0271	0.026
Brugia malayi	hypothetical protein	0.0014	0.0037	0.0037
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0194	0.0194
Echinococcus granulosus	insulin receptor	0.0062	0.1467	0.1458
Echinococcus granulosus	tyrosine protein kinase Fps85D	0.0019	0.0194	0.0183
Loa Loa (eye worm)	RhoGAP domain-containing protein	0.0021	0.0244	0.0244
Echinococcus multilocularis	serine:threonine protein kinase 12 B	0.0075	0.1845	0.1836
Schistosoma mansoni	serine/threonine protein kinase	0.003	0.0532	0.0521
Loa Loa (eye worm)	CMGC/CLK protein kinase	0.008	0.1986	0.1986
Loa Loa (eye worm)	AGC/PKN protein kinase	0.0022	0.027	0.027
Echinococcus multilocularis	activin receptor type	0.0016	0.0121	0.0109
Schistosoma mansoni	netrin receptor unc5	0.0025	0.0363	0.0352
Entamoeba histolytica	protein kinase, putative	0.0023	0.0318	0.0658
Loa Loa (eye worm)	CAMK/PKD protein kinase	0.0018	0.017	0.017
Entamoeba histolytica	SH2-protein kinase domain containing protein	0.0021	0.0256	0.0521
Echinococcus multilocularis	roundabout 2	0.0022	0.0271	0.026
Echinococcus multilocularis	protein kinase c epsilon type	0.003	0.0532	0.0521
Entamoeba histolytica	serine/threonine- protein kinase 6 , putative	0.0075	0.1845	0.4045
Schistosoma mansoni	serine/threonine protein kinase	0.008	0.1986	0.1977
Schistosoma mansoni	serine/threonine protein kinase	0.003	0.0532	0.0521
Onchocerca volvulus		0.0202	0.5607	0.5602
Trichomonas vaginalis	AGC family protein kinase	0.0023	0.0318	0.0111
Echinococcus granulosus	ribosomal protein S6 kinase alpha 3	0.0022	0.027	0.0259
Echinococcus granulosus	tyrosine protein kinase Blk	0.0019	0.0194	0.0183
Echinococcus granulosus	tyrosine protein kinase ABL1	0.0019	0.0194	0.0183
Loa Loa (eye worm)	hypothetical protein	0.0171	0.4674	0.4674
Brugia malayi	Casein kinase II, alpha chain	0.0166	0.4532	0.4532
Schistosoma mansoni	ankyrin 23/unc44	0.002	0.0233	0.0222
Echinococcus granulosus	Ribosomal protein S6 kinase beta 2	0.0022	0.027	0.0259
Schistosoma mansoni	tyrosine kinase	0.0093	0.2379	0.2371
Loa Loa (eye worm)	hypothetical protein	0.003	0.0512	0.0512
Schistosoma mansoni	tyrosine kinase	0.003	0.0533	0.0522
Echinococcus granulosus	epidermal growth factor receptor	0.01	0.2591	0.2583
Plasmodium vivax	serine/threonine-specific protein kinase, putative	0.0128	0.342	0.586
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0037	0.0037
Onchocerca volvulus		0.0162	0.4413	0.4406
Echinococcus multilocularis	ankyrin repeat and death domain containing protein	0.002	0.0232	0.0221
Echinococcus granulosus	protein kinase c iota type	0.003	0.0532	0.0521
Echinococcus granulosus	proto oncogene tyrosine protein kinase LCK	0.003	0.0533	0.0522
Plasmodium vivax	casein kinase 2, alpha subunit, putative	0.0166	0.4532	1
Brugia malayi	RhoGAP domain containing protein	0.0021	0.0244	0.0244
Plasmodium falciparum	casein kinase 2, alpha subunit	0.0166	0.4532	1
Onchocerca volvulus		0.0019	0.0194	0.0183
Schistosoma mansoni	serine/threonine protein kinase	0.0022	0.027	0.0259
Schistosoma mansoni	chimerin-related rho-gtpase-activating protein	0.0021	0.0244	0.0233
Echinococcus granulosus	Protein kinase C brain isozyme	0.003	0.0532	0.0521
Brugia malayi	Uncoordinated protein 44	0.002	0.0233	0.0233
Brugia malayi	C1-like domain containing protein	0.0018	0.017	0.017
Echinococcus multilocularis	tyrosine protein kinase Src42A	0.0015	0.0074	0.0062
Echinococcus multilocularis	epidermal growth factor receptor	0.01	0.2591	0.2583
Trichomonas vaginalis	AGC family protein kinase	0.0023	0.0318	0.0111
Trypanosoma brucei	rac serine-threonine kinase, putative	0.0023	0.0318	0.0447
Schistosoma mansoni	Neurotrimin precursor (hNT)	0.0014	0.0037	0.0026
Echinococcus multilocularis	protein kinase c iota type	0.003	0.0532	0.0521
Brugia malayi	Sex muscle abnormal protein 5	0.0023	0.0321	0.0321
Leishmania major	protein kinase, putative	0.008	0.1986	0.43
Echinococcus multilocularis	tyrosine protein kinase Src64B	0.003	0.0533	0.0522
Echinococcus granulosus	tyrosine protein kinase Lyn	0.004	0.0807	0.0797
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0168	0.0168
Echinococcus multilocularis	dual specificity testis specific protein kinase	0.0016	0.0121	0.0109
Echinococcus granulosus	protein tyrosine kinase	0.0302	0.8559	0.8558
Echinococcus multilocularis	insulin growth factor 1 receptor beta	0.0062	0.1467	0.1458
Echinococcus multilocularis	serine:threonine protein kinase N2	0.0022	0.027	0.0259
Loa Loa (eye worm)	CAMK/PIM protein kinase	0.0351	1	1
Brugia malayi	p70 ribosomal S6 kinase beta	0.0022	0.027	0.027
Loa Loa (eye worm)	TK/FER protein kinase	0.0019	0.0194	0.0194
Schistosoma mansoni	vesicular amine transporter	0.0014	0.0037	0.0026
Schistosoma mansoni	protein kinase	0.0016	0.0121	0.0109
Onchocerca volvulus	Serine\/threonine protein kinase homolog	0.0351	1	1
Trichomonas vaginalis	CMGC family protein kinase	0.0166	0.4532	1
Echinococcus granulosus	tyrosine protein kinase Fyn	0.003	0.0533	0.0522
Brugia malayi	Protein kinase domain containing protein	0.0019	0.0194	0.0194
Brugia malayi	Variant SH3 domain containing protein	0.0015	0.0065	0.0065
Loa Loa (eye worm)	AGC/PKC/IOTA protein kinase	0.0018	0.017	0.017
Schistosoma mansoni	protein kinase	0.0075	0.1845	0.1836
Plasmodium falciparum	protein kinase, putative	0.0128	0.342	0.7478
Echinococcus granulosus	tyrosine kinase\|tyrosine protein kinase Fyn	0.0019	0.0194	0.0183
Loa Loa (eye worm)	hypothetical protein	0.0183	0.5048	0.5048
Trichomonas vaginalis	AGC family protein kinase	0.0075	0.1845	0.3696
Echinococcus multilocularis	serine threonine protein kinase	0.0128	0.342	0.3412
Echinococcus granulosus	tyrosine protein kinase Src42A	0.0015	0.0074	0.0062
Brugia malayi	Fibronectin type III domain containing protein	0.0014	0.0037	0.0037
Toxoplasma gondii	AGC kinase	0.0022	0.027	0.034
Schistosoma mansoni	tyrosine kinase	0.0178	0.4878	0.4872
Schistosoma mansoni	tyrosine kinase	0.003	0.0533	0.0522
Echinococcus granulosus	3'partial\|tyrosine protein kinase Fgr	0.003	0.0533	0.0522
Schistosoma mansoni	nck2/grb4	0.0023	0.0321	0.031
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0321	0.0321
Entamoeba histolytica	serine/threonine protein kinase 6, putative	0.0075	0.1845	0.4045
Loa Loa (eye worm)	AUR protein kinase	0.0075	0.1845	0.1845
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0019	0.0194	0.0183
Schistosoma mansoni	tyrosine kinase	0.0181	0.4981	0.4975
Schistosoma mansoni	tyrosine kinase	0.01	0.2591	0.2583
Schistosoma mansoni	development and differentiation-enhancing factor ddef	0.0013	0.0021	0.0009
Onchocerca volvulus		0.0019	0.0194	0.0183
Echinococcus granulosus	activin receptor type	0.0016	0.0121	0.0109
Entamoeba histolytica	protein kinase domain containing protein	0.0016	0.0121	0.0221
Echinococcus multilocularis	raf serine:threonine protein kinase	0.0016	0.0108	0.0097
Onchocerca volvulus		0.0021	0.0247	0.0236
Schistosoma mansoni	serine/threonine protein kinase	0.003	0.0532	0.0521
Echinococcus multilocularis	proto oncogene tyrosine protein kinase LCK	0.003	0.0533	0.0522
Loa Loa (eye worm)	TK protein kinase	0.0019	0.0194	0.0194
Onchocerca volvulus		0.0019	0.0194	0.0183
Schistosoma mansoni	protein kinase	0.0016	0.0121	0.0109
Entamoeba histolytica	protein kinase domain containing protein	0.0166	0.4532	1

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

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Bibliographic References

No literature references available for this target.

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Detailed information for compound 879189